9AXM

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
ARAF (Serine/threonine-protein kinase A-Raf)
Group: TKL STE
Uniprot: MP2K1_HUMAN ARAF_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361 310 - 569
Resolution: 2.42

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out A1AHE ANP Type1 Type1 38 - 382 0
C STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-none out-out A1AHE Type1 43 - 376 0
B TKL ARAF ARAF_HUMAN Serine/threonine-protein kinase A-Raf Homo sapiens Inactive DFGin BLBplus out-out none-in ANP Type1 302 - 574 17
D TKL ARAF ARAF_HUMAN Serine/threonine-protein kinase A-Raf Homo sapiens None DFGin BLAminus in-in in-none No_ligand No_ligand 300 - 574 14
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain D
       306        316        326        336 
gdsGDDWEVP PSEVQLLKRI GTgsfGTVFR GRWHGDVAVK 
       346        356        366        376 
VLkvSQPTAE QAQAFKNEMQ VLRKTRHVNI LLFMGFMTRP 
       386        396        406        416 
GFAIITQWCE GSSLYHHLHV ADTRFDMVQL IDVARQTAQG 
       426        436        446        456 
MDYLHAKNII HRDLKSNNIF LHEGLTVKIG DFGLATVKtr 
       466        476        486        496 
wsgaqpleqp sgSVLWMAAE VIRMQDPNPY SFQSDVYAYG 
       506        516        526        536 
VVLYELMTGS LPYSHIGCRD QIIFMVGRGY LSPDLSKISS 
       546        556        566        576 
NCPKAMRRLL SDCLKFQREE RPLFPQILAT IELLQRSLpk


Lower-case residues are disordered in structure.
Mutations: Y301D,Y302D
Phosphorylation: None