Ligand: VGH (Crizotinib)

Total number of chains: 9
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 8 88.9% 5AAAA
DFGin BLBplus 1 11.1% 2WGJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR ALK ALK_HUMAN 4ANSA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2485 15.1618 ABAminus -128.23, -41.44 -98.11, 120.9 -117.53, 30.59 287.81, 85.26 -66.49, -38.26 in-out in 8.265 Saltbr-out 4.8918 HRD-in -72.85, -44.3 78.64, -9.03 out-out-out SNCooo out-out ActLoopNT-out 6.908 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.15, -7.92 APE9-dihe-in -66.26, 134.84 APE8-dihe-in -77.14, 60.8 APE8-rot-na 30.33 APE67-dihe-in -70.27, -10.51 -58.92, -29.59 APE12-dist-na 14.6611 APE11-dist-na 14.8834 APE10-dist-na 9.857 APE9-dist-out 8.0387 L1196M,G1269A None None XRAY 1.85 0.201 0.231 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4ans TYR_ALK_HUMAN TYR 5.2e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 2YFXA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2206 14.8808 ABAminus -122.22, -28.6 -114.9, 132.72 -127.11, 33.52 293.03, 85.04 -65.89, -37.73 in-out in 7.9144 Saltbr-out 4.7498 HRD-in -73.95, -43.63 78.32, -9.23 out-out-out SNCooo out-out ActLoopNT-out 6.9557 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.12, -9.34 APE9-dihe-in -61.51, 137.47 APE8-dihe-in -77.72, 57.54 APE8-rot-na 29.78 APE67-dihe-in -70.24, -8.94 -56.4, -32.44 APE12-dist-na 14.505 APE11-dist-na 14.9332 APE10-dist-na 9.9197 APE9-dist-out 8.0505 L1196M None None XRAY 1.7 0.208 0.234 A 327.0 293.0 16 30 24 6 [[1116, 1385]] 1.0 2yfx TYR_ALK_HUMAN TYR 5.1e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4ANQA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2087 14.9738 ABAminus -128.3, -36.39 -101.79, 127.42 -123.56, 31.99 288.31, 85.14 -69.12, -35.87 in-out in 8.2697 Saltbr-out 4.7889 HRD-in -73.02, -46.15 80.91, -7.4 out-out-out SNCooo out-out ActLoopNT-out 6.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.41, -8.07 APE9-dihe-in -67.75, 134.94 APE8-dihe-in -74.89, 59.28 APE8-rot-na 29.64 APE67-dihe-in -70.46, -10.96 -58.56, -29.68 APE12-dist-na 14.7237 APE11-dist-na 14.9551 APE10-dist-na 9.9221 APE9-dist-out 8.0186 G1269A None None XRAY 1.76 0.201 0.217 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4anq TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AAAA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2088 14.916 ABAminus -119.08, -27.29 -116.14, 136.82 -130.64, 32.52 289.46, 85.69 -67.72, -37.15 in-out in 7.9686 Saltbr-out 4.6697 HRD-in -74.4, -45.03 79.43, -9.27 out-out-out SNCooo out-out ActLoopNT-out 6.8981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.98, -3.96 APE9-dihe-in -73.12, 136.6 APE8-dihe-in -77.4, 61.62 APE8-rot-na 28.9 APE67-dihe-in -71.26, -10.51 -60.21, -28.6 APE12-dist-na 14.5554 APE11-dist-na 14.8493 APE10-dist-na 9.8001 APE9-dist-out 8.0299 L1198F None None XRAY 1.73 0.201 0.206 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 5aaa TYR_ALK_HUMAN TYR 4.4e-91 310.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AABA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 5.962 14.9414 ABAminus -122.06, -28.4 -115.22, 132.25 -127.31, 26.85 289.37, 81.1 -65.12, -33.9 in-out in 8.0829 Saltbr-out 4.2699 HRD-in -73.35, -48.11 83.65, -8.17 out-out-out SNCooo out-out ActLoopNT-out 6.9633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, -2.64 APE9-dihe-in -78.59, 133.38 APE8-dihe-in -74.05, 62.22 APE8-rot-na 30.08 APE67-dihe-in -71.71, -12.93 -64.03, -23.79 APE12-dist-na 15.1004 APE11-dist-na 15.2049 APE10-dist-na 10.0874 APE9-dist-out 8.0863 C1156Y,L1198F None None XRAY 2.2 0.211 0.246 A 327.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 5aab TYR_ALK_HUMAN TYR 5.9e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 2XP2A Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.01 14.8527 ABAminus -116.89, -30.31 -113.6, 135.35 -129.42, 33.32 290.86, 85.52 -68.93, -36.66 in-out in 8.312 Saltbr-out 4.8435 HRD-in -70.6, -46.14 82.26, -7.39 out-out-out SNCooo out-out ActLoopNT-out 6.7853 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -14.78 APE9-dihe-in -71.8, 131.97 APE8-dihe-in -75.49, 62.54 APE8-rot-na 30.87 APE67-dihe-in -72.66, -13.49 -62.38, -23.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.1483 APE9-dist-out 8.2573 None None None XRAY 1.9 0.207 0.252 A 327.0 289.0 20 30 21 9 [[1116, 1385]] 1.0 2xp2 TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AACA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.0491 14.9478 ABAminus -115.19, -31.77 -111.83, 134.22 -128.43, 30.25 290.07, 81.16 -65.53, -32.88 in-out in 8.2704 Saltbr-out 4.6082 HRD-in -73.86, -46.4 82.42, -9.17 out-out-out SNCooo out-out ActLoopNT-out 6.9248 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.47, -8.93 APE9-dihe-in -64.75, 135.46 APE8-dihe-in -76.69, 59.35 APE8-rot-na 30.37 APE67-dihe-in -71.48, -11.11 -59.44, -28.8 APE12-dist-na 14.7445 APE11-dist-na 15.3235 APE10-dist-na 10.293 APE9-dist-out 8.1919 C1156Y None None XRAY 1.7 0.208 0.232 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5aac TYR_ALK_HUMAN TYR 1.9e-90 308.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR MET MET_HUMAN 2WGJA P08581 1052 1345 1390.0 VGH:2346 Type1 Inactive DFGin 5.4186 14.21 BLBplus -135.65, -156.26 47.26, 45.25 -135.61, 161.65 71.89, 90.85 65.05, -128.27 out-out out 14.4314 Saltbr-out 12.3445 HRD-in -73.92, -55.59 85.56, -13.18 out-out-in SNCooi out-in ActLoopNT-out 10.8902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.61, 121.54 APE9-dihe-in -139.09, 151.01 APE8-dihe-in -79.04, 70.35 APE8-rot-na 28.98 APE67-dihe-in -76.22, -0.44 -56.63, -35.75 APE12-dist-na 22.7041 APE11-dist-na 17.972 APE10-dist-na 17.3403 APE9-dist-in 7.1491 None None None XRAY 2.0 0.215 0.232 A 306.0 290.0 4 32 32 0 [[1078, 1339]] 1.0 2wgj TYR_MET_HUMAN TYR 6.7e-92 313.6 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR ROS1 ROS1_HUMAN 3ZBFA P08922 1934 2230 2347.0 VGH:3000 Type1 Inactive DFGin 6.5532 14.5602 ABAminus -129.17, -37.91 -114.96, 123.49 -118.51, 31.51 297.44, 69.18 -62.83, -16.28 in-in in 8.5059 Saltbr-in 3.4994 HRD-in -86.85, -45.31 73.51, 7.34 in-in-out SNCiio in-out ActLoopNT-in 2.9375 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -30.1 APE8-dihe-in -94.83, 74.5 APE8-rot-na 33.93 APE67-dihe-in -65.41, -17.17 -63.88, -31.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.0999 None None None XRAY 2.2 0.236 0.282 A 322.0 282.0 15 30 18 12 [[1945, 2217]] 1.0 3zbf TYR_ROS1_HUMAN TYR 5.4e-95 323.5 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS

Ligand: VGH (Crizotinib)

Total number of chains: 9
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 8 88.9% 5AAAA
DFGin BLBplus 1 11.1% 2WGJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR ALK ALK_HUMAN 4ANSA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2485 15.1618 ABAminus -128.23, -41.44 -98.11, 120.9 -117.53, 30.59 287.81, 85.26 -66.49, -38.26 in-out in 8.265 Saltbr-out 4.8918 HRD-in -72.85, -44.3 78.64, -9.03 out-out-out SNCooo out-out ActLoopNT-out 6.908 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.15, -7.92 APE9-dihe-in -66.26, 134.84 APE8-dihe-in -77.14, 60.8 APE8-rot-na 30.33 APE67-dihe-in -70.27, -10.51 -58.92, -29.59 APE12-dist-na 14.6611 APE11-dist-na 14.8834 APE10-dist-na 9.857 APE9-dist-out 8.0387 L1196M,G1269A None None XRAY 1.85 0.201 0.231 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4ans Homo sapiens TYR_ALK_HUMAN TYR 5.2e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 2YFXA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2206 14.8808 ABAminus -122.22, -28.6 -114.9, 132.72 -127.11, 33.52 293.03, 85.04 -65.89, -37.73 in-out in 7.9144 Saltbr-out 4.7498 HRD-in -73.95, -43.63 78.32, -9.23 out-out-out SNCooo out-out ActLoopNT-out 6.9557 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.12, -9.34 APE9-dihe-in -61.51, 137.47 APE8-dihe-in -77.72, 57.54 APE8-rot-na 29.78 APE67-dihe-in -70.24, -8.94 -56.4, -32.44 APE12-dist-na 14.505 APE11-dist-na 14.9332 APE10-dist-na 9.9197 APE9-dist-out 8.0505 L1196M None None XRAY 1.7 0.208 0.234 A 327.0 293.0 16 30 24 6 [[1116, 1385]] 1.0 2yfx Homo sapiens TYR_ALK_HUMAN TYR 5.1e-91 310.5 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4ANQA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.2087 14.9738 ABAminus -128.3, -36.39 -101.79, 127.42 -123.56, 31.99 288.31, 85.14 -69.12, -35.87 in-out in 8.2697 Saltbr-out 4.7889 HRD-in -73.02, -46.15 80.91, -7.4 out-out-out SNCooo out-out ActLoopNT-out 6.947 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -98.41, -8.07 APE9-dihe-in -67.75, 134.94 APE8-dihe-in -74.89, 59.28 APE8-rot-na 29.64 APE67-dihe-in -70.46, -10.96 -58.56, -29.68 APE12-dist-na 14.7237 APE11-dist-na 14.9551 APE10-dist-na 9.9221 APE9-dist-out 8.0186 G1269A None None XRAY 1.76 0.201 0.217 A 342.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 4anq Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AAAA Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.2088 14.916 ABAminus -119.08, -27.29 -116.14, 136.82 -130.64, 32.52 289.46, 85.69 -67.72, -37.15 in-out in 7.9686 Saltbr-out 4.6697 HRD-in -74.4, -45.03 79.43, -9.27 out-out-out SNCooo out-out ActLoopNT-out 6.8981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -99.98, -3.96 APE9-dihe-in -73.12, 136.6 APE8-dihe-in -77.4, 61.62 APE8-rot-na 28.9 APE67-dihe-in -71.26, -10.51 -60.21, -28.6 APE12-dist-na 14.5554 APE11-dist-na 14.8493 APE10-dist-na 9.8001 APE9-dist-out 8.0299 L1198F None None XRAY 1.73 0.201 0.206 A 327.0 295.0 14 30 24 6 [[1116, 1385]] 1.0 5aaa Homo sapiens TYR_ALK_HUMAN TYR 4.4e-91 310.7 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AABA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 5.962 14.9414 ABAminus -122.06, -28.4 -115.22, 132.25 -127.31, 26.85 289.37, 81.1 -65.12, -33.9 in-out in 8.0829 Saltbr-out 4.2699 HRD-in -73.35, -48.11 83.65, -8.17 out-out-out SNCooo out-out ActLoopNT-out 6.9633 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.88, -2.64 APE9-dihe-in -78.59, 133.38 APE8-dihe-in -74.05, 62.22 APE8-rot-na 30.08 APE67-dihe-in -71.71, -12.93 -64.03, -23.79 APE12-dist-na 15.1004 APE11-dist-na 15.2049 APE10-dist-na 10.0874 APE9-dist-out 8.0863 C1156Y,L1198F None None XRAY 2.2 0.211 0.246 A 327.0 294.0 16 30 24 6 [[1116, 1385]] 1.0 5aab Homo sapiens TYR_ALK_HUMAN TYR 5.9e-91 310.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 2XP2A Q9UM73 1093 1401 1620.0 VGH:9000 Type1 Inactive DFGin 6.01 14.8527 ABAminus -116.89, -30.31 -113.6, 135.35 -129.42, 33.32 290.86, 85.52 -68.93, -36.66 in-out in 8.312 Saltbr-out 4.8435 HRD-in -70.6, -46.14 82.26, -7.39 out-out-out SNCooo out-out ActLoopNT-out 6.7853 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -14.78 APE9-dihe-in -71.8, 131.97 APE8-dihe-in -75.49, 62.54 APE8-rot-na 30.87 APE67-dihe-in -72.66, -13.49 -62.38, -23.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.1483 APE9-dist-out 8.2573 None None None XRAY 1.9 0.207 0.252 A 327.0 289.0 20 30 21 9 [[1116, 1385]] 1.0 2xp2 Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 5AACA Q9UM73 1093 1402 1620.0 VGH:9000 Type1 Inactive DFGin 6.0491 14.9478 ABAminus -115.19, -31.77 -111.83, 134.22 -128.43, 30.25 290.07, 81.16 -65.53, -32.88 in-out in 8.2704 Saltbr-out 4.6082 HRD-in -73.86, -46.4 82.42, -9.17 out-out-out SNCooo out-out ActLoopNT-out 6.9248 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -100.47, -8.93 APE9-dihe-in -64.75, 135.46 APE8-dihe-in -76.69, 59.35 APE8-rot-na 30.37 APE67-dihe-in -71.48, -11.11 -59.44, -28.8 APE12-dist-na 14.7445 APE11-dist-na 15.3235 APE10-dist-na 10.293 APE9-dist-out 8.1919 C1156Y None None XRAY 1.7 0.208 0.232 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 5aac Homo sapiens TYR_ALK_HUMAN TYR 1.9e-90 308.6 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR MET MET_HUMAN 2WGJA P08581 1052 1345 1390.0 VGH:2346 Type1 Inactive DFGin 5.4186 14.21 BLBplus -135.65, -156.26 47.26, 45.25 -135.61, 161.65 71.89, 90.85 65.05, -128.27 out-out out 14.4314 Saltbr-out 12.3445 HRD-in -73.92, -55.59 85.56, -13.18 out-out-in SNCooi out-in ActLoopNT-out 10.8902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -55.61, 121.54 APE9-dihe-in -139.09, 151.01 APE8-dihe-in -79.04, 70.35 APE8-rot-na 28.98 APE67-dihe-in -76.22, -0.44 -56.63, -35.75 APE12-dist-na 22.7041 APE11-dist-na 17.972 APE10-dist-na 17.3403 APE9-dist-in 7.1491 None None None XRAY 2.0 0.215 0.232 A 306.0 290.0 4 32 32 0 [[1078, 1339]] 1.0 2wgj Homo sapiens TYR_MET_HUMAN TYR 6.7e-92 313.6 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR ROS1 ROS1_HUMAN 3ZBFA P08922 1934 2230 2347.0 VGH:3000 Type1 Inactive DFGin 6.5532 14.5602 ABAminus -129.17, -37.91 -114.96, 123.49 -118.51, 31.51 297.44, 69.18 -62.83, -16.28 in-in in 8.5059 Saltbr-in 3.4994 HRD-in -86.85, -45.31 73.51, 7.34 in-in-out SNCiio in-out ActLoopNT-in 2.9375 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -30.1 APE8-dihe-in -94.83, 74.5 APE8-rot-na 33.93 APE67-dihe-in -65.41, -17.17 -63.88, -31.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.0999 None None None XRAY 2.2 0.236 0.282 A 322.0 282.0 15 30 18 12 [[1945, 2217]] 1.0 3zbf Homo sapiens TYR_ROS1_HUMAN TYR 5.4e-95 323.5 3.0 260.0 258.0 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079.0 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS

Ligand: VGH (Crizotinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name