Ligand: BI4

Total number of chains: 5
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 100.0% 3OTUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PDPK1 PDPK1_HUMAN 3ORZA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORZB 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORZC 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3ORZD 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3OTUA 2.101 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J30, BI4 Allosteric, Type1.5_Front 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1

Ligand: BI4

Total number of chains: 7
Active chains: 2
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 85.7% 1SZMA
DFGin ABAminus 1 14.3% 1SZMB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_BOVIN 1SZMB 2.5 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii BI4 Type1 15 - 351 0 SEP140,TPO198,SEP339 V124A,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1SZMA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI4 Type1 16 - 351 0 SEP140,TPO198,SEP339 V124A,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PDPK1 PDPK1_HUMAN 3ORZA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORZB 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORZC 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3ORZD 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3OTUA 2.101 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J30, BI4 Allosteric, Type1.5_Front 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens

Ligand: BI4

Total number of chains: 2
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 1SZMB
DFGin BLAminus 1 50.0% 1SZMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_BOVIN 1SZMB 2.5 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii BI4 Type1 15 - 351 0 SEP140,TPO198,SEP339 V124A,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 1SZMA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BI4 Type1 16 - 351 0 SEP140,TPO198,SEP339 V124A,L174M,Q182K cAMP-dependent protein kinase catalytic subunit alpha Bos taurus