Ligand: 88Z (Foretinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 50.0% 6SDCA
DFGout None 3 50.0% 5IA4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE STK10 STK10_HUMAN 6I2YA 2.56 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YB 2.56 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
TYR EPHA2 EPHA2_HUMAN 5IA4A 1.797 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 605 - 877 0 None None Ephrin type-A receptor 2
TYR MET MET_HUMAN 6SDCA 1.67 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3LQ8A 2.02 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1053 - 1345 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 6SD9A 2.35 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1062 - 1345 0 None None Hepatocyte growth factor receptor

Ligand: 88Z (Foretinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 50.0% 6SDCA
DFGout None 3 50.0% 5IA4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE STK10 STK10_HUMAN 6I2YA 2.56 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6I2YB 2.56 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 5IA4A 1.797 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 605 - 877 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR MET MET_HUMAN 6SDCA 1.67 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3LQ8A 2.02 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1053 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 6SD9A 2.35 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1062 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens

Ligand: 88Z (Foretinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism