Ligand: 88Z (Foretinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 50.0% 6SDCA
DFGout None 3 50.0% 5IA4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE STK10 STK10_HUMAN 6I2YA O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.2556 8.5742 None -142.6, 167.0 -107.59, -54.88 62.87, -46.4 275.81, 122.12 -90.27, -135.26 out-out out 10.9458 Saltbr-out 9.6562 HRD-in -100.04, -54.51 71.49, 1.4 out-in-out SNCoio in-out ActLoopNT-in 3.4539 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -142.05 APE9-dihe-na -118.43, -179.23 APE8-dihe-in -77.25, 139.36 APE8-rot-in 315.91 APE67-dihe-in -58.76, -37.44 -65.9, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.8257 APE9-dist-out 27.3635 None None None XRAY 2.56 0.264 0.283 A 302.0 279.0 15 28 18 10 [[36, 294]] 1.0 6i2y STE_STK10_HUMAN STE 4.6e-94 320.5 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YB O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.2563 8.8941 None -141.77, 169.33 -104.17, -54.09 61.03, 36.32 275.49, 122.46 -178.77, -139.27 out-none out 10.5233 Saltbr-none 999.0 HRD-in -100.14, -55.33 72.94, 1.28 none-out-out SNCnoo out-out ActLoopNT-out 3.9964 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -121.96, -178.86 APE8-dihe-in -77.3, 140.17 APE8-rot-none 999.0 APE67-dihe-in -63.08, -39.73 -66.89, -45.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.6261 APE9-dist-out 26.5449 None None None XRAY 2.56 0.264 0.283 B 302.0 277.0 17 28 18 10 [[36, 294]] 1.0 6i2y STE_STK10_HUMAN STE 4.6e-94 320.5 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
TYR EPHA2 EPHA2_HUMAN 5IA4A P29317 605 877 976.0 88Z:1001 Type2 Inactive DFGout 13.8114 6.3046 None -141.42, 176.32 -148.43, 94.59 -58.84, -30.4 187.59, 75.41 105.04, 22.91 in-out in 9.5712 Saltbr-out 4.6872 HRD-in -75.95, -50.56 75.81, -10.01 out-out-in SNCooi out-in ActLoopNT-out 12.322 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.68, 164.18 APE9-dihe-in -115.64, 144.62 APE8-dihe-in -83.58, 93.81 APE8-rot-na 29.41 APE67-dihe-in -65.12, -16.72 -54.94, -46.13 APE12-dist-na 12.5477 APE11-dist-na 8.9809 APE10-dist-na 8.2819 APE9-dist-in 5.9107 None None None XRAY 1.797 0.19 0.226 A 306.0 269.0 4 31 31 0 [[613, 873]] 1.0 5ia4 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR MET MET_HUMAN 6SDCA P08581 1052 1346 1390.0 88Z:1401 Type2 Inactive DFGout 14.755 9.9915 BBAminus -145.61, -169.98 -156.56, 116.19 -59.96, -26.46 279.97, 77.13 50.32, -121.48 in-in in 8.796 Saltbr-in 2.8606 HRD-in -66.32, -54.96 80.1, -13.51 in-out-in SNCioi out-in ActLoopNT-out 16.3858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.94, 108.39 APE9-dihe-in -108.81, 143.16 APE8-dihe-in -83.72, 68.12 APE8-rot-na 31.17 APE67-dihe-in -78.0, -5.37 -48.86, -37.15 APE12-dist-na 999.0 APE11-dist-na 13.258 APE10-dist-na 11.1021 APE9-dist-in 7.1659 D1228V None None XRAY 1.67 0.203 0.242 A 309.0 286.0 9 32 27 5 [[1078, 1339]] 1.0 6sdc TYR_MET_HUMAN TYR 1.5e-91 312.8 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3LQ8A P08581 1053 1345 1390.0 88Z:1 Type2 Inactive DFGout 14.8607 9.9894 BBAminus -150.09, -172.74 -147.86, 117.02 -56.28, -26.81 274.5, 87.89 59.54, -126.97 in-in in 8.6474 Saltbr-in 2.6997 HRD-in -70.16, -54.71 79.85, -12.74 in-out-in SNCioi out-in ActLoopNT-out 16.4462 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.38, 117.69 APE9-dihe-in -124.2, 124.76 APE8-dihe-in -78.42, 71.53 APE8-rot-na 27.34 APE67-dihe-in -76.25, -4.88 -56.16, -37.64 APE12-dist-na 999.0 APE11-dist-na 14.0073 APE10-dist-na 9.8907 APE9-dist-in 7.1292 None None None XRAY 2.02 0.194 0.252 A 302.0 278.0 15 32 24 8 [[1078, 1339]] 1.0 3lq8 TYR_MET_HUMAN TYR 6.4e-92 313.6 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 6SD9A P08581 1062 1345 1390.0 88Z:1402 Type2 Inactive DFGout 14.8753 10.0886 BBAminus -142.16, -169.29 -149.74, 121.34 -65.96, -2.71 275.09, 79.25 44.01, -118.14 in-in in 8.8355 Saltbr-in 3.0626 HRD-in -63.65, -57.37 87.84, -32.21 in-out-in SNCioi out-in ActLoopNT-out 15.8096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.67, 97.49 APE9-dihe-in -110.0, 137.15 APE8-dihe-in -89.8, 72.46 APE8-rot-na 28.25 APE67-dihe-in -72.7, -14.18 -53.41, -37.28 APE12-dist-na 14.5575 APE11-dist-na 14.7007 APE10-dist-na 9.852 APE9-dist-in 7.6068 None None None XRAY 2.35 0.212 0.27 A 309.0 265.0 19 32 23 9 [[1078, 1339]] 1.0 6sd9 TYR_MET_HUMAN TYR 6.9e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 88Z (Foretinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 50.0% 6SDCA
DFGout None 3 50.0% 5IA4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE STK10 STK10_HUMAN 6I2YA O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.2556 8.5742 None -142.6, 167.0 -107.59, -54.88 62.87, -46.4 275.81, 122.12 -90.27, -135.26 out-out out 10.9458 Saltbr-out 9.6562 HRD-in -100.04, -54.51 71.49, 1.4 out-in-out SNCoio in-out ActLoopNT-in 3.4539 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -142.05 APE9-dihe-na -118.43, -179.23 APE8-dihe-in -77.25, 139.36 APE8-rot-in 315.91 APE67-dihe-in -58.76, -37.44 -65.9, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.8257 APE9-dist-out 27.3635 None None None XRAY 2.56 0.264 0.283 A 302.0 279.0 15 28 18 10 [[36, 294]] 1.0 6i2y Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YB O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.2563 8.8941 None -141.77, 169.33 -104.17, -54.09 61.03, 36.32 275.49, 122.46 -178.77, -139.27 out-none out 10.5233 Saltbr-none 999.0 HRD-in -100.14, -55.33 72.94, 1.28 none-out-out SNCnoo out-out ActLoopNT-out 3.9964 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -121.96, -178.86 APE8-dihe-in -77.3, 140.17 APE8-rot-none 999.0 APE67-dihe-in -63.08, -39.73 -66.89, -45.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.6261 APE9-dist-out 26.5449 None None None XRAY 2.56 0.264 0.283 B 302.0 277.0 17 28 18 10 [[36, 294]] 1.0 6i2y Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1.0 257.0 257.0 174 175 176 178 180 65 81 85 154 156 155 157.0 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
TYR EPHA2 EPHA2_HUMAN 5IA4A P29317 605 877 976.0 88Z:1001 Type2 Inactive DFGout 13.8114 6.3046 None -141.42, 176.32 -148.43, 94.59 -58.84, -30.4 187.59, 75.41 105.04, 22.91 in-out in 9.5712 Saltbr-out 4.6872 HRD-in -75.95, -50.56 75.81, -10.01 out-out-in SNCooi out-in ActLoopNT-out 12.322 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.68, 164.18 APE9-dihe-in -115.64, 144.62 APE8-dihe-in -83.58, 93.81 APE8-rot-na 29.41 APE67-dihe-in -65.12, -16.72 -54.94, -46.13 APE12-dist-na 12.5477 APE11-dist-na 8.9809 APE10-dist-na 8.2819 APE9-dist-in 5.9107 None None None XRAY 1.797 0.19 0.226 A 306.0 269.0 4 31 31 0 [[613, 873]] 1.0 5ia4 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR MET MET_HUMAN 6SDCA P08581 1052 1346 1390.0 88Z:1401 Type2 Inactive DFGout 14.755 9.9915 BBAminus -145.61, -169.98 -156.56, 116.19 -59.96, -26.46 279.97, 77.13 50.32, -121.48 in-in in 8.796 Saltbr-in 2.8606 HRD-in -66.32, -54.96 80.1, -13.51 in-out-in SNCioi out-in ActLoopNT-out 16.3858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.94, 108.39 APE9-dihe-in -108.81, 143.16 APE8-dihe-in -83.72, 68.12 APE8-rot-na 31.17 APE67-dihe-in -78.0, -5.37 -48.86, -37.15 APE12-dist-na 999.0 APE11-dist-na 13.258 APE10-dist-na 11.1021 APE9-dist-in 7.1659 D1228V None None XRAY 1.67 0.203 0.242 A 309.0 286.0 9 32 27 5 [[1078, 1339]] 1.0 6sdc Homo sapiens TYR_MET_HUMAN TYR 1.5e-91 312.8 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3LQ8A P08581 1053 1345 1390.0 88Z:1 Type2 Inactive DFGout 14.8607 9.9894 BBAminus -150.09, -172.74 -147.86, 117.02 -56.28, -26.81 274.5, 87.89 59.54, -126.97 in-in in 8.6474 Saltbr-in 2.6997 HRD-in -70.16, -54.71 79.85, -12.74 in-out-in SNCioi out-in ActLoopNT-out 16.4462 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.38, 117.69 APE9-dihe-in -124.2, 124.76 APE8-dihe-in -78.42, 71.53 APE8-rot-na 27.34 APE67-dihe-in -76.25, -4.88 -56.16, -37.64 APE12-dist-na 999.0 APE11-dist-na 14.0073 APE10-dist-na 9.8907 APE9-dist-in 7.1292 None None None XRAY 2.02 0.194 0.252 A 302.0 278.0 15 32 24 8 [[1078, 1339]] 1.0 3lq8 Homo sapiens TYR_MET_HUMAN TYR 6.4e-92 313.6 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 6SD9A P08581 1062 1345 1390.0 88Z:1402 Type2 Inactive DFGout 14.8753 10.0886 BBAminus -142.16, -169.29 -149.74, 121.34 -65.96, -2.71 275.09, 79.25 44.01, -118.14 in-in in 8.8355 Saltbr-in 3.0626 HRD-in -63.65, -57.37 87.84, -32.21 in-out-in SNCioi out-in ActLoopNT-out 15.8096 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.67, 97.49 APE9-dihe-in -110.0, 137.15 APE8-dihe-in -89.8, 72.46 APE8-rot-na 28.25 APE67-dihe-in -72.7, -14.18 -53.41, -37.28 APE12-dist-na 14.5575 APE11-dist-na 14.7007 APE10-dist-na 9.852 APE9-dist-in 7.6068 None None None XRAY 2.35 0.212 0.27 A 309.0 265.0 19 32 23 9 [[1078, 1339]] 1.0 6sd9 Homo sapiens TYR_MET_HUMAN TYR 6.9e-92 313.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 88Z (Foretinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name