Ligand: 88Z (Foretinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 50.0% 6SDCA
DFGout None 3 50.0% 5IA4A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE STK10 STK10_HUMAN 6I2YA O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.574 None -142.6, 167.0 -107.59, -54.88 62.87, -46.4 275.81, 122.12 -90.27, -135.26 out-out out 10.946 Saltbr-out 9.656 HRD-in -100.04, -54.51 71.49, 1.4 out-in-out SNCoio in-out ActLoopNT-in 3.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -142.05 APE9-dihe-na -118.43, -179.23 APE8-dihe-in -77.25, 139.36 APE8-rot-in 315.91 APE67-dihe-in -58.76, -37.44 -65.9, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.826 APE9-dist-out 27.363 None None None XRAY 2.56 0.264 0.283 A 302 279 15 0 0 10 [[36, 294]] 1.0 6i2y STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YB O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.894 None -141.77, 169.33 -104.17, -54.09 61.03, 36.32 275.49, 122.46 -178.77, -139.27 out-none out 10.523 Saltbr-none 999.0 HRD-in -100.14, -55.33 72.94, 1.28 none-out-out SNCnoo out-out ActLoopNT-out 3.996 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -121.96, -178.86 APE8-dihe-in -77.3, 140.17 APE8-rot-none 999.0 APE67-dihe-in -63.08, -39.73 -66.89, -45.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.626 APE9-dist-out 26.545 None None None XRAY 2.56 0.264 0.283 B 302 277 17 0 0 10 [[36, 294]] 1.0 6i2y STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
TYR EPHA2 EPHA2_HUMAN 5IA4A P29317 605 877 976.0 88Z:1001 Type2 Inactive DFGout 13.811 6.305 None -141.42, 176.32 -148.43, 94.59 -58.84, -30.4 187.59, 75.41 105.04, 22.91 in-out in 9.571 Saltbr-out 4.687 HRD-in -75.95, -50.56 75.81, -10.01 out-out-in SNCooi out-in ActLoopNT-out 12.322 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.68, 164.18 APE9-dihe-in -115.64, 144.62 APE8-dihe-in -83.58, 93.81 APE8-rot-na 29.41 APE67-dihe-in -65.12, -16.72 -54.94, -46.13 APE12-dist-na 12.548 APE11-dist-na 8.981 APE10-dist-na 8.282 APE9-dist-in 5.911 None None None XRAY 1.797 0.19 0.226 A 306 269 4 0 0 0 [[613, 873]] 1.0 5ia4 TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR MET MET_HUMAN 6SDCA P08581 1052 1346 1390.0 88Z:1401 Type2 Inactive DFGout 14.755 9.992 BBAminus -145.61, -169.98 -156.56, 116.19 -59.96, -26.46 279.97, 77.13 50.32, -121.48 in-in in 8.796 Saltbr-in 2.861 HRD-in -66.32, -54.96 80.1, -13.51 in-out-in SNCioi out-in ActLoopNT-out 16.386 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.94, 108.39 APE9-dihe-in -108.81, 143.16 APE8-dihe-in -83.72, 68.12 APE8-rot-na 31.17 APE67-dihe-in -78.0, -5.37 -48.86, -37.15 APE12-dist-na 999.0 APE11-dist-na 13.258 APE10-dist-na 11.102 APE9-dist-in 7.166 D1228V None None XRAY 1.67 0.203 0.242 A 309 286 9 0 0 5 [[1078, 1339]] 1.0 6sdc TYR_MET_HUMAN TYR 1.5e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3LQ8A P08581 1053 1345 1390.0 88Z:1 Type2 Inactive DFGout 14.861 9.989 BBAminus -150.09, -172.74 -147.86, 117.02 -56.28, -26.81 274.5, 87.89 59.54, -126.97 in-in in 8.647 Saltbr-in 2.7 HRD-in -70.16, -54.71 79.85, -12.74 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.38, 117.69 APE9-dihe-in -124.2, 124.76 APE8-dihe-in -78.42, 71.53 APE8-rot-na 27.34 APE67-dihe-in -76.25, -4.88 -56.16, -37.64 APE12-dist-na 999.0 APE11-dist-na 14.007 APE10-dist-na 9.891 APE9-dist-in 7.129 None None None XRAY 2.02 0.194 0.252 A 302 278 15 0 0 8 [[1078, 1339]] 1.0 3lq8 TYR_MET_HUMAN TYR 6.4e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 6SD9A P08581 1062 1345 1390.0 88Z:1402 Type2 Inactive DFGout 14.875 10.089 BBAminus -142.16, -169.29 -149.74, 121.34 -65.96, -2.71 275.09, 79.25 44.01, -118.14 in-in in 8.835 Saltbr-in 3.063 HRD-in -63.65, -57.37 87.84, -32.21 in-out-in SNCioi out-in ActLoopNT-out 15.81 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.67, 97.49 APE9-dihe-in -110.0, 137.15 APE8-dihe-in -89.8, 72.46 APE8-rot-na 28.25 APE67-dihe-in -72.7, -14.18 -53.41, -37.28 APE12-dist-na 14.557 APE11-dist-na 14.701 APE10-dist-na 9.852 APE9-dist-in 7.607 None None None XRAY 2.35 0.212 0.27 A 309 265 19 0 0 9 [[1078, 1339]] 1.0 6sd9 TYR_MET_HUMAN TYR 6.9e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 88Z (Foretinib)

Total number of chains: 6
Active chains: 0
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 3 50.0% 6SDCA
DFGout None 3 50.0% 5IA4A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE STK10 STK10_HUMAN 6I2YA O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.574 None -142.6, 167.0 -107.59, -54.88 62.87, -46.4 275.81, 122.12 -90.27, -135.26 out-out out 10.946 Saltbr-out 9.656 HRD-in -100.04, -54.51 71.49, 1.4 out-in-out SNCoio in-out ActLoopNT-in 3.454 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -142.05 APE9-dihe-na -118.43, -179.23 APE8-dihe-in -77.25, 139.36 APE8-rot-in 315.91 APE67-dihe-in -58.76, -37.44 -65.9, -40.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.826 APE9-dist-out 27.363 None None None XRAY 2.56 0.264 0.283 A 302 279 15 0 0 10 [[36, 294]] 1.0 6i2y Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YB O94804 24 317 968.0 88Z:2000 Type2 Inactive DFGout 14.256 8.894 None -141.77, 169.33 -104.17, -54.09 61.03, 36.32 275.49, 122.46 -178.77, -139.27 out-none out 10.523 Saltbr-none 999.0 HRD-in -100.14, -55.33 72.94, 1.28 none-out-out SNCnoo out-out ActLoopNT-out 3.996 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 999.0 APE9-dihe-na -121.96, -178.86 APE8-dihe-in -77.3, 140.17 APE8-rot-none 999.0 APE67-dihe-in -63.08, -39.73 -66.89, -45.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 23.626 APE9-dist-out 26.545 None None None XRAY 2.56 0.264 0.283 B 302 277 17 0 0 10 [[36, 294]] 1.0 6i2y Homo sapiens STE_STK10_HUMAN STE 4.6e-94 320.5 1 257 257 174 175 176 178 180 65 81 85 154 156 155 157 219 202 197 196 195 194 193 192 191 111 Serine/threonine-protein kinase 10
TYR EPHA2 EPHA2_HUMAN 5IA4A P29317 605 877 976.0 88Z:1001 Type2 Inactive DFGout 13.811 6.305 None -141.42, 176.32 -148.43, 94.59 -58.84, -30.4 187.59, 75.41 105.04, 22.91 in-out in 9.571 Saltbr-out 4.687 HRD-in -75.95, -50.56 75.81, -10.01 out-out-in SNCooi out-in ActLoopNT-out 12.322 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.68, 164.18 APE9-dihe-in -115.64, 144.62 APE8-dihe-in -83.58, 93.81 APE8-rot-na 29.41 APE67-dihe-in -65.12, -16.72 -54.94, -46.13 APE12-dist-na 12.548 APE11-dist-na 8.981 APE10-dist-na 8.282 APE9-dist-in 5.911 None None None XRAY 1.797 0.19 0.226 A 306 269 4 0 0 0 [[613, 873]] 1.0 5ia4 Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR MET MET_HUMAN 6SDCA P08581 1052 1346 1390.0 88Z:1401 Type2 Inactive DFGout 14.755 9.992 BBAminus -145.61, -169.98 -156.56, 116.19 -59.96, -26.46 279.97, 77.13 50.32, -121.48 in-in in 8.796 Saltbr-in 2.861 HRD-in -66.32, -54.96 80.1, -13.51 in-out-in SNCioi out-in ActLoopNT-out 16.386 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.94, 108.39 APE9-dihe-in -108.81, 143.16 APE8-dihe-in -83.72, 68.12 APE8-rot-na 31.17 APE67-dihe-in -78.0, -5.37 -48.86, -37.15 APE12-dist-na 999.0 APE11-dist-na 13.258 APE10-dist-na 11.102 APE9-dist-in 7.166 D1228V None None XRAY 1.67 0.203 0.242 A 309 286 9 0 0 5 [[1078, 1339]] 1.0 6sdc Homo sapiens TYR_MET_HUMAN TYR 1.5e-91 312.8 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3LQ8A P08581 1053 1345 1390.0 88Z:1 Type2 Inactive DFGout 14.861 9.989 BBAminus -150.09, -172.74 -147.86, 117.02 -56.28, -26.81 274.5, 87.89 59.54, -126.97 in-in in 8.647 Saltbr-in 2.7 HRD-in -70.16, -54.71 79.85, -12.74 in-out-in SNCioi out-in ActLoopNT-out 16.446 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.38, 117.69 APE9-dihe-in -124.2, 124.76 APE8-dihe-in -78.42, 71.53 APE8-rot-na 27.34 APE67-dihe-in -76.25, -4.88 -56.16, -37.64 APE12-dist-na 999.0 APE11-dist-na 14.007 APE10-dist-na 9.891 APE9-dist-in 7.129 None None None XRAY 2.02 0.194 0.252 A 302 278 15 0 0 8 [[1078, 1339]] 1.0 3lq8 Homo sapiens TYR_MET_HUMAN TYR 6.4e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 6SD9A P08581 1062 1345 1390.0 88Z:1402 Type2 Inactive DFGout 14.875 10.089 BBAminus -142.16, -169.29 -149.74, 121.34 -65.96, -2.71 275.09, 79.25 44.01, -118.14 in-in in 8.835 Saltbr-in 3.063 HRD-in -63.65, -57.37 87.84, -32.21 in-out-in SNCioi out-in ActLoopNT-out 15.81 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.67, 97.49 APE9-dihe-in -110.0, 137.15 APE8-dihe-in -89.8, 72.46 APE8-rot-na 28.25 APE67-dihe-in -72.7, -14.18 -53.41, -37.28 APE12-dist-na 14.557 APE11-dist-na 14.701 APE10-dist-na 9.852 APE9-dist-in 7.607 None None None XRAY 2.35 0.212 0.27 A 309 265 19 0 0 9 [[1078, 1339]] 1.0 6sd9 Homo sapiens TYR_MET_HUMAN TYR 6.9e-92 313.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor

Ligand: 88Z (Foretinib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name