Ligand: 5L4

Total number of chains: 3
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5E8ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TKL TGFBR1 TGFR1_HUMAN 5E90A 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 200 - 499 0 None T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 5E8ZA 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 200 - 499 0 None T204D TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5E91A 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2

Ligand: 5L4

Total number of chains: 3
Active chains: 3
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 5E8ZA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TKL TGFBR1 TGFR1_HUMAN 5E90A 2.05 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 200 - 499 0 None T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F TGF-beta receptor type-1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 5E8ZA 1.51 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 200 - 499 0 None T204D TGF-beta receptor type-1 Homo sapiens
TKL TGFBR2 TGFR2_HUMAN 5E91A 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens

Ligand: 5L4

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism