TYR_ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Total number of chains: 9
Active chains: 2
Family: TYR
Uniprot: ROS1_HUMAN
Kinase Domain Residues: 1945 - 2217
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 5 55.6% 7Z5WA
DFGin ABAminus 2 22.2% 4UXLA
DFGin BLAminus 2 22.2% AF-P08922-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P08922-K1A 1937 2225 2347.0 No_ligand No_ligand Active DFGin 6.503 14.176 BLAminus -131.78, -171.22 50.11, 77.85 -90.9, 16.76 289.05, 93.86 -58.64, -34.44 in-in in 8.128 Saltbr-in 2.67 HRD-in -79.86, -43.16 65.46, -13.8 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.31, 130.42 APE9-dihe-in -125.1, 138.65 APE8-dihe-in -78.85, 63.38 APE8-rot-na 34.7 APE67-dihe-in -75.99, -10.64 -43.96, -39.9 APE12-dist-na 14.677 APE11-dist-na 10.657 APE10-dist-na 10.178 APE9-dist-in 6.988 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[1945, 2217]] 1.0 AF-P08922-K1 TYR_ROS1_HUMAN TYR 3.7e-95 324.1 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
AF-P08922-K3A 1937 2225 2347.0 No_ligand No_ligand Active DFGin 6.533 13.664 BLAminus -124.86, -166.98 52.38, 65.44 -81.98, 13.39 292.42, 96.61 -58.62, -31.96 in-in in 8.18 Saltbr-in 2.716 HRD-in -79.6, -44.14 64.31, -4.03 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.23, 134.03 APE9-dihe-in -139.58, 141.95 APE8-dihe-in -80.56, 61.13 APE8-rot-na 36.67 APE67-dihe-in -68.97, -13.98 -42.55, -41.95 APE12-dist-na 14.642 APE11-dist-na 10.885 APE10-dist-na 9.845 APE9-dist-in 6.764 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[1945, 2217]] 1.0 AF-P08922-K3 TYR_ROS1_HUMAN TYR 3.7e-95 324.1 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
3ZBFA 1934 2230 2347.0 VGH:3000 Type1 Inactive DFGin 6.553 14.56 ABAminus -129.17, -37.91 -114.96, 123.49 -118.51, 31.51 297.44, 69.18 -62.83, -16.28 in-in in 8.506 Saltbr-in 3.499 HRD-in -86.85, -45.31 73.51, 7.34 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -30.1 APE8-dihe-in -94.83, 74.5 APE8-rot-na 33.93 APE67-dihe-in -65.41, -17.17 -63.88, -31.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.1 None None None XRAY 2.2 0.236 0.282 A 322 282 15 0 0 12 [[1945, 2217]] 1.0 3zbf TYR_ROS1_HUMAN TYR 5.4e-95 323.5 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
4UXLA 1934 2230 2347.0 5P8:3230 Type1 Inactive DFGin 6.194 13.993 ABAminus -141.3, 11.29 -144.65, 99.59 -104.59, 30.23 307.24, 85.25 -59.55, -21.07 in-out in 7.952 Saltbr-out 4.12 HRD-in -84.61, -43.72 73.98, 0.0 out-in-out SNCoio in-out ActLoopNT-in 2.714 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaao APE10-dihe-out 79.22, 179.05 APE9-dihe-out 178.0, -54.94 APE8-dihe-in -73.51, 76.26 APE8-rot-na 29.99 APE67-dihe-in -70.8, -16.84 -65.31, -30.57 APE12-dist-na 13.69 APE11-dist-na 10.472 APE10-dist-na 9.726 APE9-dist-out 9.238 None None None XRAY 2.4 0.211 0.281 A 322 289 8 0 0 8 [[1945, 2217]] 1.0 4uxl TYR_ROS1_HUMAN TYR 5.4e-95 323.5 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
7Z5WA 1937 2225 2347.0 IDW:2301 Type1 Inactive DFGin 6.695 14.321 None -94.7, -152.87 -20.72, 134.4 -104.55, 141.7 300.47, 74.83 -69.24, 999.0 in-out in 7.952 Saltbr-out 4.61 HRD-in -58.16, -44.63 77.6, -17.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.24 APE8-dihe-in -84.74, 70.79 APE8-rot-na 30.54 APE67-dihe-in -61.34, -19.9 -51.55, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.558 None None None XRAY 2.254 0.226 0.276 A 331 271 18 0 0 18 [[1945, 2217]] 1.0 7z5w TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
7Z5WB 1937 2226 2347.0 IDW:2301 Type1 Inactive DFGin 6.836 14.268 None -118.79, -153.42 52.77, -75.92 69.95, 35.45 304.69, 93.82 -135.83, 999.0 in-out in 7.96 Saltbr-out 5.104 HRD-in -71.29, -42.41 71.74, -4.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.77 APE8-dihe-in -83.18, 59.59 APE8-rot-na 31.32 APE67-dihe-in -66.39, -14.66 -46.18, -41.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.83 None None None XRAY 2.254 0.226 0.276 B 331 272 18 0 0 18 [[1945, 2217]] 1.0 7z5w TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
7Z5XA 1937 2225 2347.0 AWJ:2301 Type1 Inactive DFGin 7.14 14.326 None -115.65, -151.87 19.28, 91.72 -103.73, 999.0 300.69, 79.11 999.0, 999.0 in-in in 7.888 Saltbr-in 3.01 HRD-in -78.13, -45.97 75.44, -15.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.49 APE8-dihe-in -89.41, 63.11 APE8-rot-na 11.43 APE67-dihe-in -63.61, -20.18 -48.49, -41.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.638 None None None XRAY 2.035 0.229 0.266 A 331 270 19 0 0 19 [[1945, 2217]] 1.0 7z5x TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
7Z5XB 1937 2226 2347.0 AWJ:2301 Type1 Inactive DFGin 7.15 14.376 None -105.58, -155.45 22.98, 111.73 -123.72, 999.0 298.95, 81.3 999.0, 999.0 in-in in 7.872 Saltbr-in 3.005 HRD-in -72.3, -46.74 74.95, -14.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.07 APE8-dihe-in -86.07, 63.61 APE8-rot-na 10.54 APE67-dihe-in -63.94, -20.45 -49.44, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.673 None None None XRAY 2.035 0.229 0.266 B 331 271 19 0 0 19 [[1945, 2217]] 1.0 7z5x TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
9QEKA 1934 2229 2347.0 A1I6Z:62302 Type1 Inactive DFGin 6.419 14.236 None -128.5, -154.51 48.35, 74.6 -100.28, 999.0 297.06, 101.75 999.0, 999.0 in-out in 7.958 Saltbr-out 4.538 HRD-in -77.5, -45.64 72.03, 12.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 125.32 APE9-dihe-in -104.47, 106.45 APE8-dihe-in -80.98, 70.72 APE8-rot-na 35.17 APE67-dihe-in -71.98, -20.47 -66.89, -32.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.326 G2032R None None XRAY 2.205 0.203 0.272 A 301 274 22 0 0 18 [[1945, 2217]] 1.0 9qek TYR_ROS1_HUMAN TYR 2.3e-93 318.2 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS

TYR_ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Total number of chains: 9
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 5 55.6% 7Z5WA
DFGin ABAminus 2 22.2% 4UXLA
DFGin BLAminus 2 22.2% AF-P08922-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ROS1_HUMAN AF-P08922-K1A P08922 1937 2225 2347.0 No_ligand No_ligand Active DFGin 6.503 14.176 BLAminus -131.78, -171.22 50.11, 77.85 -90.9, 16.76 289.05, 93.86 -58.64, -34.44 in-in in 8.128 Saltbr-in 2.67 HRD-in -79.86, -43.16 65.46, -13.8 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -65.31, 130.42 APE9-dihe-in -125.1, 138.65 APE8-dihe-in -78.85, 63.38 APE8-rot-na 34.7 APE67-dihe-in -75.99, -10.64 -43.96, -39.9 APE12-dist-na 14.677 APE11-dist-na 10.657 APE10-dist-na 10.178 APE9-dist-in 6.988 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[1945, 2217]] 1.0 AF-P08922-K1 Homo sapiens TYR_ROS1_HUMAN TYR 3.7e-95 324.1 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN AF-P08922-K3A P08922 1937 2225 2347.0 No_ligand No_ligand Active DFGin 6.533 13.664 BLAminus -124.86, -166.98 52.38, 65.44 -81.98, 13.39 292.42, 96.61 -58.62, -31.96 in-in in 8.18 Saltbr-in 2.716 HRD-in -79.6, -44.14 64.31, -4.03 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.23, 134.03 APE9-dihe-in -139.58, 141.95 APE8-dihe-in -80.56, 61.13 APE8-rot-na 36.67 APE67-dihe-in -68.97, -13.98 -42.55, -41.95 APE12-dist-na 14.642 APE11-dist-na 10.885 APE10-dist-na 9.845 APE9-dist-in 6.764 None None None AF2 -1.0 1.0 1.0 A 289 289 0 0 0 0 [[1945, 2217]] 1.0 AF-P08922-K3 Homo sapiens TYR_ROS1_HUMAN TYR 3.7e-95 324.1 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN 3ZBFA P08922 1934 2230 2347.0 VGH:3000 Type1 Inactive DFGin 6.553 14.56 ABAminus -129.17, -37.91 -114.96, 123.49 -118.51, 31.51 297.44, 69.18 -62.83, -16.28 in-in in 8.506 Saltbr-in 3.499 HRD-in -86.85, -45.31 73.51, 7.34 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -30.1 APE8-dihe-in -94.83, 74.5 APE8-rot-na 33.93 APE67-dihe-in -65.41, -17.17 -63.88, -31.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.1 None None None XRAY 2.2 0.236 0.282 A 322 282 15 0 0 12 [[1945, 2217]] 1.0 3zbf Homo sapiens TYR_ROS1_HUMAN TYR 5.4e-95 323.5 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN 4UXLA P08922 1934 2230 2347.0 5P8:3230 Type1 Inactive DFGin 6.194 13.993 ABAminus -141.3, 11.29 -144.65, 99.59 -104.59, 30.23 307.24, 85.25 -59.55, -21.07 in-out in 7.952 Saltbr-out 4.12 HRD-in -84.61, -43.72 73.98, 0.0 out-in-out SNCoio in-out ActLoopNT-in 2.714 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaao APE10-dihe-out 79.22, 179.05 APE9-dihe-out 178.0, -54.94 APE8-dihe-in -73.51, 76.26 APE8-rot-na 29.99 APE67-dihe-in -70.8, -16.84 -65.31, -30.57 APE12-dist-na 13.69 APE11-dist-na 10.472 APE10-dist-na 9.726 APE9-dist-out 9.238 None None None XRAY 2.4 0.211 0.281 A 322 289 8 0 0 8 [[1945, 2217]] 1.0 4uxl Homo sapiens TYR_ROS1_HUMAN TYR 5.4e-95 323.5 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN 7Z5WA P08922 1937 2225 2347.0 IDW:2301 Type1 Inactive DFGin 6.695 14.321 None -94.7, -152.87 -20.72, 134.4 -104.55, 141.7 300.47, 74.83 -69.24, 999.0 in-out in 7.952 Saltbr-out 4.61 HRD-in -58.16, -44.63 77.6, -17.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.24 APE8-dihe-in -84.74, 70.79 APE8-rot-na 30.54 APE67-dihe-in -61.34, -19.9 -51.55, -45.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.558 None None None XRAY 2.254 0.226 0.276 A 331 271 18 0 0 18 [[1945, 2217]] 1.0 7z5w Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN 7Z5WB P08922 1937 2226 2347.0 IDW:2301 Type1 Inactive DFGin 6.836 14.268 None -118.79, -153.42 52.77, -75.92 69.95, 35.45 304.69, 93.82 -135.83, 999.0 in-out in 7.96 Saltbr-out 5.104 HRD-in -71.29, -42.41 71.74, -4.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -59.77 APE8-dihe-in -83.18, 59.59 APE8-rot-na 31.32 APE67-dihe-in -66.39, -14.66 -46.18, -41.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.83 None None None XRAY 2.254 0.226 0.276 B 331 272 18 0 0 18 [[1945, 2217]] 1.0 7z5w Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN 7Z5XA P08922 1937 2225 2347.0 AWJ:2301 Type1 Inactive DFGin 7.14 14.326 None -115.65, -151.87 19.28, 91.72 -103.73, 999.0 300.69, 79.11 999.0, 999.0 in-in in 7.888 Saltbr-in 3.01 HRD-in -78.13, -45.97 75.44, -15.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.49 APE8-dihe-in -89.41, 63.11 APE8-rot-na 11.43 APE67-dihe-in -63.61, -20.18 -48.49, -41.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.638 None None None XRAY 2.035 0.229 0.266 A 331 270 19 0 0 19 [[1945, 2217]] 1.0 7z5x Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN 7Z5XB P08922 1937 2226 2347.0 AWJ:2301 Type1 Inactive DFGin 7.15 14.376 None -105.58, -155.45 22.98, 111.73 -123.72, 999.0 298.95, 81.3 999.0, 999.0 in-in in 7.872 Saltbr-in 3.005 HRD-in -72.3, -46.74 74.95, -14.87 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.07 APE8-dihe-in -86.07, 63.61 APE8-rot-na 10.54 APE67-dihe-in -63.94, -20.45 -49.44, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.673 None None None XRAY 2.035 0.229 0.266 B 331 271 19 0 0 19 [[1945, 2217]] 1.0 7z5x Homo sapiens TYR_ROS1_HUMAN TYR 6e-95 323.4 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS
ROS1_HUMAN 9QEKA P08922 1934 2229 2347.0 A1I6Z:62302 Type1 Inactive DFGin 6.419 14.236 None -128.5, -154.51 48.35, 74.6 -100.28, 999.0 297.06, 101.75 999.0, 999.0 in-out in 7.958 Saltbr-out 4.538 HRD-in -77.5, -45.64 72.03, 12.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 125.32 APE9-dihe-in -104.47, 106.45 APE8-dihe-in -80.98, 70.72 APE8-rot-na 35.17 APE67-dihe-in -71.98, -20.47 -66.89, -32.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.326 G2032R None None XRAY 2.205 0.203 0.272 A 301 274 22 0 0 18 [[1945, 2217]] 1.0 9qek Homo sapiens TYR_ROS1_HUMAN TYR 2.3e-93 318.2 3 260 258 2101 2102 2103 2105 2107 1980 1997 2001 2076 2078 2077 2079 2143 2131 2126 2125 2124 2123 2122 2121 2120 2027 Proto-oncogene tyrosine-protein kinase ROS

TYR_ROS1 (Proto-oncogene tyrosine-protein kinase ROS)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name