TYR_PTK2 (Focal adhesion kinase 1)

Total number of chains: 53
Active chains: 2
Family: TYR
Uniprot: FAK1_HUMAN
Kinase Domain Residues: 422 - 678
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 27 50.9% 4GU6A
DFGin BLAminus 9 17.0% AF-Q05397-K1A
DFGin ABAminus 7 13.2% 6YVYA
DFGout None 3 5.7% 4K9YA
None None 3 5.7% 6YVSC
DFGout BBAminus 2 3.8% 4KAOB
DFGin BLBminus 1 1.9% 2IJMB
DFGinter None 1 1.9% 4EBWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-Q05397-K1A 414 686 1052.0 No_ligand No_ligand Active DFGin 6.28 14.616 BLAminus -130.37, -169.73 56.83, 67.25 -84.76, 10.0 286.01, 85.02 -60.3, -29.65 in-in in 7.772 Saltbr-in 2.659 HRD-in -80.45, -42.93 64.64, -5.62 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.41, 131.91 APE9-dihe-in -132.13, 129.29 APE8-dihe-in -80.18, 69.23 APE8-rot-na 34.6 APE67-dihe-in -69.07, -14.62 -44.93, -40.49 APE12-dist-na 13.969 APE11-dist-na 10.284 APE10-dist-na 10.381 APE9-dist-in 7.024 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[422, 678]] 1.0 AF-Q05397-K1 TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
AF-Q05397-K3A 414 686 1052.0 No_ligand No_ligand Active DFGin 5.937 14.109 BLAminus -132.43, -167.86 50.51, 75.71 -84.77, 10.13 293.07, 91.02 -61.11, -27.99 in-in in 8.107 Saltbr-in 2.703 HRD-in -79.74, -43.96 66.37, 0.29 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.22, 136.4 APE9-dihe-in -136.53, 152.75 APE8-dihe-in -80.89, 62.21 APE8-rot-na 36.87 APE67-dihe-in -68.15, -14.35 -42.6, -41.72 APE12-dist-na 14.027 APE11-dist-na 10.645 APE10-dist-na 10.954 APE9-dist-in 6.74 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[422, 678]] 1.0 AF-Q05397-K3 TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
9SDIA 414 686 1052.0 A1JNJ:705 Type1 Inactive DFGin 3.565 13.297 ABAminus -111.82, -18.24 -124.75, 169.76 -130.67, -27.74 302.6, 98.83 -32.6, 999.0 in-out in 7.685 Saltbr-out 4.447 HRD-in -90.69, -45.97 77.93, -2.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 144.05 APE8-dihe-in -93.73, 62.5 APE8-rot-na 18.7 APE67-dihe-in -65.12, -21.79 -51.01, -41.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.423 None None None XRAY 2.53 0.184 0.241 A 277 256 17 0 0 17 [[422, 678]] 1.0 9sdi TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
3PXKA 415 687 1052.0 PXK:701 Type1 Inactive DFGin 6.144 15.31 ABAminus -120.11, -2.63 -137.28, 131.22 -129.5, 22.87 289.37, 86.78 -73.41, 999.0 in-in in 8.065 Saltbr-in 2.707 HRD-in -73.28, -47.59 77.2, -9.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.04 APE8-dihe-in -81.54, 63.47 APE8-rot-na 31.8 APE67-dihe-in -69.25, -13.88 -43.54, -40.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.732 P410G None None XRAY 1.79 0.185 0.216 A 282 256 17 0 0 17 [[422, 678]] 1.0 3pxk TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
3PXKB 414 687 1052.0 PXK:702 Type1 Inactive DFGin 6.059 14.414 ABAminus -117.18, -5.52 -138.67, 135.85 -133.31, 18.42 288.86, 88.66 -64.83, -34.02 in-in in 7.797 Saltbr-in 2.662 HRD-in -73.1, -47.41 72.71, -3.69 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.84 APE8-dihe-in -82.41, 66.29 APE8-rot-na 24.52 APE67-dihe-in -65.63, -9.44 -49.9, -47.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.785 P410G None None XRAY 1.79 0.185 0.216 B 282 258 16 0 0 16 [[422, 678]] 1.0 3pxk TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YT6A 414 686 1052.0 PKE:701 Type1 Inactive DFGin 6.167 15.301 ABAminus -125.68, 11.47 -143.86, 126.64 -128.72, 27.06 294.54, 78.63 -86.25, -18.25 in-in in 7.949 Saltbr-in 2.705 HRD-in -77.73, -46.86 79.23, -10.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.13 APE8-dihe-in -80.24, 58.16 APE8-rot-na 31.27 APE67-dihe-in -67.36, -9.68 -46.75, -46.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.799 None None None XRAY 1.537 0.191 0.212 A 282 256 17 0 0 15 [[422, 678]] 1.0 6yt6 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YT6B 414 686 1052.0 PKE:701 Type1 Inactive DFGin 6.176 14.965 ABAminus -123.82, 10.73 -142.81, 128.01 -131.84, 29.41 294.35, 82.53 -81.12, 159.2 in-in in 7.619 Saltbr-in 2.716 HRD-in -78.8, -45.97 74.91, -5.57 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 118.15 APE9-dihe-in -105.54, 143.24 APE8-dihe-in -81.67, 62.69 APE8-rot-na 30.59 APE67-dihe-in -67.33, -11.15 -47.56, -44.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.695 APE9-dist-in 7.832 None None None XRAY 1.537 0.191 0.212 B 282 258 15 0 0 15 [[422, 678]] 1.0 6yt6 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVSA 414 686 1052.0 PVT:701 Type1 Inactive DFGin 7.037 16.11 ABAminus -123.36, 1.14 -129.41, 122.1 -120.04, 23.57 289.1, 75.16 -54.09, -36.16 in-out in 8.801 Saltbr-out 4.042 HRD-in -69.73, -49.55 71.97, 3.79 out-in-none SNCoin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 152.96 APE9-dihe-in -82.83, 138.18 APE8-dihe-in -84.21, 64.83 APE8-rot-na 34.21 APE67-dihe-in -64.52, -14.48 -50.82, -42.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.46 APE9-dist-in 7.91 None None None XRAY 1.81 0.193 0.215 A 282 260 13 0 0 13 [[422, 678]] 1.0 6yvs TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVYA 412 686 1052.0 P1E:701 Type1 Inactive DFGin 6.923 16.058 ABAminus -123.33, 0.59 -123.32, 123.05 -122.83, 25.97 286.06, 70.66 -56.13, -41.38 in-out in 8.868 Saltbr-out 4.165 HRD-in -73.46, -49.62 72.4, 1.81 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.5, 136.03 APE9-dihe-in -79.34, 137.37 APE8-dihe-in -82.93, 65.49 APE8-rot-na 31.34 APE67-dihe-in -64.99, -13.14 -47.78, -44.49 APE12-dist-na 999.0 APE11-dist-na 9.419 APE10-dist-na 11.972 APE9-dist-in 7.612 None None None XRAY 1.918 0.215 0.235 A 282 265 10 0 0 10 [[422, 678]] 1.0 6yvy TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4GU9B 415 683 1052.0 4GU:701 Type1 Inactive DFGin 6.61 16.037 BLAminus -125.5, -158.26 48.51, 68.16 -94.75, 10.99 282.95, 68.33 -94.28, -13.76 in-in in 7.913 Saltbr-in 3.357 HRD-in -71.95, -46.82 78.11, -13.81 in-out-out SNCioo out-out ActLoopNT-out 12.74 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.17 APE8-dihe-in -81.64, 64.78 APE8-rot-na 30.94 APE67-dihe-in -68.87, -11.47 -50.39, -42.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.984 None None None XRAY 2.4 0.18 0.221 B 279 255 14 0 0 12 [[422, 678]] 1.0 4gu9 TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4K8AA 414 683 1052.0 K8A:701 Type1 Inactive DFGin 6.983 15.401 BLAminus -121.47, -166.12 54.91, 76.43 -107.93, 50.57 283.28, 87.55 -142.37, 999.0 in-out in 7.721 Saltbr-out 3.639 HRD-in -64.7, -43.35 74.08, -12.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.33 APE8-dihe-in -76.77, 64.66 APE8-rot-na 29.01 APE67-dihe-in -72.21, -11.17 -51.86, -41.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.826 None None None XRAY 2.91 0.184 0.224 A 279 251 19 0 0 17 [[422, 678]] 1.0 4k8a TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4K8AB 414 684 1052.0 K8A:701 Type1 Inactive DFGin 6.914 15.705 BLAminus -115.4, -153.96 47.26, 77.74 -107.18, 24.9 279.88, 84.24 -112.96, -15.47 in-out in 7.762 Saltbr-out 3.8 HRD-in -64.66, -47.31 78.56, -14.07 out-out-out SNCooo out-out ActLoopNT-out 12.804 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.66 APE8-dihe-in -75.55, 65.45 APE8-rot-na 29.5 APE67-dihe-in -69.34, -11.69 -52.26, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.054 None None None XRAY 2.91 0.184 0.224 B 279 258 13 0 0 13 [[422, 678]] 1.0 4k8a TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4KABB 414 684 1052.0 4KA:701 Type1 Inactive DFGin 6.57 15.738 BLAminus -121.46, -160.12 49.21, 75.34 -97.29, 8.37 281.34, 75.31 -102.38, -7.12 in-in in 7.717 Saltbr-in 3.033 HRD-in -73.34, -42.86 75.98, -10.51 in-out-out SNCioo out-out ActLoopNT-out 12.701 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.03 APE8-dihe-in -79.93, 66.69 APE8-rot-na 28.5 APE67-dihe-in -72.71, -9.14 -55.44, -38.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.823 None None None XRAY 2.71 0.173 0.219 B 279 258 13 0 0 12 [[422, 678]] 1.0 4kab TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
2ETMA 415 686 1052.0 7PY:131 Type1 Inactive DFGin 6.194 15.906 BLAminus -139.03, -155.38 54.99, 56.46 -78.64, -20.58 280.28, 75.46 -75.88, -7.09 in-out in 7.691 Saltbr-out 4.019 HRD-in -68.86, -57.97 98.34, -20.82 out-out-out SNCooo out-out ActLoopNT-out 12.707 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 126.3 APE9-dihe-in -124.3, 115.41 APE8-dihe-in -74.42, 59.49 APE8-rot-na 32.57 APE67-dihe-in -67.6, -4.02 -51.51, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.265 APE9-dist-out 9.524 None None None XRAY 2.3 0.215 0.295 A 281 262 10 0 0 10 [[422, 678]] 1.0 2etm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
2ETMB 413 689 1052.0 7PY:132 Type1 Inactive DFGin 6.508 15.636 BLAminus -131.46, -154.81 60.14, 64.69 -93.52, 10.54 284.78, 95.79 -111.33, 2.27 in-in in 7.694 Saltbr-in 2.726 HRD-in -70.42, -51.89 89.97, -15.7 in-out-out SNCioo out-out ActLoopNT-out 11.88 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.44 APE8-dihe-out -74.95, 49.29 APE8-rot-na 34.9 APE67-dihe-in -71.5, -6.36 -45.52, -37.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.375 None None None XRAY 2.3 0.215 0.295 B 281 263 14 0 0 14 [[422, 678]] 1.0 2etm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVYB 415 686 1052.0 P1E:701 Type1 Inactive DFGin 6.76 16.154 BLAminus -125.37, -159.56 46.15, 75.22 -98.8, 22.63 289.45, 61.98 -103.7, -1.46 in-in in 8.082 Saltbr-in 2.884 HRD-in -68.13, -50.71 78.23, -5.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.05 APE8-dihe-in -81.82, 62.53 APE8-rot-na 30.96 APE67-dihe-in -65.78, -13.58 -48.49, -45.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.28 None None None XRAY 1.918 0.215 0.235 B 282 257 15 0 0 15 [[422, 678]] 1.0 6yvy TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
2IJMB 414 689 1052.0 ADP:800 ATPlike Inactive DFGin 6.323 15.493 BLBminus -110.71, -163.98 67.21, 81.0 -117.82, 145.96 283.77, 97.43 -64.08, -51.52 in-out in 7.648 Saltbr-out 3.676 HRD-in -77.75, -52.2 82.75, -4.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -36.05 APE8-dihe-out -75.82, 46.85 APE8-rot-na 30.48 APE67-dihe-in -72.2, -5.65 -47.65, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.699 None None None XRAY 2.187 0.211 0.271 B 281 261 15 0 0 15 [[422, 678]] 1.0 2ijm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
2IJMA 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.335 15.255 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.602 Saltbr-in 2.544 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.531 None None None XRAY 2.187 0.211 0.271 A 281 260 15 0 0 15 [[422, 678]] 1.0 2ijm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
7PI4DDD 415 687 1052.0 No_ligand No_ligand Inactive DFGin 6.642 15.76 None -89.21, -168.8 -53.97, 129.66 -63.34, -43.26 292.53, 5.46 -58.42, -48.1 in-in in 7.459 Saltbr-in 2.722 HRD-in -72.06, -49.67 76.25, -8.72 in-out-out SNCioo out-out ActLoopNT-out 10.484 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.81 APE9-dihe-in -72.54, 128.52 APE8-dihe-in -81.98, 69.32 APE8-rot-na 34.58 APE67-dihe-in -74.94, -9.99 -55.31, -40.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.095 APE9-dist-out 8.638 None None None XRAY 2.24 0.198 0.251 DDD 273 264 9 0 0 9 [[422, 678]] 1.0 7pi4 TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
9SDIB 414 685 1052.0 No_ligand No_ligand Inactive DFGin 4.005 13.17 None -97.64, -137.83 -54.67, 146.24 -100.48, 130.01 327.08, 92.25 63.05, 999.0 in-out in 8.106 Saltbr-out 8.294 HRD-in -82.43, -51.16 74.28, 13.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.88 APE8-dihe-in -70.36, 61.66 APE8-rot-na 27.15 APE67-dihe-in -67.38, -13.24 -53.44, -40.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.978 None None None XRAY 2.53 0.184 0.241 B 277 255 17 0 0 17 [[422, 678]] 1.0 9sdi TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
3BZ3A 414 689 1052.0 YAM:1 Type1 Inactive DFGin 6.672 15.85 None -79.02, -179.99 -56.66, 136.15 -73.84, -38.07 287.89, 7.91 -61.02, -47.25 in-in in 7.527 Saltbr-in 2.589 HRD-in -85.54, -56.7 90.17, -10.54 in-out-out SNCioo out-out ActLoopNT-out 10.556 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.15 APE8-dihe-in -80.58, 72.72 APE8-rot-na 30.9 APE67-dihe-in -70.02, -11.94 -54.79, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 None None None XRAY 2.2 0.16 0.234 A 276 259 17 0 0 13 [[422, 678]] 1.0 3bz3 TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4GU9A 414 685 1052.0 4GU:701 Type1 Inactive DFGin 6.699 15.701 None -123.83, 12.04 -117.35, 108.51 -134.16, 999.0 294.29, 94.21 999.0, 999.0 in-in in 7.769 Saltbr-in 3.492 HRD-in -72.07, -46.62 76.1, -11.95 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.49 APE8-dihe-in -81.89, 65.04 APE8-rot-na 31.19 APE67-dihe-in -69.72, -10.34 -49.89, -42.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.656 None None None XRAY 2.4 0.18 0.221 A 279 252 20 0 0 18 [[422, 678]] 1.0 4gu9 TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4KABA 412 686 1052.0 4KA:701 Type1 Inactive DFGin 6.39 15.555 None -111.52, -14.16 -107.87, 122.87 -138.65, 999.0 293.6, 93.91 999.0, 999.0 in-in in 7.705 Saltbr-in 3.059 HRD-in -73.14, -43.25 75.58, -10.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.68 APE8-dihe-in -81.37, 68.28 APE8-rot-na 28.59 APE67-dihe-in -69.97, -11.06 -55.99, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.54 None None None XRAY 2.71 0.173 0.219 A 279 255 20 0 0 18 [[422, 678]] 1.0 4kab TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6I8ZA 414 688 1052.0 H82:701 Type1 Inactive DFGin 6.534 15.739 None -73.65, -177.37 -59.05, 135.57 -69.93, -28.35 299.91, 168.26 -68.89, -44.51 in-in in 7.601 Saltbr-in 2.804 HRD-in -70.2, -51.5 74.46, -8.27 in-out-out SNCioo out-out ActLoopNT-out 10.52 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.99 APE8-dihe-in -84.17, 66.78 APE8-rot-na 36.24 APE67-dihe-in -65.96, -15.87 -53.48, -40.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.416 None None None XRAY 1.99 0.185 0.222 A 281 261 14 0 0 14 [[422, 678]] 1.0 6i8z TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4I4EA 414 686 1052.0 1BQ:1000 Type1 Inactive DFGin 6.79 16.342 None -103.61, -97.99 -1.1, -106.34 55.03, 999.0 299.48, 75.74 999.0, 999.0 in-out in 7.698 Saltbr-out 3.748 HRD-in -79.84, -49.84 80.8, -2.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.29 APE8-dihe-in -79.67, 64.72 APE8-rot-na 33.35 APE67-dihe-in -67.06, -11.75 -53.27, -42.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.263 None None None XRAY 1.55 0.166 0.189 A 281 254 19 0 0 18 [[422, 678]] 1.0 4i4e TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4GU6A 414 686 1052.0 10N:701 Type1 Inactive DFGin 6.725 15.721 None -78.95, -178.49 -53.69, 136.88 -71.82, -34.41 298.6, 168.4 -65.26, -49.08 in-in in 7.521 Saltbr-in 2.697 HRD-in -71.62, -48.61 84.03, -17.12 in-out-out SNCioo out-out ActLoopNT-out 9.638 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -143.19, 149.54 APE9-dihe-in -51.38, 136.95 APE8-dihe-in -84.93, 56.73 APE8-rot-na 35.61 APE67-dihe-in -63.59, -13.44 -54.64, -43.26 APE12-dist-na 13.418 APE11-dist-na 11.77 APE10-dist-na 15.228 APE9-dist-out 9.376 None None None XRAY 1.95 0.171 0.194 A 282 271 2 0 0 0 [[422, 678]] 1.0 4gu6 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4GU6B 415 686 1052.0 10N:701 Type1 Inactive DFGin 6.732 15.951 None -79.45, -179.1 -51.77, 131.29 -67.64, -33.77 299.56, 166.92 -65.8, -45.35 in-in in 7.527 Saltbr-in 2.728 HRD-in -73.02, -50.64 78.02, -11.87 in-out-out SNCioo out-out ActLoopNT-out 10.862 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.41 APE8-dihe-in -75.09, 60.15 APE8-rot-na 31.47 APE67-dihe-in -63.51, -13.22 -52.64, -44.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.244 None None None XRAY 1.95 0.171 0.194 B 282 258 14 0 0 14 [[422, 678]] 1.0 4gu6 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YOJA 414 686 1052.0 P4N:701 Type1 Inactive DFGin 6.517 15.964 None -76.38, -175.19 -62.53, 137.68 -71.29, -34.87 295.0, 178.59 -63.41, -49.08 in-in in 7.419 Saltbr-in 2.765 HRD-in -74.52, -48.86 75.74, -8.06 in-out-none SNCion out-none ActLoopNT-out 10.504 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.61 APE8-dihe-in -85.09, 65.79 APE8-rot-na 30.31 APE67-dihe-in -64.59, -10.84 -48.78, -45.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.798 None None None XRAY 1.361 0.172 0.198 A 282 259 14 0 0 14 [[422, 678]] 1.0 6yoj TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YQ1A 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.772 15.904 None -76.89, 179.45 -55.75, 133.99 -70.6, -39.73 296.27, 174.79 -61.86, -42.84 in-in in 7.546 Saltbr-in 2.913 HRD-in -71.31, -56.22 78.91, -8.0 in-out-out SNCioo out-out ActLoopNT-out 12.154 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -50.8 APE9-dihe-in -136.97, 142.61 APE8-dihe-in -82.64, 66.53 APE8-rot-na 31.58 APE67-dihe-in -67.94, -11.22 -48.21, -42.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.47 APE9-dist-out 8.283 None None None XRAY 1.784 0.184 0.214 A 282 269 3 0 0 3 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YQ1B 411 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.896 16.008 None -76.83, 179.03 -54.23, 132.73 -71.29, -38.79 295.55, 174.7 -61.35, -42.29 in-in in 7.53 Saltbr-in 2.865 HRD-in -73.31, -54.59 78.37, -7.32 in-out-out SNCioo out-out ActLoopNT-out 12.023 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -48.66, 142.89 APE9-dihe-in -137.31, 146.9 APE8-dihe-in -83.8, 68.09 APE8-rot-na 31.86 APE67-dihe-in -70.2, -9.5 -48.58, -42.33 APE12-dist-na 13.399 APE11-dist-na 16.849 APE10-dist-na 14.837 APE9-dist-out 8.254 None None None XRAY 1.784 0.184 0.214 B 282 273 3 0 0 3 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YQ1C 412 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.581 15.841 None -75.66, -177.24 -55.77, 133.76 -67.84, -41.72 295.72, 176.78 -60.36, -44.8 in-in in 7.615 Saltbr-in 2.857 HRD-in -71.08, -53.73 81.02, -10.73 in-out-out SNCioo out-out ActLoopNT-out 10.633 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -15.64 APE9-dihe-in -96.3, 121.87 APE8-dihe-in -82.84, 65.74 APE8-rot-na 33.11 APE67-dihe-in -65.58, -12.51 -46.04, -44.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.989 APE9-dist-out 8.832 None None None XRAY 1.784 0.184 0.214 C 282 264 11 0 0 11 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YQ1D 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.657 15.854 None -76.76, -177.88 -55.33, 133.74 -70.22, -39.58 296.95, 175.58 -62.46, -41.81 in-in in 7.523 Saltbr-in 2.881 HRD-in -70.74, -53.46 79.06, -11.18 in-out-out SNCioo out-out ActLoopNT-out 11.813 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -83.88, 65.98 APE8-rot-na 32.0 APE67-dihe-in -68.39, -9.16 -46.59, -43.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.43 None None None XRAY 1.784 0.184 0.214 D 282 258 14 0 0 14 [[422, 678]] 1.0 6yq1 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YR9A 415 686 1052.0 P9K:701 Type1 Inactive DFGin 6.693 15.656 None -72.52, -178.45 -57.73, 135.79 -72.85, -37.79 298.07, 168.43 -63.0, -44.27 in-in in 7.537 Saltbr-in 2.756 HRD-in -68.47, -56.13 84.19, -11.31 in-out-out SNCioo out-out ActLoopNT-out 11.971 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.92 APE8-dihe-in -80.86, 65.41 APE8-rot-na 32.51 APE67-dihe-in -65.96, -9.35 -56.05, -39.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.807 None None None XRAY 1.925 0.193 0.218 A 282 260 12 0 0 12 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YR9B 414 684 1052.0 P9K:701 Type1 Inactive DFGin 6.541 15.688 None -72.19, -175.35 -58.86, 135.81 -72.29, -35.25 299.46, 167.83 -65.13, -41.68 in-in in 7.487 Saltbr-in 2.81 HRD-in -74.4, -54.18 84.68, -14.66 in-out-out SNCioo out-out ActLoopNT-out 10.601 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -51.93 APE9-dihe-in -104.69, 112.5 APE8-dihe-in -81.62, 64.47 APE8-rot-na 30.93 APE67-dihe-in -65.67, -8.67 -53.83, -41.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.446 APE9-dist-out 8.987 None None None XRAY 1.925 0.193 0.218 B 282 258 13 0 0 13 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YR9C 414 686 1052.0 P9K:701 Type1 Inactive DFGin 6.707 15.696 None -74.62, -175.14 -58.39, 136.31 -73.32, -36.06 298.17, 169.43 -64.54, -38.88 in-in in 7.476 Saltbr-in 2.802 HRD-in -67.84, -54.81 84.4, -10.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.96 APE8-dihe-in -83.91, 65.47 APE8-rot-na 32.43 APE67-dihe-in -66.56, -9.09 -55.03, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.579 None None None XRAY 1.925 0.193 0.218 C 282 258 15 0 0 15 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YR9D 412 685 1052.0 P9K:701 Type1 Inactive DFGin 6.849 15.9 None -73.97, -177.5 -59.32, 135.48 -74.09, -34.16 299.25, 167.14 -64.12, -40.48 in-in in 7.483 Saltbr-in 2.803 HRD-in -67.32, -56.9 82.13, -9.82 in-out-out SNCioo out-out ActLoopNT-out 11.925 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.57 APE8-dihe-in -85.42, 67.52 APE8-rot-na 30.81 APE67-dihe-in -67.68, -8.19 -56.08, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.51 None None None XRAY 1.925 0.193 0.218 D 282 262 12 0 0 12 [[422, 678]] 1.0 6yr9 TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVSB 415 686 1052.0 PVT:701 Type1 Inactive DFGin 6.571 16.04 None -126.79, -3.83 -122.97, 123.34 -125.84, 999.0 281.41, 69.18 999.0, 999.0 in-in in 7.981 Saltbr-in 2.894 HRD-in -66.74, -51.12 77.94, -4.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.44 APE8-dihe-in -83.24, 64.15 APE8-rot-na 28.78 APE67-dihe-in -64.0, -16.76 -48.41, -44.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.19 None None None XRAY 1.81 0.193 0.215 B 282 254 18 0 0 18 [[422, 678]] 1.0 6yvs TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVSD 412 686 1052.0 PVT:701 Type1 Inactive DFGin 7.132 16.183 None -76.03, -175.56 -60.31, 138.69 -87.68, 999.0 305.08, 167.36 999.0, 999.0 in-in in 7.49 Saltbr-in 2.759 HRD-in -66.73, -51.22 77.37, -3.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.69 APE8-dihe-in -83.36, 63.72 APE8-rot-na 28.67 APE67-dihe-in -66.21, -12.54 -49.68, -44.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.298 None None None XRAY 1.81 0.193 0.215 D 282 257 18 0 0 18 [[422, 678]] 1.0 6yvs TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVYC 411 686 1052.0 P1E:802 Type1 Inactive DFGin 6.99 16.362 None -69.66, 178.7 -62.98, 133.91 -77.95, 999.0 300.74, 174.12 999.0, 999.0 in-in in 7.526 Saltbr-in 2.733 HRD-in -68.55, -50.55 78.07, -8.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.77 APE8-dihe-in -81.84, 60.78 APE8-rot-na 33.33 APE67-dihe-in -67.16, -11.03 -46.06, -44.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.188 None None None XRAY 1.918 0.215 0.235 C 282 258 18 0 0 18 [[422, 678]] 1.0 6yvy TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVYD 415 686 1052.0 P1E:701 Type1 Inactive DFGin 7.055 14.87 None -121.81, -169.66 55.51, 105.08 -131.24, 999.0 291.45, 85.32 999.0, 999.0 in-out in 7.992 Saltbr-out 4.533 HRD-in -68.69, -50.74 77.4, -7.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 145.59 APE9-dihe-in -72.33, 140.74 APE8-dihe-in -81.37, 62.58 APE8-rot-na 30.99 APE67-dihe-in -64.82, -12.74 -48.02, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.303 None None None XRAY 1.918 0.215 0.235 D 282 255 17 0 0 17 [[422, 678]] 1.0 6yvy TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YXVA 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.78 15.896 None -74.38, 172.96 -50.5, 132.87 -70.58, -33.64 295.92, 176.86 -68.7, -41.79 in-in in 7.506 Saltbr-in 2.74 HRD-in -63.96, -44.94 72.24, 2.92 in-out-out SNCioo out-out ActLoopNT-out 11.958 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.63 APE8-dihe-in -85.47, 62.62 APE8-rot-na 31.57 APE67-dihe-in -70.39, -3.07 -47.35, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.299 None None None XRAY 2.298 0.203 0.232 A 282 261 12 0 0 12 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YXVB 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.75 15.916 None -75.08, 173.66 -51.87, 131.63 -68.87, -32.97 295.29, 177.69 -68.78, -48.08 in-in in 7.657 Saltbr-in 2.741 HRD-in -62.92, -46.64 75.37, -2.33 in-out-out SNCioo out-out ActLoopNT-out 11.978 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.82 APE8-dihe-in -86.78, 62.62 APE8-rot-na 30.42 APE67-dihe-in -70.82, -2.85 -47.09, -41.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.187 None None None XRAY 2.298 0.203 0.232 B 282 260 12 0 0 12 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YXVC 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.9 16.032 None -74.5, 172.75 -51.5, 132.3 -71.72, -29.34 296.05, 175.78 -71.46, -48.84 in-in in 7.501 Saltbr-in 2.743 HRD-in -62.86, -46.42 73.82, -1.43 in-out-out SNCioo out-out ActLoopNT-out 12.077 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -77.88, 152.47 APE9-dihe-in -135.02, 147.01 APE8-dihe-in -86.57, 63.93 APE8-rot-na 30.34 APE67-dihe-in -70.64, -1.8 -47.53, -42.32 APE12-dist-na 999.0 APE11-dist-na 16.304 APE10-dist-na 14.536 APE9-dist-out 8.235 None None None XRAY 2.298 0.203 0.232 C 282 265 8 0 0 8 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YXVD 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.547 15.91 None -69.88, 170.62 -49.04, 129.98 -64.73, -39.06 297.56, 170.69 -61.08, -44.2 in-in in 7.624 Saltbr-in 2.772 HRD-in -62.37, -45.76 74.99, -1.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.03 APE8-dihe-in -85.67, 62.63 APE8-rot-na 30.22 APE67-dihe-in -70.22, -2.35 -46.36, -42.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.323 None None None XRAY 2.298 0.203 0.232 D 282 257 15 0 0 15 [[422, 678]] 1.0 6yxv TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4EBWA 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.52 8.023 None -156.77, 167.19 -119.55, 38.35 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.232 Saltbr-in 3.021 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-out 9.391 None None None XRAY 2.65 0.186 0.273 A 304 259 17 0 0 15 [[422, 678]] 1.0 4ebw TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4KAOA 415 686 1052.0 KAO:701 Type2 Inactive DFGout 12.066 12.278 BBAminus -134.79, -162.64 -155.55, 104.45 -106.77, 12.18 324.82, 118.68 -116.51, 999.0 in-in in 7.599 Saltbr-in 2.978 HRD-in -70.26, -42.49 72.38, -8.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.11 APE8-dihe-in -88.07, 63.25 APE8-rot-na 31.2 APE67-dihe-in -68.79, -9.04 -44.98, -42.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.509 P410G None None XRAY 2.39 0.183 0.216 A 282 252 20 0 0 17 [[422, 678]] 1.0 4kao TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4KAOB 414 686 1052.0 KAO:701 Type2 Inactive DFGout 12.124 11.277 BBAminus -133.46, -165.55 -153.36, 103.98 -106.18, 16.19 323.24, 119.54 -120.71, 999.0 in-out in 7.429 Saltbr-out 3.735 HRD-in -70.44, -42.65 72.16, -8.69 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.77 APE8-dihe-in -89.23, 64.34 APE8-rot-na 31.44 APE67-dihe-in -70.06, -9.42 -44.78, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.281 P410G None None XRAY 2.39 0.183 0.216 B 282 254 19 0 0 17 [[422, 678]] 1.0 4kao TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4EBVA 411 686 1052.0 0O7:60700 Type1 Inactive DFGout 11.175 7.51 None -148.69, 172.25 -125.22, 28.16 -145.3, 162.48 59.08, 99.54 -99.68, 159.32 in-in in 7.379 Saltbr-in 2.766 HRD-out -69.43, 120.16 -87.06, -29.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 152.82 APE9-dihe-in -71.94, 140.54 APE8-dihe-in -84.59, 69.22 APE8-rot-na 32.8 APE67-dihe-in -63.36, -17.19 -49.83, -44.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.246 APE9-dist-out 8.976 None None None XRAY 1.67 0.19 0.236 A 304 261 15 0 0 15 [[422, 678]] 1.0 4ebv TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4K9YA 415 685 1052.0 K9Y:701 Type2 Inactive DFGout 11.689 11.327 None -136.41, -157.16 -158.41, 138.01 -138.83, 152.71 305.51, 94.43 129.5, 144.14 in-in in 7.426 Saltbr-in 2.717 HRD-in -74.16, -44.03 80.75, -11.87 in-out-out SNCioo out-out ActLoopNT-out 11.712 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.89, 17.11 APE9-dihe-in -58.83, 133.83 APE8-dihe-in -80.92, 57.36 APE8-rot-na 33.68 APE67-dihe-in -69.17, -13.81 -45.78, -40.4 APE12-dist-na 9.884 APE11-dist-na 13.533 APE10-dist-na 9.909 APE9-dist-out 9.064 None None None XRAY 2.0 0.165 0.189 A 279 271 0 0 0 0 [[422, 678]] 1.0 4k9y TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4I4FA 415 686 1052.0 1BR:702 Type3 Inactive DFGout 13.674 8.178 None -137.25, -178.53 -131.85, 30.21 -146.33, 163.88 55.94, 90.52 -101.82, 157.06 out-out out 10.618 Saltbr-out 6.191 HRD-out -98.84, 110.46 -92.47, -29.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 158.93 APE9-dihe-in -71.56, 140.23 APE8-dihe-in -82.88, 69.99 APE8-rot-na 31.14 APE67-dihe-in -67.42, -12.73 -49.69, -43.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.614 APE9-dist-out 8.777 None None None XRAY 1.75 0.188 0.228 A 281 255 17 0 0 14 [[422, 678]] 1.0 4i4f TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
1MP8A 414 686 1052.0 ADP:800 ATPlike Inactive None 999.0 999.0 None -89.07, -172.44 90.39, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.446 Saltbr-in 3.097 HRD-in -74.41, -44.19 70.37, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.38 APE8-dihe-in -79.05, 61.98 APE8-rot-na 29.35 APE67-dihe-in -62.59, -13.79 -46.47, -46.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.07 None None None XRAY 1.6 0.188 0.23 A 281 252 21 0 0 19 [[422, 678]] 1.0 1mp8 TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
4Q9SA 414 686 1052.0 30G:701 Type1 Inactive None 999.0 999.0 None -108.96, -162.28 105.66, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.119 Saltbr-in 3.587 HRD-in -69.46, -51.39 76.26, -10.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.19 APE8-dihe-in -85.37, 63.73 APE8-rot-na 29.34 APE67-dihe-in -65.56, -17.14 -46.98, -40.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.572 None None None XRAY 2.07 0.216 0.216 A 281 252 21 0 0 19 [[422, 678]] 1.0 4q9s TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
6YVSC 414 686 1052.0 PVT:701 Type1 Inactive None 999.0 999.0 None -89.33, -115.17 -25.15, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 7.598 Saltbr-out 3.897 HRD-in -66.68, -50.09 76.47, -4.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.62 APE8-dihe-in -83.55, 64.26 APE8-rot-na 28.32 APE67-dihe-in -65.5, -13.99 -48.94, -44.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.22 None None None XRAY 1.81 0.193 0.215 C 282 254 19 0 0 19 [[422, 678]] 1.0 6yvs TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1

TYR_PTK2 (Focal adhesion kinase 1)

Total number of chains: 87
Active chains: 4
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 50 57.5% 4GU6A
DFGin ABAminus 14 16.1% 6YVYA
DFGin BLAminus 13 14.9% AF-Q05397-K1A
DFGout None 3 3.4% 4K9YA
None None 3 3.4% 6YVSC
DFGout BBAminus 2 2.3% 4KAOB
DFGin BLBminus 1 1.1% 2IJMB
DFGinter None 1 1.1% 4EBWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FAK1_CHICK 6TY4A Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.951 BLAminus -124.05, -151.88 51.86, 82.13 -107.99, 32.9 286.39, 85.0 -72.01, -36.58 in-in in 8.437 Saltbr-in 3.562 HRD-in -70.16, -30.0 74.19, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.31, 66.54 APE9-dihe-in -63.31, 139.75 APE8-dihe-in -64.41, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.19, -42.03 -70.19, -41.73 APE12-dist-na 11.489 APE11-dist-na 10.184 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 A 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6TY4B Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.95 BLAminus -124.03, -151.9 51.82, 82.14 -107.99, 32.89 286.33, 85.06 -71.97, -36.56 in-in in 8.436 Saltbr-in 3.562 HRD-in -70.15, -30.0 74.26, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.3, 66.56 APE9-dihe-in -63.34, 139.79 APE8-dihe-in -64.42, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.21, -42.01 -70.19, -41.71 APE12-dist-na 11.489 APE11-dist-na 10.183 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 B 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4VA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 6.123 15.291 ABAminus -122.16, -1.29 -156.99, 122.18 -126.9, 31.66 293.34, 65.98 -81.63, 999.0 in-in in 7.996 Saltbr-in 3.083 HRD-in -77.87, -48.56 83.88, -10.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -77.09 APE9-dihe-in -94.72, 136.23 APE8-dihe-in -75.22, 70.94 APE8-rot-na 27.07 APE67-dihe-in -66.52, -13.67 -58.3, -42.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.275 None None None XRAY 2.1 0.194 0.227 A 276 256 16 0 0 16 [[422, 678]] 1.0 4d4v Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4YB Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 4.973 14.875 ABAminus -115.15, -9.04 -143.75, 141.85 -120.63, 30.55 291.39, 86.7 127.93, -31.58 in-out in 7.743 Saltbr-out 5.056 HRD-in -80.84, -45.71 75.75, -7.5 out-out-none SNCoon out-none ActLoopNT-out 13.423 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.74 APE8-dihe-in -83.87, 62.32 APE8-rot-na 37.29 APE67-dihe-in -68.22, -16.82 -56.29, -37.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.947 None None None XRAY 1.8 0.189 0.227 B 276 260 12 0 0 12 [[422, 678]] 1.0 4d4y Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5HB Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.01 14.915 ABAminus -118.07, -3.03 -146.77, 140.81 -121.95, 32.65 292.91, 91.31 127.85, -27.62 in-out in 7.803 Saltbr-out 4.855 HRD-in -83.42, -46.05 77.42, -4.17 out-out-none SNCoon out-none ActLoopNT-out 13.409 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.03 APE8-dihe-in -83.38, 65.56 APE8-rot-na 33.73 APE67-dihe-in -67.49, -15.11 -52.74, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.842 None None None XRAY 1.75 0.183 0.205 B 276 260 12 0 0 12 [[422, 678]] 1.0 4d5h Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5KB Q00944 414 686 1053.0 No_ligand No_ligand Inactive DFGin 5.36 14.849 ABAminus -119.1, -4.63 -144.03, 135.87 -122.31, 26.55 292.91, 81.98 158.26, 999.0 in-out in 7.796 Saltbr-out 4.851 HRD-in -79.88, -47.37 77.23, -5.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -10.29 APE8-dihe-in -82.63, 60.08 APE8-rot-na 35.57 APE67-dihe-in -68.96, -15.52 -58.72, -35.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.605 None None None XRAY 1.75 0.19 0.214 B 276 256 17 0 0 17 [[422, 678]] 1.0 4d5k Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4SB Q00944 415 686 1053.0 BI9:1690 Type1 Inactive DFGin 5.45 14.621 ABAminus -111.11, -16.99 -125.52, 154.32 -137.31, 52.23 289.14, 82.0 97.11, -19.33 in-out in 7.76 Saltbr-out 4.556 HRD-in -75.76, -49.0 80.94, -1.24 out-out-none SNCoon out-none ActLoopNT-out 13.101 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.21 APE8-dihe-in -84.28, 68.41 APE8-rot-na 35.3 APE67-dihe-in -65.5, -16.9 -56.56, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.965 None None None XRAY 2.0 0.207 0.225 B 276 260 12 0 0 12 [[422, 678]] 1.0 4d4s Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4VB Q00944 415 686 1053.0 KB8:1691 Type1 Inactive DFGin 5.85 15.047 ABAminus -117.73, -0.74 -150.12, 135.85 -127.11, 29.12 290.68, 71.34 130.97, 999.0 in-out in 7.955 Saltbr-out 3.76 HRD-in -79.54, -48.18 78.6, -9.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.73 APE8-dihe-in -85.06, 62.84 APE8-rot-na 36.16 APE67-dihe-in -65.92, -16.26 -53.87, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.119 None None None XRAY 2.1 0.194 0.227 B 276 255 17 0 0 17 [[422, 678]] 1.0 4d4v Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D58B Q00944 414 686 1053.0 BI9:1690 Type1 Inactive DFGin 5.343 14.773 ABAminus -111.98, -14.84 -133.5, 141.08 -122.5, 41.04 291.15, 84.59 117.31, -28.78 in-out in 7.706 Saltbr-out 4.368 HRD-in -80.65, -46.47 80.81, -10.05 out-out-out SNCooo out-out ActLoopNT-out 13.028 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.24 APE8-dihe-in -85.92, 64.4 APE8-rot-na 36.67 APE67-dihe-in -68.12, -12.82 -55.14, -41.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.205 None None None XRAY 1.95 0.197 0.228 B 276 261 12 0 0 12 [[422, 678]] 1.0 4d58 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0LA Q00944 411 686 1053.0 ANP:1689 ATPlike Inactive DFGin 7.042 15.595 BLAminus -124.12, -151.88 51.86, 82.15 -108.03, 32.91 286.36, 85.03 -71.96, -36.63 in-in in 7.824 Saltbr-in 2.777 HRD-in -78.92, -53.9 78.76, -8.92 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.98, 100.38 APE9-dihe-in -65.3, 130.79 APE8-dihe-in -75.31, 71.06 APE8-rot-na 28.66 APE67-dihe-in -69.29, -16.82 -49.9, -41.21 APE12-dist-na 11.387 APE11-dist-na 10.256 APE10-dist-na 13.533 APE9-dist-out 8.279 None PTR576,PTR577 PTR576,PTR577 XRAY 2.3 0.217 0.263 A 276 276 0 0 0 0 [[422, 678]] 1.0 2j0l Gallus gallus TYR_PTK2_CHICK TYR 2.6e-93 318.0 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4RA Q00944 414 685 1053.0 No_ligand No_ligand Inactive DFGin 6.753 16.315 None -128.64, 175.12 33.48, 60.17 -127.21, 999.0 60.14, 81.77 999.0, 999.0 in-out in 7.554 Saltbr-out 4.275 HRD-in -77.09, -46.72 78.72, -6.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.07 APE8-dihe-in -82.55, 72.75 APE8-rot-na 32.3 APE67-dihe-in -68.58, -11.96 -57.72, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.677 None None None XRAY 1.55 0.202 0.221 A 276 251 21 0 0 18 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4RB Q00944 412 684 1053.0 No_ligand No_ligand Inactive DFGin 7.023 17.736 None -78.09, 178.28 -54.92, 128.48 -75.07, -16.05 303.31, 165.11 -65.19, -11.08 out-out out 10.231 Saltbr-out 10.2 HRD-in -77.54, -48.96 77.86, -1.75 out-out-none SNCoon out-none ActLoopNT-out 10.051 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.59 APE8-dihe-in -81.78, 61.99 APE8-rot-na 34.83 APE67-dihe-in -67.78, -12.73 -54.67, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.78 None None None XRAY 1.55 0.202 0.221 B 276 270 3 0 0 3 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4SA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.335 14.49 None -114.18, -4.67 -150.83, 135.97 -129.43, 999.0 291.59, 99.53 999.0, 999.0 in-in in 7.87 Saltbr-in 2.988 HRD-in -76.62, -49.37 85.0, -10.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 143.71 APE9-dihe-in -71.69, 139.37 APE8-dihe-in -80.22, 72.42 APE8-rot-na 32.17 APE67-dihe-in -66.95, -17.13 -56.96, -41.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.103 None None None XRAY 2.0 0.207 0.225 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d4s Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4YA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.018 14.514 None -118.29, -10.26 -147.25, 131.73 -119.37, 999.0 297.41, 102.39 999.0, 999.0 in-in in 7.798 Saltbr-in 2.444 HRD-in -81.89, -51.68 81.97, -7.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -42.9 APE9-dihe-in -67.29, 140.52 APE8-dihe-in -79.28, 66.93 APE8-rot-na 16.31 APE67-dihe-in -68.8, -8.86 -56.17, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.251 None None None XRAY 1.8 0.189 0.227 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d4y Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D58A Q00944 414 686 1053.0 No_ligand No_ligand Inactive DFGin 5.448 14.95 None -119.32, -6.79 -143.39, 120.13 -112.99, 999.0 292.94, 94.83 999.0, 999.0 in-in in 8.204 Saltbr-in 2.717 HRD-in -82.22, -48.88 82.65, -10.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.86 APE8-dihe-in -79.5, 65.59 APE8-rot-na 31.69 APE67-dihe-in -68.56, -13.14 -56.02, -40.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 None None None XRAY 1.95 0.197 0.228 A 276 255 18 0 0 18 [[422, 678]] 1.0 4d58 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5KA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.582 15.122 None -117.73, -5.95 -151.01, 133.04 -124.81, 999.0 284.01, 85.38 999.0, 999.0 in-in in 7.888 Saltbr-in 3.584 HRD-in -86.7, -47.97 80.45, -6.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -43.63 APE9-dihe-in -60.17, 136.23 APE8-dihe-in -79.08, 66.16 APE8-rot-na 27.0 APE67-dihe-in -72.5, -9.93 -52.21, -39.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.233 None None None XRAY 1.75 0.19 0.214 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d5k Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6TY3A Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.567 14.452 None -135.16, 170.63 86.31, -91.36 58.85, 65.75 299.77, 89.22 -131.55, 157.07 in-out in 8.259 Saltbr-out 3.768 HRD-in -98.85, -42.65 73.64, -10.05 out-out-out SNCooo out-out ActLoopNT-out 12.361 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.38, 179.3 APE9-dihe-in -128.41, 160.02 APE8-dihe-in -77.79, 72.21 APE8-rot-na 27.16 APE67-dihe-in -64.5, -27.16 -60.23, -43.57 APE12-dist-na 14.964 APE11-dist-na 15.593 APE10-dist-na 17.373 APE9-dist-out 8.629 None None None EM 6.32 999.0 999.0 A 658 600 10 0 0 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6TY3B Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.567 14.451 None -135.19, 170.62 86.26, -91.32 58.84, 65.75 299.77, 89.17 -131.52, 157.04 in-out in 8.259 Saltbr-out 3.767 HRD-in -98.85, -42.61 73.64, -10.1 out-out-out SNCooo out-out ActLoopNT-out 12.36 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.36, 179.28 APE9-dihe-in -128.39, 160.01 APE8-dihe-in -77.75, 72.19 APE8-rot-na 27.19 APE67-dihe-in -64.56, -27.16 -60.28, -43.5 APE12-dist-na 14.965 APE11-dist-na 15.594 APE10-dist-na 17.373 APE9-dist-out 8.63 None None None EM 6.32 999.0 999.0 B 658 600 10 0 0 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKMA Q00944 413 686 1053.0 BII:1687 Type1 Inactive DFGin 6.979 15.597 None -114.99, -166.2 1.63, 119.82 87.35, -47.95 314.75, 124.67 -93.91, 178.82 in-in in 7.425 Saltbr-in 2.805 HRD-in -72.67, -52.48 88.19, -13.59 in-out-out SNCioo out-out ActLoopNT-out 14.999 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.01 APE8-dihe-in -71.46, 57.0 APE8-rot-na 27.37 APE67-dihe-in -75.95, 0.41 -40.68, -47.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 None None None XRAY 2.31 0.211 0.272 A 276 260 14 0 0 14 [[422, 678]] 1.0 2jkm Gallus gallus TYR_PTK2_CHICK TYR 1.4e-93 318.9 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0MB Q00944 414 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.972 14.287 None -122.76, 167.67 145.4, -137.08 -124.29, 100.35 290.36, 64.77 -132.69, 154.11 in-in in 7.468 Saltbr-in 2.443 HRD-in -71.25, -49.34 81.19, -3.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.23 APE8-dihe-in -85.72, 66.92 APE8-rot-na 31.09 APE67-dihe-in -64.84, -11.69 -52.92, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.379 None None None XRAY 2.8 0.224 0.282 B 276 257 16 0 0 16 [[422, 678]] 1.0 2j0m Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKQA Q00944 414 686 1053.0 VG8:1687 Type1 Inactive DFGin 6.434 15.77 None -75.88, 179.74 -51.42, 124.37 -59.35, -36.75 304.41, 5.5 -52.05, -42.43 in-in in 7.494 Saltbr-in 2.623 HRD-in -66.06, -52.83 77.77, -12.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.31 APE8-dihe-in -81.47, 65.67 APE8-rot-na 31.77 APE67-dihe-in -69.2, -7.68 -48.0, -45.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.883 None None None XRAY 2.6 0.217 0.262 A 276 258 15 0 0 15 [[422, 678]] 1.0 2jkq Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKKA Q00944 413 684 1053.0 BI9:1686 Type1 Inactive DFGin 6.662 15.946 None -75.15, -171.72 -62.78, 135.39 -69.82, -36.92 292.96, 7.69 -58.64, -47.49 in-in in 7.466 Saltbr-in 2.795 HRD-in -67.23, -54.57 79.75, -14.16 in-out-none SNCion out-none ActLoopNT-out 10.52 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.56 APE8-dihe-in -81.25, 65.87 APE8-rot-na 28.94 APE67-dihe-in -64.8, -17.36 -41.67, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.961 None None None XRAY 2.0 0.182 0.236 A 276 258 14 0 0 14 [[422, 678]] 1.0 2jkk Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKOA Q00944 415 686 1053.0 BIJ:1687 Type1 Inactive DFGin 6.824 16.288 None -76.65, 177.09 -51.97, 132.66 -73.02, -22.84 294.23, 6.85 -74.57, -42.86 in-in in 8.264 Saltbr-in 3.576 HRD-in -81.96, -48.92 77.27, -4.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.22 APE8-dihe-in -78.31, 62.64 APE8-rot-na 29.54 APE67-dihe-in -67.04, -13.81 -48.71, -43.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.932 None None None XRAY 1.65 0.19 0.217 A 276 256 16 0 0 16 [[422, 678]] 1.0 2jko Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4BRXA Q00944 413 684 1053.0 KGW:1685 Type1 Inactive DFGin 6.567 15.804 None -85.04, -171.69 -52.6, 140.21 -75.53, -32.77 290.76, 3.08 -64.53, -44.35 in-in in 7.276 Saltbr-in 2.817 HRD-in -72.91, -56.18 75.54, -1.8 in-out-out SNCioo out-out ActLoopNT-out 10.429 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.09 APE8-dihe-in -77.77, 68.02 APE8-rot-na 18.27 APE67-dihe-in -64.57, -19.31 -48.57, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.203 None None None XRAY 2.05 0.199 0.239 A 276 260 12 0 0 12 [[422, 678]] 1.0 4brx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4C7TA Q00944 414 684 1053.0 5RI:1685 Type1 Inactive DFGin 6.533 15.84 None -77.4, -179.92 -52.87, 136.35 -71.95, -38.06 294.7, 1.19 -59.39, -44.61 in-in in 7.517 Saltbr-in 2.969 HRD-in -72.59, -59.08 84.11, -4.81 in-out-none SNCion out-none ActLoopNT-out 10.431 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.59 APE8-dihe-in -78.35, 70.91 APE8-rot-na 26.06 APE67-dihe-in -65.2, -16.6 -50.79, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.893 None None None XRAY 2.05 0.22 0.246 A 276 259 12 0 0 12 [[422, 678]] 1.0 4c7t Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5HA Q00944 415 686 1053.0 9RM:1687 Type1 Inactive DFGin 8.789 16.179 None -119.76, -8.44 -152.2, 131.56 -67.1, 999.0 180.84, 34.18 999.0, 999.0 in-out in 7.91 Saltbr-out 3.715 HRD-in -79.33, -48.38 80.51, -4.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.09 APE9-dihe-in -60.1, 142.63 APE8-dihe-in -82.47, 68.46 APE8-rot-na 31.45 APE67-dihe-in -67.73, -13.99 -56.02, -40.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.168 None None None XRAY 1.75 0.183 0.205 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d5h Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCRA Q00944 413 684 1053.0 EUW:701 Type1 Inactive DFGin 6.738 16.103 None -70.87, -166.97 -65.32, 125.1 -57.74, -34.57 287.47, 8.46 -73.02, -37.86 in-in in 7.567 Saltbr-in 2.463 HRD-in -75.05, -55.09 81.04, -5.76 in-out-out SNCioo out-out ActLoopNT-out 10.419 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.27 APE8-dihe-in -77.73, 61.32 APE8-rot-na 29.84 APE67-dihe-in -67.52, -6.96 -49.75, -48.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.358 None None None XRAY 2.3 0.214 0.262 A 276 258 14 0 0 14 [[422, 678]] 1.0 6gcr Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCWA Q00944 414 685 1053.0 EUQ:701 Type1 Inactive DFGin 6.285 15.228 None -130.25, -162.76 64.22, 75.01 -107.3, 999.0 290.51, 75.53 999.0, 999.0 in-out in 8.033 Saltbr-out 4.377 HRD-in -81.64, -46.43 83.77, -4.99 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.84 APE8-dihe-in -78.48, 68.9 APE8-rot-na 34.42 APE67-dihe-in -73.52, -10.12 -55.06, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.395 None None None XRAY 2.0 0.22 0.274 A 276 254 18 0 0 18 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCWB Q00944 414 686 1053.0 EUQ:701 Type1 Inactive DFGin 6.539 15.837 None -81.1, -172.36 -60.09, 131.66 -68.99, -32.35 293.15, 10.83 -65.72, -42.14 in-in in 7.573 Saltbr-in 2.679 HRD-in -76.57, -51.51 74.74, 1.93 in-out-out SNCioo out-out ActLoopNT-out 11.07 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.67 APE8-dihe-in -80.93, 60.16 APE8-rot-na 31.79 APE67-dihe-in -70.89, -7.66 -53.84, -42.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.822 None None None XRAY 2.0 0.22 0.274 B 276 259 14 0 0 14 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCXA Q00944 413 686 1053.0 EUW:701 Type1 Inactive DFGin 6.779 16.445 None -72.0, 177.39 -57.13, 134.48 -70.38, -29.96 294.86, 177.92 -65.58, -46.38 in-in in 8.091 Saltbr-in 3.047 HRD-in -82.56, -49.93 78.9, -6.95 in-out-out SNCioo out-out ActLoopNT-out 10.846 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.29 APE8-dihe-in -79.72, 63.89 APE8-rot-na 33.8 APE67-dihe-in -69.74, -9.01 -53.44, -42.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.009 None None None XRAY 1.553 0.186 0.219 A 276 258 16 0 0 14 [[422, 678]] 1.0 6gcx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0JA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.918 14.385 None -123.19, 169.5 101.29, -103.63 66.49, 28.41 317.16, 97.31 -90.27, 177.52 in-in in 8.119 Saltbr-in 2.703 HRD-in -78.32, -40.43 79.32, -8.22 in-out-out SNCioo out-out ActLoopNT-out 12.463 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.84 APE8-dihe-in -80.69, 57.63 APE8-rot-na 26.07 APE67-dihe-in -61.42, -10.9 -40.75, -50.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.849 None None None XRAY 2.8 0.22 0.274 A 656 611 10 0 0 10 [[422, 678]] 1.0 2j0j Gallus gallus TYR_PTK2_CHICK TYR 3.1e-92 314.9 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0KA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.84 14.522 None -94.55, -93.91 -78.14, -58.62 58.67, 36.74 310.17, 120.14 -115.82, 158.23 in-in in 8.167 Saltbr-in 2.834 HRD-in -98.8, -33.31 77.39, -21.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 52.29 APE9-dihe-in -82.72, 133.73 APE8-dihe-in -69.87, 64.39 APE8-rot-na 25.61 APE67-dihe-in -58.59, -19.95 -50.1, -51.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.019 APE9-dist-out 8.81 None None None XRAY 3.0 0.237 0.299 A 656 598 15 0 0 15 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0KB Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.8 13.944 None -96.91, -85.38 -80.15, -63.34 50.19, 5.1 328.51, 122.72 -57.61, 145.44 in-in in 8.042 Saltbr-in 3.114 HRD-in -78.83, -42.91 75.23, -10.09 in-out-out SNCioo out-out ActLoopNT-out 10.513 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -80.14, 57.93 APE8-rot-na 30.91 APE67-dihe-in -67.94, -7.65 -42.39, -46.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.247 None None None XRAY 3.0 0.237 0.299 B 656 612 14 0 0 14 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D55A Q00944 413 685 1053.0 No_ligand No_ligand None DFGin 6.834 15.362 BLAminus -129.2, -159.95 50.2, 79.76 -106.48, 46.83 298.83, 47.66 -60.24, -40.26 in-in in 7.559 Saltbr-in 3.312 HRD-in -79.77, -47.22 74.9, 2.93 in-in-none SNCiin in-none ActLoopNT-in 3.111 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.67 APE8-dihe-in -81.31, 64.05 APE8-rot-na 32.07 APE67-dihe-in -63.23, -12.78 -45.98, -50.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.641 None None None XRAY 2.3 0.201 0.257 A 276 260 13 0 0 13 [[422, 678]] 1.0 4d55 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN AF-Q05397-K1A Q05397 414 686 1052.0 No_ligand No_ligand Active DFGin 6.28 14.616 BLAminus -130.37, -169.73 56.83, 67.25 -84.76, 10.0 286.01, 85.02 -60.3, -29.65 in-in in 7.772 Saltbr-in 2.659 HRD-in -80.45, -42.93 64.64, -5.62 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -68.41, 131.91 APE9-dihe-in -132.13, 129.29 APE8-dihe-in -80.18, 69.23 APE8-rot-na 34.6 APE67-dihe-in -69.07, -14.62 -44.93, -40.49 APE12-dist-na 13.969 APE11-dist-na 10.284 APE10-dist-na 10.381 APE9-dist-in 7.024 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[422, 678]] 1.0 AF-Q05397-K1 Homo sapiens TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN AF-Q05397-K3A Q05397 414 686 1052.0 No_ligand No_ligand Active DFGin 5.937 14.109 BLAminus -132.43, -167.86 50.51, 75.71 -84.77, 10.13 293.07, 91.02 -61.11, -27.99 in-in in 8.107 Saltbr-in 2.703 HRD-in -79.74, -43.96 66.37, 0.29 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.22, 136.4 APE9-dihe-in -136.53, 152.75 APE8-dihe-in -80.89, 62.21 APE8-rot-na 36.87 APE67-dihe-in -68.15, -14.35 -42.6, -41.72 APE12-dist-na 14.027 APE11-dist-na 10.645 APE10-dist-na 10.954 APE9-dist-in 6.74 None None None AF2 -1.0 1.0 1.0 A 273 273 0 0 0 0 [[422, 678]] 1.0 AF-Q05397-K3 Homo sapiens TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 9SDIA Q05397 414 686 1052.0 A1JNJ:705 Type1 Inactive DFGin 3.565 13.297 ABAminus -111.82, -18.24 -124.75, 169.76 -130.67, -27.74 302.6, 98.83 -32.6, 999.0 in-out in 7.685 Saltbr-out 4.447 HRD-in -90.69, -45.97 77.93, -2.68 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 144.05 APE8-dihe-in -93.73, 62.5 APE8-rot-na 18.7 APE67-dihe-in -65.12, -21.79 -51.01, -41.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.423 None None None XRAY 2.53 0.184 0.241 A 277 256 17 0 0 17 [[422, 678]] 1.0 9sdi Homo sapiens TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 3PXKA Q05397 415 687 1052.0 PXK:701 Type1 Inactive DFGin 6.144 15.31 ABAminus -120.11, -2.63 -137.28, 131.22 -129.5, 22.87 289.37, 86.78 -73.41, 999.0 in-in in 8.065 Saltbr-in 2.707 HRD-in -73.28, -47.59 77.2, -9.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 143.04 APE8-dihe-in -81.54, 63.47 APE8-rot-na 31.8 APE67-dihe-in -69.25, -13.88 -43.54, -40.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.732 P410G None None XRAY 1.79 0.185 0.216 A 282 256 17 0 0 17 [[422, 678]] 1.0 3pxk Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 3PXKB Q05397 414 687 1052.0 PXK:702 Type1 Inactive DFGin 6.059 14.414 ABAminus -117.18, -5.52 -138.67, 135.85 -133.31, 18.42 288.86, 88.66 -64.83, -34.02 in-in in 7.797 Saltbr-in 2.662 HRD-in -73.1, -47.41 72.71, -3.69 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.84 APE8-dihe-in -82.41, 66.29 APE8-rot-na 24.52 APE67-dihe-in -65.63, -9.44 -49.9, -47.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.785 P410G None None XRAY 1.79 0.185 0.216 B 282 258 16 0 0 16 [[422, 678]] 1.0 3pxk Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YT6A Q05397 414 686 1052.0 PKE:701 Type1 Inactive DFGin 6.167 15.301 ABAminus -125.68, 11.47 -143.86, 126.64 -128.72, 27.06 294.54, 78.63 -86.25, -18.25 in-in in 7.949 Saltbr-in 2.705 HRD-in -77.73, -46.86 79.23, -10.83 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.13 APE8-dihe-in -80.24, 58.16 APE8-rot-na 31.27 APE67-dihe-in -67.36, -9.68 -46.75, -46.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.799 None None None XRAY 1.537 0.191 0.212 A 282 256 17 0 0 15 [[422, 678]] 1.0 6yt6 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YT6B Q05397 414 686 1052.0 PKE:701 Type1 Inactive DFGin 6.176 14.965 ABAminus -123.82, 10.73 -142.81, 128.01 -131.84, 29.41 294.35, 82.53 -81.12, 159.2 in-in in 7.619 Saltbr-in 2.716 HRD-in -78.8, -45.97 74.91, -5.57 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 118.15 APE9-dihe-in -105.54, 143.24 APE8-dihe-in -81.67, 62.69 APE8-rot-na 30.59 APE67-dihe-in -67.33, -11.15 -47.56, -44.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.695 APE9-dist-in 7.832 None None None XRAY 1.537 0.191 0.212 B 282 258 15 0 0 15 [[422, 678]] 1.0 6yt6 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVSA Q05397 414 686 1052.0 PVT:701 Type1 Inactive DFGin 7.037 16.11 ABAminus -123.36, 1.14 -129.41, 122.1 -120.04, 23.57 289.1, 75.16 -54.09, -36.16 in-out in 8.801 Saltbr-out 4.042 HRD-in -69.73, -49.55 71.97, 3.79 out-in-none SNCoin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 152.96 APE9-dihe-in -82.83, 138.18 APE8-dihe-in -84.21, 64.83 APE8-rot-na 34.21 APE67-dihe-in -64.52, -14.48 -50.82, -42.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.46 APE9-dist-in 7.91 None None None XRAY 1.81 0.193 0.215 A 282 260 13 0 0 13 [[422, 678]] 1.0 6yvs Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVYA Q05397 412 686 1052.0 P1E:701 Type1 Inactive DFGin 6.923 16.058 ABAminus -123.33, 0.59 -123.32, 123.05 -122.83, 25.97 286.06, 70.66 -56.13, -41.38 in-out in 8.868 Saltbr-out 4.165 HRD-in -73.46, -49.62 72.4, 1.81 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.5, 136.03 APE9-dihe-in -79.34, 137.37 APE8-dihe-in -82.93, 65.49 APE8-rot-na 31.34 APE67-dihe-in -64.99, -13.14 -47.78, -44.49 APE12-dist-na 999.0 APE11-dist-na 9.419 APE10-dist-na 11.972 APE9-dist-in 7.612 None None None XRAY 1.918 0.215 0.235 A 282 265 10 0 0 10 [[422, 678]] 1.0 6yvy Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4GU9B Q05397 415 683 1052.0 4GU:701 Type1 Inactive DFGin 6.61 16.037 BLAminus -125.5, -158.26 48.51, 68.16 -94.75, 10.99 282.95, 68.33 -94.28, -13.76 in-in in 7.913 Saltbr-in 3.357 HRD-in -71.95, -46.82 78.11, -13.81 in-out-out SNCioo out-out ActLoopNT-out 12.74 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.17 APE8-dihe-in -81.64, 64.78 APE8-rot-na 30.94 APE67-dihe-in -68.87, -11.47 -50.39, -42.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.984 None None None XRAY 2.4 0.18 0.221 B 279 255 14 0 0 12 [[422, 678]] 1.0 4gu9 Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4K8AA Q05397 414 683 1052.0 K8A:701 Type1 Inactive DFGin 6.983 15.401 BLAminus -121.47, -166.12 54.91, 76.43 -107.93, 50.57 283.28, 87.55 -142.37, 999.0 in-out in 7.721 Saltbr-out 3.639 HRD-in -64.7, -43.35 74.08, -12.6 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.33 APE8-dihe-in -76.77, 64.66 APE8-rot-na 29.01 APE67-dihe-in -72.21, -11.17 -51.86, -41.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.826 None None None XRAY 2.91 0.184 0.224 A 279 251 19 0 0 17 [[422, 678]] 1.0 4k8a Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4K8AB Q05397 414 684 1052.0 K8A:701 Type1 Inactive DFGin 6.914 15.705 BLAminus -115.4, -153.96 47.26, 77.74 -107.18, 24.9 279.88, 84.24 -112.96, -15.47 in-out in 7.762 Saltbr-out 3.8 HRD-in -64.66, -47.31 78.56, -14.07 out-out-out SNCooo out-out ActLoopNT-out 12.804 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.66 APE8-dihe-in -75.55, 65.45 APE8-rot-na 29.5 APE67-dihe-in -69.34, -11.69 -52.26, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.054 None None None XRAY 2.91 0.184 0.224 B 279 258 13 0 0 13 [[422, 678]] 1.0 4k8a Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4KABB Q05397 414 684 1052.0 4KA:701 Type1 Inactive DFGin 6.57 15.738 BLAminus -121.46, -160.12 49.21, 75.34 -97.29, 8.37 281.34, 75.31 -102.38, -7.12 in-in in 7.717 Saltbr-in 3.033 HRD-in -73.34, -42.86 75.98, -10.51 in-out-out SNCioo out-out ActLoopNT-out 12.701 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.03 APE8-dihe-in -79.93, 66.69 APE8-rot-na 28.5 APE67-dihe-in -72.71, -9.14 -55.44, -38.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.823 None None None XRAY 2.71 0.173 0.219 B 279 258 13 0 0 12 [[422, 678]] 1.0 4kab Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 2ETMA Q05397 415 686 1052.0 7PY:131 Type1 Inactive DFGin 6.194 15.906 BLAminus -139.03, -155.38 54.99, 56.46 -78.64, -20.58 280.28, 75.46 -75.88, -7.09 in-out in 7.691 Saltbr-out 4.019 HRD-in -68.86, -57.97 98.34, -20.82 out-out-out SNCooo out-out ActLoopNT-out 12.707 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 126.3 APE9-dihe-in -124.3, 115.41 APE8-dihe-in -74.42, 59.49 APE8-rot-na 32.57 APE67-dihe-in -67.6, -4.02 -51.51, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.265 APE9-dist-out 9.524 None None None XRAY 2.3 0.215 0.295 A 281 262 10 0 0 10 [[422, 678]] 1.0 2etm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 2ETMB Q05397 413 689 1052.0 7PY:132 Type1 Inactive DFGin 6.508 15.636 BLAminus -131.46, -154.81 60.14, 64.69 -93.52, 10.54 284.78, 95.79 -111.33, 2.27 in-in in 7.694 Saltbr-in 2.726 HRD-in -70.42, -51.89 89.97, -15.7 in-out-out SNCioo out-out ActLoopNT-out 11.88 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.44 APE8-dihe-out -74.95, 49.29 APE8-rot-na 34.9 APE67-dihe-in -71.5, -6.36 -45.52, -37.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.375 None None None XRAY 2.3 0.215 0.295 B 281 263 14 0 0 14 [[422, 678]] 1.0 2etm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVYB Q05397 415 686 1052.0 P1E:701 Type1 Inactive DFGin 6.76 16.154 BLAminus -125.37, -159.56 46.15, 75.22 -98.8, 22.63 289.45, 61.98 -103.7, -1.46 in-in in 8.082 Saltbr-in 2.884 HRD-in -68.13, -50.71 78.23, -5.43 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.05 APE8-dihe-in -81.82, 62.53 APE8-rot-na 30.96 APE67-dihe-in -65.78, -13.58 -48.49, -45.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.28 None None None XRAY 1.918 0.215 0.235 B 282 257 15 0 0 15 [[422, 678]] 1.0 6yvy Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 2IJMB Q05397 414 689 1052.0 ADP:800 ATPlike Inactive DFGin 6.323 15.493 BLBminus -110.71, -163.98 67.21, 81.0 -117.82, 145.96 283.77, 97.43 -64.08, -51.52 in-out in 7.648 Saltbr-out 3.676 HRD-in -77.75, -52.2 82.75, -4.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -36.05 APE8-dihe-out -75.82, 46.85 APE8-rot-na 30.48 APE67-dihe-in -72.2, -5.65 -47.65, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.699 None None None XRAY 2.187 0.211 0.271 B 281 261 15 0 0 15 [[422, 678]] 1.0 2ijm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 2IJMA Q05397 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.335 15.255 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.602 Saltbr-in 2.544 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.531 None None None XRAY 2.187 0.211 0.271 A 281 260 15 0 0 15 [[422, 678]] 1.0 2ijm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 7PI4DDD Q05397 415 687 1052.0 No_ligand No_ligand Inactive DFGin 6.642 15.76 None -89.21, -168.8 -53.97, 129.66 -63.34, -43.26 292.53, 5.46 -58.42, -48.1 in-in in 7.459 Saltbr-in 2.722 HRD-in -72.06, -49.67 76.25, -8.72 in-out-out SNCioo out-out ActLoopNT-out 10.484 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.81 APE9-dihe-in -72.54, 128.52 APE8-dihe-in -81.98, 69.32 APE8-rot-na 34.58 APE67-dihe-in -74.94, -9.99 -55.31, -40.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.095 APE9-dist-out 8.638 None None None XRAY 2.24 0.198 0.251 DDD 273 264 9 0 0 9 [[422, 678]] 1.0 7pi4 Homo sapiens TYR_PTK2_HUMAN TYR 3.1e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 9SDIB Q05397 414 685 1052.0 No_ligand No_ligand Inactive DFGin 4.005 13.17 None -97.64, -137.83 -54.67, 146.24 -100.48, 130.01 327.08, 92.25 63.05, 999.0 in-out in 8.106 Saltbr-out 8.294 HRD-in -82.43, -51.16 74.28, 13.4 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.88 APE8-dihe-in -70.36, 61.66 APE8-rot-na 27.15 APE67-dihe-in -67.38, -13.24 -53.44, -40.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.978 None None None XRAY 2.53 0.184 0.241 B 277 255 17 0 0 17 [[422, 678]] 1.0 9sdi Homo sapiens TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 3BZ3A Q05397 414 689 1052.0 YAM:1 Type1 Inactive DFGin 6.672 15.85 None -79.02, -179.99 -56.66, 136.15 -73.84, -38.07 287.89, 7.91 -61.02, -47.25 in-in in 7.527 Saltbr-in 2.589 HRD-in -85.54, -56.7 90.17, -10.54 in-out-out SNCioo out-out ActLoopNT-out 10.556 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.15 APE8-dihe-in -80.58, 72.72 APE8-rot-na 30.9 APE67-dihe-in -70.02, -11.94 -54.79, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 None None None XRAY 2.2 0.16 0.234 A 276 259 17 0 0 13 [[422, 678]] 1.0 3bz3 Homo sapiens TYR_PTK2_HUMAN TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4GU9A Q05397 414 685 1052.0 4GU:701 Type1 Inactive DFGin 6.699 15.701 None -123.83, 12.04 -117.35, 108.51 -134.16, 999.0 294.29, 94.21 999.0, 999.0 in-in in 7.769 Saltbr-in 3.492 HRD-in -72.07, -46.62 76.1, -11.95 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.49 APE8-dihe-in -81.89, 65.04 APE8-rot-na 31.19 APE67-dihe-in -69.72, -10.34 -49.89, -42.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.656 None None None XRAY 2.4 0.18 0.221 A 279 252 20 0 0 18 [[422, 678]] 1.0 4gu9 Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4KABA Q05397 412 686 1052.0 4KA:701 Type1 Inactive DFGin 6.39 15.555 None -111.52, -14.16 -107.87, 122.87 -138.65, 999.0 293.6, 93.91 999.0, 999.0 in-in in 7.705 Saltbr-in 3.059 HRD-in -73.14, -43.25 75.58, -10.35 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.68 APE8-dihe-in -81.37, 68.28 APE8-rot-na 28.59 APE67-dihe-in -69.97, -11.06 -55.99, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.54 None None None XRAY 2.71 0.173 0.219 A 279 255 20 0 0 18 [[422, 678]] 1.0 4kab Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6I8ZA Q05397 414 688 1052.0 H82:701 Type1 Inactive DFGin 6.534 15.739 None -73.65, -177.37 -59.05, 135.57 -69.93, -28.35 299.91, 168.26 -68.89, -44.51 in-in in 7.601 Saltbr-in 2.804 HRD-in -70.2, -51.5 74.46, -8.27 in-out-out SNCioo out-out ActLoopNT-out 10.52 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.99 APE8-dihe-in -84.17, 66.78 APE8-rot-na 36.24 APE67-dihe-in -65.96, -15.87 -53.48, -40.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.416 None None None XRAY 1.99 0.185 0.222 A 281 261 14 0 0 14 [[422, 678]] 1.0 6i8z Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4I4EA Q05397 414 686 1052.0 1BQ:1000 Type1 Inactive DFGin 6.79 16.342 None -103.61, -97.99 -1.1, -106.34 55.03, 999.0 299.48, 75.74 999.0, 999.0 in-out in 7.698 Saltbr-out 3.748 HRD-in -79.84, -49.84 80.8, -2.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.29 APE8-dihe-in -79.67, 64.72 APE8-rot-na 33.35 APE67-dihe-in -67.06, -11.75 -53.27, -42.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.263 None None None XRAY 1.55 0.166 0.189 A 281 254 19 0 0 18 [[422, 678]] 1.0 4i4e Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4GU6A Q05397 414 686 1052.0 10N:701 Type1 Inactive DFGin 6.725 15.721 None -78.95, -178.49 -53.69, 136.88 -71.82, -34.41 298.6, 168.4 -65.26, -49.08 in-in in 7.521 Saltbr-in 2.697 HRD-in -71.62, -48.61 84.03, -17.12 in-out-out SNCioo out-out ActLoopNT-out 9.638 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -143.19, 149.54 APE9-dihe-in -51.38, 136.95 APE8-dihe-in -84.93, 56.73 APE8-rot-na 35.61 APE67-dihe-in -63.59, -13.44 -54.64, -43.26 APE12-dist-na 13.418 APE11-dist-na 11.77 APE10-dist-na 15.228 APE9-dist-out 9.376 None None None XRAY 1.95 0.171 0.194 A 282 271 2 0 0 0 [[422, 678]] 1.0 4gu6 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4GU6B Q05397 415 686 1052.0 10N:701 Type1 Inactive DFGin 6.732 15.951 None -79.45, -179.1 -51.77, 131.29 -67.64, -33.77 299.56, 166.92 -65.8, -45.35 in-in in 7.527 Saltbr-in 2.728 HRD-in -73.02, -50.64 78.02, -11.87 in-out-out SNCioo out-out ActLoopNT-out 10.862 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.41 APE8-dihe-in -75.09, 60.15 APE8-rot-na 31.47 APE67-dihe-in -63.51, -13.22 -52.64, -44.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.244 None None None XRAY 1.95 0.171 0.194 B 282 258 14 0 0 14 [[422, 678]] 1.0 4gu6 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YOJA Q05397 414 686 1052.0 P4N:701 Type1 Inactive DFGin 6.517 15.964 None -76.38, -175.19 -62.53, 137.68 -71.29, -34.87 295.0, 178.59 -63.41, -49.08 in-in in 7.419 Saltbr-in 2.765 HRD-in -74.52, -48.86 75.74, -8.06 in-out-none SNCion out-none ActLoopNT-out 10.504 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.61 APE8-dihe-in -85.09, 65.79 APE8-rot-na 30.31 APE67-dihe-in -64.59, -10.84 -48.78, -45.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.798 None None None XRAY 1.361 0.172 0.198 A 282 259 14 0 0 14 [[422, 678]] 1.0 6yoj Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YQ1A Q05397 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.772 15.904 None -76.89, 179.45 -55.75, 133.99 -70.6, -39.73 296.27, 174.79 -61.86, -42.84 in-in in 7.546 Saltbr-in 2.913 HRD-in -71.31, -56.22 78.91, -8.0 in-out-out SNCioo out-out ActLoopNT-out 12.154 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -50.8 APE9-dihe-in -136.97, 142.61 APE8-dihe-in -82.64, 66.53 APE8-rot-na 31.58 APE67-dihe-in -67.94, -11.22 -48.21, -42.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.47 APE9-dist-out 8.283 None None None XRAY 1.784 0.184 0.214 A 282 269 3 0 0 3 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YQ1B Q05397 411 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.896 16.008 None -76.83, 179.03 -54.23, 132.73 -71.29, -38.79 295.55, 174.7 -61.35, -42.29 in-in in 7.53 Saltbr-in 2.865 HRD-in -73.31, -54.59 78.37, -7.32 in-out-out SNCioo out-out ActLoopNT-out 12.023 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -48.66, 142.89 APE9-dihe-in -137.31, 146.9 APE8-dihe-in -83.8, 68.09 APE8-rot-na 31.86 APE67-dihe-in -70.2, -9.5 -48.58, -42.33 APE12-dist-na 13.399 APE11-dist-na 16.849 APE10-dist-na 14.837 APE9-dist-out 8.254 None None None XRAY 1.784 0.184 0.214 B 282 273 3 0 0 3 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YQ1C Q05397 412 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.581 15.841 None -75.66, -177.24 -55.77, 133.76 -67.84, -41.72 295.72, 176.78 -60.36, -44.8 in-in in 7.615 Saltbr-in 2.857 HRD-in -71.08, -53.73 81.02, -10.73 in-out-out SNCioo out-out ActLoopNT-out 10.633 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -15.64 APE9-dihe-in -96.3, 121.87 APE8-dihe-in -82.84, 65.74 APE8-rot-na 33.11 APE67-dihe-in -65.58, -12.51 -46.04, -44.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.989 APE9-dist-out 8.832 None None None XRAY 1.784 0.184 0.214 C 282 264 11 0 0 11 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YQ1D Q05397 415 686 1052.0 P7N:60701 Type1 Inactive DFGin 6.657 15.854 None -76.76, -177.88 -55.33, 133.74 -70.22, -39.58 296.95, 175.58 -62.46, -41.81 in-in in 7.523 Saltbr-in 2.881 HRD-in -70.74, -53.46 79.06, -11.18 in-out-out SNCioo out-out ActLoopNT-out 11.813 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.88 APE8-dihe-in -83.88, 65.98 APE8-rot-na 32.0 APE67-dihe-in -68.39, -9.16 -46.59, -43.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.43 None None None XRAY 1.784 0.184 0.214 D 282 258 14 0 0 14 [[422, 678]] 1.0 6yq1 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YR9A Q05397 415 686 1052.0 P9K:701 Type1 Inactive DFGin 6.693 15.656 None -72.52, -178.45 -57.73, 135.79 -72.85, -37.79 298.07, 168.43 -63.0, -44.27 in-in in 7.537 Saltbr-in 2.756 HRD-in -68.47, -56.13 84.19, -11.31 in-out-out SNCioo out-out ActLoopNT-out 11.971 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.92 APE8-dihe-in -80.86, 65.41 APE8-rot-na 32.51 APE67-dihe-in -65.96, -9.35 -56.05, -39.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.807 None None None XRAY 1.925 0.193 0.218 A 282 260 12 0 0 12 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YR9B Q05397 414 684 1052.0 P9K:701 Type1 Inactive DFGin 6.541 15.688 None -72.19, -175.35 -58.86, 135.81 -72.29, -35.25 299.46, 167.83 -65.13, -41.68 in-in in 7.487 Saltbr-in 2.81 HRD-in -74.4, -54.18 84.68, -14.66 in-out-out SNCioo out-out ActLoopNT-out 10.601 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -51.93 APE9-dihe-in -104.69, 112.5 APE8-dihe-in -81.62, 64.47 APE8-rot-na 30.93 APE67-dihe-in -65.67, -8.67 -53.83, -41.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.446 APE9-dist-out 8.987 None None None XRAY 1.925 0.193 0.218 B 282 258 13 0 0 13 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YR9C Q05397 414 686 1052.0 P9K:701 Type1 Inactive DFGin 6.707 15.696 None -74.62, -175.14 -58.39, 136.31 -73.32, -36.06 298.17, 169.43 -64.54, -38.88 in-in in 7.476 Saltbr-in 2.802 HRD-in -67.84, -54.81 84.4, -10.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.96 APE8-dihe-in -83.91, 65.47 APE8-rot-na 32.43 APE67-dihe-in -66.56, -9.09 -55.03, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.579 None None None XRAY 1.925 0.193 0.218 C 282 258 15 0 0 15 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YR9D Q05397 412 685 1052.0 P9K:701 Type1 Inactive DFGin 6.849 15.9 None -73.97, -177.5 -59.32, 135.48 -74.09, -34.16 299.25, 167.14 -64.12, -40.48 in-in in 7.483 Saltbr-in 2.803 HRD-in -67.32, -56.9 82.13, -9.82 in-out-out SNCioo out-out ActLoopNT-out 11.925 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.57 APE8-dihe-in -85.42, 67.52 APE8-rot-na 30.81 APE67-dihe-in -67.68, -8.19 -56.08, -39.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.51 None None None XRAY 1.925 0.193 0.218 D 282 262 12 0 0 12 [[422, 678]] 1.0 6yr9 Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVSB Q05397 415 686 1052.0 PVT:701 Type1 Inactive DFGin 6.571 16.04 None -126.79, -3.83 -122.97, 123.34 -125.84, 999.0 281.41, 69.18 999.0, 999.0 in-in in 7.981 Saltbr-in 2.894 HRD-in -66.74, -51.12 77.94, -4.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.44 APE8-dihe-in -83.24, 64.15 APE8-rot-na 28.78 APE67-dihe-in -64.0, -16.76 -48.41, -44.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.19 None None None XRAY 1.81 0.193 0.215 B 282 254 18 0 0 18 [[422, 678]] 1.0 6yvs Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVSD Q05397 412 686 1052.0 PVT:701 Type1 Inactive DFGin 7.132 16.183 None -76.03, -175.56 -60.31, 138.69 -87.68, 999.0 305.08, 167.36 999.0, 999.0 in-in in 7.49 Saltbr-in 2.759 HRD-in -66.73, -51.22 77.37, -3.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.69 APE8-dihe-in -83.36, 63.72 APE8-rot-na 28.67 APE67-dihe-in -66.21, -12.54 -49.68, -44.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.298 None None None XRAY 1.81 0.193 0.215 D 282 257 18 0 0 18 [[422, 678]] 1.0 6yvs Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVYC Q05397 411 686 1052.0 P1E:802 Type1 Inactive DFGin 6.99 16.362 None -69.66, 178.7 -62.98, 133.91 -77.95, 999.0 300.74, 174.12 999.0, 999.0 in-in in 7.526 Saltbr-in 2.733 HRD-in -68.55, -50.55 78.07, -8.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.77 APE8-dihe-in -81.84, 60.78 APE8-rot-na 33.33 APE67-dihe-in -67.16, -11.03 -46.06, -44.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.188 None None None XRAY 1.918 0.215 0.235 C 282 258 18 0 0 18 [[422, 678]] 1.0 6yvy Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVYD Q05397 415 686 1052.0 P1E:701 Type1 Inactive DFGin 7.055 14.87 None -121.81, -169.66 55.51, 105.08 -131.24, 999.0 291.45, 85.32 999.0, 999.0 in-out in 7.992 Saltbr-out 4.533 HRD-in -68.69, -50.74 77.4, -7.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 145.59 APE9-dihe-in -72.33, 140.74 APE8-dihe-in -81.37, 62.58 APE8-rot-na 30.99 APE67-dihe-in -64.82, -12.74 -48.02, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.303 None None None XRAY 1.918 0.215 0.235 D 282 255 17 0 0 17 [[422, 678]] 1.0 6yvy Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YXVA Q05397 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.78 15.896 None -74.38, 172.96 -50.5, 132.87 -70.58, -33.64 295.92, 176.86 -68.7, -41.79 in-in in 7.506 Saltbr-in 2.74 HRD-in -63.96, -44.94 72.24, 2.92 in-out-out SNCioo out-out ActLoopNT-out 11.958 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.63 APE8-dihe-in -85.47, 62.62 APE8-rot-na 31.57 APE67-dihe-in -70.39, -3.07 -47.35, -41.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.299 None None None XRAY 2.298 0.203 0.232 A 282 261 12 0 0 12 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YXVB Q05397 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.75 15.916 None -75.08, 173.66 -51.87, 131.63 -68.87, -32.97 295.29, 177.69 -68.78, -48.08 in-in in 7.657 Saltbr-in 2.741 HRD-in -62.92, -46.64 75.37, -2.33 in-out-out SNCioo out-out ActLoopNT-out 11.978 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.82 APE8-dihe-in -86.78, 62.62 APE8-rot-na 30.42 APE67-dihe-in -70.82, -2.85 -47.09, -41.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.187 None None None XRAY 2.298 0.203 0.232 B 282 260 12 0 0 12 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YXVC Q05397 414 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.9 16.032 None -74.5, 172.75 -51.5, 132.3 -71.72, -29.34 296.05, 175.78 -71.46, -48.84 in-in in 7.501 Saltbr-in 2.743 HRD-in -62.86, -46.42 73.82, -1.43 in-out-out SNCioo out-out ActLoopNT-out 12.077 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -77.88, 152.47 APE9-dihe-in -135.02, 147.01 APE8-dihe-in -86.57, 63.93 APE8-rot-na 30.34 APE67-dihe-in -70.64, -1.8 -47.53, -42.32 APE12-dist-na 999.0 APE11-dist-na 16.304 APE10-dist-na 14.536 APE9-dist-out 8.235 None None None XRAY 2.298 0.203 0.232 C 282 265 8 0 0 8 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YXVD Q05397 415 686 1052.0 Q2H:701 Type1 Inactive DFGin 6.547 15.91 None -69.88, 170.62 -49.04, 129.98 -64.73, -39.06 297.56, 170.69 -61.08, -44.2 in-in in 7.624 Saltbr-in 2.772 HRD-in -62.37, -45.76 74.99, -1.97 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.03 APE8-dihe-in -85.67, 62.63 APE8-rot-na 30.22 APE67-dihe-in -70.22, -2.35 -46.36, -42.68 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.323 None None None XRAY 2.298 0.203 0.232 D 282 257 15 0 0 15 [[422, 678]] 1.0 6yxv Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4EBWA Q05397 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.52 8.023 None -156.77, 167.19 -119.55, 38.35 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.232 Saltbr-in 3.021 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-out 9.391 None None None XRAY 2.65 0.186 0.273 A 304 259 17 0 0 15 [[422, 678]] 1.0 4ebw Homo sapiens TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4KAOA Q05397 415 686 1052.0 KAO:701 Type2 Inactive DFGout 12.066 12.278 BBAminus -134.79, -162.64 -155.55, 104.45 -106.77, 12.18 324.82, 118.68 -116.51, 999.0 in-in in 7.599 Saltbr-in 2.978 HRD-in -70.26, -42.49 72.38, -8.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.11 APE8-dihe-in -88.07, 63.25 APE8-rot-na 31.2 APE67-dihe-in -68.79, -9.04 -44.98, -42.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.509 P410G None None XRAY 2.39 0.183 0.216 A 282 252 20 0 0 17 [[422, 678]] 1.0 4kao Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4KAOB Q05397 414 686 1052.0 KAO:701 Type2 Inactive DFGout 12.124 11.277 BBAminus -133.46, -165.55 -153.36, 103.98 -106.18, 16.19 323.24, 119.54 -120.71, 999.0 in-out in 7.429 Saltbr-out 3.735 HRD-in -70.44, -42.65 72.16, -8.69 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.77 APE8-dihe-in -89.23, 64.34 APE8-rot-na 31.44 APE67-dihe-in -70.06, -9.42 -44.78, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.281 P410G None None XRAY 2.39 0.183 0.216 B 282 254 19 0 0 17 [[422, 678]] 1.0 4kao Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4EBVA Q05397 411 686 1052.0 0O7:60700 Type1 Inactive DFGout 11.175 7.51 None -148.69, 172.25 -125.22, 28.16 -145.3, 162.48 59.08, 99.54 -99.68, 159.32 in-in in 7.379 Saltbr-in 2.766 HRD-out -69.43, 120.16 -87.06, -29.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 152.82 APE9-dihe-in -71.94, 140.54 APE8-dihe-in -84.59, 69.22 APE8-rot-na 32.8 APE67-dihe-in -63.36, -17.19 -49.83, -44.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.246 APE9-dist-out 8.976 None None None XRAY 1.67 0.19 0.236 A 304 261 15 0 0 15 [[422, 678]] 1.0 4ebv Homo sapiens TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4K9YA Q05397 415 685 1052.0 K9Y:701 Type2 Inactive DFGout 11.689 11.327 None -136.41, -157.16 -158.41, 138.01 -138.83, 152.71 305.51, 94.43 129.5, 144.14 in-in in 7.426 Saltbr-in 2.717 HRD-in -74.16, -44.03 80.75, -11.87 in-out-out SNCioo out-out ActLoopNT-out 11.712 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -104.89, 17.11 APE9-dihe-in -58.83, 133.83 APE8-dihe-in -80.92, 57.36 APE8-rot-na 33.68 APE67-dihe-in -69.17, -13.81 -45.78, -40.4 APE12-dist-na 9.884 APE11-dist-na 13.533 APE10-dist-na 9.909 APE9-dist-out 9.064 None None None XRAY 2.0 0.165 0.189 A 279 271 0 0 0 0 [[422, 678]] 1.0 4k9y Homo sapiens TYR_PTK2_HUMAN TYR 3.4e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4I4FA Q05397 415 686 1052.0 1BR:702 Type3 Inactive DFGout 13.674 8.178 None -137.25, -178.53 -131.85, 30.21 -146.33, 163.88 55.94, 90.52 -101.82, 157.06 out-out out 10.618 Saltbr-out 6.191 HRD-out -98.84, 110.46 -92.47, -29.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 158.93 APE9-dihe-in -71.56, 140.23 APE8-dihe-in -82.88, 69.99 APE8-rot-na 31.14 APE67-dihe-in -67.42, -12.73 -49.69, -43.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.614 APE9-dist-out 8.777 None None None XRAY 1.75 0.188 0.228 A 281 255 17 0 0 14 [[422, 678]] 1.0 4i4f Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 1MP8A Q05397 414 686 1052.0 ADP:800 ATPlike Inactive None 999.0 999.0 None -89.07, -172.44 90.39, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.446 Saltbr-in 3.097 HRD-in -74.41, -44.19 70.37, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.38 APE8-dihe-in -79.05, 61.98 APE8-rot-na 29.35 APE67-dihe-in -62.59, -13.79 -46.47, -46.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.07 None None None XRAY 1.6 0.188 0.23 A 281 252 21 0 0 19 [[422, 678]] 1.0 1mp8 Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 4Q9SA Q05397 414 686 1052.0 30G:701 Type1 Inactive None 999.0 999.0 None -108.96, -162.28 105.66, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.119 Saltbr-in 3.587 HRD-in -69.46, -51.39 76.26, -10.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.19 APE8-dihe-in -85.37, 63.73 APE8-rot-na 29.34 APE67-dihe-in -65.56, -17.14 -46.98, -40.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.572 None None None XRAY 2.07 0.216 0.216 A 281 252 21 0 0 19 [[422, 678]] 1.0 4q9s Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_HUMAN 6YVSC Q05397 414 686 1052.0 PVT:701 Type1 Inactive None 999.0 999.0 None -89.33, -115.17 -25.15, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-out in 7.598 Saltbr-out 3.897 HRD-in -66.68, -50.09 76.47, -4.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.62 APE8-dihe-in -83.55, 64.26 APE8-rot-na 28.32 APE67-dihe-in -65.5, -13.99 -48.94, -44.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.22 None None None XRAY 1.81 0.193 0.215 C 282 254 19 0 0 19 [[422, 678]] 1.0 6yvs Homo sapiens TYR_PTK2_HUMAN TYR 3.6e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1

TYR_PTK2 (Focal adhesion kinase 1)

Total number of chains: 34
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 23 67.6% 4D4RB
DFGin ABAminus 7 20.6% 4D5HB
DFGin BLAminus 4 11.8% 2J0LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FAK1_CHICK 6TY4A Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.951 BLAminus -124.05, -151.88 51.86, 82.13 -107.99, 32.9 286.39, 85.0 -72.01, -36.58 in-in in 8.437 Saltbr-in 3.562 HRD-in -70.16, -30.0 74.19, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.31, 66.54 APE9-dihe-in -63.31, 139.75 APE8-dihe-in -64.41, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.19, -42.03 -70.19, -41.73 APE12-dist-na 11.489 APE11-dist-na 10.184 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 A 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6TY4B Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.95 BLAminus -124.03, -151.9 51.82, 82.14 -107.99, 32.89 286.33, 85.06 -71.97, -36.56 in-in in 8.436 Saltbr-in 3.562 HRD-in -70.15, -30.0 74.26, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.3, 66.56 APE9-dihe-in -63.34, 139.79 APE8-dihe-in -64.42, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.21, -42.01 -70.19, -41.71 APE12-dist-na 11.489 APE11-dist-na 10.183 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 B 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4VA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 6.123 15.291 ABAminus -122.16, -1.29 -156.99, 122.18 -126.9, 31.66 293.34, 65.98 -81.63, 999.0 in-in in 7.996 Saltbr-in 3.083 HRD-in -77.87, -48.56 83.88, -10.61 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -77.09 APE9-dihe-in -94.72, 136.23 APE8-dihe-in -75.22, 70.94 APE8-rot-na 27.07 APE67-dihe-in -66.52, -13.67 -58.3, -42.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.275 None None None XRAY 2.1 0.194 0.227 A 276 256 16 0 0 16 [[422, 678]] 1.0 4d4v Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4YB Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 4.973 14.875 ABAminus -115.15, -9.04 -143.75, 141.85 -120.63, 30.55 291.39, 86.7 127.93, -31.58 in-out in 7.743 Saltbr-out 5.056 HRD-in -80.84, -45.71 75.75, -7.5 out-out-none SNCoon out-none ActLoopNT-out 13.423 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.74 APE8-dihe-in -83.87, 62.32 APE8-rot-na 37.29 APE67-dihe-in -68.22, -16.82 -56.29, -37.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.947 None None None XRAY 1.8 0.189 0.227 B 276 260 12 0 0 12 [[422, 678]] 1.0 4d4y Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5HB Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.01 14.915 ABAminus -118.07, -3.03 -146.77, 140.81 -121.95, 32.65 292.91, 91.31 127.85, -27.62 in-out in 7.803 Saltbr-out 4.855 HRD-in -83.42, -46.05 77.42, -4.17 out-out-none SNCoon out-none ActLoopNT-out 13.409 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.03 APE8-dihe-in -83.38, 65.56 APE8-rot-na 33.73 APE67-dihe-in -67.49, -15.11 -52.74, -41.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.842 None None None XRAY 1.75 0.183 0.205 B 276 260 12 0 0 12 [[422, 678]] 1.0 4d5h Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5KB Q00944 414 686 1053.0 No_ligand No_ligand Inactive DFGin 5.36 14.849 ABAminus -119.1, -4.63 -144.03, 135.87 -122.31, 26.55 292.91, 81.98 158.26, 999.0 in-out in 7.796 Saltbr-out 4.851 HRD-in -79.88, -47.37 77.23, -5.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -10.29 APE8-dihe-in -82.63, 60.08 APE8-rot-na 35.57 APE67-dihe-in -68.96, -15.52 -58.72, -35.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.605 None None None XRAY 1.75 0.19 0.214 B 276 256 17 0 0 17 [[422, 678]] 1.0 4d5k Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4SB Q00944 415 686 1053.0 BI9:1690 Type1 Inactive DFGin 5.45 14.621 ABAminus -111.11, -16.99 -125.52, 154.32 -137.31, 52.23 289.14, 82.0 97.11, -19.33 in-out in 7.76 Saltbr-out 4.556 HRD-in -75.76, -49.0 80.94, -1.24 out-out-none SNCoon out-none ActLoopNT-out 13.101 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.21 APE8-dihe-in -84.28, 68.41 APE8-rot-na 35.3 APE67-dihe-in -65.5, -16.9 -56.56, -40.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.965 None None None XRAY 2.0 0.207 0.225 B 276 260 12 0 0 12 [[422, 678]] 1.0 4d4s Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4VB Q00944 415 686 1053.0 KB8:1691 Type1 Inactive DFGin 5.85 15.047 ABAminus -117.73, -0.74 -150.12, 135.85 -127.11, 29.12 290.68, 71.34 130.97, 999.0 in-out in 7.955 Saltbr-out 3.76 HRD-in -79.54, -48.18 78.6, -9.72 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.73 APE8-dihe-in -85.06, 62.84 APE8-rot-na 36.16 APE67-dihe-in -65.92, -16.26 -53.87, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.119 None None None XRAY 2.1 0.194 0.227 B 276 255 17 0 0 17 [[422, 678]] 1.0 4d4v Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D58B Q00944 414 686 1053.0 BI9:1690 Type1 Inactive DFGin 5.343 14.773 ABAminus -111.98, -14.84 -133.5, 141.08 -122.5, 41.04 291.15, 84.59 117.31, -28.78 in-out in 7.706 Saltbr-out 4.368 HRD-in -80.65, -46.47 80.81, -10.05 out-out-out SNCooo out-out ActLoopNT-out 13.028 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.24 APE8-dihe-in -85.92, 64.4 APE8-rot-na 36.67 APE67-dihe-in -68.12, -12.82 -55.14, -41.45 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.205 None None None XRAY 1.95 0.197 0.228 B 276 261 12 0 0 12 [[422, 678]] 1.0 4d58 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0LA Q00944 411 686 1053.0 ANP:1689 ATPlike Inactive DFGin 7.042 15.595 BLAminus -124.12, -151.88 51.86, 82.15 -108.03, 32.91 286.36, 85.03 -71.96, -36.63 in-in in 7.824 Saltbr-in 2.777 HRD-in -78.92, -53.9 78.76, -8.92 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.98, 100.38 APE9-dihe-in -65.3, 130.79 APE8-dihe-in -75.31, 71.06 APE8-rot-na 28.66 APE67-dihe-in -69.29, -16.82 -49.9, -41.21 APE12-dist-na 11.387 APE11-dist-na 10.256 APE10-dist-na 13.533 APE9-dist-out 8.279 None PTR576,PTR577 PTR576,PTR577 XRAY 2.3 0.217 0.263 A 276 276 0 0 0 0 [[422, 678]] 1.0 2j0l Gallus gallus TYR_PTK2_CHICK TYR 2.6e-93 318.0 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4RA Q00944 414 685 1053.0 No_ligand No_ligand Inactive DFGin 6.753 16.315 None -128.64, 175.12 33.48, 60.17 -127.21, 999.0 60.14, 81.77 999.0, 999.0 in-out in 7.554 Saltbr-out 4.275 HRD-in -77.09, -46.72 78.72, -6.1 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.07 APE8-dihe-in -82.55, 72.75 APE8-rot-na 32.3 APE67-dihe-in -68.58, -11.96 -57.72, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.677 None None None XRAY 1.55 0.202 0.221 A 276 251 21 0 0 18 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4RB Q00944 412 684 1053.0 No_ligand No_ligand Inactive DFGin 7.023 17.736 None -78.09, 178.28 -54.92, 128.48 -75.07, -16.05 303.31, 165.11 -65.19, -11.08 out-out out 10.231 Saltbr-out 10.2 HRD-in -77.54, -48.96 77.86, -1.75 out-out-none SNCoon out-none ActLoopNT-out 10.051 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.59 APE8-dihe-in -81.78, 61.99 APE8-rot-na 34.83 APE67-dihe-in -67.78, -12.73 -54.67, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.78 None None None XRAY 1.55 0.202 0.221 B 276 270 3 0 0 3 [[422, 678]] 1.0 4d4r Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4SA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.335 14.49 None -114.18, -4.67 -150.83, 135.97 -129.43, 999.0 291.59, 99.53 999.0, 999.0 in-in in 7.87 Saltbr-in 2.988 HRD-in -76.62, -49.37 85.0, -10.92 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 143.71 APE9-dihe-in -71.69, 139.37 APE8-dihe-in -80.22, 72.42 APE8-rot-na 32.17 APE67-dihe-in -66.95, -17.13 -56.96, -41.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.103 None None None XRAY 2.0 0.207 0.225 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d4s Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D4YA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.018 14.514 None -118.29, -10.26 -147.25, 131.73 -119.37, 999.0 297.41, 102.39 999.0, 999.0 in-in in 7.798 Saltbr-in 2.444 HRD-in -81.89, -51.68 81.97, -7.7 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -42.9 APE9-dihe-in -67.29, 140.52 APE8-dihe-in -79.28, 66.93 APE8-rot-na 16.31 APE67-dihe-in -68.8, -8.86 -56.17, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.251 None None None XRAY 1.8 0.189 0.227 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d4y Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D58A Q00944 414 686 1053.0 No_ligand No_ligand Inactive DFGin 5.448 14.95 None -119.32, -6.79 -143.39, 120.13 -112.99, 999.0 292.94, 94.83 999.0, 999.0 in-in in 8.204 Saltbr-in 2.717 HRD-in -82.22, -48.88 82.65, -10.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.86 APE8-dihe-in -79.5, 65.59 APE8-rot-na 31.69 APE67-dihe-in -68.56, -13.14 -56.02, -40.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 None None None XRAY 1.95 0.197 0.228 A 276 255 18 0 0 18 [[422, 678]] 1.0 4d58 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5KA Q00944 415 686 1053.0 No_ligand No_ligand Inactive DFGin 5.582 15.122 None -117.73, -5.95 -151.01, 133.04 -124.81, 999.0 284.01, 85.38 999.0, 999.0 in-in in 7.888 Saltbr-in 3.584 HRD-in -86.7, -47.97 80.45, -6.37 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -43.63 APE9-dihe-in -60.17, 136.23 APE8-dihe-in -79.08, 66.16 APE8-rot-na 27.0 APE67-dihe-in -72.5, -9.93 -52.21, -39.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.233 None None None XRAY 1.75 0.19 0.214 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d5k Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6TY3A Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.567 14.452 None -135.16, 170.63 86.31, -91.36 58.85, 65.75 299.77, 89.22 -131.55, 157.07 in-out in 8.259 Saltbr-out 3.768 HRD-in -98.85, -42.65 73.64, -10.05 out-out-out SNCooo out-out ActLoopNT-out 12.361 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.38, 179.3 APE9-dihe-in -128.41, 160.02 APE8-dihe-in -77.79, 72.21 APE8-rot-na 27.16 APE67-dihe-in -64.5, -27.16 -60.23, -43.57 APE12-dist-na 14.964 APE11-dist-na 15.593 APE10-dist-na 17.373 APE9-dist-out 8.629 None None None EM 6.32 999.0 999.0 A 658 600 10 0 0 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6TY3B Q00944 35 686 1053.0 No_ligand No_ligand Inactive DFGin 6.567 14.451 None -135.19, 170.62 86.26, -91.32 58.84, 65.75 299.77, 89.17 -131.52, 157.04 in-out in 8.259 Saltbr-out 3.767 HRD-in -98.85, -42.61 73.64, -10.1 out-out-out SNCooo out-out ActLoopNT-out 12.36 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -84.36, 179.28 APE9-dihe-in -128.39, 160.01 APE8-dihe-in -77.75, 72.19 APE8-rot-na 27.19 APE67-dihe-in -64.56, -27.16 -60.28, -43.5 APE12-dist-na 14.965 APE11-dist-na 15.594 APE10-dist-na 17.373 APE9-dist-out 8.63 None None None EM 6.32 999.0 999.0 B 658 600 10 0 0 10 [[422, 678]] 1.0 6ty3 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKMA Q00944 413 686 1053.0 BII:1687 Type1 Inactive DFGin 6.979 15.597 None -114.99, -166.2 1.63, 119.82 87.35, -47.95 314.75, 124.67 -93.91, 178.82 in-in in 7.425 Saltbr-in 2.805 HRD-in -72.67, -52.48 88.19, -13.59 in-out-out SNCioo out-out ActLoopNT-out 14.999 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 118.01 APE8-dihe-in -71.46, 57.0 APE8-rot-na 27.37 APE67-dihe-in -75.95, 0.41 -40.68, -47.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 None None None XRAY 2.31 0.211 0.272 A 276 260 14 0 0 14 [[422, 678]] 1.0 2jkm Gallus gallus TYR_PTK2_CHICK TYR 1.4e-93 318.9 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0MB Q00944 414 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.972 14.287 None -122.76, 167.67 145.4, -137.08 -124.29, 100.35 290.36, 64.77 -132.69, 154.11 in-in in 7.468 Saltbr-in 2.443 HRD-in -71.25, -49.34 81.19, -3.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.23 APE8-dihe-in -85.72, 66.92 APE8-rot-na 31.09 APE67-dihe-in -64.84, -11.69 -52.92, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.379 None None None XRAY 2.8 0.224 0.282 B 276 257 16 0 0 16 [[422, 678]] 1.0 2j0m Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKQA Q00944 414 686 1053.0 VG8:1687 Type1 Inactive DFGin 6.434 15.77 None -75.88, 179.74 -51.42, 124.37 -59.35, -36.75 304.41, 5.5 -52.05, -42.43 in-in in 7.494 Saltbr-in 2.623 HRD-in -66.06, -52.83 77.77, -12.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.31 APE8-dihe-in -81.47, 65.67 APE8-rot-na 31.77 APE67-dihe-in -69.2, -7.68 -48.0, -45.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.883 None None None XRAY 2.6 0.217 0.262 A 276 258 15 0 0 15 [[422, 678]] 1.0 2jkq Gallus gallus TYR_PTK2_CHICK TYR 3.3e-93 317.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKKA Q00944 413 684 1053.0 BI9:1686 Type1 Inactive DFGin 6.662 15.946 None -75.15, -171.72 -62.78, 135.39 -69.82, -36.92 292.96, 7.69 -58.64, -47.49 in-in in 7.466 Saltbr-in 2.795 HRD-in -67.23, -54.57 79.75, -14.16 in-out-none SNCion out-none ActLoopNT-out 10.52 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.56 APE8-dihe-in -81.25, 65.87 APE8-rot-na 28.94 APE67-dihe-in -64.8, -17.36 -41.67, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.961 None None None XRAY 2.0 0.182 0.236 A 276 258 14 0 0 14 [[422, 678]] 1.0 2jkk Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2JKOA Q00944 415 686 1053.0 BIJ:1687 Type1 Inactive DFGin 6.824 16.288 None -76.65, 177.09 -51.97, 132.66 -73.02, -22.84 294.23, 6.85 -74.57, -42.86 in-in in 8.264 Saltbr-in 3.576 HRD-in -81.96, -48.92 77.27, -4.29 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.22 APE8-dihe-in -78.31, 62.64 APE8-rot-na 29.54 APE67-dihe-in -67.04, -13.81 -48.71, -43.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.932 None None None XRAY 1.65 0.19 0.217 A 276 256 16 0 0 16 [[422, 678]] 1.0 2jko Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4BRXA Q00944 413 684 1053.0 KGW:1685 Type1 Inactive DFGin 6.567 15.804 None -85.04, -171.69 -52.6, 140.21 -75.53, -32.77 290.76, 3.08 -64.53, -44.35 in-in in 7.276 Saltbr-in 2.817 HRD-in -72.91, -56.18 75.54, -1.8 in-out-out SNCioo out-out ActLoopNT-out 10.429 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 113.09 APE8-dihe-in -77.77, 68.02 APE8-rot-na 18.27 APE67-dihe-in -64.57, -19.31 -48.57, -44.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.203 None None None XRAY 2.05 0.199 0.239 A 276 260 12 0 0 12 [[422, 678]] 1.0 4brx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4C7TA Q00944 414 684 1053.0 5RI:1685 Type1 Inactive DFGin 6.533 15.84 None -77.4, -179.92 -52.87, 136.35 -71.95, -38.06 294.7, 1.19 -59.39, -44.61 in-in in 7.517 Saltbr-in 2.969 HRD-in -72.59, -59.08 84.11, -4.81 in-out-none SNCion out-none ActLoopNT-out 10.431 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.59 APE8-dihe-in -78.35, 70.91 APE8-rot-na 26.06 APE67-dihe-in -65.2, -16.6 -50.79, -47.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.893 None None None XRAY 2.05 0.22 0.246 A 276 259 12 0 0 12 [[422, 678]] 1.0 4c7t Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D5HA Q00944 415 686 1053.0 9RM:1687 Type1 Inactive DFGin 8.789 16.179 None -119.76, -8.44 -152.2, 131.56 -67.1, 999.0 180.84, 34.18 999.0, 999.0 in-out in 7.91 Saltbr-out 3.715 HRD-in -79.33, -48.38 80.51, -4.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.09 APE9-dihe-in -60.1, 142.63 APE8-dihe-in -82.47, 68.46 APE8-rot-na 31.45 APE67-dihe-in -67.73, -13.99 -56.02, -40.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.168 None None None XRAY 1.75 0.183 0.205 A 276 255 17 0 0 17 [[422, 678]] 1.0 4d5h Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCRA Q00944 413 684 1053.0 EUW:701 Type1 Inactive DFGin 6.738 16.103 None -70.87, -166.97 -65.32, 125.1 -57.74, -34.57 287.47, 8.46 -73.02, -37.86 in-in in 7.567 Saltbr-in 2.463 HRD-in -75.05, -55.09 81.04, -5.76 in-out-out SNCioo out-out ActLoopNT-out 10.419 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.27 APE8-dihe-in -77.73, 61.32 APE8-rot-na 29.84 APE67-dihe-in -67.52, -6.96 -49.75, -48.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.358 None None None XRAY 2.3 0.214 0.262 A 276 258 14 0 0 14 [[422, 678]] 1.0 6gcr Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCWA Q00944 414 685 1053.0 EUQ:701 Type1 Inactive DFGin 6.285 15.228 None -130.25, -162.76 64.22, 75.01 -107.3, 999.0 290.51, 75.53 999.0, 999.0 in-out in 8.033 Saltbr-out 4.377 HRD-in -81.64, -46.43 83.77, -4.99 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.84 APE8-dihe-in -78.48, 68.9 APE8-rot-na 34.42 APE67-dihe-in -73.52, -10.12 -55.06, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.395 None None None XRAY 2.0 0.22 0.274 A 276 254 18 0 0 18 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCWB Q00944 414 686 1053.0 EUQ:701 Type1 Inactive DFGin 6.539 15.837 None -81.1, -172.36 -60.09, 131.66 -68.99, -32.35 293.15, 10.83 -65.72, -42.14 in-in in 7.573 Saltbr-in 2.679 HRD-in -76.57, -51.51 74.74, 1.93 in-out-out SNCioo out-out ActLoopNT-out 11.07 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.67 APE8-dihe-in -80.93, 60.16 APE8-rot-na 31.79 APE67-dihe-in -70.89, -7.66 -53.84, -42.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.822 None None None XRAY 2.0 0.22 0.274 B 276 259 14 0 0 14 [[422, 678]] 1.0 6gcw Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 6GCXA Q00944 413 686 1053.0 EUW:701 Type1 Inactive DFGin 6.779 16.445 None -72.0, 177.39 -57.13, 134.48 -70.38, -29.96 294.86, 177.92 -65.58, -46.38 in-in in 8.091 Saltbr-in 3.047 HRD-in -82.56, -49.93 78.9, -6.95 in-out-out SNCioo out-out ActLoopNT-out 10.846 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.29 APE8-dihe-in -79.72, 63.89 APE8-rot-na 33.8 APE67-dihe-in -69.74, -9.01 -53.44, -42.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.009 None None None XRAY 1.553 0.186 0.219 A 276 258 16 0 0 14 [[422, 678]] 1.0 6gcx Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0JA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.918 14.385 None -123.19, 169.5 101.29, -103.63 66.49, 28.41 317.16, 97.31 -90.27, 177.52 in-in in 8.119 Saltbr-in 2.703 HRD-in -78.32, -40.43 79.32, -8.22 in-out-out SNCioo out-out ActLoopNT-out 12.463 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.84 APE8-dihe-in -80.69, 57.63 APE8-rot-na 26.07 APE67-dihe-in -61.42, -10.9 -40.75, -50.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.849 None None None XRAY 2.8 0.22 0.274 A 656 611 10 0 0 10 [[422, 678]] 1.0 2j0j Gallus gallus TYR_PTK2_CHICK TYR 3.1e-92 314.9 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0KA Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.84 14.522 None -94.55, -93.91 -78.14, -58.62 58.67, 36.74 310.17, 120.14 -115.82, 158.23 in-in in 8.167 Saltbr-in 2.834 HRD-in -98.8, -33.31 77.39, -21.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 52.29 APE9-dihe-in -82.72, 133.73 APE8-dihe-in -69.87, 64.39 APE8-rot-na 25.61 APE67-dihe-in -58.59, -19.95 -50.1, -51.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.019 APE9-dist-out 8.81 None None None XRAY 3.0 0.237 0.299 A 656 598 15 0 0 15 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 2J0KB Q00944 35 686 1053.0 4ST:1687 Type1 Inactive DFGin 6.8 13.944 None -96.91, -85.38 -80.15, -63.34 50.19, 5.1 328.51, 122.72 -57.61, 145.44 in-in in 8.042 Saltbr-in 3.114 HRD-in -78.83, -42.91 75.23, -10.09 in-out-out SNCioo out-out ActLoopNT-out 10.513 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -80.14, 57.93 APE8-rot-na 30.91 APE67-dihe-in -67.94, -7.65 -42.39, -46.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.247 None None None XRAY 3.0 0.237 0.299 B 656 612 14 0 0 14 [[422, 678]] 1.0 2j0k Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
FAK1_CHICK 4D55A Q00944 413 685 1053.0 No_ligand No_ligand None DFGin 6.834 15.362 BLAminus -129.2, -159.95 50.2, 79.76 -106.48, 46.83 298.83, 47.66 -60.24, -40.26 in-in in 7.559 Saltbr-in 3.312 HRD-in -79.77, -47.22 74.9, 2.93 in-in-none SNCiin in-none ActLoopNT-in 3.111 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.67 APE8-dihe-in -81.31, 64.05 APE8-rot-na 32.07 APE67-dihe-in -63.23, -12.78 -45.98, -50.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.641 None None None XRAY 2.3 0.201 0.257 A 276 260 13 0 0 13 [[422, 678]] 1.0 4d55 Gallus gallus TYR_PTK2_CHICK TYR 1.2e-92 315.8 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1