KinCore

AGC_PRKCB (Protein kinase C beta type)

Total number of chains: 12

Active chains: 6

Uniprot: KPCB_HUMAN

Kinase Domain Residues: 342 - 600

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	7	58.3%	AF-P05771-K1A
DFGin	ABAminus	4	33.3%	8SE3A
DFGin	None	1	8.3%	9S9TA

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PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
8SE1A	3.32	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	19 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
8SE1B	3.32	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	19 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
8SE2B	2.95	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	30 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
AF-P05771-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	334 - 608	0	None	None	Protein kinase C beta type
AF-P05771-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	334 - 608	0	None	None	Protein kinase C beta type
2I0EB	2.6	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	PDS	Type1	339 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
8SE2A	2.95	Inactive	DFGin‑ABAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iiii	No_ligand	No_ligand	19 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
8SE3A	2.6	Inactive	DFGin‑ABAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	30 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
8SE4A	2.68	Inactive	DFGin‑ABAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	19 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
8SE4B	2.68	Inactive	DFGin‑ABAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ADN	Type1	30 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
2I0EA	2.6	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iiii	PDS	Type1	339 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type
9S9TA	3.425	Inactive	DFGin‑None	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	LY4	Type1	340 - 667	0	TPO500,TPO642,SEP661	D427N	Protein kinase C beta type

AGC_PRKCB (Protein kinase C beta type)

Total number of chains: 13

Active chains: 6

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	8	61.5%	AF-P05771-K1A
DFGin	ABAminus	4	30.8%	8SE3A
DFGin	None	1	7.7%	9S9TA

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
KPCB_HUMAN	8SE1A	3.32	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	19 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	8SE1B	3.32	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	19 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	8SE2B	2.95	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	30 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	AF-P05771-K1A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	334 - 608	0	None	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	AF-P05771-K3A	-1.0	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	334 - 608	0	None	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	2I0EB	2.6	Active	DFGin‑BLAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	PDS	Type1	339 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	8SE2A	2.95	Inactive	DFGin‑ABAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iiii	No_ligand	No_ligand	19 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	8SE3A	2.6	Inactive	DFGin‑ABAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	30 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	8SE4A	2.68	Inactive	DFGin‑ABAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	No_ligand	No_ligand	19 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	8SE4B	2.68	Inactive	DFGin‑ABAminus	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ADN	Type1	30 - 671	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	2I0EA	2.6	Inactive	DFGin‑BLAminus	in-in	in-out	nonTYR	APEdihe_aaioi	APEdist_iiii	PDS	Type1	339 - 668	0	TPO500,TPO642,SEP661	None	Protein kinase C beta type	Homo sapiens
KPCB_HUMAN	9S9TA	3.425	Inactive	DFGin‑None	in-in	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	LY4	Type1	340 - 667	0	TPO500,TPO642,SEP661	D427N	Protein kinase C beta type	Homo sapiens
KPCB_RAT	3PFQA	4.0	Inactive	DFGin‑BLAminus	in-out	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	101 - 668	0	TPO500,TPO642,SEP661	C71S,C217S,R622S	Protein kinase C beta type	Rattus norvegicus

AGC_PRKCB (Protein kinase C beta type)

Total number of chains: 1

Active chains: 0

Spatial label	Dihedral label	Number of Chains	Percent	Representative
DFGin	BLAminus	1	100.0%	3PFQA

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UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	APEtype	APEdihe	APEdist	Ligand	Ligand Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
KPCB_RAT	3PFQA	4.0	Inactive	DFGin‑BLAminus	in-out	in-in	nonTYR	APEdihe_aaiii	APEdist_iiii	ANP	ATPlike	101 - 668	0	TPO500,TPO642,SEP661	C71S,C217S,R622S	Protein kinase C beta type	Rattus norvegicus