AGC_PRKCB (Protein kinase C beta type)

Total number of chains: 12
Active chains: 6
Family: AGC
Uniprot: KPCB_HUMAN
Kinase Domain Residues: 342 - 600
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 58.3% AF-P05771-K1A
DFGin ABAminus 4 33.3% 8SE3A
DFGin None 1 8.3% 9S9TA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
8SE1A 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.007 12.839 BLAminus -130.5, -169.38 54.07, 70.37 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.337 Saltbr-in 2.524 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.16 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.88 APE11-dist-in 12.178 APE10-dist-in 6.66 APE9-dist-in 3.611 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674 607 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
8SE1B 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.093 12.778 BLAminus -130.75, -169.0 53.85, 70.09 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.312 Saltbr-in 2.216 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.722 APE11-dist-in 12.182 APE10-dist-in 6.709 APE9-dist-in 3.767 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674 631 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
8SE2B 30 671 671.0 ANP:701 ATPlike Active DFGin 5.706 12.737 BLAminus -122.79, -175.57 50.54, 85.22 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.675 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.634 APE11-dist-in 11.712 APE10-dist-in 6.223 APE9-dist-in 3.606 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se2 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AF-P05771-K1A 334 608 671.0 No_ligand No_ligand Active DFGin 5.973 13.023 BLAminus -104.35, -161.36 27.53, 84.09 -90.04, 16.15 301.5, 91.82 -59.68, -29.78 in-in in 8.617 Saltbr-in 2.673 HRD-in -85.78, -46.1 64.58, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.82, 162.82 APE9-dihe-na 121.92, 167.13 APE8-dihe-in -72.73, 133.23 APE8-rot-in 298.5 APE67-dihe-in -66.05, -23.0 -49.76, -45.57 APE12-dist-in 8.607 APE11-dist-in 11.905 APE10-dist-in 6.229 APE9-dist-in 3.484 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K1 AGC_PRKCB_HUMAN AGC 1.1e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AF-P05771-K3A 334 608 671.0 No_ligand No_ligand Active DFGin 5.745 13.195 BLAminus -110.85, -172.96 35.96, 94.12 -98.35, 13.42 304.83, 99.89 -60.51, -33.43 in-in in 8.348 Saltbr-in 2.666 HRD-in -84.51, -47.08 65.34, 1.87 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.41, 161.65 APE9-dihe-na 129.21, 169.52 APE8-dihe-in -83.16, 130.6 APE8-rot-in 297.23 APE67-dihe-in -58.28, -24.56 -44.92, -51.84 APE12-dist-in 8.731 APE11-dist-in 11.81 APE10-dist-in 6.251 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K3 AGC_PRKCB_HUMAN AGC 1.1e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
2I0EB 339 668 671.0 PDS:60902 Type1 Active DFGin 6.906 13.595 BLAminus -122.54, 163.63 74.87, 90.26 -109.7, 30.33 301.59, 90.18 -89.33, 11.84 in-in in 9.025 Saltbr-in 2.821 HRD-in -82.04, -48.12 70.57, -0.74 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.03, 175.5 APE9-dihe-na 106.77, 155.55 APE8-dihe-in -68.48, 122.99 APE8-rot-in 298.97 APE67-dihe-in -65.65, -22.82 -42.1, -37.43 APE12-dist-in 8.683 APE11-dist-in 12.143 APE10-dist-in 6.729 APE9-dist-in 3.821 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.237 0.29 B 353 300 0 0 0 0 [[342, 600]] 1.0 2i0e AGC_PRKCB_HUMAN AGC 2.7e-98 334.2 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
8SE2A 19 671 671.0 No_ligand No_ligand Inactive DFGin 5.952 13.518 ABAminus -120.86, -65.35 -78.48, 119.96 -110.31, 36.28 298.77, 95.28 -76.53, -5.12 in-in in 8.864 Saltbr-in 2.462 HRD-in -90.7, -48.87 74.08, -6.11 in-in-out SNCiio in-out ActLoopNT-in 3.071 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -164.48, 160.4 APE9-dihe-na 124.42, 177.98 APE8-dihe-in -99.65, 131.7 APE8-rot-out 40.31 APE67-dihe-in -65.28, -24.14 -48.32, -36.09 APE12-dist-in 8.794 APE11-dist-in 11.988 APE10-dist-in 6.578 APE9-dist-in 3.942 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 A 672 599 0 0 0 0 [[342, 600]] 1.0 8se2 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
8SE3A 30 671 671.0 No_ligand No_ligand Inactive DFGin 6.16 13.709 ABAminus -124.07, -33.29 -92.17, 109.74 -116.23, 25.27 297.34, 94.38 -70.45, -20.68 in-in in 8.566 Saltbr-in 2.703 HRD-in -81.86, -43.58 62.11, 4.49 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.91, 179.4 APE9-dihe-na 110.04, -177.12 APE8-dihe-in -93.25, 130.02 APE8-rot-in 297.18 APE67-dihe-in -66.06, -11.73 -57.55, -35.92 APE12-dist-in 8.833 APE11-dist-in 12.028 APE10-dist-in 6.473 APE9-dist-in 3.751 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.199 0.227 A 672 601 0 0 0 0 [[342, 600]] 1.0 8se3 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
8SE4A 19 671 671.0 No_ligand No_ligand Inactive DFGin 6.115 13.438 ABAminus -125.45, -34.56 -87.53, 113.0 -119.18, 39.24 297.28, 94.22 -76.92, -28.17 in-in in 8.425 Saltbr-in 2.542 HRD-in -88.36, -49.83 70.03, 0.79 in-in-in SNCiii in-in ActLoopNT-in 3.102 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.55, 163.91 APE9-dihe-na 116.91, 175.65 APE8-dihe-in -91.2, 128.82 APE8-rot-in 305.77 APE67-dihe-in -67.42, -22.74 -50.74, -31.22 APE12-dist-in 8.712 APE11-dist-in 11.868 APE10-dist-in 6.374 APE9-dist-in 3.878 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 A 672 599 0 0 0 0 [[342, 600]] 1.0 8se4 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
8SE4B 30 671 671.0 ADN:701 Type1 Inactive DFGin 5.738 12.971 ABAminus -126.66, -34.17 -84.97, 112.43 -117.68, 39.4 296.69, 93.7 -74.7, -30.34 in-in in 8.26 Saltbr-in 2.51 HRD-in -88.0, -50.22 70.29, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.54, 164.05 APE9-dihe-na 118.34, -179.99 APE8-dihe-in -91.65, 129.4 APE8-rot-in 306.62 APE67-dihe-in -69.42, -21.97 -51.1, -33.02 APE12-dist-in 8.632 APE11-dist-in 11.783 APE10-dist-in 6.261 APE9-dist-in 3.776 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se4 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
2I0EA 339 668 671.0 PDS:60901 Type1 Inactive DFGin 6.283 13.949 BLAminus -117.76, 167.96 68.91, 88.95 -103.35, 26.8 299.87, 102.06 -70.85, -19.44 in-in in 9.073 Saltbr-in 3.031 HRD-in -81.74, -50.98 74.78, 5.37 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.38, 168.45 APE9-dihe-na 114.4, 163.6 APE8-dihe-in -94.67, 130.59 APE8-rot-out 93.65 APE67-dihe-in -62.49, -23.91 -28.3, -54.88 APE12-dist-in 9.03 APE11-dist-in 11.905 APE10-dist-in 6.388 APE9-dist-in 4.046 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.237 0.29 A 353 327 0 0 0 0 [[342, 600]] 1.0 2i0e AGC_PRKCB_HUMAN AGC 2.7e-98 334.2 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
9S9TA 340 667 671.0 LY4:60701 Type1 Inactive DFGin 6.093 13.973 None -111.78, -89.62 -67.76, 129.93 -115.94, 12.83 282.89, 115.63 -69.35, -46.77 in-in in 8.522 Saltbr-in 2.723 HRD-in -57.71, -56.78 85.18, -40.4 in-in-in SNCiii in-in ActLoopNT-in 3.456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.66, 131.78 APE9-dihe-na 176.22, -177.75 APE8-dihe-in -90.0, 133.29 APE8-rot-in 321.38 APE67-dihe-in -84.35, -33.13 -46.48, -38.11 APE12-dist-in 8.313 APE11-dist-in 11.686 APE10-dist-in 5.752 APE9-dist-in 4.34 D427N TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.425 0.218 0.29 A 353 315 0 0 0 0 [[342, 600]] 1.0 9s9t AGC_PRKCB_HUMAN AGC 1.3e-97 332.0 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type

AGC_PRKCB (Protein kinase C beta type)

Total number of chains: 13
Active chains: 6
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 61.5% AF-P05771-K1A
DFGin ABAminus 4 30.8% 8SE3A
DFGin None 1 7.7% 9S9TA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KPCB_HUMAN 8SE1A P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.007 12.839 BLAminus -130.5, -169.38 54.07, 70.37 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.337 Saltbr-in 2.524 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.16 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.88 APE11-dist-in 12.178 APE10-dist-in 6.66 APE9-dist-in 3.611 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674 607 0 0 0 0 [[342, 600]] 1.0 8se1 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 8SE1B P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.093 12.778 BLAminus -130.75, -169.0 53.85, 70.09 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.312 Saltbr-in 2.216 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.722 APE11-dist-in 12.182 APE10-dist-in 6.709 APE9-dist-in 3.767 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674 631 0 0 0 0 [[342, 600]] 1.0 8se1 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 8SE2B P05771 30 671 671.0 ANP:701 ATPlike Active DFGin 5.706 12.737 BLAminus -122.79, -175.57 50.54, 85.22 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.675 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.634 APE11-dist-in 11.712 APE10-dist-in 6.223 APE9-dist-in 3.606 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se2 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN AF-P05771-K1A P05771 334 608 671.0 No_ligand No_ligand Active DFGin 5.973 13.023 BLAminus -104.35, -161.36 27.53, 84.09 -90.04, 16.15 301.5, 91.82 -59.68, -29.78 in-in in 8.617 Saltbr-in 2.673 HRD-in -85.78, -46.1 64.58, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.82, 162.82 APE9-dihe-na 121.92, 167.13 APE8-dihe-in -72.73, 133.23 APE8-rot-in 298.5 APE67-dihe-in -66.05, -23.0 -49.76, -45.57 APE12-dist-in 8.607 APE11-dist-in 11.905 APE10-dist-in 6.229 APE9-dist-in 3.484 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K1 Homo sapiens AGC_PRKCB_HUMAN AGC 1.1e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN AF-P05771-K3A P05771 334 608 671.0 No_ligand No_ligand Active DFGin 5.745 13.195 BLAminus -110.85, -172.96 35.96, 94.12 -98.35, 13.42 304.83, 99.89 -60.51, -33.43 in-in in 8.348 Saltbr-in 2.666 HRD-in -84.51, -47.08 65.34, 1.87 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.41, 161.65 APE9-dihe-na 129.21, 169.52 APE8-dihe-in -83.16, 130.6 APE8-rot-in 297.23 APE67-dihe-in -58.28, -24.56 -44.92, -51.84 APE12-dist-in 8.731 APE11-dist-in 11.81 APE10-dist-in 6.251 APE9-dist-in 3.357 None None None AF2 -1.0 1.0 1.0 A 275 275 0 0 0 0 [[342, 600]] 1.0 AF-P05771-K3 Homo sapiens AGC_PRKCB_HUMAN AGC 1.1e-98 335.4 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 2I0EB P05771 339 668 671.0 PDS:60902 Type1 Active DFGin 6.906 13.595 BLAminus -122.54, 163.63 74.87, 90.26 -109.7, 30.33 301.59, 90.18 -89.33, 11.84 in-in in 9.025 Saltbr-in 2.821 HRD-in -82.04, -48.12 70.57, -0.74 in-in-in SNCiii in-in ActLoopNT-in 2.947 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.03, 175.5 APE9-dihe-na 106.77, 155.55 APE8-dihe-in -68.48, 122.99 APE8-rot-in 298.97 APE67-dihe-in -65.65, -22.82 -42.1, -37.43 APE12-dist-in 8.683 APE11-dist-in 12.143 APE10-dist-in 6.729 APE9-dist-in 3.821 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.237 0.29 B 353 300 0 0 0 0 [[342, 600]] 1.0 2i0e Homo sapiens AGC_PRKCB_HUMAN AGC 2.7e-98 334.2 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 8SE2A P05771 19 671 671.0 No_ligand No_ligand Inactive DFGin 5.952 13.518 ABAminus -120.86, -65.35 -78.48, 119.96 -110.31, 36.28 298.77, 95.28 -76.53, -5.12 in-in in 8.864 Saltbr-in 2.462 HRD-in -90.7, -48.87 74.08, -6.11 in-in-out SNCiio in-out ActLoopNT-in 3.071 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -164.48, 160.4 APE9-dihe-na 124.42, 177.98 APE8-dihe-in -99.65, 131.7 APE8-rot-out 40.31 APE67-dihe-in -65.28, -24.14 -48.32, -36.09 APE12-dist-in 8.794 APE11-dist-in 11.988 APE10-dist-in 6.578 APE9-dist-in 3.942 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 A 672 599 0 0 0 0 [[342, 600]] 1.0 8se2 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 8SE3A P05771 30 671 671.0 No_ligand No_ligand Inactive DFGin 6.16 13.709 ABAminus -124.07, -33.29 -92.17, 109.74 -116.23, 25.27 297.34, 94.38 -70.45, -20.68 in-in in 8.566 Saltbr-in 2.703 HRD-in -81.86, -43.58 62.11, 4.49 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.91, 179.4 APE9-dihe-na 110.04, -177.12 APE8-dihe-in -93.25, 130.02 APE8-rot-in 297.18 APE67-dihe-in -66.06, -11.73 -57.55, -35.92 APE12-dist-in 8.833 APE11-dist-in 12.028 APE10-dist-in 6.473 APE9-dist-in 3.751 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.199 0.227 A 672 601 0 0 0 0 [[342, 600]] 1.0 8se3 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 8SE4A P05771 19 671 671.0 No_ligand No_ligand Inactive DFGin 6.115 13.438 ABAminus -125.45, -34.56 -87.53, 113.0 -119.18, 39.24 297.28, 94.22 -76.92, -28.17 in-in in 8.425 Saltbr-in 2.542 HRD-in -88.36, -49.83 70.03, 0.79 in-in-in SNCiii in-in ActLoopNT-in 3.102 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.55, 163.91 APE9-dihe-na 116.91, 175.65 APE8-dihe-in -91.2, 128.82 APE8-rot-in 305.77 APE67-dihe-in -67.42, -22.74 -50.74, -31.22 APE12-dist-in 8.712 APE11-dist-in 11.868 APE10-dist-in 6.374 APE9-dist-in 3.878 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 A 672 599 0 0 0 0 [[342, 600]] 1.0 8se4 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 8SE4B P05771 30 671 671.0 ADN:701 Type1 Inactive DFGin 5.738 12.971 ABAminus -126.66, -34.17 -84.97, 112.43 -117.68, 39.4 296.69, 93.7 -74.7, -30.34 in-in in 8.26 Saltbr-in 2.51 HRD-in -88.0, -50.22 70.29, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.54, 164.05 APE9-dihe-na 118.34, -179.99 APE8-dihe-in -91.65, 129.4 APE8-rot-in 306.62 APE67-dihe-in -69.42, -21.97 -51.1, -33.02 APE12-dist-in 8.632 APE11-dist-in 11.783 APE10-dist-in 6.261 APE9-dist-in 3.776 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.68 0.206 0.258 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se4 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 2I0EA P05771 339 668 671.0 PDS:60901 Type1 Inactive DFGin 6.283 13.949 BLAminus -117.76, 167.96 68.91, 88.95 -103.35, 26.8 299.87, 102.06 -70.85, -19.44 in-in in 9.073 Saltbr-in 3.031 HRD-in -81.74, -50.98 74.78, 5.37 in-in-out SNCiio in-out ActLoopNT-in 2.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.38, 168.45 APE9-dihe-na 114.4, 163.6 APE8-dihe-in -94.67, 130.59 APE8-rot-out 93.65 APE67-dihe-in -62.49, -23.91 -28.3, -54.88 APE12-dist-in 9.03 APE11-dist-in 11.905 APE10-dist-in 6.388 APE9-dist-in 4.046 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.6 0.237 0.29 A 353 327 0 0 0 0 [[342, 600]] 1.0 2i0e Homo sapiens AGC_PRKCB_HUMAN AGC 2.7e-98 334.2 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_HUMAN 9S9TA P05771 340 667 671.0 LY4:60701 Type1 Inactive DFGin 6.093 13.973 None -111.78, -89.62 -67.76, 129.93 -115.94, 12.83 282.89, 115.63 -69.35, -46.77 in-in in 8.522 Saltbr-in 2.723 HRD-in -57.71, -56.78 85.18, -40.4 in-in-in SNCiii in-in ActLoopNT-in 3.456 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.66, 131.78 APE9-dihe-na 176.22, -177.75 APE8-dihe-in -90.0, 133.29 APE8-rot-in 321.38 APE67-dihe-in -84.35, -33.13 -46.48, -38.11 APE12-dist-in 8.313 APE11-dist-in 11.686 APE10-dist-in 5.752 APE9-dist-in 4.34 D427N TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.425 0.218 0.29 A 353 315 0 0 0 0 [[342, 600]] 1.0 9s9t Homo sapiens AGC_PRKCB_HUMAN AGC 1.3e-97 332.0 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
KPCB_RAT 3PFQA P68403 101 668 671.0 ANP:60800 ATPlike Inactive DFGin 6.062 13.318 BLAminus -127.91, -175.53 60.89, 88.17 -109.45, 18.93 297.91, 72.76 -66.81, 8.41 in-out in 9.319 Saltbr-out 4.511 HRD-out -53.59, -66.06 65.15, 50.69 out-in-in SNCoii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.97, -178.34 APE9-dihe-na 109.42, -153.48 APE8-dihe-in -112.52, 141.29 APE8-rot-in 328.3 APE67-dihe-in -90.42, -60.35 -50.4, -26.29 APE12-dist-in 8.892 APE11-dist-in 11.964 APE10-dist-in 6.353 APE9-dist-in 4.034 C71S,C217S,R622S TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 4.0 0.244 0.244 A 674 521 0 0 0 0 [[342, 600]] 1.0 3pfq Rattus norvegicus AGC_PRKCB_RAT AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type

AGC_PRKCB (Protein kinase C beta type)

Total number of chains: 1
Active chains: 0
Family: AGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 3PFQA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
KPCB_RAT 3PFQA P68403 101 668 671.0 ANP:60800 ATPlike Inactive DFGin 6.062 13.318 BLAminus -127.91, -175.53 60.89, 88.17 -109.45, 18.93 297.91, 72.76 -66.81, 8.41 in-out in 9.319 Saltbr-out 4.511 HRD-out -53.59, -66.06 65.15, 50.69 out-in-in SNCoii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.97, -178.34 APE9-dihe-na 109.42, -153.48 APE8-dihe-in -112.52, 141.29 APE8-rot-in 328.3 APE67-dihe-in -90.42, -60.35 -50.4, -26.29 APE12-dist-in 8.892 APE11-dist-in 11.964 APE10-dist-in 6.353 APE9-dist-in 4.034 C71S,C217S,R622S TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 4.0 0.244 0.244 A 674 521 0 0 0 0 [[342, 600]] 1.0 3pfq Rattus norvegicus AGC_PRKCB_RAT AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type