OTHER_MLKL (Mixed lineage kinase domain-like protein)

Total number of chains: 15
Active chains: 0
Family: OTHER
Uniprot: MLKL_HUMAN
Kinase Domain Residues: 201 - 468
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 8 53.3% 4MWIA
DFGin BLAplus 3 20.0% 7JXUA
None None 2 13.3% 5KNJB
DFGin BLAminus 1 6.7% 6O5ZA
DFGout None 1 6.7% 6O5ZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
6O5ZA 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.443 14.318 BLAminus -137.01, -155.47 64.86, 62.95 -104.46, 17.08 308.51, 109.01 -69.75, 152.23 in-in in 8.314 Saltbr-in 2.576 HRD-na-E -62.32, -49.91 99.66, -25.44 in-out-out SNCioo out-out ActLoopNT-out 12.971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.47, 131.06 APE9-dihe-na -68.43, 136.41 APE8-dihe-out -55.97, -34.58 APE8-rot-out 73.81 APE67-dihe-in -63.07, -19.3 -55.62, -29.72 APE12-dist-out 15.802 APE11-dist-out 20.901 APE10-dist-out 18.955 APE9-dist-out 13.509 None None None XRAY 2.285 0.188 0.232 A 287 271 9 0 0 9 [[204, 468]] 1.0 6o5z OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
7JXUA 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.233 17.137 BLAplus -132.65, -169.61 81.08, 16.1 -134.12, -7.44 71.35, 105.39 -101.21, 148.73 out-out out 16.392 Saltbr-out 12.623 HRD-na-E -66.65, -47.96 95.71, -27.61 out-out-out SNCooo out-out ActLoopNT-out 12.645 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -121.95, 127.81 APE9-dihe-na -65.07, 143.96 APE8-dihe-out -61.15, -31.11 APE8-rot-out 55.57 APE67-dihe-in -65.35, -21.19 -55.84, -32.25 APE12-dist-out 20.752 APE11-dist-out 23.974 APE10-dist-out 23.051 APE9-dist-out 13.357 None None None XRAY 2.44 0.204 0.24 A 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
7JXUB 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.316 17.087 BLAplus -140.29, -170.33 85.23, 13.17 -130.42, -22.22 65.36, 105.52 -88.31, 149.29 out-out out 16.023 Saltbr-out 12.194 HRD-na-E -66.79, -51.2 109.52, -44.96 out-out-out SNCooo out-out ActLoopNT-out 12.75 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -113.61, 128.79 APE9-dihe-na -66.68, 142.09 APE8-dihe-out -60.09, -31.37 APE8-rot-out 51.22 APE67-dihe-in -64.39, -17.94 -56.16, -31.14 APE12-dist-out 20.441 APE11-dist-out 23.536 APE10-dist-out 22.622 APE9-dist-out 13.679 None None None XRAY 2.44 0.204 0.24 B 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
7MONA 191 469 471.0 ZL1:501 Type1 Pseudo DFGin 9.979 16.865 BLAplus -145.54, -169.15 78.1, 22.67 -139.07, -9.53 71.34, 104.02 -105.01, 150.93 out-out out 16.381 Saltbr-out 13.326 HRD-na-E -68.26, -49.99 100.84, -31.32 out-out-out SNCooo out-out ActLoopNT-out 12.642 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -104.91, 135.41 APE9-dihe-na -71.07, 134.23 APE8-dihe-out -64.44, -25.38 APE8-rot-out 60.07 APE67-dihe-in -61.51, -31.54 -61.49, -26.48 APE12-dist-out 19.855 APE11-dist-out 24.032 APE10-dist-out 23.012 APE9-dist-out 13.36 None None None XRAY 2.23 0.212 0.26 A 287 268 11 0 0 8 [[204, 468]] 1.0 7mon OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
4MWIA 193 470 471.0 PXN:501 Allosteric Pseudo DFGin 5.101 14.027 BLBminus -145.19, 176.51 81.47, 24.62 -54.37, 137.54 316.54, 101.19 -155.24, 156.88 in-in in 8.284 Saltbr-in 2.785 HRD-na-E -64.85, -47.54 108.98, -24.83 in-out-out SNCioo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -117.89, 131.59 APE9-dihe-na -66.57, 138.55 APE8-dihe-out -59.77, -32.75 APE8-rot-in 293.62 APE67-dihe-in -64.78, -27.84 -54.61, -33.19 APE12-dist-out 18.709 APE11-dist-out 22.428 APE10-dist-out 19.559 APE9-dist-out 13.893 None None None XRAY 1.7 0.166 0.194 A 294 266 12 0 0 12 [[204, 468]] 1.0 4mwi OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
6BWKA 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.543 14.506 BLBminus -134.48, -157.9 71.65, 72.71 -113.01, 128.24 304.19, 2.01 -171.84, 999.0 in-none in 8.32 Saltbr-none 999.0 HRD-na-E -70.14, -73.85 121.54, -3.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -50.44, -32.47 APE9-dihe-na -66.22, -37.06 APE8-dihe-out -125.32, 42.89 APE8-rot-in 304.11 APE67-dihe-in -60.02, -24.26 -42.43, -39.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.03 T357E,S358E None None XRAY 2.79 0.257 0.297 A 287 263 16 0 0 16 [[204, 468]] 1.0 6bwk OTHER_MLKL_HUMAN TKL 7.6e-51 179.1 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
7JW7A 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.408 14.242 BLBminus -135.55, -168.18 79.35, 51.65 -93.92, 124.73 313.81, 102.38 -45.2, 999.0 in-in in 8.027 Saltbr-in 3.51 HRD-na-E -77.9, -36.2 97.95, -59.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -51.94 APE9-dihe-na -65.12, 159.46 APE8-dihe-in -56.6, 134.48 APE8-rot-out 181.21 APE67-dihe-in -63.92, -31.38 -109.1, 12.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.171 None None None XRAY 2.63 0.23 0.281 A 287 256 24 0 0 19 [[204, 468]] 1.0 7jw7 OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
8SLZA 191 469 471.0 No_ligand No_ligand Pseudo DFGin 5.233 14.227 BLBminus -150.61, -167.39 68.99, 34.67 -68.29, 133.66 314.13, 95.49 -158.29, 157.94 in-in in 8.235 Saltbr-in 3.271 HRD-na-E -67.15, -50.86 111.36, -33.45 in-out-out SNCioo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -117.52, 132.52 APE9-dihe-na -65.28, 139.38 APE8-dihe-out -65.39, -23.86 APE8-rot-out 181.55 APE67-dihe-in -69.04, -23.74 -66.59, -23.09 APE12-dist-out 21.373 APE11-dist-out 21.61 APE10-dist-out 19.417 APE9-dist-out 14.106 None TPO357,SEP358 TPO357,SEP358 XRAY 2.3 0.204 0.234 A 287 265 14 0 0 14 [[204, 468]] 1.0 8slz OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
4M67A 192 469 471.0 No_ligand No_ligand Pseudo DFGin 5.135 14.327 BLBminus -139.33, 178.33 78.86, 30.59 -63.54, 143.02 316.28, 95.46 -163.25, 152.36 in-in in 8.294 Saltbr-in 2.87 HRD-na-E -69.35, -45.81 105.49, -24.9 in-out-out SNCioo out-out ActLoopNT-out 9.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -114.78, 129.69 APE9-dihe-na -64.48, 137.26 APE8-dihe-out -54.3, -46.25 APE8-rot-out 173.11 APE67-dihe-in -60.1, -29.27 -51.47, -31.0 APE12-dist-out 20.382 APE11-dist-out 22.459 APE10-dist-out 19.663 APE9-dist-out 14.217 None None None XRAY 1.9 0.206 0.225 A 293 264 14 0 0 14 [[204, 468]] 1.0 4m67 OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
6LK6A 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.213 14.238 BLBminus -140.9, -170.14 65.42, 43.61 -73.62, 139.5 313.43, 104.69 -170.25, 149.43 in-in in 8.334 Saltbr-in 2.996 HRD-na-E -65.81, -51.34 97.84, -20.78 in-out-out SNCioo out-out ActLoopNT-out 9.808 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -101.65, 139.93 APE9-dihe-na -76.17, 137.87 APE8-dihe-out -56.28, -33.41 APE8-rot-out 70.42 APE67-dihe-in -50.97, -36.19 -56.07, -45.36 APE12-dist-out 19.515 APE11-dist-out 22.474 APE10-dist-out 19.881 APE9-dist-out 13.826 T357A,S358A None None XRAY 2.41 0.211 0.247 A 293 265 14 0 0 14 [[204, 468]] 1.0 6lk6 OTHER_MLKL_HUMAN TKL 2.7e-50 177.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
6LK5A 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.11 14.286 BLBminus -141.79, -176.2 75.53, 28.55 -58.2, 124.61 313.01, 96.64 -149.56, 158.33 in-in in 8.237 Saltbr-in 3.182 HRD-na-E -64.32, -47.98 104.12, -32.13 in-out-out SNCioo out-out ActLoopNT-out 9.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -108.35, 134.78 APE9-dihe-na -64.51, 142.03 APE8-dihe-out -60.77, -31.01 APE8-rot-out 173.43 APE67-dihe-in -57.88, -30.62 -62.19, -38.79 APE12-dist-out 18.924 APE11-dist-out 22.425 APE10-dist-out 19.628 APE9-dist-out 13.871 T357E,S358D None None XRAY 2.5 0.196 0.238 A 471 265 14 0 0 14 [[204, 468]] 1.0 6lk5 OTHER_MLKL_HUMAN TKL 4e-50 177.2 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
5KO1A 192 470 471.0 6UY:501 Type1 Pseudo DFGin 4.808 14.578 BLBminus -140.42, -174.32 76.63, 35.3 -54.73, 138.73 314.86, 105.28 -152.71, 153.41 in-in in 8.458 Saltbr-in 2.748 HRD-na-E -68.56, -45.64 105.05, -24.44 in-out-out SNCioo out-out ActLoopNT-out 10.017 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -113.74, 135.2 APE9-dihe-na -68.0, 131.39 APE8-dihe-out -57.71, -40.85 APE8-rot-in 266.07 APE67-dihe-in -60.07, -28.3 -49.24, -31.82 APE12-dist-out 19.02 APE11-dist-out 22.517 APE10-dist-out 19.51 APE9-dist-out 14.173 E366A,K367A None None XRAY 2.16 0.19 0.226 A 283 265 14 0 0 14 [[204, 468]] 1.0 5ko1 OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
6O5ZB 190 467 471.0 LN4:501 Type2 Pseudo DFGout 14.831 7.098 None -138.35, -166.14 -159.95, 69.78 -102.91, 999.0 194.77, 99.88 999.0, 999.0 in-out in 8.184 Saltbr-out 3.829 HRD-na-E -64.26, -51.93 98.68, -26.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.03, 132.55 APE9-dihe-na -64.81, 136.14 APE8-dihe-out -54.72, -38.12 APE8-rot-in 307.78 APE67-dihe-in -62.93, -23.04 -55.72, -31.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.392 None None None XRAY 2.285 0.188 0.232 B 287 260 19 0 0 12 [[204, 468]] 1.0 6o5z OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
5KNJA 193 468 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -135.25, 171.18 -163.91, 150.5 -79.14, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.182 Saltbr-in 2.806 HRD-na-E -70.33, -43.91 105.29, -17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -112.22, 131.74 APE9-dihe-na -62.16, 135.85 APE8-dihe-out -59.27, -43.82 APE8-rot-in 300.34 APE67-dihe-in -57.77, -31.82 -42.79, -35.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.573 E366A,K367A None None XRAY 2.88 0.196 0.256 A 283 252 24 0 0 18 [[204, 468]] 1.0 5knj OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
5KNJB 192 469 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -136.96, 165.94 -88.72, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.092 Saltbr-in 2.838 HRD-na-E -70.61, -44.28 104.64, -17.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -135.3, 131.22 APE9-dihe-na -64.5, 137.16 APE8-dihe-out -52.4, -47.35 APE8-rot-in 302.78 APE67-dihe-in -59.21, -30.37 -42.44, -36.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.867 E366A,K367A None None XRAY 2.88 0.196 0.256 B 283 259 19 0 0 19 [[204, 468]] 1.0 5knj OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein

OTHER_MLKL (Mixed lineage kinase domain-like protein)

Total number of chains: 23
Active chains: 0
Family: OTHER
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 13 56.5% 6VC0A
DFGin BLAplus 5 21.7% 7JXUA
None None 3 13.0% 4M69B
DFGin BLAminus 1 4.3% 6O5ZA
DFGout None 1 4.3% 6O5ZB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
F6S337_HORSE 6VC0A F6S337 258 536 543.0 No_ligand No_ligand Pseudo DFGin 4.988 13.881 BLBminus -160.47, -177.36 65.51, 36.37 -58.39, 137.28 318.13, 86.77 58.83, -124.64 in-in in 7.643 Saltbr-in 2.677 HRD-na-E -62.53, -41.81 82.08, -6.9 in-out-out SNCioo out-out ActLoopNT-out 13.362 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -88.0, 120.78 APE9-dihe-na -72.95, 148.97 APE8-dihe-out -64.67, -29.31 APE8-rot-in 286.85 APE67-dihe-in -52.64, -29.19 -53.47, -31.2 APE12-dist-in 12.067 APE11-dist-out 17.622 APE10-dist-out 15.015 APE9-dist-out 13.613 None None None XRAY 2.746 0.175 0.238 A 292 272 7 0 0 7 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
F6S337_HORSE 6VC0B F6S337 258 537 543.0 No_ligand No_ligand Pseudo DFGin 5.138 14.211 BLBminus -147.23, -169.43 57.25, 44.02 -61.21, 135.2 309.04, 84.31 57.69, -129.98 in-in in 7.975 Saltbr-in 3.151 HRD-na-E -65.25, -45.35 82.07, -9.74 in-out-out SNCioo out-out ActLoopNT-out 13.481 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -126.45, 116.02 APE9-dihe-na -51.25, 124.58 APE8-dihe-out -50.77, -33.76 APE8-rot-in 297.7 APE67-dihe-in -54.8, -30.44 -56.98, -22.96 APE12-dist-none 999.0 APE11-dist-out 16.172 APE10-dist-out 15.204 APE9-dist-out 13.714 None None None XRAY 2.746 0.175 0.238 B 292 269 11 0 0 11 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
F6S337_HORSE 6VC0C F6S337 258 541 543.0 No_ligand No_ligand Pseudo DFGin 5.403 14.135 BLBminus -139.49, -162.99 63.64, 39.99 -70.44, 152.53 306.23, 102.18 57.77, 37.75 in-in in 7.883 Saltbr-in 2.77 HRD-na-E -65.22, -39.62 76.85, -6.27 in-out-out SNCioo out-out ActLoopNT-out 13.68 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.28, 135.92 APE9-dihe-na -86.15, 145.34 APE8-dihe-out -56.36, -39.87 APE8-rot-in 295.41 APE67-dihe-in -54.7, -29.08 -59.22, -20.61 APE12-dist-in 12.868 APE11-dist-out 17.817 APE10-dist-out 15.143 APE9-dist-out 13.226 None None None XRAY 2.746 0.175 0.238 C 292 271 13 0 0 8 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
MLKL_HUMAN 6O5ZA Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.443 14.318 BLAminus -137.01, -155.47 64.86, 62.95 -104.46, 17.08 308.51, 109.01 -69.75, 152.23 in-in in 8.314 Saltbr-in 2.576 HRD-na-E -62.32, -49.91 99.66, -25.44 in-out-out SNCioo out-out ActLoopNT-out 12.971 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -58.47, 131.06 APE9-dihe-na -68.43, 136.41 APE8-dihe-out -55.97, -34.58 APE8-rot-out 73.81 APE67-dihe-in -63.07, -19.3 -55.62, -29.72 APE12-dist-out 15.802 APE11-dist-out 20.901 APE10-dist-out 18.955 APE9-dist-out 13.509 None None None XRAY 2.285 0.188 0.232 A 287 271 9 0 0 9 [[204, 468]] 1.0 6o5z Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 7JXUA Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.233 17.137 BLAplus -132.65, -169.61 81.08, 16.1 -134.12, -7.44 71.35, 105.39 -101.21, 148.73 out-out out 16.392 Saltbr-out 12.623 HRD-na-E -66.65, -47.96 95.71, -27.61 out-out-out SNCooo out-out ActLoopNT-out 12.645 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -121.95, 127.81 APE9-dihe-na -65.07, 143.96 APE8-dihe-out -61.15, -31.11 APE8-rot-out 55.57 APE67-dihe-in -65.35, -21.19 -55.84, -32.25 APE12-dist-out 20.752 APE11-dist-out 23.974 APE10-dist-out 23.051 APE9-dist-out 13.357 None None None XRAY 2.44 0.204 0.24 A 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 7JXUB Q8NB16 191 471 471.0 No_ligand No_ligand Pseudo DFGin 10.316 17.087 BLAplus -140.29, -170.33 85.23, 13.17 -130.42, -22.22 65.36, 105.52 -88.31, 149.29 out-out out 16.023 Saltbr-out 12.194 HRD-na-E -66.79, -51.2 109.52, -44.96 out-out-out SNCooo out-out ActLoopNT-out 12.75 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -113.61, 128.79 APE9-dihe-na -66.68, 142.09 APE8-dihe-out -60.09, -31.37 APE8-rot-out 51.22 APE67-dihe-in -64.39, -17.94 -56.16, -31.14 APE12-dist-out 20.441 APE11-dist-out 23.536 APE10-dist-out 22.622 APE9-dist-out 13.679 None None None XRAY 2.44 0.204 0.24 B 287 281 0 0 0 0 [[204, 468]] 1.0 7jxu Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 7MONA Q8NB16 191 469 471.0 ZL1:501 Type1 Pseudo DFGin 9.979 16.865 BLAplus -145.54, -169.15 78.1, 22.67 -139.07, -9.53 71.34, 104.02 -105.01, 150.93 out-out out 16.381 Saltbr-out 13.326 HRD-na-E -68.26, -49.99 100.84, -31.32 out-out-out SNCooo out-out ActLoopNT-out 12.642 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -104.91, 135.41 APE9-dihe-na -71.07, 134.23 APE8-dihe-out -64.44, -25.38 APE8-rot-out 60.07 APE67-dihe-in -61.51, -31.54 -61.49, -26.48 APE12-dist-out 19.855 APE11-dist-out 24.032 APE10-dist-out 23.012 APE9-dist-out 13.36 None None None XRAY 2.23 0.212 0.26 A 287 268 11 0 0 8 [[204, 468]] 1.0 7mon Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 4MWIA Q8NB16 193 470 471.0 PXN:501 Allosteric Pseudo DFGin 5.101 14.027 BLBminus -145.19, 176.51 81.47, 24.62 -54.37, 137.54 316.54, 101.19 -155.24, 156.88 in-in in 8.284 Saltbr-in 2.785 HRD-na-E -64.85, -47.54 108.98, -24.83 in-out-out SNCioo out-out ActLoopNT-out 9.848 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -117.89, 131.59 APE9-dihe-na -66.57, 138.55 APE8-dihe-out -59.77, -32.75 APE8-rot-in 293.62 APE67-dihe-in -64.78, -27.84 -54.61, -33.19 APE12-dist-out 18.709 APE11-dist-out 22.428 APE10-dist-out 19.559 APE9-dist-out 13.893 None None None XRAY 1.7 0.166 0.194 A 294 266 12 0 0 12 [[204, 468]] 1.0 4mwi Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 6BWKA Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.543 14.506 BLBminus -134.48, -157.9 71.65, 72.71 -113.01, 128.24 304.19, 2.01 -171.84, 999.0 in-none in 8.32 Saltbr-none 999.0 HRD-na-E -70.14, -73.85 121.54, -3.94 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -50.44, -32.47 APE9-dihe-na -66.22, -37.06 APE8-dihe-out -125.32, 42.89 APE8-rot-in 304.11 APE67-dihe-in -60.02, -24.26 -42.43, -39.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.03 T357E,S358E None None XRAY 2.79 0.257 0.297 A 287 263 16 0 0 16 [[204, 468]] 1.0 6bwk Homo sapiens OTHER_MLKL_HUMAN TKL 7.6e-51 179.1 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 7JW7A Q8NB16 191 470 471.0 No_ligand No_ligand Pseudo DFGin 5.408 14.242 BLBminus -135.55, -168.18 79.35, 51.65 -93.92, 124.73 313.81, 102.38 -45.2, 999.0 in-in in 8.027 Saltbr-in 3.51 HRD-na-E -77.9, -36.2 97.95, -59.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, -51.94 APE9-dihe-na -65.12, 159.46 APE8-dihe-in -56.6, 134.48 APE8-rot-out 181.21 APE67-dihe-in -63.92, -31.38 -109.1, 12.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.171 None None None XRAY 2.63 0.23 0.281 A 287 256 24 0 0 19 [[204, 468]] 1.0 7jw7 Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 8SLZA Q8NB16 191 469 471.0 No_ligand No_ligand Pseudo DFGin 5.233 14.227 BLBminus -150.61, -167.39 68.99, 34.67 -68.29, 133.66 314.13, 95.49 -158.29, 157.94 in-in in 8.235 Saltbr-in 3.271 HRD-na-E -67.15, -50.86 111.36, -33.45 in-out-out SNCioo out-out ActLoopNT-out 10.041 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -117.52, 132.52 APE9-dihe-na -65.28, 139.38 APE8-dihe-out -65.39, -23.86 APE8-rot-out 181.55 APE67-dihe-in -69.04, -23.74 -66.59, -23.09 APE12-dist-out 21.373 APE11-dist-out 21.61 APE10-dist-out 19.417 APE9-dist-out 14.106 None TPO357,SEP358 TPO357,SEP358 XRAY 2.3 0.204 0.234 A 287 265 14 0 0 14 [[204, 468]] 1.0 8slz Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 4M67A Q8NB16 192 469 471.0 No_ligand No_ligand Pseudo DFGin 5.135 14.327 BLBminus -139.33, 178.33 78.86, 30.59 -63.54, 143.02 316.28, 95.46 -163.25, 152.36 in-in in 8.294 Saltbr-in 2.87 HRD-na-E -69.35, -45.81 105.49, -24.9 in-out-out SNCioo out-out ActLoopNT-out 9.945 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -114.78, 129.69 APE9-dihe-na -64.48, 137.26 APE8-dihe-out -54.3, -46.25 APE8-rot-out 173.11 APE67-dihe-in -60.1, -29.27 -51.47, -31.0 APE12-dist-out 20.382 APE11-dist-out 22.459 APE10-dist-out 19.663 APE9-dist-out 14.217 None None None XRAY 1.9 0.206 0.225 A 293 264 14 0 0 14 [[204, 468]] 1.0 4m67 Homo sapiens OTHER_MLKL_HUMAN TKL 1.3e-50 178.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 6LK6A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.213 14.238 BLBminus -140.9, -170.14 65.42, 43.61 -73.62, 139.5 313.43, 104.69 -170.25, 149.43 in-in in 8.334 Saltbr-in 2.996 HRD-na-E -65.81, -51.34 97.84, -20.78 in-out-out SNCioo out-out ActLoopNT-out 9.808 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -101.65, 139.93 APE9-dihe-na -76.17, 137.87 APE8-dihe-out -56.28, -33.41 APE8-rot-out 70.42 APE67-dihe-in -50.97, -36.19 -56.07, -45.36 APE12-dist-out 19.515 APE11-dist-out 22.474 APE10-dist-out 19.881 APE9-dist-out 13.826 T357A,S358A None None XRAY 2.41 0.211 0.247 A 293 265 14 0 0 14 [[204, 468]] 1.0 6lk6 Homo sapiens OTHER_MLKL_HUMAN TKL 2.7e-50 177.3 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 6LK5A Q8NB16 192 470 471.0 No_ligand No_ligand Pseudo DFGin 5.11 14.286 BLBminus -141.79, -176.2 75.53, 28.55 -58.2, 124.61 313.01, 96.64 -149.56, 158.33 in-in in 8.237 Saltbr-in 3.182 HRD-na-E -64.32, -47.98 104.12, -32.13 in-out-out SNCioo out-out ActLoopNT-out 9.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -108.35, 134.78 APE9-dihe-na -64.51, 142.03 APE8-dihe-out -60.77, -31.01 APE8-rot-out 173.43 APE67-dihe-in -57.88, -30.62 -62.19, -38.79 APE12-dist-out 18.924 APE11-dist-out 22.425 APE10-dist-out 19.628 APE9-dist-out 13.871 T357E,S358D None None XRAY 2.5 0.196 0.238 A 471 265 14 0 0 14 [[204, 468]] 1.0 6lk5 Homo sapiens OTHER_MLKL_HUMAN TKL 4e-50 177.2 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 5KO1A Q8NB16 192 470 471.0 6UY:501 Type1 Pseudo DFGin 4.808 14.578 BLBminus -140.42, -174.32 76.63, 35.3 -54.73, 138.73 314.86, 105.28 -152.71, 153.41 in-in in 8.458 Saltbr-in 2.748 HRD-na-E -68.56, -45.64 105.05, -24.44 in-out-out SNCioo out-out ActLoopNT-out 10.017 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -113.74, 135.2 APE9-dihe-na -68.0, 131.39 APE8-dihe-out -57.71, -40.85 APE8-rot-in 266.07 APE67-dihe-in -60.07, -28.3 -49.24, -31.82 APE12-dist-out 19.02 APE11-dist-out 22.517 APE10-dist-out 19.51 APE9-dist-out 14.173 E366A,K367A None None XRAY 2.16 0.19 0.226 A 283 265 14 0 0 14 [[204, 468]] 1.0 5ko1 Homo sapiens OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 6O5ZB Q8NB16 190 467 471.0 LN4:501 Type2 Pseudo DFGout 14.831 7.098 None -138.35, -166.14 -159.95, 69.78 -102.91, 999.0 194.77, 99.88 999.0, 999.0 in-out in 8.184 Saltbr-out 3.829 HRD-na-E -64.26, -51.93 98.68, -26.13 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -59.03, 132.55 APE9-dihe-na -64.81, 136.14 APE8-dihe-out -54.72, -38.12 APE8-rot-in 307.78 APE67-dihe-in -62.93, -23.04 -55.72, -31.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.392 None None None XRAY 2.285 0.188 0.232 B 287 260 19 0 0 12 [[204, 468]] 1.0 6o5z Homo sapiens OTHER_MLKL_HUMAN TKL 1.2e-50 178.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 5KNJA Q8NB16 193 468 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -135.25, 171.18 -163.91, 150.5 -79.14, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.182 Saltbr-in 2.806 HRD-na-E -70.33, -43.91 105.29, -17.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -112.22, 131.74 APE9-dihe-na -62.16, 135.85 APE8-dihe-out -59.27, -43.82 APE8-rot-in 300.34 APE67-dihe-in -57.77, -31.82 -42.79, -35.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.573 E366A,K367A None None XRAY 2.88 0.196 0.256 A 283 252 24 0 0 18 [[204, 468]] 1.0 5knj Homo sapiens OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_HUMAN 5KNJB Q8NB16 192 469 471.0 6UX:501 Type1 Pseudo None 999.0 999.0 None -136.96, 165.94 -88.72, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 8.092 Saltbr-in 2.838 HRD-na-E -70.61, -44.28 104.64, -17.59 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na -135.3, 131.22 APE9-dihe-na -64.5, 137.16 APE8-dihe-out -52.4, -47.35 APE8-rot-in 302.78 APE67-dihe-in -59.21, -30.37 -42.44, -36.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.867 E366A,K367A None None XRAY 2.88 0.196 0.256 B 283 259 19 0 0 19 [[204, 468]] 1.0 5knj Homo sapiens OTHER_MLKL_HUMAN TKL 5.2e-50 176.4 7 266 260 348 349 350 352 354 230 250 254 328 330 329 331 394 380 375 374 373 372 371 370 369 284 Mixed lineage kinase domain-like protein
MLKL_MOUSE 4M68A Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo DFGin 9.852 16.7 BLAplus -129.7, -163.13 77.79, 17.7 -134.64, -18.09 73.34, 102.06 -94.56, 159.05 out-out out 16.505 Saltbr-out 13.3 HRD-na-E -69.29, -48.17 86.0, -11.45 out-out-out SNCooo out-out ActLoopNT-out 11.888 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 128.37 APE9-dihe-na -54.91, -21.63 APE8-dihe-out -63.15, -25.67 APE8-rot-out 40.6 APE67-dihe-in -52.68, -39.76 -124.73, 3.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 25.824 APE9-dist-out 12.948 None None None XRAY 1.696 0.195 0.216 A 283 268 9 0 0 9 [[189, 451]] 1.0 4m68 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
MLKL_MOUSE 4BTFA Q9D2Y4 2 463 472.0 No_ligand No_ligand Pseudo DFGin 9.681 16.7 BLAplus -133.91, -159.82 79.78, 12.69 -135.05, -21.42 69.63, 92.26 -89.6, 153.33 out-out out 16.15 Saltbr-out 11.221 HRD-na-E -72.28, -47.25 76.21, -2.88 out-out-out SNCooo out-out ActLoopNT-out 12.025 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.4 APE8-dihe-out -103.41, -28.46 APE8-rot-in 243.61 APE67-dihe-in -72.27, -11.5 -56.76, -28.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4 None None None XRAY 2.604 0.209 0.256 A 469 413 8 0 0 8 [[189, 451]] 1.0 4btf Mus musculus OTHER_MLKL_MOUSE TKL 1e-47 169.7 6 266 261 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
MLKL_MOUSE 4M69B Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo None 14.113 18.823 None -93.73, 159.62 -63.02, 163.0 -50.35, -54.58 169.88, 78.24 -71.37, -37.09 out-out out 13.469 Saltbr-out 9.651 HRD-na-E -74.43, -45.05 83.78, -5.4 out-out-out SNCooo out-out ActLoopNT-out 12.232 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 7.21 APE9-dihe-na -94.48, 162.52 APE8-dihe-out -72.69, -20.09 APE8-rot-in 348.33 APE67-dihe-in -64.41, -24.19 -65.78, -12.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.954 APE9-dist-out 14.179 None None None XRAY 2.497 0.222 0.246 B 283 264 13 0 0 13 [[189, 451]] 1.0 4m69 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
D3ZKP6_RAT 6VBZA D3ZKP6 183 454 462.0 No_ligand No_ligand Pseudo DFGin 5.806 14.618 BLBminus -127.94, -150.16 82.3, 7.23 -50.29, 129.54 298.11, 127.33 -134.6, 159.72 in-in in 8.01 Saltbr-in 2.839 HRD-na-E -66.14, -44.04 96.84, -17.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -117.57, 160.85 APE9-dihe-na -74.63, 135.58 APE8-dihe-out -62.94, -16.08 APE8-rot-out 71.09 APE67-dihe-in -56.49, -25.33 -62.02, -19.84 APE12-dist-none 999.0 APE11-dist-out 22.777 APE10-dist-out 23.132 APE9-dist-out 14.696 None None None XRAY 2.192 0.184 0.215 A 295 256 16 0 0 16 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
D3ZKP6_RAT 6VBZB D3ZKP6 182 454 462.0 No_ligand No_ligand Pseudo DFGin 6.646 15.8 BLBminus -133.61, 172.11 77.91, 57.02 -87.12, 172.28 304.15, 97.39 -154.58, -167.67 in-in in 7.826 Saltbr-in 2.43 HRD-na-E -68.53, -47.34 101.45, -26.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -138.28, 162.06 APE9-dihe-na -77.74, 131.79 APE8-dihe-out -67.86, -11.53 APE8-rot-out 53.7 APE67-dihe-in -52.65, -30.9 -54.76, -23.09 APE12-dist-none 999.0 APE11-dist-out 27.324 APE10-dist-out 24.958 APE9-dist-out 14.833 None None None XRAY 2.192 0.184 0.215 B 295 256 17 0 0 17 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein

OTHER_MLKL (Mixed lineage kinase domain-like protein)

Total number of chains: 8
Active chains: 0
Family: OTHER
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 5 62.5% 6VC0A
DFGin BLAplus 2 25.0% 4BTFA
None None 1 12.5% 4M69B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
F6S337_HORSE 6VC0A F6S337 258 536 543.0 No_ligand No_ligand Pseudo DFGin 4.988 13.881 BLBminus -160.47, -177.36 65.51, 36.37 -58.39, 137.28 318.13, 86.77 58.83, -124.64 in-in in 7.643 Saltbr-in 2.677 HRD-na-E -62.53, -41.81 82.08, -6.9 in-out-out SNCioo out-out ActLoopNT-out 13.362 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -88.0, 120.78 APE9-dihe-na -72.95, 148.97 APE8-dihe-out -64.67, -29.31 APE8-rot-in 286.85 APE67-dihe-in -52.64, -29.19 -53.47, -31.2 APE12-dist-in 12.067 APE11-dist-out 17.622 APE10-dist-out 15.015 APE9-dist-out 13.613 None None None XRAY 2.746 0.175 0.238 A 292 272 7 0 0 7 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
F6S337_HORSE 6VC0B F6S337 258 537 543.0 No_ligand No_ligand Pseudo DFGin 5.138 14.211 BLBminus -147.23, -169.43 57.25, 44.02 -61.21, 135.2 309.04, 84.31 57.69, -129.98 in-in in 7.975 Saltbr-in 3.151 HRD-na-E -65.25, -45.35 82.07, -9.74 in-out-out SNCioo out-out ActLoopNT-out 13.481 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -126.45, 116.02 APE9-dihe-na -51.25, 124.58 APE8-dihe-out -50.77, -33.76 APE8-rot-in 297.7 APE67-dihe-in -54.8, -30.44 -56.98, -22.96 APE12-dist-none 999.0 APE11-dist-out 16.172 APE10-dist-out 15.204 APE9-dist-out 13.714 None None None XRAY 2.746 0.175 0.238 B 292 269 11 0 0 11 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
F6S337_HORSE 6VC0C F6S337 258 541 543.0 No_ligand No_ligand Pseudo DFGin 5.403 14.135 BLBminus -139.49, -162.99 63.64, 39.99 -70.44, 152.53 306.23, 102.18 57.77, 37.75 in-in in 7.883 Saltbr-in 2.77 HRD-na-E -65.22, -39.62 76.85, -6.27 in-out-out SNCioo out-out ActLoopNT-out 13.68 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -63.28, 135.92 APE9-dihe-na -86.15, 145.34 APE8-dihe-out -56.36, -39.87 APE8-rot-in 295.41 APE67-dihe-in -54.7, -29.08 -59.22, -20.61 APE12-dist-in 12.868 APE11-dist-out 17.817 APE10-dist-out 15.143 APE9-dist-out 13.226 None None None XRAY 2.746 0.175 0.238 C 292 271 13 0 0 8 [[272, 535]] 1.0 6vc0 Equus caballus OTHER_MLKL_HORSE TKL 2.5e-50 177.4 7 266 260 415 416 417 419 421 296 316 320 395 397 396 398 461 447 442 441 440 439 438 437 436 350 Mixed lineage kinase domain like pseudokinase
MLKL_MOUSE 4M68A Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo DFGin 9.852 16.7 BLAplus -129.7, -163.13 77.79, 17.7 -134.64, -18.09 73.34, 102.06 -94.56, 159.05 out-out out 16.505 Saltbr-out 13.3 HRD-na-E -69.29, -48.17 86.0, -11.45 out-out-out SNCooo out-out ActLoopNT-out 11.888 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 128.37 APE9-dihe-na -54.91, -21.63 APE8-dihe-out -63.15, -25.67 APE8-rot-out 40.6 APE67-dihe-in -52.68, -39.76 -124.73, 3.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 25.824 APE9-dist-out 12.948 None None None XRAY 1.696 0.195 0.216 A 283 268 9 0 0 9 [[189, 451]] 1.0 4m68 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
MLKL_MOUSE 4BTFA Q9D2Y4 2 463 472.0 No_ligand No_ligand Pseudo DFGin 9.681 16.7 BLAplus -133.91, -159.82 79.78, 12.69 -135.05, -21.42 69.63, 92.26 -89.6, 153.33 out-out out 16.15 Saltbr-out 11.221 HRD-na-E -72.28, -47.25 76.21, -2.88 out-out-out SNCooo out-out ActLoopNT-out 12.025 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.4 APE8-dihe-out -103.41, -28.46 APE8-rot-in 243.61 APE67-dihe-in -72.27, -11.5 -56.76, -28.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.4 None None None XRAY 2.604 0.209 0.256 A 469 413 8 0 0 8 [[189, 451]] 1.0 4btf Mus musculus OTHER_MLKL_MOUSE TKL 1e-47 169.7 6 266 261 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
MLKL_MOUSE 4M69B Q9D2Y4 182 466 472.0 No_ligand No_ligand Pseudo None 14.113 18.823 None -93.73, 159.62 -63.02, 163.0 -50.35, -54.58 169.88, 78.24 -71.37, -37.09 out-out out 13.469 Saltbr-out 9.651 HRD-na-E -74.43, -45.05 83.78, -5.4 out-out-out SNCooo out-out ActLoopNT-out 12.232 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 7.21 APE9-dihe-na -94.48, 162.52 APE8-dihe-out -72.69, -20.09 APE8-rot-in 348.33 APE67-dihe-in -64.41, -24.19 -65.78, -12.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.954 APE9-dist-out 14.179 None None None XRAY 2.497 0.222 0.246 B 283 264 13 0 0 13 [[189, 451]] 1.0 4m69 Mus musculus OTHER_MLKL_MOUSE TKL 2.1e-48 171.1 7 266 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
D3ZKP6_RAT 6VBZA D3ZKP6 183 454 462.0 No_ligand No_ligand Pseudo DFGin 5.806 14.618 BLBminus -127.94, -150.16 82.3, 7.23 -50.29, 129.54 298.11, 127.33 -134.6, 159.72 in-in in 8.01 Saltbr-in 2.839 HRD-na-E -66.14, -44.04 96.84, -17.36 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -117.57, 160.85 APE9-dihe-na -74.63, 135.58 APE8-dihe-out -62.94, -16.08 APE8-rot-out 71.09 APE67-dihe-in -56.49, -25.33 -62.02, -19.84 APE12-dist-none 999.0 APE11-dist-out 22.777 APE10-dist-out 23.132 APE9-dist-out 14.696 None None None XRAY 2.192 0.184 0.215 A 295 256 16 0 0 16 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein
D3ZKP6_RAT 6VBZB D3ZKP6 182 454 462.0 No_ligand No_ligand Pseudo DFGin 6.646 15.8 BLBminus -133.61, 172.11 77.91, 57.02 -87.12, 172.28 304.15, 97.39 -154.58, -167.67 in-in in 7.826 Saltbr-in 2.43 HRD-na-E -68.53, -47.34 101.45, -26.64 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -138.28, 162.06 APE9-dihe-na -77.74, 131.79 APE8-dihe-out -67.86, -11.53 APE8-rot-out 53.7 APE67-dihe-in -52.65, -30.9 -54.76, -23.09 APE12-dist-none 999.0 APE11-dist-out 27.324 APE10-dist-out 24.958 APE9-dist-out 14.833 None None None XRAY 2.192 0.184 0.215 B 295 256 17 0 0 17 [[190, 454]] 1.0 6vbz Rattus norvegicus OTHER_MLKL_RAT TKL 1.7e-47 168.1 6 265 260 335 336 337 339 341 219 239 243 315 317 316 318 381 367 362 361 360 359 358 357 356 273 Mixed lineage kinase domain-like protein