CAMK_MELK (Maternal embryonic leucine zipper kinase)

Total number of chains: 53
Active chains: 2
Uniprot: MELK_HUMAN
Kinase Domain Residues: 11 - 263
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 41 77.4% AF-Q14680-K1A
None None 3 5.7% 6VXRA
DFGin ABAminus 2 3.8% 4BL1A
DFGin None 2 3.8% 5MAIA
DFGinter None 2 3.8% 4UMTA
DFGin BLBminus 1 1.9% 5IHCA
DFGinter BABtrans 1 1.9% 4IXPA
DFGout None 1 1.9% 5K00A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MELK AF-Q14680-K1A Q14680 3 271 651.0 No_ligand No_ligand Active DFGin 6.6628 14.8519 BLAminus -121.05, -178.94 55.54, 67.09 -78.42, 16.52 286.9, 79.58 -60.33, -23.28 in-in in 9.3046 Saltbr-in 2.7248 HRD-in -75.84, -50.36 66.57, 14.62 in-in-in SNCiii in-in ActLoopNT-in 3.0165 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 166.92 APE9-dihe-na 98.89, 172.09 APE8-dihe-in -67.52, 132.67 APE8-rot-in 286.83 APE67-dihe-in -68.01, -21.76 -55.55, -41.05 APE12-dist-in 8.6652 APE11-dist-in 11.2938 APE10-dist-in 5.6748 APE9-dist-in 3.779 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 29 29 0 [[11, 263]] 1.0 AF-Q14680-K1 CAMK_MELK_HUMAN CAMK 4.4e-89 304.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK AF-Q14680-K3A Q14680 3 271 651.0 No_ligand No_ligand Active DFGin 6.498 14.8248 BLAminus -123.1, -178.85 53.35, 68.52 -77.81, 16.02 289.31, 78.98 -63.89, -14.25 in-in in 9.2137 Saltbr-in 2.7053 HRD-in -77.78, -49.26 68.33, 6.33 in-in-in SNCiii in-in ActLoopNT-in 2.9112 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.84, 171.36 APE9-dihe-na 95.07, 170.83 APE8-dihe-in -65.23, 128.46 APE8-rot-in 280.71 APE67-dihe-in -62.2, -18.93 -58.85, -41.82 APE12-dist-in 8.6445 APE11-dist-in 11.6067 APE10-dist-in 6.0114 APE9-dist-in 3.5359 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 29 29 0 [[11, 263]] 1.0 AF-Q14680-K3 CAMK_MELK_HUMAN CAMK 4.4e-89 304.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4BL1A Q14680 2 333 651.0 ANP:1000 ATPlike Inactive DFGin 6.3379 13.9347 ABAminus -114.35, -16.21 -125.02, 95.86 -105.85, 20.97 306.05, 72.32 -48.23, -28.35 in-in in 8.5656 Saltbr-in 2.6282 HRD-in -47.49, -61.71 83.33, 5.93 in-in-out SNCiio in-out ActLoopNT-in 3.0985 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.09 APE8-rot-out 166.93 APE67-dihe-in -51.79, -28.37 -37.56, -42.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.184 0.26 A 347.0 312.0 20 29 15 14 [[11, 263]] 1.0 4bl1 CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TX3A Q14680 1 333 651.0 7MY:61000 Type1 Inactive DFGin 6.7086 15.7403 ABAminus -129.52, -56.19 -85.52, 113.68 -108.84, 24.42 293.03, 74.98 -57.98, -30.68 out-out out 11.7923 Saltbr-out 8.8638 HRD-in -62.75, -40.48 54.82, 17.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -113.41 APE8-dihe-in -87.51, 145.06 APE8-rot-out 167.33 APE67-dihe-in -59.02, -7.95 -81.22, -43.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.4199 None None None XRAY 2.9 0.189 0.253 A 344.0 303.0 30 29 13 16 [[11, 263]] 1.0 5tx3 CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TWUA Q14680 1 333 651.0 No_ligand No_ligand Inactive DFGin 6.6969 15.6536 BLAminus -129.99, 179.95 65.09, 74.8 -95.36, 28.06 283.61, 75.01 -65.09, -29.27 in-in in 9.194 Saltbr-in 3.056 HRD-in -69.34, -46.52 71.86, 4.44 in-in-out SNCiio in-out ActLoopNT-in 2.7968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.41 APE8-dihe-in -91.14, 149.5 APE8-rot-out 65.84 APE67-dihe-in -55.13, -22.29 -65.51, -45.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9215 None None None XRAY 2.603 0.167 0.235 A 344.0 315.0 18 29 22 7 [[11, 263]] 1.0 5twu CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TWUB Q14680 1 335 651.0 No_ligand No_ligand Inactive DFGin 6.5668 15.9032 BLAminus -128.11, -176.85 63.36, 72.51 -97.13, 27.9 284.98, 79.21 -66.22, -30.22 in-in in 9.5403 Saltbr-in 2.9284 HRD-in -67.9, -46.44 71.63, 6.08 in-in-out SNCiio in-out ActLoopNT-in 3.0712 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 86.14 APE9-dihe-na -79.32, -138.67 APE8-dihe-in -88.52, 146.37 APE8-rot-out 63.54 APE67-dihe-in -55.93, -22.54 -67.27, -45.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.0414 APE9-dist-in 3.8369 None None None XRAY 2.603 0.167 0.235 B 344.0 311.0 24 29 17 12 [[11, 263]] 1.0 5twu CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TWZA Q14680 2 333 651.0 45R:61000 Type1 Inactive DFGin 6.0558 15.1103 BLAminus -135.13, 175.3 50.67, 77.34 -80.78, 119.22 288.77, 77.67 -133.08, 999.0 out-none out 11.9674 Saltbr-none 999.0 HRD-in -71.45, -42.53 66.57, 4.79 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 113.11 APE8-dihe-in -104.75, 96.77 APE8-rot-out 175.45 APE67-dihe-in -67.58, -11.75 -76.23, -35.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.3243 None None None XRAY 2.631 0.223 0.259 A 341.0 312.0 20 29 12 17 [[11, 263]] 1.0 5twz CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 6GVXB Q14680 1 335 651.0 TAK:60402 Type1 Inactive DFGin 6.7539 15.4942 BLAminus -124.69, 179.93 57.83, 81.5 -101.39, 28.11 283.05, 78.99 -70.11, -31.83 in-in in 9.0647 Saltbr-in 2.472 HRD-in -64.06, -46.18 61.47, 17.03 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -127.94 APE8-dihe-in -66.05, 131.75 APE8-rot-out 178.58 APE67-dihe-in -65.84, -20.47 -62.83, -40.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.407 None None None XRAY 2.24 0.205 0.24 B 344.0 315.0 20 29 17 12 [[11, 263]] 1.0 6gvx CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4BKZA Q14680 2 334 651.0 1WS:1335 Type1 Inactive DFGin 6.6847 14.9959 BLAminus -122.33, 174.76 61.2, 76.56 -93.17, 28.31 293.04, 71.56 -72.57, -28.75 in-in in 9.3324 Saltbr-in 2.9998 HRD-in -72.3, -44.46 69.02, -4.23 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -17.58 APE8-rot-out 93.23 APE67-dihe-in -45.75, -36.65 -58.97, -41.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.201 0.24 A 347.0 309.0 24 29 14 15 [[11, 263]] 1.0 4bkz CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5M5AA Q14680 2 333 651.0 KSA:404 Type1 Inactive DFGin 6.5676 14.3671 BLAminus -128.52, 174.95 69.66, 80.58 -99.26, 20.16 288.02, 75.17 -59.14, -23.43 in-in in 9.7218 Saltbr-in 2.6179 HRD-in -77.9, -54.21 76.42, -2.14 in-in-out SNCiio in-out ActLoopNT-in 2.9942 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -68.55 APE8-rot-out 186.58 APE67-dihe-in -58.12, -27.37 -53.28, -41.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.187 0.214 A 347.0 315.0 17 29 14 15 [[11, 263]] 1.0 5m5a CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5MAGA Q14680 3 335 651.0 7KC:401 Type1 Inactive DFGin 6.6918 14.9869 BLAminus -126.92, 174.57 68.63, 74.58 -97.26, 21.55 288.43, 79.18 -64.62, -40.12 in-in in 9.0518 Saltbr-in 2.8291 HRD-in -73.74, -51.64 77.77, -11.12 in-in-out SNCiio in-out ActLoopNT-in 3.007 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.12 APE8-rot-out 175.02 APE67-dihe-in -58.72, -25.6 -61.09, -40.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.196 0.252 A 347.0 314.0 19 29 15 14 [[11, 263]] 1.0 5mag CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5MAHA Q14680 2 333 651.0 7KD:401 Type1 Inactive DFGin 6.8254 14.4815 BLAminus -125.71, 172.04 69.81, 78.26 -96.5, 20.96 290.79, 71.84 -62.8, -27.67 in-in in 8.5728 Saltbr-in 2.6261 HRD-in -72.24, -51.67 74.84, 2.35 in-in-out SNCiio in-out ActLoopNT-in 2.8845 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -55.15 APE8-rot-out 194.61 APE67-dihe-in -57.26, -25.97 -56.03, -40.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.185 0.237 A 347.0 316.0 16 29 15 14 [[11, 263]] 1.0 5mah CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 9F31A Q14680 1 335 651.0 A1H9M:401 Type1 Inactive DFGin 7.4487 14.5944 BLAminus -119.6, 170.59 71.52, 65.71 -71.15, -65.91 280.26, 79.82 -135.18, -136.64 out-out out 11.3729 Saltbr-out 7.3243 HRD-in -90.64, -49.21 79.03, -5.96 out-out-out SNCooo out-out ActLoopNT-out 12.603 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -26.08 APE8-rot-out 185.8 APE67-dihe-in -60.0, -24.89 -65.19, -21.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.191 0.233 A 349.0 320.0 15 29 14 15 [[11, 263]] 1.0 9f31 CAMK_MELK_HUMAN CAMK 1.1e-88 302.9 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2TA Q14680 1 333 651.0 3I7:61334 Type1 Inactive DFGin 6.5851 15.5947 BLAminus -133.48, 179.68 57.39, 75.1 -93.78, 24.78 286.01, 83.45 -43.02, -42.14 in-in in 9.1836 Saltbr-in 2.7995 HRD-in -58.97, -47.79 71.72, 5.83 in-in-out SNCiio in-out ActLoopNT-in 3.4538 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nooi APE10-dihe-na -76.88, 125.32 APE9-dihe-na -93.77, -97.24 APE8-dihe-in -114.6, 140.81 APE8-rot-none 999.0 APE67-dihe-in -50.7, -28.44 -65.82, -47.52 APE12-dist-none 999.0 APE11-dist-out 4.7314 APE10-dist-out 9.3684 APE9-dist-in 3.793 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 A 356.0 316.0 17 29 17 12 [[11, 263]] 1.0 4d2t CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2VB Q14680 2 333 651.0 45R:61334 Type1 Inactive DFGin 6.7673 15.5381 BLAminus -127.49, -177.46 48.61, 80.31 -94.7, 26.52 289.71, 80.82 -57.41, -34.68 in-in in 9.3197 Saltbr-in 2.8391 HRD-in -65.19, -48.0 76.94, -3.24 in-in-out SNCiio in-out ActLoopNT-in 3.4246 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -56.76 APE9-dihe-na 112.15, -141.77 APE8-dihe-in -85.99, 136.21 APE8-rot-none 999.0 APE67-dihe-in -54.61, -16.14 -70.9, -47.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.707 APE9-dist-in 4.639 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 B 356.0 322.0 10 29 23 6 [[11, 263]] 1.0 4d2v CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2WA Q14680 1 333 651.0 NF5:1334 Type1 Inactive DFGin 6.8296 15.8487 BLAminus -125.83, 179.01 60.38, 71.2 -91.14, 19.27 280.32, 83.34 -59.66, -12.38 in-in in 9.216 Saltbr-in 2.7476 HRD-in -75.99, -44.93 74.79, -3.19 in-in-out SNCiio in-out ActLoopNT-in 3.4636 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -2.63 APE9-dihe-na -81.94, -156.44 APE8-dihe-in -43.49, 125.45 APE8-rot-none 999.0 APE67-dihe-in -58.36, -22.97 -57.41, -41.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.2268 APE9-dist-in 4.1644 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 A 356.0 314.0 19 29 16 13 [[11, 263]] 1.0 4d2w CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2WB Q14680 1 333 651.0 NF5:1334 Type1 Inactive DFGin 6.7685 16.0738 BLAminus -125.1, -179.85 60.72, 70.54 -91.12, 19.55 280.74, 84.12 -68.55, -21.97 in-in in 9.7978 Saltbr-in 2.89 HRD-in -70.01, -49.15 73.95, -4.32 in-in-out SNCiio in-out ActLoopNT-in 2.8093 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -40.67 APE9-dihe-na 98.2, 159.82 APE8-dihe-in -49.9, 128.2 APE8-rot-none 999.0 APE67-dihe-in -59.11, -23.33 -59.28, -43.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.7768 APE9-dist-in 4.7388 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 B 356.0 323.0 10 29 23 6 [[11, 263]] 1.0 4d2w CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2WD Q14680 1 333 651.0 NF5:1334 Type1 Inactive DFGin 6.7568 16.1285 BLAminus -128.17, -179.29 58.65, 70.87 -91.82, 22.28 279.98, 81.85 -70.97, -17.86 in-out in 9.9127 Saltbr-out 4.0327 HRD-in -75.62, -48.39 73.85, -2.17 out-in-none SNCoin in-none ActLoopNT-in 2.7897 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, 100.44 APE9-dihe-na 72.37, -170.19 APE8-dihe-in -42.49, 122.48 APE8-rot-none 999.0 APE67-dihe-in -59.49, -22.83 -54.25, -42.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.9529 APE9-dist-in 4.8323 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 D 356.0 326.0 7 29 22 7 [[11, 263]] 1.0 4d2w CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMRA Q14680 6 333 651.0 QBB:1334 Type1 Inactive DFGin 6.8814 14.986 BLAminus -120.8, -168.16 21.55, 76.28 -70.57, -6.67 282.88, 77.1 0.29, -64.21 out-out out 10.7625 Saltbr-out 7.5761 HRD-in -57.13, -46.11 54.81, 26.58 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -55.66 APE9-dihe-na -97.28, 28.4 APE8-dihe-out -98.98, 0.86 APE8-rot-out 56.91 APE67-dihe-in -63.47, -36.6 -58.82, -37.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.3993 APE9-dist-out 11.272 T167A,N213T,V214A,M215A,Y218V,K219A None None XRAY 3.0 0.169 0.224 A 356.0 313.0 15 29 14 15 [[11, 263]] 1.0 4umr CAMK_MELK_HUMAN CAMK 1.8e-87 299.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TVTA Q14680 2 333 651.0 7LV:60401 Type1.5_Back Inactive DFGin 6.4109 14.5647 BLAminus -131.88, 171.47 65.58, 82.76 -99.88, 26.23 296.45, 72.33 -67.22, -25.91 in-in in 9.298 Saltbr-in 3.0551 HRD-in -75.76, -55.29 76.85, 3.89 in-in-out SNCiio in-out ActLoopNT-in 2.8559 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 167.58 APE8-dihe-in -74.77, 128.15 APE8-rot-out 190.78 APE67-dihe-in -66.43, -15.32 -62.74, -42.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.261 None None None XRAY 2.28 0.192 0.229 A 334.0 319.0 13 29 16 13 [[11, 263]] 1.0 5tvt CAMK_MELK_HUMAN CAMK 9.6e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TWLA Q14680 2 333 651.0 H91:64000 Type1.5_Back Inactive DFGin 6.6998 15.1255 BLAminus -128.02, 177.6 60.99, 71.93 -90.97, 39.33 293.12, 81.45 -65.36, -20.56 in-in in 9.169 Saltbr-in 2.9733 HRD-in -74.85, -48.22 64.88, 14.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.63 APE8-dihe-in -64.48, 135.73 APE8-rot-out 193.19 APE67-dihe-in -67.16, -14.03 -70.32, -40.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.3034 None None None XRAY 2.42 0.198 0.249 A 341.0 317.0 15 29 14 15 [[11, 263]] 1.0 5twl CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5MAFA Q14680 2 333 651.0 XIN:60403 Type1.5_Back Inactive DFGin 6.5718 13.907 BLAminus -135.56, 179.58 54.31, 75.2 -95.93, 24.54 296.29, 83.32 -67.92, -21.19 in-in in 8.6899 Saltbr-in 3.0195 HRD-in -58.87, -48.14 62.42, 26.44 in-out-out SNCioo out-out ActLoopNT-out 3.6866 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -32.08 APE8-rot-out 84.93 APE67-dihe-in -58.56, -35.92 -49.67, -38.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.212 0.259 A 347.0 314.0 18 29 15 14 [[11, 263]] 1.0 5maf CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMPB Q14680 1 333 651.0 5QM:1334 Type1.5_Back Inactive DFGin 6.8951 15.4934 BLAminus -117.99, 178.44 56.2, 86.0 -101.46, 12.7 280.7, 91.26 -65.96, -43.06 in-in in 8.973 Saltbr-in 2.6802 HRD-in -74.68, -43.34 71.2, -5.05 in-in-out SNCiio in-out ActLoopNT-in 2.8854 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -52.99 APE9-dihe-na 86.1, -162.56 APE8-dihe-in -66.7, 133.43 APE8-rot-none 999.0 APE67-dihe-in -58.98, -27.1 -62.74, -42.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4326 APE9-dist-in 4.2394 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 B 356.0 324.0 9 29 23 6 [[11, 263]] 1.0 4ump CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMQA Q14680 5 333 651.0 B5S:1334 Type1.5_Back Inactive DFGin 6.7557 15.4092 BLAminus -117.89, 178.23 62.24, 77.5 -76.6, -65.14 271.73, 59.78 68.26, -47.64 out-out out 10.1437 Saltbr-out 4.263 HRD-in -73.03, -44.5 63.1, 15.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -85.77 APE9-dihe-na -154.14, 77.84 APE8-dihe-out -100.21, 46.61 APE8-rot-in 305.67 APE67-dihe-in -43.55, -43.4 -48.33, -39.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.3393 APE9-dist-out 9.4816 T167A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.6 0.212 0.292 A 356.0 314.0 15 29 14 15 [[11, 263]] 1.0 4umq CAMK_MELK_HUMAN CAMK 1.8e-87 299.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5IHCA Q14680 3 327 651.0 6BB:60401 Type1 Inactive DFGin 6.6903 15.0772 BLBminus -128.83, -176.91 47.39, 58.35 -59.3, 135.04 280.62, 79.88 99.65, 999.0 out-out out 10.9108 Saltbr-out 8.7076 HRD-in -78.62, -51.7 71.35, -1.01 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -43.41 APE8-rot-in 292.09 APE67-dihe-in -57.65, -25.08 -53.31, -46.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.179 0.208 A 335.0 304.0 21 29 11 18 [[11, 263]] 1.0 5ihc CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TWYA Q14680 2 333 651.0 7LY:64000 Type1 Inactive DFGin 6.2612 16.0842 None -134.84, -164.53 52.57, 45.85 -53.49, -63.86 258.25, 62.71 46.97, -72.76 out-out out 10.0719 Saltbr-out 4.1074 HRD-in -82.2, -30.32 67.57, -22.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.4 APE8-dihe-out -98.48, 8.41 APE8-rot-none 999.0 APE67-dihe-in -62.0, -32.92 -89.48, -29.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.91 0.288 0.33 A 341.0 311.0 21 29 14 15 [[11, 263]] 1.0 5twy CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5MAIA Q14680 2 333 651.0 5U5:60402 Type1 Inactive DFGin 8.1092 15.0116 None -132.28, 170.97 62.08, 71.15 -94.74, 999.0 292.75, 79.84 999.0, 999.0 out-out out 11.8822 Saltbr-out 8.2222 HRD-in -86.33, -52.07 84.11, -4.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.92 APE8-rot-out 218.22 APE67-dihe-in -56.7, -25.99 -57.2, -38.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.192 0.237 A 347.0 311.0 19 29 10 19 [[11, 263]] 1.0 5mai CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4IXPA Q14680 2 335 651.0 No_ligand No_ligand Inactive DFGinter 8.3366 8.2195 BABtrans -82.53, 111.66 -97.33, 24.09 -131.73, 132.5 172.62, 90.1 -170.06, 168.41 out-none out 11.0643 Saltbr-none 999.0 HRD-in -79.62, -62.46 77.21, 0.17 none-out-out SNCnoo out-out ActLoopNT-out 8.7078 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -61.36, -24.12 APE9-dihe-na -60.42, -37.63 APE8-dihe-out -71.56, -9.7 APE8-rot-in 283.03 APE67-dihe-in -61.32, -17.74 -47.81, -52.79 APE12-dist-out 6.7356 APE11-dist-out 7.6566 APE10-dist-out 13.1677 APE9-dist-out 11.0757 K40R,D150A None None XRAY 2.749 0.202 0.232 A 348.0 334.0 0 29 29 0 [[11, 263]] 1.0 4ixp CAMK_MELK_HUMAN CAMK 3.9e-86 294.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMTA Q14680 3 333 651.0 47W:1335 Type1 Inactive DFGinter 8.3469 9.9483 None -125.65, -174.91 -147.25, 172.21 77.11, 1.19 311.79, 155.98 -66.5, 145.33 out-out out 11.9967 Saltbr-out 13.2724 HRD-in -80.71, -59.49 79.99, -2.05 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -17.83 APE9-dihe-na 40.69, -129.51 APE8-dihe-out -75.85, -1.01 APE8-rot-out 51.67 APE67-dihe-in -62.07, -20.63 -51.04, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1737 APE9-dist-out 11.2606 N213T,V214A,M215A,Y218V,K219A None None XRAY 1.98 0.214 0.236 A 356.0 316.0 15 29 14 15 [[11, 263]] 1.0 4umt CAMK_MELK_HUMAN CAMK 4.5e-88 300.9 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMUA Q14680 3 333 651.0 0V0:1334 Type1 Inactive DFGinter 8.1664 10.1664 None -116.79, -162.79 -155.72, 175.05 72.46, 6.06 306.96, 157.96 -72.63, 148.48 out-out out 12.217 Saltbr-out 13.2373 HRD-in -78.66, -59.93 79.02, -3.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 39.54 APE9-dihe-na 55.48, -131.65 APE8-dihe-out -79.5, 0.32 APE8-rot-out 30.81 APE67-dihe-in -69.91, -20.55 -51.25, -38.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.2516 APE9-dist-out 11.0787 None None None XRAY 2.02 0.207 0.236 A 356.0 316.0 15 29 14 15 [[11, 263]] 1.0 4umu CAMK_MELK_HUMAN CAMK 4.5e-88 300.9 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5K00A Q14680 3 327 651.0 6PV:60401 Type2 Inactive DFGout 15.2921 6.9365 None -128.14, 174.15 -143.5, 90.9 -73.92, -34.47 199.4, 59.51 -97.54, 24.98 out-in out 10.0373 Saltbr-in 3.4485 HRD-in -78.85, -54.15 74.31, -2.16 in-out-none SNCion out-none ActLoopNT-out 4.4562 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -9.29 APE8-rot-in 293.01 APE67-dihe-in -55.94, -25.83 -54.73, -44.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.77 0.175 0.196 A 335.0 310.0 15 29 16 13 [[11, 263]] 1.0 5k00 CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 6VXRA Q14680 1 332 651.0 F7D:401 Type1 Inactive None 999.0 999.0 None -127.35, 176.73 71.93, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 11.2476 Saltbr-none 999.0 HRD-in -70.68, -53.91 75.77, 1.43 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -30.71 APE9-dihe-na -63.58, -35.16 APE8-dihe-out -106.88, 12.59 APE8-rot-in 297.84 APE67-dihe-in -59.4, -25.09 -56.16, -41.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.034 None None None XRAY 2.1 0.221 0.248 A 339.0 309.0 23 29 11 18 [[11, 263]] 1.0 6vxr CAMK_MELK_HUMAN CAMK 1e-88 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TWYB Q14680 2 332 651.0 7LY:64000 Type1 Inactive None 999.0 999.0 None -139.34, 176.96 60.77, 61.97 -105.8, 58.7 999.0, 999.0 -74.0, -12.86 out-none out 10.4171 Saltbr-none 999.0 HRD-in -64.81, -29.27 63.75, -22.08 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.9, -21.65 999.0, 46.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.288 0.33 B 341.0 304.0 27 29 12 17 [[11, 263]] 1.0 5twy CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5TX3B Q14680 1 334 651.0 7MY:61001 Type1 Inactive None 999.0 999.0 None -131.1, 174.26 51.33, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.0053 Saltbr-out 7.9626 HRD-in -64.99, -44.15 50.66, 25.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -112.16 APE8-dihe-in -88.98, 144.8 APE8-rot-out 168.82 APE67-dihe-in -60.11, -5.23 -84.75, -45.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.273 None None None XRAY 2.9 0.189 0.253 B 344.0 297.0 37 29 10 19 [[11, 263]] 1.0 5tx3 CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5IH8A Q14680 3 327 651.0 6BJ:60401 Type1 None DFGin 6.8987 15.0152 BLAminus -123.97, 176.03 57.35, 81.53 -98.01, 22.13 281.32, 75.72 -67.27, -27.19 in-in in 8.68 Saltbr-in 2.7081 HRD-in -68.78, -51.48 74.83, -1.98 in-in-none SNCiin in-none ActLoopNT-in 2.9246 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -5.67 APE8-rot-in 289.51 APE67-dihe-in -61.1, -22.21 -55.23, -38.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.178 0.2 A 335.0 305.0 20 29 15 14 [[11, 263]] 1.0 5ih8 CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.9392 15.1461 BLAminus -123.48, 176.08 58.26, 79.91 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.7195 Saltbr-in 2.5866 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.9916 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335.0 307.0 18 29 15 14 [[11, 263]] 1.0 5ih9 CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 5IHAA Q14680 3 327 651.0 6BE:60401 Type1 None DFGin 6.8292 15.0418 BLAminus -120.87, 177.4 55.95, 85.64 -102.14, 23.45 281.65, 80.18 -67.54, -28.51 in-in in 8.8421 Saltbr-in 2.6324 HRD-in -71.43, -49.46 70.45, 4.23 in-in-none SNCiin in-none ActLoopNT-in 3.0338 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.72 APE8-rot-in 296.55 APE67-dihe-in -57.19, -26.87 -59.91, -43.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.175 0.202 A 335.0 302.0 23 29 15 14 [[11, 263]] 1.0 5iha CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 6GVXA Q14680 1 333 651.0 TAK:60402 Type1 None DFGin 6.711 15.2598 BLAminus -125.4, 178.58 58.73, 78.31 -98.95, 27.88 285.76, 76.62 -69.49, -24.6 in-in in 9.0037 Saltbr-in 2.9077 HRD-in -62.31, -45.72 65.24, 14.32 in-in-none SNCiin in-none ActLoopNT-in 2.8688 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -86.88 APE9-dihe-na -85.92, -154.54 APE8-dihe-in -73.43, 134.24 APE8-rot-in 297.0 APE67-dihe-in -62.55, -20.46 -61.75, -38.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.5188 APE9-dist-in 4.4863 None None None XRAY 2.24 0.205 0.24 A 344.0 311.0 15 29 22 7 [[11, 263]] 1.0 6gvx CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4BKYA Q14680 3 333 651.0 82B:1334 Type1 None DFGin 6.8606 14.7894 BLAminus -126.95, 173.05 62.71, 72.79 -92.87, 16.6 286.13, 76.41 -58.61, -28.78 in-in in 8.5922 Saltbr-in 2.5968 HRD-in -70.13, -52.15 72.52, 2.08 in-in-none SNCiin in-none ActLoopNT-in 3.0117 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -30.73 APE8-rot-in 283.32 APE67-dihe-in -55.55, -24.59 -55.8, -42.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.83 0.204 0.223 A 347.0 311.0 20 29 14 15 [[11, 263]] 1.0 4bky CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2TB Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.5171 15.4821 BLAminus -134.63, -178.27 55.46, 74.9 -94.29, 23.67 286.62, 83.25 -66.74, -35.72 in-in in 9.1486 Saltbr-in 2.7878 HRD-in -58.96, -48.62 71.55, 4.62 in-in-none SNCiin in-none ActLoopNT-in 2.8087 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -118.25 APE9-dihe-na 126.7, -132.88 APE8-dihe-in -115.61, 136.66 APE8-rot-none 999.0 APE67-dihe-in -51.25, -29.04 -60.65, -47.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.181 APE9-dist-in 3.7237 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 B 356.0 322.0 11 29 23 6 [[11, 263]] 1.0 4d2t CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2TC Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.6299 15.5937 BLAminus -134.25, 179.33 57.66, 74.82 -93.87, 24.92 285.83, 82.78 -70.22, -25.26 in-in in 9.1534 Saltbr-in 2.7964 HRD-in -57.46, -50.13 71.26, 4.63 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -131.47 APE8-dihe-in -117.46, 135.5 APE8-rot-none 999.0 APE67-dihe-in -52.13, -27.45 -60.57, -47.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6849 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 C 356.0 313.0 20 29 16 13 [[11, 263]] 1.0 4d2t CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2TD Q14680 3 333 651.0 3I7:61334 Type1 None DFGin 6.4951 15.5371 BLAminus -130.9, 164.85 58.81, 83.3 -99.74, 25.07 285.57, 83.05 -62.72, -39.18 in-in in 9.2669 Saltbr-in 2.7983 HRD-in -58.57, -49.69 71.95, 4.52 in-in-none SNCiin in-none ActLoopNT-in 2.7966 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -132.43 APE8-dihe-in -116.12, 138.43 APE8-rot-none 999.0 APE67-dihe-in -52.16, -28.22 -60.64, -47.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7327 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 D 356.0 319.0 8 29 21 8 [[11, 263]] 1.0 4d2t CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2VA Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.7918 15.7043 BLAminus -128.16, -178.54 46.67, 81.9 -94.66, 26.37 289.35, 79.84 -48.93, -31.86 in-in in 9.3877 Saltbr-in 2.8703 HRD-in -64.57, -46.97 77.06, -5.55 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.0 APE8-dihe-in -89.53, 134.8 APE8-rot-none 999.0 APE67-dihe-in -53.64, -18.08 -71.01, -44.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.5915 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 A 356.0 312.0 21 29 14 15 [[11, 263]] 1.0 4d2v CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2VC Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.7731 15.7676 BLAminus -127.7, -179.29 47.99, 81.71 -95.83, 24.05 288.88, 80.0 -69.4, -23.25 in-in in 9.3912 Saltbr-in 2.8658 HRD-in -64.65, -48.16 76.02, -3.72 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -147.18 APE8-dihe-in -89.76, 137.08 APE8-rot-none 999.0 APE67-dihe-in -54.65, -16.89 -71.35, -44.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.6099 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 C 356.0 316.0 17 29 16 13 [[11, 263]] 1.0 4d2v CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2VD Q14680 3 333 651.0 45R:61334 Type1 None DFGin 6.7572 15.6573 BLAminus -128.1, -177.36 48.27, 80.83 -95.04, 26.93 289.26, 79.87 -56.22, -36.0 in-in in 9.4377 Saltbr-in 2.8471 HRD-in -64.33, -48.39 77.06, -3.92 in-in-none SNCiin in-none ActLoopNT-in 3.3829 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.49 APE8-dihe-in -88.59, 137.31 APE8-rot-none 999.0 APE67-dihe-in -54.66, -16.96 -72.15, -45.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.6481 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 D 356.0 318.0 8 29 21 8 [[11, 263]] 1.0 4d2v CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2WC Q14680 1 333 651.0 NF5:1334 Type1 None DFGin 6.8567 15.6417 BLAminus -123.79, 178.59 60.65, 71.55 -90.39, 19.57 282.34, 80.84 -69.3, -20.74 in-in in 8.998 Saltbr-in 2.7431 HRD-in -74.38, -48.87 73.02, -0.95 in-in-none SNCiin in-none ActLoopNT-in 3.019 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.96 APE8-dihe-in -49.29, 128.09 APE8-rot-none 999.0 APE67-dihe-in -59.65, -22.66 -56.52, -44.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.7473 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 C 356.0 313.0 20 29 16 13 [[11, 263]] 1.0 4d2w CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMPD Q14680 2 333 651.0 5QM:1334 Type1 None DFGin 6.8683 15.5379 BLAminus -128.98, 172.85 60.45, 81.99 -100.97, 13.83 278.54, 87.38 -58.85, -32.32 in-in in 9.1233 Saltbr-in 2.7582 HRD-in -66.2, -47.15 69.3, -6.44 in-in-none SNCiin in-none ActLoopNT-in 2.8848 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.38 APE8-dihe-in -63.2, 133.11 APE8-rot-none 999.0 APE67-dihe-in -59.09, -26.16 -63.77, -40.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2378 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 D 356.0 321.0 7 29 22 7 [[11, 263]] 1.0 4ump CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2PA Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.7667 15.4363 BLAminus -121.57, -178.43 43.06, 87.01 -96.75, 36.15 287.09, 78.41 -62.79, -28.68 in-in in 9.8625 Saltbr-in 3.4885 HRD-in -65.09, -43.36 70.33, -2.48 in-in-none SNCiin in-none ActLoopNT-in 3.474 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.47 APE8-dihe-in -63.07, 132.76 APE8-rot-none 999.0 APE67-dihe-in -56.46, -25.28 -62.72, -43.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1304 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 A 356.0 313.0 20 29 15 14 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2PB Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.8039 15.267 BLAminus -116.15, -179.55 42.83, 87.18 -95.49, 33.61 286.93, 77.41 -73.57, -28.71 in-in in 9.6914 Saltbr-in 3.386 HRD-in -66.38, -43.95 69.75, -0.06 in-in-none SNCiin in-none ActLoopNT-in 3.1554 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -89.14 APE9-dihe-na 110.05, -162.04 APE8-dihe-in -67.8, 135.44 APE8-rot-none 999.0 APE67-dihe-in -55.82, -25.74 -63.48, -45.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.3555 APE9-dist-in 4.242 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 B 356.0 323.0 10 29 23 6 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2PC Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.7697 15.2354 BLAminus -121.44, -178.21 43.87, 86.48 -97.16, 31.68 287.92, 77.16 -71.21, -25.62 in-in in 9.5803 Saltbr-in 3.2543 HRD-in -64.88, -44.62 70.79, 0.06 in-in-none SNCiin in-none ActLoopNT-in 2.8678 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.51 APE8-dihe-in -65.31, 136.43 APE8-rot-none 999.0 APE67-dihe-in -56.72, -24.92 -63.56, -46.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1999 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 C 356.0 315.0 18 29 16 13 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4D2PD Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.7784 15.2623 BLAminus -121.01, -179.74 44.13, 87.06 -96.7, 34.13 287.58, 76.33 -72.88, -28.13 in-in in 9.882 Saltbr-in 3.4699 HRD-in -66.46, -43.59 69.94, 0.8 in-in-none SNCiin in-none ActLoopNT-in 3.0905 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.68 APE8-dihe-in -65.17, 134.89 APE8-rot-none 999.0 APE67-dihe-in -55.96, -25.2 -65.21, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2064 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 D 356.0 317.0 7 29 22 7 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMPA Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.7782 15.2943 BLAminus -116.7, -176.8 54.54, 81.11 -105.57, 22.84 278.1, 82.0 -64.7, -26.81 in-in in 9.1873 Saltbr-in 2.7412 HRD-in -68.68, -33.57 59.29, 16.14 in-in-none SNCiin in-none ActLoopNT-in 3.4042 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.18 APE8-dihe-in -64.9, 131.94 APE8-rot-none 999.0 APE67-dihe-in -58.2, -28.41 -61.43, -40.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9888 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 A 356.0 313.0 20 29 15 14 [[11, 263]] 1.0 4ump CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK 4UMPC Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.8027 15.5432 BLAminus -123.91, -179.28 56.39, 85.45 -103.47, 13.92 280.5, 85.56 -60.17, -35.76 in-in in 9.0508 Saltbr-in 2.7367 HRD-in -71.35, -45.77 70.39, -10.7 in-in-none SNCiin in-none ActLoopNT-in 2.9074 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.15 APE8-dihe-in -66.96, 131.15 APE8-rot-none 999.0 APE67-dihe-in -60.1, -27.83 -60.42, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.5871 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 C 356.0 311.0 22 29 16 13 [[11, 263]] 1.0 4ump CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase

CAMK_MELK (Maternal embryonic leucine zipper kinase)

Total number of chains: 55
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 43 78.2% AF-Q14680-K1A
None None 3 5.5% 6VXRA
DFGin ABAminus 2 3.6% 4BL1A
DFGin None 2 3.6% 5MAIA
DFGinter None 2 3.6% 4UMTA
DFGin BLBminus 1 1.8% 5IHCA
DFGinter BABtrans 1 1.8% 4IXPA
DFGout None 1 1.8% 5K00A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MELK MELK_HUMAN AF-Q14680-K1A Q14680 3 271 651.0 No_ligand No_ligand Active DFGin 6.6628 14.8519 BLAminus -121.05, -178.94 55.54, 67.09 -78.42, 16.52 286.9, 79.58 -60.33, -23.28 in-in in 9.3046 Saltbr-in 2.7248 HRD-in -75.84, -50.36 66.57, 14.62 in-in-in SNCiii in-in ActLoopNT-in 3.0165 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 166.92 APE9-dihe-na 98.89, 172.09 APE8-dihe-in -67.52, 132.67 APE8-rot-in 286.83 APE67-dihe-in -68.01, -21.76 -55.55, -41.05 APE12-dist-in 8.6652 APE11-dist-in 11.2938 APE10-dist-in 5.6748 APE9-dist-in 3.779 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 29 29 0 [[11, 263]] 1.0 AF-Q14680-K1 Homo sapiens CAMK_MELK_HUMAN CAMK 4.4e-89 304.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN AF-Q14680-K3A Q14680 3 271 651.0 No_ligand No_ligand Active DFGin 6.498 14.8248 BLAminus -123.1, -178.85 53.35, 68.52 -77.81, 16.02 289.31, 78.98 -63.89, -14.25 in-in in 9.2137 Saltbr-in 2.7053 HRD-in -77.78, -49.26 68.33, 6.33 in-in-in SNCiii in-in ActLoopNT-in 2.9112 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.84, 171.36 APE9-dihe-na 95.07, 170.83 APE8-dihe-in -65.23, 128.46 APE8-rot-in 280.71 APE67-dihe-in -62.2, -18.93 -58.85, -41.82 APE12-dist-in 8.6445 APE11-dist-in 11.6067 APE10-dist-in 6.0114 APE9-dist-in 3.5359 None None None AF2 -1.0 1.0 1.0 A 269.0 269.0 0 29 29 0 [[11, 263]] 1.0 AF-Q14680-K3 Homo sapiens CAMK_MELK_HUMAN CAMK 4.4e-89 304.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4BL1A Q14680 2 333 651.0 ANP:1000 ATPlike Inactive DFGin 6.3379 13.9347 ABAminus -114.35, -16.21 -125.02, 95.86 -105.85, 20.97 306.05, 72.32 -48.23, -28.35 in-in in 8.5656 Saltbr-in 2.6282 HRD-in -47.49, -61.71 83.33, 5.93 in-in-out SNCiio in-out ActLoopNT-in 3.0985 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.09 APE8-rot-out 166.93 APE67-dihe-in -51.79, -28.37 -37.56, -42.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.184 0.26 A 347.0 312.0 20 29 15 14 [[11, 263]] 1.0 4bl1 Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TX3A Q14680 1 333 651.0 7MY:61000 Type1 Inactive DFGin 6.7086 15.7403 ABAminus -129.52, -56.19 -85.52, 113.68 -108.84, 24.42 293.03, 74.98 -57.98, -30.68 out-out out 11.7923 Saltbr-out 8.8638 HRD-in -62.75, -40.48 54.82, 17.38 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -113.41 APE8-dihe-in -87.51, 145.06 APE8-rot-out 167.33 APE67-dihe-in -59.02, -7.95 -81.22, -43.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.4199 None None None XRAY 2.9 0.189 0.253 A 344.0 303.0 30 29 13 16 [[11, 263]] 1.0 5tx3 Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TWUA Q14680 1 333 651.0 No_ligand No_ligand Inactive DFGin 6.6969 15.6536 BLAminus -129.99, 179.95 65.09, 74.8 -95.36, 28.06 283.61, 75.01 -65.09, -29.27 in-in in 9.194 Saltbr-in 3.056 HRD-in -69.34, -46.52 71.86, 4.44 in-in-out SNCiio in-out ActLoopNT-in 2.7968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.41 APE8-dihe-in -91.14, 149.5 APE8-rot-out 65.84 APE67-dihe-in -55.13, -22.29 -65.51, -45.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9215 None None None XRAY 2.603 0.167 0.235 A 344.0 315.0 18 29 22 7 [[11, 263]] 1.0 5twu Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TWUB Q14680 1 335 651.0 No_ligand No_ligand Inactive DFGin 6.5668 15.9032 BLAminus -128.11, -176.85 63.36, 72.51 -97.13, 27.9 284.98, 79.21 -66.22, -30.22 in-in in 9.5403 Saltbr-in 2.9284 HRD-in -67.9, -46.44 71.63, 6.08 in-in-out SNCiio in-out ActLoopNT-in 3.0712 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoi APE10-dihe-na 999.0, 86.14 APE9-dihe-na -79.32, -138.67 APE8-dihe-in -88.52, 146.37 APE8-rot-out 63.54 APE67-dihe-in -55.93, -22.54 -67.27, -45.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.0414 APE9-dist-in 3.8369 None None None XRAY 2.603 0.167 0.235 B 344.0 311.0 24 29 17 12 [[11, 263]] 1.0 5twu Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TWZA Q14680 2 333 651.0 45R:61000 Type1 Inactive DFGin 6.0558 15.1103 BLAminus -135.13, 175.3 50.67, 77.34 -80.78, 119.22 288.77, 77.67 -133.08, 999.0 out-none out 11.9674 Saltbr-none 999.0 HRD-in -71.45, -42.53 66.57, 4.79 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 113.11 APE8-dihe-in -104.75, 96.77 APE8-rot-out 175.45 APE67-dihe-in -67.58, -11.75 -76.23, -35.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.3243 None None None XRAY 2.631 0.223 0.259 A 341.0 312.0 20 29 12 17 [[11, 263]] 1.0 5twz Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 6GVXB Q14680 1 335 651.0 TAK:60402 Type1 Inactive DFGin 6.7539 15.4942 BLAminus -124.69, 179.93 57.83, 81.5 -101.39, 28.11 283.05, 78.99 -70.11, -31.83 in-in in 9.0647 Saltbr-in 2.472 HRD-in -64.06, -46.18 61.47, 17.03 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -127.94 APE8-dihe-in -66.05, 131.75 APE8-rot-out 178.58 APE67-dihe-in -65.84, -20.47 -62.83, -40.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.407 None None None XRAY 2.24 0.205 0.24 B 344.0 315.0 20 29 17 12 [[11, 263]] 1.0 6gvx Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4BKZA Q14680 2 334 651.0 1WS:1335 Type1 Inactive DFGin 6.6847 14.9959 BLAminus -122.33, 174.76 61.2, 76.56 -93.17, 28.31 293.04, 71.56 -72.57, -28.75 in-in in 9.3324 Saltbr-in 2.9998 HRD-in -72.3, -44.46 69.02, -4.23 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -17.58 APE8-rot-out 93.23 APE67-dihe-in -45.75, -36.65 -58.97, -41.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.201 0.24 A 347.0 309.0 24 29 14 15 [[11, 263]] 1.0 4bkz Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5M5AA Q14680 2 333 651.0 KSA:404 Type1 Inactive DFGin 6.5676 14.3671 BLAminus -128.52, 174.95 69.66, 80.58 -99.26, 20.16 288.02, 75.17 -59.14, -23.43 in-in in 9.7218 Saltbr-in 2.6179 HRD-in -77.9, -54.21 76.42, -2.14 in-in-out SNCiio in-out ActLoopNT-in 2.9942 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -68.55 APE8-rot-out 186.58 APE67-dihe-in -58.12, -27.37 -53.28, -41.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.187 0.214 A 347.0 315.0 17 29 14 15 [[11, 263]] 1.0 5m5a Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5MAGA Q14680 3 335 651.0 7KC:401 Type1 Inactive DFGin 6.6918 14.9869 BLAminus -126.92, 174.57 68.63, 74.58 -97.26, 21.55 288.43, 79.18 -64.62, -40.12 in-in in 9.0518 Saltbr-in 2.8291 HRD-in -73.74, -51.64 77.77, -11.12 in-in-out SNCiio in-out ActLoopNT-in 3.007 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.12 APE8-rot-out 175.02 APE67-dihe-in -58.72, -25.6 -61.09, -40.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.35 0.196 0.252 A 347.0 314.0 19 29 15 14 [[11, 263]] 1.0 5mag Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5MAHA Q14680 2 333 651.0 7KD:401 Type1 Inactive DFGin 6.8254 14.4815 BLAminus -125.71, 172.04 69.81, 78.26 -96.5, 20.96 290.79, 71.84 -62.8, -27.67 in-in in 8.5728 Saltbr-in 2.6261 HRD-in -72.24, -51.67 74.84, 2.35 in-in-out SNCiio in-out ActLoopNT-in 2.8845 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -55.15 APE8-rot-out 194.61 APE67-dihe-in -57.26, -25.97 -56.03, -40.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.185 0.237 A 347.0 316.0 16 29 15 14 [[11, 263]] 1.0 5mah Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 9F31A Q14680 1 335 651.0 A1H9M:401 Type1 Inactive DFGin 7.4487 14.5944 BLAminus -119.6, 170.59 71.52, 65.71 -71.15, -65.91 280.26, 79.82 -135.18, -136.64 out-out out 11.3729 Saltbr-out 7.3243 HRD-in -90.64, -49.21 79.03, -5.96 out-out-out SNCooo out-out ActLoopNT-out 12.603 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -26.08 APE8-rot-out 185.8 APE67-dihe-in -60.0, -24.89 -65.19, -21.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.191 0.233 A 349.0 320.0 15 29 14 15 [[11, 263]] 1.0 9f31 Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 302.9 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2TA Q14680 1 333 651.0 3I7:61334 Type1 Inactive DFGin 6.5851 15.5947 BLAminus -133.48, 179.68 57.39, 75.1 -93.78, 24.78 286.01, 83.45 -43.02, -42.14 in-in in 9.1836 Saltbr-in 2.7995 HRD-in -58.97, -47.79 71.72, 5.83 in-in-out SNCiio in-out ActLoopNT-in 3.4538 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nooi APE10-dihe-na -76.88, 125.32 APE9-dihe-na -93.77, -97.24 APE8-dihe-in -114.6, 140.81 APE8-rot-none 999.0 APE67-dihe-in -50.7, -28.44 -65.82, -47.52 APE12-dist-none 999.0 APE11-dist-out 4.7314 APE10-dist-out 9.3684 APE9-dist-in 3.793 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 A 356.0 316.0 17 29 17 12 [[11, 263]] 1.0 4d2t Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2VB Q14680 2 333 651.0 45R:61334 Type1 Inactive DFGin 6.7673 15.5381 BLAminus -127.49, -177.46 48.61, 80.31 -94.7, 26.52 289.71, 80.82 -57.41, -34.68 in-in in 9.3197 Saltbr-in 2.8391 HRD-in -65.19, -48.0 76.94, -3.24 in-in-out SNCiio in-out ActLoopNT-in 3.4246 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -56.76 APE9-dihe-na 112.15, -141.77 APE8-dihe-in -85.99, 136.21 APE8-rot-none 999.0 APE67-dihe-in -54.61, -16.14 -70.9, -47.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.707 APE9-dist-in 4.639 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 B 356.0 322.0 10 29 23 6 [[11, 263]] 1.0 4d2v Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2WA Q14680 1 333 651.0 NF5:1334 Type1 Inactive DFGin 6.8296 15.8487 BLAminus -125.83, 179.01 60.38, 71.2 -91.14, 19.27 280.32, 83.34 -59.66, -12.38 in-in in 9.216 Saltbr-in 2.7476 HRD-in -75.99, -44.93 74.79, -3.19 in-in-out SNCiio in-out ActLoopNT-in 3.4636 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -2.63 APE9-dihe-na -81.94, -156.44 APE8-dihe-in -43.49, 125.45 APE8-rot-none 999.0 APE67-dihe-in -58.36, -22.97 -57.41, -41.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.2268 APE9-dist-in 4.1644 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 A 356.0 314.0 19 29 16 13 [[11, 263]] 1.0 4d2w Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2WB Q14680 1 333 651.0 NF5:1334 Type1 Inactive DFGin 6.7685 16.0738 BLAminus -125.1, -179.85 60.72, 70.54 -91.12, 19.55 280.74, 84.12 -68.55, -21.97 in-in in 9.7978 Saltbr-in 2.89 HRD-in -70.01, -49.15 73.95, -4.32 in-in-out SNCiio in-out ActLoopNT-in 2.8093 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -40.67 APE9-dihe-na 98.2, 159.82 APE8-dihe-in -49.9, 128.2 APE8-rot-none 999.0 APE67-dihe-in -59.11, -23.33 -59.28, -43.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.7768 APE9-dist-in 4.7388 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 B 356.0 323.0 10 29 23 6 [[11, 263]] 1.0 4d2w Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2WD Q14680 1 333 651.0 NF5:1334 Type1 Inactive DFGin 6.7568 16.1285 BLAminus -128.17, -179.29 58.65, 70.87 -91.82, 22.28 279.98, 81.85 -70.97, -17.86 in-out in 9.9127 Saltbr-out 4.0327 HRD-in -75.62, -48.39 73.85, -2.17 out-in-none SNCoin in-none ActLoopNT-in 2.7897 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, 100.44 APE9-dihe-na 72.37, -170.19 APE8-dihe-in -42.49, 122.48 APE8-rot-none 999.0 APE67-dihe-in -59.49, -22.83 -54.25, -42.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.9529 APE9-dist-in 4.8323 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 D 356.0 326.0 7 29 22 7 [[11, 263]] 1.0 4d2w Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMRA Q14680 6 333 651.0 QBB:1334 Type1 Inactive DFGin 6.8814 14.986 BLAminus -120.8, -168.16 21.55, 76.28 -70.57, -6.67 282.88, 77.1 0.29, -64.21 out-out out 10.7625 Saltbr-out 7.5761 HRD-in -57.13, -46.11 54.81, 26.58 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -55.66 APE9-dihe-na -97.28, 28.4 APE8-dihe-out -98.98, 0.86 APE8-rot-out 56.91 APE67-dihe-in -63.47, -36.6 -58.82, -37.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.3993 APE9-dist-out 11.272 T167A,N213T,V214A,M215A,Y218V,K219A None None XRAY 3.0 0.169 0.224 A 356.0 313.0 15 29 14 15 [[11, 263]] 1.0 4umr Homo sapiens CAMK_MELK_HUMAN CAMK 1.8e-87 299.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TVTA Q14680 2 333 651.0 7LV:60401 Type1.5_Back Inactive DFGin 6.4109 14.5647 BLAminus -131.88, 171.47 65.58, 82.76 -99.88, 26.23 296.45, 72.33 -67.22, -25.91 in-in in 9.298 Saltbr-in 3.0551 HRD-in -75.76, -55.29 76.85, 3.89 in-in-out SNCiio in-out ActLoopNT-in 2.8559 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 167.58 APE8-dihe-in -74.77, 128.15 APE8-rot-out 190.78 APE67-dihe-in -66.43, -15.32 -62.74, -42.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.261 None None None XRAY 2.28 0.192 0.229 A 334.0 319.0 13 29 16 13 [[11, 263]] 1.0 5tvt Homo sapiens CAMK_MELK_HUMAN CAMK 9.6e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TWLA Q14680 2 333 651.0 H91:64000 Type1.5_Back Inactive DFGin 6.6998 15.1255 BLAminus -128.02, 177.6 60.99, 71.93 -90.97, 39.33 293.12, 81.45 -65.36, -20.56 in-in in 9.169 Saltbr-in 2.9733 HRD-in -74.85, -48.22 64.88, 14.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.63 APE8-dihe-in -64.48, 135.73 APE8-rot-out 193.19 APE67-dihe-in -67.16, -14.03 -70.32, -40.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.3034 None None None XRAY 2.42 0.198 0.249 A 341.0 317.0 15 29 14 15 [[11, 263]] 1.0 5twl Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5MAFA Q14680 2 333 651.0 XIN:60403 Type1.5_Back Inactive DFGin 6.5718 13.907 BLAminus -135.56, 179.58 54.31, 75.2 -95.93, 24.54 296.29, 83.32 -67.92, -21.19 in-in in 8.6899 Saltbr-in 3.0195 HRD-in -58.87, -48.14 62.42, 26.44 in-out-out SNCioo out-out ActLoopNT-out 3.6866 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -32.08 APE8-rot-out 84.93 APE67-dihe-in -58.56, -35.92 -49.67, -38.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.212 0.259 A 347.0 314.0 18 29 15 14 [[11, 263]] 1.0 5maf Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMPB Q14680 1 333 651.0 5QM:1334 Type1.5_Back Inactive DFGin 6.8951 15.4934 BLAminus -117.99, 178.44 56.2, 86.0 -101.46, 12.7 280.7, 91.26 -65.96, -43.06 in-in in 8.973 Saltbr-in 2.6802 HRD-in -74.68, -43.34 71.2, -5.05 in-in-out SNCiio in-out ActLoopNT-in 2.8854 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoi APE10-dihe-na 999.0, -52.99 APE9-dihe-na 86.1, -162.56 APE8-dihe-in -66.7, 133.43 APE8-rot-none 999.0 APE67-dihe-in -58.98, -27.1 -62.74, -42.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4326 APE9-dist-in 4.2394 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 B 356.0 324.0 9 29 23 6 [[11, 263]] 1.0 4ump Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMQA Q14680 5 333 651.0 B5S:1334 Type1.5_Back Inactive DFGin 6.7557 15.4092 BLAminus -117.89, 178.23 62.24, 77.5 -76.6, -65.14 271.73, 59.78 68.26, -47.64 out-out out 10.1437 Saltbr-out 4.263 HRD-in -73.03, -44.5 63.1, 15.67 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, -85.77 APE9-dihe-na -154.14, 77.84 APE8-dihe-out -100.21, 46.61 APE8-rot-in 305.67 APE67-dihe-in -43.55, -43.4 -48.33, -39.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.3393 APE9-dist-out 9.4816 T167A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.6 0.212 0.292 A 356.0 314.0 15 29 14 15 [[11, 263]] 1.0 4umq Homo sapiens CAMK_MELK_HUMAN CAMK 1.8e-87 299.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5IHCA Q14680 3 327 651.0 6BB:60401 Type1 Inactive DFGin 6.6903 15.0772 BLBminus -128.83, -176.91 47.39, 58.35 -59.3, 135.04 280.62, 79.88 99.65, 999.0 out-out out 10.9108 Saltbr-out 8.7076 HRD-in -78.62, -51.7 71.35, -1.01 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -43.41 APE8-rot-in 292.09 APE67-dihe-in -57.65, -25.08 -53.31, -46.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.14 0.179 0.208 A 335.0 304.0 21 29 11 18 [[11, 263]] 1.0 5ihc Homo sapiens CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TWYA Q14680 2 333 651.0 7LY:64000 Type1 Inactive DFGin 6.2612 16.0842 None -134.84, -164.53 52.57, 45.85 -53.49, -63.86 258.25, 62.71 46.97, -72.76 out-out out 10.0719 Saltbr-out 4.1074 HRD-in -82.2, -30.32 67.57, -22.88 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -21.4 APE8-dihe-out -98.48, 8.41 APE8-rot-none 999.0 APE67-dihe-in -62.0, -32.92 -89.48, -29.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.225 None None None XRAY 2.91 0.288 0.33 A 341.0 311.0 21 29 14 15 [[11, 263]] 1.0 5twy Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5MAIA Q14680 2 333 651.0 5U5:60402 Type1 Inactive DFGin 8.1092 15.0116 None -132.28, 170.97 62.08, 71.15 -94.74, 999.0 292.75, 79.84 999.0, 999.0 out-out out 11.8822 Saltbr-out 8.2222 HRD-in -86.33, -52.07 84.11, -4.76 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -42.92 APE8-rot-out 218.22 APE67-dihe-in -56.7, -25.99 -57.2, -38.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.192 0.237 A 347.0 311.0 19 29 10 19 [[11, 263]] 1.0 5mai Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4IXPA Q14680 2 335 651.0 No_ligand No_ligand Inactive DFGinter 8.3366 8.2195 BABtrans -82.53, 111.66 -97.33, 24.09 -131.73, 132.5 172.62, 90.1 -170.06, 168.41 out-none out 11.0643 Saltbr-none 999.0 HRD-in -79.62, -62.46 77.21, 0.17 none-out-out SNCnoo out-out ActLoopNT-out 8.7078 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -61.36, -24.12 APE9-dihe-na -60.42, -37.63 APE8-dihe-out -71.56, -9.7 APE8-rot-in 283.03 APE67-dihe-in -61.32, -17.74 -47.81, -52.79 APE12-dist-out 6.7356 APE11-dist-out 7.6566 APE10-dist-out 13.1677 APE9-dist-out 11.0757 K40R,D150A None None XRAY 2.749 0.202 0.232 A 348.0 334.0 0 29 29 0 [[11, 263]] 1.0 4ixp Homo sapiens CAMK_MELK_HUMAN CAMK 3.9e-86 294.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMTA Q14680 3 333 651.0 47W:1335 Type1 Inactive DFGinter 8.3469 9.9483 None -125.65, -174.91 -147.25, 172.21 77.11, 1.19 311.79, 155.98 -66.5, 145.33 out-out out 11.9967 Saltbr-out 13.2724 HRD-in -80.71, -59.49 79.99, -2.05 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -17.83 APE9-dihe-na 40.69, -129.51 APE8-dihe-out -75.85, -1.01 APE8-rot-out 51.67 APE67-dihe-in -62.07, -20.63 -51.04, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.1737 APE9-dist-out 11.2606 N213T,V214A,M215A,Y218V,K219A None None XRAY 1.98 0.214 0.236 A 356.0 316.0 15 29 14 15 [[11, 263]] 1.0 4umt Homo sapiens CAMK_MELK_HUMAN CAMK 4.5e-88 300.9 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMUA Q14680 3 333 651.0 0V0:1334 Type1 Inactive DFGinter 8.1664 10.1664 None -116.79, -162.79 -155.72, 175.05 72.46, 6.06 306.96, 157.96 -72.63, 148.48 out-out out 12.217 Saltbr-out 13.2373 HRD-in -78.66, -59.93 79.02, -3.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 39.54 APE9-dihe-na 55.48, -131.65 APE8-dihe-out -79.5, 0.32 APE8-rot-out 30.81 APE67-dihe-in -69.91, -20.55 -51.25, -38.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.2516 APE9-dist-out 11.0787 None None None XRAY 2.02 0.207 0.236 A 356.0 316.0 15 29 14 15 [[11, 263]] 1.0 4umu Homo sapiens CAMK_MELK_HUMAN CAMK 4.5e-88 300.9 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5K00A Q14680 3 327 651.0 6PV:60401 Type2 Inactive DFGout 15.2921 6.9365 None -128.14, 174.15 -143.5, 90.9 -73.92, -34.47 199.4, 59.51 -97.54, 24.98 out-in out 10.0373 Saltbr-in 3.4485 HRD-in -78.85, -54.15 74.31, -2.16 in-out-none SNCion out-none ActLoopNT-out 4.4562 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -9.29 APE8-rot-in 293.01 APE67-dihe-in -55.94, -25.83 -54.73, -44.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.77 0.175 0.196 A 335.0 310.0 15 29 16 13 [[11, 263]] 1.0 5k00 Homo sapiens CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 6VXRA Q14680 1 332 651.0 F7D:401 Type1 Inactive None 999.0 999.0 None -127.35, 176.73 71.93, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 11.2476 Saltbr-none 999.0 HRD-in -70.68, -53.91 75.77, 1.43 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, -30.71 APE9-dihe-na -63.58, -35.16 APE8-dihe-out -106.88, 12.59 APE8-rot-in 297.84 APE67-dihe-in -59.4, -25.09 -56.16, -41.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.034 None None None XRAY 2.1 0.221 0.248 A 339.0 309.0 23 29 11 18 [[11, 263]] 1.0 6vxr Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TWYB Q14680 2 332 651.0 7LY:64000 Type1 Inactive None 999.0 999.0 None -139.34, 176.96 60.77, 61.97 -105.8, 58.7 999.0, 999.0 -74.0, -12.86 out-none out 10.4171 Saltbr-none 999.0 HRD-in -64.81, -29.27 63.75, -22.08 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.9, -21.65 999.0, 46.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.91 0.288 0.33 B 341.0 304.0 27 29 12 17 [[11, 263]] 1.0 5twy Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5TX3B Q14680 1 334 651.0 7MY:61001 Type1 Inactive None 999.0 999.0 None -131.1, 174.26 51.33, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-out out 12.0053 Saltbr-out 7.9626 HRD-in -64.99, -44.15 50.66, 25.81 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -112.16 APE8-dihe-in -88.98, 144.8 APE8-rot-out 168.82 APE67-dihe-in -60.11, -5.23 -84.75, -45.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.273 None None None XRAY 2.9 0.189 0.253 B 344.0 297.0 37 29 10 19 [[11, 263]] 1.0 5tx3 Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5IH8A Q14680 3 327 651.0 6BJ:60401 Type1 None DFGin 6.8987 15.0152 BLAminus -123.97, 176.03 57.35, 81.53 -98.01, 22.13 281.32, 75.72 -67.27, -27.19 in-in in 8.68 Saltbr-in 2.7081 HRD-in -68.78, -51.48 74.83, -1.98 in-in-none SNCiin in-none ActLoopNT-in 2.9246 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -5.67 APE8-rot-in 289.51 APE67-dihe-in -61.1, -22.21 -55.23, -38.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.178 0.2 A 335.0 305.0 20 29 15 14 [[11, 263]] 1.0 5ih8 Homo sapiens CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.9392 15.1461 BLAminus -123.48, 176.08 58.26, 79.91 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.7195 Saltbr-in 2.5866 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.9916 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335.0 307.0 18 29 15 14 [[11, 263]] 1.0 5ih9 Homo sapiens CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 5IHAA Q14680 3 327 651.0 6BE:60401 Type1 None DFGin 6.8292 15.0418 BLAminus -120.87, 177.4 55.95, 85.64 -102.14, 23.45 281.65, 80.18 -67.54, -28.51 in-in in 8.8421 Saltbr-in 2.6324 HRD-in -71.43, -49.46 70.45, 4.23 in-in-none SNCiin in-none ActLoopNT-in 3.0338 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.72 APE8-rot-in 296.55 APE67-dihe-in -57.19, -26.87 -59.91, -43.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.175 0.202 A 335.0 302.0 23 29 15 14 [[11, 263]] 1.0 5iha Homo sapiens CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 6GVXA Q14680 1 333 651.0 TAK:60402 Type1 None DFGin 6.711 15.2598 BLAminus -125.4, 178.58 58.73, 78.31 -98.95, 27.88 285.76, 76.62 -69.49, -24.6 in-in in 9.0037 Saltbr-in 2.9077 HRD-in -62.31, -45.72 65.24, 14.32 in-in-none SNCiin in-none ActLoopNT-in 2.8688 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -86.88 APE9-dihe-na -85.92, -154.54 APE8-dihe-in -73.43, 134.24 APE8-rot-in 297.0 APE67-dihe-in -62.55, -20.46 -61.75, -38.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.5188 APE9-dist-in 4.4863 None None None XRAY 2.24 0.205 0.24 A 344.0 311.0 15 29 22 7 [[11, 263]] 1.0 6gvx Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4BKYA Q14680 3 333 651.0 82B:1334 Type1 None DFGin 6.8606 14.7894 BLAminus -126.95, 173.05 62.71, 72.79 -92.87, 16.6 286.13, 76.41 -58.61, -28.78 in-in in 8.5922 Saltbr-in 2.5968 HRD-in -70.13, -52.15 72.52, 2.08 in-in-none SNCiin in-none ActLoopNT-in 3.0117 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -30.73 APE8-rot-in 283.32 APE67-dihe-in -55.55, -24.59 -55.8, -42.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.83 0.204 0.223 A 347.0 311.0 20 29 14 15 [[11, 263]] 1.0 4bky Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2TB Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.5171 15.4821 BLAminus -134.63, -178.27 55.46, 74.9 -94.29, 23.67 286.62, 83.25 -66.74, -35.72 in-in in 9.1486 Saltbr-in 2.7878 HRD-in -58.96, -48.62 71.55, 4.62 in-in-none SNCiin in-none ActLoopNT-in 2.8087 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -118.25 APE9-dihe-na 126.7, -132.88 APE8-dihe-in -115.61, 136.66 APE8-rot-none 999.0 APE67-dihe-in -51.25, -29.04 -60.65, -47.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.181 APE9-dist-in 3.7237 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 B 356.0 322.0 11 29 23 6 [[11, 263]] 1.0 4d2t Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2TC Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.6299 15.5937 BLAminus -134.25, 179.33 57.66, 74.82 -93.87, 24.92 285.83, 82.78 -70.22, -25.26 in-in in 9.1534 Saltbr-in 2.7964 HRD-in -57.46, -50.13 71.26, 4.63 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -131.47 APE8-dihe-in -117.46, 135.5 APE8-rot-none 999.0 APE67-dihe-in -52.13, -27.45 -60.57, -47.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6849 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 C 356.0 313.0 20 29 16 13 [[11, 263]] 1.0 4d2t Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2TD Q14680 3 333 651.0 3I7:61334 Type1 None DFGin 6.4951 15.5371 BLAminus -130.9, 164.85 58.81, 83.3 -99.74, 25.07 285.57, 83.05 -62.72, -39.18 in-in in 9.2669 Saltbr-in 2.7983 HRD-in -58.57, -49.69 71.95, 4.52 in-in-none SNCiin in-none ActLoopNT-in 2.7966 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -132.43 APE8-dihe-in -116.12, 138.43 APE8-rot-none 999.0 APE67-dihe-in -52.16, -28.22 -60.64, -47.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7327 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 D 356.0 319.0 8 29 21 8 [[11, 263]] 1.0 4d2t Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2VA Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.7918 15.7043 BLAminus -128.16, -178.54 46.67, 81.9 -94.66, 26.37 289.35, 79.84 -48.93, -31.86 in-in in 9.3877 Saltbr-in 2.8703 HRD-in -64.57, -46.97 77.06, -5.55 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.0 APE8-dihe-in -89.53, 134.8 APE8-rot-none 999.0 APE67-dihe-in -53.64, -18.08 -71.01, -44.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.5915 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 A 356.0 312.0 21 29 14 15 [[11, 263]] 1.0 4d2v Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2VC Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.7731 15.7676 BLAminus -127.7, -179.29 47.99, 81.71 -95.83, 24.05 288.88, 80.0 -69.4, -23.25 in-in in 9.3912 Saltbr-in 2.8658 HRD-in -64.65, -48.16 76.02, -3.72 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -147.18 APE8-dihe-in -89.76, 137.08 APE8-rot-none 999.0 APE67-dihe-in -54.65, -16.89 -71.35, -44.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.6099 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 C 356.0 316.0 17 29 16 13 [[11, 263]] 1.0 4d2v Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2VD Q14680 3 333 651.0 45R:61334 Type1 None DFGin 6.7572 15.6573 BLAminus -128.1, -177.36 48.27, 80.83 -95.04, 26.93 289.26, 79.87 -56.22, -36.0 in-in in 9.4377 Saltbr-in 2.8471 HRD-in -64.33, -48.39 77.06, -3.92 in-in-none SNCiin in-none ActLoopNT-in 3.3829 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.49 APE8-dihe-in -88.59, 137.31 APE8-rot-none 999.0 APE67-dihe-in -54.66, -16.96 -72.15, -45.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.6481 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 D 356.0 318.0 8 29 21 8 [[11, 263]] 1.0 4d2v Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2WC Q14680 1 333 651.0 NF5:1334 Type1 None DFGin 6.8567 15.6417 BLAminus -123.79, 178.59 60.65, 71.55 -90.39, 19.57 282.34, 80.84 -69.3, -20.74 in-in in 8.998 Saltbr-in 2.7431 HRD-in -74.38, -48.87 73.02, -0.95 in-in-none SNCiin in-none ActLoopNT-in 3.019 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.96 APE8-dihe-in -49.29, 128.09 APE8-rot-none 999.0 APE67-dihe-in -59.65, -22.66 -56.52, -44.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.7473 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 C 356.0 313.0 20 29 16 13 [[11, 263]] 1.0 4d2w Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMPD Q14680 2 333 651.0 5QM:1334 Type1 None DFGin 6.8683 15.5379 BLAminus -128.98, 172.85 60.45, 81.99 -100.97, 13.83 278.54, 87.38 -58.85, -32.32 in-in in 9.1233 Saltbr-in 2.7582 HRD-in -66.2, -47.15 69.3, -6.44 in-in-none SNCiin in-none ActLoopNT-in 2.8848 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.38 APE8-dihe-in -63.2, 133.11 APE8-rot-none 999.0 APE67-dihe-in -59.09, -26.16 -63.77, -40.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2378 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 D 356.0 321.0 7 29 22 7 [[11, 263]] 1.0 4ump Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2PA Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.7667 15.4363 BLAminus -121.57, -178.43 43.06, 87.01 -96.75, 36.15 287.09, 78.41 -62.79, -28.68 in-in in 9.8625 Saltbr-in 3.4885 HRD-in -65.09, -43.36 70.33, -2.48 in-in-none SNCiin in-none ActLoopNT-in 3.474 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.47 APE8-dihe-in -63.07, 132.76 APE8-rot-none 999.0 APE67-dihe-in -56.46, -25.28 -62.72, -43.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1304 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 A 356.0 313.0 20 29 15 14 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2PB Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.8039 15.267 BLAminus -116.15, -179.55 42.83, 87.18 -95.49, 33.61 286.93, 77.41 -73.57, -28.71 in-in in 9.6914 Saltbr-in 3.386 HRD-in -66.38, -43.95 69.75, -0.06 in-in-none SNCiin in-none ActLoopNT-in 3.1554 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -89.14 APE9-dihe-na 110.05, -162.04 APE8-dihe-in -67.8, 135.44 APE8-rot-none 999.0 APE67-dihe-in -55.82, -25.74 -63.48, -45.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.3555 APE9-dist-in 4.242 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 B 356.0 323.0 10 29 23 6 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2PC Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.7697 15.2354 BLAminus -121.44, -178.21 43.87, 86.48 -97.16, 31.68 287.92, 77.16 -71.21, -25.62 in-in in 9.5803 Saltbr-in 3.2543 HRD-in -64.88, -44.62 70.79, 0.06 in-in-none SNCiin in-none ActLoopNT-in 2.8678 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.51 APE8-dihe-in -65.31, 136.43 APE8-rot-none 999.0 APE67-dihe-in -56.72, -24.92 -63.56, -46.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.1999 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 C 356.0 315.0 18 29 16 13 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4D2PD Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.7784 15.2623 BLAminus -121.01, -179.74 44.13, 87.06 -96.7, 34.13 287.58, 76.33 -72.88, -28.13 in-in in 9.882 Saltbr-in 3.4699 HRD-in -66.46, -43.59 69.94, 0.8 in-in-none SNCiin in-none ActLoopNT-in 3.0905 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.68 APE8-dihe-in -65.17, 134.89 APE8-rot-none 999.0 APE67-dihe-in -55.96, -25.2 -65.21, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2064 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 D 356.0 317.0 7 29 22 7 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMPA Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.7782 15.2943 BLAminus -116.7, -176.8 54.54, 81.11 -105.57, 22.84 278.1, 82.0 -64.7, -26.81 in-in in 9.1873 Saltbr-in 2.7412 HRD-in -68.68, -33.57 59.29, 16.14 in-in-none SNCiin in-none ActLoopNT-in 3.4042 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.18 APE8-dihe-in -64.9, 131.94 APE8-rot-none 999.0 APE67-dihe-in -58.2, -28.41 -61.43, -40.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.9888 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 A 356.0 313.0 20 29 15 14 [[11, 263]] 1.0 4ump Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_HUMAN 4UMPC Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.8027 15.5432 BLAminus -123.91, -179.28 56.39, 85.45 -103.47, 13.92 280.5, 85.56 -60.17, -35.76 in-in in 9.0508 Saltbr-in 2.7367 HRD-in -71.35, -45.77 70.39, -10.7 in-in-none SNCiin in-none ActLoopNT-in 2.9074 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.15 APE8-dihe-in -66.96, 131.15 APE8-rot-none 999.0 APE67-dihe-in -60.1, -27.83 -60.42, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.5871 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 C 356.0 311.0 22 29 16 13 [[11, 263]] 1.0 4ump Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-87 297.7 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.7119 14.5698 BLAminus -130.6, -176.06 61.21, 74.64 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.8474 Saltbr-in 2.9578 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.4427 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334.0 308.0 17 29 17 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_MOUSE 4CQGA Q61846 2 326 643.0 OT5:61332 Type1 None DFGin 6.3125 14.1939 BLAminus -132.87, 178.1 63.59, 73.65 -97.71, 18.69 288.44, 92.66 -66.54, -24.22 in-in in 9.2103 Saltbr-in 3.0706 HRD-in -69.96, -53.3 76.88, 4.58 in-in-none SNCiin in-none ActLoopNT-in 2.9615 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 156.81 APE9-dihe-na 87.85, 175.2 APE8-dihe-in -57.99, 138.67 APE8-rot-in 288.02 APE67-dihe-in -62.14, -25.5 -62.1, -43.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.6999 APE9-dist-in 3.9099 T167E None None XRAY 2.57 0.207 0.251 A 331.0 308.0 17 29 17 12 [[11, 263]] 1.0 4cqg Mus musculus CAMK_MELK_MOUSE CAMK 3.2e-88 301.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase

CAMK_MELK (Maternal embryonic leucine zipper kinase)

Total number of chains: 2
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4BFMA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.7119 14.5698 BLAminus -130.6, -176.06 61.21, 74.64 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.8474 Saltbr-in 2.9578 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.4427 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334.0 308.0 17 29 17 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
MELK MELK_MOUSE 4CQGA Q61846 2 326 643.0 OT5:61332 Type1 None DFGin 6.3125 14.1939 BLAminus -132.87, 178.1 63.59, 73.65 -97.71, 18.69 288.44, 92.66 -66.54, -24.22 in-in in 9.2103 Saltbr-in 3.0706 HRD-in -69.96, -53.3 76.88, 4.58 in-in-none SNCiin in-none ActLoopNT-in 2.9615 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 156.81 APE9-dihe-na 87.85, 175.2 APE8-dihe-in -57.99, 138.67 APE8-rot-in 288.02 APE67-dihe-in -62.14, -25.5 -62.1, -43.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.6999 APE9-dist-in 3.9099 T167E None None XRAY 2.57 0.207 0.251 A 331.0 308.0 17 29 17 12 [[11, 263]] 1.0 4cqg Mus musculus CAMK_MELK_MOUSE CAMK 3.2e-88 301.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase