TYR_JAK1-2 (Tyrosine-protein kinase JAK1)

Total number of chains: 82
Active chains: 3
Uniprot: JAK1_HUMAN
Kinase Domain Residues: 875 - 1151
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 77 93.9% 6TPFA
DFGin BLAminus 5 6.1% AF-P23458-K2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
6C7YA 2.499 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 869 - 1153 0 PTR1035 None Tyrosine-protein kinase JAK1
AF-P23458-K2A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 867 - 1154 0 None None Tyrosine-protein kinase JAK1
AF-P23458-K4A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 867 - 1154 0 None None Tyrosine-protein kinase JAK1
5KHWA 2.47 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E4LE 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
3EYGA 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai MI1 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
3EYHA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5E1EB 2.3 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 5JG Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6AAHA 1.83 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9T6 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6AAHB 1.83 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6TPEA 2.87 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai NTW Type1 864 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6TPEB 2.87 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai NTW Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6TPFA 2.31 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai NTQ Type1 864 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6TPFB 2.31 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai NTQ Type1 865 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6GGHA 1.7 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai EYQ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6GGHB 1.7 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai EYQ Type1 863 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6ELRA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai BFK Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6ELRB 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai BFK Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6SM8B 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKT Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6SMBA 2.04 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKQ Type1 863 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6SMBB 2.04 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKQ Type1 863 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E4LA 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E4LB 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E4LD 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E4NA 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NL Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E4NB 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NL Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E5WA 1.86 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NT Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4E5WB 1.86 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NT Type1 865 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4EHZA 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 858 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4EHZB 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4EHZC 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4EHZD 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4EI4A 2.22 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0Q2 Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4EI4B 2.22 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0Q2 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4FK6A 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0UJ Type1 863 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4FK6B 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0UJ Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4I5CA 2.1 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai C5I Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4I5CB 2.1 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai C5I Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4IVBA 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J5 Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4IVBB 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J5 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4IVCA 2.35 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J6 Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4IVCB 2.35 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J6 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4IVDA 1.93 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 15T Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4IVDB 1.93 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 15T Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4K6ZA 2.73 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1Q3 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4K77A 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1Q4 Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
4K77B 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1Q4 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5HX8A 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 66P Type1 855 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5HX8B 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 66P Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5WO4A 1.84 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai B7V Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5WO4B 1.84 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai B7V Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6HZUA 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai GYQ Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6HZUB 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai GYQ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N77A 1.64 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KEJ Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N77B 1.64 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KEJ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N78A 1.83 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEP Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N79A 2.27 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KES Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N7BA 1.81 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEY Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N7CA 1.69 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai KF1 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N7CB 1.69 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai KF1 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N7DA 1.78 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KF4 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSBA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KGZ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSBB 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KGZ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSCA 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH5 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSCB 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH5 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSDA 1.76 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH8 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSDB 1.76 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH8 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSEA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSEB 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSHA 1.71 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHE Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6RSHB 1.71 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHE Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6SM8A 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKT Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
8S85A 1.75 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai A1H5R Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
8S85B 1.75 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai A1H5R Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N7AA 1.33 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEV Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6N7AB 1.33 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEV Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5KHXA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6TE Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6BBUA 2.08 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai D7D Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6DBNA 2.48 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai G4J Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
6W8LA 2.11 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R4S Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5KHWB 2.47 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1
5E1EA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 5JG Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1

TYR_JAK1-2 (Tyrosine-protein kinase JAK1)

Total number of chains: 82
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 77 93.9% 6TPFA
DFGin BLAminus 5 6.1% AF-P23458-K2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
JAK1_HUMAN 6C7YA 2.499 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 869 - 1153 0 PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN AF-P23458-K2A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 867 - 1154 0 None None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN AF-P23458-K4A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 867 - 1154 0 None None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5KHWA 2.47 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E4LE 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 3EYGA 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai MI1 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 3EYHA 2.0 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai IZA Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5E1EB 2.3 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 5JG Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6AAHA 1.83 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 9T6 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6AAHB 1.83 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 9T6 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6TPEA 2.87 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai NTW Type1 864 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6TPEB 2.87 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai NTW Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6TPFA 2.31 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai NTQ Type1 864 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6TPFB 2.31 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai NTQ Type1 865 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6GGHA 1.7 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai EYQ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6GGHB 1.7 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai EYQ Type1 863 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6ELRA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai BFK Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6ELRB 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai BFK Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6SM8B 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKT Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6SMBA 2.04 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKQ Type1 863 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6SMBB 2.04 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKQ Type1 863 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E4LA 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E4LB 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E4LD 2.0 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NH Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E4NA 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NL Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E4NB 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NL Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E5WA 1.86 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NT Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4E5WB 1.86 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0NT Type1 865 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4EHZA 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 858 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4EHZB 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4EHZC 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4EHZD 2.174 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai JAK Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4EI4A 2.22 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0Q2 Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4EI4B 2.22 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0Q2 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4FK6A 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0UJ Type1 863 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4FK6B 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 0UJ Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4I5CA 2.1 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai C5I Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4I5CB 2.1 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai C5I Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4IVBA 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J5 Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4IVBB 1.9 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J5 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4IVCA 2.35 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J6 Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4IVCB 2.35 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1J6 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4IVDA 1.93 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 15T Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4IVDB 1.93 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 15T Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4K6ZA 2.73 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1Q3 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4K77A 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1Q4 Type1 864 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 4K77B 2.4 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 1Q4 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5HX8A 2.2 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 66P Type1 855 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5HX8B 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 66P Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5WO4A 1.84 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai B7V Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5WO4B 1.84 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai B7V Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6HZUA 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai GYQ Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6HZUB 2.2 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai GYQ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N77A 1.64 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KEJ Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N77B 1.64 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KEJ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N78A 1.83 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEP Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N79A 2.27 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KES Type1 866 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N7BA 1.81 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEY Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N7CA 1.69 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai KF1 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N7CB 1.69 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_nniai APEdist_aaai KF1 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N7DA 1.78 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KF4 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSBA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KGZ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSBB 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KGZ Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSCA 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH5 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSCB 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH5 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSDA 1.76 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH8 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSDB 1.76 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KH8 Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSEA 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSEB 1.8 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHH Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSHA 1.71 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHE Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6RSHB 1.71 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai KHE Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6SM8A 1.85 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai LKT Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 8S85A 1.75 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai A1H5R Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 8S85B 1.75 Inactive DFGin‑ABAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai A1H5R Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N7AA 1.33 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEV Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6N7AB 1.33 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KEV Type1 854 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5KHXA 2.4 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6TE Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6BBUA 2.08 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai D7D Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6DBNA 2.48 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai G4J Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 6W8LA 2.11 Inactive DFGin‑ABAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai R4S Type1 867 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5KHWB 2.47 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ADP ATPlike 867 - 1153 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens
JAK1_HUMAN 5E1EA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai 5JG Type1 865 - 1154 0 PTR1034,PTR1035 None Tyrosine-protein kinase JAK1 Homo sapiens

TYR_JAK1-2 (Tyrosine-protein kinase JAK1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism