TYR_JAK1-2 (Tyrosine-protein kinase JAK1)

Total number of chains: 82
Active chains: 3
Uniprot: JAK1_HUMAN
Kinase Domain Residues: 875 - 1151
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 77 93.9% 6TPFA
DFGin BLAminus 5 6.1% AF-P23458-K2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK1-2 6C7YA P23458 869 1153 1154.0 ADP:61201 ATPlike Active DFGin 6.0323 13.967 BLAminus -134.15, -164.18 58.49, 84.96 -109.28, 28.04 298.78, 97.45 -66.39, -27.05 in-in in 8.3107 Saltbr-in 2.7325 HRD-in -67.59, -46.53 68.25, 12.43 in-in-in SNCiii in-in ActLoopNT-in 2.9437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 151.36 APE9-dihe-in -137.76, 143.32 APE8-dihe-in -74.71, 81.76 APE8-rot-na 30.49 APE67-dihe-in -79.4, -2.38 -65.2, -24.66 APE12-dist-na 12.9717 APE11-dist-na 8.0201 APE10-dist-na 10.3436 APE9-dist-in 6.3164 None PTR1035 PTR1035 XRAY 2.499 0.21 0.241 A 286.0 273.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6c7y TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 AF-P23458-K2A P23458 867 1154 1154.0 No_ligand No_ligand Active DFGin 6.307 13.7726 BLAminus -130.0, -171.31 51.92, 79.2 -91.39, 17.47 288.09, 81.21 -63.19, -25.32 in-in in 8.0857 Saltbr-in 2.7191 HRD-in -67.76, -41.14 64.22, -10.98 in-in-in SNCiii in-in ActLoopNT-in 2.9399 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.83, 123.48 APE9-dihe-in -125.8, 136.55 APE8-dihe-in -75.77, 67.19 APE8-rot-na 34.45 APE67-dihe-in -77.12, -11.68 -54.83, -26.9 APE12-dist-na 13.9103 APE11-dist-na 8.5318 APE10-dist-na 10.6595 APE9-dist-in 7.0627 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 31 31 0 [[583, 847], [875, 1151]] 2.0 AF-P23458-K2 TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 AF-P23458-K4A P23458 867 1154 1154.0 No_ligand No_ligand Active DFGin 6.0337 13.5522 BLAminus -127.94, -176.44 52.21, 91.21 -99.55, 15.91 293.58, 76.0 -63.9, -24.71 in-in in 7.8098 Saltbr-in 2.7151 HRD-in -69.66, -43.24 62.91, -1.77 in-in-in SNCiii in-in ActLoopNT-in 2.9198 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -47.59, 114.14 APE9-dihe-in -120.02, 146.94 APE8-dihe-in -73.57, 63.93 APE8-rot-na 37.51 APE67-dihe-in -76.35, -14.96 -54.26, -27.82 APE12-dist-na 13.6974 APE11-dist-na 8.1142 APE10-dist-na 10.9163 APE9-dist-in 6.7347 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 31 31 0 [[583, 847], [875, 1151]] 2.0 AF-P23458-K4 TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5KHWA P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.2929 13.5952 ABAminus -113.62, -36.19 -113.51, 112.49 -104.48, 28.51 302.05, 98.46 -68.45, -35.55 in-in in 8.0172 Saltbr-in 2.8107 HRD-in -53.69, -54.55 74.32, 4.71 in-in-in SNCiii in-in ActLoopNT-in 2.8167 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.25, 151.86 APE9-dihe-in -139.19, 145.92 APE8-dihe-in -78.07, 75.73 APE8-rot-na 29.65 APE67-dihe-in -77.72, -3.4 -55.44, -31.5 APE12-dist-na 13.0141 APE11-dist-na 7.3323 APE10-dist-na 9.9045 APE9-dist-in 6.0223 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 A 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E4LE P23458 864 1154 1154.0 No_ligand No_ligand Inactive DFGin 6.4627 13.613 ABAminus -114.05, 7.25 -155.92, 142.83 -135.92, 30.26 296.52, 85.61 -59.94, -28.28 in-in in 7.8702 Saltbr-in 2.6251 HRD-in -76.43, -49.33 70.91, 5.03 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.8, 27.83 APE9-dihe-in -58.48, 132.7 APE8-dihe-in -75.95, 78.2 APE8-rot-na 25.62 APE67-dihe-in -75.39, -5.67 -60.62, -30.34 APE12-dist-na 11.4043 APE11-dist-na 12.8654 APE10-dist-na 10.3351 APE9-dist-in 6.7659 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 E 302.0 282.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 3EYGA P23458 865 1154 1154.0 MI1:1 Type1 Inactive DFGin 6.4845 13.5855 ABAminus -124.32, 8.36 -155.42, 148.92 -141.71, 28.09 295.61, 92.98 -69.61, -22.8 in-in in 7.7723 Saltbr-in 2.8707 HRD-in -73.25, -48.81 76.52, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.1, 4.52 APE9-dihe-in -69.5, 129.84 APE8-dihe-in -77.86, 81.49 APE8-rot-na 30.22 APE67-dihe-in -79.56, -5.41 -59.51, -27.49 APE12-dist-na 10.7554 APE11-dist-na 11.0552 APE10-dist-na 6.7069 APE9-dist-in 5.5949 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.171 0.214 A 290.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 3eyg TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 3EYHA P23458 865 1154 1154.0 IZA:2001 Type1 Inactive DFGin 6.7108 13.7777 ABAminus -123.79, 5.59 -151.26, 147.61 -137.78, 30.19 296.78, 89.6 -63.64, -28.15 in-in in 7.7407 Saltbr-in 2.8801 HRD-in -74.82, -42.99 68.23, 5.73 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -136.22, 60.46 APE9-dihe-in -76.43, 138.22 APE8-dihe-in -79.32, 79.81 APE8-rot-na 29.32 APE67-dihe-in -73.68, -7.92 -57.92, -30.28 APE12-dist-na 10.347 APE11-dist-na 10.9945 APE10-dist-na 9.0512 APE9-dist-in 5.5722 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.178 0.237 A 290.0 287.0 3 31 31 0 [[583, 847], [875, 1151]] 2.0 3eyh TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5E1EB P23458 865 1154 1154.0 5JG:1201 Type1 Inactive DFGin 6.6155 13.7027 ABAminus -133.31, 28.19 -149.71, 114.81 -114.53, 26.1 291.32, 84.42 -63.72, -24.05 in-in in 7.7649 Saltbr-in 2.7841 HRD-in -74.91, -42.75 64.28, 0.85 in-in-out SNCiio in-out ActLoopNT-in 2.8012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.64, 38.4 APE9-dihe-in -74.25, 132.21 APE8-dihe-in -79.08, 75.2 APE8-rot-na 22.34 APE67-dihe-in -75.56, -2.49 -52.66, -36.06 APE12-dist-na 10.8574 APE11-dist-na 13.3108 APE10-dist-na 10.0385 APE9-dist-in 6.8736 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 B 290.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6AAHA P23458 865 1154 1154.0 9T6:1201 Type1 Inactive DFGin 6.3189 13.4568 ABAminus -111.86, -1.07 -147.59, 142.74 -130.77, 31.7 296.21, 81.89 -59.29, -31.87 in-in in 7.8369 Saltbr-in 2.7851 HRD-in -79.04, -51.9 74.79, 8.24 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.78, 24.87 APE9-dihe-in -65.36, 146.43 APE8-dihe-in -84.69, 80.23 APE8-rot-na 32.65 APE67-dihe-in -73.6, -4.54 -60.24, -33.63 APE12-dist-na 10.5006 APE11-dist-na 13.0658 APE10-dist-na 9.9007 APE9-dist-in 6.4221 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.83 0.225 0.255 A 290.0 285.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 6aah TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6AAHB P23458 865 1154 1154.0 9T6:1201 Type1 Inactive DFGin 6.4616 13.5876 ABAminus -114.68, 9.66 -151.81, 133.96 -131.35, 23.59 291.95, 87.28 -61.54, -23.21 in-in in 8.0413 Saltbr-in 2.6139 HRD-in -74.7, -48.84 74.08, 5.49 in-in-in SNCiii in-in ActLoopNT-in 2.7826 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.14, 67.65 APE9-dihe-in -109.05, 132.69 APE8-dihe-in -79.19, 76.3 APE8-rot-na 35.14 APE67-dihe-in -76.24, -3.1 -57.7, -33.14 APE12-dist-na 10.1909 APE11-dist-na 12.4612 APE10-dist-na 9.1413 APE9-dist-in 6.5428 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.83 0.225 0.255 B 290.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6aah TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6TPEA P23458 864 1153 1154.0 NTW:1201 Type1 Inactive DFGin 6.4521 13.4517 ABAminus -113.52, 27.97 -159.85, 137.75 -139.89, 37.69 300.95, 90.85 -70.73, -32.53 in-in in 7.9845 Saltbr-in 2.8979 HRD-in -77.39, -48.43 67.11, 20.0 in-in-in SNCiii in-in ActLoopNT-in 2.7214 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.39, 82.51 APE9-dihe-in -109.84, 138.7 APE8-dihe-in -71.54, 85.2 APE8-rot-na 346.93 APE67-dihe-in -79.64, -10.25 -64.68, -30.27 APE12-dist-na 10.1252 APE11-dist-na 12.1296 APE10-dist-na 10.4977 APE9-dist-in 6.4525 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.87 0.249 0.298 A 291.0 283.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpe TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6TPEB P23458 864 1154 1154.0 NTW:1201 Type1 Inactive DFGin 6.4487 13.4616 ABAminus -113.4, 27.83 -159.97, 137.64 -139.8, 37.79 300.87, 90.88 -70.61, -32.51 in-in in 7.9939 Saltbr-in 2.8934 HRD-in -77.28, -48.49 67.12, 19.91 in-in-in SNCiii in-in ActLoopNT-in 2.7232 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.48, 82.82 APE9-dihe-in -109.8, 138.58 APE8-dihe-in -71.3, 85.03 APE8-rot-na 346.96 APE67-dihe-in -79.6, -10.33 -64.53, -30.29 APE12-dist-na 10.1332 APE11-dist-na 12.1297 APE10-dist-na 10.5127 APE9-dist-in 6.4531 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.87 0.249 0.298 B 291.0 283.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpe TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6TPFA P23458 864 1153 1154.0 NTQ:1201 Type1 Inactive DFGin 6.5489 13.5659 ABAminus -112.13, 4.42 -147.17, 134.74 -132.51, 36.57 297.52, 87.9 -61.56, -38.59 in-in in 7.9072 Saltbr-in 2.7233 HRD-in -81.26, -43.5 66.58, 8.45 in-in-out SNCiio in-out ActLoopNT-in 2.7552 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.97, 47.61 APE9-dihe-in -75.75, 153.17 APE8-dihe-in -82.59, 85.83 APE8-rot-na 32.54 APE67-dihe-in -74.51, -8.6 -66.85, -35.11 APE12-dist-na 10.9508 APE11-dist-na 12.7019 APE10-dist-na 10.9448 APE9-dist-in 6.7022 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.31 0.266 0.327 A 291.0 288.0 2 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpf TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6TPFB P23458 865 1153 1154.0 NTQ:1201 Type1 Inactive DFGin 6.5159 13.6075 ABAminus -112.38, 6.69 -146.72, 134.6 -130.81, 35.94 297.58, 85.61 -65.62, -37.25 in-in in 7.8432 Saltbr-in 2.7199 HRD-in -83.36, -42.45 66.49, 9.9 in-in-out SNCiio in-out ActLoopNT-in 2.7624 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 46.13, 45.8 APE9-dihe-in -71.68, 152.43 APE8-dihe-in -82.66, 85.94 APE8-rot-na 32.5 APE67-dihe-in -74.85, -9.43 -66.05, -35.76 APE12-dist-na 10.9678 APE11-dist-na 12.3423 APE10-dist-na 11.4191 APE9-dist-in 6.666 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.31 0.266 0.327 B 291.0 278.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpf TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6GGHA P23458 865 1154 1154.0 EYQ:1201 Type1 Inactive DFGin 6.4736 13.7082 ABAminus -120.02, -5.29 -148.47, 136.5 -125.28, 25.35 294.61, 85.16 -56.12, -34.28 in-in in 7.7182 Saltbr-in 2.5913 HRD-in -74.74, -47.68 65.51, 13.25 in-in-out SNCiio in-out ActLoopNT-in 2.7664 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 52.1, 57.9 APE9-dihe-in -80.13, 145.81 APE8-dihe-in -79.99, 78.75 APE8-rot-na 31.21 APE67-dihe-in -74.16, -4.73 -59.55, -32.45 APE12-dist-na 10.1051 APE11-dist-na 9.8842 APE10-dist-na 9.9812 APE9-dist-in 6.1057 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.7 0.192 0.262 A 292.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6ggh TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6GGHB P23458 863 1154 1154.0 EYQ:1201 Type1 Inactive DFGin 6.3928 13.8854 ABAminus -111.86, -4.02 -150.16, 140.27 -128.87, 25.84 291.88, 86.63 -62.88, -36.22 in-in in 7.7947 Saltbr-in 2.5918 HRD-in -72.53, -48.04 68.9, 11.02 in-in-out SNCiio in-out ActLoopNT-in 2.7893 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 72.16, 30.7 APE9-dihe-in -88.91, 131.65 APE8-dihe-in -78.72, 80.52 APE8-rot-na 31.53 APE67-dihe-in -73.31, -5.76 -61.33, -30.45 APE12-dist-na 10.2866 APE11-dist-na 10.6521 APE10-dist-na 8.3392 APE9-dist-in 5.9942 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.7 0.192 0.262 B 292.0 282.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6ggh TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6ELRA P23458 854 1154 1154.0 BFK:1201 Type1 Inactive DFGin 6.5967 13.5994 ABAminus -108.66, 4.92 -152.97, 140.13 -131.61, 26.62 294.97, 83.84 -57.45, -30.06 in-in in 7.7786 Saltbr-in 2.7415 HRD-in -71.99, -47.83 69.61, 1.99 in-in-out SNCiio in-out ActLoopNT-in 2.831 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.35, 32.0 APE9-dihe-in -64.21, 131.29 APE8-dihe-in -79.64, 72.85 APE8-rot-na 28.8 APE67-dihe-in -76.69, -6.06 -50.77, -33.65 APE12-dist-na 10.934 APE11-dist-na 12.9294 APE10-dist-na 9.9193 APE9-dist-in 6.8377 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.182 0.205 A 301.0 289.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6elr TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6ELRB P23458 865 1154 1154.0 BFK:1201 Type1 Inactive DFGin 6.6014 13.5309 ABAminus -109.26, 5.99 -154.04, 139.83 -131.25, 27.64 294.03, 83.78 -58.7, -28.76 in-in in 7.7388 Saltbr-in 2.7522 HRD-in -72.31, -47.94 70.47, 1.78 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.07, 32.45 APE9-dihe-in -65.92, 131.99 APE8-dihe-in -78.37, 73.16 APE8-rot-na 28.72 APE67-dihe-in -77.26, -5.72 -51.85, -33.17 APE12-dist-na 11.0567 APE11-dist-na 13.1477 APE10-dist-na 10.0689 APE9-dist-in 6.8534 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.182 0.205 B 301.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6elr TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6SM8B P23458 865 1154 1154.0 LKT:61201 Type1 Inactive DFGin 6.8061 13.6678 ABAminus -102.82, -5.52 -148.54, 142.3 -131.39, 24.74 291.91, 87.01 -56.81, -29.39 in-in in 7.8014 Saltbr-in 2.7112 HRD-in -72.52, -51.3 71.87, 8.95 in-in-out SNCiio in-out ActLoopNT-in 2.8319 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.32, 29.21 APE9-dihe-in -64.29, 137.39 APE8-dihe-in -82.59, 73.84 APE8-rot-na 28.56 APE67-dihe-in -76.5, -2.32 -51.19, -31.92 APE12-dist-na 11.5209 APE11-dist-na 13.3431 APE10-dist-na 10.3287 APE9-dist-in 6.6704 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.213 0.241 B 301.0 284.0 6 31 29 2 [[583, 847], [875, 1151]] 2.0 6sm8 TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6SMBA P23458 863 1153 1154.0 LKQ:1201 Type1 Inactive DFGin 6.6066 13.7308 ABAminus -104.09, 12.38 -161.47, 134.46 -125.84, 26.47 298.3, 80.99 -58.62, -24.17 in-in in 7.8314 Saltbr-in 2.6426 HRD-in -73.47, -45.53 65.45, 5.36 in-in-out SNCiio in-out ActLoopNT-in 2.7488 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.53, 41.14 APE9-dihe-in -70.01, 131.09 APE8-dihe-in -75.02, 72.06 APE8-rot-na 25.33 APE67-dihe-in -73.28, -2.79 -51.04, -36.86 APE12-dist-na 12.0201 APE11-dist-na 12.7163 APE10-dist-na 10.2351 APE9-dist-in 6.7545 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.04 0.224 0.265 A 301.0 288.0 3 31 31 0 [[583, 847], [875, 1151]] 2.0 6smb TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6SMBB P23458 863 1153 1154.0 LKQ:1201 Type1 Inactive DFGin 6.6183 13.8112 ABAminus -106.29, 15.46 -163.61, 135.62 -126.74, 26.38 298.65, 81.43 -58.83, -23.63 in-in in 7.8691 Saltbr-in 2.6267 HRD-in -72.91, -46.19 66.2, 3.06 in-in-out SNCiio in-out ActLoopNT-in 2.7449 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 76.78, 22.71 APE9-dihe-in -68.31, 133.01 APE8-dihe-in -75.13, 72.89 APE8-rot-na 25.36 APE67-dihe-in -72.9, -3.33 -50.86, -36.85 APE12-dist-na 10.8308 APE11-dist-na 12.5749 APE10-dist-na 10.4555 APE9-dist-in 6.6799 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.04 0.224 0.265 B 301.0 282.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6smb TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E4LA P23458 865 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5059 13.5932 ABAminus -113.26, 1.55 -155.7, 141.31 -133.96, 30.85 296.7, 84.55 -61.93, -29.15 in-in in 7.7283 Saltbr-in 2.3665 HRD-in -82.62, -51.73 77.35, 2.42 in-in-out SNCiio in-out ActLoopNT-in 2.8326 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.62, 29.91 APE9-dihe-in -55.83, 134.62 APE8-dihe-in -77.55, 77.11 APE8-rot-na 23.92 APE67-dihe-in -76.85, -4.17 -58.31, -32.93 APE12-dist-na 11.099 APE11-dist-na 12.7606 APE10-dist-na 10.3479 APE9-dist-in 6.603 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 A 302.0 279.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E4LB P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.4683 13.6897 ABAminus -115.34, 5.94 -154.23, 143.98 -136.31, 29.8 294.89, 85.73 -63.4, -28.12 in-in in 7.872 Saltbr-in 2.6248 HRD-in -80.23, -45.9 70.61, 1.75 in-in-out SNCiio in-out ActLoopNT-in 2.7501 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.56, 32.84 APE9-dihe-in -59.39, 139.65 APE8-dihe-in -81.36, 75.53 APE8-rot-na 28.93 APE67-dihe-in -77.55, -4.05 -62.31, -27.51 APE12-dist-na 10.9946 APE11-dist-na 12.667 APE10-dist-na 10.0695 APE9-dist-in 6.6324 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 B 302.0 281.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E4LD P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5361 13.748 ABAminus -114.27, -0.81 -153.61, 143.22 -135.12, 28.03 293.73, 85.38 -57.66, -27.04 in-in in 7.7412 Saltbr-in 2.5547 HRD-in -77.01, -53.08 75.86, 4.71 in-in-out SNCiio in-out ActLoopNT-in 2.8229 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.68, 33.68 APE9-dihe-in -65.48, 130.64 APE8-dihe-in -74.63, 79.76 APE8-rot-na 26.43 APE67-dihe-in -75.57, -2.67 -62.18, -32.34 APE12-dist-na 11.5127 APE11-dist-na 12.875 APE10-dist-na 10.4155 APE9-dist-in 6.7005 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 D 302.0 283.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E4NA P23458 854 1154 1154.0 0NL:61201 Type1 Inactive DFGin 6.3841 13.5599 ABAminus -120.02, 11.21 -158.48, 139.99 -136.43, 26.78 297.09, 85.57 -63.39, -21.4 in-in in 7.7905 Saltbr-in 2.5546 HRD-in -80.31, -49.85 72.5, 4.9 in-in-out SNCiio in-out ActLoopNT-in 2.8478 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.76, 48.8 APE9-dihe-in -75.99, 139.57 APE8-dihe-in -78.93, 73.17 APE8-rot-na 33.7 APE67-dihe-in -74.47, -3.41 -60.94, -30.72 APE12-dist-na 11.0707 APE11-dist-na 12.7564 APE10-dist-na 10.411 APE9-dist-in 6.8318 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.226 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4n TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E4NB P23458 865 1154 1154.0 0NL:61201 Type1 Inactive DFGin 6.3464 13.5023 ABAminus -119.9, 9.63 -155.68, 139.61 -133.8, 28.11 297.19, 80.43 -62.66, -24.74 in-in in 7.7373 Saltbr-in 2.6034 HRD-in -78.32, -48.47 74.25, 0.38 in-in-out SNCiio in-out ActLoopNT-in 2.8745 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.54, 49.17 APE9-dihe-in -76.21, 142.06 APE8-dihe-in -79.22, 71.62 APE8-rot-na 25.59 APE67-dihe-in -77.0, -5.97 -60.76, -27.4 APE12-dist-na 11.1624 APE11-dist-na 12.7927 APE10-dist-na 10.4333 APE9-dist-in 6.9387 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.226 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4n TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E5WA P23458 854 1154 1154.0 0NT:61201 Type1 Inactive DFGin 6.562 13.397 ABAminus -118.14, 5.18 -153.89, 137.32 -129.51, 26.76 295.21, 88.69 -58.94, -26.21 in-in in 7.7041 Saltbr-in 2.6868 HRD-in -73.36, -50.75 70.96, 2.6 in-in-out SNCiio in-out ActLoopNT-in 2.8337 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.84, 26.34 APE9-dihe-in -57.31, 135.68 APE8-dihe-in -78.98, 72.49 APE8-rot-na 27.03 APE67-dihe-in -72.09, -3.1 -47.71, -39.24 APE12-dist-na 11.0884 APE11-dist-na 13.5699 APE10-dist-na 10.4497 APE9-dist-in 6.7378 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.86 0.184 0.21 A 302.0 293.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e5w TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4E5WB P23458 865 1153 1154.0 0NT:61202 Type1 Inactive DFGin 6.5301 13.3501 ABAminus -114.8, 7.46 -153.87, 137.96 -129.8, 26.64 296.41, 93.24 -58.91, -27.51 in-in in 7.6911 Saltbr-in 2.6865 HRD-in -74.04, -50.94 71.65, 3.46 in-in-out SNCiio in-out ActLoopNT-in 2.8325 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.41, 26.14 APE9-dihe-in -57.59, 134.48 APE8-dihe-in -78.71, 72.64 APE8-rot-na 26.79 APE67-dihe-in -72.94, -2.19 -48.23, -38.49 APE12-dist-na 11.1134 APE11-dist-na 13.5566 APE10-dist-na 10.4312 APE9-dist-in 6.7576 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.86 0.184 0.21 B 302.0 280.0 9 31 29 2 [[583, 847], [875, 1151]] 2.0 4e5w TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4EHZA P23458 858 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.2945 13.63 ABAminus -122.46, 12.74 -158.91, 149.59 -139.33, 23.83 295.89, 89.08 -61.4, -20.25 in-in in 7.7955 Saltbr-in 2.9362 HRD-in -79.41, -51.26 80.05, -0.3 in-in-out SNCiio in-out ActLoopNT-in 2.8662 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.49, 24.25 APE9-dihe-in -61.79, 133.39 APE8-dihe-in -76.86, 73.91 APE8-rot-na 30.52 APE67-dihe-in -75.94, -6.94 -60.76, -27.83 APE12-dist-na 11.4383 APE11-dist-na 13.1596 APE10-dist-na 9.8707 APE9-dist-in 7.0319 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 A 302.0 292.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4EHZB P23458 865 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.3175 13.7298 ABAminus -116.35, 3.51 -150.61, 148.16 -138.87, 32.34 292.95, 86.02 -67.41, -23.21 in-in in 7.8685 Saltbr-in 2.7634 HRD-in -83.57, -44.01 70.15, -1.08 in-in-out SNCiio in-out ActLoopNT-in 2.7334 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.9, 29.19 APE9-dihe-in -67.89, 136.88 APE8-dihe-in -75.68, 68.81 APE8-rot-na 33.04 APE67-dihe-in -71.9, -6.58 -49.99, -36.99 APE12-dist-na 11.4195 APE11-dist-na 13.393 APE10-dist-na 10.1247 APE9-dist-in 6.9909 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4EHZC P23458 866 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.3172 13.6208 ABAminus -118.15, 8.14 -148.22, 154.09 -141.74, 25.14 292.74, 84.54 -60.05, -18.24 in-in in 7.8585 Saltbr-in 2.8403 HRD-in -77.85, -48.09 78.3, 3.1 in-in-out SNCiio in-out ActLoopNT-in 2.7238 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.81, 30.11 APE9-dihe-in -57.01, 145.43 APE8-dihe-in -85.32, 74.95 APE8-rot-na 31.15 APE67-dihe-in -74.27, -3.28 -56.74, -31.49 APE12-dist-na 10.9751 APE11-dist-na 13.0044 APE10-dist-na 10.1803 APE9-dist-in 6.676 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 C 302.0 280.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4EHZD P23458 865 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.4285 13.533 ABAminus -123.86, 16.47 -158.34, 146.22 -137.38, 32.15 296.06, 77.8 -67.83, -20.15 in-in in 7.6786 Saltbr-in 2.9996 HRD-in -85.88, -43.73 70.18, 7.9 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.38, 26.48 APE9-dihe-in -59.77, 138.32 APE8-dihe-in -81.72, 74.58 APE8-rot-na 32.67 APE67-dihe-in -77.67, -4.82 -52.47, -31.56 APE12-dist-na 11.0435 APE11-dist-na 12.9621 APE10-dist-na 10.0088 APE9-dist-in 6.6881 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 D 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4EI4A P23458 854 1154 1154.0 0Q2:61201 Type1 Inactive DFGin 6.3615 13.4524 ABAminus -125.08, 21.55 -162.93, 136.7 -132.47, 29.54 298.16, 82.51 -65.62, -22.07 in-in in 7.843 Saltbr-in 2.6125 HRD-in -82.16, -48.37 72.58, 5.29 in-in-out SNCiio in-out ActLoopNT-in 2.7441 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.53, 42.94 APE9-dihe-in -71.49, 136.49 APE8-dihe-in -77.62, 74.63 APE8-rot-na 31.88 APE67-dihe-in -76.69, -5.39 -62.91, -28.92 APE12-dist-na 10.9829 APE11-dist-na 12.7533 APE10-dist-na 10.2586 APE9-dist-in 6.7838 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.22 0.202 0.239 A 302.0 290.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 4ei4 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4EI4B P23458 865 1154 1154.0 0Q2:61201 Type1 Inactive DFGin 6.3821 13.5185 ABAminus -120.19, 16.13 -160.02, 140.78 -136.52, 31.88 292.39, 84.5 -65.63, -28.61 in-in in 7.8532 Saltbr-in 2.8267 HRD-in -84.06, -46.22 68.02, 6.16 in-in-out SNCiio in-out ActLoopNT-in 2.7517 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.4, 38.28 APE9-dihe-in -67.47, 135.5 APE8-dihe-in -75.19, 75.25 APE8-rot-na 28.78 APE67-dihe-in -75.9, -4.89 -57.78, -34.83 APE12-dist-na 11.0547 APE11-dist-na 12.6874 APE10-dist-na 10.2359 APE9-dist-in 6.7889 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.22 0.202 0.239 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ei4 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4FK6A P23458 863 1154 1154.0 0UJ:1201 Type1 Inactive DFGin 6.5774 13.4134 ABAminus -112.19, 2.74 -147.97, 135.94 -128.79, 22.38 293.74, 90.76 -52.95, -29.36 in-in in 7.654 Saltbr-in 2.6738 HRD-in -73.71, -49.95 70.6, -2.02 in-in-out SNCiio in-out ActLoopNT-in 2.8101 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.7, 28.56 APE9-dihe-in -63.18, 134.95 APE8-dihe-in -78.74, 77.08 APE8-rot-na 27.11 APE67-dihe-in -76.1, -2.34 -51.26, -33.75 APE12-dist-na 11.3197 APE11-dist-na 12.8559 APE10-dist-na 10.101 APE9-dist-in 6.6455 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.211 0.251 A 302.0 287.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 4fk6 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4FK6B P23458 864 1154 1154.0 0UJ:1201 Type1 Inactive DFGin 6.5944 13.4059 ABAminus -112.12, 2.82 -147.85, 135.79 -128.94, 22.08 293.63, 90.77 -52.49, -30.06 in-in in 7.6382 Saltbr-in 2.6795 HRD-in -73.35, -50.23 70.8, -1.92 in-in-out SNCiio in-out ActLoopNT-in 2.8173 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.94, 28.16 APE9-dihe-in -62.61, 135.05 APE8-dihe-in -78.72, 77.07 APE8-rot-na 27.01 APE67-dihe-in -76.01, -2.17 -51.54, -33.82 APE12-dist-na 11.3135 APE11-dist-na 12.766 APE10-dist-na 10.1407 APE9-dist-in 6.6468 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.211 0.251 B 302.0 286.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 4fk6 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4I5CA P23458 865 1154 1154.0 C5I:61201 Type1 Inactive DFGin 6.372 13.0985 ABAminus -114.74, 13.12 -159.95, 138.51 -132.46, 27.57 300.19, 86.09 -57.95, -29.46 in-in in 7.6484 Saltbr-in 2.6628 HRD-in -72.51, -44.79 66.5, 0.54 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -124.02, 33.91 APE9-dihe-in -66.46, 131.24 APE8-dihe-in -75.55, 75.28 APE8-rot-na 31.15 APE67-dihe-in -75.41, -9.49 -50.0, -34.68 APE12-dist-na 11.2602 APE11-dist-na 13.3407 APE10-dist-na 10.1945 APE9-dist-in 6.774 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.1 0.193 0.245 A 302.0 281.0 9 31 30 1 [[583, 847], [875, 1151]] 2.0 4i5c TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4I5CB P23458 854 1154 1154.0 C5I:61205 Type1 Inactive DFGin 6.2884 13.0623 ABAminus -117.66, 20.22 -158.68, 137.22 -131.37, 22.03 299.16, 87.56 -52.78, -31.38 in-in in 7.784 Saltbr-in 2.5861 HRD-in -74.37, -52.31 71.43, 0.95 in-in-out SNCiio in-out ActLoopNT-in 2.9476 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.41, 21.23 APE9-dihe-in -58.7, 133.33 APE8-dihe-in -78.45, 70.87 APE8-rot-na 28.87 APE67-dihe-in -73.75, -3.17 -47.7, -37.18 APE12-dist-na 11.1462 APE11-dist-na 13.1938 APE10-dist-na 10.0316 APE9-dist-in 6.8402 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.1 0.193 0.245 B 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4i5c TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4IVBA P23458 854 1154 1154.0 1J5:61201 Type1 Inactive DFGin 6.4461 13.3982 ABAminus -120.37, 8.79 -154.43, 145.03 -134.59, 25.95 296.41, 85.72 -59.41, -26.27 in-in in 7.7771 Saltbr-in 2.6073 HRD-in -81.27, -49.76 73.46, 5.83 in-in-out SNCiio in-out ActLoopNT-in 2.9009 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.65, 36.69 APE9-dihe-in -67.09, 139.5 APE8-dihe-in -78.95, 74.88 APE8-rot-na 31.26 APE67-dihe-in -75.42, -5.51 -58.71, -32.55 APE12-dist-na 11.2148 APE11-dist-na 12.9349 APE10-dist-na 10.3112 APE9-dist-in 6.7806 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.221 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivb TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4IVBB P23458 865 1154 1154.0 1J5:61201 Type1 Inactive DFGin 6.4294 13.4146 ABAminus -116.62, 7.74 -154.57, 143.33 -132.65, 26.65 294.75, 85.72 -57.0, -32.17 in-in in 7.7125 Saltbr-in 2.6507 HRD-in -82.29, -46.68 69.34, 6.53 in-in-out SNCiio in-out ActLoopNT-in 2.8948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.2, 32.35 APE9-dihe-in -63.44, 138.0 APE8-dihe-in -78.25, 77.26 APE8-rot-na 32.13 APE67-dihe-in -75.77, -2.93 -62.98, -29.79 APE12-dist-na 11.2627 APE11-dist-na 12.9835 APE10-dist-na 10.306 APE9-dist-in 6.7691 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.221 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivb TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4IVCA P23458 854 1154 1154.0 1J6:61201 Type1 Inactive DFGin 6.2486 13.2512 ABAminus -114.51, 9.81 -157.21, 145.73 -138.3, 37.36 304.45, 81.48 -64.22, -30.51 in-in in 7.8262 Saltbr-in 2.6917 HRD-in -91.76, -42.16 67.22, -0.09 in-in-out SNCiio in-out ActLoopNT-in 2.8419 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.76, 45.97 APE9-dihe-in -72.9, 142.32 APE8-dihe-in -77.97, 76.61 APE8-rot-na 30.79 APE67-dihe-in -73.52, -3.32 -54.87, -39.45 APE12-dist-na 11.1918 APE11-dist-na 12.6517 APE10-dist-na 10.1709 APE9-dist-in 6.5489 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.35 0.2 0.263 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivc TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4IVCB P23458 865 1154 1154.0 1J6:61201 Type1 Inactive DFGin 6.3131 13.3466 ABAminus -119.67, 6.43 -149.04, 145.44 -134.49, 29.55 297.17, 82.22 -60.5, -32.79 in-in in 7.5246 Saltbr-in 2.2767 HRD-in -89.31, -45.09 71.21, 3.65 in-in-out SNCiio in-out ActLoopNT-in 2.7171 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.71, 20.54 APE9-dihe-in -65.21, 135.06 APE8-dihe-in -79.05, 83.59 APE8-rot-na 28.99 APE67-dihe-in -78.13, -7.38 -62.67, -27.87 APE12-dist-na 11.123 APE11-dist-na 12.804 APE10-dist-na 9.574 APE9-dist-in 6.6074 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.35 0.2 0.263 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivc TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4IVDA P23458 854 1154 1154.0 15T:61201 Type1 Inactive DFGin 6.3094 13.3038 ABAminus -118.43, 8.35 -154.11, 148.17 -137.65, 24.48 298.46, 83.68 -55.12, -27.34 in-in in 7.7486 Saltbr-in 2.7286 HRD-in -85.26, -46.42 71.64, 5.83 in-in-out SNCiio in-out ActLoopNT-in 2.9031 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.71, 33.92 APE9-dihe-in -63.4, 140.18 APE8-dihe-in -80.26, 75.71 APE8-rot-na 32.55 APE67-dihe-in -74.69, -4.74 -58.39, -31.37 APE12-dist-na 11.2468 APE11-dist-na 12.9702 APE10-dist-na 10.2675 APE9-dist-in 6.6549 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.93 0.204 0.247 A 302.0 291.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivd TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4IVDB P23458 865 1154 1154.0 15T:61201 Type1 Inactive DFGin 6.4106 13.3698 ABAminus -112.55, 2.72 -159.22, 144.81 -135.21, 28.45 296.48, 84.97 -57.15, -29.77 in-in in 7.6756 Saltbr-in 2.7452 HRD-in -84.66, -44.43 68.53, 7.81 in-in-out SNCiio in-out ActLoopNT-in 2.9218 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.94, 35.04 APE9-dihe-in -66.46, 139.38 APE8-dihe-in -79.29, 77.36 APE8-rot-na 30.63 APE67-dihe-in -76.81, -5.82 -62.53, -27.62 APE12-dist-na 11.2208 APE11-dist-na 12.9738 APE10-dist-na 10.2444 APE9-dist-in 6.6658 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.93 0.204 0.247 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivd TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4K6ZA P23458 865 1154 1154.0 1Q3:1201 Type1 Inactive DFGin 6.3683 13.6285 ABAminus -111.25, 5.81 -148.16, 138.39 -130.89, 30.06 299.5, 88.49 -54.29, -32.58 in-in in 8.1614 Saltbr-in 2.9135 HRD-in -64.09, -54.55 67.8, 5.15 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.94, 36.35 APE9-dihe-in -67.0, 125.07 APE8-dihe-in -75.83, 85.59 APE8-rot-na 25.89 APE67-dihe-in -67.06, -19.07 -53.74, -42.35 APE12-dist-na 10.4253 APE11-dist-na 12.5827 APE10-dist-na 10.0067 APE9-dist-in 6.0159 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.73 0.244 0.297 A 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4k6z TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4K77A P23458 864 1154 1154.0 1Q4:1201 Type1 Inactive DFGin 6.2559 13.4641 ABAminus -120.21, 6.98 -152.33, 140.1 -135.8, 29.32 300.23, 84.02 -66.83, -17.3 in-in in 8.0423 Saltbr-in 2.62 HRD-in -83.59, -46.77 75.55, -1.36 in-in-out SNCiio in-out ActLoopNT-in 2.8065 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.78, 30.95 APE9-dihe-in -65.86, 137.27 APE8-dihe-in -79.1, 74.56 APE8-rot-na 31.39 APE67-dihe-in -73.63, -7.17 -57.69, -30.82 APE12-dist-na 11.1803 APE11-dist-na 12.7953 APE10-dist-na 9.921 APE9-dist-in 6.7505 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.4 0.193 0.251 A 302.0 284.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 4k77 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 4K77B P23458 865 1154 1154.0 1Q4:1201 Type1 Inactive DFGin 6.2823 13.5037 ABAminus -120.68, 0.99 -147.42, 142.05 -133.88, 36.74 297.84, 83.5 -67.02, -18.72 in-in in 7.9484 Saltbr-in 2.9218 HRD-in -85.03, -50.83 74.8, -3.74 in-in-out SNCiio in-out ActLoopNT-in 2.726 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.68, 47.05 APE9-dihe-in -77.0, 143.68 APE8-dihe-in -79.91, 78.18 APE8-rot-na 30.27 APE67-dihe-in -77.76, -4.87 -65.15, -27.78 APE12-dist-na 11.1372 APE11-dist-na 12.7263 APE10-dist-na 10.167 APE9-dist-in 6.81 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.4 0.193 0.251 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4k77 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5HX8A P23458 855 1154 1154.0 66P:1201 Type1 Inactive DFGin 6.449 13.6875 ABAminus -102.8, 8.3 -149.54, 137.76 -131.57, 23.74 295.19, 87.44 -55.43, -25.96 in-in in 7.9251 Saltbr-in 2.7615 HRD-in -74.69, -48.9 64.93, 4.52 in-in-in SNCiii in-in ActLoopNT-in 2.7265 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.85, 104.76 APE9-dihe-in -72.26, 138.18 APE8-dihe-in -80.27, 76.7 APE8-rot-na 26.46 APE67-dihe-in -75.94, -4.44 -51.82, -37.01 APE12-dist-na 11.1195 APE11-dist-na 12.2854 APE10-dist-na 11.3929 APE9-dist-in 6.6113 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.199 0.24 A 302.0 293.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 5hx8 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5HX8B P23458 865 1154 1154.0 66P:1201 Type1 Inactive DFGin 6.4205 13.6309 ABAminus -110.45, 9.62 -150.03, 136.28 -131.01, 24.66 294.53, 92.56 -57.47, -31.3 in-in in 7.7687 Saltbr-in 2.7579 HRD-in -74.49, -50.24 68.18, -1.59 in-in-out SNCiio in-out ActLoopNT-in 2.7739 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -121.57, 40.76 APE9-dihe-in -71.94, 141.78 APE8-dihe-in -79.55, 77.3 APE8-rot-na 24.89 APE67-dihe-in -77.48, 1.58 -49.69, -36.95 APE12-dist-na 10.8376 APE11-dist-na 12.6929 APE10-dist-na 10.8601 APE9-dist-in 6.5503 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.199 0.24 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5hx8 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5WO4A P23458 854 1154 1154.0 B7V:2001 Type1 Inactive DFGin 6.5589 13.4747 ABAminus -113.4, 5.79 -147.65, 137.71 -131.93, 25.73 295.23, 90.95 -54.73, -30.34 in-in in 7.6759 Saltbr-in 2.7544 HRD-in -72.7, -46.52 67.85, -2.92 in-in-out SNCiio in-out ActLoopNT-in 2.8208 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.62, 42.17 APE9-dihe-in -67.76, 140.08 APE8-dihe-in -81.09, 72.14 APE8-rot-na 29.77 APE67-dihe-in -75.22, -1.83 -52.55, -34.79 APE12-dist-na 10.7973 APE11-dist-na 12.9011 APE10-dist-na 10.4662 APE9-dist-in 6.8227 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.84 0.188 0.211 A 302.0 294.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 5wo4 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5WO4B P23458 865 1154 1154.0 B7V:2001 Type1 Inactive DFGin 6.5504 13.4107 ABAminus -111.8, 3.6 -145.5, 139.23 -132.92, 27.81 292.27, 90.98 -57.76, -28.76 in-in in 7.6152 Saltbr-in 2.7806 HRD-in -72.82, -49.06 69.56, 1.39 in-in-out SNCiio in-out ActLoopNT-in 2.8385 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.71, 39.74 APE9-dihe-in -66.32, 138.27 APE8-dihe-in -78.58, 73.11 APE8-rot-na 28.91 APE67-dihe-in -75.88, -0.88 -52.5, -34.22 APE12-dist-na 10.8657 APE11-dist-na 12.9297 APE10-dist-na 10.505 APE9-dist-in 6.7428 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.84 0.188 0.211 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 5wo4 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6HZUA P23458 854 1154 1154.0 GYQ:61201 Type1 Inactive DFGin 6.4583 13.248 ABAminus -115.79, 10.1 -155.61, 143.2 -135.89, 34.69 298.64, 85.33 -68.92, -23.66 in-in in 7.8907 Saltbr-in 2.6049 HRD-in -70.11, -45.53 64.37, 7.1 in-in-out SNCiio in-out ActLoopNT-in 2.7677 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.73, 34.76 APE9-dihe-in -73.48, 139.36 APE8-dihe-in -81.86, 74.79 APE8-rot-na 30.37 APE67-dihe-in -72.43, -9.67 -55.59, -34.31 APE12-dist-na 10.9672 APE11-dist-na 13.1742 APE10-dist-na 9.8871 APE9-dist-in 6.8026 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.204 0.265 A 302.0 293.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6hzu TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6HZUB P23458 865 1154 1154.0 GYQ:61201 Type1 Inactive DFGin 6.4433 13.2473 ABAminus -119.96, 0.48 -155.13, 140.72 -132.65, 33.96 299.27, 84.27 -60.17, -34.27 in-in in 8.0228 Saltbr-in 2.7023 HRD-in -82.42, -47.78 71.93, 4.63 in-in-out SNCiio in-out ActLoopNT-in 2.9233 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.89, 29.59 APE9-dihe-in -63.03, 138.85 APE8-dihe-in -81.19, 78.97 APE8-rot-na 31.69 APE67-dihe-in -73.96, -7.04 -62.12, -30.09 APE12-dist-na 11.006 APE11-dist-na 13.2245 APE10-dist-na 9.8851 APE9-dist-in 6.6567 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.204 0.265 B 302.0 285.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 6hzu TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N77A P23458 866 1154 1154.0 KEJ:1201 Type1 Inactive DFGin 6.3905 13.6543 ABAminus -111.17, 5.93 -155.03, 145.91 -137.7, 32.01 295.16, 86.03 -58.79, -28.87 in-in in 8.2385 Saltbr-in 2.7578 HRD-in -67.03, -46.69 67.69, -1.58 in-in-out SNCiio in-out ActLoopNT-in 2.9237 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 52.82, 53.92 APE9-dihe-in -90.09, 140.83 APE8-dihe-in -78.25, 71.6 APE8-rot-na 26.8 APE67-dihe-in -76.7, -1.13 -52.74, -34.15 APE12-dist-na 11.0789 APE11-dist-na 12.0899 APE10-dist-na 10.9937 APE9-dist-in 7.0193 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.64 0.253 0.282 A 302.0 280.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6n77 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N77B P23458 865 1154 1154.0 KEJ:1202 Type1 Inactive DFGin 6.4472 13.754 ABAminus -112.96, 6.51 -156.54, 142.84 -135.02, 28.22 296.71, 89.38 -58.72, -26.41 in-in in 8.2129 Saltbr-in 2.7371 HRD-in -67.03, -48.62 72.63, -6.63 in-in-out SNCiio in-out ActLoopNT-in 2.8443 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.58, 44.0 APE9-dihe-in -74.12, 131.71 APE8-dihe-in -79.78, 70.31 APE8-rot-na 28.35 APE67-dihe-in -75.35, -3.65 -48.14, -35.74 APE12-dist-na 10.9335 APE11-dist-na 12.6892 APE10-dist-na 9.9871 APE9-dist-in 6.9541 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.64 0.253 0.282 B 302.0 279.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 6n77 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N78A P23458 866 1154 1154.0 KEP:1201 Type1 Inactive DFGin 6.4254 13.5625 ABAminus -105.81, -4.17 -146.0, 143.93 -133.35, 28.47 298.42, 87.41 -54.49, -32.74 in-in in 8.377 Saltbr-in 2.7299 HRD-in -68.76, -52.63 70.44, -3.87 in-in-in SNCiii in-in ActLoopNT-in 2.8114 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.29, 50.22 APE9-dihe-in -86.39, 131.12 APE8-dihe-in -82.28, 79.47 APE8-rot-na 24.58 APE67-dihe-in -76.5, -2.33 -53.51, -34.22 APE12-dist-na 11.515 APE11-dist-na 12.0366 APE10-dist-na 9.0523 APE9-dist-in 6.3769 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.83 0.236 0.261 A 302.0 277.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6n78 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N79A P23458 866 1154 1154.0 KES:1201 Type1 Inactive DFGin 6.4028 13.5254 ABAminus -99.38, -15.25 -133.8, 148.14 -138.23, 25.13 295.77, 92.1 -55.46, -31.57 in-in in 8.2951 Saltbr-in 2.767 HRD-in -74.33, -53.6 68.25, 4.98 in-in-out SNCiio in-out ActLoopNT-in 2.7811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.11, 40.21 APE9-dihe-in -76.58, 124.37 APE8-dihe-in -77.77, 81.63 APE8-rot-na 28.13 APE67-dihe-in -77.42, -2.89 -55.56, -32.1 APE12-dist-na 11.2191 APE11-dist-na 11.8873 APE10-dist-na 9.0753 APE9-dist-in 5.9643 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.27 0.227 0.27 A 302.0 279.0 10 31 29 2 [[583, 847], [875, 1151]] 2.0 6n79 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N7BA P23458 865 1154 1154.0 KEY:1201 Type1 Inactive DFGin 6.4505 13.4556 ABAminus -106.32, -1.48 -152.36, 145.64 -135.47, 28.3 291.96, 86.78 -55.73, -29.48 in-in in 7.7359 Saltbr-in 2.7685 HRD-in -71.34, -49.85 67.55, 5.37 in-in-in SNCiii in-in ActLoopNT-in 2.8058 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.89, 58.14 APE9-dihe-in -96.67, 129.96 APE8-dihe-in -81.34, 78.4 APE8-rot-na 26.42 APE67-dihe-in -77.54, 0.39 -57.77, -29.15 APE12-dist-na 11.0589 APE11-dist-na 11.7277 APE10-dist-na 8.7902 APE9-dist-in 6.3688 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.81 0.222 0.264 A 302.0 280.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7b TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N7CA P23458 865 1154 1154.0 KF1:1201 Type1 Inactive DFGin 6.5135 13.5086 ABAminus -110.36, 6.26 -156.68, 145.17 -136.24, 27.53 295.08, 89.21 -55.95, -29.39 in-in in 8.0959 Saltbr-in 2.7352 HRD-in -68.7, -46.37 70.89, -7.05 in-in-none SNCiin in-none ActLoopNT-in 2.9025 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 95.97 APE9-dihe-in -107.06, 147.5 APE8-dihe-in -79.03, 70.75 APE8-rot-na 27.77 APE67-dihe-in -74.72, -3.56 -53.55, -33.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.4569 APE9-dist-in 7.0847 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.69 0.254 0.288 A 302.0 275.0 15 31 29 2 [[583, 847], [875, 1151]] 2.0 6n7c TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N7CB P23458 865 1154 1154.0 KF1:1202 Type1 Inactive DFGin 6.5102 13.5888 ABAminus -115.1, 6.45 -153.47, 142.93 -133.09, 25.34 294.67, 85.94 -52.61, -29.28 in-in in 8.1554 Saltbr-in 2.7529 HRD-in -67.82, -44.9 68.03, -6.1 in-in-none SNCiin in-none ActLoopNT-in 2.8609 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.81 APE8-dihe-in -80.52, 71.8 APE8-rot-na 28.74 APE67-dihe-in -72.99, -4.02 -55.65, -32.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1147 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.69 0.254 0.288 B 302.0 273.0 17 31 27 4 [[583, 847], [875, 1151]] 2.0 6n7c TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N7DA P23458 865 1154 1154.0 KF4:1201 Type1 Inactive DFGin 6.4763 13.4019 ABAminus -110.67, 4.22 -155.59, 141.48 -134.23, 27.49 295.25, 85.51 -53.77, -30.29 in-in in 8.2846 Saltbr-in 2.6373 HRD-in -73.25, -49.17 70.77, 0.44 in-in-out SNCiio in-out ActLoopNT-in 2.8216 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.59, 31.0 APE9-dihe-in -83.57, 124.64 APE8-dihe-in -81.68, 83.11 APE8-rot-na 27.61 APE67-dihe-in -75.33, -0.8 -58.46, -31.26 APE12-dist-na 11.5609 APE11-dist-na 11.7371 APE10-dist-na 7.5838 APE9-dist-in 5.9758 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.78 0.198 0.234 A 302.0 280.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7d TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSBA P23458 865 1154 1154.0 KGZ:1201 Type1 Inactive DFGin 6.5897 13.5094 ABAminus -116.74, 1.69 -150.38, 137.57 -126.94, 22.04 292.38, 82.89 -70.44, -11.55 in-in in 8.1068 Saltbr-in 2.6145 HRD-in -82.35, -48.96 71.74, 9.14 in-in-out SNCiio in-out ActLoopNT-in 2.8445 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.58, 28.79 APE9-dihe-in -52.22, 132.79 APE8-dihe-in -77.89, 76.1 APE8-rot-na 36.11 APE67-dihe-in -73.96, -4.25 -64.89, -26.96 APE12-dist-na 12.0373 APE11-dist-na 12.29 APE10-dist-na 10.3273 APE9-dist-in 6.8845 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.311 0.354 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsb TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSBB P23458 865 1154 1154.0 KGZ:1201 Type1 Inactive DFGin 6.6473 13.9041 ABAminus -118.58, -5.18 -147.32, 138.8 -128.6, 27.58 293.53, 77.97 -68.36, -16.41 in-in in 8.0489 Saltbr-in 2.7074 HRD-in -76.09, -52.98 75.83, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.9586 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.45, 33.45 APE9-dihe-in -55.89, 141.48 APE8-dihe-in -80.12, 75.54 APE8-rot-na 36.76 APE67-dihe-in -74.19, -3.49 -57.35, -33.46 APE12-dist-na 11.7916 APE11-dist-na 12.9425 APE10-dist-na 10.1411 APE9-dist-in 6.8514 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.311 0.354 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsb TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSCA P23458 865 1154 1154.0 KH5:1201 Type1 Inactive DFGin 6.5538 13.4092 ABAminus -117.31, 8.47 -153.39, 137.28 -129.48, 30.56 297.53, 83.92 -65.76, -23.88 in-in in 7.6629 Saltbr-in 2.6894 HRD-in -79.6, -49.32 70.06, 11.43 in-in-out SNCiio in-out ActLoopNT-in 2.7172 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.9, 27.5 APE9-dihe-in -67.04, 137.63 APE8-dihe-in -80.21, 78.36 APE8-rot-na 37.08 APE67-dihe-in -76.89, -0.21 -62.94, -28.86 APE12-dist-na 11.0035 APE11-dist-na 13.5759 APE10-dist-na 10.2308 APE9-dist-in 6.8584 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.249 0.28 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsc TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSCB P23458 865 1154 1154.0 KH5:1201 Type1 Inactive DFGin 6.5561 13.712 ABAminus -118.51, -2.16 -150.35, 139.43 -132.07, 31.9 298.68, 77.43 -57.63, -28.0 in-in in 7.9025 Saltbr-in 2.662 HRD-in -78.87, -51.69 73.77, 10.39 in-in-out SNCiio in-out ActLoopNT-in 2.9169 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.91, 33.47 APE9-dihe-in -66.35, 135.05 APE8-dihe-in -77.66, 75.63 APE8-rot-na 31.23 APE67-dihe-in -74.4, -5.72 -63.02, -28.16 APE12-dist-na 11.1417 APE11-dist-na 13.5111 APE10-dist-na 10.263 APE9-dist-in 6.9184 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.249 0.28 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsc TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSDA P23458 865 1154 1154.0 KH8:1201 Type1 Inactive DFGin 6.5627 13.2902 ABAminus -121.03, 3.28 -150.09, 139.62 -132.15, 26.01 293.71, 87.42 -59.82, -26.08 in-in in 7.6415 Saltbr-in 2.673 HRD-in -81.56, -47.83 71.88, 7.09 in-in-out SNCiio in-out ActLoopNT-in 2.9247 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.0, 23.61 APE9-dihe-in -58.47, 136.99 APE8-dihe-in -79.35, 76.48 APE8-rot-na 35.13 APE67-dihe-in -77.95, -0.82 -64.48, -27.09 APE12-dist-na 11.0296 APE11-dist-na 13.5683 APE10-dist-na 10.219 APE9-dist-in 6.8056 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.76 0.202 0.238 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsd TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSDB P23458 865 1154 1154.0 KH8:1201 Type1 Inactive DFGin 6.5671 13.4201 ABAminus -123.92, 1.98 -149.52, 139.04 -133.17, 29.94 296.8, 84.79 -64.12, -24.87 in-in in 7.8281 Saltbr-in 2.6195 HRD-in -81.48, -52.31 73.66, 6.38 in-in-out SNCiio in-out ActLoopNT-in 2.8857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 78.39, 5.73 APE9-dihe-in -59.21, 132.36 APE8-dihe-in -78.28, 75.83 APE8-rot-na 31.46 APE67-dihe-in -72.63, -5.35 -64.01, -28.2 APE12-dist-na 11.2098 APE11-dist-na 13.5281 APE10-dist-na 10.362 APE9-dist-in 6.8871 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.76 0.202 0.238 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsd TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSEA P23458 865 1154 1154.0 KHH:1201 Type1 Inactive DFGin 6.5368 13.3482 ABAminus -113.91, 1.27 -156.33, 137.23 -131.71, 27.09 299.32, 82.9 -56.09, -32.48 in-in in 7.8643 Saltbr-in 2.6378 HRD-in -79.69, -48.26 69.1, 11.16 in-in-out SNCiio in-out ActLoopNT-in 2.7164 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -68.92, 43.15 APE9-dihe-in -70.68, 135.44 APE8-dihe-in -74.14, 74.71 APE8-rot-na 28.88 APE67-dihe-in -82.04, -6.18 -60.6, -28.4 APE12-dist-na 9.3275 APE11-dist-na 11.7818 APE10-dist-na 10.4664 APE9-dist-in 6.774 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.265 0.303 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rse TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSEB P23458 865 1154 1154.0 KHH:1201 Type1 Inactive DFGin 6.4607 13.5688 ABAminus -119.02, 6.25 -155.18, 136.02 -130.8, 28.87 296.2, 78.44 -57.74, -31.19 in-in in 8.0339 Saltbr-in 2.5795 HRD-in -78.09, -47.4 66.03, 12.85 in-in-out SNCiio in-out ActLoopNT-in 2.9031 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -77.34, 48.11 APE9-dihe-in -88.98, 140.2 APE8-dihe-in -76.8, 76.65 APE8-rot-na 33.64 APE67-dihe-in -80.09, -3.14 -61.43, -26.93 APE12-dist-na 13.3249 APE11-dist-na 11.8334 APE10-dist-na 10.7555 APE9-dist-in 6.8555 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.265 0.303 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rse TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSHA P23458 865 1154 1154.0 KHE:1201 Type1 Inactive DFGin 6.6345 13.4865 ABAminus -113.16, 6.59 -151.95, 137.99 -130.33, 27.13 294.82, 88.08 -65.9, -20.74 in-in in 7.4405 Saltbr-in 2.5318 HRD-in -77.26, -48.19 64.78, 14.62 in-in-out SNCiio in-out ActLoopNT-in 2.6944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 87.06, 32.22 APE9-dihe-in -74.25, 135.13 APE8-dihe-in -77.78, 76.14 APE8-rot-na 33.2 APE67-dihe-in -80.47, -5.2 -61.66, -26.89 APE12-dist-na 11.1674 APE11-dist-na 12.6391 APE10-dist-na 10.2352 APE9-dist-in 6.904 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.71 0.271 0.311 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsh TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6RSHB P23458 865 1154 1154.0 KHE:1201 Type1 Inactive DFGin 6.627 13.8518 ABAminus -116.98, -3.62 -146.38, 138.52 -131.28, 30.89 293.47, 79.95 -64.48, -19.44 in-in in 7.784 Saltbr-in 2.3752 HRD-in -81.26, -46.13 68.12, 10.14 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 90.62, 16.91 APE9-dihe-in -58.11, 134.31 APE8-dihe-in -78.21, 75.43 APE8-rot-na 34.5 APE67-dihe-in -75.52, -2.49 -58.55, -33.71 APE12-dist-na 11.2189 APE11-dist-na 13.047 APE10-dist-na 10.4487 APE9-dist-in 6.9603 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.71 0.271 0.311 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsh TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6SM8A P23458 854 1154 1154.0 LKT:61201 Type1 Inactive DFGin 6.8129 13.706 ABAminus -101.63, -7.1 -147.81, 142.33 -131.41, 24.39 292.89, 86.49 -54.23, -31.63 in-in in 7.8069 Saltbr-in 2.7315 HRD-in -72.9, -49.47 70.53, 3.61 in-in-out SNCiio in-out ActLoopNT-in 2.8357 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.89, 30.48 APE9-dihe-in -64.02, 138.21 APE8-dihe-in -82.49, 73.83 APE8-rot-na 29.16 APE67-dihe-in -76.27, -2.8 -50.53, -32.36 APE12-dist-na 11.4381 APE11-dist-na 13.2197 APE10-dist-na 10.2463 APE9-dist-in 6.7238 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.213 0.241 A 302.0 296.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 6sm8 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 8S85A P23458 854 1154 1154.0 A1H5R:61201 Type1 Inactive DFGin 6.6301 13.3454 ABAminus -112.23, -7.17 -149.03, 146.72 -132.22, 30.5 297.85, 84.4 -54.75, -31.9 in-in in 7.8523 Saltbr-in 2.6184 HRD-in -76.09, -48.85 71.09, 5.36 in-in-out SNCiio in-out ActLoopNT-in 2.8373 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 58.53, 30.92 APE9-dihe-in -76.65, 137.48 APE8-dihe-in -75.77, 75.79 APE8-rot-na 30.15 APE67-dihe-in -76.06, -7.29 -58.07, -32.61 APE12-dist-na 11.2659 APE11-dist-na 12.6789 APE10-dist-na 10.4668 APE9-dist-in 6.8782 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.75 0.21 0.25 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 8s85 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 8S85B P23458 865 1154 1154.0 A1H5R:61201 Type1 Inactive DFGin 6.6963 13.3555 ABAminus -114.2, -1.94 -152.98, 142.26 -130.74, 31.83 294.81, 85.33 -58.52, -32.2 in-in in 7.7445 Saltbr-in 2.6138 HRD-in -77.39, -48.2 72.5, 8.27 in-in-out SNCiio in-out ActLoopNT-in 2.8906 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.67, 37.06 APE9-dihe-in -66.96, 136.92 APE8-dihe-in -79.85, 74.06 APE8-rot-na 34.04 APE67-dihe-in -73.04, -6.17 -58.28, -33.1 APE12-dist-na 11.159 APE11-dist-na 13.0981 APE10-dist-na 10.4532 APE9-dist-in 6.7965 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.75 0.21 0.25 B 302.0 283.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 8s85 TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N7AA P23458 865 1154 1154.0 KEV:61203 Type1 Inactive DFGin 6.4526 13.3666 ABAminus -116.98, 9.47 -160.4, 147.32 -135.39, 27.13 297.85, 83.25 -58.95, -23.42 in-in in 7.7452 Saltbr-in 2.7564 HRD-in -75.17, -44.67 72.8, -4.01 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.07, 124.84 APE9-dihe-in -104.44, 150.91 APE8-dihe-in -83.53, 72.06 APE8-rot-na 34.1 APE67-dihe-in -76.43, -2.54 -56.05, -29.88 APE12-dist-na 14.6585 APE11-dist-na 9.2784 APE10-dist-na 12.111 APE9-dist-in 7.138 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 A 304.0 278.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6N7AB P23458 854 1154 1154.0 KEV:61202 Type1 Inactive DFGin 6.4703 13.4982 ABAminus -116.23, 10.2 -162.11, 148.53 -137.01, 27.49 296.62, 85.6 -60.22, -22.88 in-in in 7.7761 Saltbr-in 2.7552 HRD-in -73.34, -48.05 70.64, 1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8043 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.78, 65.84 APE9-dihe-in -92.65, 132.46 APE8-dihe-in -84.19, 73.36 APE8-rot-na 33.1 APE67-dihe-in -76.82, -1.21 -55.1, -31.23 APE12-dist-na 10.789 APE11-dist-na 11.6888 APE10-dist-na 9.266 APE9-dist-in 6.8188 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 B 304.0 291.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5KHXA P23458 867 1154 1154.0 6TE:4000 Type1 Inactive DFGin 6.6313 13.5403 ABAminus -113.66, 8.44 -153.85, 134.53 -126.55, 25.21 296.38, 85.41 -59.93, -18.33 in-in in 7.5652 Saltbr-in 2.7784 HRD-in -73.12, -47.99 66.65, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.92, 156.56 APE9-dihe-in -137.25, 140.8 APE8-dihe-in -82.8, 71.88 APE8-rot-na 32.82 APE67-dihe-in -77.93, -4.04 -54.17, -30.94 APE12-dist-na 14.2539 APE11-dist-na 8.4657 APE10-dist-na 10.4355 APE9-dist-in 6.3762 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.4 0.173 0.242 A 316.0 278.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 5khx TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6BBUA P23458 867 1154 1154.0 D7D:4000 Type1 Inactive DFGin 6.4193 13.3 ABAminus -116.63, 12.94 -152.79, 140.28 -132.74, 24.58 296.65, 83.13 -57.55, -25.0 in-in in 7.6445 Saltbr-in 2.7807 HRD-in -73.12, -50.44 71.69, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.8608 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -135.84, 101.53 APE9-dihe-in -119.31, 160.09 APE8-dihe-in -78.32, 76.15 APE8-rot-na 30.95 APE67-dihe-in -74.07, -7.36 -55.8, -32.39 APE12-dist-na 9.7484 APE11-dist-na 11.1833 APE10-dist-na 11.2989 APE9-dist-in 6.2631 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.08 0.185 0.213 A 316.0 281.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6bbu TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6DBNA P23458 867 1154 1154.0 G4J:4000 Type1 Inactive DFGin 6.3393 13.2699 ABAminus -106.28, 2.12 -151.4, 144.25 -137.1, 32.6 295.8, 96.91 -66.86, -18.69 in-in in 7.5962 Saltbr-in 2.792 HRD-in -66.34, -50.63 70.35, -1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8102 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.87, 84.26 APE9-dihe-in -94.42, 151.25 APE8-dihe-in -77.55, 83.04 APE8-rot-na 28.37 APE67-dihe-in -75.2, -10.39 -60.86, -28.98 APE12-dist-na 9.3019 APE11-dist-na 11.0309 APE10-dist-na 10.8091 APE9-dist-in 6.0103 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.48 0.19 0.262 A 316.0 281.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6dbn TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 6W8LA P23458 867 1154 1154.0 R4S:1201 Type1 Inactive DFGin 6.5203 13.6387 ABAminus -117.57, 7.4 -146.11, 138.04 -131.96, 25.84 294.24, 93.82 -58.79, -29.12 in-in in 7.6993 Saltbr-in 2.7472 HRD-in -65.59, -50.27 70.66, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.7962 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.31, 154.48 APE9-dihe-in -145.69, 148.21 APE8-dihe-in -75.35, 73.33 APE8-rot-na 31.68 APE67-dihe-in -71.12, -8.39 -52.84, -34.47 APE12-dist-na 13.7303 APE11-dist-na 8.0423 APE10-dist-na 10.4812 APE9-dist-in 6.4005 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.11 0.197 0.226 A 316.0 280.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6w8l TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5KHWB P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.1878 13.7874 BLAminus -126.62, -174.05 50.66, 92.23 -105.71, 28.99 301.42, 97.18 -62.73, -33.32 in-in in 7.9908 Saltbr-in 2.817 HRD-in -54.38, -55.02 75.74, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -83.14, 18.97 APE9-dihe-in -58.32, 113.18 APE8-dihe-in -82.04, 77.86 APE8-rot-na 28.29 APE67-dihe-in -76.85, -3.42 -56.14, -32.61 APE12-dist-na 7.879 APE11-dist-na 9.6953 APE10-dist-na 6.6047 APE9-dist-in 5.9119 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 B 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 5E1EA P23458 865 1154 1154.0 5JG:1202 Type1 Inactive DFGin 6.6436 13.9325 BLAminus -119.33, -177.28 50.16, 87.79 -101.77, 31.05 290.94, 82.42 -65.82, -24.94 in-in in 7.8719 Saltbr-in 2.7937 HRD-in -75.04, -43.37 64.83, -0.01 in-in-out SNCiio in-out ActLoopNT-in 2.8156 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.99, 41.3 APE9-dihe-in -73.96, 132.79 APE8-dihe-in -79.05, 75.13 APE8-rot-na 22.09 APE67-dihe-in -75.65, -2.64 -52.7, -35.87 APE12-dist-na 10.9808 APE11-dist-na 12.9477 APE10-dist-na 10.1677 APE9-dist-in 6.9083 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 A 290.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1

TYR_JAK1-2 (Tyrosine-protein kinase JAK1)

Total number of chains: 82
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 77 93.9% 6TPFA
DFGin BLAminus 5 6.1% AF-P23458-K2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
JAK1-2 JAK1_HUMAN 6C7YA P23458 869 1153 1154.0 ADP:61201 ATPlike Active DFGin 6.0323 13.967 BLAminus -134.15, -164.18 58.49, 84.96 -109.28, 28.04 298.78, 97.45 -66.39, -27.05 in-in in 8.3107 Saltbr-in 2.7325 HRD-in -67.59, -46.53 68.25, 12.43 in-in-in SNCiii in-in ActLoopNT-in 2.9437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 151.36 APE9-dihe-in -137.76, 143.32 APE8-dihe-in -74.71, 81.76 APE8-rot-na 30.49 APE67-dihe-in -79.4, -2.38 -65.2, -24.66 APE12-dist-na 12.9717 APE11-dist-na 8.0201 APE10-dist-na 10.3436 APE9-dist-in 6.3164 None PTR1035 PTR1035 XRAY 2.499 0.21 0.241 A 286.0 273.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6c7y Homo sapiens TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN AF-P23458-K2A P23458 867 1154 1154.0 No_ligand No_ligand Active DFGin 6.307 13.7726 BLAminus -130.0, -171.31 51.92, 79.2 -91.39, 17.47 288.09, 81.21 -63.19, -25.32 in-in in 8.0857 Saltbr-in 2.7191 HRD-in -67.76, -41.14 64.22, -10.98 in-in-in SNCiii in-in ActLoopNT-in 2.9399 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -50.83, 123.48 APE9-dihe-in -125.8, 136.55 APE8-dihe-in -75.77, 67.19 APE8-rot-na 34.45 APE67-dihe-in -77.12, -11.68 -54.83, -26.9 APE12-dist-na 13.9103 APE11-dist-na 8.5318 APE10-dist-na 10.6595 APE9-dist-in 7.0627 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 31 31 0 [[583, 847], [875, 1151]] 2.0 AF-P23458-K2 Homo sapiens TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN AF-P23458-K4A P23458 867 1154 1154.0 No_ligand No_ligand Active DFGin 6.0337 13.5522 BLAminus -127.94, -176.44 52.21, 91.21 -99.55, 15.91 293.58, 76.0 -63.9, -24.71 in-in in 7.8098 Saltbr-in 2.7151 HRD-in -69.66, -43.24 62.91, -1.77 in-in-in SNCiii in-in ActLoopNT-in 2.9198 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -47.59, 114.14 APE9-dihe-in -120.02, 146.94 APE8-dihe-in -73.57, 63.93 APE8-rot-na 37.51 APE67-dihe-in -76.35, -14.96 -54.26, -27.82 APE12-dist-na 13.6974 APE11-dist-na 8.1142 APE10-dist-na 10.9163 APE9-dist-in 6.7347 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 31 31 0 [[583, 847], [875, 1151]] 2.0 AF-P23458-K4 Homo sapiens TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5KHWA P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.2929 13.5952 ABAminus -113.62, -36.19 -113.51, 112.49 -104.48, 28.51 302.05, 98.46 -68.45, -35.55 in-in in 8.0172 Saltbr-in 2.8107 HRD-in -53.69, -54.55 74.32, 4.71 in-in-in SNCiii in-in ActLoopNT-in 2.8167 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.25, 151.86 APE9-dihe-in -139.19, 145.92 APE8-dihe-in -78.07, 75.73 APE8-rot-na 29.65 APE67-dihe-in -77.72, -3.4 -55.44, -31.5 APE12-dist-na 13.0141 APE11-dist-na 7.3323 APE10-dist-na 9.9045 APE9-dist-in 6.0223 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 A 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E4LE P23458 864 1154 1154.0 No_ligand No_ligand Inactive DFGin 6.4627 13.613 ABAminus -114.05, 7.25 -155.92, 142.83 -135.92, 30.26 296.52, 85.61 -59.94, -28.28 in-in in 7.8702 Saltbr-in 2.6251 HRD-in -76.43, -49.33 70.91, 5.03 in-in-out SNCiio in-out ActLoopNT-in 2.809 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.8, 27.83 APE9-dihe-in -58.48, 132.7 APE8-dihe-in -75.95, 78.2 APE8-rot-na 25.62 APE67-dihe-in -75.39, -5.67 -60.62, -30.34 APE12-dist-na 11.4043 APE11-dist-na 12.8654 APE10-dist-na 10.3351 APE9-dist-in 6.7659 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 E 302.0 282.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 3EYGA P23458 865 1154 1154.0 MI1:1 Type1 Inactive DFGin 6.4845 13.5855 ABAminus -124.32, 8.36 -155.42, 148.92 -141.71, 28.09 295.61, 92.98 -69.61, -22.8 in-in in 7.7723 Saltbr-in 2.8707 HRD-in -73.25, -48.81 76.52, 2.4 in-in-out SNCiio in-out ActLoopNT-in 2.829 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -99.1, 4.52 APE9-dihe-in -69.5, 129.84 APE8-dihe-in -77.86, 81.49 APE8-rot-na 30.22 APE67-dihe-in -79.56, -5.41 -59.51, -27.49 APE12-dist-na 10.7554 APE11-dist-na 11.0552 APE10-dist-na 6.7069 APE9-dist-in 5.5949 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.171 0.214 A 290.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 3eyg Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 3EYHA P23458 865 1154 1154.0 IZA:2001 Type1 Inactive DFGin 6.7108 13.7777 ABAminus -123.79, 5.59 -151.26, 147.61 -137.78, 30.19 296.78, 89.6 -63.64, -28.15 in-in in 7.7407 Saltbr-in 2.8801 HRD-in -74.82, -42.99 68.23, 5.73 in-in-in SNCiii in-in ActLoopNT-in 2.799 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -136.22, 60.46 APE9-dihe-in -76.43, 138.22 APE8-dihe-in -79.32, 79.81 APE8-rot-na 29.32 APE67-dihe-in -73.68, -7.92 -57.92, -30.28 APE12-dist-na 10.347 APE11-dist-na 10.9945 APE10-dist-na 9.0512 APE9-dist-in 5.5722 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.178 0.237 A 290.0 287.0 3 31 31 0 [[583, 847], [875, 1151]] 2.0 3eyh Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5E1EB P23458 865 1154 1154.0 5JG:1201 Type1 Inactive DFGin 6.6155 13.7027 ABAminus -133.31, 28.19 -149.71, 114.81 -114.53, 26.1 291.32, 84.42 -63.72, -24.05 in-in in 7.7649 Saltbr-in 2.7841 HRD-in -74.91, -42.75 64.28, 0.85 in-in-out SNCiio in-out ActLoopNT-in 2.8012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.64, 38.4 APE9-dihe-in -74.25, 132.21 APE8-dihe-in -79.08, 75.2 APE8-rot-na 22.34 APE67-dihe-in -75.56, -2.49 -52.66, -36.06 APE12-dist-na 10.8574 APE11-dist-na 13.3108 APE10-dist-na 10.0385 APE9-dist-in 6.8736 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 B 290.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6AAHA P23458 865 1154 1154.0 9T6:1201 Type1 Inactive DFGin 6.3189 13.4568 ABAminus -111.86, -1.07 -147.59, 142.74 -130.77, 31.7 296.21, 81.89 -59.29, -31.87 in-in in 7.8369 Saltbr-in 2.7851 HRD-in -79.04, -51.9 74.79, 8.24 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.78, 24.87 APE9-dihe-in -65.36, 146.43 APE8-dihe-in -84.69, 80.23 APE8-rot-na 32.65 APE67-dihe-in -73.6, -4.54 -60.24, -33.63 APE12-dist-na 10.5006 APE11-dist-na 13.0658 APE10-dist-na 9.9007 APE9-dist-in 6.4221 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.83 0.225 0.255 A 290.0 285.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 6aah Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6AAHB P23458 865 1154 1154.0 9T6:1201 Type1 Inactive DFGin 6.4616 13.5876 ABAminus -114.68, 9.66 -151.81, 133.96 -131.35, 23.59 291.95, 87.28 -61.54, -23.21 in-in in 8.0413 Saltbr-in 2.6139 HRD-in -74.7, -48.84 74.08, 5.49 in-in-in SNCiii in-in ActLoopNT-in 2.7826 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.14, 67.65 APE9-dihe-in -109.05, 132.69 APE8-dihe-in -79.19, 76.3 APE8-rot-na 35.14 APE67-dihe-in -76.24, -3.1 -57.7, -33.14 APE12-dist-na 10.1909 APE11-dist-na 12.4612 APE10-dist-na 9.1413 APE9-dist-in 6.5428 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.83 0.225 0.255 B 290.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6aah Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6TPEA P23458 864 1153 1154.0 NTW:1201 Type1 Inactive DFGin 6.4521 13.4517 ABAminus -113.52, 27.97 -159.85, 137.75 -139.89, 37.69 300.95, 90.85 -70.73, -32.53 in-in in 7.9845 Saltbr-in 2.8979 HRD-in -77.39, -48.43 67.11, 20.0 in-in-in SNCiii in-in ActLoopNT-in 2.7214 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.39, 82.51 APE9-dihe-in -109.84, 138.7 APE8-dihe-in -71.54, 85.2 APE8-rot-na 346.93 APE67-dihe-in -79.64, -10.25 -64.68, -30.27 APE12-dist-na 10.1252 APE11-dist-na 12.1296 APE10-dist-na 10.4977 APE9-dist-in 6.4525 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.87 0.249 0.298 A 291.0 283.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpe Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6TPEB P23458 864 1154 1154.0 NTW:1201 Type1 Inactive DFGin 6.4487 13.4616 ABAminus -113.4, 27.83 -159.97, 137.64 -139.8, 37.79 300.87, 90.88 -70.61, -32.51 in-in in 7.9939 Saltbr-in 2.8934 HRD-in -77.28, -48.49 67.12, 19.91 in-in-in SNCiii in-in ActLoopNT-in 2.7232 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.48, 82.82 APE9-dihe-in -109.8, 138.58 APE8-dihe-in -71.3, 85.03 APE8-rot-na 346.96 APE67-dihe-in -79.6, -10.33 -64.53, -30.29 APE12-dist-na 10.1332 APE11-dist-na 12.1297 APE10-dist-na 10.5127 APE9-dist-in 6.4531 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.87 0.249 0.298 B 291.0 283.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpe Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6TPFA P23458 864 1153 1154.0 NTQ:1201 Type1 Inactive DFGin 6.5489 13.5659 ABAminus -112.13, 4.42 -147.17, 134.74 -132.51, 36.57 297.52, 87.9 -61.56, -38.59 in-in in 7.9072 Saltbr-in 2.7233 HRD-in -81.26, -43.5 66.58, 8.45 in-in-out SNCiio in-out ActLoopNT-in 2.7552 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.97, 47.61 APE9-dihe-in -75.75, 153.17 APE8-dihe-in -82.59, 85.83 APE8-rot-na 32.54 APE67-dihe-in -74.51, -8.6 -66.85, -35.11 APE12-dist-na 10.9508 APE11-dist-na 12.7019 APE10-dist-na 10.9448 APE9-dist-in 6.7022 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.31 0.266 0.327 A 291.0 288.0 2 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpf Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6TPFB P23458 865 1153 1154.0 NTQ:1201 Type1 Inactive DFGin 6.5159 13.6075 ABAminus -112.38, 6.69 -146.72, 134.6 -130.81, 35.94 297.58, 85.61 -65.62, -37.25 in-in in 7.8432 Saltbr-in 2.7199 HRD-in -83.36, -42.45 66.49, 9.9 in-in-out SNCiio in-out ActLoopNT-in 2.7624 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 46.13, 45.8 APE9-dihe-in -71.68, 152.43 APE8-dihe-in -82.66, 85.94 APE8-rot-na 32.5 APE67-dihe-in -74.85, -9.43 -66.05, -35.76 APE12-dist-na 10.9678 APE11-dist-na 12.3423 APE10-dist-na 11.4191 APE9-dist-in 6.666 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.31 0.266 0.327 B 291.0 278.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 6tpf Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6GGHA P23458 865 1154 1154.0 EYQ:1201 Type1 Inactive DFGin 6.4736 13.7082 ABAminus -120.02, -5.29 -148.47, 136.5 -125.28, 25.35 294.61, 85.16 -56.12, -34.28 in-in in 7.7182 Saltbr-in 2.5913 HRD-in -74.74, -47.68 65.51, 13.25 in-in-out SNCiio in-out ActLoopNT-in 2.7664 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 52.1, 57.9 APE9-dihe-in -80.13, 145.81 APE8-dihe-in -79.99, 78.75 APE8-rot-na 31.21 APE67-dihe-in -74.16, -4.73 -59.55, -32.45 APE12-dist-na 10.1051 APE11-dist-na 9.8842 APE10-dist-na 9.9812 APE9-dist-in 6.1057 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.7 0.192 0.262 A 292.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6ggh Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6GGHB P23458 863 1154 1154.0 EYQ:1201 Type1 Inactive DFGin 6.3928 13.8854 ABAminus -111.86, -4.02 -150.16, 140.27 -128.87, 25.84 291.88, 86.63 -62.88, -36.22 in-in in 7.7947 Saltbr-in 2.5918 HRD-in -72.53, -48.04 68.9, 11.02 in-in-out SNCiio in-out ActLoopNT-in 2.7893 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 72.16, 30.7 APE9-dihe-in -88.91, 131.65 APE8-dihe-in -78.72, 80.52 APE8-rot-na 31.53 APE67-dihe-in -73.31, -5.76 -61.33, -30.45 APE12-dist-na 10.2866 APE11-dist-na 10.6521 APE10-dist-na 8.3392 APE9-dist-in 5.9942 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.7 0.192 0.262 B 292.0 282.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6ggh Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.8 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6ELRA P23458 854 1154 1154.0 BFK:1201 Type1 Inactive DFGin 6.5967 13.5994 ABAminus -108.66, 4.92 -152.97, 140.13 -131.61, 26.62 294.97, 83.84 -57.45, -30.06 in-in in 7.7786 Saltbr-in 2.7415 HRD-in -71.99, -47.83 69.61, 1.99 in-in-out SNCiio in-out ActLoopNT-in 2.831 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.35, 32.0 APE9-dihe-in -64.21, 131.29 APE8-dihe-in -79.64, 72.85 APE8-rot-na 28.8 APE67-dihe-in -76.69, -6.06 -50.77, -33.65 APE12-dist-na 10.934 APE11-dist-na 12.9294 APE10-dist-na 9.9193 APE9-dist-in 6.8377 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.182 0.205 A 301.0 289.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6elr Homo sapiens TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6ELRB P23458 865 1154 1154.0 BFK:1201 Type1 Inactive DFGin 6.6014 13.5309 ABAminus -109.26, 5.99 -154.04, 139.83 -131.25, 27.64 294.03, 83.78 -58.7, -28.76 in-in in 7.7388 Saltbr-in 2.7522 HRD-in -72.31, -47.94 70.47, 1.78 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.07, 32.45 APE9-dihe-in -65.92, 131.99 APE8-dihe-in -78.37, 73.16 APE8-rot-na 28.72 APE67-dihe-in -77.26, -5.72 -51.85, -33.17 APE12-dist-na 11.0567 APE11-dist-na 13.1477 APE10-dist-na 10.0689 APE9-dist-in 6.8534 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.182 0.205 B 301.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6elr Homo sapiens TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6SM8B P23458 865 1154 1154.0 LKT:61201 Type1 Inactive DFGin 6.8061 13.6678 ABAminus -102.82, -5.52 -148.54, 142.3 -131.39, 24.74 291.91, 87.01 -56.81, -29.39 in-in in 7.8014 Saltbr-in 2.7112 HRD-in -72.52, -51.3 71.87, 8.95 in-in-out SNCiio in-out ActLoopNT-in 2.8319 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.32, 29.21 APE9-dihe-in -64.29, 137.39 APE8-dihe-in -82.59, 73.84 APE8-rot-na 28.56 APE67-dihe-in -76.5, -2.32 -51.19, -31.92 APE12-dist-na 11.5209 APE11-dist-na 13.3431 APE10-dist-na 10.3287 APE9-dist-in 6.6704 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.213 0.241 B 301.0 284.0 6 31 29 2 [[583, 847], [875, 1151]] 2.0 6sm8 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6SMBA P23458 863 1153 1154.0 LKQ:1201 Type1 Inactive DFGin 6.6066 13.7308 ABAminus -104.09, 12.38 -161.47, 134.46 -125.84, 26.47 298.3, 80.99 -58.62, -24.17 in-in in 7.8314 Saltbr-in 2.6426 HRD-in -73.47, -45.53 65.45, 5.36 in-in-out SNCiio in-out ActLoopNT-in 2.7488 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.53, 41.14 APE9-dihe-in -70.01, 131.09 APE8-dihe-in -75.02, 72.06 APE8-rot-na 25.33 APE67-dihe-in -73.28, -2.79 -51.04, -36.86 APE12-dist-na 12.0201 APE11-dist-na 12.7163 APE10-dist-na 10.2351 APE9-dist-in 6.7545 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.04 0.224 0.265 A 301.0 288.0 3 31 31 0 [[583, 847], [875, 1151]] 2.0 6smb Homo sapiens TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6SMBB P23458 863 1153 1154.0 LKQ:1201 Type1 Inactive DFGin 6.6183 13.8112 ABAminus -106.29, 15.46 -163.61, 135.62 -126.74, 26.38 298.65, 81.43 -58.83, -23.63 in-in in 7.8691 Saltbr-in 2.6267 HRD-in -72.91, -46.19 66.2, 3.06 in-in-out SNCiio in-out ActLoopNT-in 2.7449 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 76.78, 22.71 APE9-dihe-in -68.31, 133.01 APE8-dihe-in -75.13, 72.89 APE8-rot-na 25.36 APE67-dihe-in -72.9, -3.33 -50.86, -36.85 APE12-dist-na 10.8308 APE11-dist-na 12.5749 APE10-dist-na 10.4555 APE9-dist-in 6.6799 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.04 0.224 0.265 B 301.0 282.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6smb Homo sapiens TYR_JAK1-2_HUMAN TYR 2.1e-87 298.7 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E4LA P23458 865 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5059 13.5932 ABAminus -113.26, 1.55 -155.7, 141.31 -133.96, 30.85 296.7, 84.55 -61.93, -29.15 in-in in 7.7283 Saltbr-in 2.3665 HRD-in -82.62, -51.73 77.35, 2.42 in-in-out SNCiio in-out ActLoopNT-in 2.8326 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.62, 29.91 APE9-dihe-in -55.83, 134.62 APE8-dihe-in -77.55, 77.11 APE8-rot-na 23.92 APE67-dihe-in -76.85, -4.17 -58.31, -32.93 APE12-dist-na 11.099 APE11-dist-na 12.7606 APE10-dist-na 10.3479 APE9-dist-in 6.603 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 A 302.0 279.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E4LB P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.4683 13.6897 ABAminus -115.34, 5.94 -154.23, 143.98 -136.31, 29.8 294.89, 85.73 -63.4, -28.12 in-in in 7.872 Saltbr-in 2.6248 HRD-in -80.23, -45.9 70.61, 1.75 in-in-out SNCiio in-out ActLoopNT-in 2.7501 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.56, 32.84 APE9-dihe-in -59.39, 139.65 APE8-dihe-in -81.36, 75.53 APE8-rot-na 28.93 APE67-dihe-in -77.55, -4.05 -62.31, -27.51 APE12-dist-na 10.9946 APE11-dist-na 12.667 APE10-dist-na 10.0695 APE9-dist-in 6.6324 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 B 302.0 281.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E4LD P23458 864 1154 1154.0 0NH:1201 Type1 Inactive DFGin 6.5361 13.748 ABAminus -114.27, -0.81 -153.61, 143.22 -135.12, 28.03 293.73, 85.38 -57.66, -27.04 in-in in 7.7412 Saltbr-in 2.5547 HRD-in -77.01, -53.08 75.86, 4.71 in-in-out SNCiio in-out ActLoopNT-in 2.8229 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -115.68, 33.68 APE9-dihe-in -65.48, 130.64 APE8-dihe-in -74.63, 79.76 APE8-rot-na 26.43 APE67-dihe-in -75.57, -2.67 -62.18, -32.34 APE12-dist-na 11.5127 APE11-dist-na 12.875 APE10-dist-na 10.4155 APE9-dist-in 6.7005 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.0 0.19 0.228 D 302.0 283.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E4NA P23458 854 1154 1154.0 0NL:61201 Type1 Inactive DFGin 6.3841 13.5599 ABAminus -120.02, 11.21 -158.48, 139.99 -136.43, 26.78 297.09, 85.57 -63.39, -21.4 in-in in 7.7905 Saltbr-in 2.5546 HRD-in -80.31, -49.85 72.5, 4.9 in-in-out SNCiio in-out ActLoopNT-in 2.8478 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.76, 48.8 APE9-dihe-in -75.99, 139.57 APE8-dihe-in -78.93, 73.17 APE8-rot-na 33.7 APE67-dihe-in -74.47, -3.41 -60.94, -30.72 APE12-dist-na 11.0707 APE11-dist-na 12.7564 APE10-dist-na 10.411 APE9-dist-in 6.8318 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.226 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4n Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E4NB P23458 865 1154 1154.0 0NL:61201 Type1 Inactive DFGin 6.3464 13.5023 ABAminus -119.9, 9.63 -155.68, 139.61 -133.8, 28.11 297.19, 80.43 -62.66, -24.74 in-in in 7.7373 Saltbr-in 2.6034 HRD-in -78.32, -48.47 74.25, 0.38 in-in-out SNCiio in-out ActLoopNT-in 2.8745 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.54, 49.17 APE9-dihe-in -76.21, 142.06 APE8-dihe-in -79.22, 71.62 APE8-rot-na 25.59 APE67-dihe-in -77.0, -5.97 -60.76, -27.4 APE12-dist-na 11.1624 APE11-dist-na 12.7927 APE10-dist-na 10.4333 APE9-dist-in 6.9387 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.226 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e4n Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E5WA P23458 854 1154 1154.0 0NT:61201 Type1 Inactive DFGin 6.562 13.397 ABAminus -118.14, 5.18 -153.89, 137.32 -129.51, 26.76 295.21, 88.69 -58.94, -26.21 in-in in 7.7041 Saltbr-in 2.6868 HRD-in -73.36, -50.75 70.96, 2.6 in-in-out SNCiio in-out ActLoopNT-in 2.8337 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.84, 26.34 APE9-dihe-in -57.31, 135.68 APE8-dihe-in -78.98, 72.49 APE8-rot-na 27.03 APE67-dihe-in -72.09, -3.1 -47.71, -39.24 APE12-dist-na 11.0884 APE11-dist-na 13.5699 APE10-dist-na 10.4497 APE9-dist-in 6.7378 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.86 0.184 0.21 A 302.0 293.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4e5w Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4E5WB P23458 865 1153 1154.0 0NT:61202 Type1 Inactive DFGin 6.5301 13.3501 ABAminus -114.8, 7.46 -153.87, 137.96 -129.8, 26.64 296.41, 93.24 -58.91, -27.51 in-in in 7.6911 Saltbr-in 2.6865 HRD-in -74.04, -50.94 71.65, 3.46 in-in-out SNCiio in-out ActLoopNT-in 2.8325 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.41, 26.14 APE9-dihe-in -57.59, 134.48 APE8-dihe-in -78.71, 72.64 APE8-rot-na 26.79 APE67-dihe-in -72.94, -2.19 -48.23, -38.49 APE12-dist-na 11.1134 APE11-dist-na 13.5566 APE10-dist-na 10.4312 APE9-dist-in 6.7576 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.86 0.184 0.21 B 302.0 280.0 9 31 29 2 [[583, 847], [875, 1151]] 2.0 4e5w Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4EHZA P23458 858 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.2945 13.63 ABAminus -122.46, 12.74 -158.91, 149.59 -139.33, 23.83 295.89, 89.08 -61.4, -20.25 in-in in 7.7955 Saltbr-in 2.9362 HRD-in -79.41, -51.26 80.05, -0.3 in-in-out SNCiio in-out ActLoopNT-in 2.8662 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.49, 24.25 APE9-dihe-in -61.79, 133.39 APE8-dihe-in -76.86, 73.91 APE8-rot-na 30.52 APE67-dihe-in -75.94, -6.94 -60.76, -27.83 APE12-dist-na 11.4383 APE11-dist-na 13.1596 APE10-dist-na 9.8707 APE9-dist-in 7.0319 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 A 302.0 292.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4EHZB P23458 865 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.3175 13.7298 ABAminus -116.35, 3.51 -150.61, 148.16 -138.87, 32.34 292.95, 86.02 -67.41, -23.21 in-in in 7.8685 Saltbr-in 2.7634 HRD-in -83.57, -44.01 70.15, -1.08 in-in-out SNCiio in-out ActLoopNT-in 2.7334 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.9, 29.19 APE9-dihe-in -67.89, 136.88 APE8-dihe-in -75.68, 68.81 APE8-rot-na 33.04 APE67-dihe-in -71.9, -6.58 -49.99, -36.99 APE12-dist-na 11.4195 APE11-dist-na 13.393 APE10-dist-na 10.1247 APE9-dist-in 6.9909 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4EHZC P23458 866 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.3172 13.6208 ABAminus -118.15, 8.14 -148.22, 154.09 -141.74, 25.14 292.74, 84.54 -60.05, -18.24 in-in in 7.8585 Saltbr-in 2.8403 HRD-in -77.85, -48.09 78.3, 3.1 in-in-out SNCiio in-out ActLoopNT-in 2.7238 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -117.81, 30.11 APE9-dihe-in -57.01, 145.43 APE8-dihe-in -85.32, 74.95 APE8-rot-na 31.15 APE67-dihe-in -74.27, -3.28 -56.74, -31.49 APE12-dist-na 10.9751 APE11-dist-na 13.0044 APE10-dist-na 10.1803 APE9-dist-in 6.676 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 C 302.0 280.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4EHZD P23458 865 1154 1154.0 JAK:1201 Type1 Inactive DFGin 6.4285 13.533 ABAminus -123.86, 16.47 -158.34, 146.22 -137.38, 32.15 296.06, 77.8 -67.83, -20.15 in-in in 7.6786 Saltbr-in 2.9996 HRD-in -85.88, -43.73 70.18, 7.9 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.38, 26.48 APE9-dihe-in -59.77, 138.32 APE8-dihe-in -81.72, 74.58 APE8-rot-na 32.67 APE67-dihe-in -77.67, -4.82 -52.47, -31.56 APE12-dist-na 11.0435 APE11-dist-na 12.9621 APE10-dist-na 10.0088 APE9-dist-in 6.6881 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.174 0.174 0.229 D 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ehz Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4EI4A P23458 854 1154 1154.0 0Q2:61201 Type1 Inactive DFGin 6.3615 13.4524 ABAminus -125.08, 21.55 -162.93, 136.7 -132.47, 29.54 298.16, 82.51 -65.62, -22.07 in-in in 7.843 Saltbr-in 2.6125 HRD-in -82.16, -48.37 72.58, 5.29 in-in-out SNCiio in-out ActLoopNT-in 2.7441 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.53, 42.94 APE9-dihe-in -71.49, 136.49 APE8-dihe-in -77.62, 74.63 APE8-rot-na 31.88 APE67-dihe-in -76.69, -5.39 -62.91, -28.92 APE12-dist-na 10.9829 APE11-dist-na 12.7533 APE10-dist-na 10.2586 APE9-dist-in 6.7838 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.22 0.202 0.239 A 302.0 290.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 4ei4 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4EI4B P23458 865 1154 1154.0 0Q2:61201 Type1 Inactive DFGin 6.3821 13.5185 ABAminus -120.19, 16.13 -160.02, 140.78 -136.52, 31.88 292.39, 84.5 -65.63, -28.61 in-in in 7.8532 Saltbr-in 2.8267 HRD-in -84.06, -46.22 68.02, 6.16 in-in-out SNCiio in-out ActLoopNT-in 2.7517 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.4, 38.28 APE9-dihe-in -67.47, 135.5 APE8-dihe-in -75.19, 75.25 APE8-rot-na 28.78 APE67-dihe-in -75.9, -4.89 -57.78, -34.83 APE12-dist-na 11.0547 APE11-dist-na 12.6874 APE10-dist-na 10.2359 APE9-dist-in 6.7889 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.22 0.202 0.239 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ei4 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4FK6A P23458 863 1154 1154.0 0UJ:1201 Type1 Inactive DFGin 6.5774 13.4134 ABAminus -112.19, 2.74 -147.97, 135.94 -128.79, 22.38 293.74, 90.76 -52.95, -29.36 in-in in 7.654 Saltbr-in 2.6738 HRD-in -73.71, -49.95 70.6, -2.02 in-in-out SNCiio in-out ActLoopNT-in 2.8101 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.7, 28.56 APE9-dihe-in -63.18, 134.95 APE8-dihe-in -78.74, 77.08 APE8-rot-na 27.11 APE67-dihe-in -76.1, -2.34 -51.26, -33.75 APE12-dist-na 11.3197 APE11-dist-na 12.8559 APE10-dist-na 10.101 APE9-dist-in 6.6455 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.211 0.251 A 302.0 287.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 4fk6 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4FK6B P23458 864 1154 1154.0 0UJ:1201 Type1 Inactive DFGin 6.5944 13.4059 ABAminus -112.12, 2.82 -147.85, 135.79 -128.94, 22.08 293.63, 90.77 -52.49, -30.06 in-in in 7.6382 Saltbr-in 2.6795 HRD-in -73.35, -50.23 70.8, -1.92 in-in-out SNCiio in-out ActLoopNT-in 2.8173 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.94, 28.16 APE9-dihe-in -62.61, 135.05 APE8-dihe-in -78.72, 77.07 APE8-rot-na 27.01 APE67-dihe-in -76.01, -2.17 -51.54, -33.82 APE12-dist-na 11.3135 APE11-dist-na 12.766 APE10-dist-na 10.1407 APE9-dist-in 6.6468 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.211 0.251 B 302.0 286.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 4fk6 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4I5CA P23458 865 1154 1154.0 C5I:61201 Type1 Inactive DFGin 6.372 13.0985 ABAminus -114.74, 13.12 -159.95, 138.51 -132.46, 27.57 300.19, 86.09 -57.95, -29.46 in-in in 7.6484 Saltbr-in 2.6628 HRD-in -72.51, -44.79 66.5, 0.54 in-in-out SNCiio in-out ActLoopNT-in 2.903 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -124.02, 33.91 APE9-dihe-in -66.46, 131.24 APE8-dihe-in -75.55, 75.28 APE8-rot-na 31.15 APE67-dihe-in -75.41, -9.49 -50.0, -34.68 APE12-dist-na 11.2602 APE11-dist-na 13.3407 APE10-dist-na 10.1945 APE9-dist-in 6.774 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.1 0.193 0.245 A 302.0 281.0 9 31 30 1 [[583, 847], [875, 1151]] 2.0 4i5c Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4I5CB P23458 854 1154 1154.0 C5I:61205 Type1 Inactive DFGin 6.2884 13.0623 ABAminus -117.66, 20.22 -158.68, 137.22 -131.37, 22.03 299.16, 87.56 -52.78, -31.38 in-in in 7.784 Saltbr-in 2.5861 HRD-in -74.37, -52.31 71.43, 0.95 in-in-out SNCiio in-out ActLoopNT-in 2.9476 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.41, 21.23 APE9-dihe-in -58.7, 133.33 APE8-dihe-in -78.45, 70.87 APE8-rot-na 28.87 APE67-dihe-in -73.75, -3.17 -47.7, -37.18 APE12-dist-na 11.1462 APE11-dist-na 13.1938 APE10-dist-na 10.0316 APE9-dist-in 6.8402 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.1 0.193 0.245 B 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4i5c Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4IVBA P23458 854 1154 1154.0 1J5:61201 Type1 Inactive DFGin 6.4461 13.3982 ABAminus -120.37, 8.79 -154.43, 145.03 -134.59, 25.95 296.41, 85.72 -59.41, -26.27 in-in in 7.7771 Saltbr-in 2.6073 HRD-in -81.27, -49.76 73.46, 5.83 in-in-out SNCiio in-out ActLoopNT-in 2.9009 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.65, 36.69 APE9-dihe-in -67.09, 139.5 APE8-dihe-in -78.95, 74.88 APE8-rot-na 31.26 APE67-dihe-in -75.42, -5.51 -58.71, -32.55 APE12-dist-na 11.2148 APE11-dist-na 12.9349 APE10-dist-na 10.3112 APE9-dist-in 6.7806 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.221 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivb Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4IVBB P23458 865 1154 1154.0 1J5:61201 Type1 Inactive DFGin 6.4294 13.4146 ABAminus -116.62, 7.74 -154.57, 143.33 -132.65, 26.65 294.75, 85.72 -57.0, -32.17 in-in in 7.7125 Saltbr-in 2.6507 HRD-in -82.29, -46.68 69.34, 6.53 in-in-out SNCiio in-out ActLoopNT-in 2.8948 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.2, 32.35 APE9-dihe-in -63.44, 138.0 APE8-dihe-in -78.25, 77.26 APE8-rot-na 32.13 APE67-dihe-in -75.77, -2.93 -62.98, -29.79 APE12-dist-na 11.2627 APE11-dist-na 12.9835 APE10-dist-na 10.306 APE9-dist-in 6.7691 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.9 0.183 0.221 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivb Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4IVCA P23458 854 1154 1154.0 1J6:61201 Type1 Inactive DFGin 6.2486 13.2512 ABAminus -114.51, 9.81 -157.21, 145.73 -138.3, 37.36 304.45, 81.48 -64.22, -30.51 in-in in 7.8262 Saltbr-in 2.6917 HRD-in -91.76, -42.16 67.22, -0.09 in-in-out SNCiio in-out ActLoopNT-in 2.8419 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.76, 45.97 APE9-dihe-in -72.9, 142.32 APE8-dihe-in -77.97, 76.61 APE8-rot-na 30.79 APE67-dihe-in -73.52, -3.32 -54.87, -39.45 APE12-dist-na 11.1918 APE11-dist-na 12.6517 APE10-dist-na 10.1709 APE9-dist-in 6.5489 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.35 0.2 0.263 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivc Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4IVCB P23458 865 1154 1154.0 1J6:61201 Type1 Inactive DFGin 6.3131 13.3466 ABAminus -119.67, 6.43 -149.04, 145.44 -134.49, 29.55 297.17, 82.22 -60.5, -32.79 in-in in 7.5246 Saltbr-in 2.2767 HRD-in -89.31, -45.09 71.21, 3.65 in-in-out SNCiio in-out ActLoopNT-in 2.7171 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -101.71, 20.54 APE9-dihe-in -65.21, 135.06 APE8-dihe-in -79.05, 83.59 APE8-rot-na 28.99 APE67-dihe-in -78.13, -7.38 -62.67, -27.87 APE12-dist-na 11.123 APE11-dist-na 12.804 APE10-dist-na 9.574 APE9-dist-in 6.6074 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.35 0.2 0.263 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivc Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4IVDA P23458 854 1154 1154.0 15T:61201 Type1 Inactive DFGin 6.3094 13.3038 ABAminus -118.43, 8.35 -154.11, 148.17 -137.65, 24.48 298.46, 83.68 -55.12, -27.34 in-in in 7.7486 Saltbr-in 2.7286 HRD-in -85.26, -46.42 71.64, 5.83 in-in-out SNCiio in-out ActLoopNT-in 2.9031 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -118.71, 33.92 APE9-dihe-in -63.4, 140.18 APE8-dihe-in -80.26, 75.71 APE8-rot-na 32.55 APE67-dihe-in -74.69, -4.74 -58.39, -31.37 APE12-dist-na 11.2468 APE11-dist-na 12.9702 APE10-dist-na 10.2675 APE9-dist-in 6.6549 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.93 0.204 0.247 A 302.0 291.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivd Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4IVDB P23458 865 1154 1154.0 15T:61201 Type1 Inactive DFGin 6.4106 13.3698 ABAminus -112.55, 2.72 -159.22, 144.81 -135.21, 28.45 296.48, 84.97 -57.15, -29.77 in-in in 7.6756 Saltbr-in 2.7452 HRD-in -84.66, -44.43 68.53, 7.81 in-in-out SNCiio in-out ActLoopNT-in 2.9218 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.94, 35.04 APE9-dihe-in -66.46, 139.38 APE8-dihe-in -79.29, 77.36 APE8-rot-na 30.63 APE67-dihe-in -76.81, -5.82 -62.53, -27.62 APE12-dist-na 11.2208 APE11-dist-na 12.9738 APE10-dist-na 10.2444 APE9-dist-in 6.6658 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.93 0.204 0.247 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4ivd Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4K6ZA P23458 865 1154 1154.0 1Q3:1201 Type1 Inactive DFGin 6.3683 13.6285 ABAminus -111.25, 5.81 -148.16, 138.39 -130.89, 30.06 299.5, 88.49 -54.29, -32.58 in-in in 8.1614 Saltbr-in 2.9135 HRD-in -64.09, -54.55 67.8, 5.15 in-in-out SNCiio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.94, 36.35 APE9-dihe-in -67.0, 125.07 APE8-dihe-in -75.83, 85.59 APE8-rot-na 25.89 APE67-dihe-in -67.06, -19.07 -53.74, -42.35 APE12-dist-na 10.4253 APE11-dist-na 12.5827 APE10-dist-na 10.0067 APE9-dist-in 6.0159 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.73 0.244 0.297 A 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 4k6z Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4K77A P23458 864 1154 1154.0 1Q4:1201 Type1 Inactive DFGin 6.2559 13.4641 ABAminus -120.21, 6.98 -152.33, 140.1 -135.8, 29.32 300.23, 84.02 -66.83, -17.3 in-in in 8.0423 Saltbr-in 2.62 HRD-in -83.59, -46.77 75.55, -1.36 in-in-out SNCiio in-out ActLoopNT-in 2.8065 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.78, 30.95 APE9-dihe-in -65.86, 137.27 APE8-dihe-in -79.1, 74.56 APE8-rot-na 31.39 APE67-dihe-in -73.63, -7.17 -57.69, -30.82 APE12-dist-na 11.1803 APE11-dist-na 12.7953 APE10-dist-na 9.921 APE9-dist-in 6.7505 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.4 0.193 0.251 A 302.0 284.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 4k77 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 4K77B P23458 865 1154 1154.0 1Q4:1201 Type1 Inactive DFGin 6.2823 13.5037 ABAminus -120.68, 0.99 -147.42, 142.05 -133.88, 36.74 297.84, 83.5 -67.02, -18.72 in-in in 7.9484 Saltbr-in 2.9218 HRD-in -85.03, -50.83 74.8, -3.74 in-in-out SNCiio in-out ActLoopNT-in 2.726 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -112.68, 47.05 APE9-dihe-in -77.0, 143.68 APE8-dihe-in -79.91, 78.18 APE8-rot-na 30.27 APE67-dihe-in -77.76, -4.87 -65.15, -27.78 APE12-dist-na 11.1372 APE11-dist-na 12.7263 APE10-dist-na 10.167 APE9-dist-in 6.81 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.4 0.193 0.251 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 4k77 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5HX8A P23458 855 1154 1154.0 66P:1201 Type1 Inactive DFGin 6.449 13.6875 ABAminus -102.8, 8.3 -149.54, 137.76 -131.57, 23.74 295.19, 87.44 -55.43, -25.96 in-in in 7.9251 Saltbr-in 2.7615 HRD-in -74.69, -48.9 64.93, 4.52 in-in-in SNCiii in-in ActLoopNT-in 2.7265 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.85, 104.76 APE9-dihe-in -72.26, 138.18 APE8-dihe-in -80.27, 76.7 APE8-rot-na 26.46 APE67-dihe-in -75.94, -4.44 -51.82, -37.01 APE12-dist-na 11.1195 APE11-dist-na 12.2854 APE10-dist-na 11.3929 APE9-dist-in 6.6113 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.199 0.24 A 302.0 293.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 5hx8 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5HX8B P23458 865 1154 1154.0 66P:1201 Type1 Inactive DFGin 6.4205 13.6309 ABAminus -110.45, 9.62 -150.03, 136.28 -131.01, 24.66 294.53, 92.56 -57.47, -31.3 in-in in 7.7687 Saltbr-in 2.7579 HRD-in -74.49, -50.24 68.18, -1.59 in-in-out SNCiio in-out ActLoopNT-in 2.7739 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -121.57, 40.76 APE9-dihe-in -71.94, 141.78 APE8-dihe-in -79.55, 77.3 APE8-rot-na 24.89 APE67-dihe-in -77.48, 1.58 -49.69, -36.95 APE12-dist-na 10.8376 APE11-dist-na 12.6929 APE10-dist-na 10.8601 APE9-dist-in 6.5503 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.199 0.24 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5hx8 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5WO4A P23458 854 1154 1154.0 B7V:2001 Type1 Inactive DFGin 6.5589 13.4747 ABAminus -113.4, 5.79 -147.65, 137.71 -131.93, 25.73 295.23, 90.95 -54.73, -30.34 in-in in 7.6759 Saltbr-in 2.7544 HRD-in -72.7, -46.52 67.85, -2.92 in-in-out SNCiio in-out ActLoopNT-in 2.8208 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.62, 42.17 APE9-dihe-in -67.76, 140.08 APE8-dihe-in -81.09, 72.14 APE8-rot-na 29.77 APE67-dihe-in -75.22, -1.83 -52.55, -34.79 APE12-dist-na 10.7973 APE11-dist-na 12.9011 APE10-dist-na 10.4662 APE9-dist-in 6.8227 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.84 0.188 0.211 A 302.0 294.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 5wo4 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5WO4B P23458 865 1154 1154.0 B7V:2001 Type1 Inactive DFGin 6.5504 13.4107 ABAminus -111.8, 3.6 -145.5, 139.23 -132.92, 27.81 292.27, 90.98 -57.76, -28.76 in-in in 7.6152 Saltbr-in 2.7806 HRD-in -72.82, -49.06 69.56, 1.39 in-in-out SNCiio in-out ActLoopNT-in 2.8385 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.71, 39.74 APE9-dihe-in -66.32, 138.27 APE8-dihe-in -78.58, 73.11 APE8-rot-na 28.91 APE67-dihe-in -75.88, -0.88 -52.5, -34.22 APE12-dist-na 10.8657 APE11-dist-na 12.9297 APE10-dist-na 10.505 APE9-dist-in 6.7428 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.84 0.188 0.211 B 302.0 282.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 5wo4 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6HZUA P23458 854 1154 1154.0 GYQ:61201 Type1 Inactive DFGin 6.4583 13.248 ABAminus -115.79, 10.1 -155.61, 143.2 -135.89, 34.69 298.64, 85.33 -68.92, -23.66 in-in in 7.8907 Saltbr-in 2.6049 HRD-in -70.11, -45.53 64.37, 7.1 in-in-out SNCiio in-out ActLoopNT-in 2.7677 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -94.73, 34.76 APE9-dihe-in -73.48, 139.36 APE8-dihe-in -81.86, 74.79 APE8-rot-na 30.37 APE67-dihe-in -72.43, -9.67 -55.59, -34.31 APE12-dist-na 10.9672 APE11-dist-na 13.1742 APE10-dist-na 9.8871 APE9-dist-in 6.8026 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.204 0.265 A 302.0 293.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6hzu Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6HZUB P23458 865 1154 1154.0 GYQ:61201 Type1 Inactive DFGin 6.4433 13.2473 ABAminus -119.96, 0.48 -155.13, 140.72 -132.65, 33.96 299.27, 84.27 -60.17, -34.27 in-in in 8.0228 Saltbr-in 2.7023 HRD-in -82.42, -47.78 71.93, 4.63 in-in-out SNCiio in-out ActLoopNT-in 2.9233 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -93.89, 29.59 APE9-dihe-in -63.03, 138.85 APE8-dihe-in -81.19, 78.97 APE8-rot-na 31.69 APE67-dihe-in -73.96, -7.04 -62.12, -30.09 APE12-dist-na 11.006 APE11-dist-na 13.2245 APE10-dist-na 9.8851 APE9-dist-in 6.6567 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.2 0.204 0.265 B 302.0 285.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 6hzu Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N77A P23458 866 1154 1154.0 KEJ:1201 Type1 Inactive DFGin 6.3905 13.6543 ABAminus -111.17, 5.93 -155.03, 145.91 -137.7, 32.01 295.16, 86.03 -58.79, -28.87 in-in in 8.2385 Saltbr-in 2.7578 HRD-in -67.03, -46.69 67.69, -1.58 in-in-out SNCiio in-out ActLoopNT-in 2.9237 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 52.82, 53.92 APE9-dihe-in -90.09, 140.83 APE8-dihe-in -78.25, 71.6 APE8-rot-na 26.8 APE67-dihe-in -76.7, -1.13 -52.74, -34.15 APE12-dist-na 11.0789 APE11-dist-na 12.0899 APE10-dist-na 10.9937 APE9-dist-in 7.0193 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.64 0.253 0.282 A 302.0 280.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6n77 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N77B P23458 865 1154 1154.0 KEJ:1202 Type1 Inactive DFGin 6.4472 13.754 ABAminus -112.96, 6.51 -156.54, 142.84 -135.02, 28.22 296.71, 89.38 -58.72, -26.41 in-in in 8.2129 Saltbr-in 2.7371 HRD-in -67.03, -48.62 72.63, -6.63 in-in-out SNCiio in-out ActLoopNT-in 2.8443 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -102.58, 44.0 APE9-dihe-in -74.12, 131.71 APE8-dihe-in -79.78, 70.31 APE8-rot-na 28.35 APE67-dihe-in -75.35, -3.65 -48.14, -35.74 APE12-dist-na 10.9335 APE11-dist-na 12.6892 APE10-dist-na 9.9871 APE9-dist-in 6.9541 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.64 0.253 0.282 B 302.0 279.0 11 31 31 0 [[583, 847], [875, 1151]] 2.0 6n77 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N78A P23458 866 1154 1154.0 KEP:1201 Type1 Inactive DFGin 6.4254 13.5625 ABAminus -105.81, -4.17 -146.0, 143.93 -133.35, 28.47 298.42, 87.41 -54.49, -32.74 in-in in 8.377 Saltbr-in 2.7299 HRD-in -68.76, -52.63 70.44, -3.87 in-in-in SNCiii in-in ActLoopNT-in 2.8114 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.29, 50.22 APE9-dihe-in -86.39, 131.12 APE8-dihe-in -82.28, 79.47 APE8-rot-na 24.58 APE67-dihe-in -76.5, -2.33 -53.51, -34.22 APE12-dist-na 11.515 APE11-dist-na 12.0366 APE10-dist-na 9.0523 APE9-dist-in 6.3769 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.83 0.236 0.261 A 302.0 277.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6n78 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N79A P23458 866 1154 1154.0 KES:1201 Type1 Inactive DFGin 6.4028 13.5254 ABAminus -99.38, -15.25 -133.8, 148.14 -138.23, 25.13 295.77, 92.1 -55.46, -31.57 in-in in 8.2951 Saltbr-in 2.767 HRD-in -74.33, -53.6 68.25, 4.98 in-in-out SNCiio in-out ActLoopNT-in 2.7811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -114.11, 40.21 APE9-dihe-in -76.58, 124.37 APE8-dihe-in -77.77, 81.63 APE8-rot-na 28.13 APE67-dihe-in -77.42, -2.89 -55.56, -32.1 APE12-dist-na 11.2191 APE11-dist-na 11.8873 APE10-dist-na 9.0753 APE9-dist-in 5.9643 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.27 0.227 0.27 A 302.0 279.0 10 31 29 2 [[583, 847], [875, 1151]] 2.0 6n79 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N7BA P23458 865 1154 1154.0 KEY:1201 Type1 Inactive DFGin 6.4505 13.4556 ABAminus -106.32, -1.48 -152.36, 145.64 -135.47, 28.3 291.96, 86.78 -55.73, -29.48 in-in in 7.7359 Saltbr-in 2.7685 HRD-in -71.34, -49.85 67.55, 5.37 in-in-in SNCiii in-in ActLoopNT-in 2.8058 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.89, 58.14 APE9-dihe-in -96.67, 129.96 APE8-dihe-in -81.34, 78.4 APE8-rot-na 26.42 APE67-dihe-in -77.54, 0.39 -57.77, -29.15 APE12-dist-na 11.0589 APE11-dist-na 11.7277 APE10-dist-na 8.7902 APE9-dist-in 6.3688 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.81 0.222 0.264 A 302.0 280.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7b Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N7CA P23458 865 1154 1154.0 KF1:1201 Type1 Inactive DFGin 6.5135 13.5086 ABAminus -110.36, 6.26 -156.68, 145.17 -136.24, 27.53 295.08, 89.21 -55.95, -29.39 in-in in 8.0959 Saltbr-in 2.7352 HRD-in -68.7, -46.37 70.89, -7.05 in-in-none SNCiin in-none ActLoopNT-in 2.9025 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 95.97 APE9-dihe-in -107.06, 147.5 APE8-dihe-in -79.03, 70.75 APE8-rot-na 27.77 APE67-dihe-in -74.72, -3.56 -53.55, -33.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.4569 APE9-dist-in 7.0847 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.69 0.254 0.288 A 302.0 275.0 15 31 29 2 [[583, 847], [875, 1151]] 2.0 6n7c Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N7CB P23458 865 1154 1154.0 KF1:1202 Type1 Inactive DFGin 6.5102 13.5888 ABAminus -115.1, 6.45 -153.47, 142.93 -133.09, 25.34 294.67, 85.94 -52.61, -29.28 in-in in 8.1554 Saltbr-in 2.7529 HRD-in -67.82, -44.9 68.03, -6.1 in-in-none SNCiin in-none ActLoopNT-in 2.8609 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.81 APE8-dihe-in -80.52, 71.8 APE8-rot-na 28.74 APE67-dihe-in -72.99, -4.02 -55.65, -32.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.1147 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.69 0.254 0.288 B 302.0 273.0 17 31 27 4 [[583, 847], [875, 1151]] 2.0 6n7c Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N7DA P23458 865 1154 1154.0 KF4:1201 Type1 Inactive DFGin 6.4763 13.4019 ABAminus -110.67, 4.22 -155.59, 141.48 -134.23, 27.49 295.25, 85.51 -53.77, -30.29 in-in in 8.2846 Saltbr-in 2.6373 HRD-in -73.25, -49.17 70.77, 0.44 in-in-out SNCiio in-out ActLoopNT-in 2.8216 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.59, 31.0 APE9-dihe-in -83.57, 124.64 APE8-dihe-in -81.68, 83.11 APE8-rot-na 27.61 APE67-dihe-in -75.33, -0.8 -58.46, -31.26 APE12-dist-na 11.5609 APE11-dist-na 11.7371 APE10-dist-na 7.5838 APE9-dist-in 5.9758 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.78 0.198 0.234 A 302.0 280.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7d Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSBA P23458 865 1154 1154.0 KGZ:1201 Type1 Inactive DFGin 6.5897 13.5094 ABAminus -116.74, 1.69 -150.38, 137.57 -126.94, 22.04 292.38, 82.89 -70.44, -11.55 in-in in 8.1068 Saltbr-in 2.6145 HRD-in -82.35, -48.96 71.74, 9.14 in-in-out SNCiio in-out ActLoopNT-in 2.8445 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -106.58, 28.79 APE9-dihe-in -52.22, 132.79 APE8-dihe-in -77.89, 76.1 APE8-rot-na 36.11 APE67-dihe-in -73.96, -4.25 -64.89, -26.96 APE12-dist-na 12.0373 APE11-dist-na 12.29 APE10-dist-na 10.3273 APE9-dist-in 6.8845 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.311 0.354 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsb Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSBB P23458 865 1154 1154.0 KGZ:1201 Type1 Inactive DFGin 6.6473 13.9041 ABAminus -118.58, -5.18 -147.32, 138.8 -128.6, 27.58 293.53, 77.97 -68.36, -16.41 in-in in 8.0489 Saltbr-in 2.7074 HRD-in -76.09, -52.98 75.83, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.9586 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.45, 33.45 APE9-dihe-in -55.89, 141.48 APE8-dihe-in -80.12, 75.54 APE8-rot-na 36.76 APE67-dihe-in -74.19, -3.49 -57.35, -33.46 APE12-dist-na 11.7916 APE11-dist-na 12.9425 APE10-dist-na 10.1411 APE9-dist-in 6.8514 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.311 0.354 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsb Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSCA P23458 865 1154 1154.0 KH5:1201 Type1 Inactive DFGin 6.5538 13.4092 ABAminus -117.31, 8.47 -153.39, 137.28 -129.48, 30.56 297.53, 83.92 -65.76, -23.88 in-in in 7.6629 Saltbr-in 2.6894 HRD-in -79.6, -49.32 70.06, 11.43 in-in-out SNCiio in-out ActLoopNT-in 2.7172 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -98.9, 27.5 APE9-dihe-in -67.04, 137.63 APE8-dihe-in -80.21, 78.36 APE8-rot-na 37.08 APE67-dihe-in -76.89, -0.21 -62.94, -28.86 APE12-dist-na 11.0035 APE11-dist-na 13.5759 APE10-dist-na 10.2308 APE9-dist-in 6.8584 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.249 0.28 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsc Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSCB P23458 865 1154 1154.0 KH5:1201 Type1 Inactive DFGin 6.5561 13.712 ABAminus -118.51, -2.16 -150.35, 139.43 -132.07, 31.9 298.68, 77.43 -57.63, -28.0 in-in in 7.9025 Saltbr-in 2.662 HRD-in -78.87, -51.69 73.77, 10.39 in-in-out SNCiio in-out ActLoopNT-in 2.9169 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.91, 33.47 APE9-dihe-in -66.35, 135.05 APE8-dihe-in -77.66, 75.63 APE8-rot-na 31.23 APE67-dihe-in -74.4, -5.72 -63.02, -28.16 APE12-dist-na 11.1417 APE11-dist-na 13.5111 APE10-dist-na 10.263 APE9-dist-in 6.9184 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.249 0.28 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsc Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSDA P23458 865 1154 1154.0 KH8:1201 Type1 Inactive DFGin 6.5627 13.2902 ABAminus -121.03, 3.28 -150.09, 139.62 -132.15, 26.01 293.71, 87.42 -59.82, -26.08 in-in in 7.6415 Saltbr-in 2.673 HRD-in -81.56, -47.83 71.88, 7.09 in-in-out SNCiio in-out ActLoopNT-in 2.9247 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.0, 23.61 APE9-dihe-in -58.47, 136.99 APE8-dihe-in -79.35, 76.48 APE8-rot-na 35.13 APE67-dihe-in -77.95, -0.82 -64.48, -27.09 APE12-dist-na 11.0296 APE11-dist-na 13.5683 APE10-dist-na 10.219 APE9-dist-in 6.8056 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.76 0.202 0.238 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsd Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSDB P23458 865 1154 1154.0 KH8:1201 Type1 Inactive DFGin 6.5671 13.4201 ABAminus -123.92, 1.98 -149.52, 139.04 -133.17, 29.94 296.8, 84.79 -64.12, -24.87 in-in in 7.8281 Saltbr-in 2.6195 HRD-in -81.48, -52.31 73.66, 6.38 in-in-out SNCiio in-out ActLoopNT-in 2.8857 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 78.39, 5.73 APE9-dihe-in -59.21, 132.36 APE8-dihe-in -78.28, 75.83 APE8-rot-na 31.46 APE67-dihe-in -72.63, -5.35 -64.01, -28.2 APE12-dist-na 11.2098 APE11-dist-na 13.5281 APE10-dist-na 10.362 APE9-dist-in 6.8871 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.76 0.202 0.238 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsd Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSEA P23458 865 1154 1154.0 KHH:1201 Type1 Inactive DFGin 6.5368 13.3482 ABAminus -113.91, 1.27 -156.33, 137.23 -131.71, 27.09 299.32, 82.9 -56.09, -32.48 in-in in 7.8643 Saltbr-in 2.6378 HRD-in -79.69, -48.26 69.1, 11.16 in-in-out SNCiio in-out ActLoopNT-in 2.7164 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -68.92, 43.15 APE9-dihe-in -70.68, 135.44 APE8-dihe-in -74.14, 74.71 APE8-rot-na 28.88 APE67-dihe-in -82.04, -6.18 -60.6, -28.4 APE12-dist-na 9.3275 APE11-dist-na 11.7818 APE10-dist-na 10.4664 APE9-dist-in 6.774 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.265 0.303 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rse Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSEB P23458 865 1154 1154.0 KHH:1201 Type1 Inactive DFGin 6.4607 13.5688 ABAminus -119.02, 6.25 -155.18, 136.02 -130.8, 28.87 296.2, 78.44 -57.74, -31.19 in-in in 8.0339 Saltbr-in 2.5795 HRD-in -78.09, -47.4 66.03, 12.85 in-in-out SNCiio in-out ActLoopNT-in 2.9031 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -77.34, 48.11 APE9-dihe-in -88.98, 140.2 APE8-dihe-in -76.8, 76.65 APE8-rot-na 33.64 APE67-dihe-in -80.09, -3.14 -61.43, -26.93 APE12-dist-na 13.3249 APE11-dist-na 11.8334 APE10-dist-na 10.7555 APE9-dist-in 6.8555 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.8 0.265 0.303 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rse Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSHA P23458 865 1154 1154.0 KHE:1201 Type1 Inactive DFGin 6.6345 13.4865 ABAminus -113.16, 6.59 -151.95, 137.99 -130.33, 27.13 294.82, 88.08 -65.9, -20.74 in-in in 7.4405 Saltbr-in 2.5318 HRD-in -77.26, -48.19 64.78, 14.62 in-in-out SNCiio in-out ActLoopNT-in 2.6944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 87.06, 32.22 APE9-dihe-in -74.25, 135.13 APE8-dihe-in -77.78, 76.14 APE8-rot-na 33.2 APE67-dihe-in -80.47, -5.2 -61.66, -26.89 APE12-dist-na 11.1674 APE11-dist-na 12.6391 APE10-dist-na 10.2352 APE9-dist-in 6.904 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.71 0.271 0.311 A 302.0 286.0 4 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsh Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6RSHB P23458 865 1154 1154.0 KHE:1201 Type1 Inactive DFGin 6.627 13.8518 ABAminus -116.98, -3.62 -146.38, 138.52 -131.28, 30.89 293.47, 79.95 -64.48, -19.44 in-in in 7.784 Saltbr-in 2.3752 HRD-in -81.26, -46.13 68.12, 10.14 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 90.62, 16.91 APE9-dihe-in -58.11, 134.31 APE8-dihe-in -78.21, 75.43 APE8-rot-na 34.5 APE67-dihe-in -75.52, -2.49 -58.55, -33.71 APE12-dist-na 11.2189 APE11-dist-na 13.047 APE10-dist-na 10.4487 APE9-dist-in 6.9603 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.71 0.271 0.311 B 302.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 6rsh Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6SM8A P23458 854 1154 1154.0 LKT:61201 Type1 Inactive DFGin 6.8129 13.706 ABAminus -101.63, -7.1 -147.81, 142.33 -131.41, 24.39 292.89, 86.49 -54.23, -31.63 in-in in 7.8069 Saltbr-in 2.7315 HRD-in -72.9, -49.47 70.53, 3.61 in-in-out SNCiio in-out ActLoopNT-in 2.8357 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -103.89, 30.48 APE9-dihe-in -64.02, 138.21 APE8-dihe-in -82.49, 73.83 APE8-rot-na 29.16 APE67-dihe-in -76.27, -2.8 -50.53, -32.36 APE12-dist-na 11.4381 APE11-dist-na 13.2197 APE10-dist-na 10.2463 APE9-dist-in 6.7238 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.85 0.213 0.241 A 302.0 296.0 5 31 31 0 [[583, 847], [875, 1151]] 2.0 6sm8 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 8S85A P23458 854 1154 1154.0 A1H5R:61201 Type1 Inactive DFGin 6.6301 13.3454 ABAminus -112.23, -7.17 -149.03, 146.72 -132.22, 30.5 297.85, 84.4 -54.75, -31.9 in-in in 7.8523 Saltbr-in 2.6184 HRD-in -76.09, -48.85 71.09, 5.36 in-in-out SNCiio in-out ActLoopNT-in 2.8373 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 58.53, 30.92 APE9-dihe-in -76.65, 137.48 APE8-dihe-in -75.77, 75.79 APE8-rot-na 30.15 APE67-dihe-in -76.06, -7.29 -58.07, -32.61 APE12-dist-na 11.2659 APE11-dist-na 12.6789 APE10-dist-na 10.4668 APE9-dist-in 6.8782 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.75 0.21 0.25 A 302.0 292.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 8s85 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 8S85B P23458 865 1154 1154.0 A1H5R:61201 Type1 Inactive DFGin 6.6963 13.3555 ABAminus -114.2, -1.94 -152.98, 142.26 -130.74, 31.83 294.81, 85.33 -58.52, -32.2 in-in in 7.7445 Saltbr-in 2.6138 HRD-in -77.39, -48.2 72.5, 8.27 in-in-out SNCiio in-out ActLoopNT-in 2.8906 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -105.67, 37.06 APE9-dihe-in -66.96, 136.92 APE8-dihe-in -79.85, 74.06 APE8-rot-na 34.04 APE67-dihe-in -73.04, -6.17 -58.28, -33.1 APE12-dist-na 11.159 APE11-dist-na 13.0981 APE10-dist-na 10.4532 APE9-dist-in 6.7965 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.75 0.21 0.25 B 302.0 283.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 8s85 Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N7AA P23458 865 1154 1154.0 KEV:61203 Type1 Inactive DFGin 6.4526 13.3666 ABAminus -116.98, 9.47 -160.4, 147.32 -135.39, 27.13 297.85, 83.25 -58.95, -23.42 in-in in 7.7452 Saltbr-in 2.7564 HRD-in -75.17, -44.67 72.8, -4.01 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.07, 124.84 APE9-dihe-in -104.44, 150.91 APE8-dihe-in -83.53, 72.06 APE8-rot-na 34.1 APE67-dihe-in -76.43, -2.54 -56.05, -29.88 APE12-dist-na 14.6585 APE11-dist-na 9.2784 APE10-dist-na 12.111 APE9-dist-in 7.138 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 A 304.0 278.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6N7AB P23458 854 1154 1154.0 KEV:61202 Type1 Inactive DFGin 6.4703 13.4982 ABAminus -116.23, 10.2 -162.11, 148.53 -137.01, 27.49 296.62, 85.6 -60.22, -22.88 in-in in 7.7761 Saltbr-in 2.7552 HRD-in -73.34, -48.05 70.64, 1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8043 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.78, 65.84 APE9-dihe-in -92.65, 132.46 APE8-dihe-in -84.19, 73.36 APE8-rot-na 33.1 APE67-dihe-in -76.82, -1.21 -55.1, -31.23 APE12-dist-na 10.789 APE11-dist-na 11.6888 APE10-dist-na 9.266 APE9-dist-in 6.8188 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 1.33 0.192 0.207 B 304.0 291.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 6n7a Homo sapiens TYR_JAK1-2_HUMAN TYR 2.2e-87 298.6 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5KHXA P23458 867 1154 1154.0 6TE:4000 Type1 Inactive DFGin 6.6313 13.5403 ABAminus -113.66, 8.44 -153.85, 134.53 -126.55, 25.21 296.38, 85.41 -59.93, -18.33 in-in in 7.5652 Saltbr-in 2.7784 HRD-in -73.12, -47.99 66.65, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.92, 156.56 APE9-dihe-in -137.25, 140.8 APE8-dihe-in -82.8, 71.88 APE8-rot-na 32.82 APE67-dihe-in -77.93, -4.04 -54.17, -30.94 APE12-dist-na 14.2539 APE11-dist-na 8.4657 APE10-dist-na 10.4355 APE9-dist-in 6.3762 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.4 0.173 0.242 A 316.0 278.0 10 31 31 0 [[583, 847], [875, 1151]] 2.0 5khx Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6BBUA P23458 867 1154 1154.0 D7D:4000 Type1 Inactive DFGin 6.4193 13.3 ABAminus -116.63, 12.94 -152.79, 140.28 -132.74, 24.58 296.65, 83.13 -57.55, -25.0 in-in in 7.6445 Saltbr-in 2.7807 HRD-in -73.12, -50.44 71.69, 3.72 in-in-in SNCiii in-in ActLoopNT-in 2.8608 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -135.84, 101.53 APE9-dihe-in -119.31, 160.09 APE8-dihe-in -78.32, 76.15 APE8-rot-na 30.95 APE67-dihe-in -74.07, -7.36 -55.8, -32.39 APE12-dist-na 9.7484 APE11-dist-na 11.1833 APE10-dist-na 11.2989 APE9-dist-in 6.2631 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.08 0.185 0.213 A 316.0 281.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6bbu Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6DBNA P23458 867 1154 1154.0 G4J:4000 Type1 Inactive DFGin 6.3393 13.2699 ABAminus -106.28, 2.12 -151.4, 144.25 -137.1, 32.6 295.8, 96.91 -66.86, -18.69 in-in in 7.5962 Saltbr-in 2.792 HRD-in -66.34, -50.63 70.35, -1.99 in-in-in SNCiii in-in ActLoopNT-in 2.8102 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -142.87, 84.26 APE9-dihe-in -94.42, 151.25 APE8-dihe-in -77.55, 83.04 APE8-rot-na 28.37 APE67-dihe-in -75.2, -10.39 -60.86, -28.98 APE12-dist-na 9.3019 APE11-dist-na 11.0309 APE10-dist-na 10.8091 APE9-dist-in 6.0103 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.48 0.19 0.262 A 316.0 281.0 7 31 31 0 [[583, 847], [875, 1151]] 2.0 6dbn Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 6W8LA P23458 867 1154 1154.0 R4S:1201 Type1 Inactive DFGin 6.5203 13.6387 ABAminus -117.57, 7.4 -146.11, 138.04 -131.96, 25.84 294.24, 93.82 -58.79, -29.12 in-in in 7.6993 Saltbr-in 2.7472 HRD-in -65.59, -50.27 70.66, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.7962 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -75.31, 154.48 APE9-dihe-in -145.69, 148.21 APE8-dihe-in -75.35, 73.33 APE8-rot-na 31.68 APE67-dihe-in -71.12, -8.39 -52.84, -34.47 APE12-dist-na 13.7303 APE11-dist-na 8.0423 APE10-dist-na 10.4812 APE9-dist-in 6.4005 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.11 0.197 0.226 A 316.0 280.0 8 31 31 0 [[583, 847], [875, 1151]] 2.0 6w8l Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5KHWB P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.1878 13.7874 BLAminus -126.62, -174.05 50.66, 92.23 -105.71, 28.99 301.42, 97.18 -62.73, -33.32 in-in in 7.9908 Saltbr-in 2.817 HRD-in -54.38, -55.02 75.74, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -83.14, 18.97 APE9-dihe-in -58.32, 113.18 APE8-dihe-in -82.04, 77.86 APE8-rot-na 28.29 APE67-dihe-in -76.85, -3.42 -56.14, -32.61 APE12-dist-na 7.879 APE11-dist-na 9.6953 APE10-dist-na 6.6047 APE9-dist-in 5.9119 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 B 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
JAK1-2 JAK1_HUMAN 5E1EA P23458 865 1154 1154.0 5JG:1202 Type1 Inactive DFGin 6.6436 13.9325 BLAminus -119.33, -177.28 50.16, 87.79 -101.77, 31.05 290.94, 82.42 -65.82, -24.94 in-in in 7.8719 Saltbr-in 2.7937 HRD-in -75.04, -43.37 64.83, -0.01 in-in-out SNCiio in-out ActLoopNT-in 2.8156 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -107.99, 41.3 APE9-dihe-in -73.96, 132.79 APE8-dihe-in -79.05, 75.13 APE8-rot-na 22.09 APE67-dihe-in -75.65, -2.64 -52.7, -35.87 APE12-dist-na 10.9808 APE11-dist-na 12.9477 APE10-dist-na 10.1677 APE9-dist-in 6.9083 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.3 0.227 0.268 A 290.0 281.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5e1e Homo sapiens TYR_JAK1-2_HUMAN TYR 1.9e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1

TYR_JAK1-2 (Tyrosine-protein kinase JAK1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name