4E3C

IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)
Group: OTHER
Uniprot: IKKB_HUMAN
Organism: Homo sapiens
Domain boundary: 15 - 308
Resolu: 3.98

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None in-in in-out No_ligand No_ligand 16 - 665 0
B Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 16 - 665 0
C Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 16 - 665 0
D Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 16 - 665 0
E Inactive DFGin None in-in in-out No_ligand No_ligand 16 - 665 0
F Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 16 - 665 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain F
         -         20         30         40 
nlyfqgamgs tcgawEMKER LGTGGFGNVI RWHNQETGEQ 
        50         60         70         80 
IAIKQCRQEL SPRNRERWCL EIQIMRRLTH PNVVAARDVP 
        90        100        110        120 
EGMQNLAPND LPLLAMEYCQ GGDLRKYLNQ FENCCGLREG 
       130        140        150        160 
AILTLLSDIA SALRYLHENR IIHRDLKPEN IVLQQGEQRL 
       170        180        190        200 
IHKIIDLGYA KELDQGELCT EFVGTLQYLA PELLEQQKYT 
       210        220        230        240 
VTVDYWSFGT LAFECITGFR PFLPNWQPVQ WHSKVRQKSE 
       250        260        270        280 
VDIVVSEDLN GTVKFSSSLP YPNNLNSVLA ERLEKWLQLM 
       290        300        310        320 
LMWHPRqrgT DPTYGPNGCF KALDDILNLK LVHILNMVTG 
       330        340        350        360 
TIHTYPVTED ESLQSLKARI QQDTGIPEED QELLQEAGLA 
       370        380        390        400 
LIPDKPATQC ISDgklnegh tlDMDLVFLF DNSKityetq 
       410        420        430        440 
ISPRPQPESV SCILQEPKRN LAFFQLRKVW GQVWHSIQTL 
       450        460        470        480 
KEDCNRLQQG QRAAMMNLLR NNSCLSKMKN SMASMSQQLK 
       490        500        510        520 
AKLDFFKTSI QIDLEKYSEQ TEFGITSDKL LLAWREMEQA 
       530        540        550        560 
VELCGRENEV KLLVERMMAL QTDIVDLQRS pmgrkqggTL 
       570        580        590        600 
DDLEEQAREL YRRLREKPRD QRTEGDSQEM VRLLLQAIQS 
       610        620        630        640 
FEKKVRVIYT QLSKTVVCKQ KALELLPKVE EVVSLMNEDE 
       650        660 
KTVVRLQEKR QKELWNLLKI ACSKVrgpv
Lower-case residues are disordered in structure.
Mutations: S177E,S181E
Phosphorylation: None