OTHER_IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)

Total number of chains: 15
Active chains: 3
Uniprot: IKKB_HUMAN
Kinase Domain Residues: 15 - 308
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 66.7% AF-O14920-K1A
DFGin None 2 13.3% 4E3CA
DFGin BLBminus 1 6.7% 8OMVB
DFGinter None 1 6.7% 8OMVE
None None 1 6.7% 8OMVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
IKBKB AF-O14920-K1A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.7517 12.4893 BLAminus -126.26, 179.48 57.5, 66.07 -76.3, 19.61 299.61, 8.49 -59.99, -32.45 in-in in 8.2391 Saltbr-in 2.629 HRD-in -81.33, -51.39 65.56, 14.54 in-in-in SNCiii in-in ActLoopNT-in 2.9645 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.53, 154.84 APE9-dihe-na 116.37, 176.3 APE8-dihe-in -92.66, 124.92 APE8-rot-in 300.66 APE67-dihe-in -71.88, -14.8 -44.22, -44.73 APE12-dist-in 8.6962 APE11-dist-in 11.3046 APE10-dist-in 5.5182 APE9-dist-in 3.4041 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 27 27 0 [[15, 449]] 1.0 AF-O14920-K1 OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB AF-O14920-K3A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.5819 12.3433 BLAminus -132.39, 175.64 61.02, 71.13 -79.51, 18.58 302.46, 7.63 -62.8, -20.15 in-in in 8.2808 Saltbr-in 2.6732 HRD-in -75.95, -49.61 66.27, 1.06 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.0, 159.82 APE9-dihe-na 103.19, -179.04 APE8-dihe-in -94.98, 120.71 APE8-rot-in 301.22 APE67-dihe-in -70.58, -17.32 -47.51, -36.7 APE12-dist-in 8.7646 APE11-dist-in 11.1224 APE10-dist-in 5.289 APE9-dist-in 3.4445 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 27 27 0 [[15, 449]] 1.0 AF-O14920-K3 OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4KIKB O14920 2 663 756.0 KSA:60700 Type1 Active DFGin 5.8841 12.1525 BLAminus -125.87, 177.92 56.45, 91.03 -106.12, 30.12 279.95, 121.49 -75.67, -15.82 in-in in 8.4336 Saltbr-in 3.0235 HRD-in -64.36, -54.26 72.29, -3.36 in-in-in SNCiii in-in ActLoopNT-in 3.0741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.33, 150.83 APE9-dihe-na 128.58, -160.18 APE8-dihe-in -124.05, 125.13 APE8-rot-in 284.23 APE67-dihe-in -62.44, -27.05 -45.7, -44.8 APE12-dist-in 7.899 APE11-dist-in 11.0492 APE10-dist-in 5.0684 APE9-dist-in 3.4557 None SEP177,SEP181 SEP177,SEP181 XRAY 2.83 0.186 0.236 B 677.0 649.0 3 27 24 3 [[15, 449]] 1.0 4kik OTHER_IKBKB_HUMAN OTHER 1.1e-50 180.0 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4E3CB O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.7231 12.4163 BLAminus -105.72, -155.63 -11.15, 130.65 -122.44, 23.83 259.84, 47.47 -53.22, -19.06 in-in in 8.4721 Saltbr-in 2.7706 HRD-in -75.6, -33.93 66.41, -70.8 in-in-out SNCiio in-out ActLoopNT-in 2.8748 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -41.33, 120.77 APE9-dihe-na 145.43, -135.28 APE8-dihe-in -71.19, 72.96 APE8-rot-in 313.16 APE67-dihe-out 41.01, -82.54 -50.74, -88.53 APE12-dist-in 8.1682 APE11-dist-out 7.7771 APE10-dist-out 11.4687 APE9-dist-out 12.7616 S177E,S181E None None XRAY 3.98 0.267 0.299 B 669.0 632.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4E3CC O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.7051 12.3482 BLAminus -106.09, -155.19 -11.21, 130.09 -121.05, 26.29 258.84, 49.2 -40.6, -84.85 in-in in 8.4622 Saltbr-in 2.7612 HRD-in -71.79, -36.13 68.15, -71.55 in-in-out SNCiio in-out ActLoopNT-in 2.6523 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -85.59, 121.05 APE9-dihe-na 114.45, 160.33 APE8-dihe-out -45.72, -30.46 APE8-rot-out 41.29 APE67-dihe-out -70.56, -0.85 47.27, 14.31 APE12-dist-in 8.1115 APE11-dist-in 10.92 APE10-dist-out 8.1558 APE9-dist-out 11.1496 S177E,S181E None None XRAY 3.98 0.267 0.299 C 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4E3CD O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.7967 12.4624 BLAminus -105.23, -154.26 -12.01, 129.89 -121.15, 31.39 257.96, 46.78 -48.12, -73.54 in-in in 8.4714 Saltbr-in 2.7476 HRD-in -71.85, -36.56 68.87, -68.74 in-in-out SNCiio in-out ActLoopNT-in 2.7073 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.45, 136.63 APE9-dihe-na 128.45, -179.44 APE8-dihe-in -65.09, 82.14 APE8-rot-in 325.06 APE67-dihe-in -46.95, -54.94 -65.9, -0.17 APE12-dist-out 6.6721 APE11-dist-in 10.406 APE10-dist-out 10.2423 APE9-dist-out 11.628 S177E,S181E None None XRAY 3.98 0.267 0.299 D 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4E3CF O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.6959 12.4712 BLAminus -105.36, -154.55 -11.85, 129.86 -122.15, 25.59 260.49, 46.17 -49.15, -47.61 in-in in 8.513 Saltbr-in 2.7733 HRD-in -73.41, -32.98 66.19, -71.94 in-in-out SNCiio in-out ActLoopNT-in 2.8623 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -67.61, 80.78 APE9-dihe-na 112.37, -167.24 APE8-dihe-in -59.27, 163.67 APE8-rot-in 314.68 APE67-dihe-in -41.53, -27.23 -138.25, 21.39 APE12-dist-in 9.3987 APE11-dist-in 9.604 APE10-dist-out 8.5263 APE9-dist-out 13.0124 S177E,S181E None None XRAY 3.98 0.267 0.299 F 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 8OMVC O14920 12 664 756.0 No_ligand No_ligand Inactive DFGin 8.0964 11.319 BLAminus -107.88, 165.55 59.11, 66.52 -75.63, 95.07 269.65, 121.32 -77.03, -67.33 in-out in 8.4903 Saltbr-out 6.4234 HRD-in -72.03, -37.96 70.51, -11.08 out-out-out SNCooo out-out ActLoopNT-out 4.0882 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 160.41 APE9-dihe-na 157.46, -124.88 APE8-dihe-in -136.31, 148.05 APE8-rot-out 62.18 APE67-dihe-out -121.08, -66.51 -95.21, 70.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.9593 APE9-dist-out 9.5088 S177E,S181E None None XRAY 4.16 0.259 0.299 C 671.0 630.0 13 27 20 7 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 8OMVD O14920 6 665 756.0 No_ligand No_ligand Inactive DFGin 7.863 11.9364 BLAminus -105.3, 164.79 60.63, 66.88 -81.0, 63.33 264.63, 107.01 -73.78, -34.0 in-out in 9.2733 Saltbr-out 4.7503 HRD-in -72.17, -36.92 69.94, -10.55 out-out-out SNCooo out-out ActLoopNT-out 4.3343 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niio APE10-dihe-na -141.13, 136.52 APE9-dihe-na 129.04, 163.75 APE8-dihe-in -138.59, 89.42 APE8-rot-out 174.05 APE67-dihe-out -100.49, -35.82 -139.2, 164.47 APE12-dist-none 999.0 APE11-dist-in 11.2914 APE10-dist-in 6.9096 APE9-dist-out 9.0653 S177E,S181E None None XRAY 4.16 0.259 0.299 D 671.0 638.0 12 27 19 8 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4KIKA O14920 9 663 756.0 KSA:60800 Type1 Inactive DFGin 6.178 12.724 BLAminus -127.36, 175.43 56.16, 79.78 -104.55, 41.64 323.18, 179.99 -47.28, 146.96 in-in in 8.4631 Saltbr-in 2.9853 HRD-in -64.56, -53.95 76.42, -28.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.34, -25.34 APE9-dihe-na -61.49, -48.74 APE8-dihe-out -60.84, -33.61 APE8-rot-out 70.5 APE67-dihe-in -55.1, -27.97 -77.97, -16.15 APE12-dist-out 22.3784 APE11-dist-out 21.1544 APE10-dist-out 23.5621 APE9-dist-out 12.5036 None SEP257 SEP257 XRAY 2.83 0.186 0.236 A 677.0 619.0 17 27 17 10 [[15, 449]] 1.0 4kik OTHER_IKBKB_HUMAN OTHER 1.1e-50 180.0 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 8OMVB O14920 8 664 756.0 No_ligand No_ligand Inactive DFGin 7.6178 11.2823 BLBminus -108.54, 168.08 59.13, 68.65 -71.93, 172.37 306.75, 9.62 -115.69, -132.64 in-out in 9.6848 Saltbr-out 3.9373 HRD-in -72.28, -37.94 70.43, -9.98 out-out-out SNCooo out-out ActLoopNT-out 5.5919 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -5.22 APE9-dihe-na -138.83, -131.22 APE8-dihe-in -157.95, 113.56 APE8-rot-in 300.65 APE67-dihe-out -99.01, -1.05 179.64, 158.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1428 APE9-dist-out 9.7628 S177E,S181E None None XRAY 4.16 0.259 0.299 B 671.0 641.0 16 27 18 9 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4E3CA O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9293 12.5145 None -102.89, -152.86 -13.03, 129.81 -123.22, 17.82 259.81, 46.81 -50.25, -6.57 in-in in 8.4978 Saltbr-in 2.7367 HRD-in -75.26, -33.92 66.88, -70.59 in-in-out SNCiio in-out ActLoopNT-in 2.667 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na 54.47, 176.72 APE9-dihe-na 61.59, 168.61 APE8-dihe-out -55.76, -20.8 APE8-rot-out 96.27 APE67-dihe-out -19.53, -58.21 71.19, -31.91 APE12-dist-in 7.8908 APE11-dist-in 11.3832 APE10-dist-out 9.7094 APE9-dist-out 11.5196 S177E,S181E None None XRAY 3.98 0.267 0.299 A 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 4E3CE O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9501 12.2838 None -103.98, -153.14 -13.07, 129.81 -119.97, 29.25 259.42, 48.55 -39.7, -60.66 in-in in 8.4922 Saltbr-in 2.789 HRD-in -74.27, -34.04 66.66, -69.45 in-in-out SNCiio in-out ActLoopNT-in 2.7665 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -137.36, 34.73 APE9-dihe-na -147.47, 29.61 APE8-dihe-out 50.03, 13.62 APE8-rot-out 70.79 APE67-dihe-out 72.17, -45.62 58.67, -106.57 APE12-dist-in 7.8793 APE11-dist-in 9.547 APE10-dist-out 9.1157 APE9-dist-out 10.7947 S177E,S181E None None XRAY 3.98 0.267 0.299 E 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 8OMVE O14920 9 643 756.0 No_ligand No_ligand Inactive DFGinter 7.5361 10.9015 None -105.5, 166.4 59.46, 69.27 -69.45, 93.59 281.39, 127.96 -78.86, -65.73 in-out in 9.1681 Saltbr-out 4.7128 HRD-in -72.45, -37.03 70.29, -11.28 out-out-out SNCooo out-out ActLoopNT-out 4.6819 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -157.14, 127.84 APE9-dihe-na -150.61, -127.8 APE8-dihe-out -138.47, -162.6 APE8-rot-out 59.63 APE67-dihe-in -96.12, -64.95 -135.66, 0.49 APE12-dist-in 9.5508 APE11-dist-in 11.2015 APE10-dist-in 7.7925 APE9-dist-out 7.8966 S177E,S181E None None XRAY 4.16 0.259 0.299 E 671.0 566.0 10 27 24 3 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB 8OMVA O14920 8 666 756.0 No_ligand No_ligand Inactive None 999.0 999.0 None -106.7, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.6574 Saltbr-in 3.5262 HRD-in -71.9, -36.83 70.31, -11.77 in-out-out SNCioo out-out ActLoopNT-out 4.0623 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.13 APE8-dihe-out -137.8, 28.35 APE8-rot-in 324.42 APE67-dihe-in -67.65, -38.83 -135.68, -11.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0052 S177E,S181E None None XRAY 4.16 0.259 0.299 A 671.0 636.0 19 27 14 13 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta

OTHER_IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)

Total number of chains: 15
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 10 66.7% AF-O14920-K1A
DFGin None 2 13.3% 4E3CA
DFGin BLBminus 1 6.7% 8OMVB
DFGinter None 1 6.7% 8OMVE
None None 1 6.7% 8OMVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
IKBKB IKKB_HUMAN AF-O14920-K1A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.7517 12.4893 BLAminus -126.26, 179.48 57.5, 66.07 -76.3, 19.61 299.61, 8.49 -59.99, -32.45 in-in in 8.2391 Saltbr-in 2.629 HRD-in -81.33, -51.39 65.56, 14.54 in-in-in SNCiii in-in ActLoopNT-in 2.9645 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.53, 154.84 APE9-dihe-na 116.37, 176.3 APE8-dihe-in -92.66, 124.92 APE8-rot-in 300.66 APE67-dihe-in -71.88, -14.8 -44.22, -44.73 APE12-dist-in 8.6962 APE11-dist-in 11.3046 APE10-dist-in 5.5182 APE9-dist-in 3.4041 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 27 27 0 [[15, 449]] 1.0 AF-O14920-K1 Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN AF-O14920-K3A O14920 7 316 756.0 No_ligand No_ligand Active DFGin 5.5819 12.3433 BLAminus -132.39, 175.64 61.02, 71.13 -79.51, 18.58 302.46, 7.63 -62.8, -20.15 in-in in 8.2808 Saltbr-in 2.6732 HRD-in -75.95, -49.61 66.27, 1.06 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.0, 159.82 APE9-dihe-na 103.19, -179.04 APE8-dihe-in -94.98, 120.71 APE8-rot-in 301.22 APE67-dihe-in -70.58, -17.32 -47.51, -36.7 APE12-dist-in 8.7646 APE11-dist-in 11.1224 APE10-dist-in 5.289 APE9-dist-in 3.4445 None None None AF2 -1.0 1.0 1.0 A 310.0 310.0 0 27 27 0 [[15, 449]] 1.0 AF-O14920-K3 Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.1e-51 181.8 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4KIKB O14920 2 663 756.0 KSA:60700 Type1 Active DFGin 5.8841 12.1525 BLAminus -125.87, 177.92 56.45, 91.03 -106.12, 30.12 279.95, 121.49 -75.67, -15.82 in-in in 8.4336 Saltbr-in 3.0235 HRD-in -64.36, -54.26 72.29, -3.36 in-in-in SNCiii in-in ActLoopNT-in 3.0741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.33, 150.83 APE9-dihe-na 128.58, -160.18 APE8-dihe-in -124.05, 125.13 APE8-rot-in 284.23 APE67-dihe-in -62.44, -27.05 -45.7, -44.8 APE12-dist-in 7.899 APE11-dist-in 11.0492 APE10-dist-in 5.0684 APE9-dist-in 3.4557 None SEP177,SEP181 SEP177,SEP181 XRAY 2.83 0.186 0.236 B 677.0 649.0 3 27 24 3 [[15, 449]] 1.0 4kik Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.1e-50 180.0 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4E3CB O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.7231 12.4163 BLAminus -105.72, -155.63 -11.15, 130.65 -122.44, 23.83 259.84, 47.47 -53.22, -19.06 in-in in 8.4721 Saltbr-in 2.7706 HRD-in -75.6, -33.93 66.41, -70.8 in-in-out SNCiio in-out ActLoopNT-in 2.8748 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -41.33, 120.77 APE9-dihe-na 145.43, -135.28 APE8-dihe-in -71.19, 72.96 APE8-rot-in 313.16 APE67-dihe-out 41.01, -82.54 -50.74, -88.53 APE12-dist-in 8.1682 APE11-dist-out 7.7771 APE10-dist-out 11.4687 APE9-dist-out 12.7616 S177E,S181E None None XRAY 3.98 0.267 0.299 B 669.0 632.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4E3CC O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.7051 12.3482 BLAminus -106.09, -155.19 -11.21, 130.09 -121.05, 26.29 258.84, 49.2 -40.6, -84.85 in-in in 8.4622 Saltbr-in 2.7612 HRD-in -71.79, -36.13 68.15, -71.55 in-in-out SNCiio in-out ActLoopNT-in 2.6523 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -85.59, 121.05 APE9-dihe-na 114.45, 160.33 APE8-dihe-out -45.72, -30.46 APE8-rot-out 41.29 APE67-dihe-out -70.56, -0.85 47.27, 14.31 APE12-dist-in 8.1115 APE11-dist-in 10.92 APE10-dist-out 8.1558 APE9-dist-out 11.1496 S177E,S181E None None XRAY 3.98 0.267 0.299 C 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4E3CD O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.7967 12.4624 BLAminus -105.23, -154.26 -12.01, 129.89 -121.15, 31.39 257.96, 46.78 -48.12, -73.54 in-in in 8.4714 Saltbr-in 2.7476 HRD-in -71.85, -36.56 68.87, -68.74 in-in-out SNCiio in-out ActLoopNT-in 2.7073 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -114.45, 136.63 APE9-dihe-na 128.45, -179.44 APE8-dihe-in -65.09, 82.14 APE8-rot-in 325.06 APE67-dihe-in -46.95, -54.94 -65.9, -0.17 APE12-dist-out 6.6721 APE11-dist-in 10.406 APE10-dist-out 10.2423 APE9-dist-out 11.628 S177E,S181E None None XRAY 3.98 0.267 0.299 D 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4E3CF O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.6959 12.4712 BLAminus -105.36, -154.55 -11.85, 129.86 -122.15, 25.59 260.49, 46.17 -49.15, -47.61 in-in in 8.513 Saltbr-in 2.7733 HRD-in -73.41, -32.98 66.19, -71.94 in-in-out SNCiio in-out ActLoopNT-in 2.8623 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -67.61, 80.78 APE9-dihe-na 112.37, -167.24 APE8-dihe-in -59.27, 163.67 APE8-rot-in 314.68 APE67-dihe-in -41.53, -27.23 -138.25, 21.39 APE12-dist-in 9.3987 APE11-dist-in 9.604 APE10-dist-out 8.5263 APE9-dist-out 13.0124 S177E,S181E None None XRAY 3.98 0.267 0.299 F 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 8OMVC O14920 12 664 756.0 No_ligand No_ligand Inactive DFGin 8.0964 11.319 BLAminus -107.88, 165.55 59.11, 66.52 -75.63, 95.07 269.65, 121.32 -77.03, -67.33 in-out in 8.4903 Saltbr-out 6.4234 HRD-in -72.03, -37.96 70.51, -11.08 out-out-out SNCooo out-out ActLoopNT-out 4.0882 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnoo APE10-dihe-na 999.0, 160.41 APE9-dihe-na 157.46, -124.88 APE8-dihe-in -136.31, 148.05 APE8-rot-out 62.18 APE67-dihe-out -121.08, -66.51 -95.21, 70.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.9593 APE9-dist-out 9.5088 S177E,S181E None None XRAY 4.16 0.259 0.299 C 671.0 630.0 13 27 20 7 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 8OMVD O14920 6 665 756.0 No_ligand No_ligand Inactive DFGin 7.863 11.9364 BLAminus -105.3, 164.79 60.63, 66.88 -81.0, 63.33 264.63, 107.01 -73.78, -34.0 in-out in 9.2733 Saltbr-out 4.7503 HRD-in -72.17, -36.92 69.94, -10.55 out-out-out SNCooo out-out ActLoopNT-out 4.3343 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_niio APE10-dihe-na -141.13, 136.52 APE9-dihe-na 129.04, 163.75 APE8-dihe-in -138.59, 89.42 APE8-rot-out 174.05 APE67-dihe-out -100.49, -35.82 -139.2, 164.47 APE12-dist-none 999.0 APE11-dist-in 11.2914 APE10-dist-in 6.9096 APE9-dist-out 9.0653 S177E,S181E None None XRAY 4.16 0.259 0.299 D 671.0 638.0 12 27 19 8 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4KIKA O14920 9 663 756.0 KSA:60800 Type1 Inactive DFGin 6.178 12.724 BLAminus -127.36, 175.43 56.16, 79.78 -104.55, 41.64 323.18, 179.99 -47.28, 146.96 in-in in 8.4631 Saltbr-in 2.9853 HRD-in -64.56, -53.95 76.42, -28.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.34, -25.34 APE9-dihe-na -61.49, -48.74 APE8-dihe-out -60.84, -33.61 APE8-rot-out 70.5 APE67-dihe-in -55.1, -27.97 -77.97, -16.15 APE12-dist-out 22.3784 APE11-dist-out 21.1544 APE10-dist-out 23.5621 APE9-dist-out 12.5036 None SEP257 SEP257 XRAY 2.83 0.186 0.236 A 677.0 619.0 17 27 17 10 [[15, 449]] 1.0 4kik Homo sapiens OTHER_IKBKB_HUMAN OTHER 1.1e-50 180.0 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 8OMVB O14920 8 664 756.0 No_ligand No_ligand Inactive DFGin 7.6178 11.2823 BLBminus -108.54, 168.08 59.13, 68.65 -71.93, 172.37 306.75, 9.62 -115.69, -132.64 in-out in 9.6848 Saltbr-out 3.9373 HRD-in -72.28, -37.94 70.43, -9.98 out-out-out SNCooo out-out ActLoopNT-out 5.5919 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoo APE10-dihe-na 999.0, -5.22 APE9-dihe-na -138.83, -131.22 APE8-dihe-in -157.95, 113.56 APE8-rot-in 300.65 APE67-dihe-out -99.01, -1.05 179.64, 158.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.1428 APE9-dist-out 9.7628 S177E,S181E None None XRAY 4.16 0.259 0.299 B 671.0 641.0 16 27 18 9 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4E3CA O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9293 12.5145 None -102.89, -152.86 -13.03, 129.81 -123.22, 17.82 259.81, 46.81 -50.25, -6.57 in-in in 8.4978 Saltbr-in 2.7367 HRD-in -75.26, -33.92 66.88, -70.59 in-in-out SNCiio in-out ActLoopNT-in 2.667 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na 54.47, 176.72 APE9-dihe-na 61.59, 168.61 APE8-dihe-out -55.76, -20.8 APE8-rot-out 96.27 APE67-dihe-out -19.53, -58.21 71.19, -31.91 APE12-dist-in 7.8908 APE11-dist-in 11.3832 APE10-dist-out 9.7094 APE9-dist-out 11.5196 S177E,S181E None None XRAY 3.98 0.267 0.299 A 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 4E3CE O14920 16 665 756.0 No_ligand No_ligand Inactive DFGin 7.9501 12.2838 None -103.98, -153.14 -13.07, 129.81 -119.97, 29.25 259.42, 48.55 -39.7, -60.66 in-in in 8.4922 Saltbr-in 2.789 HRD-in -74.27, -34.04 66.66, -69.45 in-in-out SNCiio in-out ActLoopNT-in 2.7665 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -137.36, 34.73 APE9-dihe-na -147.47, 29.61 APE8-dihe-out 50.03, 13.62 APE8-rot-out 70.79 APE67-dihe-out 72.17, -45.62 58.67, -106.57 APE12-dist-in 7.8793 APE11-dist-in 9.547 APE10-dist-out 9.1157 APE9-dist-out 10.7947 S177E,S181E None None XRAY 3.98 0.267 0.299 E 669.0 624.0 4 27 27 0 [[15, 449]] 1.0 4e3c Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.4e-50 178.4 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 8OMVE O14920 9 643 756.0 No_ligand No_ligand Inactive DFGinter 7.5361 10.9015 None -105.5, 166.4 59.46, 69.27 -69.45, 93.59 281.39, 127.96 -78.86, -65.73 in-out in 9.1681 Saltbr-out 4.7128 HRD-in -72.45, -37.03 70.29, -11.28 out-out-out SNCooo out-out ActLoopNT-out 4.6819 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -157.14, 127.84 APE9-dihe-na -150.61, -127.8 APE8-dihe-out -138.47, -162.6 APE8-rot-out 59.63 APE67-dihe-in -96.12, -64.95 -135.66, 0.49 APE12-dist-in 9.5508 APE11-dist-in 11.2015 APE10-dist-in 7.7925 APE9-dist-out 7.8966 S177E,S181E None None XRAY 4.16 0.259 0.299 E 671.0 566.0 10 27 24 3 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
IKBKB IKKB_HUMAN 8OMVA O14920 8 666 756.0 No_ligand No_ligand Inactive None 999.0 999.0 None -106.7, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 9.6574 Saltbr-in 3.5262 HRD-in -71.9, -36.83 70.31, -11.77 in-out-out SNCioo out-out ActLoopNT-out 4.0623 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.13 APE8-dihe-out -137.8, 28.35 APE8-rot-in 324.42 APE67-dihe-in -67.65, -38.83 -135.68, -11.98 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0052 S177E,S181E None None XRAY 4.16 0.259 0.299 A 671.0 636.0 19 27 14 13 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.5e-50 178.5 1.0 249.0 249.0 165 166 167 169 171 44 61 65 142 144 143 145.0 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta

OTHER_IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name