AGC_GRK2 (Beta-adrenergic receptor kinase 1)

Total number of chains: 21
Active chains: 17
Uniprot: ARBK1_HUMAN
Kinase Domain Residues: 191 - 453
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 81.0% AF-P25098-K1A
DFGin None 4 19.0% 7PWDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P25098-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None Beta-adrenergic receptor kinase 1
AF-P25098-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None Beta-adrenergic receptor kinase 1
5UVCA 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8PV Type1 30 - 536 0 None None Beta-adrenergic receptor kinase 1
5UKLA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SIX Type1 31 - 671 0 None S670A Beta-adrenergic receptor kinase 1
5HE1A 3.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZS2 Type1 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1
6C2YA 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EJS Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1
4MK0A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 29X Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1
7K7LA 2.539 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W4D Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1
7K7ZA 2.606 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W4G Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1
3V5WA 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8PR Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1
4PNKA 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KZQ Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1
5WG3A 2.896 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AFM Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1
5WG4A 2.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AFV Type1 31 - 668 0 None None Beta-adrenergic receptor kinase 1
5WG5A 3.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZSO Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1
5UUUA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1.5_Front 31 - 538 0 None None Beta-adrenergic receptor kinase 1
5UKKA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DJ Type1.5_Front 30 - 667 0 None S670A Beta-adrenergic receptor kinase 1
6U7CA 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q1Y Type1.5_Front 30 - 669 0 None None Beta-adrenergic receptor kinase 1
3CIKA 2.75 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 669 0 None None Beta-adrenergic receptor kinase 1
7PWDA 2.6 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DS Type1 27 - 668 0 None S670A Beta-adrenergic receptor kinase 1
3KRWA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1
3KRXA 3.1 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1

AGC_GRK2 (Beta-adrenergic receptor kinase 1)

Total number of chains: 39
Active chains: 21
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 53.8% AF-P25098-K1A
DFGin None 14 35.9% 3PVUA
DFGin ABAminus 4 10.3% 8JPDG
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ARBK1_BOVIN 5HE0A 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 5HE2A 2.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F0S Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 5HE3A 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FF1 Type1 30 - 670 0 None None Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 5UKMA 3.03 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T0E Type1 31 - 669 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7B 4.5 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 8JPBG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 8JPCG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 8JPDG 2.81 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1OMWA 2.5 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7A 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7C 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7D 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 2BCJA 3.061 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 667 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3UZSA 4.52 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiio APEdist_iiii No_ligand No_ligand 29 - 671 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3UZTA 3.51 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 30 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3PSCA 2.67 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3PVUA 2.48 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3PVWA 2.49 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRX Type1 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_HUMAN AF-P25098-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN AF-P25098-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 183 - 461 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5UVCA 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8PV Type1 30 - 536 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5UKLA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SIX Type1 31 - 671 0 None S670A Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5HE1A 3.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZS2 Type1 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 6C2YA 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EJS Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 4MK0A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 29X Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 7K7LA 2.539 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W4D Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 7K7ZA 2.606 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W4G Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 3V5WA 2.07 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8PR Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 4PNKA 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KZQ Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5WG3A 2.896 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AFM Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5WG4A 2.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AFV Type1 31 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5WG5A 3.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZSO Type1 30 - 668 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5UUUA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1.5_Front 31 - 538 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 5UKKA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DJ Type1.5_Front 30 - 667 0 None S670A Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 6U7CA 2.44 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q1Y Type1.5_Front 30 - 669 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 3CIKA 2.75 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 669 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 7PWDA 2.6 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 8DS Type1 27 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 3KRWA 2.9 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens
ARBK1_HUMAN 3KRXA 3.1 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii BA1 Type1 30 - 671 0 None None Beta-adrenergic receptor kinase 1 Homo sapiens

AGC_GRK2 (Beta-adrenergic receptor kinase 1)

Total number of chains: 18
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 10 55.6% 3PVUA
DFGin ABAminus 4 22.2% 8JPDG
DFGin BLAminus 4 22.2% 5HE0A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ARBK1_BOVIN 5HE0A 2.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 453 Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 5HE2A 2.79 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii F0S Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 5HE3A 2.74 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FF1 Type1 30 - 670 0 None None Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 5UKMA 3.03 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii T0E Type1 31 - 669 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7B 4.5 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 8JPBG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 8JPCG 3.07 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 8JPDG 2.81 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 2 - 659 0 None A292P,R295I,S455D Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1OMWA 2.5 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7A 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7C 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 1YM7D 4.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 2BCJA 3.061 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 28 - 667 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3UZSA 4.52 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiio APEdist_iiii No_ligand No_ligand 29 - 671 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3UZTA 3.51 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 30 - 656 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3PSCA 2.67 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3PVUA 2.48 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRW Type1 30 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus
ARBK1_BOVIN 3PVWA 2.49 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii QRX Type1 29 - 668 0 None S670A Beta-adrenergic receptor kinase 1 Bos taurus