AGC_GRK2 (Beta-adrenergic receptor kinase 1)

Total number of chains: 21
Active chains: 17
Uniprot: ARBK1_HUMAN
Kinase Domain Residues: 191 - 453
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 17 81.0% AF-P25098-K1A
DFGin None 4 19.0% 7PWDA

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK2 AF-P25098-K1A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.5622 13.0673 BLAminus -119.78, 178.65 52.56, 73.94 -83.8, 16.08 278.33, 71.82 -60.8, -26.56 in-in in 8.5412 Saltbr-in 2.5893 HRD-in -80.89, -42.45 65.72, -2.62 in-in-in SNCiii in-in ActLoopNT-in 2.8867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.3, 128.35 APE9-dihe-na 142.96, -178.54 APE8-dihe-in -87.49, 128.15 APE8-rot-in 299.26 APE67-dihe-inflip 86.45, 0.9 -52.52, 136.47 APE12-dist-in 10.2338 APE11-dist-in 12.0254 APE10-dist-in 6.0827 APE9-dist-in 3.2902 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 26 26 0 [[191, 453]] 1.0 AF-P25098-K1 AGC_GRK2_HUMAN AGC 4.6e-78 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 AF-P25098-K3A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.32 12.8527 BLAminus -125.8, 178.57 52.64, 62.07 -71.89, 17.23 286.12, 88.29 -61.97, -25.79 in-in in 8.526 Saltbr-in 2.5505 HRD-in -86.05, -43.82 69.06, 3.02 in-in-in SNCiii in-in ActLoopNT-in 2.8478 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.98, 153.8 APE9-dihe-na 127.94, -163.33 APE8-dihe-in -103.05, 123.69 APE8-rot-in 298.01 APE67-dihe-inflip 89.53, 2.54 -53.74, 129.56 APE12-dist-in 9.0608 APE11-dist-in 11.855 APE10-dist-in 5.9514 APE9-dist-in 3.215 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 26 26 0 [[191, 453]] 1.0 AF-P25098-K3 AGC_GRK2_HUMAN AGC 4.6e-78 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5UVCA P25098 30 536 689.0 8PV:600 Type1 Active DFGin 5.6459 13.252 BLAminus -111.93, -175.1 48.95, 84.95 -96.99, 16.3 272.95, 81.76 -56.56, -35.65 in-in in 8.6666 Saltbr-in 2.7965 HRD-in -90.5, -43.84 74.99, -18.44 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.43, 134.46 APE9-dihe-na 148.93, -160.88 APE8-dihe-in -114.94, 135.94 APE8-rot-in 305.71 APE67-dihe-in -77.66, 1.58 -57.71, -38.48 APE12-dist-in 10.2466 APE11-dist-in 12.0267 APE10-dist-in 6.1071 APE9-dist-in 3.357 None None None XRAY 2.65 0.217 0.26 A 547.0 457.0 0 26 26 0 [[191, 453]] 1.0 5uvc AGC_GRK2_HUMAN AGC 3.7e-77 268.3 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5UKLA P25098 31 671 689.0 SIX:702 Type1 Active DFGin 5.5525 13.4547 BLAminus -136.15, 162.37 65.35, 90.8 -91.1, 16.16 287.26, 80.35 -44.51, -43.27 in-in in 8.9358 Saltbr-in 2.6266 HRD-in -76.69, -51.69 80.53, -28.69 in-in-in SNCiii in-in ActLoopNT-in 2.9516 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.59, 119.44 APE9-dihe-na 167.03, -154.05 APE8-dihe-in -112.97, 140.97 APE8-rot-in 300.02 APE67-dihe-in -82.52, 9.1 -61.65, -35.94 APE12-dist-in 10.2011 APE11-dist-in 11.7419 APE10-dist-in 5.8434 APE9-dist-in 3.7561 S670A None None XRAY 2.15 0.184 0.228 A 642.0 630.0 0 26 26 0 [[191, 453]] 1.0 5ukl AGC_GRK2_HUMAN AGC 5.4e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5HE1A P25098 29 668 689.0 ZS2:701 Type1 Active DFGin 5.7607 13.0739 BLAminus -136.45, 161.18 63.18, 92.12 -104.97, 24.32 295.58, 61.08 -54.15, -39.68 in-in in 8.6303 Saltbr-in 2.9645 HRD-in -75.81, -60.39 89.65, -39.71 in-in-in SNCiii in-in ActLoopNT-in 2.9796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.97, 100.73 APE9-dihe-na -165.78, -165.71 APE8-dihe-in -91.06, 127.63 APE8-rot-in 294.03 APE67-dihe-inflip 109.39, -17.56 -55.26, 129.29 APE12-dist-in 10.3336 APE11-dist-in 12.1323 APE10-dist-in 6.3113 APE9-dist-in 3.8934 S670A None None XRAY 3.15 0.172 0.25 A 642.0 618.0 0 26 26 0 [[191, 453]] 1.0 5he1 AGC_GRK2_HUMAN AGC 5.4e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 6C2YA P25098 30 668 689.0 EJS:701 Type1 Active DFGin 5.2477 13.1313 BLAminus -133.84, 169.51 63.67, 85.91 -91.46, 28.99 286.98, 69.09 -62.06, -46.79 in-in in 8.7773 Saltbr-in 2.6025 HRD-in -71.8, -47.67 74.94, -21.53 in-in-in SNCiii in-in ActLoopNT-in 3.2292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.32, 147.42 APE9-dihe-na 138.79, -162.57 APE8-dihe-in -110.7, 130.32 APE8-rot-in 292.69 APE67-dihe-inflip 102.38, -19.78 -58.44, 136.12 APE12-dist-in 9.5744 APE11-dist-in 11.9534 APE10-dist-in 5.9756 APE9-dist-in 3.4531 S670A None None XRAY 2.74 0.247 0.292 A 689.0 617.0 2 26 26 0 [[191, 453]] 1.0 6c2y AGC_GRK2_HUMAN AGC 6.3e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 4MK0A P25098 30 668 689.0 29X:60702 Type1 Active DFGin 5.0222 12.5575 BLAminus -114.3, 159.32 62.47, 95.12 -99.09, 26.84 314.83, 15.76 -55.23, -46.17 in-in in 8.7964 Saltbr-in 3.2929 HRD-in -74.82, -46.73 65.86, 15.22 in-in-in SNCiii in-in ActLoopNT-in 2.8054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.22, 138.8 APE9-dihe-na 140.75, -169.47 APE8-dihe-in -90.2, 139.3 APE8-rot-in 300.61 APE67-dihe-inflip 101.57, -12.83 -69.61, 140.12 APE12-dist-in 10.2148 APE11-dist-in 12.1548 APE10-dist-in 6.4186 APE9-dist-in 3.2251 None None None XRAY 2.4 0.179 0.238 A 640.0 630.0 0 26 26 0 [[191, 453]] 1.0 4mk0 AGC_GRK2_HUMAN AGC 5.3e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 7K7LA P25098 30 668 689.0 W4D:702 Type1 Active DFGin 5.3464 13.407 BLAminus -120.75, 157.11 65.86, 85.74 -89.44, 20.76 269.03, 169.7 -63.22, -26.35 in-in in 9.0879 Saltbr-in 2.7438 HRD-in -83.14, -50.8 72.46, -22.33 in-in-in SNCiii in-in ActLoopNT-in 2.8171 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.43, 143.89 APE9-dihe-na 130.34, -178.78 APE8-dihe-in -87.05, 140.86 APE8-rot-in 300.91 APE67-dihe-inflip 101.09, -17.29 -67.82, 137.73 APE12-dist-in 10.8032 APE11-dist-in 12.386 APE10-dist-in 6.4429 APE9-dist-in 3.6669 None None None XRAY 2.539 0.203 0.244 A 640.0 616.0 0 26 26 0 [[191, 453]] 1.0 7k7l AGC_GRK2_HUMAN AGC 5.3e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 7K7ZA P25098 30 668 689.0 W4G:701 Type1 Active DFGin 5.2276 13.2609 BLAminus -131.21, 159.45 58.45, 84.74 -81.51, 17.96 273.45, 160.93 -49.98, -46.53 in-in in 9.1503 Saltbr-in 2.6057 HRD-in -69.84, -65.83 82.28, 6.02 in-in-in SNCiii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 129.42 APE9-dihe-na 151.42, -156.98 APE8-dihe-in -108.77, 134.07 APE8-rot-in 292.67 APE67-dihe-inflip 104.4, -17.1 -64.98, 131.58 APE12-dist-in 12.6858 APE11-dist-in 12.3085 APE10-dist-in 6.4852 APE9-dist-in 3.2799 None None None XRAY 2.606 0.207 0.262 A 640.0 625.0 0 26 26 0 [[191, 453]] 1.0 7k7z AGC_GRK2_HUMAN AGC 5.3e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 3V5WA P25098 30 668 689.0 8PR:701 Type1 Active DFGin 5.1567 12.9917 BLAminus -135.73, 166.74 63.47, 84.47 -90.01, 8.76 284.89, 155.02 -55.83, -32.04 in-in in 8.9278 Saltbr-in 2.9291 HRD-in -75.87, -48.67 77.13, -26.65 in-in-in SNCiii in-in ActLoopNT-in 2.9163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 132.09 APE9-dihe-na 148.62, -167.37 APE8-dihe-in -102.18, 145.22 APE8-rot-in 303.37 APE67-dihe-in -68.83, -4.06 -70.22, -32.86 APE12-dist-in 10.0001 APE11-dist-in 11.8614 APE10-dist-in 5.9102 APE9-dist-in 3.6888 None None None XRAY 2.07 0.196 0.247 A 689.0 623.0 0 26 26 0 [[191, 453]] 1.0 3v5w AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 4PNKA P25098 30 668 689.0 KZQ:701 Type1 Active DFGin 5.6956 13.3098 BLAminus -131.92, 150.67 73.23, 94.18 -104.4, 20.24 276.38, 72.07 -49.27, -48.99 in-in in 8.8686 Saltbr-in 2.8918 HRD-in -75.55, -46.99 79.65, -28.55 in-in-in SNCiii in-in ActLoopNT-in 3.0292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.99, 151.18 APE9-dihe-na 153.42, -170.47 APE8-dihe-in -97.49, 139.43 APE8-rot-in 296.18 APE67-dihe-inflip 99.83, -0.25 -68.24, 133.65 APE12-dist-in 10.1099 APE11-dist-in 11.7313 APE10-dist-in 5.9401 APE9-dist-in 3.5973 None None None XRAY 2.56 0.194 0.259 A 689.0 625.0 0 26 26 0 [[191, 453]] 1.0 4pnk AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5WG3A P25098 30 668 689.0 AFM:701 Type1 Active DFGin 5.2508 12.6657 BLAminus -140.32, 170.95 56.45, 82.96 -87.3, 21.74 311.79, 174.31 -59.6, -38.71 in-in in 8.9483 Saltbr-in 2.8469 HRD-in -82.02, -43.09 42.08, 25.46 in-in-in SNCiii in-in ActLoopNT-in 3.2573 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.78, 131.07 APE9-dihe-na 153.01, -166.14 APE8-dihe-in -107.02, 132.83 APE8-rot-in 302.54 APE67-dihe-inflip 106.87, -20.46 -62.02, 131.15 APE12-dist-in 10.4276 APE11-dist-in 11.7933 APE10-dist-in 5.9015 APE9-dist-in 3.3586 None None None XRAY 2.896 0.201 0.248 A 689.0 618.0 5 26 26 0 [[191, 453]] 1.0 5wg3 AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5WG4A P25098 31 668 689.0 AFV:701 Type1 Active DFGin 5.3057 12.6907 BLAminus -133.5, 178.66 54.05, 81.87 -91.99, 21.58 286.03, 73.35 -64.61, -41.57 in-in in 8.5477 Saltbr-in 3.1343 HRD-in -85.74, -45.07 68.56, -11.01 in-in-in SNCiii in-in ActLoopNT-in 3.1518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 129.47 APE9-dihe-na 146.73, -166.55 APE8-dihe-in -108.67, 131.04 APE8-rot-in 299.39 APE67-dihe-inflip 106.48, -11.49 -60.32, 128.85 APE12-dist-in 10.344 APE11-dist-in 11.9796 APE10-dist-in 6.1426 APE9-dist-in 3.4618 None None None XRAY 2.31 0.235 0.279 A 689.0 621.0 2 26 26 0 [[191, 453]] 1.0 5wg4 AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5WG5A P25098 30 668 689.0 ZSO:701 Type1 Active DFGin 5.4509 13.0103 BLAminus -128.14, 171.88 56.74, 83.28 -91.88, 32.75 279.7, 68.89 -65.05, -47.67 in-in in 8.625 Saltbr-in 2.6505 HRD-in -77.29, -47.13 67.77, -1.76 in-in-in SNCiii in-in ActLoopNT-in 2.9921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.64, 131.79 APE9-dihe-na 147.8, -171.59 APE8-dihe-in -95.05, 124.52 APE8-rot-in 297.6 APE67-dihe-inflip 97.31, -8.85 -62.05, 143.11 APE12-dist-in 10.4905 APE11-dist-in 12.0444 APE10-dist-in 6.1933 APE9-dist-in 3.3918 None None None XRAY 3.1 0.19 0.232 A 689.0 617.0 3 26 26 0 [[191, 453]] 1.0 5wg5 AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5UUUA P25098 31 538 689.0 QRW:601 Type1.5_Front Active DFGin 5.4075 13.1234 BLAminus -119.49, 148.71 76.08, 97.29 -99.15, 18.56 280.12, 88.0 -55.68, -33.52 in-in in 8.3995 Saltbr-in 2.9715 HRD-in -81.09, -44.67 78.9, -27.11 in-in-in SNCiii in-in ActLoopNT-in 3.1511 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.83, 137.94 APE9-dihe-na 132.21, -156.97 APE8-dihe-in -118.83, 132.35 APE8-rot-in 311.27 APE67-dihe-inflip 94.82, -15.58 -63.39, 132.05 APE12-dist-in 9.9224 APE11-dist-in 11.8901 APE10-dist-in 5.9307 APE9-dist-in 3.5492 None None None XRAY 2.7 0.215 0.257 A 547.0 414.0 0 26 26 0 [[191, 453]] 1.0 5uuu AGC_GRK2_HUMAN AGC 3.7e-77 268.3 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 5UKKA P25098 30 667 689.0 8DJ:702 Type1.5_Front Active DFGin 5.4401 12.8485 BLAminus -148.52, 179.61 57.76, 73.54 -87.98, 8.97 274.06, 69.08 -60.04, -18.89 in-in in 8.2709 Saltbr-in 2.6689 HRD-in -76.24, -37.94 75.49, -51.75 in-in-in SNCiii in-in ActLoopNT-in 2.9425 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.39, 145.94 APE9-dihe-na 143.2, -151.45 APE8-dihe-in -131.14, 141.32 APE8-rot-in 299.97 APE67-dihe-in -67.12, -33.98 -48.24, -30.82 APE12-dist-in 9.6352 APE11-dist-in 11.8188 APE10-dist-in 5.8456 APE9-dist-in 4.1568 S670A None None XRAY 2.6 0.224 0.281 A 642.0 613.0 0 26 26 0 [[191, 453]] 1.0 5ukk AGC_GRK2_HUMAN AGC 5.4e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 6U7CA P25098 30 669 689.0 Q1Y:701 Type1.5_Front Active DFGin 5.0615 12.4543 BLAminus -136.54, 170.55 57.52, 81.77 -86.77, 20.22 308.16, 7.53 -58.1, -34.47 in-in in 9.0498 Saltbr-in 2.5429 HRD-in -72.35, -46.72 70.07, -13.25 in-in-in SNCiii in-in ActLoopNT-in 3.3699 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 132.95 APE9-dihe-na 147.35, -168.5 APE8-dihe-in -105.63, 128.22 APE8-rot-in 297.44 APE67-dihe-inflip 124.86, -14.55 -55.92, 113.23 APE12-dist-in 10.2056 APE11-dist-in 12.016 APE10-dist-in 6.0719 APE9-dist-in 3.4845 None None None XRAY 2.44 0.237 0.262 A 689.0 631.0 0 26 26 0 [[191, 453]] 1.0 6u7c AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 3CIKA P25098 29 669 689.0 No_ligand No_ligand Inactive DFGin 5.2003 12.94 None -113.38, -84.39 -77.41, 106.5 -85.28, 5.55 272.59, 132.44 -54.41, -34.31 in-in in 8.589 Saltbr-in 2.8304 HRD-in -65.15, -43.87 69.81, -16.37 in-in-in SNCiii in-in ActLoopNT-in 2.8246 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.98, 126.35 APE9-dihe-na 141.75, -159.25 APE8-dihe-in -111.86, 146.5 APE8-rot-in 310.14 APE67-dihe-in -81.13, 3.2 -68.81, -30.14 APE12-dist-in 10.9775 APE11-dist-in 12.0726 APE10-dist-in 6.4171 APE9-dist-in 3.5873 None None None XRAY 2.75 0.208 0.269 A 689.0 619.0 0 26 26 0 [[191, 453]] 1.0 3cik AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 7PWDA P25098 27 668 689.0 8DS:701 Type1 Inactive DFGin 5.2813 12.9593 None -103.27, -91.53 -83.38, 120.45 -98.95, 11.01 295.2, 164.91 -62.17, -28.84 in-in in 8.7988 Saltbr-in 2.8227 HRD-in -68.27, -51.69 76.81, -22.19 in-in-in SNCiii in-in ActLoopNT-in 2.8256 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.66, 145.62 APE9-dihe-na 123.25, -162.48 APE8-dihe-in -110.04, 138.42 APE8-rot-in 305.66 APE67-dihe-inflip 98.02, -22.76 -65.28, 137.62 APE12-dist-in 10.312 APE11-dist-in 11.9263 APE10-dist-in 6.0194 APE9-dist-in 3.3652 S670A None None XRAY 2.6 0.192 0.23 A 697.0 621.0 0 26 26 0 [[191, 453]] 1.0 7pwd AGC_GRK2_HUMAN AGC 6.4e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 3KRWA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4431 12.512 None -124.43, -69.99 -70.72, 103.06 -103.15, 18.82 281.61, 154.56 -63.74, -46.79 in-in in 8.9073 Saltbr-in 2.6208 HRD-in -80.35, -50.37 71.38, -3.06 in-in-in SNCiii in-in ActLoopNT-in 2.7506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.68, 135.05 APE9-dihe-na 136.51, -178.33 APE8-dihe-in -97.44, 143.34 APE8-rot-in 311.93 APE67-dihe-in -81.84, -17.98 -65.75, -16.48 APE12-dist-in 9.7737 APE11-dist-in 11.7182 APE10-dist-in 5.7635 APE9-dist-in 3.2649 None None None XRAY 2.9 0.216 0.265 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krw AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 3KRXA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4192 12.8449 None -125.39, -77.94 -69.67, 105.65 -105.64, 33.0 281.38, 161.16 -76.22, -41.07 in-in in 9.1809 Saltbr-in 2.9453 HRD-in -81.43, -47.09 70.32, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.75, 134.45 APE9-dihe-na 144.08, -171.31 APE8-dihe-in -102.11, 138.21 APE8-rot-in 300.04 APE67-dihe-in -91.64, -15.37 -61.65, -13.24 APE12-dist-in 9.2638 APE11-dist-in 11.5714 APE10-dist-in 5.62 APE9-dist-in 3.2776 None None None XRAY 3.1 0.232 0.27 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krx AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1

AGC_GRK2 (Beta-adrenergic receptor kinase 1)

Total number of chains: 39
Active chains: 21
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 21 53.8% AF-P25098-K1A
DFGin None 14 35.9% 3PVUA
DFGin ABAminus 4 10.3% 8JPDG

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK2 ARBK1_BOVIN 5HE0A P21146 30 668 689.0 453:701 Type1 Active DFGin 5.2592 13.1171 BLAminus -137.72, 161.16 67.72, 86.34 -84.98, 14.88 287.85, 80.12 -42.13, -60.12 in-in in 8.4671 Saltbr-in 2.8678 HRD-in -68.65, -49.34 77.87, -29.18 in-in-in SNCiii in-in ActLoopNT-in 2.8588 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.25, 120.14 APE9-dihe-na 171.2, -142.82 APE8-dihe-in -122.87, 132.42 APE8-rot-in 285.63 APE67-dihe-inflip 113.92, -33.46 -57.37, 128.9 APE12-dist-in 10.1735 APE11-dist-in 11.7707 APE10-dist-in 5.8798 APE9-dist-in 3.5488 S670A None None XRAY 2.56 0.205 0.264 A 641.0 621.0 0 26 26 0 [[191, 453]] 1.0 5he0 Bos taurus AGC_GRK2_BOVIN AGC 5.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 5HE2A P21146 30 668 689.0 F0S:701 Type1 Active DFGin 5.2664 13.4322 BLAminus -127.84, 162.02 76.97, 74.62 -82.13, 19.63 285.89, 54.35 -44.91, -55.91 in-in in 8.6986 Saltbr-in 2.6713 HRD-in -87.07, -48.72 79.5, -27.96 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.3, 135.41 APE9-dihe-na 128.88, -173.45 APE8-dihe-in -85.86, 172.32 APE8-rot-in 301.72 APE67-dihe-in -88.54, 16.07 -85.52, -45.68 APE12-dist-in 10.698 APE11-dist-in 11.9311 APE10-dist-in 5.9928 APE9-dist-in 3.7816 S670A None None XRAY 2.79 0.202 0.277 A 641.0 628.0 0 26 26 0 [[191, 453]] 1.0 5he2 Bos taurus AGC_GRK2_BOVIN AGC 5.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 5HE3A P21146 30 670 689.0 FF1:702 Type1 Active DFGin 5.4706 13.1124 BLAminus -130.61, 154.77 82.75, 74.09 -80.19, 15.36 283.76, 73.33 -31.6, -75.24 in-in in 8.613 Saltbr-in 2.7525 HRD-in -66.32, -31.89 63.86, -19.84 in-in-in SNCiii in-in ActLoopNT-in 2.9166 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.68, 142.9 APE9-dihe-na 127.74, 174.69 APE8-dihe-in -90.13, 145.29 APE8-rot-in 301.32 APE67-dihe-inflip 112.74, -14.85 -68.46, 126.13 APE12-dist-in 10.205 APE11-dist-in 11.7078 APE10-dist-in 5.915 APE9-dist-in 3.371 None None None XRAY 2.74 0.198 0.257 A 641.0 623.0 0 26 26 0 [[191, 453]] 1.0 5he3 Bos taurus AGC_GRK2_BOVIN AGC 5.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 5UKMA P21146 31 669 689.0 T0E:701 Type1 Active DFGin 5.5585 13.1317 BLAminus -130.36, 150.32 61.48, 90.2 -96.51, 21.64 296.35, 62.89 -55.13, -59.92 in-in in 9.0172 Saltbr-in 2.7861 HRD-in -71.89, -48.96 73.51, -73.8 in-in-in SNCiii in-in ActLoopNT-in 3.1669 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.94, 135.34 APE9-dihe-na 121.47, 173.74 APE8-dihe-in -77.03, 143.73 APE8-rot-in 316.68 APE67-dihe-in -68.91, -23.51 -68.56, -33.79 APE12-dist-in 10.3025 APE11-dist-in 11.6096 APE10-dist-in 5.8336 APE9-dist-in 5.3132 S670A None None XRAY 3.03 0.2 0.252 A 695.0 621.0 0 26 26 0 [[191, 453]] 1.0 5ukm Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7B P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.1989 12.4485 ABAminus -130.8, -59.92 -98.26, 108.63 -91.58, -9.04 306.19, 95.69 -36.4, -48.74 in-out in 8.8033 Saltbr-out 4.6419 HRD-in -77.09, -44.3 73.62, -27.39 out-in-in SNCoii in-in ActLoopNT-in 2.7591 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.17, 125.32 APE9-dihe-na 152.82, 174.56 APE8-dihe-in -87.32, 142.62 APE8-rot-in 313.75 APE67-dihe-in -64.86, -36.54 -62.56, -29.46 APE12-dist-in 9.8182 APE11-dist-in 11.5603 APE10-dist-in 5.5731 APE9-dist-in 4.0361 S670A None None XRAY 4.5 0.226 0.279 B 689.0 608.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 8JPBG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.5082 12.2136 ABAminus -113.28, -56.44 -93.74, 100.06 -93.25, 26.0 307.53, 3.55 -63.32, -43.2 in-out in 8.9334 Saltbr-out 4.2174 HRD-out -93.17, 87.64 -73.74, -9.71 out-in-in SNCoii in-in ActLoopNT-in 2.7258 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.15, 142.89 APE9-dihe-na 142.59, -152.8 APE8-dihe-in -124.3, 137.48 APE8-rot-in 299.05 APE67-dihe-inflip 90.41, -8.27 -58.8, 137.88 APE12-dist-in 9.9025 APE11-dist-in 12.0099 APE10-dist-in 6.0986 APE9-dist-in 3.6298 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpb Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 8JPCG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.1571 ABAminus -113.22, -56.58 -93.6, 101.44 -93.44, 27.48 306.81, 9.79 -63.79, -45.14 in-out in 8.9895 Saltbr-out 4.6535 HRD-out -92.62, 94.67 -75.66, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6526 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.27, 130.92 APE9-dihe-na 162.84, -151.71 APE8-dihe-in -129.7, 130.81 APE8-rot-in 302.62 APE67-dihe-inflip 97.48, -17.5 -57.09, 134.46 APE12-dist-in 9.7132 APE11-dist-in 11.9892 APE10-dist-in 5.9887 APE9-dist-in 4.3163 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpc Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 8JPDG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.3847 12.1571 ABAminus -113.24, -56.55 -93.57, 101.39 -93.42, 27.53 306.84, 9.79 -63.78, -45.12 in-out in 8.9895 Saltbr-out 4.6534 HRD-out -92.61, 94.65 -75.65, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.32, 130.92 APE9-dihe-na 162.83, -151.7 APE8-dihe-in -129.72, 130.82 APE8-rot-in 302.58 APE67-dihe-inflip 97.48, -17.49 -57.11, 134.43 APE12-dist-in 9.7137 APE11-dist-in 11.9887 APE10-dist-in 5.9885 APE9-dist-in 4.3171 A292P,R295I,S455D None None EM 2.81 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpd Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1OMWA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.448 13.0685 None -112.27, -91.9 -67.18, 126.78 -99.0, 7.24 286.96, 109.41 -44.09, -46.49 in-in in 8.9372 Saltbr-in 3.4107 HRD-in -73.22, -52.41 80.02, -28.79 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.71, 128.56 APE9-dihe-na 124.77, -168.54 APE8-dihe-in -89.28, 150.91 APE8-rot-in 295.71 APE67-dihe-in -77.59, -9.92 -72.81, -27.02 APE12-dist-in 10.5885 APE11-dist-in 11.8774 APE10-dist-in 6.1942 APE9-dist-in 3.5029 S670A None None XRAY 2.5 0.216 0.252 A 689.0 614.0 0 26 26 0 [[191, 453]] 1.0 1omw Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7A P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2239 12.3565 None -125.66, -66.29 -94.21, 107.11 -86.73, -10.11 307.87, 97.53 -38.26, -47.46 in-out in 8.8531 Saltbr-out 4.6372 HRD-in -74.94, -45.18 74.24, -26.22 out-in-in SNCoii in-in ActLoopNT-in 2.7715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 123.21 APE9-dihe-na 155.55, 174.57 APE8-dihe-in -86.11, 141.22 APE8-rot-in 314.43 APE67-dihe-in -66.31, -34.76 -64.21, -27.3 APE12-dist-in 9.8313 APE11-dist-in 11.5432 APE10-dist-in 5.5926 APE9-dist-in 3.9926 S670A None None XRAY 4.5 0.226 0.279 A 689.0 608.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7C P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2163 12.2674 None -130.34, -66.38 -92.79, 106.85 -85.97, -13.2 309.12, 95.06 -35.96, -48.47 in-out in 8.8136 Saltbr-out 4.7358 HRD-in -75.86, -48.89 75.97, -29.41 out-in-in SNCoii in-in ActLoopNT-in 2.721 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.29, 128.8 APE9-dihe-na 145.96, 173.8 APE8-dihe-in -87.44, 141.12 APE8-rot-in 314.72 APE67-dihe-in -67.09, -36.43 -60.22, -25.52 APE12-dist-in 9.7747 APE11-dist-in 11.5691 APE10-dist-in 5.6074 APE9-dist-in 4.0582 S670A None None XRAY 4.5 0.226 0.279 C 689.0 607.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7D P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2341 12.3436 None -128.88, -67.33 -92.65, 105.41 -87.88, -10.71 307.83, 96.53 -37.49, -49.46 in-out in 8.801 Saltbr-out 4.7459 HRD-in -72.13, -45.13 72.62, -27.86 out-in-in SNCoii in-in ActLoopNT-in 2.7633 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.27, 125.22 APE9-dihe-na 149.39, 173.11 APE8-dihe-in -84.5, 141.69 APE8-rot-in 315.18 APE67-dihe-in -66.11, -35.98 -62.26, -27.83 APE12-dist-in 9.7362 APE11-dist-in 11.4974 APE10-dist-in 5.5333 APE9-dist-in 4.0286 S670A None None XRAY 4.5 0.226 0.279 D 689.0 599.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 2BCJA P21146 28 667 689.0 No_ligand No_ligand Inactive DFGin 5.1531 12.3754 None -114.23, -125.71 -23.26, 91.28 -81.33, 0.62 275.63, 158.44 -51.51, -42.54 in-in in 8.6198 Saltbr-in 2.6334 HRD-in -86.19, -45.87 70.94, -23.92 in-in-in SNCiii in-in ActLoopNT-in 2.7186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 137.19 APE9-dihe-na 118.03, -177.98 APE8-dihe-in -75.0, 121.63 APE8-rot-in 302.92 APE67-dihe-in -97.57, -19.7 -76.89, 19.37 APE12-dist-in 11.0395 APE11-dist-in 11.9406 APE10-dist-in 6.0057 APE9-dist-in 3.715 S670A None None XRAY 3.061 0.236 0.292 A 689.0 624.0 0 26 26 0 [[191, 453]] 1.0 2bcj Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3UZSA P21146 29 671 689.0 No_ligand No_ligand Inactive DFGin 5.731 11.1485 None -107.21, -110.21 -68.72, 97.64 -52.38, -56.06 299.08, 3.09 42.56, -75.63 in-out in 9.0047 Saltbr-out 3.9207 HRD-in -77.33, -41.02 60.69, 32.77 out-in-out SNCoio in-out ActLoopNT-in 3.5286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -98.18, 142.14 APE9-dihe-na 139.16, 169.96 APE8-dihe-in -74.03, 124.78 APE8-rot-in 315.02 APE67-dihe-out 166.07, -43.85 -59.08, 78.84 APE12-dist-in 10.2386 APE11-dist-in 12.0969 APE10-dist-in 6.31 APE9-dist-in 3.5138 S670A None None XRAY 4.52 0.188 0.268 A 689.0 609.0 20 26 26 0 [[191, 453]] 1.0 3uzs Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3UZTA P21146 30 656 689.0 No_ligand No_ligand Inactive DFGin 5.216 12.499 None -94.28, -95.77 -83.37, 90.84 -54.75, -37.85 271.69, 47.64 -2.65, -69.38 in-out in 8.8257 Saltbr-out 5.0807 HRD-in -72.79, -37.98 67.02, -27.54 out-in-in SNCoii in-in ActLoopNT-in 3.085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.51, 148.65 APE9-dihe-na 138.76, 168.6 APE8-dihe-in -71.39, 126.55 APE8-rot-in 294.92 APE67-dihe-in -71.95, -17.71 -54.34, -25.29 APE12-dist-in 9.5328 APE11-dist-in 12.0098 APE10-dist-in 5.9885 APE9-dist-in 3.8685 S670A None None XRAY 3.51 0.22 0.317 A 689.0 586.0 12 26 26 0 [[191, 453]] 1.0 3uzt Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3PSCA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.4842 12.8251 None -112.1, -116.4 -50.02, 128.26 -100.71, 13.15 287.53, 88.47 -45.02, -46.74 in-in in 8.8883 Saltbr-in 3.1136 HRD-in -73.4, -47.49 67.75, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.59, 142.02 APE9-dihe-na 121.44, 174.37 APE8-dihe-in -79.3, 138.73 APE8-rot-in 323.05 APE67-dihe-in -80.94, 3.9 -61.06, -31.71 APE12-dist-in 10.1172 APE11-dist-in 11.7629 APE10-dist-in 5.9289 APE9-dist-in 3.1916 S670A None None XRAY 2.67 0.225 0.257 A 695.0 614.0 0 26 26 0 [[191, 453]] 1.0 3psc Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3PVUA P21146 30 668 689.0 QRW:800 Type1 Inactive DFGin 5.4293 12.5496 None -114.2, -126.97 -29.78, 116.79 -95.83, 7.38 283.37, 161.7 -55.56, -22.85 in-in in 8.7486 Saltbr-in 2.9863 HRD-in -71.34, -46.23 80.59, -11.92 in-in-in SNCiii in-in ActLoopNT-in 2.9271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.26, 142.91 APE9-dihe-na 117.3, -165.9 APE8-dihe-in -102.62, 148.45 APE8-rot-in 314.0 APE67-dihe-in -77.54, 11.33 -67.23, -35.08 APE12-dist-in 10.2837 APE11-dist-in 11.8902 APE10-dist-in 6.1863 APE9-dist-in 3.4202 S670A None None XRAY 2.48 0.229 0.274 A 695.0 609.0 0 26 26 0 [[191, 453]] 1.0 3pvu Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3PVWA P21146 29 668 689.0 QRX:800 Type1 Inactive DFGin 5.249 12.3972 None -104.93, -94.33 -60.0, 121.61 -95.37, 6.96 285.31, 4.38 -65.85, -19.47 in-in in 8.7495 Saltbr-in 3.07 HRD-in -69.01, -52.71 78.6, -13.88 in-in-in SNCiii in-in ActLoopNT-in 2.9188 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.25, 142.6 APE9-dihe-na 127.77, 176.65 APE8-dihe-in -84.9, 148.79 APE8-rot-in 327.3 APE67-dihe-in -77.16, 13.46 -65.86, -42.83 APE12-dist-in 10.7375 APE11-dist-in 12.1865 APE10-dist-in 6.4122 APE9-dist-in 3.337 S670A None None XRAY 2.49 0.239 0.285 A 695.0 613.0 0 26 26 0 [[191, 453]] 1.0 3pvw Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN AF-P25098-K1A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.5622 13.0673 BLAminus -119.78, 178.65 52.56, 73.94 -83.8, 16.08 278.33, 71.82 -60.8, -26.56 in-in in 8.5412 Saltbr-in 2.5893 HRD-in -80.89, -42.45 65.72, -2.62 in-in-in SNCiii in-in ActLoopNT-in 2.8867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.3, 128.35 APE9-dihe-na 142.96, -178.54 APE8-dihe-in -87.49, 128.15 APE8-rot-in 299.26 APE67-dihe-inflip 86.45, 0.9 -52.52, 136.47 APE12-dist-in 10.2338 APE11-dist-in 12.0254 APE10-dist-in 6.0827 APE9-dist-in 3.2902 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 26 26 0 [[191, 453]] 1.0 AF-P25098-K1 Homo sapiens AGC_GRK2_HUMAN AGC 4.6e-78 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN AF-P25098-K3A P25098 183 461 689.0 No_ligand No_ligand Active DFGin 5.32 12.8527 BLAminus -125.8, 178.57 52.64, 62.07 -71.89, 17.23 286.12, 88.29 -61.97, -25.79 in-in in 8.526 Saltbr-in 2.5505 HRD-in -86.05, -43.82 69.06, 3.02 in-in-in SNCiii in-in ActLoopNT-in 2.8478 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.98, 153.8 APE9-dihe-na 127.94, -163.33 APE8-dihe-in -103.05, 123.69 APE8-rot-in 298.01 APE67-dihe-inflip 89.53, 2.54 -53.74, 129.56 APE12-dist-in 9.0608 APE11-dist-in 11.855 APE10-dist-in 5.9514 APE9-dist-in 3.215 None None None AF2 -1.0 1.0 1.0 A 279.0 279.0 0 26 26 0 [[191, 453]] 1.0 AF-P25098-K3 Homo sapiens AGC_GRK2_HUMAN AGC 4.6e-78 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5UVCA P25098 30 536 689.0 8PV:600 Type1 Active DFGin 5.6459 13.252 BLAminus -111.93, -175.1 48.95, 84.95 -96.99, 16.3 272.95, 81.76 -56.56, -35.65 in-in in 8.6666 Saltbr-in 2.7965 HRD-in -90.5, -43.84 74.99, -18.44 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.43, 134.46 APE9-dihe-na 148.93, -160.88 APE8-dihe-in -114.94, 135.94 APE8-rot-in 305.71 APE67-dihe-in -77.66, 1.58 -57.71, -38.48 APE12-dist-in 10.2466 APE11-dist-in 12.0267 APE10-dist-in 6.1071 APE9-dist-in 3.357 None None None XRAY 2.65 0.217 0.26 A 547.0 457.0 0 26 26 0 [[191, 453]] 1.0 5uvc Homo sapiens AGC_GRK2_HUMAN AGC 3.7e-77 268.3 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5UKLA P25098 31 671 689.0 SIX:702 Type1 Active DFGin 5.5525 13.4547 BLAminus -136.15, 162.37 65.35, 90.8 -91.1, 16.16 287.26, 80.35 -44.51, -43.27 in-in in 8.9358 Saltbr-in 2.6266 HRD-in -76.69, -51.69 80.53, -28.69 in-in-in SNCiii in-in ActLoopNT-in 2.9516 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.59, 119.44 APE9-dihe-na 167.03, -154.05 APE8-dihe-in -112.97, 140.97 APE8-rot-in 300.02 APE67-dihe-in -82.52, 9.1 -61.65, -35.94 APE12-dist-in 10.2011 APE11-dist-in 11.7419 APE10-dist-in 5.8434 APE9-dist-in 3.7561 S670A None None XRAY 2.15 0.184 0.228 A 642.0 630.0 0 26 26 0 [[191, 453]] 1.0 5ukl Homo sapiens AGC_GRK2_HUMAN AGC 5.4e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5HE1A P25098 29 668 689.0 ZS2:701 Type1 Active DFGin 5.7607 13.0739 BLAminus -136.45, 161.18 63.18, 92.12 -104.97, 24.32 295.58, 61.08 -54.15, -39.68 in-in in 8.6303 Saltbr-in 2.9645 HRD-in -75.81, -60.39 89.65, -39.71 in-in-in SNCiii in-in ActLoopNT-in 2.9796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.97, 100.73 APE9-dihe-na -165.78, -165.71 APE8-dihe-in -91.06, 127.63 APE8-rot-in 294.03 APE67-dihe-inflip 109.39, -17.56 -55.26, 129.29 APE12-dist-in 10.3336 APE11-dist-in 12.1323 APE10-dist-in 6.3113 APE9-dist-in 3.8934 S670A None None XRAY 3.15 0.172 0.25 A 642.0 618.0 0 26 26 0 [[191, 453]] 1.0 5he1 Homo sapiens AGC_GRK2_HUMAN AGC 5.4e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 6C2YA P25098 30 668 689.0 EJS:701 Type1 Active DFGin 5.2477 13.1313 BLAminus -133.84, 169.51 63.67, 85.91 -91.46, 28.99 286.98, 69.09 -62.06, -46.79 in-in in 8.7773 Saltbr-in 2.6025 HRD-in -71.8, -47.67 74.94, -21.53 in-in-in SNCiii in-in ActLoopNT-in 3.2292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.32, 147.42 APE9-dihe-na 138.79, -162.57 APE8-dihe-in -110.7, 130.32 APE8-rot-in 292.69 APE67-dihe-inflip 102.38, -19.78 -58.44, 136.12 APE12-dist-in 9.5744 APE11-dist-in 11.9534 APE10-dist-in 5.9756 APE9-dist-in 3.4531 S670A None None XRAY 2.74 0.247 0.292 A 689.0 617.0 2 26 26 0 [[191, 453]] 1.0 6c2y Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 4MK0A P25098 30 668 689.0 29X:60702 Type1 Active DFGin 5.0222 12.5575 BLAminus -114.3, 159.32 62.47, 95.12 -99.09, 26.84 314.83, 15.76 -55.23, -46.17 in-in in 8.7964 Saltbr-in 3.2929 HRD-in -74.82, -46.73 65.86, 15.22 in-in-in SNCiii in-in ActLoopNT-in 2.8054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.22, 138.8 APE9-dihe-na 140.75, -169.47 APE8-dihe-in -90.2, 139.3 APE8-rot-in 300.61 APE67-dihe-inflip 101.57, -12.83 -69.61, 140.12 APE12-dist-in 10.2148 APE11-dist-in 12.1548 APE10-dist-in 6.4186 APE9-dist-in 3.2251 None None None XRAY 2.4 0.179 0.238 A 640.0 630.0 0 26 26 0 [[191, 453]] 1.0 4mk0 Homo sapiens AGC_GRK2_HUMAN AGC 5.3e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 7K7LA P25098 30 668 689.0 W4D:702 Type1 Active DFGin 5.3464 13.407 BLAminus -120.75, 157.11 65.86, 85.74 -89.44, 20.76 269.03, 169.7 -63.22, -26.35 in-in in 9.0879 Saltbr-in 2.7438 HRD-in -83.14, -50.8 72.46, -22.33 in-in-in SNCiii in-in ActLoopNT-in 2.8171 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.43, 143.89 APE9-dihe-na 130.34, -178.78 APE8-dihe-in -87.05, 140.86 APE8-rot-in 300.91 APE67-dihe-inflip 101.09, -17.29 -67.82, 137.73 APE12-dist-in 10.8032 APE11-dist-in 12.386 APE10-dist-in 6.4429 APE9-dist-in 3.6669 None None None XRAY 2.539 0.203 0.244 A 640.0 616.0 0 26 26 0 [[191, 453]] 1.0 7k7l Homo sapiens AGC_GRK2_HUMAN AGC 5.3e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 7K7ZA P25098 30 668 689.0 W4G:701 Type1 Active DFGin 5.2276 13.2609 BLAminus -131.21, 159.45 58.45, 84.74 -81.51, 17.96 273.45, 160.93 -49.98, -46.53 in-in in 9.1503 Saltbr-in 2.6057 HRD-in -69.84, -65.83 82.28, 6.02 in-in-in SNCiii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 129.42 APE9-dihe-na 151.42, -156.98 APE8-dihe-in -108.77, 134.07 APE8-rot-in 292.67 APE67-dihe-inflip 104.4, -17.1 -64.98, 131.58 APE12-dist-in 12.6858 APE11-dist-in 12.3085 APE10-dist-in 6.4852 APE9-dist-in 3.2799 None None None XRAY 2.606 0.207 0.262 A 640.0 625.0 0 26 26 0 [[191, 453]] 1.0 7k7z Homo sapiens AGC_GRK2_HUMAN AGC 5.3e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 3V5WA P25098 30 668 689.0 8PR:701 Type1 Active DFGin 5.1567 12.9917 BLAminus -135.73, 166.74 63.47, 84.47 -90.01, 8.76 284.89, 155.02 -55.83, -32.04 in-in in 8.9278 Saltbr-in 2.9291 HRD-in -75.87, -48.67 77.13, -26.65 in-in-in SNCiii in-in ActLoopNT-in 2.9163 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 132.09 APE9-dihe-na 148.62, -167.37 APE8-dihe-in -102.18, 145.22 APE8-rot-in 303.37 APE67-dihe-in -68.83, -4.06 -70.22, -32.86 APE12-dist-in 10.0001 APE11-dist-in 11.8614 APE10-dist-in 5.9102 APE9-dist-in 3.6888 None None None XRAY 2.07 0.196 0.247 A 689.0 623.0 0 26 26 0 [[191, 453]] 1.0 3v5w Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 4PNKA P25098 30 668 689.0 KZQ:701 Type1 Active DFGin 5.6956 13.3098 BLAminus -131.92, 150.67 73.23, 94.18 -104.4, 20.24 276.38, 72.07 -49.27, -48.99 in-in in 8.8686 Saltbr-in 2.8918 HRD-in -75.55, -46.99 79.65, -28.55 in-in-in SNCiii in-in ActLoopNT-in 3.0292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.99, 151.18 APE9-dihe-na 153.42, -170.47 APE8-dihe-in -97.49, 139.43 APE8-rot-in 296.18 APE67-dihe-inflip 99.83, -0.25 -68.24, 133.65 APE12-dist-in 10.1099 APE11-dist-in 11.7313 APE10-dist-in 5.9401 APE9-dist-in 3.5973 None None None XRAY 2.56 0.194 0.259 A 689.0 625.0 0 26 26 0 [[191, 453]] 1.0 4pnk Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5WG3A P25098 30 668 689.0 AFM:701 Type1 Active DFGin 5.2508 12.6657 BLAminus -140.32, 170.95 56.45, 82.96 -87.3, 21.74 311.79, 174.31 -59.6, -38.71 in-in in 8.9483 Saltbr-in 2.8469 HRD-in -82.02, -43.09 42.08, 25.46 in-in-in SNCiii in-in ActLoopNT-in 3.2573 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.78, 131.07 APE9-dihe-na 153.01, -166.14 APE8-dihe-in -107.02, 132.83 APE8-rot-in 302.54 APE67-dihe-inflip 106.87, -20.46 -62.02, 131.15 APE12-dist-in 10.4276 APE11-dist-in 11.7933 APE10-dist-in 5.9015 APE9-dist-in 3.3586 None None None XRAY 2.896 0.201 0.248 A 689.0 618.0 5 26 26 0 [[191, 453]] 1.0 5wg3 Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5WG4A P25098 31 668 689.0 AFV:701 Type1 Active DFGin 5.3057 12.6907 BLAminus -133.5, 178.66 54.05, 81.87 -91.99, 21.58 286.03, 73.35 -64.61, -41.57 in-in in 8.5477 Saltbr-in 3.1343 HRD-in -85.74, -45.07 68.56, -11.01 in-in-in SNCiii in-in ActLoopNT-in 3.1518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 129.47 APE9-dihe-na 146.73, -166.55 APE8-dihe-in -108.67, 131.04 APE8-rot-in 299.39 APE67-dihe-inflip 106.48, -11.49 -60.32, 128.85 APE12-dist-in 10.344 APE11-dist-in 11.9796 APE10-dist-in 6.1426 APE9-dist-in 3.4618 None None None XRAY 2.31 0.235 0.279 A 689.0 621.0 2 26 26 0 [[191, 453]] 1.0 5wg4 Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5WG5A P25098 30 668 689.0 ZSO:701 Type1 Active DFGin 5.4509 13.0103 BLAminus -128.14, 171.88 56.74, 83.28 -91.88, 32.75 279.7, 68.89 -65.05, -47.67 in-in in 8.625 Saltbr-in 2.6505 HRD-in -77.29, -47.13 67.77, -1.76 in-in-in SNCiii in-in ActLoopNT-in 2.9921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.64, 131.79 APE9-dihe-na 147.8, -171.59 APE8-dihe-in -95.05, 124.52 APE8-rot-in 297.6 APE67-dihe-inflip 97.31, -8.85 -62.05, 143.11 APE12-dist-in 10.4905 APE11-dist-in 12.0444 APE10-dist-in 6.1933 APE9-dist-in 3.3918 None None None XRAY 3.1 0.19 0.232 A 689.0 617.0 3 26 26 0 [[191, 453]] 1.0 5wg5 Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5UUUA P25098 31 538 689.0 QRW:601 Type1.5_Front Active DFGin 5.4075 13.1234 BLAminus -119.49, 148.71 76.08, 97.29 -99.15, 18.56 280.12, 88.0 -55.68, -33.52 in-in in 8.3995 Saltbr-in 2.9715 HRD-in -81.09, -44.67 78.9, -27.11 in-in-in SNCiii in-in ActLoopNT-in 3.1511 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.83, 137.94 APE9-dihe-na 132.21, -156.97 APE8-dihe-in -118.83, 132.35 APE8-rot-in 311.27 APE67-dihe-inflip 94.82, -15.58 -63.39, 132.05 APE12-dist-in 9.9224 APE11-dist-in 11.8901 APE10-dist-in 5.9307 APE9-dist-in 3.5492 None None None XRAY 2.7 0.215 0.257 A 547.0 414.0 0 26 26 0 [[191, 453]] 1.0 5uuu Homo sapiens AGC_GRK2_HUMAN AGC 3.7e-77 268.3 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 5UKKA P25098 30 667 689.0 8DJ:702 Type1.5_Front Active DFGin 5.4401 12.8485 BLAminus -148.52, 179.61 57.76, 73.54 -87.98, 8.97 274.06, 69.08 -60.04, -18.89 in-in in 8.2709 Saltbr-in 2.6689 HRD-in -76.24, -37.94 75.49, -51.75 in-in-in SNCiii in-in ActLoopNT-in 2.9425 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.39, 145.94 APE9-dihe-na 143.2, -151.45 APE8-dihe-in -131.14, 141.32 APE8-rot-in 299.97 APE67-dihe-in -67.12, -33.98 -48.24, -30.82 APE12-dist-in 9.6352 APE11-dist-in 11.8188 APE10-dist-in 5.8456 APE9-dist-in 4.1568 S670A None None XRAY 2.6 0.224 0.281 A 642.0 613.0 0 26 26 0 [[191, 453]] 1.0 5ukk Homo sapiens AGC_GRK2_HUMAN AGC 5.4e-77 267.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 6U7CA P25098 30 669 689.0 Q1Y:701 Type1.5_Front Active DFGin 5.0615 12.4543 BLAminus -136.54, 170.55 57.52, 81.77 -86.77, 20.22 308.16, 7.53 -58.1, -34.47 in-in in 9.0498 Saltbr-in 2.5429 HRD-in -72.35, -46.72 70.07, -13.25 in-in-in SNCiii in-in ActLoopNT-in 3.3699 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.84, 132.95 APE9-dihe-na 147.35, -168.5 APE8-dihe-in -105.63, 128.22 APE8-rot-in 297.44 APE67-dihe-inflip 124.86, -14.55 -55.92, 113.23 APE12-dist-in 10.2056 APE11-dist-in 12.016 APE10-dist-in 6.0719 APE9-dist-in 3.4845 None None None XRAY 2.44 0.237 0.262 A 689.0 631.0 0 26 26 0 [[191, 453]] 1.0 6u7c Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 3CIKA P25098 29 669 689.0 No_ligand No_ligand Inactive DFGin 5.2003 12.94 None -113.38, -84.39 -77.41, 106.5 -85.28, 5.55 272.59, 132.44 -54.41, -34.31 in-in in 8.589 Saltbr-in 2.8304 HRD-in -65.15, -43.87 69.81, -16.37 in-in-in SNCiii in-in ActLoopNT-in 2.8246 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.98, 126.35 APE9-dihe-na 141.75, -159.25 APE8-dihe-in -111.86, 146.5 APE8-rot-in 310.14 APE67-dihe-in -81.13, 3.2 -68.81, -30.14 APE12-dist-in 10.9775 APE11-dist-in 12.0726 APE10-dist-in 6.4171 APE9-dist-in 3.5873 None None None XRAY 2.75 0.208 0.269 A 689.0 619.0 0 26 26 0 [[191, 453]] 1.0 3cik Homo sapiens AGC_GRK2_HUMAN AGC 6.3e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 7PWDA P25098 27 668 689.0 8DS:701 Type1 Inactive DFGin 5.2813 12.9593 None -103.27, -91.53 -83.38, 120.45 -98.95, 11.01 295.2, 164.91 -62.17, -28.84 in-in in 8.7988 Saltbr-in 2.8227 HRD-in -68.27, -51.69 76.81, -22.19 in-in-in SNCiii in-in ActLoopNT-in 2.8256 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.66, 145.62 APE9-dihe-na 123.25, -162.48 APE8-dihe-in -110.04, 138.42 APE8-rot-in 305.66 APE67-dihe-inflip 98.02, -22.76 -65.28, 137.62 APE12-dist-in 10.312 APE11-dist-in 11.9263 APE10-dist-in 6.0194 APE9-dist-in 3.3652 S670A None None XRAY 2.6 0.192 0.23 A 697.0 621.0 0 26 26 0 [[191, 453]] 1.0 7pwd Homo sapiens AGC_GRK2_HUMAN AGC 6.4e-77 267.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 3KRWA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4431 12.512 None -124.43, -69.99 -70.72, 103.06 -103.15, 18.82 281.61, 154.56 -63.74, -46.79 in-in in 8.9073 Saltbr-in 2.6208 HRD-in -80.35, -50.37 71.38, -3.06 in-in-in SNCiii in-in ActLoopNT-in 2.7506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.68, 135.05 APE9-dihe-na 136.51, -178.33 APE8-dihe-in -97.44, 143.34 APE8-rot-in 311.93 APE67-dihe-in -81.84, -17.98 -65.75, -16.48 APE12-dist-in 9.7737 APE11-dist-in 11.7182 APE10-dist-in 5.7635 APE9-dist-in 3.2649 None None None XRAY 2.9 0.216 0.265 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krw Homo sapiens AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_HUMAN 3KRXA P25098 30 671 689.0 BA1:690 Type1 Inactive DFGin 5.4192 12.8449 None -125.39, -77.94 -69.67, 105.65 -105.64, 33.0 281.38, 161.16 -76.22, -41.07 in-in in 9.1809 Saltbr-in 2.9453 HRD-in -81.43, -47.09 70.32, -0.2 in-in-in SNCiii in-in ActLoopNT-in 2.7468 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.75, 134.45 APE9-dihe-na 144.08, -171.31 APE8-dihe-in -102.11, 138.21 APE8-rot-in 300.04 APE67-dihe-in -91.64, -15.37 -61.65, -13.24 APE12-dist-in 9.2638 APE11-dist-in 11.5714 APE10-dist-in 5.62 APE9-dist-in 3.2776 None None None XRAY 3.1 0.232 0.27 A 688.0 618.0 0 26 26 0 [[191, 453]] 1.0 3krx Homo sapiens AGC_GRK2_HUMAN AGC 6.2e-77 267.6 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1

AGC_GRK2 (Beta-adrenergic receptor kinase 1)

Total number of chains: 18
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin None 10 55.6% 3PVUA
DFGin ABAminus 4 22.2% 8JPDG
DFGin BLAminus 4 22.2% 5HE0A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
GRK2 ARBK1_BOVIN 5HE0A P21146 30 668 689.0 453:701 Type1 Active DFGin 5.2592 13.1171 BLAminus -137.72, 161.16 67.72, 86.34 -84.98, 14.88 287.85, 80.12 -42.13, -60.12 in-in in 8.4671 Saltbr-in 2.8678 HRD-in -68.65, -49.34 77.87, -29.18 in-in-in SNCiii in-in ActLoopNT-in 2.8588 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.25, 120.14 APE9-dihe-na 171.2, -142.82 APE8-dihe-in -122.87, 132.42 APE8-rot-in 285.63 APE67-dihe-inflip 113.92, -33.46 -57.37, 128.9 APE12-dist-in 10.1735 APE11-dist-in 11.7707 APE10-dist-in 5.8798 APE9-dist-in 3.5488 S670A None None XRAY 2.56 0.205 0.264 A 641.0 621.0 0 26 26 0 [[191, 453]] 1.0 5he0 Bos taurus AGC_GRK2_BOVIN AGC 5.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 5HE2A P21146 30 668 689.0 F0S:701 Type1 Active DFGin 5.2664 13.4322 BLAminus -127.84, 162.02 76.97, 74.62 -82.13, 19.63 285.89, 54.35 -44.91, -55.91 in-in in 8.6986 Saltbr-in 2.6713 HRD-in -87.07, -48.72 79.5, -27.96 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.3, 135.41 APE9-dihe-na 128.88, -173.45 APE8-dihe-in -85.86, 172.32 APE8-rot-in 301.72 APE67-dihe-in -88.54, 16.07 -85.52, -45.68 APE12-dist-in 10.698 APE11-dist-in 11.9311 APE10-dist-in 5.9928 APE9-dist-in 3.7816 S670A None None XRAY 2.79 0.202 0.277 A 641.0 628.0 0 26 26 0 [[191, 453]] 1.0 5he2 Bos taurus AGC_GRK2_BOVIN AGC 5.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 5HE3A P21146 30 670 689.0 FF1:702 Type1 Active DFGin 5.4706 13.1124 BLAminus -130.61, 154.77 82.75, 74.09 -80.19, 15.36 283.76, 73.33 -31.6, -75.24 in-in in 8.613 Saltbr-in 2.7525 HRD-in -66.32, -31.89 63.86, -19.84 in-in-in SNCiii in-in ActLoopNT-in 2.9166 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.68, 142.9 APE9-dihe-na 127.74, 174.69 APE8-dihe-in -90.13, 145.29 APE8-rot-in 301.32 APE67-dihe-inflip 112.74, -14.85 -68.46, 126.13 APE12-dist-in 10.205 APE11-dist-in 11.7078 APE10-dist-in 5.915 APE9-dist-in 3.371 None None None XRAY 2.74 0.198 0.257 A 641.0 623.0 0 26 26 0 [[191, 453]] 1.0 5he3 Bos taurus AGC_GRK2_BOVIN AGC 5.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 5UKMA P21146 31 669 689.0 T0E:701 Type1 Active DFGin 5.5585 13.1317 BLAminus -130.36, 150.32 61.48, 90.2 -96.51, 21.64 296.35, 62.89 -55.13, -59.92 in-in in 9.0172 Saltbr-in 2.7861 HRD-in -71.89, -48.96 73.51, -73.8 in-in-in SNCiii in-in ActLoopNT-in 3.1669 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.94, 135.34 APE9-dihe-na 121.47, 173.74 APE8-dihe-in -77.03, 143.73 APE8-rot-in 316.68 APE67-dihe-in -68.91, -23.51 -68.56, -33.79 APE12-dist-in 10.3025 APE11-dist-in 11.6096 APE10-dist-in 5.8336 APE9-dist-in 5.3132 S670A None None XRAY 3.03 0.2 0.252 A 695.0 621.0 0 26 26 0 [[191, 453]] 1.0 5ukm Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7B P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.1989 12.4485 ABAminus -130.8, -59.92 -98.26, 108.63 -91.58, -9.04 306.19, 95.69 -36.4, -48.74 in-out in 8.8033 Saltbr-out 4.6419 HRD-in -77.09, -44.3 73.62, -27.39 out-in-in SNCoii in-in ActLoopNT-in 2.7591 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.17, 125.32 APE9-dihe-na 152.82, 174.56 APE8-dihe-in -87.32, 142.62 APE8-rot-in 313.75 APE67-dihe-in -64.86, -36.54 -62.56, -29.46 APE12-dist-in 9.8182 APE11-dist-in 11.5603 APE10-dist-in 5.5731 APE9-dist-in 4.0361 S670A None None XRAY 4.5 0.226 0.279 B 689.0 608.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 8JPBG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.5082 12.2136 ABAminus -113.28, -56.44 -93.74, 100.06 -93.25, 26.0 307.53, 3.55 -63.32, -43.2 in-out in 8.9334 Saltbr-out 4.2174 HRD-out -93.17, 87.64 -73.74, -9.71 out-in-in SNCoii in-in ActLoopNT-in 2.7258 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.15, 142.89 APE9-dihe-na 142.59, -152.8 APE8-dihe-in -124.3, 137.48 APE8-rot-in 299.05 APE67-dihe-inflip 90.41, -8.27 -58.8, 137.88 APE12-dist-in 9.9025 APE11-dist-in 12.0099 APE10-dist-in 6.0986 APE9-dist-in 3.6298 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpb Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 8JPCG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.385 12.1571 ABAminus -113.22, -56.58 -93.6, 101.44 -93.44, 27.48 306.81, 9.79 -63.79, -45.14 in-out in 8.9895 Saltbr-out 4.6535 HRD-out -92.62, 94.67 -75.66, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6526 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.27, 130.92 APE9-dihe-na 162.84, -151.71 APE8-dihe-in -129.7, 130.81 APE8-rot-in 302.62 APE67-dihe-inflip 97.48, -17.5 -57.09, 134.46 APE12-dist-in 9.7132 APE11-dist-in 11.9892 APE10-dist-in 5.9887 APE9-dist-in 4.3163 A292P,R295I,S455D None None EM 3.07 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpc Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 8JPDG P21146 2 659 689.0 STU:701 Type1 Inactive DFGin 5.3847 12.1571 ABAminus -113.24, -56.55 -93.57, 101.39 -93.42, 27.53 306.84, 9.79 -63.78, -45.12 in-out in 8.9895 Saltbr-out 4.6534 HRD-out -92.61, 94.65 -75.65, -35.58 out-in-in SNCoii in-in ActLoopNT-in 2.6534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.32, 130.92 APE9-dihe-na 162.83, -151.7 APE8-dihe-in -129.72, 130.82 APE8-rot-in 302.58 APE67-dihe-inflip 97.48, -17.49 -57.11, 134.43 APE12-dist-in 9.7137 APE11-dist-in 11.9887 APE10-dist-in 5.9885 APE9-dist-in 4.3171 A292P,R295I,S455D None None EM 2.81 999.0 999.0 G 688.0 658.0 0 26 26 0 [[191, 453]] 1.0 8jpd Bos taurus AGC_GRK2_BOVIN AGC 1.7e-76 267.2 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1OMWA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.448 13.0685 None -112.27, -91.9 -67.18, 126.78 -99.0, 7.24 286.96, 109.41 -44.09, -46.49 in-in in 8.9372 Saltbr-in 3.4107 HRD-in -73.22, -52.41 80.02, -28.79 in-in-in SNCiii in-in ActLoopNT-in 2.8622 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.71, 128.56 APE9-dihe-na 124.77, -168.54 APE8-dihe-in -89.28, 150.91 APE8-rot-in 295.71 APE67-dihe-in -77.59, -9.92 -72.81, -27.02 APE12-dist-in 10.5885 APE11-dist-in 11.8774 APE10-dist-in 6.1942 APE9-dist-in 3.5029 S670A None None XRAY 2.5 0.216 0.252 A 689.0 614.0 0 26 26 0 [[191, 453]] 1.0 1omw Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7A P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2239 12.3565 None -125.66, -66.29 -94.21, 107.11 -86.73, -10.11 307.87, 97.53 -38.26, -47.46 in-out in 8.8531 Saltbr-out 4.6372 HRD-in -74.94, -45.18 74.24, -26.22 out-in-in SNCoii in-in ActLoopNT-in 2.7715 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.74, 123.21 APE9-dihe-na 155.55, 174.57 APE8-dihe-in -86.11, 141.22 APE8-rot-in 314.43 APE67-dihe-in -66.31, -34.76 -64.21, -27.3 APE12-dist-in 9.8313 APE11-dist-in 11.5432 APE10-dist-in 5.5926 APE9-dist-in 3.9926 S670A None None XRAY 4.5 0.226 0.279 A 689.0 608.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7C P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2163 12.2674 None -130.34, -66.38 -92.79, 106.85 -85.97, -13.2 309.12, 95.06 -35.96, -48.47 in-out in 8.8136 Saltbr-out 4.7358 HRD-in -75.86, -48.89 75.97, -29.41 out-in-in SNCoii in-in ActLoopNT-in 2.721 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.29, 128.8 APE9-dihe-na 145.96, 173.8 APE8-dihe-in -87.44, 141.12 APE8-rot-in 314.72 APE67-dihe-in -67.09, -36.43 -60.22, -25.52 APE12-dist-in 9.7747 APE11-dist-in 11.5691 APE10-dist-in 5.6074 APE9-dist-in 4.0582 S670A None None XRAY 4.5 0.226 0.279 C 689.0 607.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 1YM7D P21146 29 656 689.0 No_ligand No_ligand Inactive DFGin 5.2341 12.3436 None -128.88, -67.33 -92.65, 105.41 -87.88, -10.71 307.83, 96.53 -37.49, -49.46 in-out in 8.801 Saltbr-out 4.7459 HRD-in -72.13, -45.13 72.62, -27.86 out-in-in SNCoii in-in ActLoopNT-in 2.7633 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.27, 125.22 APE9-dihe-na 149.39, 173.11 APE8-dihe-in -84.5, 141.69 APE8-rot-in 315.18 APE67-dihe-in -66.11, -35.98 -62.26, -27.83 APE12-dist-in 9.7362 APE11-dist-in 11.4974 APE10-dist-in 5.5333 APE9-dist-in 4.0286 S670A None None XRAY 4.5 0.226 0.279 D 689.0 599.0 0 26 26 0 [[191, 453]] 1.0 1ym7 Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 2BCJA P21146 28 667 689.0 No_ligand No_ligand Inactive DFGin 5.1531 12.3754 None -114.23, -125.71 -23.26, 91.28 -81.33, 0.62 275.63, 158.44 -51.51, -42.54 in-in in 8.6198 Saltbr-in 2.6334 HRD-in -86.19, -45.87 70.94, -23.92 in-in-in SNCiii in-in ActLoopNT-in 2.7186 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.73, 137.19 APE9-dihe-na 118.03, -177.98 APE8-dihe-in -75.0, 121.63 APE8-rot-in 302.92 APE67-dihe-in -97.57, -19.7 -76.89, 19.37 APE12-dist-in 11.0395 APE11-dist-in 11.9406 APE10-dist-in 6.0057 APE9-dist-in 3.715 S670A None None XRAY 3.061 0.236 0.292 A 689.0 624.0 0 26 26 0 [[191, 453]] 1.0 2bcj Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3UZSA P21146 29 671 689.0 No_ligand No_ligand Inactive DFGin 5.731 11.1485 None -107.21, -110.21 -68.72, 97.64 -52.38, -56.06 299.08, 3.09 42.56, -75.63 in-out in 9.0047 Saltbr-out 3.9207 HRD-in -77.33, -41.02 60.69, 32.77 out-in-out SNCoio in-out ActLoopNT-in 3.5286 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -98.18, 142.14 APE9-dihe-na 139.16, 169.96 APE8-dihe-in -74.03, 124.78 APE8-rot-in 315.02 APE67-dihe-out 166.07, -43.85 -59.08, 78.84 APE12-dist-in 10.2386 APE11-dist-in 12.0969 APE10-dist-in 6.31 APE9-dist-in 3.5138 S670A None None XRAY 4.52 0.188 0.268 A 689.0 609.0 20 26 26 0 [[191, 453]] 1.0 3uzs Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3UZTA P21146 30 656 689.0 No_ligand No_ligand Inactive DFGin 5.216 12.499 None -94.28, -95.77 -83.37, 90.84 -54.75, -37.85 271.69, 47.64 -2.65, -69.38 in-out in 8.8257 Saltbr-out 5.0807 HRD-in -72.79, -37.98 67.02, -27.54 out-in-in SNCoii in-in ActLoopNT-in 3.085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -99.51, 148.65 APE9-dihe-na 138.76, 168.6 APE8-dihe-in -71.39, 126.55 APE8-rot-in 294.92 APE67-dihe-in -71.95, -17.71 -54.34, -25.29 APE12-dist-in 9.5328 APE11-dist-in 12.0098 APE10-dist-in 5.9885 APE9-dist-in 3.8685 S670A None None XRAY 3.51 0.22 0.317 A 689.0 586.0 12 26 26 0 [[191, 453]] 1.0 3uzt Bos taurus AGC_GRK2_BOVIN AGC 6.3e-77 268.8 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3PSCA P21146 29 668 689.0 No_ligand No_ligand Inactive DFGin 5.4842 12.8251 None -112.1, -116.4 -50.02, 128.26 -100.71, 13.15 287.53, 88.47 -45.02, -46.74 in-in in 8.8883 Saltbr-in 3.1136 HRD-in -73.4, -47.49 67.75, 0.38 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.59, 142.02 APE9-dihe-na 121.44, 174.37 APE8-dihe-in -79.3, 138.73 APE8-rot-in 323.05 APE67-dihe-in -80.94, 3.9 -61.06, -31.71 APE12-dist-in 10.1172 APE11-dist-in 11.7629 APE10-dist-in 5.9289 APE9-dist-in 3.1916 S670A None None XRAY 2.67 0.225 0.257 A 695.0 614.0 0 26 26 0 [[191, 453]] 1.0 3psc Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3PVUA P21146 30 668 689.0 QRW:800 Type1 Inactive DFGin 5.4293 12.5496 None -114.2, -126.97 -29.78, 116.79 -95.83, 7.38 283.37, 161.7 -55.56, -22.85 in-in in 8.7486 Saltbr-in 2.9863 HRD-in -71.34, -46.23 80.59, -11.92 in-in-in SNCiii in-in ActLoopNT-in 2.9271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.26, 142.91 APE9-dihe-na 117.3, -165.9 APE8-dihe-in -102.62, 148.45 APE8-rot-in 314.0 APE67-dihe-in -77.54, 11.33 -67.23, -35.08 APE12-dist-in 10.2837 APE11-dist-in 11.8902 APE10-dist-in 6.1863 APE9-dist-in 3.4202 S670A None None XRAY 2.48 0.229 0.274 A 695.0 609.0 0 26 26 0 [[191, 453]] 1.0 3pvu Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1
GRK2 ARBK1_BOVIN 3PVWA P21146 29 668 689.0 QRX:800 Type1 Inactive DFGin 5.249 12.3972 None -104.93, -94.33 -60.0, 121.61 -95.37, 6.96 285.31, 4.38 -65.85, -19.47 in-in in 8.7495 Saltbr-in 3.07 HRD-in -69.01, -52.71 78.6, -13.88 in-in-in SNCiii in-in ActLoopNT-in 2.9188 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.25, 142.6 APE9-dihe-na 127.77, 176.65 APE8-dihe-in -84.9, 148.79 APE8-rot-in 327.3 APE67-dihe-in -77.16, 13.46 -65.86, -42.83 APE12-dist-in 10.7375 APE11-dist-in 12.1865 APE10-dist-in 6.4122 APE9-dist-in 3.337 S670A None None XRAY 2.49 0.239 0.285 A 695.0 613.0 0 26 26 0 [[191, 453]] 1.0 3pvw Bos taurus AGC_GRK2_BOVIN AGC 6.4e-77 268.7 1.0 260.0 260.0 334 335 336 338 340 220 239 243 314 316 315 317.0 373 360 355 354 353 352 351 350 349 272 Beta-adrenergic receptor kinase 1