TYR_FGFR4 (Fibroblast growth factor receptor 4)

Total number of chains: 56
Active chains: 2
Family: TYR
Uniprot: FGFR4_HUMAN
Kinase Domain Residues: 467 - 745
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 42 75.0% 8KH8A
DFGin None 4 7.1% 4TYEA
DFGout BBAminus 4 7.1% 4UXQA
DFGin BLAminus 2 3.6% AF-P22455-K1A
DFGin BLBplus 2 3.6% 8KH9A
DFGout None 1 1.8% 4QRCA
None None 1 1.8% 5NUDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P22455-K1A 459 753 802.0 No_ligand No_ligand Active DFGin 6.574 13.785 BLAminus -135.33, -173.77 55.98, 70.34 -87.24, 10.27 289.35, 94.13 -59.23, -30.92 in-in in 7.511 Saltbr-in 2.595 HRD-in -72.07, -43.39 66.46, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.52, 129.24 APE9-dihe-in -137.27, 151.64 APE8-dihe-in -78.22, 78.83 APE8-rot-na 36.58 APE67-dihe-in -65.35, -13.99 -47.37, -43.33 APE12-dist-na 14.384 APE11-dist-na 9.859 APE10-dist-na 10.001 APE9-dist-in 6.46 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[467, 745]] 1.0 AF-P22455-K1 TYR_FGFR4_HUMAN TYR 1e-100 342.3 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
AF-P22455-K3A 459 753 802.0 No_ligand No_ligand Active DFGin 6.149 13.447 BLAminus -140.69, -177.1 59.37, 67.02 -80.26, 11.26 289.47, 99.81 -58.5, -28.48 in-in in 7.979 Saltbr-in 2.661 HRD-in -82.71, -44.63 62.67, -5.09 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.76, 137.79 APE9-dihe-in -134.14, 131.39 APE8-dihe-in -83.17, 63.92 APE8-rot-na 35.81 APE67-dihe-in -68.87, -6.04 -46.28, -47.07 APE12-dist-na 13.462 APE11-dist-na 9.758 APE10-dist-na 8.185 APE9-dist-in 6.662 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[467, 745]] 1.0 AF-P22455-K3 TYR_FGFR4_HUMAN TYR 1e-100 342.3 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4QQJA 454 752 802.0 No_ligand No_ligand Inactive DFGin 5.518 13.246 BLAplus -118.0, 159.35 59.24, 32.52 -80.61, -12.66 51.69, 84.73 -110.12, 11.1 in-in in 7.686 Saltbr-in 2.81 HRD-in -72.5, -55.76 83.76, -10.09 in-out-out SNCioo out-out ActLoopNT-out 8.404 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -77.21, 142.6 APE9-dihe-in -111.29, 91.44 APE8-dihe-out -57.79, -24.74 APE8-rot-na 330.32 APE67-dihe-in -72.79, -4.34 -56.9, -23.16 APE12-dist-na 18.828 APE11-dist-na 20.839 APE10-dist-na 16.978 APE9-dist-out 11.757 C477A,V550L,R664E None None XRAY 1.682 0.195 0.22 A 323 282 17 0 0 0 [[467, 745]] 1.0 4qqj TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4QQTA 454 750 802.0 No_ligand No_ligand Inactive DFGin 5.306 12.668 BLAplus -114.06, 158.28 58.5, 36.24 -80.5, -13.9 51.72, 86.53 -109.31, 19.2 in-in in 7.276 Saltbr-in 2.732 HRD-in -70.87, -53.69 82.76, -12.35 in-out-out SNCioo out-out ActLoopNT-out 8.155 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.24, 139.82 APE9-dihe-in -109.2, 91.15 APE8-dihe-out -56.36, -21.76 APE8-rot-na 332.77 APE67-dihe-in -69.44, -8.72 -57.84, -25.29 APE12-dist-na 19.372 APE11-dist-na 21.092 APE10-dist-na 17.099 APE9-dist-out 11.866 C477A,R664E None None XRAY 1.501 0.223 0.248 A 323 283 14 0 0 0 [[467, 745]] 1.0 4qqt TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4TYGA 447 751 802.0 No_ligand No_ligand Inactive DFGin 5.036 13.264 BLAplus -113.04, 168.56 59.21, 26.28 -74.51, -27.59 55.83, 78.88 -116.06, 38.07 in-in in 8.36 Saltbr-in 2.943 HRD-in -76.3, -50.92 72.53, 0.99 in-out-out SNCioo out-out ActLoopNT-out 9.589 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -69.06, 164.09 APE9-dihe-in -68.59, 127.31 APE8-dihe-in -75.26, 70.92 APE8-rot-na 33.17 APE67-dihe-in -73.51, -8.42 -61.75, -39.15 APE12-dist-na 16.414 APE11-dist-na 14.362 APE10-dist-na 17.016 APE9-dist-out 8.583 None None None XRAY 2.4 0.204 0.238 A 311 290 15 0 0 0 [[467, 745]] 1.0 4tyg TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7WCXA 453 752 802.0 90F:801 Type1 Inactive DFGin 5.263 13.141 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.792 Saltbr-in 2.511 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.644 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.074 APE11-dist-na 20.85 APE10-dist-na 16.822 APE9-dist-out 11.904 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcx TYR_FGFR4_HUMAN TYR 7e-101 342.8 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7YBXA 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.487 13.153 BLAplus -117.55, 160.19 54.53, 49.02 -91.8, -26.59 44.5, 84.85 -106.57, 50.06 in-in in 7.559 Saltbr-in 2.569 HRD-in -80.18, -45.42 74.32, -9.85 in-out-out SNCioo out-out ActLoopNT-out 8.685 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.48, 136.62 APE9-dihe-in -109.39, 93.32 APE8-dihe-out -58.06, -17.41 APE8-rot-na 334.8 APE67-dihe-in -75.5, -1.38 -66.17, -23.12 APE12-dist-na 19.683 APE11-dist-na 21.389 APE10-dist-na 17.29 APE9-dist-out 11.925 V550M,R664E None None XRAY 2.233 0.182 0.22 A 309 300 0 0 0 0 [[467, 745]] 1.0 7ybx TYR_FGFR4_HUMAN TYR 7e-101 342.8 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7WCWA 453 752 802.0 90F:801 Type1 Inactive DFGin 5.839 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.582 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.633 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.435 APE11-dist-na 20.996 APE10-dist-na 16.929 APE9-dist-out 11.84 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcw TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7YBPA 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.694 13.112 BLAplus -118.3, 157.64 52.77, 54.66 -79.94, -64.81 29.11, 91.47 -101.86, 63.71 in-in in 7.529 Saltbr-in 2.425 HRD-in -81.24, -48.67 73.48, -6.26 in-out-out SNCioo out-out ActLoopNT-out 8.825 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.22, 136.85 APE9-dihe-in -109.57, 90.67 APE8-dihe-out -55.15, -19.67 APE8-rot-na 333.84 APE67-dihe-in -75.88, -4.09 -65.13, -21.92 APE12-dist-na 20.005 APE11-dist-na 21.526 APE10-dist-na 17.387 APE9-dist-out 11.892 V550L,R664E None None XRAY 2.243 0.178 0.214 A 309 300 0 0 0 0 [[467, 745]] 1.0 7ybp TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
8KH8A 453 751 802.0 VVW:802 Type1 Inactive DFGin 5.473 13.134 BLAplus -118.53, 158.78 61.66, 36.82 -83.32, -20.9 47.14, 88.2 -101.16, 42.7 in-in in 7.514 Saltbr-in 2.669 HRD-in -75.42, -56.09 83.49, -11.36 in-out-out SNCioo out-out ActLoopNT-out 8.748 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.21, 138.97 APE9-dihe-in -107.92, 92.76 APE8-dihe-out -57.64, -22.35 APE8-rot-na 332.41 APE67-dihe-in -70.15, -6.75 -57.07, -25.4 APE12-dist-na 19.944 APE11-dist-na 21.486 APE10-dist-na 17.34 APE9-dist-out 11.91 C477A,V550L,R664E None None XRAY 1.49 0.169 0.197 A 309 299 0 0 0 0 [[467, 745]] 1.0 8kh8 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6JPJA 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.658 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.247 Saltbr-in 2.318 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.002 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.294 APE11-dist-na 21.068 APE10-dist-na 17.129 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311 299 0 0 0 0 [[467, 745]] 1.0 6jpj TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
9K0IA 453 752 802.0 A1EEW:801 Type1 Inactive DFGin 5.309 12.763 BLAplus -115.86, 158.69 55.98, 44.95 -85.41, -17.3 44.0, 85.95 -114.13, 46.58 in-out in 7.348 Saltbr-out 4.876 HRD-in -75.84, -47.79 74.65, -0.7 out-out-out SNCooo out-out ActLoopNT-out 8.556 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.32, 134.99 APE9-dihe-in -108.67, 92.7 APE8-dihe-out -58.49, -17.91 APE8-rot-na 335.2 APE67-dihe-in -74.49, -4.34 -64.54, -23.8 APE12-dist-na 19.445 APE11-dist-na 21.037 APE10-dist-na 16.938 APE9-dist-out 11.87 None None None XRAY 2.236 0.178 0.217 A 311 300 0 0 0 0 [[467, 745]] 1.0 9k0i TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
9K0JA 453 752 802.0 A1EEX:801 Type1 Inactive DFGin 5.314 12.97 BLAplus -112.37, 155.75 53.23, 48.1 -84.71, -20.48 44.35, 88.64 -103.37, 33.18 in-in in 7.302 Saltbr-in 2.352 HRD-in -79.51, -52.63 79.39, -8.08 in-out-out SNCioo out-out ActLoopNT-out 8.618 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.26, 135.8 APE9-dihe-in -108.17, 93.1 APE8-dihe-out -57.75, -21.67 APE8-rot-na 334.34 APE67-dihe-in -72.28, -6.39 -60.48, -25.43 APE12-dist-na 19.657 APE11-dist-na 21.23 APE10-dist-na 17.112 APE9-dist-out 11.85 None None None XRAY 2.068 0.168 0.205 A 311 300 0 0 0 0 [[467, 745]] 1.0 9k0j TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
8W5CA 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.074 12.626 BLAplus -113.45, 160.91 56.16, 49.61 -96.83, -7.74 55.25, 86.57 -110.59, 38.95 in-in in 7.449 Saltbr-in 2.888 HRD-in -80.69, -46.77 71.02, -3.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -45.86 APE8-dihe-in -77.5, 69.04 APE8-rot-na 31.31 APE67-dihe-in -69.88, -10.46 -68.35, -23.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.017 None None None XRAY 2.3 0.231 0.264 A 300 267 33 0 0 17 [[467, 745]] 1.0 8w5c TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
8W5CB 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.119 12.687 BLAplus -112.49, 158.46 58.84, 48.55 -96.24, -11.93 55.51, 85.76 -106.62, 34.09 in-in in 7.515 Saltbr-in 2.715 HRD-in -78.98, -47.31 70.01, -1.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.73 APE8-dihe-in -76.63, 74.51 APE8-rot-na 30.6 APE67-dihe-in -68.94, -14.77 -70.82, -21.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.987 None None None XRAY 2.3 0.231 0.264 B 300 263 37 0 0 17 [[467, 745]] 1.0 8w5c TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7VJLA 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.301 12.42 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.485 Saltbr-in 2.904 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301 263 37 0 0 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7VJLB 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.405 13.204 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.876 Saltbr-in 2.665 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301 266 35 0 0 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6YI8A 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.052 12.585 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.129 APE9-dist-out 9.562 None None None XRAY 2.13 0.198 0.231 A 307 277 24 0 0 15 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6YI8B 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.551 13.074 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.399 Saltbr-in 2.814 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.081 None None None XRAY 2.13 0.198 0.231 B 307 270 32 0 0 18 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
5NUDA 453 753 802.0 99K:60801 Type1 Inactive DFGin 5.601 13.131 BLAplus -103.97, 165.83 57.11, 38.22 -87.24, -12.04 51.74, 90.01 -124.91, 999.0 in-none in 7.746 Saltbr-none 999.0 HRD-in -60.07, -52.99 79.18, -24.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -112.95 APE9-dihe-in -78.26, 150.38 APE8-dihe-in -83.02, 51.4 APE8-rot-na 27.64 APE67-dihe-in -63.02, -12.3 -43.5, -50.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.744 None None None XRAY 2.5 999.0 999.0 A 307 267 34 0 0 17 [[467, 745]] 1.0 5nud TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4TYIA 447 750 802.0 38O:60801 Type1 Inactive DFGin 5.017 12.757 BLAplus -124.41, 161.93 65.25, 9.26 -54.13, -39.53 65.77, 95.11 -82.78, -10.75 in-out in 7.441 Saltbr-out 5.518 HRD-out -72.43, 150.77 -73.64, -70.77 out-out-out SNCooo out-out ActLoopNT-out 8.032 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.18 APE8-dihe-in -82.6, 72.32 APE8-rot-na 33.83 APE67-dihe-in -58.23, -33.51 -75.34, -45.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.293 None None None XRAY 3.4 0.281 0.34 A 311 276 28 0 0 14 [[467, 745]] 1.0 4tyi TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7WCTA 453 752 802.0 90F:801 Type1 Inactive DFGin 5.499 13.008 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.476 Saltbr-in 2.881 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.463 APE11-dist-na 21.045 APE10-dist-na 17.074 APE9-dist-out 11.772 R664E None None XRAY 2.106 0.184 0.217 A 311 300 0 0 0 0 [[467, 745]] 1.0 7wct TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7YBOA 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.424 13.004 BLAplus -109.16, 160.64 54.99, 45.18 -87.51, -29.93 42.89, 87.09 -102.4, 91.8 in-in in 7.638 Saltbr-in 3.524 HRD-in -80.44, -50.18 72.25, -3.15 in-out-out SNCioo out-out ActLoopNT-out 8.547 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -92.41, 138.05 APE9-dihe-in -107.71, 88.36 APE8-dihe-out -54.72, -19.34 APE8-rot-na 336.83 APE67-dihe-in -77.24, 0.55 -64.65, -24.27 APE12-dist-na 18.682 APE11-dist-na 20.466 APE10-dist-na 16.682 APE9-dist-out 11.546 R664E None None XRAY 2.307 0.209 0.254 A 311 294 6 0 0 0 [[467, 745]] 1.0 7ybo TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7YC1A 453 752 802.0 IIQ:801 Type1 Inactive DFGin 5.797 12.777 BLAplus -117.27, 155.16 56.14, 51.47 -92.56, -26.45 40.46, 83.33 -101.9, 30.14 in-in in 7.368 Saltbr-in 2.361 HRD-in -69.13, -51.39 74.34, -2.39 in-out-out SNCioo out-out ActLoopNT-out 8.434 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.9, 135.56 APE9-dihe-in -107.22, 92.14 APE8-dihe-out -55.34, -21.49 APE8-rot-na 335.34 APE67-dihe-in -73.76, 1.53 -66.5, -22.57 APE12-dist-na 19.984 APE11-dist-na 21.568 APE10-dist-na 17.463 APE9-dist-out 11.924 R664E None None XRAY 2.535 0.185 0.226 A 311 300 0 0 0 0 [[467, 745]] 1.0 7yc1 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7YC3A 453 752 802.0 IIW:801 Type1 Inactive DFGin 5.327 12.527 BLAplus -110.77, 158.7 57.83, 39.6 -81.75, -23.54 48.21, 88.5 -97.33, 32.48 in-in in 7.226 Saltbr-in 2.622 HRD-in -77.12, -53.67 78.69, -9.75 in-out-out SNCioo out-out ActLoopNT-out 8.428 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.63, 139.81 APE9-dihe-in -109.42, 92.27 APE8-dihe-out -57.58, -22.6 APE8-rot-na 330.14 APE67-dihe-in -71.59, -6.73 -57.28, -26.46 APE12-dist-na 19.898 APE11-dist-na 21.507 APE10-dist-na 17.326 APE9-dist-out 11.9 R664E None None XRAY 1.987 0.163 0.196 A 311 300 0 0 0 0 [[467, 745]] 1.0 7yc3 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
8KH6A 454 750 802.0 VVI:802 Type1 Inactive DFGin 5.815 12.912 BLAplus -119.68, 156.05 60.85, 41.93 -89.33, -24.21 45.12, 83.84 -107.44, 54.7 in-in in 7.349 Saltbr-in 2.208 HRD-in -74.63, -55.79 82.32, -9.59 in-out-out SNCioo out-out ActLoopNT-out 8.7 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.33, 136.78 APE9-dihe-in -108.3, 90.73 APE8-dihe-out -60.36, -21.53 APE8-rot-na 335.21 APE67-dihe-in -71.62, -5.23 -55.35, -27.56 APE12-dist-na 19.541 APE11-dist-na 21.277 APE10-dist-na 17.137 APE9-dist-out 11.92 R664E None None XRAY 1.62 0.205 0.228 A 311 289 8 0 0 0 [[467, 745]] 1.0 8kh6 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
8KH7A 454 751 802.0 VVW:802 Type1 Inactive DFGin 5.276 12.722 BLAplus -115.76, 162.05 57.7, 35.04 -83.79, -12.86 51.09, 87.09 -105.89, 24.32 in-in in 7.417 Saltbr-in 2.782 HRD-in -69.92, -54.01 83.03, -10.74 in-out-out SNCioo out-out ActLoopNT-out 8.514 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -75.04, 139.88 APE9-dihe-in -109.97, 90.79 APE8-dihe-out -58.47, -20.09 APE8-rot-na 333.49 APE67-dihe-in -69.7, -7.45 -60.7, -23.51 APE12-dist-na 19.798 APE11-dist-na 21.421 APE10-dist-na 17.266 APE9-dist-out 11.991 R664E None None XRAY 1.52 0.166 0.195 A 311 290 8 0 0 0 [[467, 745]] 1.0 8kh7 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6IUOA 445 750 802.0 AWX:60801 Type1 Inactive DFGin 5.154 13.899 BLAplus -116.17, 174.07 60.09, 13.1 -64.05, -29.8 62.3, 87.1 -83.94, 18.54 in-in in 8.028 Saltbr-in 2.999 HRD-in -65.57, -53.25 79.62, -17.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.56 APE8-dihe-out -49.41, -24.26 APE8-rot-na 19.79 APE67-dihe-in -70.32, -14.96 -48.88, -39.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.628 R664E None None XRAY 2.3 0.188 0.232 A 322 274 32 0 0 17 [[467, 745]] 1.0 6iuo TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6IUPA 452 750 802.0 AX0:801 Type1 Inactive DFGin 5.074 13.526 BLAplus -116.15, 153.2 62.1, 31.67 -67.34, -18.6 49.7, 87.36 -110.99, 17.09 in-in in 8.124 Saltbr-in 2.77 HRD-in -75.32, -53.06 85.17, -10.28 in-out-out SNCioo out-out ActLoopNT-out 8.443 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.61, 140.51 APE9-dihe-in -109.08, 92.15 APE8-dihe-out -61.13, -19.99 APE8-rot-na 336.97 APE67-dihe-in -72.51, -7.5 -57.22, -22.29 APE12-dist-na 18.53 APE11-dist-na 20.71 APE10-dist-na 16.798 APE9-dist-out 11.949 R664E None None XRAY 2.0 0.172 0.228 A 322 288 11 0 0 0 [[467, 745]] 1.0 6iup TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4XCUA 453 751 802.0 40M:61002 Type1.5_Back Inactive DFGin 5.265 13.642 BLAplus -110.08, 165.26 52.58, 39.15 -92.79, -5.77 54.37, 86.93 -89.94, -0.54 in-in in 8.22 Saltbr-in 3.44 HRD-in -58.72, -59.42 79.42, -2.24 in-out-out SNCioo out-out ActLoopNT-out 5.239 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.17, 166.24 APE9-dihe-in -114.18, 125.28 APE8-dihe-out -51.43, -25.8 APE8-rot-na 334.81 APE67-dihe-in -65.82, -4.36 -63.03, -21.58 APE12-dist-na 20.358 APE11-dist-na 20.901 APE10-dist-na 19.264 APE9-dist-out 11.155 L449M None None XRAY 1.71 0.196 0.243 A 300 287 3 0 0 0 [[467, 745]] 1.0 4xcu TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6NVGA 453 751 802.0 XL8:60804 Type1.5_Back Inactive DFGin 5.226 13.345 BLAplus -104.78, 161.09 56.06, 37.4 -85.63, -9.18 54.54, 85.27 -109.59, 3.52 in-in in 7.649 Saltbr-in 2.792 HRD-in -75.55, -55.06 84.65, -16.54 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.34 APE8-rot-na 33.55 APE67-dihe-in -70.37, -12.25 -60.57, -30.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.99 0.206 0.233 A 300 272 18 0 0 18 [[467, 745]] 1.0 6nvg TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6NVHA 453 750 802.0 XL6:60803 Type1.5_Back Inactive DFGin 5.245 13.401 BLAplus -105.65, 156.33 59.41, 40.23 -87.91, -7.9 56.0, 80.86 -110.13, 11.2 in-in in 7.645 Saltbr-in 2.909 HRD-in -72.21, -55.48 85.67, -17.85 in-out-out SNCioo out-out ActLoopNT-out 8.882 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.32 APE8-dihe-in -79.08, 68.56 APE8-rot-na 34.44 APE67-dihe-in -72.6, -11.42 -66.3, -25.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.092 None None None XRAY 1.9 0.213 0.234 A 300 271 18 0 0 15 [[467, 745]] 1.0 6nvh TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6NVIA 453 750 802.0 XL7:60801 Type1.5_Back Inactive DFGin 5.228 13.424 BLAplus -98.74, 158.44 61.07, 34.7 -84.24, 4.13 54.35, 83.32 -125.28, 10.73 in-in in 7.519 Saltbr-in 2.788 HRD-in -67.86, -63.14 93.89, -12.35 in-out-out SNCioo out-out ActLoopNT-out 10.808 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.76 APE8-dihe-in -79.66, 67.36 APE8-rot-na 35.8 APE67-dihe-in -54.63, -21.11 -49.95, -49.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.014 None None None XRAY 2.117 0.244 0.281 A 300 270 19 0 0 13 [[467, 745]] 1.0 6nvi TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6NVJA 453 751 802.0 XL5:60805 Type1.5_Back Inactive DFGin 5.156 13.428 BLAplus -115.45, 166.84 46.39, 45.37 -92.54, -5.84 62.78, 75.02 -111.78, 12.99 in-in in 7.739 Saltbr-in 3.035 HRD-in -74.22, -50.72 84.72, -17.15 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.29 APE8-rot-na 32.25 APE67-dihe-in -71.97, -10.77 -70.51, -33.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.225 0.271 A 300 270 20 0 0 18 [[467, 745]] 1.0 6nvj TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6NVKA 453 750 802.0 XL9:60804 Type1.5_Back Inactive DFGin 5.41 13.402 BLAplus -111.15, 166.43 49.96, 40.14 -90.15, -10.4 62.08, 83.95 -67.49, -62.92 in-in in 7.891 Saltbr-in 3.324 HRD-in -72.5, -53.93 83.1, -15.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.17 APE8-rot-na 32.94 APE67-dihe-in -75.58, -9.12 -59.15, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.216 0.266 A 300 268 21 0 0 18 [[467, 745]] 1.0 6nvk TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6V9CA 453 751 802.0 QS7:801 Type1.5_Back Inactive DFGin 5.704 13.207 BLAplus -115.43, 161.07 52.83, 42.01 -94.99, -8.85 55.26, 83.8 -80.51, -1.36 in-in in 7.358 Saltbr-in 2.846 HRD-in -65.42, -53.69 80.61, -8.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.47, 131.07 APE9-dihe-in -110.88, 96.52 APE8-dihe-out -54.06, -26.94 APE8-rot-na 330.97 APE67-dihe-in -67.11, -10.72 -50.75, -30.29 APE12-dist-na 20.679 APE11-dist-na 22.123 APE10-dist-na 18.004 APE9-dist-out 11.564 None None None XRAY 1.9 0.201 0.227 A 300 279 11 0 0 6 [[467, 745]] 1.0 6v9c TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7DTZA 453 751 802.0 HHL:801 Type1.5_Back Inactive DFGin 5.04 13.231 BLAplus -106.32, 155.01 52.81, 43.27 -81.9, -13.46 51.78, 85.83 -110.23, 20.15 in-in in 7.777 Saltbr-in 2.961 HRD-in -70.3, -51.75 81.02, -9.17 in-out-out SNCioo out-out ActLoopNT-out 8.43 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.5, 137.82 APE9-dihe-in -110.53, 91.62 APE8-dihe-out -56.53, -20.36 APE8-rot-na 332.34 APE67-dihe-in -73.0, -6.55 -63.9, -22.13 APE12-dist-na 19.346 APE11-dist-na 21.051 APE10-dist-na 16.99 APE9-dist-out 11.885 C477A,R664E None None XRAY 2.01 0.167 0.198 A 309 299 0 0 0 0 [[467, 745]] 1.0 7dtz TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
6JPEA 452 751 802.0 BYU:801 Type1.5_Back Inactive DFGin 5.247 13.463 BLAplus -103.06, 149.11 61.81, 37.94 -77.24, -14.19 46.99, 86.6 -117.47, 17.69 in-in in 7.709 Saltbr-in 2.711 HRD-in -73.19, -51.91 79.91, -9.36 in-out-out SNCioo out-out ActLoopNT-out 8.6 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.69, 142.25 APE9-dihe-in -110.48, 89.58 APE8-dihe-out -59.73, -20.88 APE8-rot-na 330.5 APE67-dihe-in -72.7, -3.42 -57.67, -24.83 APE12-dist-na 18.786 APE11-dist-na 20.785 APE10-dist-na 16.815 APE9-dist-out 12.016 C477A,R664E None None XRAY 1.601 0.153 0.183 A 311 298 2 0 0 0 [[467, 745]] 1.0 6jpe TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
5NWZB 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.486 13.417 BLAplus -113.86, 158.8 59.13, 38.36 -84.32, -23.92 49.52, 81.33 -128.83, 999.0 in-in in 8.122 Saltbr-in 3.391 HRD-in -56.44, -67.62 94.06, -17.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.23 APE9-dihe-in -80.83, 151.57 APE8-dihe-in -83.52, 61.94 APE8-rot-na 31.92 APE67-dihe-in -70.65, -15.95 -46.83, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.376 None None None XRAY 2.37 999.0 999.0 B 307 268 31 0 0 17 [[467, 745]] 1.0 5nwz TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7F3MA 453 753 802.0 GX3:801 Type1.5_Back Inactive DFGin 5.552 13.192 BLAplus -107.13, 152.62 56.03, 47.93 -89.2, -14.08 45.11, 81.2 -107.31, 16.55 in-in in 7.847 Saltbr-in 3.399 HRD-in -72.1, -48.45 71.34, -0.81 in-out-out SNCioo out-out ActLoopNT-out 8.396 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -87.64, 146.43 APE9-dihe-in -113.34, 91.66 APE8-dihe-out -53.3, -18.71 APE8-rot-na 332.63 APE67-dihe-in -75.11, -5.8 -67.3, -21.18 APE12-dist-na 18.089 APE11-dist-na 20.715 APE10-dist-na 17.043 APE9-dist-out 11.763 R664E None None XRAY 2.289 0.19 0.237 A 311 298 3 0 0 0 [[467, 745]] 1.0 7f3m TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7V29A 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.457 13.125 BLAplus -121.31, 170.65 56.14, 38.3 -89.91, -13.64 53.46, 82.04 -105.81, 18.85 in-in in 7.698 Saltbr-in 2.814 HRD-in -73.56, -51.53 78.84, -9.11 in-out-out SNCioo out-out ActLoopNT-out 8.507 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -95.33, 150.7 APE9-dihe-in -110.55, 91.7 APE8-dihe-out -59.49, -19.26 APE8-rot-na 334.55 APE67-dihe-in -66.16, -14.6 -59.54, -27.23 APE12-dist-na 16.202 APE11-dist-na 19.039 APE10-dist-na 15.973 APE9-dist-out 11.4 R664E None None XRAY 1.983 0.194 0.241 A 311 293 4 0 0 0 [[467, 745]] 1.0 7v29 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
7V29B 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.303 13.258 BLAplus -114.54, 165.88 57.72, 42.48 -96.03, -8.41 54.15, 80.06 -108.88, 26.62 in-in in 7.78 Saltbr-in 2.544 HRD-in -71.41, -53.8 82.9, -10.79 in-out-out SNCioo out-out ActLoopNT-out 8.487 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -86.98, 141.4 APE9-dihe-in -110.54, 96.59 APE8-dihe-out -61.83, -15.99 APE8-rot-na 335.67 APE67-dihe-in -71.36, -5.88 -59.93, -27.74 APE12-dist-na 17.378 APE11-dist-na 19.788 APE10-dist-na 16.401 APE9-dist-out 11.399 R664E None None XRAY 1.983 0.194 0.241 B 311 290 7 0 0 0 [[467, 745]] 1.0 7v29 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
8XLQA 453 751 802.0 A1LVQ:801 Type1.5_Back Inactive DFGin 5.464 13.025 BLAplus -110.49, 154.34 56.41, 53.19 -87.86, -15.94 35.15, 87.75 -151.42, 999.0 in-in in 7.658 Saltbr-in 3.254 HRD-in -77.24, -55.4 78.04, -11.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.75, 139.57 APE9-dihe-in -110.17, 94.87 APE8-dihe-out -60.19, -19.05 APE8-rot-na 334.14 APE67-dihe-in -73.66, -3.29 -59.9, -24.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.821 R664E None None XRAY 1.95 0.171 0.211 A 311 296 3 0 0 3 [[467, 745]] 1.0 8xlq TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4QQCA 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGin 5.379 13.294 BLAplus -105.5, 167.64 62.41, 26.27 -78.09, -25.76 56.21, 83.69 -101.85, 145.28 in-in in 8.066 Saltbr-in 3.212 HRD-in -73.92, -52.23 79.6, -15.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.52 APE8-dihe-out -46.45, -18.28 APE8-rot-na 329.31 APE67-dihe-in -73.13, -9.32 -59.41, -33.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.649 R664E None None XRAY 2.4 0.163 0.214 A 323 271 35 0 0 17 [[467, 745]] 1.0 4qqc TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
8KH9A 454 752 802.0 VVW:903 Type1 Inactive DFGin 5.628 13.229 BLBplus -116.73, 162.01 54.49, 42.82 -90.48, 158.22 47.04, 88.15 53.89, 22.89 in-in in 7.539 Saltbr-in 2.692 HRD-in -76.16, -55.94 82.55, -10.33 in-out-out SNCioo out-out ActLoopNT-out 8.722 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.55, 140.78 APE9-dihe-in -111.22, 92.1 APE8-dihe-out -57.69, -22.37 APE8-rot-na 333.28 APE67-dihe-in -71.01, -5.51 -56.46, -26.43 APE12-dist-na 20.313 APE11-dist-na 21.834 APE10-dist-na 17.588 APE9-dist-out 11.963 C477A,V550M,R664E None None XRAY 1.42 0.171 0.193 A 300 299 0 0 0 0 [[467, 745]] 1.0 8kh9 TYR_FGFR4_HUMAN TYR 6.3e-101 343.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
5NWZA 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.841 13.039 BLBplus -113.97, 156.19 61.74, 48.41 -92.8, 152.39 41.89, 84.86 -162.16, 999.0 in-out in 8.028 Saltbr-out 4.725 HRD-in -59.82, -67.76 95.11, -14.9 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.43 APE8-dihe-in -81.01, 64.72 APE8-rot-na 32.13 APE67-dihe-in -74.52, -12.37 -52.63, -35.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.975 None None None XRAY 2.37 999.0 999.0 A 307 271 28 0 0 18 [[467, 745]] 1.0 5nwz TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4TYEA 451 753 802.0 No_ligand No_ligand Inactive DFGin 5.829 12.58 None -91.65, -29.21 -103.02, 104.95 -71.18, -26.95 65.53, 79.96 94.73, -139.66 in-in in 8.267 Saltbr-in 2.614 HRD-out -120.78, 153.56 -67.42, -42.5 in-out-out SNCioo out-out ActLoopNT-out 8.384 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.01 APE8-dihe-in -80.96, 75.64 APE8-rot-na 33.57 APE67-dihe-in -64.71, -19.07 -60.12, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.188 None None None XRAY 2.8 0.227 0.278 A 311 292 11 0 0 7 [[467, 745]] 1.0 4tye TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
5XFJA 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.021 13.251 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.31 Saltbr-out 4.274 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311 266 32 0 0 17 [[467, 745]] 1.0 5xfj TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
5XFFA 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.251 13.8 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.907 Saltbr-in 3.562 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.541 V550L None None XRAY 2.7 0.27 0.32 A 311 269 29 0 0 17 [[467, 745]] 1.0 5xff TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
5JKGA 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.415 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.788 Saltbr-in 2.748 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.405 None None None XRAY 2.352 0.237 0.277 A 311 266 32 0 0 17 [[467, 745]] 1.0 5jkg TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4QQ5A 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGout 13.825 11.135 BBAminus -99.0, 166.33 -153.32, 109.28 -96.97, 16.74 304.57, 104.6 -130.76, 29.26 in-in in 7.846 Saltbr-in 2.905 HRD-in -72.86, -56.2 82.96, -11.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.0 APE8-dihe-out -47.81, -19.48 APE8-rot-na 326.35 APE67-dihe-in -66.59, -10.5 -64.2, -38.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.258 V550L,R664E None None XRAY 2.203 0.197 0.234 A 323 272 34 0 0 16 [[467, 745]] 1.0 4qq5 TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4R6VA 445 750 802.0 FI3:60801 Type1.5_Back Inactive DFGout 13.725 11.594 BBAminus -104.3, 160.0 -151.01, 100.96 -90.12, 14.65 307.32, 109.77 -121.7, 20.63 in-in in 7.979 Saltbr-in 2.852 HRD-in -75.49, -50.13 79.72, -18.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -44.34 APE8-rot-na 330.88 APE67-dihe-in -70.56, -4.7 -57.71, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V550L,R664E None None XRAY 2.353 0.179 0.227 A 323 271 35 0 0 17 [[467, 745]] 1.0 4r6v TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4UXQA 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.289 9.688 BBAminus -132.52, -175.6 -154.98, 108.32 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.813 Saltbr-in 2.727 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.227 APE11-dist-na 12.924 APE10-dist-na 10.113 APE9-dist-out 11.612 C477A None None XRAY 1.85 0.205 0.268 A 309 286 13 0 0 0 [[467, 745]] 1.0 4uxq TYR_FGFR4_HUMAN TYR 8.2e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4TYJA 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.602 BBAminus -136.8, -177.28 -149.4, 114.79 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.82 Saltbr-in 2.757 HRD-in -71.95, -55.51 84.74, -19.01 in-out-out SNCioo out-out ActLoopNT-out 19.108 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.819 None None None XRAY 2.45 0.217 0.247 A 311 275 32 0 0 15 [[467, 745]] 1.0 4tyj TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
4QRCA 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.848 9.448 None -128.93, 176.89 -168.87, 140.49 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.269 Saltbr-in 2.545 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.662 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.537 APE11-dist-na 21.047 APE10-dist-na 16.873 APE9-dist-out 12.017 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323 297 0 0 0 0 [[467, 745]] 1.0 4qrc TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
5NUDB 449 750 802.0 99K:60801 Type1 Inactive None 999.0 999.0 None -104.81, 161.89 46.27, 64.92 -114.7, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.34 Saltbr-in 2.809 HRD-in -51.67, -45.87 64.18, -17.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 126.54 APE9-dihe-in -104.07, 151.6 APE8-dihe-in -76.04, 73.43 APE8-rot-na 28.96 APE67-dihe-in -64.78, -21.38 -59.9, -33.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.406 None None None XRAY 2.5 999.0 999.0 B 307 270 32 0 0 18 [[467, 745]] 1.0 5nud TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

TYR_FGFR4 (Fibroblast growth factor receptor 4)

Total number of chains: 56
Active chains: 2
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 42 75.0% 8KH8A
DFGin None 4 7.1% 4TYEA
DFGout BBAminus 4 7.1% 4UXQA
DFGin BLAminus 2 3.6% AF-P22455-K1A
DFGin BLBplus 2 3.6% 8KH9A
DFGout None 1 1.8% 4QRCA
None None 1 1.8% 5NUDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR4_HUMAN AF-P22455-K1A P22455 459 753 802.0 No_ligand No_ligand Active DFGin 6.574 13.785 BLAminus -135.33, -173.77 55.98, 70.34 -87.24, 10.27 289.35, 94.13 -59.23, -30.92 in-in in 7.511 Saltbr-in 2.595 HRD-in -72.07, -43.39 66.46, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.926 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.52, 129.24 APE9-dihe-in -137.27, 151.64 APE8-dihe-in -78.22, 78.83 APE8-rot-na 36.58 APE67-dihe-in -65.35, -13.99 -47.37, -43.33 APE12-dist-na 14.384 APE11-dist-na 9.859 APE10-dist-na 10.001 APE9-dist-in 6.46 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[467, 745]] 1.0 AF-P22455-K1 Homo sapiens TYR_FGFR4_HUMAN TYR 1e-100 342.3 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN AF-P22455-K3A P22455 459 753 802.0 No_ligand No_ligand Active DFGin 6.149 13.447 BLAminus -140.69, -177.1 59.37, 67.02 -80.26, 11.26 289.47, 99.81 -58.5, -28.48 in-in in 7.979 Saltbr-in 2.661 HRD-in -82.71, -44.63 62.67, -5.09 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.76, 137.79 APE9-dihe-in -134.14, 131.39 APE8-dihe-in -83.17, 63.92 APE8-rot-na 35.81 APE67-dihe-in -68.87, -6.04 -46.28, -47.07 APE12-dist-na 13.462 APE11-dist-na 9.758 APE10-dist-na 8.185 APE9-dist-in 6.662 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[467, 745]] 1.0 AF-P22455-K3 Homo sapiens TYR_FGFR4_HUMAN TYR 1e-100 342.3 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4QQJA P22455 454 752 802.0 No_ligand No_ligand Inactive DFGin 5.518 13.246 BLAplus -118.0, 159.35 59.24, 32.52 -80.61, -12.66 51.69, 84.73 -110.12, 11.1 in-in in 7.686 Saltbr-in 2.81 HRD-in -72.5, -55.76 83.76, -10.09 in-out-out SNCioo out-out ActLoopNT-out 8.404 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -77.21, 142.6 APE9-dihe-in -111.29, 91.44 APE8-dihe-out -57.79, -24.74 APE8-rot-na 330.32 APE67-dihe-in -72.79, -4.34 -56.9, -23.16 APE12-dist-na 18.828 APE11-dist-na 20.839 APE10-dist-na 16.978 APE9-dist-out 11.757 C477A,V550L,R664E None None XRAY 1.682 0.195 0.22 A 323 282 17 0 0 0 [[467, 745]] 1.0 4qqj Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4QQTA P22455 454 750 802.0 No_ligand No_ligand Inactive DFGin 5.306 12.668 BLAplus -114.06, 158.28 58.5, 36.24 -80.5, -13.9 51.72, 86.53 -109.31, 19.2 in-in in 7.276 Saltbr-in 2.732 HRD-in -70.87, -53.69 82.76, -12.35 in-out-out SNCioo out-out ActLoopNT-out 8.155 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.24, 139.82 APE9-dihe-in -109.2, 91.15 APE8-dihe-out -56.36, -21.76 APE8-rot-na 332.77 APE67-dihe-in -69.44, -8.72 -57.84, -25.29 APE12-dist-na 19.372 APE11-dist-na 21.092 APE10-dist-na 17.099 APE9-dist-out 11.866 C477A,R664E None None XRAY 1.501 0.223 0.248 A 323 283 14 0 0 0 [[467, 745]] 1.0 4qqt Homo sapiens TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4TYGA P22455 447 751 802.0 No_ligand No_ligand Inactive DFGin 5.036 13.264 BLAplus -113.04, 168.56 59.21, 26.28 -74.51, -27.59 55.83, 78.88 -116.06, 38.07 in-in in 8.36 Saltbr-in 2.943 HRD-in -76.3, -50.92 72.53, 0.99 in-out-out SNCioo out-out ActLoopNT-out 9.589 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -69.06, 164.09 APE9-dihe-in -68.59, 127.31 APE8-dihe-in -75.26, 70.92 APE8-rot-na 33.17 APE67-dihe-in -73.51, -8.42 -61.75, -39.15 APE12-dist-na 16.414 APE11-dist-na 14.362 APE10-dist-na 17.016 APE9-dist-out 8.583 None None None XRAY 2.4 0.204 0.238 A 311 290 15 0 0 0 [[467, 745]] 1.0 4tyg Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7WCXA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.263 13.141 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.792 Saltbr-in 2.511 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.644 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.074 APE11-dist-na 20.85 APE10-dist-na 16.822 APE9-dist-out 11.904 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcx Homo sapiens TYR_FGFR4_HUMAN TYR 7e-101 342.8 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7YBXA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.487 13.153 BLAplus -117.55, 160.19 54.53, 49.02 -91.8, -26.59 44.5, 84.85 -106.57, 50.06 in-in in 7.559 Saltbr-in 2.569 HRD-in -80.18, -45.42 74.32, -9.85 in-out-out SNCioo out-out ActLoopNT-out 8.685 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.48, 136.62 APE9-dihe-in -109.39, 93.32 APE8-dihe-out -58.06, -17.41 APE8-rot-na 334.8 APE67-dihe-in -75.5, -1.38 -66.17, -23.12 APE12-dist-na 19.683 APE11-dist-na 21.389 APE10-dist-na 17.29 APE9-dist-out 11.925 V550M,R664E None None XRAY 2.233 0.182 0.22 A 309 300 0 0 0 0 [[467, 745]] 1.0 7ybx Homo sapiens TYR_FGFR4_HUMAN TYR 7e-101 342.8 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7WCWA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.839 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.582 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.633 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.435 APE11-dist-na 20.996 APE10-dist-na 16.929 APE9-dist-out 11.84 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcw Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7YBPA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.694 13.112 BLAplus -118.3, 157.64 52.77, 54.66 -79.94, -64.81 29.11, 91.47 -101.86, 63.71 in-in in 7.529 Saltbr-in 2.425 HRD-in -81.24, -48.67 73.48, -6.26 in-out-out SNCioo out-out ActLoopNT-out 8.825 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.22, 136.85 APE9-dihe-in -109.57, 90.67 APE8-dihe-out -55.15, -19.67 APE8-rot-na 333.84 APE67-dihe-in -75.88, -4.09 -65.13, -21.92 APE12-dist-na 20.005 APE11-dist-na 21.526 APE10-dist-na 17.387 APE9-dist-out 11.892 V550L,R664E None None XRAY 2.243 0.178 0.214 A 309 300 0 0 0 0 [[467, 745]] 1.0 7ybp Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 8KH8A P22455 453 751 802.0 VVW:802 Type1 Inactive DFGin 5.473 13.134 BLAplus -118.53, 158.78 61.66, 36.82 -83.32, -20.9 47.14, 88.2 -101.16, 42.7 in-in in 7.514 Saltbr-in 2.669 HRD-in -75.42, -56.09 83.49, -11.36 in-out-out SNCioo out-out ActLoopNT-out 8.748 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.21, 138.97 APE9-dihe-in -107.92, 92.76 APE8-dihe-out -57.64, -22.35 APE8-rot-na 332.41 APE67-dihe-in -70.15, -6.75 -57.07, -25.4 APE12-dist-na 19.944 APE11-dist-na 21.486 APE10-dist-na 17.34 APE9-dist-out 11.91 C477A,V550L,R664E None None XRAY 1.49 0.169 0.197 A 309 299 0 0 0 0 [[467, 745]] 1.0 8kh8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6JPJA P22455 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.658 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.247 Saltbr-in 2.318 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.002 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.294 APE11-dist-na 21.068 APE10-dist-na 17.129 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311 299 0 0 0 0 [[467, 745]] 1.0 6jpj Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 9K0IA P22455 453 752 802.0 A1EEW:801 Type1 Inactive DFGin 5.309 12.763 BLAplus -115.86, 158.69 55.98, 44.95 -85.41, -17.3 44.0, 85.95 -114.13, 46.58 in-out in 7.348 Saltbr-out 4.876 HRD-in -75.84, -47.79 74.65, -0.7 out-out-out SNCooo out-out ActLoopNT-out 8.556 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.32, 134.99 APE9-dihe-in -108.67, 92.7 APE8-dihe-out -58.49, -17.91 APE8-rot-na 335.2 APE67-dihe-in -74.49, -4.34 -64.54, -23.8 APE12-dist-na 19.445 APE11-dist-na 21.037 APE10-dist-na 16.938 APE9-dist-out 11.87 None None None XRAY 2.236 0.178 0.217 A 311 300 0 0 0 0 [[467, 745]] 1.0 9k0i Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 9K0JA P22455 453 752 802.0 A1EEX:801 Type1 Inactive DFGin 5.314 12.97 BLAplus -112.37, 155.75 53.23, 48.1 -84.71, -20.48 44.35, 88.64 -103.37, 33.18 in-in in 7.302 Saltbr-in 2.352 HRD-in -79.51, -52.63 79.39, -8.08 in-out-out SNCioo out-out ActLoopNT-out 8.618 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.26, 135.8 APE9-dihe-in -108.17, 93.1 APE8-dihe-out -57.75, -21.67 APE8-rot-na 334.34 APE67-dihe-in -72.28, -6.39 -60.48, -25.43 APE12-dist-na 19.657 APE11-dist-na 21.23 APE10-dist-na 17.112 APE9-dist-out 11.85 None None None XRAY 2.068 0.168 0.205 A 311 300 0 0 0 0 [[467, 745]] 1.0 9k0j Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 8W5CA P22455 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.074 12.626 BLAplus -113.45, 160.91 56.16, 49.61 -96.83, -7.74 55.25, 86.57 -110.59, 38.95 in-in in 7.449 Saltbr-in 2.888 HRD-in -80.69, -46.77 71.02, -3.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -45.86 APE8-dihe-in -77.5, 69.04 APE8-rot-na 31.31 APE67-dihe-in -69.88, -10.46 -68.35, -23.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.017 None None None XRAY 2.3 0.231 0.264 A 300 267 33 0 0 17 [[467, 745]] 1.0 8w5c Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 8W5CB P22455 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.119 12.687 BLAplus -112.49, 158.46 58.84, 48.55 -96.24, -11.93 55.51, 85.76 -106.62, 34.09 in-in in 7.515 Saltbr-in 2.715 HRD-in -78.98, -47.31 70.01, -1.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.73 APE8-dihe-in -76.63, 74.51 APE8-rot-na 30.6 APE67-dihe-in -68.94, -14.77 -70.82, -21.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.987 None None None XRAY 2.3 0.231 0.264 B 300 263 37 0 0 17 [[467, 745]] 1.0 8w5c Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7VJLA P22455 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.301 12.42 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.485 Saltbr-in 2.904 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301 263 37 0 0 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7VJLB P22455 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.405 13.204 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.876 Saltbr-in 2.665 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301 266 35 0 0 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6YI8A P22455 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.052 12.585 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.129 APE9-dist-out 9.562 None None None XRAY 2.13 0.198 0.231 A 307 277 24 0 0 15 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6YI8B P22455 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.551 13.074 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.399 Saltbr-in 2.814 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.081 None None None XRAY 2.13 0.198 0.231 B 307 270 32 0 0 18 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 5NUDA P22455 453 753 802.0 99K:60801 Type1 Inactive DFGin 5.601 13.131 BLAplus -103.97, 165.83 57.11, 38.22 -87.24, -12.04 51.74, 90.01 -124.91, 999.0 in-none in 7.746 Saltbr-none 999.0 HRD-in -60.07, -52.99 79.18, -24.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -112.95 APE9-dihe-in -78.26, 150.38 APE8-dihe-in -83.02, 51.4 APE8-rot-na 27.64 APE67-dihe-in -63.02, -12.3 -43.5, -50.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.744 None None None XRAY 2.5 999.0 999.0 A 307 267 34 0 0 17 [[467, 745]] 1.0 5nud Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4TYIA P22455 447 750 802.0 38O:60801 Type1 Inactive DFGin 5.017 12.757 BLAplus -124.41, 161.93 65.25, 9.26 -54.13, -39.53 65.77, 95.11 -82.78, -10.75 in-out in 7.441 Saltbr-out 5.518 HRD-out -72.43, 150.77 -73.64, -70.77 out-out-out SNCooo out-out ActLoopNT-out 8.032 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.18 APE8-dihe-in -82.6, 72.32 APE8-rot-na 33.83 APE67-dihe-in -58.23, -33.51 -75.34, -45.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.293 None None None XRAY 3.4 0.281 0.34 A 311 276 28 0 0 14 [[467, 745]] 1.0 4tyi Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7WCTA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.499 13.008 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.476 Saltbr-in 2.881 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.463 APE11-dist-na 21.045 APE10-dist-na 17.074 APE9-dist-out 11.772 R664E None None XRAY 2.106 0.184 0.217 A 311 300 0 0 0 0 [[467, 745]] 1.0 7wct Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7YBOA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.424 13.004 BLAplus -109.16, 160.64 54.99, 45.18 -87.51, -29.93 42.89, 87.09 -102.4, 91.8 in-in in 7.638 Saltbr-in 3.524 HRD-in -80.44, -50.18 72.25, -3.15 in-out-out SNCioo out-out ActLoopNT-out 8.547 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -92.41, 138.05 APE9-dihe-in -107.71, 88.36 APE8-dihe-out -54.72, -19.34 APE8-rot-na 336.83 APE67-dihe-in -77.24, 0.55 -64.65, -24.27 APE12-dist-na 18.682 APE11-dist-na 20.466 APE10-dist-na 16.682 APE9-dist-out 11.546 R664E None None XRAY 2.307 0.209 0.254 A 311 294 6 0 0 0 [[467, 745]] 1.0 7ybo Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7YC1A P22455 453 752 802.0 IIQ:801 Type1 Inactive DFGin 5.797 12.777 BLAplus -117.27, 155.16 56.14, 51.47 -92.56, -26.45 40.46, 83.33 -101.9, 30.14 in-in in 7.368 Saltbr-in 2.361 HRD-in -69.13, -51.39 74.34, -2.39 in-out-out SNCioo out-out ActLoopNT-out 8.434 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.9, 135.56 APE9-dihe-in -107.22, 92.14 APE8-dihe-out -55.34, -21.49 APE8-rot-na 335.34 APE67-dihe-in -73.76, 1.53 -66.5, -22.57 APE12-dist-na 19.984 APE11-dist-na 21.568 APE10-dist-na 17.463 APE9-dist-out 11.924 R664E None None XRAY 2.535 0.185 0.226 A 311 300 0 0 0 0 [[467, 745]] 1.0 7yc1 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7YC3A P22455 453 752 802.0 IIW:801 Type1 Inactive DFGin 5.327 12.527 BLAplus -110.77, 158.7 57.83, 39.6 -81.75, -23.54 48.21, 88.5 -97.33, 32.48 in-in in 7.226 Saltbr-in 2.622 HRD-in -77.12, -53.67 78.69, -9.75 in-out-out SNCioo out-out ActLoopNT-out 8.428 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.63, 139.81 APE9-dihe-in -109.42, 92.27 APE8-dihe-out -57.58, -22.6 APE8-rot-na 330.14 APE67-dihe-in -71.59, -6.73 -57.28, -26.46 APE12-dist-na 19.898 APE11-dist-na 21.507 APE10-dist-na 17.326 APE9-dist-out 11.9 R664E None None XRAY 1.987 0.163 0.196 A 311 300 0 0 0 0 [[467, 745]] 1.0 7yc3 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 8KH6A P22455 454 750 802.0 VVI:802 Type1 Inactive DFGin 5.815 12.912 BLAplus -119.68, 156.05 60.85, 41.93 -89.33, -24.21 45.12, 83.84 -107.44, 54.7 in-in in 7.349 Saltbr-in 2.208 HRD-in -74.63, -55.79 82.32, -9.59 in-out-out SNCioo out-out ActLoopNT-out 8.7 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.33, 136.78 APE9-dihe-in -108.3, 90.73 APE8-dihe-out -60.36, -21.53 APE8-rot-na 335.21 APE67-dihe-in -71.62, -5.23 -55.35, -27.56 APE12-dist-na 19.541 APE11-dist-na 21.277 APE10-dist-na 17.137 APE9-dist-out 11.92 R664E None None XRAY 1.62 0.205 0.228 A 311 289 8 0 0 0 [[467, 745]] 1.0 8kh6 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 8KH7A P22455 454 751 802.0 VVW:802 Type1 Inactive DFGin 5.276 12.722 BLAplus -115.76, 162.05 57.7, 35.04 -83.79, -12.86 51.09, 87.09 -105.89, 24.32 in-in in 7.417 Saltbr-in 2.782 HRD-in -69.92, -54.01 83.03, -10.74 in-out-out SNCioo out-out ActLoopNT-out 8.514 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -75.04, 139.88 APE9-dihe-in -109.97, 90.79 APE8-dihe-out -58.47, -20.09 APE8-rot-na 333.49 APE67-dihe-in -69.7, -7.45 -60.7, -23.51 APE12-dist-na 19.798 APE11-dist-na 21.421 APE10-dist-na 17.266 APE9-dist-out 11.991 R664E None None XRAY 1.52 0.166 0.195 A 311 290 8 0 0 0 [[467, 745]] 1.0 8kh7 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6IUOA P22455 445 750 802.0 AWX:60801 Type1 Inactive DFGin 5.154 13.899 BLAplus -116.17, 174.07 60.09, 13.1 -64.05, -29.8 62.3, 87.1 -83.94, 18.54 in-in in 8.028 Saltbr-in 2.999 HRD-in -65.57, -53.25 79.62, -17.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.56 APE8-dihe-out -49.41, -24.26 APE8-rot-na 19.79 APE67-dihe-in -70.32, -14.96 -48.88, -39.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.628 R664E None None XRAY 2.3 0.188 0.232 A 322 274 32 0 0 17 [[467, 745]] 1.0 6iuo Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6IUPA P22455 452 750 802.0 AX0:801 Type1 Inactive DFGin 5.074 13.526 BLAplus -116.15, 153.2 62.1, 31.67 -67.34, -18.6 49.7, 87.36 -110.99, 17.09 in-in in 8.124 Saltbr-in 2.77 HRD-in -75.32, -53.06 85.17, -10.28 in-out-out SNCioo out-out ActLoopNT-out 8.443 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.61, 140.51 APE9-dihe-in -109.08, 92.15 APE8-dihe-out -61.13, -19.99 APE8-rot-na 336.97 APE67-dihe-in -72.51, -7.5 -57.22, -22.29 APE12-dist-na 18.53 APE11-dist-na 20.71 APE10-dist-na 16.798 APE9-dist-out 11.949 R664E None None XRAY 2.0 0.172 0.228 A 322 288 11 0 0 0 [[467, 745]] 1.0 6iup Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4XCUA P22455 453 751 802.0 40M:61002 Type1.5_Back Inactive DFGin 5.265 13.642 BLAplus -110.08, 165.26 52.58, 39.15 -92.79, -5.77 54.37, 86.93 -89.94, -0.54 in-in in 8.22 Saltbr-in 3.44 HRD-in -58.72, -59.42 79.42, -2.24 in-out-out SNCioo out-out ActLoopNT-out 5.239 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.17, 166.24 APE9-dihe-in -114.18, 125.28 APE8-dihe-out -51.43, -25.8 APE8-rot-na 334.81 APE67-dihe-in -65.82, -4.36 -63.03, -21.58 APE12-dist-na 20.358 APE11-dist-na 20.901 APE10-dist-na 19.264 APE9-dist-out 11.155 L449M None None XRAY 1.71 0.196 0.243 A 300 287 3 0 0 0 [[467, 745]] 1.0 4xcu Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6NVGA P22455 453 751 802.0 XL8:60804 Type1.5_Back Inactive DFGin 5.226 13.345 BLAplus -104.78, 161.09 56.06, 37.4 -85.63, -9.18 54.54, 85.27 -109.59, 3.52 in-in in 7.649 Saltbr-in 2.792 HRD-in -75.55, -55.06 84.65, -16.54 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.34 APE8-rot-na 33.55 APE67-dihe-in -70.37, -12.25 -60.57, -30.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.99 0.206 0.233 A 300 272 18 0 0 18 [[467, 745]] 1.0 6nvg Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6NVHA P22455 453 750 802.0 XL6:60803 Type1.5_Back Inactive DFGin 5.245 13.401 BLAplus -105.65, 156.33 59.41, 40.23 -87.91, -7.9 56.0, 80.86 -110.13, 11.2 in-in in 7.645 Saltbr-in 2.909 HRD-in -72.21, -55.48 85.67, -17.85 in-out-out SNCioo out-out ActLoopNT-out 8.882 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.32 APE8-dihe-in -79.08, 68.56 APE8-rot-na 34.44 APE67-dihe-in -72.6, -11.42 -66.3, -25.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.092 None None None XRAY 1.9 0.213 0.234 A 300 271 18 0 0 15 [[467, 745]] 1.0 6nvh Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6NVIA P22455 453 750 802.0 XL7:60801 Type1.5_Back Inactive DFGin 5.228 13.424 BLAplus -98.74, 158.44 61.07, 34.7 -84.24, 4.13 54.35, 83.32 -125.28, 10.73 in-in in 7.519 Saltbr-in 2.788 HRD-in -67.86, -63.14 93.89, -12.35 in-out-out SNCioo out-out ActLoopNT-out 10.808 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.76 APE8-dihe-in -79.66, 67.36 APE8-rot-na 35.8 APE67-dihe-in -54.63, -21.11 -49.95, -49.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.014 None None None XRAY 2.117 0.244 0.281 A 300 270 19 0 0 13 [[467, 745]] 1.0 6nvi Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6NVJA P22455 453 751 802.0 XL5:60805 Type1.5_Back Inactive DFGin 5.156 13.428 BLAplus -115.45, 166.84 46.39, 45.37 -92.54, -5.84 62.78, 75.02 -111.78, 12.99 in-in in 7.739 Saltbr-in 3.035 HRD-in -74.22, -50.72 84.72, -17.15 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.29 APE8-rot-na 32.25 APE67-dihe-in -71.97, -10.77 -70.51, -33.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.225 0.271 A 300 270 20 0 0 18 [[467, 745]] 1.0 6nvj Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6NVKA P22455 453 750 802.0 XL9:60804 Type1.5_Back Inactive DFGin 5.41 13.402 BLAplus -111.15, 166.43 49.96, 40.14 -90.15, -10.4 62.08, 83.95 -67.49, -62.92 in-in in 7.891 Saltbr-in 3.324 HRD-in -72.5, -53.93 83.1, -15.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.17 APE8-rot-na 32.94 APE67-dihe-in -75.58, -9.12 -59.15, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.216 0.266 A 300 268 21 0 0 18 [[467, 745]] 1.0 6nvk Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6V9CA P22455 453 751 802.0 QS7:801 Type1.5_Back Inactive DFGin 5.704 13.207 BLAplus -115.43, 161.07 52.83, 42.01 -94.99, -8.85 55.26, 83.8 -80.51, -1.36 in-in in 7.358 Saltbr-in 2.846 HRD-in -65.42, -53.69 80.61, -8.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.47, 131.07 APE9-dihe-in -110.88, 96.52 APE8-dihe-out -54.06, -26.94 APE8-rot-na 330.97 APE67-dihe-in -67.11, -10.72 -50.75, -30.29 APE12-dist-na 20.679 APE11-dist-na 22.123 APE10-dist-na 18.004 APE9-dist-out 11.564 None None None XRAY 1.9 0.201 0.227 A 300 279 11 0 0 6 [[467, 745]] 1.0 6v9c Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7DTZA P22455 453 751 802.0 HHL:801 Type1.5_Back Inactive DFGin 5.04 13.231 BLAplus -106.32, 155.01 52.81, 43.27 -81.9, -13.46 51.78, 85.83 -110.23, 20.15 in-in in 7.777 Saltbr-in 2.961 HRD-in -70.3, -51.75 81.02, -9.17 in-out-out SNCioo out-out ActLoopNT-out 8.43 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.5, 137.82 APE9-dihe-in -110.53, 91.62 APE8-dihe-out -56.53, -20.36 APE8-rot-na 332.34 APE67-dihe-in -73.0, -6.55 -63.9, -22.13 APE12-dist-na 19.346 APE11-dist-na 21.051 APE10-dist-na 16.99 APE9-dist-out 11.885 C477A,R664E None None XRAY 2.01 0.167 0.198 A 309 299 0 0 0 0 [[467, 745]] 1.0 7dtz Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 6JPEA P22455 452 751 802.0 BYU:801 Type1.5_Back Inactive DFGin 5.247 13.463 BLAplus -103.06, 149.11 61.81, 37.94 -77.24, -14.19 46.99, 86.6 -117.47, 17.69 in-in in 7.709 Saltbr-in 2.711 HRD-in -73.19, -51.91 79.91, -9.36 in-out-out SNCioo out-out ActLoopNT-out 8.6 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.69, 142.25 APE9-dihe-in -110.48, 89.58 APE8-dihe-out -59.73, -20.88 APE8-rot-na 330.5 APE67-dihe-in -72.7, -3.42 -57.67, -24.83 APE12-dist-na 18.786 APE11-dist-na 20.785 APE10-dist-na 16.815 APE9-dist-out 12.016 C477A,R664E None None XRAY 1.601 0.153 0.183 A 311 298 2 0 0 0 [[467, 745]] 1.0 6jpe Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 5NWZB P22455 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.486 13.417 BLAplus -113.86, 158.8 59.13, 38.36 -84.32, -23.92 49.52, 81.33 -128.83, 999.0 in-in in 8.122 Saltbr-in 3.391 HRD-in -56.44, -67.62 94.06, -17.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.23 APE9-dihe-in -80.83, 151.57 APE8-dihe-in -83.52, 61.94 APE8-rot-na 31.92 APE67-dihe-in -70.65, -15.95 -46.83, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.376 None None None XRAY 2.37 999.0 999.0 B 307 268 31 0 0 17 [[467, 745]] 1.0 5nwz Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7F3MA P22455 453 753 802.0 GX3:801 Type1.5_Back Inactive DFGin 5.552 13.192 BLAplus -107.13, 152.62 56.03, 47.93 -89.2, -14.08 45.11, 81.2 -107.31, 16.55 in-in in 7.847 Saltbr-in 3.399 HRD-in -72.1, -48.45 71.34, -0.81 in-out-out SNCioo out-out ActLoopNT-out 8.396 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -87.64, 146.43 APE9-dihe-in -113.34, 91.66 APE8-dihe-out -53.3, -18.71 APE8-rot-na 332.63 APE67-dihe-in -75.11, -5.8 -67.3, -21.18 APE12-dist-na 18.089 APE11-dist-na 20.715 APE10-dist-na 17.043 APE9-dist-out 11.763 R664E None None XRAY 2.289 0.19 0.237 A 311 298 3 0 0 0 [[467, 745]] 1.0 7f3m Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7V29A P22455 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.457 13.125 BLAplus -121.31, 170.65 56.14, 38.3 -89.91, -13.64 53.46, 82.04 -105.81, 18.85 in-in in 7.698 Saltbr-in 2.814 HRD-in -73.56, -51.53 78.84, -9.11 in-out-out SNCioo out-out ActLoopNT-out 8.507 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -95.33, 150.7 APE9-dihe-in -110.55, 91.7 APE8-dihe-out -59.49, -19.26 APE8-rot-na 334.55 APE67-dihe-in -66.16, -14.6 -59.54, -27.23 APE12-dist-na 16.202 APE11-dist-na 19.039 APE10-dist-na 15.973 APE9-dist-out 11.4 R664E None None XRAY 1.983 0.194 0.241 A 311 293 4 0 0 0 [[467, 745]] 1.0 7v29 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 7V29B P22455 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.303 13.258 BLAplus -114.54, 165.88 57.72, 42.48 -96.03, -8.41 54.15, 80.06 -108.88, 26.62 in-in in 7.78 Saltbr-in 2.544 HRD-in -71.41, -53.8 82.9, -10.79 in-out-out SNCioo out-out ActLoopNT-out 8.487 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -86.98, 141.4 APE9-dihe-in -110.54, 96.59 APE8-dihe-out -61.83, -15.99 APE8-rot-na 335.67 APE67-dihe-in -71.36, -5.88 -59.93, -27.74 APE12-dist-na 17.378 APE11-dist-na 19.788 APE10-dist-na 16.401 APE9-dist-out 11.399 R664E None None XRAY 1.983 0.194 0.241 B 311 290 7 0 0 0 [[467, 745]] 1.0 7v29 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 8XLQA P22455 453 751 802.0 A1LVQ:801 Type1.5_Back Inactive DFGin 5.464 13.025 BLAplus -110.49, 154.34 56.41, 53.19 -87.86, -15.94 35.15, 87.75 -151.42, 999.0 in-in in 7.658 Saltbr-in 3.254 HRD-in -77.24, -55.4 78.04, -11.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.75, 139.57 APE9-dihe-in -110.17, 94.87 APE8-dihe-out -60.19, -19.05 APE8-rot-na 334.14 APE67-dihe-in -73.66, -3.29 -59.9, -24.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.821 R664E None None XRAY 1.95 0.171 0.211 A 311 296 3 0 0 3 [[467, 745]] 1.0 8xlq Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4QQCA P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGin 5.379 13.294 BLAplus -105.5, 167.64 62.41, 26.27 -78.09, -25.76 56.21, 83.69 -101.85, 145.28 in-in in 8.066 Saltbr-in 3.212 HRD-in -73.92, -52.23 79.6, -15.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.52 APE8-dihe-out -46.45, -18.28 APE8-rot-na 329.31 APE67-dihe-in -73.13, -9.32 -59.41, -33.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.649 R664E None None XRAY 2.4 0.163 0.214 A 323 271 35 0 0 17 [[467, 745]] 1.0 4qqc Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 8KH9A P22455 454 752 802.0 VVW:903 Type1 Inactive DFGin 5.628 13.229 BLBplus -116.73, 162.01 54.49, 42.82 -90.48, 158.22 47.04, 88.15 53.89, 22.89 in-in in 7.539 Saltbr-in 2.692 HRD-in -76.16, -55.94 82.55, -10.33 in-out-out SNCioo out-out ActLoopNT-out 8.722 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.55, 140.78 APE9-dihe-in -111.22, 92.1 APE8-dihe-out -57.69, -22.37 APE8-rot-na 333.28 APE67-dihe-in -71.01, -5.51 -56.46, -26.43 APE12-dist-na 20.313 APE11-dist-na 21.834 APE10-dist-na 17.588 APE9-dist-out 11.963 C477A,V550M,R664E None None XRAY 1.42 0.171 0.193 A 300 299 0 0 0 0 [[467, 745]] 1.0 8kh9 Homo sapiens TYR_FGFR4_HUMAN TYR 6.3e-101 343.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 5NWZA P22455 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.841 13.039 BLBplus -113.97, 156.19 61.74, 48.41 -92.8, 152.39 41.89, 84.86 -162.16, 999.0 in-out in 8.028 Saltbr-out 4.725 HRD-in -59.82, -67.76 95.11, -14.9 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.43 APE8-dihe-in -81.01, 64.72 APE8-rot-na 32.13 APE67-dihe-in -74.52, -12.37 -52.63, -35.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.975 None None None XRAY 2.37 999.0 999.0 A 307 271 28 0 0 18 [[467, 745]] 1.0 5nwz Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4TYEA P22455 451 753 802.0 No_ligand No_ligand Inactive DFGin 5.829 12.58 None -91.65, -29.21 -103.02, 104.95 -71.18, -26.95 65.53, 79.96 94.73, -139.66 in-in in 8.267 Saltbr-in 2.614 HRD-out -120.78, 153.56 -67.42, -42.5 in-out-out SNCioo out-out ActLoopNT-out 8.384 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.01 APE8-dihe-in -80.96, 75.64 APE8-rot-na 33.57 APE67-dihe-in -64.71, -19.07 -60.12, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.188 None None None XRAY 2.8 0.227 0.278 A 311 292 11 0 0 7 [[467, 745]] 1.0 4tye Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.021 13.251 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.31 Saltbr-out 4.274 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311 266 32 0 0 17 [[467, 745]] 1.0 5xfj Homo sapiens TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.251 13.8 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.907 Saltbr-in 3.562 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.541 V550L None None XRAY 2.7 0.27 0.32 A 311 269 29 0 0 17 [[467, 745]] 1.0 5xff Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.415 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.788 Saltbr-in 2.748 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.405 None None None XRAY 2.352 0.237 0.277 A 311 266 32 0 0 17 [[467, 745]] 1.0 5jkg Homo sapiens TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4QQ5A P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGout 13.825 11.135 BBAminus -99.0, 166.33 -153.32, 109.28 -96.97, 16.74 304.57, 104.6 -130.76, 29.26 in-in in 7.846 Saltbr-in 2.905 HRD-in -72.86, -56.2 82.96, -11.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.0 APE8-dihe-out -47.81, -19.48 APE8-rot-na 326.35 APE67-dihe-in -66.59, -10.5 -64.2, -38.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.258 V550L,R664E None None XRAY 2.203 0.197 0.234 A 323 272 34 0 0 16 [[467, 745]] 1.0 4qq5 Homo sapiens TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4R6VA P22455 445 750 802.0 FI3:60801 Type1.5_Back Inactive DFGout 13.725 11.594 BBAminus -104.3, 160.0 -151.01, 100.96 -90.12, 14.65 307.32, 109.77 -121.7, 20.63 in-in in 7.979 Saltbr-in 2.852 HRD-in -75.49, -50.13 79.72, -18.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -44.34 APE8-rot-na 330.88 APE67-dihe-in -70.56, -4.7 -57.71, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V550L,R664E None None XRAY 2.353 0.179 0.227 A 323 271 35 0 0 17 [[467, 745]] 1.0 4r6v Homo sapiens TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4UXQA P22455 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.289 9.688 BBAminus -132.52, -175.6 -154.98, 108.32 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.813 Saltbr-in 2.727 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.227 APE11-dist-na 12.924 APE10-dist-na 10.113 APE9-dist-out 11.612 C477A None None XRAY 1.85 0.205 0.268 A 309 286 13 0 0 0 [[467, 745]] 1.0 4uxq Homo sapiens TYR_FGFR4_HUMAN TYR 8.2e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4TYJA P22455 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.602 BBAminus -136.8, -177.28 -149.4, 114.79 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.82 Saltbr-in 2.757 HRD-in -71.95, -55.51 84.74, -19.01 in-out-out SNCioo out-out ActLoopNT-out 19.108 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.819 None None None XRAY 2.45 0.217 0.247 A 311 275 32 0 0 15 [[467, 745]] 1.0 4tyj Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 4QRCA P22455 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.848 9.448 None -128.93, 176.89 -168.87, 140.49 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.269 Saltbr-in 2.545 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.662 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.537 APE11-dist-na 21.047 APE10-dist-na 16.873 APE9-dist-out 12.017 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323 297 0 0 0 0 [[467, 745]] 1.0 4qrc Homo sapiens TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4_HUMAN 5NUDB P22455 449 750 802.0 99K:60801 Type1 Inactive None 999.0 999.0 None -104.81, 161.89 46.27, 64.92 -114.7, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.34 Saltbr-in 2.809 HRD-in -51.67, -45.87 64.18, -17.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 126.54 APE9-dihe-in -104.07, 151.6 APE8-dihe-in -76.04, 73.43 APE8-rot-na 28.96 APE67-dihe-in -64.78, -21.38 -59.9, -33.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.406 None None None XRAY 2.5 999.0 999.0 B 307 270 32 0 0 18 [[467, 745]] 1.0 5nud Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

TYR_FGFR4 (Fibroblast growth factor receptor 4)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name