TYR_FGFR4 (Fibroblast growth factor receptor 4)

Total number of chains: 56
Active chains: 2
Uniprot: FGFR4_HUMAN
Kinase Domain Residues: 467 - 745
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 42 75.0% 8KH8A
DFGin None 4 7.1% 4TYEA
DFGout BBAminus 4 7.1% 4UXQA
DFGin BLAminus 2 3.6% AF-P22455-K1A
DFGin BLBplus 2 3.6% 8KH9A
DFGout None 1 1.8% 4QRCA
None None 1 1.8% 5NUDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR4 AF-P22455-K1A P22455 459 753 802.0 No_ligand No_ligand Active DFGin 6.5736 13.7852 BLAminus -135.33, -173.77 55.98, 70.34 -87.24, 10.27 289.35, 94.13 -59.23, -30.92 in-in in 7.5108 Saltbr-in 2.5953 HRD-in -72.07, -43.39 66.46, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.9256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.52, 129.24 APE9-dihe-in -137.27, 151.64 APE8-dihe-in -78.22, 78.83 APE8-rot-na 36.58 APE67-dihe-in -65.35, -13.99 -47.37, -43.33 APE12-dist-na 14.3836 APE11-dist-na 9.8594 APE10-dist-na 10.0012 APE9-dist-in 6.4603 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[467, 745]] 1.0 AF-P22455-K1 TYR_FGFR4_HUMAN TYR 1e-100 342.3 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 AF-P22455-K3A P22455 459 753 802.0 No_ligand No_ligand Active DFGin 6.149 13.447 BLAminus -140.69, -177.1 59.37, 67.02 -80.26, 11.26 289.47, 99.81 -58.5, -28.48 in-in in 7.9794 Saltbr-in 2.6612 HRD-in -82.71, -44.63 62.67, -5.09 in-in-in SNCiii in-in ActLoopNT-in 2.9299 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.76, 137.79 APE9-dihe-in -134.14, 131.39 APE8-dihe-in -83.17, 63.92 APE8-rot-na 35.81 APE67-dihe-in -68.87, -6.04 -46.28, -47.07 APE12-dist-na 13.4616 APE11-dist-na 9.7578 APE10-dist-na 8.1847 APE9-dist-in 6.6618 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[467, 745]] 1.0 AF-P22455-K3 TYR_FGFR4_HUMAN TYR 1e-100 342.3 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4QQJA P22455 454 752 802.0 No_ligand No_ligand Inactive DFGin 5.5178 13.2456 BLAplus -118.0, 159.35 59.24, 32.52 -80.61, -12.66 51.69, 84.73 -110.12, 11.1 in-in in 7.6863 Saltbr-in 2.8101 HRD-in -72.5, -55.76 83.76, -10.09 in-out-out SNCioo out-out ActLoopNT-out 8.4044 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -77.21, 142.6 APE9-dihe-in -111.29, 91.44 APE8-dihe-out -57.79, -24.74 APE8-rot-na 330.32 APE67-dihe-in -72.79, -4.34 -56.9, -23.16 APE12-dist-na 18.8278 APE11-dist-na 20.8392 APE10-dist-na 16.9783 APE9-dist-out 11.7571 C477A,V550L,R664E None None XRAY 1.682 0.195 0.22 A 323.0 282.0 17 30 30 0 [[467, 745]] 1.0 4qqj TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4QQTA P22455 454 750 802.0 No_ligand No_ligand Inactive DFGin 5.3055 12.668 BLAplus -114.06, 158.28 58.5, 36.24 -80.5, -13.9 51.72, 86.53 -109.31, 19.2 in-in in 7.2758 Saltbr-in 2.7316 HRD-in -70.87, -53.69 82.76, -12.35 in-out-out SNCioo out-out ActLoopNT-out 8.1549 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.24, 139.82 APE9-dihe-in -109.2, 91.15 APE8-dihe-out -56.36, -21.76 APE8-rot-na 332.77 APE67-dihe-in -69.44, -8.72 -57.84, -25.29 APE12-dist-na 19.3716 APE11-dist-na 21.0921 APE10-dist-na 17.0986 APE9-dist-out 11.8664 C477A,R664E None None XRAY 1.501 0.223 0.248 A 323.0 283.0 14 30 30 0 [[467, 745]] 1.0 4qqt TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4TYGA P22455 447 751 802.0 No_ligand No_ligand Inactive DFGin 5.0364 13.2643 BLAplus -113.04, 168.56 59.21, 26.28 -74.51, -27.59 55.83, 78.88 -116.06, 38.07 in-in in 8.3604 Saltbr-in 2.9431 HRD-in -76.3, -50.92 72.53, 0.99 in-out-out SNCioo out-out ActLoopNT-out 9.5886 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -69.06, 164.09 APE9-dihe-in -68.59, 127.31 APE8-dihe-in -75.26, 70.92 APE8-rot-na 33.17 APE67-dihe-in -73.51, -8.42 -61.75, -39.15 APE12-dist-na 16.4144 APE11-dist-na 14.362 APE10-dist-na 17.0158 APE9-dist-out 8.5826 None None None XRAY 2.4 0.204 0.238 A 311.0 290.0 15 30 30 0 [[467, 745]] 1.0 4tyg TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7WCXA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.2632 13.1414 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.7923 Saltbr-in 2.5114 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.6444 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.0736 APE11-dist-na 20.85 APE10-dist-na 16.8219 APE9-dist-out 11.9043 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcx TYR_FGFR4_HUMAN TYR 7e-101 342.8 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7YBXA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.4873 13.1535 BLAplus -117.55, 160.19 54.53, 49.02 -91.8, -26.59 44.5, 84.85 -106.57, 50.06 in-in in 7.5589 Saltbr-in 2.5688 HRD-in -80.18, -45.42 74.32, -9.85 in-out-out SNCioo out-out ActLoopNT-out 8.6851 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.48, 136.62 APE9-dihe-in -109.39, 93.32 APE8-dihe-out -58.06, -17.41 APE8-rot-na 334.8 APE67-dihe-in -75.5, -1.38 -66.17, -23.12 APE12-dist-na 19.6829 APE11-dist-na 21.3888 APE10-dist-na 17.2899 APE9-dist-out 11.925 V550M,R664E None None XRAY 2.233 0.182 0.22 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7ybx TYR_FGFR4_HUMAN TYR 7e-101 342.8 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7WCWA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.8394 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.5817 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.6329 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.4349 APE11-dist-na 20.9958 APE10-dist-na 16.9286 APE9-dist-out 11.8399 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcw TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7YBPA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.6943 13.112 BLAplus -118.3, 157.64 52.77, 54.66 -79.94, -64.81 29.11, 91.47 -101.86, 63.71 in-in in 7.5294 Saltbr-in 2.4249 HRD-in -81.24, -48.67 73.48, -6.26 in-out-out SNCioo out-out ActLoopNT-out 8.8248 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.22, 136.85 APE9-dihe-in -109.57, 90.67 APE8-dihe-out -55.15, -19.67 APE8-rot-na 333.84 APE67-dihe-in -75.88, -4.09 -65.13, -21.92 APE12-dist-na 20.005 APE11-dist-na 21.5264 APE10-dist-na 17.3869 APE9-dist-out 11.8922 V550L,R664E None None XRAY 2.243 0.178 0.214 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7ybp TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 8KH8A P22455 453 751 802.0 VVW:802 Type1 Inactive DFGin 5.4727 13.1344 BLAplus -118.53, 158.78 61.66, 36.82 -83.32, -20.9 47.14, 88.2 -101.16, 42.7 in-in in 7.5141 Saltbr-in 2.6689 HRD-in -75.42, -56.09 83.49, -11.36 in-out-out SNCioo out-out ActLoopNT-out 8.7477 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.21, 138.97 APE9-dihe-in -107.92, 92.76 APE8-dihe-out -57.64, -22.35 APE8-rot-na 332.41 APE67-dihe-in -70.15, -6.75 -57.07, -25.4 APE12-dist-na 19.9437 APE11-dist-na 21.4858 APE10-dist-na 17.3401 APE9-dist-out 11.9102 C477A,V550L,R664E None None XRAY 1.49 0.169 0.197 A 309.0 299.0 0 30 30 0 [[467, 745]] 1.0 8kh8 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6JPJA P22455 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.6584 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.2473 Saltbr-in 2.3178 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.0019 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.2943 APE11-dist-na 21.0682 APE10-dist-na 17.1289 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311.0 299.0 0 30 30 0 [[467, 745]] 1.0 6jpj TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 9K0IA P22455 453 752 802.0 A1EEW:801 Type1 Inactive DFGin 5.309 12.7633 BLAplus -115.86, 158.69 55.98, 44.95 -85.41, -17.3 44.0, 85.95 -114.13, 46.58 in-out in 7.3477 Saltbr-out 4.8758 HRD-in -75.84, -47.79 74.65, -0.7 out-out-out SNCooo out-out ActLoopNT-out 8.5564 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.32, 134.99 APE9-dihe-in -108.67, 92.7 APE8-dihe-out -58.49, -17.91 APE8-rot-na 335.2 APE67-dihe-in -74.49, -4.34 -64.54, -23.8 APE12-dist-na 19.4446 APE11-dist-na 21.0366 APE10-dist-na 16.9379 APE9-dist-out 11.8701 None None None XRAY 2.236 0.178 0.217 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 9k0i TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 9K0JA P22455 453 752 802.0 A1EEX:801 Type1 Inactive DFGin 5.3142 12.9705 BLAplus -112.37, 155.75 53.23, 48.1 -84.71, -20.48 44.35, 88.64 -103.37, 33.18 in-in in 7.3016 Saltbr-in 2.3518 HRD-in -79.51, -52.63 79.39, -8.08 in-out-out SNCioo out-out ActLoopNT-out 8.6182 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.26, 135.8 APE9-dihe-in -108.17, 93.1 APE8-dihe-out -57.75, -21.67 APE8-rot-na 334.34 APE67-dihe-in -72.28, -6.39 -60.48, -25.43 APE12-dist-na 19.6566 APE11-dist-na 21.2296 APE10-dist-na 17.1123 APE9-dist-out 11.8497 None None None XRAY 2.068 0.168 0.205 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 9k0j TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 8W5CA P22455 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.0744 12.6264 BLAplus -113.45, 160.91 56.16, 49.61 -96.83, -7.74 55.25, 86.57 -110.59, 38.95 in-in in 7.4489 Saltbr-in 2.8875 HRD-in -80.69, -46.77 71.02, -3.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -45.86 APE8-dihe-in -77.5, 69.04 APE8-rot-na 31.31 APE67-dihe-in -69.88, -10.46 -68.35, -23.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0166 None None None XRAY 2.3 0.231 0.264 A 300.0 267.0 33 30 13 17 [[467, 745]] 1.0 8w5c TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 8W5CB P22455 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.1188 12.6869 BLAplus -112.49, 158.46 58.84, 48.55 -96.24, -11.93 55.51, 85.76 -106.62, 34.09 in-in in 7.5153 Saltbr-in 2.7151 HRD-in -78.98, -47.31 70.01, -1.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.73 APE8-dihe-in -76.63, 74.51 APE8-rot-na 30.6 APE67-dihe-in -68.94, -14.77 -70.82, -21.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.9867 None None None XRAY 2.3 0.231 0.264 B 300.0 263.0 37 30 13 17 [[467, 745]] 1.0 8w5c TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7VJLA P22455 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.3011 12.4196 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.4851 Saltbr-in 2.9035 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301.0 263.0 37 30 11 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7VJLB P22455 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.4049 13.2037 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.8757 Saltbr-in 2.6652 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301.0 266.0 35 30 11 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6YI8A P22455 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.0516 12.5848 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.1286 APE9-dist-out 9.5625 None None None XRAY 2.13 0.198 0.231 A 307.0 277.0 24 30 15 15 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6YI8B P22455 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.5513 13.0744 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.3993 Saltbr-in 2.8136 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0812 None None None XRAY 2.13 0.198 0.231 B 307.0 270.0 32 30 12 18 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 5NUDA P22455 453 753 802.0 99K:60801 Type1 Inactive DFGin 5.6006 13.1307 BLAplus -103.97, 165.83 57.11, 38.22 -87.24, -12.04 51.74, 90.01 -124.91, 999.0 in-none in 7.7464 Saltbr-none 999.0 HRD-in -60.07, -52.99 79.18, -24.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -112.95 APE9-dihe-in -78.26, 150.38 APE8-dihe-in -83.02, 51.4 APE8-rot-na 27.64 APE67-dihe-in -63.02, -12.3 -43.5, -50.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.744 None None None XRAY 2.5 999.0 999.0 A 307.0 267.0 34 30 13 17 [[467, 745]] 1.0 5nud TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4TYIA P22455 447 750 802.0 38O:60801 Type1 Inactive DFGin 5.0167 12.7565 BLAplus -124.41, 161.93 65.25, 9.26 -54.13, -39.53 65.77, 95.11 -82.78, -10.75 in-out in 7.4415 Saltbr-out 5.5181 HRD-out -72.43, 150.77 -73.64, -70.77 out-out-out SNCooo out-out ActLoopNT-out 8.0317 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.18 APE8-dihe-in -82.6, 72.32 APE8-rot-na 33.83 APE67-dihe-in -58.23, -33.51 -75.34, -45.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2926 None None None XRAY 3.4 0.281 0.34 A 311.0 276.0 28 30 16 14 [[467, 745]] 1.0 4tyi TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7WCTA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.4993 13.0077 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.4757 Saltbr-in 2.8808 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.4968 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.4627 APE11-dist-na 21.0452 APE10-dist-na 17.0744 APE9-dist-out 11.7717 R664E None None XRAY 2.106 0.184 0.217 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wct TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7YBOA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.4241 13.0038 BLAplus -109.16, 160.64 54.99, 45.18 -87.51, -29.93 42.89, 87.09 -102.4, 91.8 in-in in 7.6378 Saltbr-in 3.5242 HRD-in -80.44, -50.18 72.25, -3.15 in-out-out SNCioo out-out ActLoopNT-out 8.547 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -92.41, 138.05 APE9-dihe-in -107.71, 88.36 APE8-dihe-out -54.72, -19.34 APE8-rot-na 336.83 APE67-dihe-in -77.24, 0.55 -64.65, -24.27 APE12-dist-na 18.6819 APE11-dist-na 20.4659 APE10-dist-na 16.682 APE9-dist-out 11.5458 R664E None None XRAY 2.307 0.209 0.254 A 311.0 294.0 6 30 30 0 [[467, 745]] 1.0 7ybo TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7YC1A P22455 453 752 802.0 IIQ:801 Type1 Inactive DFGin 5.7966 12.7769 BLAplus -117.27, 155.16 56.14, 51.47 -92.56, -26.45 40.46, 83.33 -101.9, 30.14 in-in in 7.3679 Saltbr-in 2.3606 HRD-in -69.13, -51.39 74.34, -2.39 in-out-out SNCioo out-out ActLoopNT-out 8.4343 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.9, 135.56 APE9-dihe-in -107.22, 92.14 APE8-dihe-out -55.34, -21.49 APE8-rot-na 335.34 APE67-dihe-in -73.76, 1.53 -66.5, -22.57 APE12-dist-na 19.9838 APE11-dist-na 21.5683 APE10-dist-na 17.4629 APE9-dist-out 11.9241 R664E None None XRAY 2.535 0.185 0.226 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7yc1 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7YC3A P22455 453 752 802.0 IIW:801 Type1 Inactive DFGin 5.3266 12.5268 BLAplus -110.77, 158.7 57.83, 39.6 -81.75, -23.54 48.21, 88.5 -97.33, 32.48 in-in in 7.2262 Saltbr-in 2.6224 HRD-in -77.12, -53.67 78.69, -9.75 in-out-out SNCioo out-out ActLoopNT-out 8.4275 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.63, 139.81 APE9-dihe-in -109.42, 92.27 APE8-dihe-out -57.58, -22.6 APE8-rot-na 330.14 APE67-dihe-in -71.59, -6.73 -57.28, -26.46 APE12-dist-na 19.8981 APE11-dist-na 21.5073 APE10-dist-na 17.3261 APE9-dist-out 11.9005 R664E None None XRAY 1.987 0.163 0.196 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7yc3 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 8KH6A P22455 454 750 802.0 VVI:802 Type1 Inactive DFGin 5.8146 12.9125 BLAplus -119.68, 156.05 60.85, 41.93 -89.33, -24.21 45.12, 83.84 -107.44, 54.7 in-in in 7.3491 Saltbr-in 2.2082 HRD-in -74.63, -55.79 82.32, -9.59 in-out-out SNCioo out-out ActLoopNT-out 8.7001 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.33, 136.78 APE9-dihe-in -108.3, 90.73 APE8-dihe-out -60.36, -21.53 APE8-rot-na 335.21 APE67-dihe-in -71.62, -5.23 -55.35, -27.56 APE12-dist-na 19.541 APE11-dist-na 21.2767 APE10-dist-na 17.1367 APE9-dist-out 11.9198 R664E None None XRAY 1.62 0.205 0.228 A 311.0 289.0 8 30 30 0 [[467, 745]] 1.0 8kh6 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 8KH7A P22455 454 751 802.0 VVW:802 Type1 Inactive DFGin 5.2756 12.7215 BLAplus -115.76, 162.05 57.7, 35.04 -83.79, -12.86 51.09, 87.09 -105.89, 24.32 in-in in 7.4168 Saltbr-in 2.7818 HRD-in -69.92, -54.01 83.03, -10.74 in-out-out SNCioo out-out ActLoopNT-out 8.5138 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -75.04, 139.88 APE9-dihe-in -109.97, 90.79 APE8-dihe-out -58.47, -20.09 APE8-rot-na 333.49 APE67-dihe-in -69.7, -7.45 -60.7, -23.51 APE12-dist-na 19.7984 APE11-dist-na 21.4206 APE10-dist-na 17.2658 APE9-dist-out 11.9913 R664E None None XRAY 1.52 0.166 0.195 A 311.0 290.0 8 30 30 0 [[467, 745]] 1.0 8kh7 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6IUOA P22455 445 750 802.0 AWX:60801 Type1 Inactive DFGin 5.1536 13.8985 BLAplus -116.17, 174.07 60.09, 13.1 -64.05, -29.8 62.3, 87.1 -83.94, 18.54 in-in in 8.0277 Saltbr-in 2.9987 HRD-in -65.57, -53.25 79.62, -17.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.56 APE8-dihe-out -49.41, -24.26 APE8-rot-na 19.79 APE67-dihe-in -70.32, -14.96 -48.88, -39.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.6282 R664E None None XRAY 2.3 0.188 0.232 A 322.0 274.0 32 30 13 17 [[467, 745]] 1.0 6iuo TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6IUPA P22455 452 750 802.0 AX0:801 Type1 Inactive DFGin 5.074 13.5259 BLAplus -116.15, 153.2 62.1, 31.67 -67.34, -18.6 49.7, 87.36 -110.99, 17.09 in-in in 8.1239 Saltbr-in 2.7702 HRD-in -75.32, -53.06 85.17, -10.28 in-out-out SNCioo out-out ActLoopNT-out 8.4425 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.61, 140.51 APE9-dihe-in -109.08, 92.15 APE8-dihe-out -61.13, -19.99 APE8-rot-na 336.97 APE67-dihe-in -72.51, -7.5 -57.22, -22.29 APE12-dist-na 18.5305 APE11-dist-na 20.7096 APE10-dist-na 16.798 APE9-dist-out 11.9489 R664E None None XRAY 2.0 0.172 0.228 A 322.0 288.0 11 30 30 0 [[467, 745]] 1.0 6iup TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4XCUA P22455 453 751 802.0 40M:61002 Type1.5_Back Inactive DFGin 5.265 13.6418 BLAplus -110.08, 165.26 52.58, 39.15 -92.79, -5.77 54.37, 86.93 -89.94, -0.54 in-in in 8.2197 Saltbr-in 3.4401 HRD-in -58.72, -59.42 79.42, -2.24 in-out-out SNCioo out-out ActLoopNT-out 5.239 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.17, 166.24 APE9-dihe-in -114.18, 125.28 APE8-dihe-out -51.43, -25.8 APE8-rot-na 334.81 APE67-dihe-in -65.82, -4.36 -63.03, -21.58 APE12-dist-na 20.3582 APE11-dist-na 20.9011 APE10-dist-na 19.2643 APE9-dist-out 11.1555 L449M None None XRAY 1.71 0.196 0.243 A 300.0 287.0 3 30 30 0 [[467, 745]] 1.0 4xcu TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6NVGA P22455 453 751 802.0 XL8:60804 Type1.5_Back Inactive DFGin 5.2263 13.3448 BLAplus -104.78, 161.09 56.06, 37.4 -85.63, -9.18 54.54, 85.27 -109.59, 3.52 in-in in 7.6492 Saltbr-in 2.7916 HRD-in -75.55, -55.06 84.65, -16.54 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.34 APE8-rot-na 33.55 APE67-dihe-in -70.37, -12.25 -60.57, -30.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.99 0.206 0.233 A 300.0 272.0 18 30 12 18 [[467, 745]] 1.0 6nvg TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6NVHA P22455 453 750 802.0 XL6:60803 Type1.5_Back Inactive DFGin 5.2448 13.4006 BLAplus -105.65, 156.33 59.41, 40.23 -87.91, -7.9 56.0, 80.86 -110.13, 11.2 in-in in 7.6449 Saltbr-in 2.9087 HRD-in -72.21, -55.48 85.67, -17.85 in-out-out SNCioo out-out ActLoopNT-out 8.8817 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.32 APE8-dihe-in -79.08, 68.56 APE8-rot-na 34.44 APE67-dihe-in -72.6, -11.42 -66.3, -25.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0923 None None None XRAY 1.9 0.213 0.234 A 300.0 271.0 18 30 15 15 [[467, 745]] 1.0 6nvh TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6NVIA P22455 453 750 802.0 XL7:60801 Type1.5_Back Inactive DFGin 5.2279 13.424 BLAplus -98.74, 158.44 61.07, 34.7 -84.24, 4.13 54.35, 83.32 -125.28, 10.73 in-in in 7.5195 Saltbr-in 2.7875 HRD-in -67.86, -63.14 93.89, -12.35 in-out-out SNCioo out-out ActLoopNT-out 10.8082 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.76 APE8-dihe-in -79.66, 67.36 APE8-rot-na 35.8 APE67-dihe-in -54.63, -21.11 -49.95, -49.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0138 None None None XRAY 2.117 0.244 0.281 A 300.0 270.0 19 30 17 13 [[467, 745]] 1.0 6nvi TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6NVJA P22455 453 751 802.0 XL5:60805 Type1.5_Back Inactive DFGin 5.1556 13.4282 BLAplus -115.45, 166.84 46.39, 45.37 -92.54, -5.84 62.78, 75.02 -111.78, 12.99 in-in in 7.7389 Saltbr-in 3.0352 HRD-in -74.22, -50.72 84.72, -17.15 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.29 APE8-rot-na 32.25 APE67-dihe-in -71.97, -10.77 -70.51, -33.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.225 0.271 A 300.0 270.0 20 30 12 18 [[467, 745]] 1.0 6nvj TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6NVKA P22455 453 750 802.0 XL9:60804 Type1.5_Back Inactive DFGin 5.4097 13.4021 BLAplus -111.15, 166.43 49.96, 40.14 -90.15, -10.4 62.08, 83.95 -67.49, -62.92 in-in in 7.8908 Saltbr-in 3.324 HRD-in -72.5, -53.93 83.1, -15.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.17 APE8-rot-na 32.94 APE67-dihe-in -75.58, -9.12 -59.15, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.216 0.266 A 300.0 268.0 21 30 12 18 [[467, 745]] 1.0 6nvk TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6V9CA P22455 453 751 802.0 QS7:801 Type1.5_Back Inactive DFGin 5.7038 13.2065 BLAplus -115.43, 161.07 52.83, 42.01 -94.99, -8.85 55.26, 83.8 -80.51, -1.36 in-in in 7.3577 Saltbr-in 2.8459 HRD-in -65.42, -53.69 80.61, -8.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.47, 131.07 APE9-dihe-in -110.88, 96.52 APE8-dihe-out -54.06, -26.94 APE8-rot-na 330.97 APE67-dihe-in -67.11, -10.72 -50.75, -30.29 APE12-dist-na 20.6793 APE11-dist-na 22.1231 APE10-dist-na 18.0039 APE9-dist-out 11.5642 None None None XRAY 1.9 0.201 0.227 A 300.0 279.0 11 30 24 6 [[467, 745]] 1.0 6v9c TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7DTZA P22455 453 751 802.0 HHL:801 Type1.5_Back Inactive DFGin 5.0405 13.2312 BLAplus -106.32, 155.01 52.81, 43.27 -81.9, -13.46 51.78, 85.83 -110.23, 20.15 in-in in 7.7767 Saltbr-in 2.9612 HRD-in -70.3, -51.75 81.02, -9.17 in-out-out SNCioo out-out ActLoopNT-out 8.4301 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.5, 137.82 APE9-dihe-in -110.53, 91.62 APE8-dihe-out -56.53, -20.36 APE8-rot-na 332.34 APE67-dihe-in -73.0, -6.55 -63.9, -22.13 APE12-dist-na 19.3461 APE11-dist-na 21.0511 APE10-dist-na 16.9904 APE9-dist-out 11.8846 C477A,R664E None None XRAY 2.01 0.167 0.198 A 309.0 299.0 0 30 30 0 [[467, 745]] 1.0 7dtz TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 6JPEA P22455 452 751 802.0 BYU:801 Type1.5_Back Inactive DFGin 5.2472 13.463 BLAplus -103.06, 149.11 61.81, 37.94 -77.24, -14.19 46.99, 86.6 -117.47, 17.69 in-in in 7.709 Saltbr-in 2.7112 HRD-in -73.19, -51.91 79.91, -9.36 in-out-out SNCioo out-out ActLoopNT-out 8.5997 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.69, 142.25 APE9-dihe-in -110.48, 89.58 APE8-dihe-out -59.73, -20.88 APE8-rot-na 330.5 APE67-dihe-in -72.7, -3.42 -57.67, -24.83 APE12-dist-na 18.7859 APE11-dist-na 20.7845 APE10-dist-na 16.8151 APE9-dist-out 12.016 C477A,R664E None None XRAY 1.601 0.153 0.183 A 311.0 298.0 2 30 30 0 [[467, 745]] 1.0 6jpe TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 5NWZB P22455 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.4857 13.4174 BLAplus -113.86, 158.8 59.13, 38.36 -84.32, -23.92 49.52, 81.33 -128.83, 999.0 in-in in 8.1221 Saltbr-in 3.3914 HRD-in -56.44, -67.62 94.06, -17.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.23 APE9-dihe-in -80.83, 151.57 APE8-dihe-in -83.52, 61.94 APE8-rot-na 31.92 APE67-dihe-in -70.65, -15.95 -46.83, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3756 None None None XRAY 2.37 999.0 999.0 B 307.0 268.0 31 30 13 17 [[467, 745]] 1.0 5nwz TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7F3MA P22455 453 753 802.0 GX3:801 Type1.5_Back Inactive DFGin 5.5524 13.1922 BLAplus -107.13, 152.62 56.03, 47.93 -89.2, -14.08 45.11, 81.2 -107.31, 16.55 in-in in 7.847 Saltbr-in 3.3992 HRD-in -72.1, -48.45 71.34, -0.81 in-out-out SNCioo out-out ActLoopNT-out 8.396 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -87.64, 146.43 APE9-dihe-in -113.34, 91.66 APE8-dihe-out -53.3, -18.71 APE8-rot-na 332.63 APE67-dihe-in -75.11, -5.8 -67.3, -21.18 APE12-dist-na 18.0889 APE11-dist-na 20.7152 APE10-dist-na 17.0429 APE9-dist-out 11.763 R664E None None XRAY 2.289 0.19 0.237 A 311.0 298.0 3 30 30 0 [[467, 745]] 1.0 7f3m TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7V29A P22455 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.457 13.1251 BLAplus -121.31, 170.65 56.14, 38.3 -89.91, -13.64 53.46, 82.04 -105.81, 18.85 in-in in 7.6976 Saltbr-in 2.8139 HRD-in -73.56, -51.53 78.84, -9.11 in-out-out SNCioo out-out ActLoopNT-out 8.5074 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -95.33, 150.7 APE9-dihe-in -110.55, 91.7 APE8-dihe-out -59.49, -19.26 APE8-rot-na 334.55 APE67-dihe-in -66.16, -14.6 -59.54, -27.23 APE12-dist-na 16.2016 APE11-dist-na 19.0391 APE10-dist-na 15.9727 APE9-dist-out 11.4004 R664E None None XRAY 1.983 0.194 0.241 A 311.0 293.0 4 30 30 0 [[467, 745]] 1.0 7v29 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 7V29B P22455 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.303 13.2578 BLAplus -114.54, 165.88 57.72, 42.48 -96.03, -8.41 54.15, 80.06 -108.88, 26.62 in-in in 7.7796 Saltbr-in 2.5444 HRD-in -71.41, -53.8 82.9, -10.79 in-out-out SNCioo out-out ActLoopNT-out 8.4868 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -86.98, 141.4 APE9-dihe-in -110.54, 96.59 APE8-dihe-out -61.83, -15.99 APE8-rot-na 335.67 APE67-dihe-in -71.36, -5.88 -59.93, -27.74 APE12-dist-na 17.3778 APE11-dist-na 19.7882 APE10-dist-na 16.4005 APE9-dist-out 11.3985 R664E None None XRAY 1.983 0.194 0.241 B 311.0 290.0 7 30 30 0 [[467, 745]] 1.0 7v29 TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 8XLQA P22455 453 751 802.0 A1LVQ:801 Type1.5_Back Inactive DFGin 5.4641 13.0254 BLAplus -110.49, 154.34 56.41, 53.19 -87.86, -15.94 35.15, 87.75 -151.42, 999.0 in-in in 7.6576 Saltbr-in 3.2542 HRD-in -77.24, -55.4 78.04, -11.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.75, 139.57 APE9-dihe-in -110.17, 94.87 APE8-dihe-out -60.19, -19.05 APE8-rot-na 334.14 APE67-dihe-in -73.66, -3.29 -59.9, -24.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8209 R664E None None XRAY 1.95 0.171 0.211 A 311.0 296.0 3 30 27 3 [[467, 745]] 1.0 8xlq TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4QQCA P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGin 5.3786 13.2944 BLAplus -105.5, 167.64 62.41, 26.27 -78.09, -25.76 56.21, 83.69 -101.85, 145.28 in-in in 8.0664 Saltbr-in 3.2123 HRD-in -73.92, -52.23 79.6, -15.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.52 APE8-dihe-out -46.45, -18.28 APE8-rot-na 329.31 APE67-dihe-in -73.13, -9.32 -59.41, -33.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.649 R664E None None XRAY 2.4 0.163 0.214 A 323.0 271.0 35 30 13 17 [[467, 745]] 1.0 4qqc TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 8KH9A P22455 454 752 802.0 VVW:903 Type1 Inactive DFGin 5.6284 13.2287 BLBplus -116.73, 162.01 54.49, 42.82 -90.48, 158.22 47.04, 88.15 53.89, 22.89 in-in in 7.5394 Saltbr-in 2.6915 HRD-in -76.16, -55.94 82.55, -10.33 in-out-out SNCioo out-out ActLoopNT-out 8.7222 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.55, 140.78 APE9-dihe-in -111.22, 92.1 APE8-dihe-out -57.69, -22.37 APE8-rot-na 333.28 APE67-dihe-in -71.01, -5.51 -56.46, -26.43 APE12-dist-na 20.3132 APE11-dist-na 21.8343 APE10-dist-na 17.5883 APE9-dist-out 11.963 C477A,V550M,R664E None None XRAY 1.42 0.171 0.193 A 300.0 299.0 0 30 30 0 [[467, 745]] 1.0 8kh9 TYR_FGFR4_HUMAN TYR 6.3e-101 343.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 5NWZA P22455 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.8412 13.0386 BLBplus -113.97, 156.19 61.74, 48.41 -92.8, 152.39 41.89, 84.86 -162.16, 999.0 in-out in 8.0285 Saltbr-out 4.725 HRD-in -59.82, -67.76 95.11, -14.9 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.43 APE8-dihe-in -81.01, 64.72 APE8-rot-na 32.13 APE67-dihe-in -74.52, -12.37 -52.63, -35.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9747 None None None XRAY 2.37 999.0 999.0 A 307.0 271.0 28 30 12 18 [[467, 745]] 1.0 5nwz TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4TYEA P22455 451 753 802.0 No_ligand No_ligand Inactive DFGin 5.829 12.5802 None -91.65, -29.21 -103.02, 104.95 -71.18, -26.95 65.53, 79.96 94.73, -139.66 in-in in 8.2669 Saltbr-in 2.6135 HRD-out -120.78, 153.56 -67.42, -42.5 in-out-out SNCioo out-out ActLoopNT-out 8.3844 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.01 APE8-dihe-in -80.96, 75.64 APE8-rot-na 33.57 APE67-dihe-in -64.71, -19.07 -60.12, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1877 None None None XRAY 2.8 0.227 0.278 A 311.0 292.0 11 30 23 7 [[467, 745]] 1.0 4tye TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.0214 13.2508 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.3097 Saltbr-out 4.2744 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5xfj TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.2509 13.8003 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.9065 Saltbr-in 3.5618 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.5407 V550L None None XRAY 2.7 0.27 0.32 A 311.0 269.0 29 30 13 17 [[467, 745]] 1.0 5xff TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.4149 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.7877 Saltbr-in 2.7483 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4055 None None None XRAY 2.352 0.237 0.277 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5jkg TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4QQ5A P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGout 13.8248 11.1354 BBAminus -99.0, 166.33 -153.32, 109.28 -96.97, 16.74 304.57, 104.6 -130.76, 29.26 in-in in 7.8461 Saltbr-in 2.9055 HRD-in -72.86, -56.2 82.96, -11.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.0 APE8-dihe-out -47.81, -19.48 APE8-rot-na 326.35 APE67-dihe-in -66.59, -10.5 -64.2, -38.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2578 V550L,R664E None None XRAY 2.203 0.197 0.234 A 323.0 272.0 34 30 14 16 [[467, 745]] 1.0 4qq5 TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4R6VA P22455 445 750 802.0 FI3:60801 Type1.5_Back Inactive DFGout 13.7251 11.5939 BBAminus -104.3, 160.0 -151.01, 100.96 -90.12, 14.65 307.32, 109.77 -121.7, 20.63 in-in in 7.9792 Saltbr-in 2.8524 HRD-in -75.49, -50.13 79.72, -18.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -44.34 APE8-rot-na 330.88 APE67-dihe-in -70.56, -4.7 -57.71, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V550L,R664E None None XRAY 2.353 0.179 0.227 A 323.0 271.0 35 30 13 17 [[467, 745]] 1.0 4r6v TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4UXQA P22455 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.2886 9.6881 BBAminus -132.52, -175.6 -154.98, 108.32 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.8131 Saltbr-in 2.7274 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.2275 APE11-dist-na 12.9237 APE10-dist-na 10.1127 APE9-dist-out 11.6116 C477A None None XRAY 1.85 0.205 0.268 A 309.0 286.0 13 30 30 0 [[467, 745]] 1.0 4uxq TYR_FGFR4_HUMAN TYR 8.2e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4TYJA P22455 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.6017 BBAminus -136.8, -177.28 -149.4, 114.79 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.8197 Saltbr-in 2.7569 HRD-in -71.95, -55.51 84.74, -19.01 in-out-out SNCioo out-out ActLoopNT-out 19.1078 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8188 None None None XRAY 2.45 0.217 0.247 A 311.0 275.0 32 30 15 15 [[467, 745]] 1.0 4tyj TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 4QRCA P22455 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.8479 9.4478 None -128.93, 176.89 -168.87, 140.49 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.2685 Saltbr-in 2.5447 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.6625 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.5374 APE11-dist-na 21.0468 APE10-dist-na 16.8729 APE9-dist-out 12.0169 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323.0 297.0 0 30 30 0 [[467, 745]] 1.0 4qrc TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 5NUDB P22455 449 750 802.0 99K:60801 Type1 Inactive None 999.0 999.0 None -104.81, 161.89 46.27, 64.92 -114.7, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.3398 Saltbr-in 2.8094 HRD-in -51.67, -45.87 64.18, -17.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 126.54 APE9-dihe-in -104.07, 151.6 APE8-dihe-in -76.04, 73.43 APE8-rot-na 28.96 APE67-dihe-in -64.78, -21.38 -59.9, -33.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4064 None None None XRAY 2.5 999.0 999.0 B 307.0 270.0 32 30 12 18 [[467, 745]] 1.0 5nud TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

TYR_FGFR4 (Fibroblast growth factor receptor 4)

Total number of chains: 56
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 42 75.0% 8KH8A
DFGin None 4 7.1% 4TYEA
DFGout BBAminus 4 7.1% 4UXQA
DFGin BLAminus 2 3.6% AF-P22455-K1A
DFGin BLBplus 2 3.6% 8KH9A
DFGout None 1 1.8% 4QRCA
None None 1 1.8% 5NUDB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR4 FGFR4_HUMAN AF-P22455-K1A P22455 459 753 802.0 No_ligand No_ligand Active DFGin 6.5736 13.7852 BLAminus -135.33, -173.77 55.98, 70.34 -87.24, 10.27 289.35, 94.13 -59.23, -30.92 in-in in 7.5108 Saltbr-in 2.5953 HRD-in -72.07, -43.39 66.46, -16.93 in-in-in SNCiii in-in ActLoopNT-in 2.9256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -62.52, 129.24 APE9-dihe-in -137.27, 151.64 APE8-dihe-in -78.22, 78.83 APE8-rot-na 36.58 APE67-dihe-in -65.35, -13.99 -47.37, -43.33 APE12-dist-na 14.3836 APE11-dist-na 9.8594 APE10-dist-na 10.0012 APE9-dist-in 6.4603 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[467, 745]] 1.0 AF-P22455-K1 Homo sapiens TYR_FGFR4_HUMAN TYR 1e-100 342.3 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN AF-P22455-K3A P22455 459 753 802.0 No_ligand No_ligand Active DFGin 6.149 13.447 BLAminus -140.69, -177.1 59.37, 67.02 -80.26, 11.26 289.47, 99.81 -58.5, -28.48 in-in in 7.9794 Saltbr-in 2.6612 HRD-in -82.71, -44.63 62.67, -5.09 in-in-in SNCiii in-in ActLoopNT-in 2.9299 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.76, 137.79 APE9-dihe-in -134.14, 131.39 APE8-dihe-in -83.17, 63.92 APE8-rot-na 35.81 APE67-dihe-in -68.87, -6.04 -46.28, -47.07 APE12-dist-na 13.4616 APE11-dist-na 9.7578 APE10-dist-na 8.1847 APE9-dist-in 6.6618 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[467, 745]] 1.0 AF-P22455-K3 Homo sapiens TYR_FGFR4_HUMAN TYR 1e-100 342.3 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4QQJA P22455 454 752 802.0 No_ligand No_ligand Inactive DFGin 5.5178 13.2456 BLAplus -118.0, 159.35 59.24, 32.52 -80.61, -12.66 51.69, 84.73 -110.12, 11.1 in-in in 7.6863 Saltbr-in 2.8101 HRD-in -72.5, -55.76 83.76, -10.09 in-out-out SNCioo out-out ActLoopNT-out 8.4044 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -77.21, 142.6 APE9-dihe-in -111.29, 91.44 APE8-dihe-out -57.79, -24.74 APE8-rot-na 330.32 APE67-dihe-in -72.79, -4.34 -56.9, -23.16 APE12-dist-na 18.8278 APE11-dist-na 20.8392 APE10-dist-na 16.9783 APE9-dist-out 11.7571 C477A,V550L,R664E None None XRAY 1.682 0.195 0.22 A 323.0 282.0 17 30 30 0 [[467, 745]] 1.0 4qqj Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4QQTA P22455 454 750 802.0 No_ligand No_ligand Inactive DFGin 5.3055 12.668 BLAplus -114.06, 158.28 58.5, 36.24 -80.5, -13.9 51.72, 86.53 -109.31, 19.2 in-in in 7.2758 Saltbr-in 2.7316 HRD-in -70.87, -53.69 82.76, -12.35 in-out-out SNCioo out-out ActLoopNT-out 8.1549 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.24, 139.82 APE9-dihe-in -109.2, 91.15 APE8-dihe-out -56.36, -21.76 APE8-rot-na 332.77 APE67-dihe-in -69.44, -8.72 -57.84, -25.29 APE12-dist-na 19.3716 APE11-dist-na 21.0921 APE10-dist-na 17.0986 APE9-dist-out 11.8664 C477A,R664E None None XRAY 1.501 0.223 0.248 A 323.0 283.0 14 30 30 0 [[467, 745]] 1.0 4qqt Homo sapiens TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4TYGA P22455 447 751 802.0 No_ligand No_ligand Inactive DFGin 5.0364 13.2643 BLAplus -113.04, 168.56 59.21, 26.28 -74.51, -27.59 55.83, 78.88 -116.06, 38.07 in-in in 8.3604 Saltbr-in 2.9431 HRD-in -76.3, -50.92 72.53, 0.99 in-out-out SNCioo out-out ActLoopNT-out 9.5886 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -69.06, 164.09 APE9-dihe-in -68.59, 127.31 APE8-dihe-in -75.26, 70.92 APE8-rot-na 33.17 APE67-dihe-in -73.51, -8.42 -61.75, -39.15 APE12-dist-na 16.4144 APE11-dist-na 14.362 APE10-dist-na 17.0158 APE9-dist-out 8.5826 None None None XRAY 2.4 0.204 0.238 A 311.0 290.0 15 30 30 0 [[467, 745]] 1.0 4tyg Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7WCXA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.2632 13.1414 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.7923 Saltbr-in 2.5114 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.6444 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.0736 APE11-dist-na 20.85 APE10-dist-na 16.8219 APE9-dist-out 11.9043 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcx Homo sapiens TYR_FGFR4_HUMAN TYR 7e-101 342.8 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7YBXA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.4873 13.1535 BLAplus -117.55, 160.19 54.53, 49.02 -91.8, -26.59 44.5, 84.85 -106.57, 50.06 in-in in 7.5589 Saltbr-in 2.5688 HRD-in -80.18, -45.42 74.32, -9.85 in-out-out SNCioo out-out ActLoopNT-out 8.6851 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.48, 136.62 APE9-dihe-in -109.39, 93.32 APE8-dihe-out -58.06, -17.41 APE8-rot-na 334.8 APE67-dihe-in -75.5, -1.38 -66.17, -23.12 APE12-dist-na 19.6829 APE11-dist-na 21.3888 APE10-dist-na 17.2899 APE9-dist-out 11.925 V550M,R664E None None XRAY 2.233 0.182 0.22 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7ybx Homo sapiens TYR_FGFR4_HUMAN TYR 7e-101 342.8 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7WCWA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.8394 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.5817 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.6329 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.4349 APE11-dist-na 20.9958 APE10-dist-na 16.9286 APE9-dist-out 11.8399 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcw Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7YBPA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.6943 13.112 BLAplus -118.3, 157.64 52.77, 54.66 -79.94, -64.81 29.11, 91.47 -101.86, 63.71 in-in in 7.5294 Saltbr-in 2.4249 HRD-in -81.24, -48.67 73.48, -6.26 in-out-out SNCioo out-out ActLoopNT-out 8.8248 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.22, 136.85 APE9-dihe-in -109.57, 90.67 APE8-dihe-out -55.15, -19.67 APE8-rot-na 333.84 APE67-dihe-in -75.88, -4.09 -65.13, -21.92 APE12-dist-na 20.005 APE11-dist-na 21.5264 APE10-dist-na 17.3869 APE9-dist-out 11.8922 V550L,R664E None None XRAY 2.243 0.178 0.214 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7ybp Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 8KH8A P22455 453 751 802.0 VVW:802 Type1 Inactive DFGin 5.4727 13.1344 BLAplus -118.53, 158.78 61.66, 36.82 -83.32, -20.9 47.14, 88.2 -101.16, 42.7 in-in in 7.5141 Saltbr-in 2.6689 HRD-in -75.42, -56.09 83.49, -11.36 in-out-out SNCioo out-out ActLoopNT-out 8.7477 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.21, 138.97 APE9-dihe-in -107.92, 92.76 APE8-dihe-out -57.64, -22.35 APE8-rot-na 332.41 APE67-dihe-in -70.15, -6.75 -57.07, -25.4 APE12-dist-na 19.9437 APE11-dist-na 21.4858 APE10-dist-na 17.3401 APE9-dist-out 11.9102 C477A,V550L,R664E None None XRAY 1.49 0.169 0.197 A 309.0 299.0 0 30 30 0 [[467, 745]] 1.0 8kh8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6JPJA P22455 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.6584 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.2473 Saltbr-in 2.3178 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.0019 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.2943 APE11-dist-na 21.0682 APE10-dist-na 17.1289 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311.0 299.0 0 30 30 0 [[467, 745]] 1.0 6jpj Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 9K0IA P22455 453 752 802.0 A1EEW:801 Type1 Inactive DFGin 5.309 12.7633 BLAplus -115.86, 158.69 55.98, 44.95 -85.41, -17.3 44.0, 85.95 -114.13, 46.58 in-out in 7.3477 Saltbr-out 4.8758 HRD-in -75.84, -47.79 74.65, -0.7 out-out-out SNCooo out-out ActLoopNT-out 8.5564 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.32, 134.99 APE9-dihe-in -108.67, 92.7 APE8-dihe-out -58.49, -17.91 APE8-rot-na 335.2 APE67-dihe-in -74.49, -4.34 -64.54, -23.8 APE12-dist-na 19.4446 APE11-dist-na 21.0366 APE10-dist-na 16.9379 APE9-dist-out 11.8701 None None None XRAY 2.236 0.178 0.217 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 9k0i Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 9K0JA P22455 453 752 802.0 A1EEX:801 Type1 Inactive DFGin 5.3142 12.9705 BLAplus -112.37, 155.75 53.23, 48.1 -84.71, -20.48 44.35, 88.64 -103.37, 33.18 in-in in 7.3016 Saltbr-in 2.3518 HRD-in -79.51, -52.63 79.39, -8.08 in-out-out SNCioo out-out ActLoopNT-out 8.6182 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.26, 135.8 APE9-dihe-in -108.17, 93.1 APE8-dihe-out -57.75, -21.67 APE8-rot-na 334.34 APE67-dihe-in -72.28, -6.39 -60.48, -25.43 APE12-dist-na 19.6566 APE11-dist-na 21.2296 APE10-dist-na 17.1123 APE9-dist-out 11.8497 None None None XRAY 2.068 0.168 0.205 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 9k0j Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 8W5CA P22455 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.0744 12.6264 BLAplus -113.45, 160.91 56.16, 49.61 -96.83, -7.74 55.25, 86.57 -110.59, 38.95 in-in in 7.4489 Saltbr-in 2.8875 HRD-in -80.69, -46.77 71.02, -3.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -45.86 APE8-dihe-in -77.5, 69.04 APE8-rot-na 31.31 APE67-dihe-in -69.88, -10.46 -68.35, -23.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0166 None None None XRAY 2.3 0.231 0.264 A 300.0 267.0 33 30 13 17 [[467, 745]] 1.0 8w5c Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 8W5CB P22455 453 752 802.0 VZO:801 Type1 Inactive DFGin 5.1188 12.6869 BLAplus -112.49, 158.46 58.84, 48.55 -96.24, -11.93 55.51, 85.76 -106.62, 34.09 in-in in 7.5153 Saltbr-in 2.7151 HRD-in -78.98, -47.31 70.01, -1.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.73 APE8-dihe-in -76.63, 74.51 APE8-rot-na 30.6 APE67-dihe-in -68.94, -14.77 -70.82, -21.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.9867 None None None XRAY 2.3 0.231 0.264 B 300.0 263.0 37 30 13 17 [[467, 745]] 1.0 8w5c Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7VJLA P22455 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.3011 12.4196 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.4851 Saltbr-in 2.9035 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301.0 263.0 37 30 11 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7VJLB P22455 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.4049 13.2037 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.8757 Saltbr-in 2.6652 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301.0 266.0 35 30 11 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6YI8A P22455 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.0516 12.5848 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.1286 APE9-dist-out 9.5625 None None None XRAY 2.13 0.198 0.231 A 307.0 277.0 24 30 15 15 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6YI8B P22455 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.5513 13.0744 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.3993 Saltbr-in 2.8136 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0812 None None None XRAY 2.13 0.198 0.231 B 307.0 270.0 32 30 12 18 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 5NUDA P22455 453 753 802.0 99K:60801 Type1 Inactive DFGin 5.6006 13.1307 BLAplus -103.97, 165.83 57.11, 38.22 -87.24, -12.04 51.74, 90.01 -124.91, 999.0 in-none in 7.7464 Saltbr-none 999.0 HRD-in -60.07, -52.99 79.18, -24.41 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -112.95 APE9-dihe-in -78.26, 150.38 APE8-dihe-in -83.02, 51.4 APE8-rot-na 27.64 APE67-dihe-in -63.02, -12.3 -43.5, -50.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.744 None None None XRAY 2.5 999.0 999.0 A 307.0 267.0 34 30 13 17 [[467, 745]] 1.0 5nud Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4TYIA P22455 447 750 802.0 38O:60801 Type1 Inactive DFGin 5.0167 12.7565 BLAplus -124.41, 161.93 65.25, 9.26 -54.13, -39.53 65.77, 95.11 -82.78, -10.75 in-out in 7.4415 Saltbr-out 5.5181 HRD-out -72.43, 150.77 -73.64, -70.77 out-out-out SNCooo out-out ActLoopNT-out 8.0317 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.18 APE8-dihe-in -82.6, 72.32 APE8-rot-na 33.83 APE67-dihe-in -58.23, -33.51 -75.34, -45.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2926 None None None XRAY 3.4 0.281 0.34 A 311.0 276.0 28 30 16 14 [[467, 745]] 1.0 4tyi Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7WCTA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.4993 13.0077 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.4757 Saltbr-in 2.8808 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.4968 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.4627 APE11-dist-na 21.0452 APE10-dist-na 17.0744 APE9-dist-out 11.7717 R664E None None XRAY 2.106 0.184 0.217 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wct Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7YBOA P22455 453 752 802.0 IH7:801 Type1 Inactive DFGin 5.4241 13.0038 BLAplus -109.16, 160.64 54.99, 45.18 -87.51, -29.93 42.89, 87.09 -102.4, 91.8 in-in in 7.6378 Saltbr-in 3.5242 HRD-in -80.44, -50.18 72.25, -3.15 in-out-out SNCioo out-out ActLoopNT-out 8.547 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -92.41, 138.05 APE9-dihe-in -107.71, 88.36 APE8-dihe-out -54.72, -19.34 APE8-rot-na 336.83 APE67-dihe-in -77.24, 0.55 -64.65, -24.27 APE12-dist-na 18.6819 APE11-dist-na 20.4659 APE10-dist-na 16.682 APE9-dist-out 11.5458 R664E None None XRAY 2.307 0.209 0.254 A 311.0 294.0 6 30 30 0 [[467, 745]] 1.0 7ybo Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7YC1A P22455 453 752 802.0 IIQ:801 Type1 Inactive DFGin 5.7966 12.7769 BLAplus -117.27, 155.16 56.14, 51.47 -92.56, -26.45 40.46, 83.33 -101.9, 30.14 in-in in 7.3679 Saltbr-in 2.3606 HRD-in -69.13, -51.39 74.34, -2.39 in-out-out SNCioo out-out ActLoopNT-out 8.4343 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.9, 135.56 APE9-dihe-in -107.22, 92.14 APE8-dihe-out -55.34, -21.49 APE8-rot-na 335.34 APE67-dihe-in -73.76, 1.53 -66.5, -22.57 APE12-dist-na 19.9838 APE11-dist-na 21.5683 APE10-dist-na 17.4629 APE9-dist-out 11.9241 R664E None None XRAY 2.535 0.185 0.226 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7yc1 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7YC3A P22455 453 752 802.0 IIW:801 Type1 Inactive DFGin 5.3266 12.5268 BLAplus -110.77, 158.7 57.83, 39.6 -81.75, -23.54 48.21, 88.5 -97.33, 32.48 in-in in 7.2262 Saltbr-in 2.6224 HRD-in -77.12, -53.67 78.69, -9.75 in-out-out SNCioo out-out ActLoopNT-out 8.4275 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.63, 139.81 APE9-dihe-in -109.42, 92.27 APE8-dihe-out -57.58, -22.6 APE8-rot-na 330.14 APE67-dihe-in -71.59, -6.73 -57.28, -26.46 APE12-dist-na 19.8981 APE11-dist-na 21.5073 APE10-dist-na 17.3261 APE9-dist-out 11.9005 R664E None None XRAY 1.987 0.163 0.196 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7yc3 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 8KH6A P22455 454 750 802.0 VVI:802 Type1 Inactive DFGin 5.8146 12.9125 BLAplus -119.68, 156.05 60.85, 41.93 -89.33, -24.21 45.12, 83.84 -107.44, 54.7 in-in in 7.3491 Saltbr-in 2.2082 HRD-in -74.63, -55.79 82.32, -9.59 in-out-out SNCioo out-out ActLoopNT-out 8.7001 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.33, 136.78 APE9-dihe-in -108.3, 90.73 APE8-dihe-out -60.36, -21.53 APE8-rot-na 335.21 APE67-dihe-in -71.62, -5.23 -55.35, -27.56 APE12-dist-na 19.541 APE11-dist-na 21.2767 APE10-dist-na 17.1367 APE9-dist-out 11.9198 R664E None None XRAY 1.62 0.205 0.228 A 311.0 289.0 8 30 30 0 [[467, 745]] 1.0 8kh6 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 8KH7A P22455 454 751 802.0 VVW:802 Type1 Inactive DFGin 5.2756 12.7215 BLAplus -115.76, 162.05 57.7, 35.04 -83.79, -12.86 51.09, 87.09 -105.89, 24.32 in-in in 7.4168 Saltbr-in 2.7818 HRD-in -69.92, -54.01 83.03, -10.74 in-out-out SNCioo out-out ActLoopNT-out 8.5138 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -75.04, 139.88 APE9-dihe-in -109.97, 90.79 APE8-dihe-out -58.47, -20.09 APE8-rot-na 333.49 APE67-dihe-in -69.7, -7.45 -60.7, -23.51 APE12-dist-na 19.7984 APE11-dist-na 21.4206 APE10-dist-na 17.2658 APE9-dist-out 11.9913 R664E None None XRAY 1.52 0.166 0.195 A 311.0 290.0 8 30 30 0 [[467, 745]] 1.0 8kh7 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6IUOA P22455 445 750 802.0 AWX:60801 Type1 Inactive DFGin 5.1536 13.8985 BLAplus -116.17, 174.07 60.09, 13.1 -64.05, -29.8 62.3, 87.1 -83.94, 18.54 in-in in 8.0277 Saltbr-in 2.9987 HRD-in -65.57, -53.25 79.62, -17.82 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.56 APE8-dihe-out -49.41, -24.26 APE8-rot-na 19.79 APE67-dihe-in -70.32, -14.96 -48.88, -39.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.6282 R664E None None XRAY 2.3 0.188 0.232 A 322.0 274.0 32 30 13 17 [[467, 745]] 1.0 6iuo Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6IUPA P22455 452 750 802.0 AX0:801 Type1 Inactive DFGin 5.074 13.5259 BLAplus -116.15, 153.2 62.1, 31.67 -67.34, -18.6 49.7, 87.36 -110.99, 17.09 in-in in 8.1239 Saltbr-in 2.7702 HRD-in -75.32, -53.06 85.17, -10.28 in-out-out SNCioo out-out ActLoopNT-out 8.4425 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.61, 140.51 APE9-dihe-in -109.08, 92.15 APE8-dihe-out -61.13, -19.99 APE8-rot-na 336.97 APE67-dihe-in -72.51, -7.5 -57.22, -22.29 APE12-dist-na 18.5305 APE11-dist-na 20.7096 APE10-dist-na 16.798 APE9-dist-out 11.9489 R664E None None XRAY 2.0 0.172 0.228 A 322.0 288.0 11 30 30 0 [[467, 745]] 1.0 6iup Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4XCUA P22455 453 751 802.0 40M:61002 Type1.5_Back Inactive DFGin 5.265 13.6418 BLAplus -110.08, 165.26 52.58, 39.15 -92.79, -5.77 54.37, 86.93 -89.94, -0.54 in-in in 8.2197 Saltbr-in 3.4401 HRD-in -58.72, -59.42 79.42, -2.24 in-out-out SNCioo out-out ActLoopNT-out 5.239 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.17, 166.24 APE9-dihe-in -114.18, 125.28 APE8-dihe-out -51.43, -25.8 APE8-rot-na 334.81 APE67-dihe-in -65.82, -4.36 -63.03, -21.58 APE12-dist-na 20.3582 APE11-dist-na 20.9011 APE10-dist-na 19.2643 APE9-dist-out 11.1555 L449M None None XRAY 1.71 0.196 0.243 A 300.0 287.0 3 30 30 0 [[467, 745]] 1.0 4xcu Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6NVGA P22455 453 751 802.0 XL8:60804 Type1.5_Back Inactive DFGin 5.2263 13.3448 BLAplus -104.78, 161.09 56.06, 37.4 -85.63, -9.18 54.54, 85.27 -109.59, 3.52 in-in in 7.6492 Saltbr-in 2.7916 HRD-in -75.55, -55.06 84.65, -16.54 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.34 APE8-rot-na 33.55 APE67-dihe-in -70.37, -12.25 -60.57, -30.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.99 0.206 0.233 A 300.0 272.0 18 30 12 18 [[467, 745]] 1.0 6nvg Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6NVHA P22455 453 750 802.0 XL6:60803 Type1.5_Back Inactive DFGin 5.2448 13.4006 BLAplus -105.65, 156.33 59.41, 40.23 -87.91, -7.9 56.0, 80.86 -110.13, 11.2 in-in in 7.6449 Saltbr-in 2.9087 HRD-in -72.21, -55.48 85.67, -17.85 in-out-out SNCioo out-out ActLoopNT-out 8.8817 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.32 APE8-dihe-in -79.08, 68.56 APE8-rot-na 34.44 APE67-dihe-in -72.6, -11.42 -66.3, -25.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0923 None None None XRAY 1.9 0.213 0.234 A 300.0 271.0 18 30 15 15 [[467, 745]] 1.0 6nvh Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6NVIA P22455 453 750 802.0 XL7:60801 Type1.5_Back Inactive DFGin 5.2279 13.424 BLAplus -98.74, 158.44 61.07, 34.7 -84.24, 4.13 54.35, 83.32 -125.28, 10.73 in-in in 7.5195 Saltbr-in 2.7875 HRD-in -67.86, -63.14 93.89, -12.35 in-out-out SNCioo out-out ActLoopNT-out 10.8082 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.76 APE8-dihe-in -79.66, 67.36 APE8-rot-na 35.8 APE67-dihe-in -54.63, -21.11 -49.95, -49.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0138 None None None XRAY 2.117 0.244 0.281 A 300.0 270.0 19 30 17 13 [[467, 745]] 1.0 6nvi Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6NVJA P22455 453 751 802.0 XL5:60805 Type1.5_Back Inactive DFGin 5.1556 13.4282 BLAplus -115.45, 166.84 46.39, 45.37 -92.54, -5.84 62.78, 75.02 -111.78, 12.99 in-in in 7.7389 Saltbr-in 3.0352 HRD-in -74.22, -50.72 84.72, -17.15 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 41.29 APE8-rot-na 32.25 APE67-dihe-in -71.97, -10.77 -70.51, -33.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.225 0.271 A 300.0 270.0 20 30 12 18 [[467, 745]] 1.0 6nvj Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6NVKA P22455 453 750 802.0 XL9:60804 Type1.5_Back Inactive DFGin 5.4097 13.4021 BLAplus -111.15, 166.43 49.96, 40.14 -90.15, -10.4 62.08, 83.95 -67.49, -62.92 in-in in 7.8908 Saltbr-in 3.324 HRD-in -72.5, -53.93 83.1, -15.01 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.17 APE8-rot-na 32.94 APE67-dihe-in -75.58, -9.12 -59.15, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.216 0.266 A 300.0 268.0 21 30 12 18 [[467, 745]] 1.0 6nvk Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6V9CA P22455 453 751 802.0 QS7:801 Type1.5_Back Inactive DFGin 5.7038 13.2065 BLAplus -115.43, 161.07 52.83, 42.01 -94.99, -8.85 55.26, 83.8 -80.51, -1.36 in-in in 7.3577 Saltbr-in 2.8459 HRD-in -65.42, -53.69 80.61, -8.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.47, 131.07 APE9-dihe-in -110.88, 96.52 APE8-dihe-out -54.06, -26.94 APE8-rot-na 330.97 APE67-dihe-in -67.11, -10.72 -50.75, -30.29 APE12-dist-na 20.6793 APE11-dist-na 22.1231 APE10-dist-na 18.0039 APE9-dist-out 11.5642 None None None XRAY 1.9 0.201 0.227 A 300.0 279.0 11 30 24 6 [[467, 745]] 1.0 6v9c Homo sapiens TYR_FGFR4_HUMAN TYR 8e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7DTZA P22455 453 751 802.0 HHL:801 Type1.5_Back Inactive DFGin 5.0405 13.2312 BLAplus -106.32, 155.01 52.81, 43.27 -81.9, -13.46 51.78, 85.83 -110.23, 20.15 in-in in 7.7767 Saltbr-in 2.9612 HRD-in -70.3, -51.75 81.02, -9.17 in-out-out SNCioo out-out ActLoopNT-out 8.4301 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -76.5, 137.82 APE9-dihe-in -110.53, 91.62 APE8-dihe-out -56.53, -20.36 APE8-rot-na 332.34 APE67-dihe-in -73.0, -6.55 -63.9, -22.13 APE12-dist-na 19.3461 APE11-dist-na 21.0511 APE10-dist-na 16.9904 APE9-dist-out 11.8846 C477A,R664E None None XRAY 2.01 0.167 0.198 A 309.0 299.0 0 30 30 0 [[467, 745]] 1.0 7dtz Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 6JPEA P22455 452 751 802.0 BYU:801 Type1.5_Back Inactive DFGin 5.2472 13.463 BLAplus -103.06, 149.11 61.81, 37.94 -77.24, -14.19 46.99, 86.6 -117.47, 17.69 in-in in 7.709 Saltbr-in 2.7112 HRD-in -73.19, -51.91 79.91, -9.36 in-out-out SNCioo out-out ActLoopNT-out 8.5997 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.69, 142.25 APE9-dihe-in -110.48, 89.58 APE8-dihe-out -59.73, -20.88 APE8-rot-na 330.5 APE67-dihe-in -72.7, -3.42 -57.67, -24.83 APE12-dist-na 18.7859 APE11-dist-na 20.7845 APE10-dist-na 16.8151 APE9-dist-out 12.016 C477A,R664E None None XRAY 1.601 0.153 0.183 A 311.0 298.0 2 30 30 0 [[467, 745]] 1.0 6jpe Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 5NWZB P22455 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.4857 13.4174 BLAplus -113.86, 158.8 59.13, 38.36 -84.32, -23.92 49.52, 81.33 -128.83, 999.0 in-in in 8.1221 Saltbr-in 3.3914 HRD-in -56.44, -67.62 94.06, -17.19 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 141.23 APE9-dihe-in -80.83, 151.57 APE8-dihe-in -83.52, 61.94 APE8-rot-na 31.92 APE67-dihe-in -70.65, -15.95 -46.83, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3756 None None None XRAY 2.37 999.0 999.0 B 307.0 268.0 31 30 13 17 [[467, 745]] 1.0 5nwz Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7F3MA P22455 453 753 802.0 GX3:801 Type1.5_Back Inactive DFGin 5.5524 13.1922 BLAplus -107.13, 152.62 56.03, 47.93 -89.2, -14.08 45.11, 81.2 -107.31, 16.55 in-in in 7.847 Saltbr-in 3.3992 HRD-in -72.1, -48.45 71.34, -0.81 in-out-out SNCioo out-out ActLoopNT-out 8.396 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -87.64, 146.43 APE9-dihe-in -113.34, 91.66 APE8-dihe-out -53.3, -18.71 APE8-rot-na 332.63 APE67-dihe-in -75.11, -5.8 -67.3, -21.18 APE12-dist-na 18.0889 APE11-dist-na 20.7152 APE10-dist-na 17.0429 APE9-dist-out 11.763 R664E None None XRAY 2.289 0.19 0.237 A 311.0 298.0 3 30 30 0 [[467, 745]] 1.0 7f3m Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7V29A P22455 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.457 13.1251 BLAplus -121.31, 170.65 56.14, 38.3 -89.91, -13.64 53.46, 82.04 -105.81, 18.85 in-in in 7.6976 Saltbr-in 2.8139 HRD-in -73.56, -51.53 78.84, -9.11 in-out-out SNCioo out-out ActLoopNT-out 8.5074 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -95.33, 150.7 APE9-dihe-in -110.55, 91.7 APE8-dihe-out -59.49, -19.26 APE8-rot-na 334.55 APE67-dihe-in -66.16, -14.6 -59.54, -27.23 APE12-dist-na 16.2016 APE11-dist-na 19.0391 APE10-dist-na 15.9727 APE9-dist-out 11.4004 R664E None None XRAY 1.983 0.194 0.241 A 311.0 293.0 4 30 30 0 [[467, 745]] 1.0 7v29 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 7V29B P22455 454 750 802.0 5JR:801 Type1.5_Back Inactive DFGin 5.303 13.2578 BLAplus -114.54, 165.88 57.72, 42.48 -96.03, -8.41 54.15, 80.06 -108.88, 26.62 in-in in 7.7796 Saltbr-in 2.5444 HRD-in -71.41, -53.8 82.9, -10.79 in-out-out SNCioo out-out ActLoopNT-out 8.4868 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -86.98, 141.4 APE9-dihe-in -110.54, 96.59 APE8-dihe-out -61.83, -15.99 APE8-rot-na 335.67 APE67-dihe-in -71.36, -5.88 -59.93, -27.74 APE12-dist-na 17.3778 APE11-dist-na 19.7882 APE10-dist-na 16.4005 APE9-dist-out 11.3985 R664E None None XRAY 1.983 0.194 0.241 B 311.0 290.0 7 30 30 0 [[467, 745]] 1.0 7v29 Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 8XLQA P22455 453 751 802.0 A1LVQ:801 Type1.5_Back Inactive DFGin 5.4641 13.0254 BLAplus -110.49, 154.34 56.41, 53.19 -87.86, -15.94 35.15, 87.75 -151.42, 999.0 in-in in 7.6576 Saltbr-in 3.2542 HRD-in -77.24, -55.4 78.04, -11.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.75, 139.57 APE9-dihe-in -110.17, 94.87 APE8-dihe-out -60.19, -19.05 APE8-rot-na 334.14 APE67-dihe-in -73.66, -3.29 -59.9, -24.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8209 R664E None None XRAY 1.95 0.171 0.211 A 311.0 296.0 3 30 27 3 [[467, 745]] 1.0 8xlq Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4QQCA P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGin 5.3786 13.2944 BLAplus -105.5, 167.64 62.41, 26.27 -78.09, -25.76 56.21, 83.69 -101.85, 145.28 in-in in 8.0664 Saltbr-in 3.2123 HRD-in -73.92, -52.23 79.6, -15.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.52 APE8-dihe-out -46.45, -18.28 APE8-rot-na 329.31 APE67-dihe-in -73.13, -9.32 -59.41, -33.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.649 R664E None None XRAY 2.4 0.163 0.214 A 323.0 271.0 35 30 13 17 [[467, 745]] 1.0 4qqc Homo sapiens TYR_FGFR4_HUMAN TYR 2.2e-100 341.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 8KH9A P22455 454 752 802.0 VVW:903 Type1 Inactive DFGin 5.6284 13.2287 BLBplus -116.73, 162.01 54.49, 42.82 -90.48, 158.22 47.04, 88.15 53.89, 22.89 in-in in 7.5394 Saltbr-in 2.6915 HRD-in -76.16, -55.94 82.55, -10.33 in-out-out SNCioo out-out ActLoopNT-out 8.7222 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.55, 140.78 APE9-dihe-in -111.22, 92.1 APE8-dihe-out -57.69, -22.37 APE8-rot-na 333.28 APE67-dihe-in -71.01, -5.51 -56.46, -26.43 APE12-dist-na 20.3132 APE11-dist-na 21.8343 APE10-dist-na 17.5883 APE9-dist-out 11.963 C477A,V550M,R664E None None XRAY 1.42 0.171 0.193 A 300.0 299.0 0 30 30 0 [[467, 745]] 1.0 8kh9 Homo sapiens TYR_FGFR4_HUMAN TYR 6.3e-101 343.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 5NWZA P22455 454 752 802.0 9CT:801 Type1.5_Back Inactive DFGin 5.8412 13.0386 BLBplus -113.97, 156.19 61.74, 48.41 -92.8, 152.39 41.89, 84.86 -162.16, 999.0 in-out in 8.0285 Saltbr-out 4.725 HRD-in -59.82, -67.76 95.11, -14.9 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.43 APE8-dihe-in -81.01, 64.72 APE8-rot-na 32.13 APE67-dihe-in -74.52, -12.37 -52.63, -35.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9747 None None None XRAY 2.37 999.0 999.0 A 307.0 271.0 28 30 12 18 [[467, 745]] 1.0 5nwz Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4TYEA P22455 451 753 802.0 No_ligand No_ligand Inactive DFGin 5.829 12.5802 None -91.65, -29.21 -103.02, 104.95 -71.18, -26.95 65.53, 79.96 94.73, -139.66 in-in in 8.2669 Saltbr-in 2.6135 HRD-out -120.78, 153.56 -67.42, -42.5 in-out-out SNCioo out-out ActLoopNT-out 8.3844 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.01 APE8-dihe-in -80.96, 75.64 APE8-rot-na 33.57 APE67-dihe-in -64.71, -19.07 -60.12, -38.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.1877 None None None XRAY 2.8 0.227 0.278 A 311.0 292.0 11 30 23 7 [[467, 745]] 1.0 4tye Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.0214 13.2508 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.3097 Saltbr-out 4.2744 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5xfj Homo sapiens TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.2509 13.8003 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.9065 Saltbr-in 3.5618 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.5407 V550L None None XRAY 2.7 0.27 0.32 A 311.0 269.0 29 30 13 17 [[467, 745]] 1.0 5xff Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.4149 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.7877 Saltbr-in 2.7483 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4055 None None None XRAY 2.352 0.237 0.277 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5jkg Homo sapiens TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4QQ5A P22455 445 750 802.0 37O:60801 Type1.5_Back Inactive DFGout 13.8248 11.1354 BBAminus -99.0, 166.33 -153.32, 109.28 -96.97, 16.74 304.57, 104.6 -130.76, 29.26 in-in in 7.8461 Saltbr-in 2.9055 HRD-in -72.86, -56.2 82.96, -11.73 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.0 APE8-dihe-out -47.81, -19.48 APE8-rot-na 326.35 APE67-dihe-in -66.59, -10.5 -64.2, -38.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2578 V550L,R664E None None XRAY 2.203 0.197 0.234 A 323.0 272.0 34 30 14 16 [[467, 745]] 1.0 4qq5 Homo sapiens TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4R6VA P22455 445 750 802.0 FI3:60801 Type1.5_Back Inactive DFGout 13.7251 11.5939 BBAminus -104.3, 160.0 -151.01, 100.96 -90.12, 14.65 307.32, 109.77 -121.7, 20.63 in-in in 7.9792 Saltbr-in 2.8524 HRD-in -75.49, -50.13 79.72, -18.12 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -44.34 APE8-rot-na 330.88 APE67-dihe-in -70.56, -4.7 -57.71, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V550L,R664E None None XRAY 2.353 0.179 0.227 A 323.0 271.0 35 30 13 17 [[467, 745]] 1.0 4r6v Homo sapiens TYR_FGFR4_HUMAN TYR 3.3e-100 340.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4UXQA P22455 452 750 802.0 0LI:1752 Type2 Inactive DFGout 13.2886 9.6881 BBAminus -132.52, -175.6 -154.98, 108.32 -101.68, -37.05 301.67, 99.59 -82.32, -172.58 in-in in 7.8131 Saltbr-in 2.7274 HRD-in -74.83, -56.93 88.13, -22.48 in-out-out SNCioo out-out ActLoopNT-out 15.96 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -78.09, 139.64 APE9-dihe-in -109.24, 95.28 APE8-dihe-out -52.11, -28.25 APE8-rot-na 327.58 APE67-dihe-in -73.35, -9.88 -60.02, -19.19 APE12-dist-na 12.2275 APE11-dist-na 12.9237 APE10-dist-na 10.1127 APE9-dist-out 11.6116 C477A None None XRAY 1.85 0.205 0.268 A 309.0 286.0 13 30 30 0 [[467, 745]] 1.0 4uxq Homo sapiens TYR_FGFR4_HUMAN TYR 8.2e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4TYJA P22455 447 753 802.0 0LI:60801 Type2 Inactive DFGout 13.629 9.6017 BBAminus -136.8, -177.28 -149.4, 114.79 -98.18, 9.17 298.44, 103.78 79.91, -171.4 in-in in 7.8197 Saltbr-in 2.7569 HRD-in -71.95, -55.51 84.74, -19.01 in-out-out SNCioo out-out ActLoopNT-out 19.1078 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.68 APE8-dihe-in -83.91, 64.17 APE8-rot-na 36.55 APE67-dihe-in -73.09, -8.81 -53.35, -41.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.8188 None None None XRAY 2.45 0.217 0.247 A 311.0 275.0 32 30 15 15 [[467, 745]] 1.0 4tyj Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 4QRCA P22455 454 750 802.0 0LI:802 Type2 Inactive DFGout 13.8479 9.4478 None -128.93, 176.89 -168.87, 140.49 58.84, 41.6 314.29, 151.03 128.95, 161.76 in-in in 7.2685 Saltbr-in 2.5447 HRD-in -73.23, -52.1 79.8, -10.52 in-out-out SNCioo out-out ActLoopNT-out 8.6625 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -79.02, 138.09 APE9-dihe-in -108.95, 92.74 APE8-dihe-out -61.85, -18.49 APE8-rot-na 333.49 APE67-dihe-in -72.31, -7.32 -59.05, -24.57 APE12-dist-na 19.5374 APE11-dist-na 21.0468 APE10-dist-na 16.8729 APE9-dist-out 12.0169 C477A,R664E None None XRAY 1.901 0.173 0.207 A 323.0 297.0 0 30 30 0 [[467, 745]] 1.0 4qrc Homo sapiens TYR_FGFR4_HUMAN TYR 1.5e-100 341.7 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
FGFR4 FGFR4_HUMAN 5NUDB P22455 449 750 802.0 99K:60801 Type1 Inactive None 999.0 999.0 None -104.81, 161.89 46.27, 64.92 -114.7, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.3398 Saltbr-in 2.8094 HRD-in -51.67, -45.87 64.18, -17.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 126.54 APE9-dihe-in -104.07, 151.6 APE8-dihe-in -76.04, 73.43 APE8-rot-na 28.96 APE67-dihe-in -64.78, -21.38 -59.9, -33.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.4064 None None None XRAY 2.5 999.0 999.0 B 307.0 270.0 32 30 12 18 [[467, 745]] 1.0 5nud Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4

TYR_FGFR4 (Fibroblast growth factor receptor 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name