TYR_FGFR1 (Fibroblast growth factor receptor 1)

Total number of chains: 145
Active chains: 3
Uniprot: FGFR1_HUMAN
Kinase Domain Residues: 478 - 756
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 114 78.6% 9UHIA
DFGin BLBplus 11 7.6% 8JQIB
DFGin BLAminus 10 6.9% AF-P11362-K1A
DFGin None 5 3.4% 4NKAB
DFGout None 3 2.1% 4V04A
DFGin BLBminus 1 0.7% 3KXXA
DFGout BBAminus 1 0.7% 4V04B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR1 3GQIA P11362 464 770 822.0 ACP:775 ATPlike Active DFGin 6.4659 13.9462 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.7514 Saltbr-in 2.6904 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.9611 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.0832 APE11-dist-na 11.2584 APE10-dist-na 10.1277 APE9-dist-in 7.1373 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326.0 307.0 0 30 30 0 [[478, 756]] 1.0 3gqi TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 AF-P11362-K1A P11362 470 764 822.0 No_ligand No_ligand Active DFGin 6.5854 13.7448 BLAminus -135.24, -172.55 53.83, 70.53 -87.91, 10.86 290.57, 95.64 -59.32, -30.75 in-in in 7.4533 Saltbr-in 2.6485 HRD-in -70.89, -43.2 66.63, -19.06 in-in-in SNCiii in-in ActLoopNT-in 2.9002 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.78, 130.17 APE9-dihe-in -137.78, 151.11 APE8-dihe-in -79.35, 77.49 APE8-rot-na 37.15 APE67-dihe-in -67.5, -12.86 -47.07, -41.3 APE12-dist-na 14.3936 APE11-dist-na 9.9311 APE10-dist-na 9.9898 APE9-dist-in 6.5057 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[478, 756]] 1.0 AF-P11362-K1 TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 AF-P11362-K3A P11362 470 764 822.0 No_ligand No_ligand Active DFGin 6.1465 13.5208 BLAminus -139.78, -177.08 59.37, 66.68 -79.98, 12.43 289.81, 96.12 -59.82, -28.59 in-in in 7.9064 Saltbr-in 2.6591 HRD-in -80.49, -43.82 61.4, -3.43 in-in-in SNCiii in-in ActLoopNT-in 2.9224 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.53, 136.75 APE9-dihe-in -134.21, 129.98 APE8-dihe-in -82.7, 64.06 APE8-rot-na 35.6 APE67-dihe-in -69.03, -12.46 -46.62, -44.88 APE12-dist-na 13.4611 APE11-dist-na 9.7937 APE10-dist-na 8.1551 APE9-dist-in 6.648 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[478, 756]] 1.0 AF-P11362-K3 TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3KXXB P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 7.0608 14.5067 BLAminus -138.91, 177.11 64.42, 63.57 -90.83, 31.94 294.07, 81.15 -71.04, -30.05 in-in in 7.2339 Saltbr-in 3.199 HRD-out -89.94, 81.9 -57.82, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.9083 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.01, 74.51 APE9-dihe-in -144.18, 139.02 APE8-dihe-in -51.42, 121.01 APE8-rot-na 327.88 APE67-dihe-in -76.85, -17.4 -68.16, -22.5 APE12-dist-na 14.8931 APE11-dist-na 10.3604 APE10-dist-na 9.1325 APE9-dist-in 5.752 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 B 317.0 305.0 0 30 30 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3KXXC P11362 458 762 822.0 No_ligand No_ligand Inactive DFGin 7.139 13.9922 BLAminus -138.07, -172.42 62.91, 62.15 -92.81, 13.58 296.2, 98.02 -70.01, -16.73 in-in in 7.2426 Saltbr-in 2.6366 HRD-out -88.37, 88.38 -55.25, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.9676 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.88, 68.46 APE9-dihe-in -154.11, 147.86 APE8-dihe-in -47.33, 131.68 APE8-rot-na 28.97 APE67-dihe-in -56.58, -13.9 -82.3, -38.63 APE12-dist-na 15.0864 APE11-dist-na 10.3326 APE10-dist-na 8.9475 APE9-dist-in 6.2614 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 C 317.0 286.0 19 30 30 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3KXXD P11362 458 762 822.0 No_ligand No_ligand Inactive DFGin 6.502 13.6714 BLAminus -133.51, -161.48 51.6, 74.09 -99.67, 22.58 293.84, 93.72 -66.62, -32.71 in-in in 7.5288 Saltbr-in 3.4577 HRD-out -84.43, 73.53 -41.76, -24.93 in-in-in SNCiii in-in ActLoopNT-in 3.1136 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.31, 77.29 APE9-dihe-in -147.89, 135.68 APE8-dihe-in -51.4, 116.54 APE8-rot-na 326.12 APE67-dihe-in -63.39, 3.02 -61.34, -39.64 APE12-dist-na 15.473 APE11-dist-na 10.5609 APE10-dist-na 8.8353 APE9-dist-in 6.2397 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 D 317.0 286.0 19 30 30 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5FLFA P11362 460 762 822.0 No_ligand No_ligand Inactive DFGin 6.5659 13.9215 BLAminus -130.07, -173.3 57.53, 81.51 -106.56, 20.58 287.47, 88.65 -65.69, -26.36 in-in in 7.0608 Saltbr-in 2.6235 HRD-in -77.09, -44.33 71.36, -17.68 in-in-out SNCiio in-out ActLoopNT-in 2.8743 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -122.27, 31.65 APE9-dihe-in -120.82, 141.16 APE8-dihe-in -55.6, 118.0 APE8-rot-na 17.74 APE67-dihe-in -68.76, -3.74 -51.76, -42.09 APE12-dist-na 14.9694 APE11-dist-na 10.4873 APE10-dist-na 8.0447 APE9-dist-in 5.7595 R675G None None XRAY 2.58 0.197 0.255 A 310.0 296.0 7 30 30 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5FLFB P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 6.597 14.2709 BLAminus -131.38, -174.56 57.69, 69.98 -91.26, 21.65 284.1, 89.91 -69.58, -18.15 in-in in 7.2083 Saltbr-in 2.6613 HRD-in -77.24, -42.46 70.08, -13.13 in-in-out SNCiio in-out ActLoopNT-in 2.9501 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.34, 21.86 APE9-dihe-in -108.05, 143.02 APE8-dihe-in -54.9, 122.45 APE8-rot-na 333.47 APE67-dihe-in -66.56, -8.26 -58.19, -40.45 APE12-dist-na 14.7668 APE11-dist-na 10.3425 APE10-dist-na 7.6761 APE9-dist-in 5.5875 R675G None None XRAY 2.58 0.197 0.255 B 310.0 292.0 13 30 30 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5FLFC P11362 464 763 822.0 No_ligand No_ligand Inactive DFGin 6.8788 14.9038 BLAminus -128.63, -179.22 56.68, 76.02 -97.55, 23.96 288.87, 80.23 -64.42, -24.4 in-in in 7.8673 Saltbr-in 2.5932 HRD-in -77.84, -41.46 68.92, -13.37 in-in-out SNCiio in-out ActLoopNT-in 3.0119 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.74, 13.42 APE9-dihe-in -108.0, 146.11 APE8-dihe-in -55.87, 118.95 APE8-rot-na 334.41 APE67-dihe-in -77.03, -3.15 -66.33, -25.17 APE12-dist-na 14.7227 APE11-dist-na 11.0185 APE10-dist-na 8.0397 APE9-dist-in 5.5345 R675G None None XRAY 2.58 0.197 0.255 C 310.0 283.0 17 30 30 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5FLFD P11362 465 763 822.0 No_ligand No_ligand Inactive DFGin 6.5626 14.0755 BLAminus -137.61, -174.47 56.6, 77.52 -99.56, 24.88 289.94, 80.48 -64.3, -28.41 in-in in 7.2769 Saltbr-in 2.8242 HRD-in -82.09, -46.03 69.99, -9.21 in-in-out SNCiio in-out ActLoopNT-in 2.9337 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.36, 26.56 APE9-dihe-in -112.27, 140.35 APE8-dihe-in -53.21, 117.11 APE8-rot-na 330.63 APE67-dihe-in -75.55, -3.28 -53.96, -35.33 APE12-dist-na 14.9431 APE11-dist-na 10.5064 APE10-dist-na 7.9926 APE9-dist-in 5.5979 R675G None None XRAY 2.58 0.197 0.255 D 310.0 290.0 9 30 30 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWIA P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 5.1902 13.2874 BLAplus -105.16, 163.21 56.87, 28.19 -74.61, -16.94 54.32, 87.9 -104.05, 11.37 in-in in 7.9641 Saltbr-in 2.6905 HRD-in -73.3, -52.29 82.32, -10.23 in-out-out SNCioo out-out ActLoopNT-out 8.0996 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.29, 144.76 APE9-dihe-in -100.4, 99.63 APE8-dihe-out -55.34, -23.98 APE8-rot-na 331.55 APE67-dihe-in -74.41, -9.61 -59.83, -21.73 APE12-dist-na 17.4922 APE11-dist-na 19.0334 APE10-dist-na 16.5776 APE9-dist-out 11.2323 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 A 317.0 305.0 0 30 30 0 [[478, 756]] 1.0 4rwi TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWIB P11362 461 763 822.0 No_ligand No_ligand Inactive DFGin 5.1408 13.1536 BLAplus -106.54, 164.69 57.29, 29.78 -77.53, -18.65 57.49, 89.17 -101.92, 7.65 in-in in 7.8788 Saltbr-in 2.8702 HRD-in -73.64, -53.72 81.97, -10.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.37, 146.39 APE9-dihe-in -96.99, 106.58 APE8-dihe-out -51.08, -23.64 APE8-rot-na 329.78 APE67-dihe-in -74.22, -7.08 -61.58, -21.03 APE12-dist-na 999.0 APE11-dist-na 21.6378 APE10-dist-na 19.3161 APE9-dist-out 11.6321 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 B 317.0 280.0 23 30 25 5 [[478, 756]] 1.0 4rwi TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 1FGKA P11362 464 762 822.0 No_ligand No_ligand Inactive DFGin 5.0399 13.1527 BLAplus -117.08, 161.77 60.28, 24.85 -72.88, -22.06 56.54, 82.81 -106.67, 14.32 in-in in 7.8316 Saltbr-in 3.3783 HRD-in -62.23, -53.96 80.79, -13.7 in-out-out SNCioo out-out ActLoopNT-out 8.9817 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.16, 160.27 APE9-dihe-in -100.02, 107.51 APE8-dihe-out -50.6, -26.19 APE8-rot-na 325.57 APE67-dihe-in -72.28, -4.51 -59.98, -18.19 APE12-dist-na 19.5072 APE11-dist-na 20.6663 APE10-dist-na 19.1079 APE9-dist-out 11.7951 None None None XRAY 2.0 0.213 0.261 A 310.0 278.0 21 30 30 0 [[478, 756]] 1.0 1fgk TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 1FGKB P11362 461 761 822.0 No_ligand No_ligand Inactive DFGin 5.1921 12.9337 BLAplus -119.81, 158.37 63.11, 25.45 -77.92, -15.92 57.79, 81.67 -107.61, 13.08 in-in in 7.691 Saltbr-in 3.0319 HRD-in -69.81, -40.78 70.38, -11.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.56, 167.66 APE9-dihe-in -110.12, 112.64 APE8-dihe-out -55.04, -21.46 APE8-rot-na 323.57 APE67-dihe-in -69.19, -4.96 -60.35, -22.4 APE12-dist-na 999.0 APE11-dist-na 20.9639 APE10-dist-na 19.5628 APE9-dist-out 11.5716 C488A None None XRAY 2.0 0.213 0.261 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 1fgk TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4UWYA P11362 462 762 822.0 No_ligand No_ligand Inactive DFGin 5.2911 12.8627 BLAplus -108.05, 160.93 49.5, 43.38 -87.31, -20.81 54.11, 89.18 -97.03, 5.71 in-in in 7.5085 Saltbr-in 2.443 HRD-in -75.4, -42.68 70.46, -5.54 in-out-out SNCioo out-out ActLoopNT-out 7.6585 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.93, 150.1 APE9-dihe-in -108.91, 96.97 APE8-dihe-out -51.49, -30.02 APE8-rot-na 332.53 APE67-dihe-in -69.11, -13.52 -51.63, -33.68 APE12-dist-na 16.7309 APE11-dist-na 19.1922 APE10-dist-na 16.4743 APE9-dist-out 11.016 None None None XRAY 2.305 0.214 0.267 A 310.0 296.0 5 30 30 0 [[478, 756]] 1.0 4uwy TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4UWYB P11362 459 762 822.0 No_ligand No_ligand Inactive DFGin 5.1132 12.7868 BLAplus -107.94, 162.87 51.01, 42.84 -88.14, -19.95 53.77, 88.06 -94.96, 5.78 in-in in 7.4181 Saltbr-in 2.548 HRD-in -75.22, -44.02 71.63, -5.56 in-out-out SNCioo out-out ActLoopNT-out 7.7221 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.53 APE8-dihe-out -53.14, -29.69 APE8-rot-na 332.32 APE67-dihe-in -67.22, -11.8 -51.66, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.7326 None None None XRAY 2.305 0.214 0.267 B 310.0 273.0 31 30 16 14 [[478, 756]] 1.0 4uwy TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3KY2A P11362 458 764 822.0 No_ligand No_ligand Inactive DFGin 5.1417 13.3026 BLAplus -122.69, 172.32 46.54, 42.6 -95.25, -13.81 55.54, 83.43 -110.08, 21.37 in-in in 7.9833 Saltbr-in 2.7043 HRD-in -54.04, -52.31 78.54, -4.33 in-out-out SNCioo out-out ActLoopNT-out 7.9047 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.74, 144.51 APE9-dihe-in -109.2, 106.89 APE8-dihe-out -56.11, -24.62 APE8-rot-na 329.61 APE67-dihe-in -74.45, -13.88 -60.05, -25.51 APE12-dist-na 17.0264 APE11-dist-na 19.6184 APE10-dist-na 16.6111 APE9-dist-out 11.1393 C488A,C584S None None XRAY 2.7 0.206 0.252 A 317.0 305.0 2 30 30 0 [[478, 756]] 1.0 3ky2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3KY2B P11362 460 763 822.0 No_ligand No_ligand Inactive DFGin 5.3065 13.1313 BLAplus -120.14, 165.15 53.12, 37.21 -90.32, -21.71 57.04, 89.19 -96.69, 4.05 in-in in 7.7505 Saltbr-in 2.873 HRD-in -63.32, -45.74 74.66, -3.4 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.35, 149.7 APE9-dihe-in -86.12, 120.09 APE8-dihe-out -58.71, -15.12 APE8-rot-na 326.3 APE67-dihe-in -64.29, -14.63 -68.37, -29.74 APE12-dist-na 19.9297 APE11-dist-na 21.2795 APE10-dist-na 19.8376 APE9-dist-out 11.7932 C488A,C584S None None XRAY 2.7 0.206 0.252 B 317.0 280.0 24 30 24 6 [[478, 756]] 1.0 3ky2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWLA P11362 465 765 822.0 No_ligand No_ligand Inactive DFGin 5.2596 13.1901 BLAplus -120.07, 160.93 64.42, 29.27 -80.33, -20.1 51.65, 89.33 -96.98, 0.13 in-in in 7.7737 Saltbr-in 2.9039 HRD-in -75.31, -52.96 79.05, -10.93 in-out-out SNCioo out-out ActLoopNT-out 8.242 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.23, 163.46 APE9-dihe-in -103.38, 113.99 APE8-dihe-out -51.08, -26.28 APE8-rot-na 327.94 APE67-dihe-in -75.8, -7.21 -59.7, -19.52 APE12-dist-na 19.715 APE11-dist-na 21.1796 APE10-dist-na 19.602 APE9-dist-out 11.6028 C488A,C584S None None XRAY 2.193 0.209 0.256 A 317.0 282.0 19 30 27 3 [[478, 756]] 1.0 4rwl TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5FLFE P11362 466 761 822.0 No_ligand No_ligand Inactive DFGin 5.8568 13.3331 BLAplus -107.08, 156.12 59.3, 89.04 -145.68, 9.21 46.94, 85.34 -107.07, -8.42 in-out in 7.681 Saltbr-out 4.1216 HRD-in -76.44, -47.72 79.39, -32.07 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -134.53, 84.16 APE9-dihe-out 70.54, 76.98 APE8-dihe-out -73.71, -15.89 APE8-rot-na 29.38 APE67-dihe-in -66.59, -10.19 -60.2, -29.73 APE12-dist-na 999.0 APE11-dist-na 15.329 APE10-dist-na 19.6281 APE9-dist-out 11.396 R675G None None XRAY 2.58 0.197 0.255 E 310.0 258.0 38 30 16 14 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5AM7A P11362 458 764 822.0 38O:1000 Type1 Inactive DFGin 5.3219 13.4036 BLAplus -119.96, 160.03 61.93, 31.32 -78.06, -16.68 51.95, 91.0 -102.88, 8.06 in-in in 7.7843 Saltbr-in 2.8211 HRD-in -72.13, -53.65 81.66, -13.87 in-out-out SNCioo out-out ActLoopNT-out 8.8441 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.07, 161.69 APE9-dihe-in -97.7, 110.93 APE8-dihe-out -50.41, -28.65 APE8-rot-na 335.18 APE67-dihe-in -73.88, -5.16 -55.74, -23.35 APE12-dist-na 19.8904 APE11-dist-na 21.1924 APE10-dist-na 19.9341 APE9-dist-out 11.8873 V561M None None XRAY 1.957 0.201 0.254 A 310.0 294.0 13 30 30 0 [[478, 756]] 1.0 5am7 TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5AM7B P11362 458 762 822.0 38O:1000 Type1 Inactive DFGin 5.351 13.0562 BLAplus -118.51, 161.73 60.87, 31.35 -81.93, -17.68 51.44, 85.63 -98.47, 10.33 in-in in 7.8786 Saltbr-in 3.092 HRD-in -70.81, -53.93 79.14, -12.6 in-out-out SNCioo out-out ActLoopNT-out 8.4934 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.26, 167.43 APE9-dihe-in -92.91, 111.75 APE8-dihe-out -51.15, -27.96 APE8-rot-na 332.74 APE67-dihe-in -72.49, -4.42 -56.51, -22.72 APE12-dist-na 19.2902 APE11-dist-na 21.0595 APE10-dist-na 19.9352 APE9-dist-out 11.7718 V561M None None XRAY 1.957 0.201 0.254 B 310.0 287.0 18 30 25 5 [[478, 756]] 1.0 5am7 TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWKA P11362 458 764 822.0 66T:60801 Type1 Inactive DFGin 5.334 13.4485 BLAplus -119.61, 171.78 43.5, 42.06 -91.27, -13.97 55.41, 85.99 -97.85, 1.35 in-in in 8.3001 Saltbr-in 2.8581 HRD-in -72.97, -43.98 66.64, 7.94 in-out-out SNCioo out-out ActLoopNT-out 7.6119 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -132.9, 130.16 APE9-dihe-in -81.93, 117.68 APE8-dihe-out -73.74, -2.4 APE8-rot-na 340.19 APE67-dihe-in -78.12, -6.2 -84.98, -15.3 APE12-dist-na 17.0094 APE11-dist-na 18.9505 APE10-dist-na 16.7093 APE9-dist-out 11.0044 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 A 317.0 307.0 0 30 30 0 [[478, 756]] 1.0 4rwk TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4ZSAA P11362 464 765 822.0 4UT:801 Type1 Inactive DFGin 5.2357 13.3584 BLAplus -116.62, 164.17 62.61, 38.9 -97.55, -0.8 57.69, 84.31 -93.9, -12.07 in-in in 7.7271 Saltbr-in 3.0735 HRD-in -75.4, -51.03 78.41, -18.38 in-out-out SNCioo out-out ActLoopNT-out 7.8014 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.19, 166.07 APE9-dihe-in -106.61, 111.7 APE8-dihe-out -53.66, -24.02 APE8-rot-na 328.26 APE67-dihe-in -75.2, -3.02 -58.56, -21.55 APE12-dist-na 20.9966 APE11-dist-na 22.3196 APE10-dist-na 20.7954 APE9-dist-out 11.8029 C488A,C584S None None XRAY 2.0 0.206 0.254 A 308.0 290.0 12 30 30 0 [[478, 756]] 1.0 4zsa TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4ZSAB P11362 462 761 822.0 4UT:801 Type1 Inactive DFGin 5.3779 12.914 BLAplus -118.54, 160.55 64.46, 37.46 -95.07, -9.43 54.72, 89.6 -73.6, -19.27 in-in in 7.6413 Saltbr-in 3.1631 HRD-in -75.52, -45.77 74.73, -25.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.36, 172.16 APE9-dihe-in -104.52, 114.27 APE8-dihe-out -53.39, -26.0 APE8-rot-na 330.81 APE67-dihe-in -73.62, -3.9 -59.13, -21.5 APE12-dist-na 20.7248 APE11-dist-na 22.162 APE10-dist-na 20.8587 APE9-dist-out 11.5249 C488A,C584S None None XRAY 2.0 0.206 0.254 B 308.0 282.0 18 30 24 6 [[478, 756]] 1.0 4zsa TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5Z0SA P11362 464 762 822.0 960:801 Type1 Inactive DFGin 5.1257 13.6012 BLAplus -107.75, 154.51 67.56, 21.06 -67.0, -16.05 58.84, 83.24 -104.7, 10.76 in-in in 8.0938 Saltbr-in 2.7426 HRD-in -68.85, -52.46 79.64, -4.73 in-out-out SNCioo out-out ActLoopNT-out 8.7089 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -91.28, 165.51 APE9-dihe-in -109.21, 113.36 APE8-dihe-out -56.28, -24.44 APE8-rot-na 329.92 APE67-dihe-in -71.21, -1.87 -54.7, -23.75 APE12-dist-na 19.955 APE11-dist-na 21.515 APE10-dist-na 19.768 APE9-dist-out 11.9765 C488A,C584S None None XRAY 2.45 0.227 0.275 A 308.0 285.0 14 30 30 0 [[478, 756]] 1.0 5z0s TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5Z0SB P11362 464 761 822.0 960:801 Type1 Inactive DFGin 5.1968 13.4303 BLAplus -118.1, 161.06 54.97, 27.99 -69.34, -31.76 53.53, 89.4 -87.91, 8.99 in-in in 7.9457 Saltbr-in 2.9791 HRD-in -70.36, -53.32 74.41, -8.98 in-out-out SNCioo out-out ActLoopNT-out 8.8736 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.22, 166.31 APE9-dihe-in -107.5, 114.63 APE8-dihe-out -57.82, -27.73 APE8-rot-na 335.53 APE67-dihe-in -71.06, -7.47 -49.72, -27.2 APE12-dist-na 19.5916 APE11-dist-na 21.3902 APE10-dist-na 19.7826 APE9-dist-out 11.7613 C488A,C584S None None XRAY 2.45 0.227 0.275 B 308.0 281.0 17 30 29 1 [[478, 756]] 1.0 5z0s TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6ITJA P11362 464 765 822.0 AXU:801 Type1 Inactive DFGin 5.0303 13.7907 BLAplus -109.33, 156.39 67.34, 25.69 -70.89, -16.74 55.89, 87.5 -104.45, 10.23 in-in in 8.0335 Saltbr-in 2.7568 HRD-in -71.81, -52.98 81.18, -14.83 in-out-out SNCioo out-out ActLoopNT-out 8.7171 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.06, 160.2 APE9-dihe-in -100.03, 111.11 APE8-dihe-out -53.01, -25.62 APE8-rot-na 330.27 APE67-dihe-in -75.62, -3.59 -58.81, -16.58 APE12-dist-na 19.4597 APE11-dist-na 21.0204 APE10-dist-na 19.4647 APE9-dist-out 11.7727 C488A,C584S None None XRAY 1.994 0.201 0.244 A 308.0 290.0 12 30 30 0 [[478, 756]] 1.0 6itj TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6ITJB P11362 459 761 822.0 AXU:801 Type1 Inactive DFGin 5.2791 13.6611 BLAplus -115.06, 158.21 61.95, 30.4 -73.56, -20.55 53.39, 86.78 -101.45, 8.81 in-in in 7.8577 Saltbr-in 2.7842 HRD-in -74.1, -50.66 79.66, -17.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.82, 164.92 APE9-dihe-in -97.18, 112.3 APE8-dihe-out -56.27, -24.59 APE8-rot-na 332.48 APE67-dihe-in -69.44, -5.6 -58.71, -22.22 APE12-dist-na 19.4677 APE11-dist-na 21.0221 APE10-dist-na 19.8073 APE9-dist-out 11.6524 C488A,C584S None None XRAY 1.994 0.201 0.244 B 308.0 293.0 10 30 25 5 [[478, 756]] 1.0 6itj TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 9CD5A P11362 465 764 822.0 A1AV2:903 Type1 Inactive DFGin 5.1092 13.0413 BLAplus -119.69, 171.16 42.37, 48.64 -93.51, -18.78 55.6, 81.67 -108.27, 19.83 in-in in 7.6418 Saltbr-in 3.4001 HRD-in -70.51, -58.43 92.5, -15.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -123.63, 147.65 APE9-dihe-in -93.38, 113.67 APE8-dihe-out -55.42, -20.8 APE8-rot-na 334.26 APE67-dihe-in -78.47, -7.11 -58.87, -20.29 APE12-dist-na 21.398 APE11-dist-na 21.2383 APE10-dist-na 19.5201 APE9-dist-out 11.6083 C488A,C584S None None XRAY 2.939 0.215 0.263 A 308.0 281.0 19 30 24 6 [[478, 756]] 1.0 9cd5 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 9CD5B P11362 460 764 822.0 A1AV2:902 Type1 Inactive DFGin 5.1115 12.7756 BLAplus -119.68, 169.96 44.78, 47.92 -93.2, -18.16 54.47, 80.79 -103.83, 15.64 in-in in 7.5897 Saltbr-in 3.2422 HRD-in -70.44, -57.93 92.25, -15.3 in-out-out SNCioo out-out ActLoopNT-out 7.9791 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.57, 148.55 APE9-dihe-in -93.36, 113.84 APE8-dihe-out -53.62, -20.73 APE8-rot-na 332.43 APE67-dihe-in -77.99, -7.05 -59.24, -19.94 APE12-dist-na 21.0098 APE11-dist-na 20.993 APE10-dist-na 19.181 APE9-dist-out 11.5839 C488A,C584S None None XRAY 2.939 0.215 0.263 B 308.0 289.0 16 30 28 2 [[478, 756]] 1.0 9cd5 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4F63A P11362 464 762 822.0 0S7:801 Type1 Inactive DFGin 5.2725 13.2273 BLAplus -123.63, 158.75 70.08, 13.43 -68.79, -20.53 59.97, 88.79 -95.8, 8.85 in-in in 7.5241 Saltbr-in 3.2319 HRD-in -74.6, -50.94 76.01, -22.74 in-out-out SNCioo out-out ActLoopNT-out 8.9744 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -83.88, 159.94 APE9-dihe-in -104.27, 121.64 APE8-dihe-out -54.29, -35.97 APE8-rot-na 333.58 APE67-dihe-in -71.9, -7.89 -48.05, -24.06 APE12-dist-na 19.824 APE11-dist-na 21.2942 APE10-dist-na 19.4902 APE9-dist-out 11.8024 C488A,C584S None None XRAY 2.55 0.232 0.287 A 309.0 278.0 21 30 30 0 [[478, 756]] 1.0 4f63 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4F63B P11362 461 761 822.0 0S7:801 Type1 Inactive DFGin 5.1074 12.5898 BLAplus -103.1, 171.09 57.7, 19.47 -72.81, -17.05 60.59, 83.16 -102.04, 8.53 in-none in 7.7314 Saltbr-none 999.0 HRD-in -67.88, -51.25 73.72, -23.66 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.49, 174.14 APE9-dihe-in -102.48, 111.01 APE8-dihe-out -53.24, -29.21 APE8-rot-na 329.82 APE67-dihe-in -68.76, -1.69 -49.63, -27.49 APE12-dist-na 999.0 APE11-dist-na 20.7796 APE10-dist-na 19.7707 APE9-dist-out 11.499 C488A,C584S None None XRAY 2.55 0.232 0.287 B 309.0 271.0 30 30 21 9 [[478, 756]] 1.0 4f63 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4F64A P11362 464 762 822.0 0S8:801 Type1 Inactive DFGin 5.1832 13.1182 BLAplus -126.63, 159.8 67.66, 19.43 -73.38, -15.37 61.14, 82.05 -112.05, 14.31 in-in in 7.8334 Saltbr-in 2.6567 HRD-in -75.01, -53.26 79.37, -13.8 in-out-out SNCioo out-out ActLoopNT-out 8.8889 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.36, 162.32 APE9-dihe-in -110.59, 112.62 APE8-dihe-out -54.21, -21.82 APE8-rot-na 334.94 APE67-dihe-in -73.68, -4.51 -58.01, -22.74 APE12-dist-na 19.9252 APE11-dist-na 21.6236 APE10-dist-na 19.6065 APE9-dist-out 11.7397 C488A,C584S None None XRAY 2.05 0.217 0.269 A 309.0 278.0 21 30 30 0 [[478, 756]] 1.0 4f64 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4F64B P11362 461 761 822.0 0S8:801 Type1 Inactive DFGin 5.1666 12.9047 BLAplus -128.73, 164.19 64.4, 29.6 -84.21, -15.05 59.33, 82.94 -106.3, 1.28 in-in in 7.8942 Saltbr-in 2.8638 HRD-in -73.33, -50.22 71.98, 0.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.2, 170.72 APE9-dihe-in -106.18, 108.15 APE8-dihe-out -52.36, -27.43 APE8-rot-na 328.0 APE67-dihe-in -80.92, -6.4 -55.61, -16.72 APE12-dist-na 999.0 APE11-dist-na 20.9952 APE10-dist-na 19.8534 APE9-dist-out 11.5563 C488A,C584S None None XRAY 2.05 0.217 0.269 B 309.0 272.0 29 30 21 9 [[478, 756]] 1.0 4f64 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4NKAA P11362 464 765 822.0 2K7:805 Type1 Inactive DFGin 5.4599 12.8303 BLAplus -109.75, 172.82 48.9, 35.6 -81.04, -25.72 46.07, 87.87 -114.73, 999.0 in-none in 7.7564 Saltbr-none 999.0 HRD-in -68.09, -53.27 80.47, -22.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.83, 157.85 APE9-dihe-in -101.57, 110.94 APE8-dihe-out -54.92, -24.59 APE8-rot-na 334.91 APE67-dihe-in -67.94, -8.42 -53.61, -27.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.5699 C488A,C584S None None XRAY 2.19 0.2 0.228 A 309.0 279.0 23 30 23 7 [[478, 756]] 1.0 4nka TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4NKSA P11362 465 762 822.0 2M2:801 Type1 Inactive DFGin 5.6302 13.8089 BLAplus -128.87, 161.68 65.74, 29.25 -87.1, -15.4 56.23, 91.24 -92.95, -7.65 in-in in 7.8964 Saltbr-in 3.034 HRD-in -61.09, -57.02 76.92, -17.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.5, 152.38 APE9-dihe-in -96.93, 124.37 APE8-dihe-out -60.38, -26.39 APE8-rot-na 339.01 APE67-dihe-in -76.01, -5.61 -56.44, -21.34 APE12-dist-na 20.0116 APE11-dist-na 21.7204 APE10-dist-na 19.6876 APE9-dist-out 11.7093 C488A,C584S None None XRAY 2.5 0.223 0.278 A 309.0 265.0 33 30 24 6 [[478, 756]] 1.0 4nks TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4NKSB P11362 461 761 822.0 2M2:801 Type1 Inactive DFGin 5.4695 13.0819 BLAplus -121.26, 176.2 65.04, 19.79 -85.17, -9.87 56.43, 80.08 -103.8, -4.05 in-in in 7.8089 Saltbr-in 3.2276 HRD-in -66.41, -53.36 81.34, -22.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.88, 166.85 APE9-dihe-in -99.02, 113.91 APE8-dihe-out -58.98, -23.63 APE8-rot-na 332.76 APE67-dihe-in -64.8, 1.58 -54.87, -32.1 APE12-dist-na 999.0 APE11-dist-na 20.7252 APE10-dist-na 19.5363 APE9-dist-out 11.7273 C488A,C584S None None XRAY 2.5 0.223 0.278 B 309.0 271.0 30 30 21 9 [[478, 756]] 1.0 4nks TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4UWBA P11362 464 765 822.0 JVT:1769 Type1 Inactive DFGin 5.3164 13.2986 BLAplus -113.09, 161.83 71.69, 23.97 -88.05, -18.23 56.26, 82.28 -95.96, 11.67 in-in in 7.8734 Saltbr-in 2.7255 HRD-in -67.29, -55.31 79.69, -18.23 in-out-out SNCioo out-out ActLoopNT-out 8.9608 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 154.4 APE9-dihe-in -93.53, 118.15 APE8-dihe-out -56.85, -29.21 APE8-rot-na 332.74 APE67-dihe-in -81.26, -7.02 -49.23, -21.08 APE12-dist-na 19.6917 APE11-dist-na 21.3819 APE10-dist-na 19.6057 APE9-dist-out 11.7811 C488A,C584S None None XRAY 2.31 0.231 0.272 A 309.0 299.0 3 30 29 1 [[478, 756]] 1.0 4uwb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4UWBB P11362 459 765 822.0 JVT:1768 Type1 Inactive DFGin 5.4368 13.0303 BLAplus -114.82, 162.53 65.13, 21.85 -74.05, -17.91 55.13, 90.89 -100.48, 4.93 in-in in 7.8876 Saltbr-in 2.7084 HRD-in -76.21, -52.64 84.1, -25.36 in-out-out SNCioo out-out ActLoopNT-out 7.9333 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.09, 162.16 APE9-dihe-in -103.08, 113.2 APE8-dihe-out -55.06, -17.49 APE8-rot-na 323.82 APE67-dihe-in -71.23, -5.74 -60.29, -25.5 APE12-dist-na 20.0048 APE11-dist-na 21.3879 APE10-dist-na 19.8969 APE9-dist-out 11.5965 C488A,C584S None None XRAY 2.31 0.231 0.272 B 309.0 299.0 8 30 27 3 [[478, 756]] 1.0 4uwb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4UWCA P11362 465 765 822.0 4Y0:1773 Type1 Inactive DFGin 5.1849 13.2183 BLAplus -114.28, 167.51 64.08, 17.08 -73.37, -20.76 56.56, 86.09 -95.43, 0.2 in-in in 7.6658 Saltbr-in 2.7686 HRD-in -68.21, -55.41 81.81, -19.33 in-out-out SNCioo out-out ActLoopNT-out 8.0095 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.15, 154.48 APE9-dihe-in -99.31, 111.29 APE8-dihe-out -53.23, -22.86 APE8-rot-na 338.31 APE67-dihe-in -68.82, -8.72 -56.37, -24.16 APE12-dist-na 20.301 APE11-dist-na 21.1983 APE10-dist-na 19.3787 APE9-dist-out 11.7572 C488A,C584S None None XRAY 1.96 0.179 0.206 A 309.0 301.0 0 30 30 0 [[478, 756]] 1.0 4uwc TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4UWCB P11362 459 764 822.0 4Y0:1770 Type1 Inactive DFGin 5.2203 13.0219 BLAplus -114.0, 163.28 67.1, 18.57 -73.54, -21.45 56.42, 85.19 -95.52, -0.76 in-in in 7.5903 Saltbr-in 2.9197 HRD-in -68.93, -54.08 82.79, -14.74 in-out-out SNCioo out-out ActLoopNT-out 8.3432 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.38, 156.7 APE9-dihe-in -100.76, 111.03 APE8-dihe-out -54.68, -24.33 APE8-rot-na 334.31 APE67-dihe-in -64.61, -11.0 -54.66, -28.32 APE12-dist-na 20.0881 APE11-dist-na 21.1466 APE10-dist-na 19.4809 APE9-dist-out 11.7331 C488A,C584S None None XRAY 1.96 0.179 0.206 B 309.0 301.0 5 30 30 0 [[478, 756]] 1.0 4uwc TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5O49A P11362 464 764 822.0 9K5:801 Type1 Inactive DFGin 5.2397 13.6382 BLAplus -124.98, 161.58 68.85, 20.17 -74.75, -11.05 61.69, 77.84 -110.93, 4.69 in-out in 8.1254 Saltbr-out 5.5459 HRD-in -64.73, -48.02 76.28, -6.18 out-out-out SNCooo out-out ActLoopNT-out 8.7824 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.25, 168.76 APE9-dihe-in -119.19, 119.01 APE8-dihe-out -64.8, -20.97 APE8-rot-na 343.93 APE67-dihe-in -73.72, -10.74 -55.47, -23.05 APE12-dist-na 19.5652 APE11-dist-na 21.14 APE10-dist-na 19.4995 APE9-dist-out 11.833 C488A,C584S None None XRAY 1.91 0.2 0.22 A 309.0 289.0 12 30 30 0 [[478, 756]] 1.0 5o49 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5O49B P11362 460 765 822.0 9K5:801 Type1 Inactive DFGin 5.6188 12.9288 BLAplus -126.58, 172.58 67.38, 24.13 -84.06, -18.33 50.82, 87.05 -104.51, 13.86 in-out in 7.6377 Saltbr-out 4.5004 HRD-in -61.81, -47.66 75.62, -5.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.43, 163.49 APE9-dihe-in -105.31, 114.78 APE8-dihe-out -56.47, -25.97 APE8-rot-na 333.8 APE67-dihe-in -70.86, -8.05 -56.14, -23.8 APE12-dist-na 19.0124 APE11-dist-na 20.4124 APE10-dist-na 18.7866 APE9-dist-out 11.7226 C488A,C584S None None XRAY 1.91 0.2 0.22 B 309.0 286.0 20 30 25 5 [[478, 756]] 1.0 5o49 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5O4AA P11362 464 764 822.0 9K8:804 Type1 Inactive DFGin 5.4116 13.5446 BLAplus -122.09, 166.75 52.86, 39.44 -89.66, -24.51 52.16, 85.77 -93.11, 3.02 in-out in 7.9213 Saltbr-out 5.7074 HRD-in -69.28, -47.39 73.72, -11.63 out-out-out SNCooo out-out ActLoopNT-out 8.755 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.02, 156.72 APE9-dihe-in -102.28, 120.59 APE8-dihe-out -56.89, -30.5 APE8-rot-na 333.66 APE67-dihe-in -72.75, -8.94 -55.59, -20.78 APE12-dist-na 20.0842 APE11-dist-na 21.4594 APE10-dist-na 19.6526 APE9-dist-out 11.8991 None None None XRAY 2.01 0.217 0.225 A 309.0 290.0 11 30 30 0 [[478, 756]] 1.0 5o4a TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5O4AB P11362 460 763 822.0 9K8:802 Type1 Inactive DFGin 5.5206 13.0943 BLAplus -119.73, 164.81 56.03, 47.68 -94.68, -27.26 47.68, 87.08 -89.69, 6.98 in-out in 7.7343 Saltbr-out 4.1087 HRD-in -64.38, -47.45 77.25, -12.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.24, 154.27 APE9-dihe-in -101.59, 121.81 APE8-dihe-out -57.48, -31.39 APE8-rot-na 330.82 APE67-dihe-in -66.62, 0.37 -53.02, -29.01 APE12-dist-na 20.0179 APE11-dist-na 21.0494 APE10-dist-na 19.1025 APE9-dist-out 11.7028 None None None XRAY 2.01 0.217 0.225 B 309.0 291.0 13 30 25 5 [[478, 756]] 1.0 5o4a TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7OZBAAA P11362 464 765 822.0 47I:801 Type1 Inactive DFGin 5.1652 13.2255 BLAplus -113.5, 164.02 64.24, 28.44 -81.1, -17.3 55.31, 86.35 -99.81, -4.02 in-in in 7.6783 Saltbr-in 3.0354 HRD-in -68.22, -55.33 81.75, -15.47 in-out-out SNCioo out-out ActLoopNT-out 8.6293 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.53, 159.74 APE9-dihe-in -101.43, 112.26 APE8-dihe-out -54.35, -25.93 APE8-rot-na 332.55 APE67-dihe-in -70.65, -7.52 -55.15, -25.11 APE12-dist-na 19.2916 APE11-dist-na 20.7453 APE10-dist-na 19.1948 APE9-dist-out 11.6637 C488A,C584S None None XRAY 1.71 0.211 0.244 AAA 309.0 288.0 14 30 30 0 [[478, 756]] 1.0 7ozb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7OZBBBB P11362 460 764 822.0 47I:801 Type1 Inactive DFGin 5.2201 12.8529 BLAplus -116.55, 158.6 67.07, 25.64 -79.35, -20.91 57.12, 84.44 -89.98, -6.37 in-in in 7.6315 Saltbr-in 2.9829 HRD-in -68.5, -59.33 86.86, -18.0 in-out-out SNCioo out-out ActLoopNT-out 8.1932 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.69, 159.38 APE9-dihe-in -99.92, 110.92 APE8-dihe-out -56.91, -22.49 APE8-rot-na 333.27 APE67-dihe-in -69.35, -9.22 -56.3, -24.07 APE12-dist-na 19.5566 APE11-dist-na 20.9014 APE10-dist-na 19.3195 APE9-dist-out 11.5573 C488A,C584S None None XRAY 1.71 0.211 0.244 BBB 309.0 291.0 14 30 30 0 [[478, 756]] 1.0 7ozb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7OZDAAA P11362 464 765 822.0 42I:801 Type1 Inactive DFGin 5.1891 13.3222 BLAplus -116.42, 163.08 62.72, 27.25 -80.95, -15.5 58.36, 83.15 -93.3, -6.95 in-in in 7.6994 Saltbr-in 2.8847 HRD-in -70.31, -57.17 82.73, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.1, 157.43 APE9-dihe-in -99.3, 111.88 APE8-dihe-out -57.0, -23.76 APE8-rot-na 335.77 APE67-dihe-in -73.24, -6.2 -56.45, -22.92 APE12-dist-na 20.0675 APE11-dist-na 21.4554 APE10-dist-na 19.818 APE9-dist-out 11.756 C488A,C584S None None XRAY 1.82 0.201 0.241 AAA 309.0 282.0 20 30 24 6 [[478, 756]] 1.0 7ozd TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7OZDBBB P11362 460 763 822.0 42I:801 Type1 Inactive DFGin 5.2176 12.8672 BLAplus -120.15, 162.48 66.77, 26.73 -83.0, -17.85 57.88, 82.23 -92.89, -7.69 in-in in 7.5473 Saltbr-in 2.9696 HRD-in -73.06, -57.3 87.17, -16.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -111.05, 157.78 APE9-dihe-in -98.55, 112.28 APE8-dihe-out -56.64, -24.18 APE8-rot-na 331.82 APE67-dihe-in -72.02, -11.22 -53.55, -23.65 APE12-dist-na 19.616 APE11-dist-na 20.9379 APE10-dist-na 19.3656 APE9-dist-out 11.5993 C488A,C584S None None XRAY 1.82 0.201 0.241 BBB 309.0 285.0 19 30 25 5 [[478, 756]] 1.0 7ozd TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7OZFAAA P11362 465 765 822.0 466:801 Type1 Inactive DFGin 5.2955 13.468 BLAplus -117.68, 161.62 66.46, 36.41 -95.38, -7.29 57.95, 82.09 -95.91, -11.26 in-in in 7.8017 Saltbr-in 3.0344 HRD-in -74.16, -54.6 82.1, -14.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 162.73 APE9-dihe-in -101.57, 112.99 APE8-dihe-out -53.92, -25.84 APE8-rot-na 335.55 APE67-dihe-in -73.42, -8.15 -56.91, -22.71 APE12-dist-na 20.3344 APE11-dist-na 21.6782 APE10-dist-na 20.2 APE9-dist-out 11.7273 None None None XRAY 1.82 0.206 0.242 AAA 309.0 288.0 13 30 25 5 [[478, 756]] 1.0 7ozf TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7OZFBBB P11362 460 763 822.0 466:801 Type1 Inactive DFGin 5.2534 13.0233 BLAplus -116.0, 158.26 69.37, 33.48 -90.88, -17.29 57.42, 83.97 -77.99, -12.47 in-in in 7.6429 Saltbr-in 2.9656 HRD-in -73.91, -57.88 84.04, -15.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.71, 160.57 APE9-dihe-in -98.6, 110.79 APE8-dihe-out -55.8, -24.65 APE8-rot-na 332.84 APE67-dihe-in -74.09, -8.17 -55.72, -20.54 APE12-dist-na 20.458 APE11-dist-na 21.8593 APE10-dist-na 20.1777 APE9-dist-out 11.6515 None None None XRAY 1.82 0.206 0.242 BBB 309.0 282.0 22 30 25 5 [[478, 756]] 1.0 7ozf TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 1AGWA P11362 464 762 822.0 SU2:1001 Type1 Inactive DFGin 5.274 13.3892 BLAplus -121.22, 164.09 62.54, 22.82 -75.41, -18.74 57.89, 80.74 -105.07, 9.46 in-out in 7.7097 Saltbr-out 3.8446 HRD-in -69.09, -52.68 78.93, -10.47 out-out-out SNCooo out-out ActLoopNT-out 9.0718 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.44, 164.07 APE9-dihe-in -103.49, 105.01 APE8-dihe-out -48.23, -28.22 APE8-rot-na 326.86 APE67-dihe-in -79.1, -0.7 -60.74, -14.06 APE12-dist-na 19.7105 APE11-dist-na 20.8726 APE10-dist-na 19.2569 APE9-dist-out 11.9035 None None None XRAY 2.4 0.194 0.28 A 310.0 278.0 21 30 30 0 [[478, 756]] 1.0 1agw TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 1AGWB P11362 461 761 822.0 SU2:1000 Type1 Inactive DFGin 5.1047 12.9272 BLAplus -118.48, 160.09 61.53, 23.36 -75.62, -9.51 55.77, 89.71 -113.95, 12.53 in-in in 7.7742 Saltbr-in 2.9735 HRD-in -65.85, -35.14 62.11, -1.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.88, 159.91 APE9-dihe-in -102.85, 114.8 APE8-dihe-out -54.83, -28.49 APE8-rot-na 327.14 APE67-dihe-in -71.12, -9.61 -53.83, -20.83 APE12-dist-na 999.0 APE11-dist-na 21.087 APE10-dist-na 19.5591 APE9-dist-out 11.7943 C488A None None XRAY 2.4 0.194 0.28 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 1agw TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 1FGIA P11362 464 762 822.0 SU1:1001 Type1 Inactive DFGin 5.2448 13.0507 BLAplus -118.43, 166.43 66.52, 8.73 -64.13, -34.61 60.57, 85.04 -94.1, 14.31 in-out in 7.8098 Saltbr-out 4.3938 HRD-in -65.25, -56.3 86.33, -6.46 out-out-out SNCooo out-out ActLoopNT-out 9.0188 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.01, 168.11 APE9-dihe-in -109.23, 108.22 APE8-dihe-out -49.03, -28.53 APE8-rot-na 326.13 APE67-dihe-in -78.81, -8.46 -60.3, -12.78 APE12-dist-na 19.4008 APE11-dist-na 20.9219 APE10-dist-na 19.2133 APE9-dist-out 11.7398 C488A None None XRAY 2.5 0.19 0.27 A 310.0 283.0 16 30 30 0 [[478, 756]] 1.0 1fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 1FGIB P11362 461 761 822.0 SU1:1000 Type1 Inactive DFGin 5.0855 12.8872 BLAplus -129.12, 161.76 68.96, 4.34 -61.61, -28.72 62.68, 83.75 -98.14, 18.47 in-in in 7.9774 Saltbr-in 3.237 HRD-in -67.23, -42.86 65.67, 6.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.03, 163.6 APE9-dihe-in -107.58, 116.43 APE8-dihe-out -54.66, -25.86 APE8-rot-na 323.83 APE67-dihe-in -66.67, -9.45 -56.63, -25.45 APE12-dist-na 999.0 APE11-dist-na 21.117 APE10-dist-na 19.5572 APE9-dist-out 11.7854 C488A None None XRAY 2.5 0.19 0.27 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 1fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5AM6A P11362 458 765 822.0 38O:61766 Type1 Inactive DFGin 5.201 13.2703 BLAplus -112.58, 159.52 61.38, 32.49 -78.96, -18.15 54.05, 84.03 -102.14, 12.3 in-in in 7.7152 Saltbr-in 3.2516 HRD-in -73.83, -55.77 84.43, -16.37 in-out-out SNCioo out-out ActLoopNT-out 8.7281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.68, 158.35 APE9-dihe-in -101.09, 116.06 APE8-dihe-out -55.18, -24.78 APE8-rot-na 339.12 APE67-dihe-in -70.49, -7.18 -57.16, -24.6 APE12-dist-na 19.7602 APE11-dist-na 21.181 APE10-dist-na 19.8607 APE9-dist-out 11.7652 None None None XRAY 1.96 0.216 0.252 A 310.0 294.0 14 30 30 0 [[478, 756]] 1.0 5am6 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5AM6B P11362 458 762 822.0 38O:61763 Type1 Inactive DFGin 5.2795 13.0402 BLAplus -109.26, 159.81 58.35, 42.16 -91.18, -11.81 51.78, 82.49 -107.62, 15.27 in-in in 7.6454 Saltbr-in 3.4946 HRD-in -73.63, -54.03 80.88, -21.94 in-out-out SNCioo out-out ActLoopNT-out 8.6147 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.73, 157.38 APE9-dihe-in -92.88, 109.99 APE8-dihe-out -51.36, -29.92 APE8-rot-na 334.27 APE67-dihe-in -70.82, -6.38 -56.34, -19.57 APE12-dist-na 999.0 APE11-dist-na 21.1311 APE10-dist-na 19.7444 APE9-dist-out 11.6365 None None None XRAY 1.96 0.216 0.252 B 310.0 280.0 25 30 17 13 [[478, 756]] 1.0 5am6 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5UQ0A P11362 464 765 822.0 WP1:801 Type1 Inactive DFGin 5.2233 13.3452 BLAplus -129.51, 154.04 71.7, 22.04 -75.61, 2.54 58.4, 85.52 -125.18, 1.34 in-none in 7.8436 Saltbr-none 999.0 HRD-in -67.62, -52.6 81.66, -15.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 93.59 APE8-dihe-out -63.72, -18.01 APE8-rot-na 26.7 APE67-dihe-in -66.9, -7.24 -49.77, -36.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2474 C488A,C584S None None XRAY 2.3 0.237 0.294 A 311.0 266.0 36 30 13 17 [[478, 756]] 1.0 5uq0 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5UQ0B P11362 463 762 822.0 WP1:801 Type1 Inactive DFGin 5.252 13.1182 BLAplus -135.89, 161.84 57.67, 28.98 -76.93, -27.79 58.9, 86.78 -79.34, -7.22 in-in in 8.18 Saltbr-in 2.6375 HRD-in -67.2, -48.58 76.55, -0.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -106.5 APE8-dihe-out -49.01, -32.28 APE8-rot-na 23.14 APE67-dihe-in -80.37, 4.41 -44.32, -39.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.0692 C488A,C584S None None XRAY 2.3 0.237 0.294 B 311.0 256.0 44 30 13 17 [[478, 756]] 1.0 5uq0 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3JS2A P11362 464 765 822.0 VM1:801 Type1 Inactive DFGin 5.153 13.3035 BLAplus -121.66, 167.26 60.21, 27.33 -82.6, -17.8 54.2, 84.02 -103.88, 10.59 in-in in 7.7242 Saltbr-in 3.0512 HRD-in -72.72, -56.56 85.97, -17.24 in-out-out SNCioo out-out ActLoopNT-out 7.9689 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.37, 154.98 APE9-dihe-in -92.36, 117.27 APE8-dihe-out -54.75, -26.7 APE8-rot-na 329.63 APE67-dihe-in -71.32, -6.64 -59.57, -19.47 APE12-dist-na 19.1598 APE11-dist-na 20.7834 APE10-dist-na 19.3186 APE9-dist-out 11.8143 C488A,C584S None None XRAY 2.2 0.216 0.259 A 317.0 295.0 7 30 30 0 [[478, 756]] 1.0 3js2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3JS2B P11362 459 762 822.0 VM1:801 Type1 Inactive DFGin 5.166 12.9148 BLAplus -117.79, 168.89 57.38, 26.57 -81.81, -21.58 58.31, 81.41 -101.15, 4.46 in-in in 7.4152 Saltbr-in 2.8977 HRD-in -70.61, -55.45 85.21, -19.22 in-out-out SNCioo out-out ActLoopNT-out 8.3884 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.77, 164.88 APE9-dihe-in -101.88, 109.77 APE8-dihe-out -47.5, -33.8 APE8-rot-na 323.58 APE67-dihe-in -71.37, -10.85 -58.97, -16.94 APE12-dist-na 19.4281 APE11-dist-na 20.9341 APE10-dist-na 19.561 APE9-dist-out 11.7757 C488A,C584S None None XRAY 2.2 0.216 0.259 B 317.0 291.0 13 30 30 0 [[478, 756]] 1.0 3js2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3GQLC P11362 463 766 822.0 GQL:1 Type1 Inactive DFGin 5.708 13.0273 BLAplus -123.78, 172.03 54.97, 32.17 -87.82, -13.88 53.39, 70.63 -108.09, 38.81 in-in in 7.8051 Saltbr-in 2.6157 HRD-in -59.51, -40.97 72.56, -22.95 in-out-none SNCion out-none ActLoopNT-out 8.7583 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.55 APE8-rot-na 32.95 APE67-dihe-in -61.65, -18.42 -80.52, -27.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 C 326.0 275.0 29 30 14 16 [[478, 756]] 1.0 3gql TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8JMZA P11362 460 765 822.0 UKI:60801 Type1 Inactive DFGin 5.1589 13.2886 BLAplus -113.58, 162.96 62.0, 28.58 -83.36, -13.84 56.58, 89.17 -102.65, 12.75 in-in in 7.8587 Saltbr-in 2.8351 HRD-in -72.3, -51.47 78.17, -4.24 in-out-out SNCioo out-out ActLoopNT-out 7.9805 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.22, 148.56 APE9-dihe-in -107.32, 99.52 APE8-dihe-out -56.46, -18.86 APE8-rot-na 328.17 APE67-dihe-in -74.96, -9.03 -56.04, -27.86 APE12-dist-na 16.4248 APE11-dist-na 18.9969 APE10-dist-na 16.2227 APE9-dist-out 11.0211 C584S None None XRAY 1.988 0.166 0.205 A 310.0 306.0 0 30 30 0 [[478, 756]] 1.0 8jmz TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8JMZB P11362 458 763 822.0 UKI:60801 Type1 Inactive DFGin 5.259 13.0071 BLAplus -114.88, 158.62 61.68, 33.22 -84.25, -18.02 53.38, 88.43 -92.93, -0.34 in-in in 7.7668 Saltbr-in 2.9243 HRD-in -72.45, -50.78 74.31, -4.23 in-out-out SNCioo out-out ActLoopNT-out 8.3535 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.73, 168.34 APE9-dihe-in -103.17, 113.28 APE8-dihe-out -51.14, -25.22 APE8-rot-na 328.21 APE67-dihe-in -74.28, -2.47 -57.8, -24.89 APE12-dist-na 20.439 APE11-dist-na 21.4008 APE10-dist-na 20.0649 APE9-dist-out 11.5011 C584S None None XRAY 1.988 0.166 0.205 B 310.0 290.0 16 30 27 3 [[478, 756]] 1.0 8jmz TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 9UHCA P11362 458 764 822.0 A1EPE:60801 Type1 Inactive DFGin 5.0891 13.5661 BLAplus -99.26, 163.63 67.92, 18.69 -73.13, -23.6 54.69, 89.65 -94.23, 7.24 in-in in 8.5804 Saltbr-in 2.8372 HRD-in -81.76, -52.28 81.48, -12.21 in-out-out SNCioo out-out ActLoopNT-out 7.6895 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.01, 148.62 APE9-dihe-in -107.23, 98.65 APE8-dihe-out -61.69, -18.58 APE8-rot-na 332.39 APE67-dihe-in -73.38, -10.07 -53.51, -28.36 APE12-dist-na 17.3301 APE11-dist-na 19.8276 APE10-dist-na 16.8879 APE9-dist-out 11.0839 None None None XRAY 1.88 0.173 0.205 A 310.0 307.0 0 30 30 0 [[478, 756]] 1.0 9uhc TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 9UHCB P11362 458 763 822.0 A1EPE:60801 Type1 Inactive DFGin 5.2803 12.9098 BLAplus -104.01, 159.23 73.73, 21.61 -75.73, -25.49 53.38, 87.57 -92.18, 7.01 in-in in 7.958 Saltbr-in 3.2635 HRD-in -83.66, -52.1 79.1, -13.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.36, 141.0 APE9-dihe-in -101.25, 92.23 APE8-dihe-out -59.77, -24.69 APE8-rot-na 330.6 APE67-dihe-in -77.73, -0.07 -57.66, -24.92 APE12-dist-na 17.3904 APE11-dist-na 20.1263 APE10-dist-na 17.1087 APE9-dist-out 11.2956 None None None XRAY 1.88 0.173 0.205 B 310.0 286.0 20 30 23 7 [[478, 756]] 1.0 9uhc TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 9UHIA P11362 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.4362 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.2512 Saltbr-in 2.8878 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.5114 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.6718 APE10-dist-na 16.6848 APE9-dist-out 11.0826 None None None XRAY 1.76 0.163 0.197 A 310.0 307.0 0 30 30 0 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 9UHIB P11362 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.2132 12.7377 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.7681 Saltbr-in 3.4492 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.3515 APE11-dist-na 20.6822 APE10-dist-na 16.9654 APE9-dist-out 11.3637 None None None XRAY 1.76 0.163 0.197 B 310.0 286.0 20 30 23 7 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5A46A P11362 464 766 822.0 38O:1769 Type1 Inactive DFGin 5.2132 13.149 BLAplus -118.77, 162.9 58.04, 28.78 -73.18, -26.4 58.45, 90.15 -96.03, 5.5 in-in in 7.5128 Saltbr-in 3.005 HRD-in -57.82, -48.72 70.95, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.0, 143.36 APE9-dihe-in -88.58, 110.07 APE8-dihe-out -58.5, -16.77 APE8-rot-na 337.71 APE67-dihe-in -76.67, -10.73 -63.67, -15.99 APE12-dist-na 20.0328 APE11-dist-na 21.3237 APE10-dist-na 19.4318 APE9-dist-out 12.0888 None None None XRAY 2.63 0.182 0.246 A 386.0 290.0 13 30 27 3 [[478, 756]] 1.0 5a46 TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5A46B P11362 458 766 822.0 38O:1767 Type1 Inactive DFGin 5.33 12.787 BLAplus -120.14, 161.93 66.72, 19.6 -75.13, -22.14 56.34, 83.44 -97.38, -0.25 in-in in 7.5925 Saltbr-in 2.7985 HRD-in -68.23, -43.1 73.28, -14.2 in-out-out SNCioo out-out ActLoopNT-out 7.9798 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -119.49, 150.14 APE9-dihe-in -90.22, 111.65 APE8-dihe-out -53.72, -24.65 APE8-rot-na 331.17 APE67-dihe-in -66.01, -7.4 -51.07, -30.75 APE12-dist-na 20.2916 APE11-dist-na 21.2715 APE10-dist-na 19.9075 APE9-dist-out 11.8789 None None None XRAY 2.63 0.182 0.246 B 386.0 298.0 11 30 30 0 [[478, 756]] 1.0 5a46 TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWKB P11362 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.7367 13.232 BLAplus -119.15, 169.82 41.98, 44.21 -90.47, -9.61 54.08, 84.94 -94.37, 2.45 in-in in 8.4157 Saltbr-in 3.448 HRD-in -74.45, -44.2 66.06, 8.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -133.04, 131.77 APE9-dihe-in -79.69, 122.84 APE8-dihe-out -69.38, -1.04 APE8-rot-na 339.66 APE67-dihe-in -75.83, -3.81 -84.39, -12.82 APE12-dist-na 999.0 APE11-dist-na 21.9267 APE10-dist-na 19.8348 APE9-dist-out 11.6466 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 B 317.0 282.0 23 30 23 7 [[478, 756]] 1.0 4rwk TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3C4FA P11362 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.1138 13.3182 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.8662 Saltbr-out 4.6321 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.0691 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.2924 APE11-dist-na 21.1206 APE10-dist-na 19.3954 APE9-dist-out 11.7567 C488A None None XRAY 2.07 0.213 0.264 A 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3C4FB P11362 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.1863 13.0956 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.8308 Saltbr-in 3.2478 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.9335 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.3702 APE11-dist-na 21.2959 APE10-dist-na 19.6706 APE9-dist-out 11.6434 C488A None None XRAY 2.07 0.213 0.264 B 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3RHXA P11362 464 764 822.0 3RH:2 Type1.5_Back Inactive DFGin 5.2319 13.4239 BLAplus -115.51, 162.57 65.19, 24.13 -75.33, -9.38 51.51, 92.3 -110.55, 8.31 in-in in 7.9108 Saltbr-in 2.7108 HRD-in -70.15, -54.52 80.53, -17.3 in-out-out SNCioo out-out ActLoopNT-out 8.9538 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.48, 163.59 APE9-dihe-in -103.14, 115.59 APE8-dihe-out -45.87, -31.01 APE8-rot-na 329.03 APE67-dihe-in -73.43, -8.98 -55.07, -22.7 APE12-dist-na 19.7705 APE11-dist-na 20.9378 APE10-dist-na 19.6197 APE9-dist-out 11.6966 C488A,C584S None None XRAY 2.01 0.205 0.262 A 306.0 289.0 12 30 30 0 [[478, 756]] 1.0 3rhx TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3RHXB P11362 461 761 822.0 3RH:1 Type1.5_Back Inactive DFGin 5.2781 13.0536 BLAplus -115.52, 168.31 59.14, 31.22 -88.71, -15.14 56.2, 82.95 -99.2, 10.03 in-in in 7.9397 Saltbr-in 2.9816 HRD-in -72.09, -51.52 83.53, -18.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.0, 155.03 APE9-dihe-in -98.71, 116.74 APE8-dihe-out -54.04, -23.88 APE8-rot-na 324.24 APE67-dihe-in -72.41, -9.32 -62.62, -17.17 APE12-dist-na 20.0916 APE11-dist-na 21.3945 APE10-dist-na 19.8352 APE9-dist-out 11.6213 C488A,C584S None None XRAY 2.01 0.205 0.262 B 306.0 275.0 26 30 24 6 [[478, 756]] 1.0 3rhx TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5A4CA P11362 464 765 822.0 XOJ:61774 Type1.5_Back Inactive DFGin 5.0481 13.267 BLAplus -116.37, 165.87 49.91, 42.78 -84.97, -10.47 49.36, 85.77 -124.76, 35.25 in-in in 7.785 Saltbr-in 2.7726 HRD-in -70.73, -50.48 78.51, -17.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.99, 158.13 APE9-dihe-in -97.5, 110.29 APE8-dihe-out -57.36, -20.43 APE8-rot-na 331.74 APE67-dihe-in -71.92, -10.57 -60.66, -19.9 APE12-dist-na 19.8611 APE11-dist-na 20.9953 APE10-dist-na 19.4954 APE9-dist-out 11.8058 C488A,C584S None None XRAY 2.09 0.197 0.235 A 307.0 294.0 8 30 24 6 [[478, 756]] 1.0 5a4c TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5A4CB P11362 461 765 822.0 XOJ:61772 Type1.5_Back Inactive DFGin 4.9967 13.1633 BLAplus -119.35, 160.02 53.79, 37.21 -79.91, -19.99 52.56, 81.88 -121.98, 47.25 in-in in 7.6662 Saltbr-in 2.8745 HRD-in -70.85, -51.35 80.75, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.16, 158.77 APE9-dihe-in -96.18, 111.18 APE8-dihe-out -54.21, -24.18 APE8-rot-na 331.2 APE67-dihe-in -62.46, -9.6 -52.41, -31.86 APE12-dist-na 20.0808 APE11-dist-na 21.2572 APE10-dist-na 19.71 APE9-dist-out 11.6301 C488A,C584S None None XRAY 2.09 0.197 0.235 B 307.0 284.0 21 30 25 5 [[478, 756]] 1.0 5a4c TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4NK9B P11362 460 765 822.0 2K5:802 Type1.5_Back Inactive DFGin 5.8249 13.2193 BLAplus -122.38, 146.16 46.72, 66.95 -88.33, 79.62 27.47, 86.37 49.01, 999.0 in-in in 8.0414 Saltbr-in 3.3685 HRD-in -55.1, -51.05 76.42, -8.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.43, 153.75 APE9-dihe-in -96.17, 112.02 APE8-dihe-out -57.11, -19.43 APE8-rot-na 333.43 APE67-dihe-in -71.52, -2.84 -61.88, -22.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.7726 C488A,C584S None None XRAY 2.57 0.209 0.262 B 309.0 282.0 24 30 22 8 [[478, 756]] 1.0 4nk9 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4V05A P11362 464 765 822.0 66T:1769 Type1.5_Back Inactive DFGin 5.4734 13.4201 BLAplus -110.72, 173.08 50.09, 39.57 -95.62, -19.67 60.09, 83.48 -87.99, 3.34 in-in in 8.0484 Saltbr-in 2.7499 HRD-in -64.72, -51.32 77.65, -23.6 in-out-out SNCioo out-out ActLoopNT-out 8.3021 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.91, 158.86 APE9-dihe-in -104.86, 116.5 APE8-dihe-out -57.09, -23.19 APE8-rot-na 335.63 APE67-dihe-in -66.78, -18.31 -54.95, -24.99 APE12-dist-na 20.8412 APE11-dist-na 21.8076 APE10-dist-na 19.9108 APE9-dist-out 11.6016 None None None XRAY 2.57 0.196 0.256 A 309.0 287.0 15 30 26 4 [[478, 756]] 1.0 4v05 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4V05B P11362 459 764 822.0 66T:1767 Type1.5_Back Inactive DFGin 5.4267 13.0724 BLAplus -110.08, 173.06 48.31, 47.35 -106.86, -10.85 58.74, 86.16 -77.17, -18.0 in-in in 7.8311 Saltbr-in 2.9832 HRD-in -65.29, -47.82 74.06, -21.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.03, 160.1 APE9-dihe-in -100.97, 109.95 APE8-dihe-out -53.4, -23.19 APE8-rot-na 333.98 APE67-dihe-in -59.05, -11.55 -51.93, -35.21 APE12-dist-na 21.3913 APE11-dist-na 22.0888 APE10-dist-na 20.5381 APE9-dist-out 11.4653 None None None XRAY 2.57 0.196 0.256 B 309.0 286.0 20 30 26 4 [[478, 756]] 1.0 4v05 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5EW8A P11362 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.9481 13.2646 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.9544 Saltbr-in 2.8007 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.0673 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.3705 APE11-dist-na 20.7434 APE10-dist-na 19.2162 APE9-dist-out 11.8815 None None None XRAY 1.63 0.186 0.206 A 309.0 291.0 11 30 30 0 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5EW8B P11362 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.0015 13.1238 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.8796 Saltbr-in 2.8072 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.3799 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.9019 APE11-dist-na 21.1689 APE10-dist-na 19.6545 APE9-dist-out 11.7665 None None None XRAY 1.63 0.186 0.206 B 309.0 290.0 15 30 28 2 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 2FGIA P11362 464 762 822.0 PD1:1001 Type1.5_Back Inactive DFGin 5.1208 13.4271 BLAplus -112.68, 157.47 60.87, 36.89 -81.98, -32.37 53.09, 90.73 -98.47, 17.45 in-in in 7.7469 Saltbr-in 2.9011 HRD-in -72.72, -53.18 83.95, -27.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -126.75, 157.3 APE9-dihe-in -97.93, 112.9 APE8-dihe-out -58.5, -25.56 APE8-rot-na 326.54 APE67-dihe-in -72.23, -8.06 -59.01, -20.89 APE12-dist-na 19.9221 APE11-dist-na 21.1754 APE10-dist-na 19.3215 APE9-dist-out 11.5439 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 A 310.0 274.0 25 30 28 2 [[478, 756]] 1.0 2fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 2FGIB P11362 461 761 822.0 PD1:1000 Type1.5_Back Inactive DFGin 5.0651 13.2083 BLAplus -127.21, 161.09 62.19, 18.94 -71.59, -20.95 56.29, 90.56 -106.4, 12.05 in-in in 7.7763 Saltbr-in 3.0664 HRD-in -62.08, -49.35 70.47, -0.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.38, 171.1 APE9-dihe-in -103.55, 110.23 APE8-dihe-out -52.66, -22.87 APE8-rot-na 324.05 APE67-dihe-in -65.07, -15.18 -62.56, -23.42 APE12-dist-na 999.0 APE11-dist-na 20.1947 APE10-dist-na 19.4561 APE9-dist-out 11.6548 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 2fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5B7VA P11362 464 763 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.579 13.1223 BLAplus -124.02, 164.1 56.03, 35.18 -83.98, -18.11 54.48, 82.39 -93.9, 14.98 in-in in 7.6751 Saltbr-in 3.0247 HRD-in -66.75, -56.97 82.51, -19.31 in-out-out SNCioo out-out ActLoopNT-out 8.5813 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.75, 145.14 APE9-dihe-in -88.05, 111.6 APE8-dihe-out -54.86, -24.86 APE8-rot-na 336.86 APE67-dihe-in -69.24, -8.96 -56.43, -23.01 APE12-dist-na 20.9664 APE11-dist-na 21.6298 APE10-dist-na 19.6578 APE9-dist-out 12.0193 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 A 310.0 282.0 18 30 27 3 [[478, 756]] 1.0 5b7v TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4WUNA P11362 465 765 822.0 66T:801 Type1.5_Back Inactive DFGin 5.3591 13.2871 BLAplus -114.51, 167.45 61.45, 33.19 -92.75, -3.72 56.8, 81.8 -94.63, -9.82 in-in in 7.9245 Saltbr-in 2.9429 HRD-in -77.57, -50.47 80.03, -11.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -31.68 APE8-rot-na 335.8 APE67-dihe-in -71.2, -7.75 -54.8, -30.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.65 0.226 0.247 A 311.0 282.0 19 30 12 18 [[478, 756]] 1.0 4wun TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4WUNB P11362 461 762 822.0 66T:801 Type1.5_Back Inactive DFGin 5.2393 13.1038 BLAplus -116.49, 163.26 61.87, 38.6 -99.56, -5.62 55.6, 83.98 -99.35, -2.08 in-in in 7.7038 Saltbr-in 2.6666 HRD-in -74.96, -47.89 70.35, -11.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 81.94 APE8-dihe-out -59.03, -20.07 APE8-rot-na 4.38 APE67-dihe-in -66.47, -11.9 -63.08, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2021 None None None XRAY 1.65 0.226 0.247 B 311.0 268.0 34 30 13 17 [[478, 756]] 1.0 4wun TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5UR1A P11362 464 765 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.4257 13.5195 BLAplus -105.89, 156.77 50.9, 45.08 -90.42, 1.33 56.15, 80.94 -119.23, 19.57 in-in in 8.1192 Saltbr-in 2.8741 HRD-in -68.09, -57.16 83.23, -8.89 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -37.48 APE8-rot-na 0.79 APE67-dihe-in -68.25, -11.12 -55.14, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 A 311.0 278.0 24 30 12 18 [[478, 756]] 1.0 5ur1 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C18A P11362 465 765 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.4358 13.4677 BLAplus -111.24, 164.85 45.25, 45.5 -89.65, 12.35 52.19, 85.8 -112.52, 6.73 in-in in 8.1148 Saltbr-in 2.9779 HRD-in -70.43, -53.82 83.18, -8.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.11 APE8-rot-na 0.21 APE67-dihe-in -78.22, -8.43 -50.66, -26.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 A 311.0 276.0 25 30 12 18 [[478, 756]] 1.0 6c18 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C19A P11362 464 765 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.2602 13.4424 BLAplus -115.0, 156.31 53.23, 42.1 -90.35, 7.6 54.35, 87.97 -114.31, 9.09 in-in in 7.9996 Saltbr-in 2.7593 HRD-in -69.01, -56.23 81.64, -20.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 102.7 APE8-dihe-out -60.85, -19.74 APE8-rot-na 1.27 APE67-dihe-in -75.51, -3.9 -52.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.3194 None None None XRAY 2.12 0.207 0.239 A 311.0 276.0 26 30 13 17 [[478, 756]] 1.0 6c19 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C19B P11362 464 762 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.4245 13.2752 BLAplus -112.97, 152.62 61.65, 40.35 -91.96, -0.71 58.29, 80.73 -101.35, 18.35 in-in in 7.8884 Saltbr-in 2.6766 HRD-in -74.47, -50.19 73.43, -16.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 88.31 APE8-dihe-out -50.83, -20.72 APE8-rot-na 330.47 APE67-dihe-in -67.26, -8.41 -54.06, -29.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2189 None None None XRAY 2.12 0.207 0.239 B 311.0 264.0 35 30 13 17 [[478, 756]] 1.0 6c19 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C1BA P11362 465 765 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.481 13.4939 BLAplus -108.99, 153.45 58.08, 39.21 -83.57, -0.28 58.99, 81.41 -115.03, 23.43 in-in in 7.9616 Saltbr-in 2.7136 HRD-in -69.38, -56.84 85.63, -18.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.26 APE8-rot-na 2.4 APE67-dihe-in -77.29, -7.48 -43.43, -29.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.0 0.222 0.255 A 311.0 265.0 36 30 12 18 [[478, 756]] 1.0 6c1b TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C1BB P11362 463 762 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.3899 13.1727 BLAplus -111.61, 149.0 60.67, 36.26 -77.03, -12.36 51.44, 84.41 -47.03, -51.79 in-in in 7.7468 Saltbr-in 2.7171 HRD-in -68.12, -50.23 87.75, -19.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 84.87 APE8-dihe-out -57.93, -21.43 APE8-rot-na 10.08 APE67-dihe-in -70.65, -8.86 -55.2, -24.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.3082 C488A,C584S None None XRAY 2.0 0.222 0.255 B 311.0 256.0 44 30 13 17 [[478, 756]] 1.0 6c1b TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C1CA P11362 465 765 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.567 13.4933 BLAplus -110.74, 156.89 46.01, 46.87 -92.39, 20.43 55.59, 84.88 -142.57, 39.38 in-in in 8.0726 Saltbr-in 2.7841 HRD-in -74.71, -57.54 87.89, -21.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.9 APE8-rot-na 351.03 APE67-dihe-in -75.96, -1.2 -53.74, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.15 0.228 0.27 A 311.0 276.0 25 30 12 18 [[478, 756]] 1.0 6c1c TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C1CB P11362 463 763 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.2544 13.1457 BLAplus -106.04, 150.67 54.89, 44.71 -87.15, 1.28 50.78, 77.72 -105.41, 5.99 in-in in 7.7196 Saltbr-in 2.6179 HRD-in -67.33, -48.84 84.75, -22.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.16 APE8-dihe-out -62.72, -16.38 APE8-rot-na 19.67 APE67-dihe-in -70.81, -7.72 -62.98, -22.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4111 C488A,C584S None None XRAY 2.15 0.228 0.27 B 311.0 267.0 34 30 14 16 [[478, 756]] 1.0 6c1c TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C1OA P11362 464 765 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.3668 13.4758 BLAplus -110.66, 158.04 49.97, 55.76 -104.93, -8.0 57.72, 84.41 -107.33, 33.26 in-in in 7.7506 Saltbr-in 2.9138 HRD-in -67.38, -50.88 76.07, -0.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.74 APE8-dihe-out -57.13, -28.25 APE8-rot-na 348.02 APE67-dihe-in -72.73, -9.95 -55.13, -30.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.0802 C488A,C584S None None XRAY 2.29 0.239 0.276 A 311.0 280.0 22 30 13 17 [[478, 756]] 1.0 6c1o TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C1OB P11362 464 763 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.2521 13.3533 BLAplus -111.97, 154.41 51.29, 49.54 -91.74, -22.47 56.2, 81.11 -92.83, 58.93 in-in in 7.9163 Saltbr-in 3.1743 HRD-in -68.78, -49.64 75.13, -1.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.32 APE8-rot-na 337.06 APE67-dihe-in -73.03, -7.64 -66.65, -25.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.29 0.239 0.276 B 311.0 262.0 38 30 12 18 [[478, 756]] 1.0 6c1o TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6MZQA P11362 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.0992 13.2584 BLAplus -119.38, 163.65 62.35, 33.69 -91.12, -0.33 55.27, 84.16 -120.86, 13.76 in-in in 7.9486 Saltbr-in 2.6775 HRD-in -73.6, -55.96 80.43, -5.0 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.61 APE8-rot-na 334.89 APE67-dihe-in -72.0, -8.25 -68.04, -26.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 A 311.0 277.0 24 30 12 18 [[478, 756]] 1.0 6mzq TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6MZQB P11362 462 761 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.2291 13.0604 BLAplus -109.43, 157.46 65.55, 34.29 -83.47, -21.73 59.11, 82.16 -85.45, 999.0 in-in in 7.7832 Saltbr-in 2.8499 HRD-in -69.06, -55.52 76.96, -3.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -39.35 APE8-rot-na 334.65 APE67-dihe-in -70.64, -10.51 -51.58, -30.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 B 311.0 260.0 40 30 11 19 [[478, 756]] 1.0 6mzq TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWJA P11362 458 764 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.2638 13.5569 BLAplus -111.1, 165.72 44.3, 59.14 -104.5, -7.94 52.98, 85.2 -108.93, 18.9 in-in in 8.0637 Saltbr-in 3.1247 HRD-in -76.03, -43.68 72.99, -8.16 in-out-out SNCioo out-out ActLoopNT-out 7.9816 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.41, 138.95 APE9-dihe-in -108.01, 100.05 APE8-dihe-out -61.04, -14.23 APE8-rot-na 22.4 APE67-dihe-in -81.18, -2.01 -65.12, -23.42 APE12-dist-na 19.4256 APE11-dist-na 20.4566 APE10-dist-na 17.046 APE9-dist-out 11.3201 C488A,C584S None None XRAY 2.489 0.204 0.25 A 317.0 306.0 1 30 29 1 [[478, 756]] 1.0 4rwj TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWJB P11362 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.3065 13.0754 BLAplus -111.81, 166.65 44.09, 58.11 -104.8, -5.62 52.57, 84.61 -105.75, 19.27 in-in in 7.9338 Saltbr-in 2.8347 HRD-in -75.88, -44.44 70.84, -6.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.6, 139.99 APE9-dihe-in -106.55, 102.92 APE8-dihe-out -58.58, -14.6 APE8-rot-na 336.03 APE67-dihe-in -80.58, -2.45 -66.06, -21.44 APE12-dist-na 999.0 APE11-dist-na 21.7066 APE10-dist-na 18.4779 APE9-dist-out 11.5466 C488A,C584S None None XRAY 2.489 0.204 0.25 B 317.0 282.0 23 30 20 10 [[478, 756]] 1.0 4rwj TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3GQLA P11362 463 774 822.0 GQL:1 Type1.5_Back Inactive DFGin 5.2465 12.9895 BLAplus -123.12, 162.21 54.12, 42.77 -89.74, -13.17 56.15, 71.6 -109.47, 50.5 in-in in 7.9032 Saltbr-in 2.8342 HRD-in -61.52, -47.63 72.57, -4.79 in-out-out SNCioo out-out ActLoopNT-out 8.9245 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -142.49, 22.73 APE9-dihe-out 65.92, 53.77 APE8-dihe-out -55.03, -39.73 APE8-rot-na 329.92 APE67-dihe-in -69.54, -5.25 -36.43, -34.58 APE12-dist-na 16.3214 APE11-dist-na 15.2502 APE10-dist-na 15.9989 APE9-dist-out 11.3151 C488A None None XRAY 2.8 0.252 0.289 A 326.0 287.0 25 30 18 12 [[478, 756]] 1.0 3gql TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3TT0A P11362 461 765 822.0 07J:1 Type1.5_Back Inactive DFGin 5.2541 13.6387 BLAplus -115.26, 155.31 53.22, 40.23 -81.24, -26.95 55.14, 87.79 -91.68, 21.07 in-in in 7.9148 Saltbr-in 3.1056 HRD-in -69.95, -51.8 74.05, -16.9 in-out-out SNCioo out-out ActLoopNT-out 7.6141 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.94, 147.79 APE9-dihe-in -106.75, 107.95 APE8-dihe-out -68.73, -19.6 APE8-rot-na 342.28 APE67-dihe-in -78.56, -18.08 -54.41, -25.03 APE12-dist-na 17.1023 APE11-dist-na 19.4702 APE10-dist-na 16.7308 APE9-dist-out 11.0711 C584S None None XRAY 2.8 0.207 0.261 A 382.0 305.0 0 30 30 0 [[478, 756]] 1.0 3tt0 TYR_FGFR1_HUMAN TYR 3e-104 353.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3TT0B P11362 459 763 822.0 07J:1 Type1.5_Back Inactive DFGin 5.3817 13.3069 BLAplus -116.49, 155.58 53.39, 40.81 -79.81, -25.38 49.88, 91.88 -91.88, 20.46 in-in in 7.8477 Saltbr-in 3.0405 HRD-in -67.66, -50.02 73.72, -9.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 146.21 APE8-rot-na 352.76 APE67-dihe-out -93.95, -12.68 76.26, -23.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.8 0.207 0.261 B 382.0 272.0 33 30 13 17 [[478, 756]] 1.0 3tt0 TYR_FGFR1_HUMAN TYR 3e-104 353.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8Y22A P11362 459 762 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 5.1055 13.1789 BLAplus -113.25, 160.17 59.08, 34.01 -79.21, -14.36 51.54, 87.27 -109.45, 13.99 in-in in 7.9825 Saltbr-in 2.7993 HRD-in -70.73, -44.6 68.63, 0.76 in-out-out SNCioo out-out ActLoopNT-out 9.0288 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.2, 162.84 APE9-dihe-in -99.13, 115.53 APE8-dihe-out -57.19, -22.1 APE8-rot-na 334.84 APE67-dihe-in -76.32, -7.85 -61.99, -21.14 APE12-dist-na 19.6449 APE11-dist-na 20.8827 APE10-dist-na 19.4784 APE9-dist-out 11.673 C584S None None XRAY 2.792 0.197 0.26 A 308.0 288.0 16 30 26 4 [[478, 756]] 1.0 8y22 TYR_FGFR1_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8Y22B P11362 463 765 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 4.9267 13.3865 BLAplus -106.53, 165.87 49.37, 36.23 -76.81, -19.53 50.68, 85.1 -111.75, 14.63 in-in in 8.1525 Saltbr-in 2.7928 HRD-in -74.01, -46.1 72.79, 0.75 in-out-out SNCioo out-out ActLoopNT-out 8.596 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.29, 150.81 APE9-dihe-in -94.3, 115.55 APE8-dihe-out -59.96, -16.81 APE8-rot-na 335.23 APE67-dihe-in -86.59, -1.86 -68.36, -9.3 APE12-dist-na 19.374 APE11-dist-na 20.9185 APE10-dist-na 19.1449 APE9-dist-out 11.7338 C584S None None XRAY 2.792 0.197 0.26 B 308.0 291.0 12 30 30 0 [[478, 756]] 1.0 8y22 TYR_FGFR1_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6NVLA P11362 463 765 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.1279 13.3113 BLAplus -119.52, 157.53 59.31, 34.82 -84.42, -16.16 59.33, 82.45 -101.42, 33.52 in-in in 7.5898 Saltbr-in 2.8655 HRD-in -75.42, -53.52 80.47, -2.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.68, 147.97 APE9-dihe-in -112.42, 91.75 APE8-dihe-out -47.21, -34.96 APE8-rot-na 327.61 APE67-dihe-in -66.06, -15.18 -49.22, -31.67 APE12-dist-na 17.2866 APE11-dist-na 20.5601 APE10-dist-na 17.1824 APE9-dist-out 11.6245 C584S None None XRAY 2.7 0.215 0.263 A 309.0 280.0 23 30 21 9 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6NVLB P11362 461 761 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.2902 13.112 BLAplus -110.71, 154.52 49.9, 58.02 -103.43, -14.13 54.73, 82.29 -99.41, 13.49 in-in in 7.6235 Saltbr-in 3.0252 HRD-in -62.36, -64.19 100.95, -30.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.63 APE8-rot-na 324.79 APE67-dihe-in -73.34, -7.41 -51.06, -32.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 B 309.0 263.0 38 30 12 18 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6NVLC P11362 465 761 822.0 XL6:801 Type1.5_Back Inactive DFGin 5.3955 13.3962 BLAplus -121.16, 162.24 42.87, 55.81 -103.48, -8.54 57.38, 81.17 -97.02, -26.48 in-in in 7.522 Saltbr-in 3.1539 HRD-in -69.09, -49.97 76.47, -2.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -35.16 APE8-rot-na 328.72 APE67-dihe-in -78.06, -0.48 -64.76, -24.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 C 309.0 265.0 32 30 21 9 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6NVLD P11362 471 762 822.0 XL6:804 Type1.5_Back Inactive DFGin 5.1576 13.3104 BLAplus -117.28, 161.88 52.71, 45.04 -93.07, -6.01 60.08, 84.31 -96.46, -42.94 in-none in 7.3629 Saltbr-none 999.0 HRD-in -74.01, -57.04 84.17, -3.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.3, 154.56 APE9-dihe-in -112.92, 85.91 APE8-dihe-out -57.48, -12.84 APE8-rot-na 334.14 APE67-dihe-in -78.36, -8.15 -65.38, -24.93 APE12-dist-na 16.4701 APE11-dist-na 19.4008 APE10-dist-na 16.585 APE9-dist-out 11.3348 C584S None None XRAY 2.7 0.215 0.263 D 309.0 269.0 23 30 21 9 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7WCLA P11362 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.0323 13.5114 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.2337 Saltbr-in 2.9434 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.9796 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.7251 APE11-dist-na 19.0668 APE10-dist-na 16.2264 APE9-dist-out 11.2235 C584S None None XRAY 2.495 0.195 0.23 A 310.0 306.0 0 30 30 0 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 7WCLB P11362 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.6863 13.2974 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.3808 Saltbr-in 2.8041 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.6055 APE10-dist-na 19.4985 APE9-dist-out 11.4021 C584S None None XRAY 2.495 0.195 0.23 B 310.0 285.0 21 30 22 8 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8XLOA P11362 462 764 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.3499 13.4604 BLAplus -120.07, 167.95 56.19, 37.83 -98.04, 4.56 56.68, 90.6 -112.93, 25.35 in-in in 7.9829 Saltbr-in 3.258 HRD-out -75.5, 142.74 -82.57, -37.38 in-out-out SNCioo out-out ActLoopNT-out 7.2004 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.57, 158.46 APE9-dihe-in -97.47, 110.21 APE8-dihe-out -58.39, -18.54 APE8-rot-na 19.21 APE67-dihe-in -81.65, 0.42 -62.39, -18.82 APE12-dist-na 20.741 APE11-dist-na 21.9456 APE10-dist-na 20.2119 APE9-dist-out 11.7779 C584S None None XRAY 2.36 0.21 0.255 A 310.0 293.0 10 30 30 0 [[478, 756]] 1.0 8xlo TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8XLOB P11362 458 763 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.5876 13.1874 BLAplus -122.66, 168.69 59.17, 27.93 -79.17, -12.14 48.47, 88.63 -115.21, 3.75 in-in in 7.7683 Saltbr-in 2.8826 HRD-out -89.09, 129.19 -58.3, -36.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.09, 159.35 APE9-dihe-in -98.63, 108.84 APE8-dihe-out -54.34, -25.08 APE8-rot-na 331.75 APE67-dihe-in -70.85, 2.53 -59.01, -24.97 APE12-dist-na 19.448 APE11-dist-na 20.7383 APE10-dist-na 19.2996 APE9-dist-out 11.7119 C584S None None XRAY 2.36 0.21 0.255 B 310.0 287.0 19 30 24 6 [[478, 756]] 1.0 8xlo TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8XZ7B P11362 461 765 822.0 A1LWW:60804 Type1.5_Back Inactive DFGin 5.2771 13.4856 BLAplus -115.92, 158.14 64.67, 33.78 -87.5, -12.64 58.12, 85.71 -91.55, 13.39 in-in in 8.2684 Saltbr-in 2.9739 HRD-in -72.69, -49.53 74.85, -11.34 in-out-out SNCioo out-out ActLoopNT-out 7.6983 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -73.13, 157.52 APE9-dihe-in -120.81, 83.94 APE8-dihe-out -59.26, -16.83 APE8-rot-na 351.23 APE67-dihe-in -76.52, -7.27 -60.13, -24.1 APE12-dist-na 17.8835 APE11-dist-na 19.5813 APE10-dist-na 16.7541 APE9-dist-out 11.0899 C584S None None XRAY 1.75 0.188 0.225 B 310.0 303.0 2 30 30 0 [[478, 756]] 1.0 8xz7 TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6MZWA P11362 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 4.8216 13.4005 BLAplus -122.44, 164.99 57.07, 40.5 -90.84, 9.02 55.25, 82.2 -134.07, 2.85 in-in in 8.0037 Saltbr-in 2.8192 HRD-in -69.57, -56.52 83.74, -8.47 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.34 APE8-rot-na 329.11 APE67-dihe-in -82.69, 5.42 -51.99, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 A 311.0 282.0 20 30 12 18 [[478, 756]] 1.0 6mzw TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5VNDA P11362 463 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.2281 13.4249 BLAplus -118.27, 161.79 56.96, 41.78 -93.83, -18.18 57.16, 83.64 -76.46, -2.88 in-in in 7.7058 Saltbr-in 3.0109 HRD-in -76.4, -51.16 70.96, 1.97 in-out-out SNCioo out-out ActLoopNT-out 8.3852 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.26, 154.9 APE9-dihe-in -95.33, 115.63 APE8-dihe-out -58.5, -20.28 APE8-rot-na 328.5 APE67-dihe-in -71.98, -7.89 -57.67, -20.31 APE12-dist-na 20.2467 APE11-dist-na 21.3871 APE10-dist-na 19.7461 APE9-dist-out 11.7966 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 A 309.0 302.0 1 30 29 1 [[478, 756]] 1.0 5vnd TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5VNDB P11362 460 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.2864 13.2188 BLAplus -116.66, 159.84 60.5, 40.74 -88.83, -28.65 56.85, 87.63 -76.11, -9.05 in-in in 7.6432 Saltbr-in 3.1348 HRD-in -75.25, -50.66 71.68, -1.94 in-out-out SNCioo out-out ActLoopNT-out 7.9716 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.48, 159.45 APE9-dihe-in -96.83, 113.88 APE8-dihe-out -57.87, -23.88 APE8-rot-na 336.6 APE67-dihe-in -71.96, -8.45 -53.4, -22.22 APE12-dist-na 20.1684 APE11-dist-na 21.3989 APE10-dist-na 19.9278 APE9-dist-out 11.6497 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 B 309.0 295.0 11 30 30 0 [[478, 756]] 1.0 5vnd TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6P68A P11362 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.5681 13.2974 BLAplus -124.18, 155.54 63.3, 48.78 -90.25, -51.15 37.68, 89.45 -72.78, 42.85 in-in in 8.4634 Saltbr-in 3.0682 HRD-in -82.33, -55.3 90.45, -28.65 in-out-out SNCioo out-out ActLoopNT-out 9.2537 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.44, 166.09 APE9-dihe-in -115.93, 115.43 APE8-dihe-out -43.99, -17.59 APE8-rot-na 319.34 APE67-dihe-in -77.38, -22.95 -75.44, -11.63 APE12-dist-na 20.7136 APE11-dist-na 21.7563 APE10-dist-na 19.6548 APE9-dist-out 11.5919 C488A,Y563C None None XRAY 2.9 0.23 0.303 A 309.0 287.0 15 30 27 3 [[478, 756]] 1.0 6p68 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6P68B P11362 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.4999 13.3623 BLAplus -127.31, 162.51 46.96, 56.83 -101.23, -42.4 47.99, 77.97 -84.27, 46.6 in-in in 7.7578 Saltbr-in 3.3016 HRD-in -84.02, -53.61 84.39, -26.28 in-out-out SNCioo out-out ActLoopNT-out 8.8458 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.18, 175.15 APE9-dihe-in -113.49, 131.98 APE8-dihe-out -57.6, -24.27 APE8-rot-na 330.67 APE67-dihe-in -68.05, -15.43 -68.07, -21.93 APE12-dist-na 20.753 APE11-dist-na 22.1816 APE10-dist-na 20.562 APE9-dist-out 11.6663 C488A,Y563C None None XRAY 2.9 0.23 0.303 B 309.0 286.0 16 30 27 3 [[478, 756]] 1.0 6p68 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6P68C P11362 463 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.8214 13.2159 BLAplus -111.29, 171.43 44.74, 37.04 -76.15, -58.04 39.05, 94.26 -70.98, 63.26 in-in in 7.3725 Saltbr-in 2.8855 HRD-in -80.62, -45.97 77.53, -19.73 in-out-out SNCioo out-out ActLoopNT-out 8.2897 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.73, 161.83 APE9-dihe-in -111.63, 125.51 APE8-dihe-out -59.61, -24.78 APE8-rot-na 332.23 APE67-dihe-in -70.27, -21.8 -56.16, -23.37 APE12-dist-na 20.3359 APE11-dist-na 21.4418 APE10-dist-na 19.2263 APE9-dist-out 11.3243 C488A,Y563C None None XRAY 2.9 0.23 0.303 C 309.0 286.0 15 30 27 3 [[478, 756]] 1.0 6p68 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6P69A P11362 462 765 822.0 O21:804 Type1.5_Back Inactive DFGin 5.2934 13.3317 BLAplus -116.62, 153.51 68.44, 36.07 -94.14, -3.31 60.05, 82.99 -102.25, 17.21 in-in in 7.6778 Saltbr-in 2.8285 HRD-in -76.03, -50.91 79.25, -13.3 in-out-out SNCioo out-out ActLoopNT-out 6.9198 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.91, 156.78 APE9-dihe-in -97.6, 112.94 APE8-dihe-out -56.34, -25.16 APE8-rot-na 341.33 APE67-dihe-in -73.31, -6.91 -51.65, -21.86 APE12-dist-na 20.8524 APE11-dist-na 22.1533 APE10-dist-na 20.3724 APE9-dist-out 11.5954 C488A,Y563C None None XRAY 2.2 0.189 0.245 A 309.0 288.0 16 30 30 0 [[478, 756]] 1.0 6p69 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6P69B P11362 461 762 822.0 O21:804 Type1.5_Back Inactive DFGin 5.2379 12.9915 BLAplus -110.73, 150.1 69.98, 35.36 -92.92, -8.35 56.07, 83.61 -81.3, 13.2 in-in in 7.6744 Saltbr-in 2.7228 HRD-in -71.89, -48.99 79.15, -25.42 in-out-out SNCioo out-out ActLoopNT-out 7.4095 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.29, 160.07 APE9-dihe-in -97.38, 114.82 APE8-dihe-out -64.56, -21.47 APE8-rot-na 332.49 APE67-dihe-in -69.85, -7.92 -52.16, -22.61 APE12-dist-na 20.5217 APE11-dist-na 21.6862 APE10-dist-na 19.9636 APE9-dist-out 11.4536 C488A,Y563C None None XRAY 2.2 0.189 0.245 B 309.0 286.0 16 30 30 0 [[478, 756]] 1.0 6p69 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3KXXA P11362 461 765 822.0 No_ligand No_ligand Inactive DFGin 6.8887 14.2587 BLBminus -140.37, -169.46 63.26, 50.32 -78.18, 162.76 296.3, 66.09 151.64, -37.0 in-in in 7.0169 Saltbr-in 2.8305 HRD-out -100.04, 84.29 -55.69, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.55, 44.24 APE9-dihe-in -122.5, 136.32 APE8-dihe-in -50.57, 127.21 APE8-rot-na 327.84 APE67-dihe-in -76.36, 2.91 -67.27, -29.4 APE12-dist-na 14.3372 APE11-dist-na 9.735 APE10-dist-na 7.8605 APE9-dist-in 5.3467 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 A 317.0 305.0 0 30 30 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8JQIB P11362 463 769 822.0 No_ligand No_ligand Inactive DFGin 5.5799 13.7021 BLBplus -110.39, 162.0 66.1, 18.22 -83.81, 164.72 63.85, 90.92 69.71, 13.55 in-in in 8.1475 Saltbr-in 2.879 HRD-in -62.9, -42.83 68.84, -8.19 in-out-in SNCioi out-in ActLoopNT-out 7.7085 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.84, 130.26 APE9-dihe-in -65.71, 153.24 APE8-dihe-in -72.54, 69.48 APE8-rot-na 18.0 APE67-dihe-in -81.24, 0.42 -61.21, -30.47 APE12-dist-na 18.0042 APE11-dist-na 14.2329 APE10-dist-na 16.4083 APE9-dist-in 6.9708 None None None EM 4.1 999.0 999.0 B 822.0 307.0 0 30 30 0 [[478, 756]] 1.0 8jqi TYR_FGFR1_HUMAN TYR 3e-103 351.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8YKIA P11362 464 762 822.0 A1LY1:60801 Type1 Inactive DFGin 5.6779 13.1891 BLBplus -127.03, 161.47 55.43, 32.07 -78.75, 135.31 51.37, 81.9 67.66, 33.8 in-in in 7.9961 Saltbr-in 3.2277 HRD-in -69.63, -52.14 73.54, -1.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.66 APE8-dihe-out -68.91, -19.3 APE8-rot-na 29.84 APE67-dihe-in -67.55, -18.75 -54.73, -36.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.0568 C488A None None XRAY 2.79 0.242 0.288 A 317.0 267.0 32 30 14 16 [[478, 756]] 1.0 8yki TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8YKIB P11362 461 761 822.0 A1LY1:60801 Type1 Inactive DFGin 5.8164 13.0018 BLBplus -127.51, 162.85 54.9, 31.45 -78.58, 134.89 51.65, 81.41 96.69, -107.12 in-in in 7.9675 Saltbr-in 3.2283 HRD-in -70.15, -51.98 73.59, -0.57 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.54 APE8-dihe-out -68.77, -19.51 APE8-rot-na 29.46 APE67-dihe-in -66.31, -19.61 -55.9, -35.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.131 C488A None None XRAY 2.79 0.242 0.288 B 317.0 264.0 37 30 13 17 [[478, 756]] 1.0 8yki TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 3GQLB P11362 463 765 822.0 GQL:1 Type1 Inactive DFGin 5.6088 13.296 BLBplus -128.62, 167.94 48.28, 62.54 -111.2, 147.65 41.12, 83.15 54.74, 40.27 in-in in 8.0883 Saltbr-in 2.95 HRD-in -58.11, -48.09 70.35, -6.25 in-out-none SNCion out-none ActLoopNT-out 8.8534 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.24 APE8-rot-na 35.42 APE67-dihe-in -73.56, 1.23 -76.55, -20.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 B 326.0 276.0 27 30 14 16 [[478, 756]] 1.0 3gql TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 8XZ7A P11362 458 765 822.0 A1LWW:60803 Type1 Inactive DFGin 5.5824 13.0234 BLBplus -119.64, 153.34 65.26, 30.33 -76.98, 170.32 51.66, 84.53 -174.68, 170.61 in-in in 8.2102 Saltbr-in 2.896 HRD-out -86.18, 131.57 -68.41, -19.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.72, 163.01 APE9-dihe-in -98.35, 111.69 APE8-dihe-out -59.15, -22.66 APE8-rot-na 330.38 APE67-dihe-in -69.43, -4.98 -58.15, -24.4 APE12-dist-na 25.2835 APE11-dist-na 26.4421 APE10-dist-na 23.9183 APE9-dist-out 11.3513 C584S None None XRAY 1.75 0.188 0.225 A 310.0 297.0 11 30 26 4 [[478, 756]] 1.0 8xz7 TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5ZV2A P11362 463 762 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.5677 14.1438 BLBplus -131.08, 166.37 55.4, 22.07 -76.03, 127.13 51.59, 83.66 103.79, -116.47 in-in in 7.8578 Saltbr-in 3.1426 HRD-in -69.2, -53.37 81.07, -9.59 in-out-out SNCioo out-out ActLoopNT-out 9.1847 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -156.95, 137.73 APE9-dihe-in -102.4, 101.23 APE8-dihe-out -65.35, -22.62 APE8-rot-na 30.52 APE67-dihe-in -64.41, -13.08 -61.44, -25.69 APE12-dist-na 18.7124 APE11-dist-na 21.0676 APE10-dist-na 17.8389 APE9-dist-out 12.1029 C488A None None XRAY 2.86 0.215 0.269 A 305.0 284.0 16 30 28 2 [[478, 756]] 1.0 5zv2 TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5ZV2B P11362 461 764 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.7346 13.3331 BLBplus -131.99, 168.42 59.16, 17.33 -69.91, 121.62 49.14, 91.18 109.73, -109.09 in-in in 7.949 Saltbr-in 2.8669 HRD-in -69.21, -53.97 80.59, -9.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 120.68 APE9-dihe-in -90.2, 111.18 APE8-dihe-out -62.93, -18.78 APE8-rot-na 29.94 APE67-dihe-in -66.68, -14.01 -56.35, -27.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.9258 APE9-dist-out 11.6098 C488A None None XRAY 2.86 0.215 0.269 B 305.0 281.0 23 30 20 10 [[478, 756]] 1.0 5zv2 TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4NK9A P11362 464 765 822.0 2K5:807 Type1.5_Back Inactive DFGin 5.6428 13.3579 BLBplus -109.95, 156.55 39.62, 77.0 -103.05, 153.56 28.96, 73.43 57.1, 999.0 in-in in 8.098 Saltbr-in 3.3631 HRD-in -55.46, -49.38 77.25, -13.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.12, 153.38 APE9-dihe-in -96.1, 111.38 APE8-dihe-out -57.95, -18.94 APE8-rot-na 334.9 APE67-dihe-in -71.02, -3.8 -60.59, -24.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8934 C488A,C584S None None XRAY 2.57 0.209 0.262 A 309.0 281.0 21 30 23 7 [[478, 756]] 1.0 4nk9 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5B7VB P11362 462 762 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.6766 12.94 BLBplus -116.05, 161.84 53.01, 39.08 -76.06, 133.86 41.64, 92.29 65.64, 39.87 in-in in 7.6165 Saltbr-in 3.029 HRD-in -64.13, -51.82 87.54, -28.51 in-out-out SNCioo out-out ActLoopNT-out 9.4405 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -94.62, 144.39 APE9-dihe-in -82.91, 115.57 APE8-dihe-out -50.0, -27.69 APE8-rot-na 330.02 APE67-dihe-in -70.22, -11.34 -61.05, -21.38 APE12-dist-na 999.0 APE11-dist-na 19.9984 APE10-dist-na 18.2427 APE9-dist-out 11.7021 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 B 310.0 277.0 24 30 24 6 [[478, 756]] 1.0 5b7v TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 5UR1B P11362 464 763 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.2909 13.2475 BLBplus -105.41, 154.97 53.57, 37.31 -77.11, 166.16 58.26, 86.17 69.33, 25.51 in-in in 7.6177 Saltbr-in 2.5963 HRD-in -63.24, -51.37 83.2, -13.32 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -28.36 APE8-rot-na 342.42 APE67-dihe-in -76.21, -4.72 -69.35, -13.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 B 311.0 265.0 35 30 12 18 [[478, 756]] 1.0 5ur1 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4RWLB P11362 458 764 822.0 3ZC:801 Type1.5_Back Inactive DFGin 5.5749 12.8603 BLBplus -118.6, 158.89 63.82, 31.02 -77.01, 152.77 46.13, 88.04 75.46, -144.53 in-in in 7.8641 Saltbr-in 2.7141 HRD-in -76.64, -55.25 80.83, -9.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.43, 164.04 APE9-dihe-in -102.17, 112.77 APE8-dihe-out -51.59, -26.38 APE8-rot-na 327.68 APE67-dihe-in -76.33, -6.25 -60.23, -17.85 APE12-dist-na 20.4616 APE11-dist-na 21.2659 APE10-dist-na 19.7485 APE9-dist-out 11.5255 C488A,C584S None None XRAY 2.193 0.209 0.256 B 317.0 285.0 22 30 24 6 [[478, 756]] 1.0 4rwl TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4F65A P11362 464 765 822.0 0S9:808 Type1 Inactive DFGin 5.6218 13.0799 None -116.38, 166.24 56.16, 50.99 -96.21, 999.0 35.52, 82.62 999.0, 999.0 in-in in 7.9758 Saltbr-in 2.9248 HRD-in -64.44, -52.01 69.63, -13.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.26, 142.02 APE9-dihe-in -87.5, 110.31 APE8-dihe-out -50.81, -23.5 APE8-rot-na 336.61 APE67-dihe-in -69.73, -13.19 -59.55, -23.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.26 0.204 0.235 A 309.0 279.0 23 30 20 10 [[478, 756]] 1.0 4f65 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4NKAB P11362 458 765 822.0 2K7:803 Type1 Inactive DFGin 4.9928 12.588 None -113.09, 172.85 51.3, 36.02 -81.11, 999.0 51.02, 79.07 999.0, 999.0 in-in in 7.7205 Saltbr-in 2.8187 HRD-in -68.57, -53.53 79.69, -21.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -99.94, 158.4 APE9-dihe-in -98.99, 111.75 APE8-dihe-out -53.76, -24.39 APE8-rot-na 331.5 APE67-dihe-in -68.26, -7.43 -55.44, -26.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4239 C488A,C584S None None XRAY 2.19 0.2 0.228 B 309.0 287.0 21 30 24 6 [[478, 756]] 1.0 4nka TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4F65B P11362 460 763 822.0 0S9:808 Type1.5_Back Inactive DFGin 6.1724 11.7443 None -112.37, 28.01 -137.92, 136.63 -123.39, 999.0 315.19, 98.45 999.0, 999.0 in-in in 7.9279 Saltbr-in 2.9079 HRD-in -72.51, -42.53 62.62, -12.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.78, 143.47 APE9-dihe-in -85.99, 110.74 APE8-dihe-out -51.4, -22.91 APE8-rot-na 337.29 APE67-dihe-in -68.78, -13.01 -59.73, -24.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2572 C488A,C584S None None XRAY 2.26 0.204 0.235 B 309.0 279.0 25 30 23 7 [[478, 756]] 1.0 4f65 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6C18B P11362 466 762 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.466 13.1559 None -121.52, 157.51 52.39, 50.92 -96.25, 999.0 51.2, 88.67 999.0, 999.0 in-in in 8.0231 Saltbr-in 2.9239 HRD-in -68.59, -52.77 77.43, -7.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.06 APE8-rot-na 331.63 APE67-dihe-in -71.45, -6.87 -51.83, -28.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 B 311.0 255.0 42 30 10 20 [[478, 756]] 1.0 6c18 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 6MZWB P11362 463 762 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.2433 13.1911 None -113.61, 162.19 59.99, 41.93 -84.77, 999.0 49.28, 82.5 999.0, 999.0 in-in in 7.816 Saltbr-in 2.6843 HRD-in -70.89, -55.55 82.9, -7.56 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-na 29.6 APE67-dihe-in -68.26, -6.41 -48.51, -43.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 B 311.0 258.0 42 30 10 20 [[478, 756]] 1.0 6mzw TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4V04B P11362 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.8725 BBAminus -127.4, -173.98 -164.99, 120.92 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.0147 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.5141 APE11-dist-na 20.9701 APE10-dist-na 19.2978 APE9-dist-out 11.5913 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309.0 289.0 19 30 24 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4V01A P11362 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.6478 9.6834 None -136.22, -176.63 -157.46, 111.62 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.8519 Saltbr-in 2.8239 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.7272 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309.0 273.0 28 30 22 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4V01B P11362 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.4764 9.083 None -140.66, -178.05 -156.06, 123.42 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.9159 Saltbr-in 2.8067 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8136 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309.0 275.0 28 30 22 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 4V04A P11362 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.0506 10.3941 None -127.25, -179.24 -145.47, 116.11 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.8637 Saltbr-in 3.2056 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.6385 APE11-dist-na 21.0205 APE10-dist-na 19.3218 APE9-dist-out 11.7003 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309.0 293.0 10 30 24 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

TYR_FGFR1 (Fibroblast growth factor receptor 1)

Total number of chains: 145
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 114 78.6% 9UHIA
DFGin BLBplus 11 7.6% 8JQIB
DFGin BLAminus 10 6.9% AF-P11362-K1A
DFGin None 5 3.4% 4NKAB
DFGout None 3 2.1% 4V04A
DFGin BLBminus 1 0.7% 3KXXA
DFGout BBAminus 1 0.7% 4V04B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR1 FGFR1_HUMAN 3GQIA P11362 464 770 822.0 ACP:775 ATPlike Active DFGin 6.4659 13.9462 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.7514 Saltbr-in 2.6904 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.9611 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.0832 APE11-dist-na 11.2584 APE10-dist-na 10.1277 APE9-dist-in 7.1373 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326.0 307.0 0 30 30 0 [[478, 756]] 1.0 3gqi Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN AF-P11362-K1A P11362 470 764 822.0 No_ligand No_ligand Active DFGin 6.5854 13.7448 BLAminus -135.24, -172.55 53.83, 70.53 -87.91, 10.86 290.57, 95.64 -59.32, -30.75 in-in in 7.4533 Saltbr-in 2.6485 HRD-in -70.89, -43.2 66.63, -19.06 in-in-in SNCiii in-in ActLoopNT-in 2.9002 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.78, 130.17 APE9-dihe-in -137.78, 151.11 APE8-dihe-in -79.35, 77.49 APE8-rot-na 37.15 APE67-dihe-in -67.5, -12.86 -47.07, -41.3 APE12-dist-na 14.3936 APE11-dist-na 9.9311 APE10-dist-na 9.9898 APE9-dist-in 6.5057 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[478, 756]] 1.0 AF-P11362-K1 Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN AF-P11362-K3A P11362 470 764 822.0 No_ligand No_ligand Active DFGin 6.1465 13.5208 BLAminus -139.78, -177.08 59.37, 66.68 -79.98, 12.43 289.81, 96.12 -59.82, -28.59 in-in in 7.9064 Saltbr-in 2.6591 HRD-in -80.49, -43.82 61.4, -3.43 in-in-in SNCiii in-in ActLoopNT-in 2.9224 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.53, 136.75 APE9-dihe-in -134.21, 129.98 APE8-dihe-in -82.7, 64.06 APE8-rot-na 35.6 APE67-dihe-in -69.03, -12.46 -46.62, -44.88 APE12-dist-na 13.4611 APE11-dist-na 9.7937 APE10-dist-na 8.1551 APE9-dist-in 6.648 None None None AF2 -1.0 1.0 1.0 A 295.0 295.0 0 30 30 0 [[478, 756]] 1.0 AF-P11362-K3 Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3KXXB P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 7.0608 14.5067 BLAminus -138.91, 177.11 64.42, 63.57 -90.83, 31.94 294.07, 81.15 -71.04, -30.05 in-in in 7.2339 Saltbr-in 3.199 HRD-out -89.94, 81.9 -57.82, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.9083 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.01, 74.51 APE9-dihe-in -144.18, 139.02 APE8-dihe-in -51.42, 121.01 APE8-rot-na 327.88 APE67-dihe-in -76.85, -17.4 -68.16, -22.5 APE12-dist-na 14.8931 APE11-dist-na 10.3604 APE10-dist-na 9.1325 APE9-dist-in 5.752 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 B 317.0 305.0 0 30 30 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3KXXC P11362 458 762 822.0 No_ligand No_ligand Inactive DFGin 7.139 13.9922 BLAminus -138.07, -172.42 62.91, 62.15 -92.81, 13.58 296.2, 98.02 -70.01, -16.73 in-in in 7.2426 Saltbr-in 2.6366 HRD-out -88.37, 88.38 -55.25, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.9676 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.88, 68.46 APE9-dihe-in -154.11, 147.86 APE8-dihe-in -47.33, 131.68 APE8-rot-na 28.97 APE67-dihe-in -56.58, -13.9 -82.3, -38.63 APE12-dist-na 15.0864 APE11-dist-na 10.3326 APE10-dist-na 8.9475 APE9-dist-in 6.2614 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 C 317.0 286.0 19 30 30 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3KXXD P11362 458 762 822.0 No_ligand No_ligand Inactive DFGin 6.502 13.6714 BLAminus -133.51, -161.48 51.6, 74.09 -99.67, 22.58 293.84, 93.72 -66.62, -32.71 in-in in 7.5288 Saltbr-in 3.4577 HRD-out -84.43, 73.53 -41.76, -24.93 in-in-in SNCiii in-in ActLoopNT-in 3.1136 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.31, 77.29 APE9-dihe-in -147.89, 135.68 APE8-dihe-in -51.4, 116.54 APE8-rot-na 326.12 APE67-dihe-in -63.39, 3.02 -61.34, -39.64 APE12-dist-na 15.473 APE11-dist-na 10.5609 APE10-dist-na 8.8353 APE9-dist-in 6.2397 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 D 317.0 286.0 19 30 30 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5FLFA P11362 460 762 822.0 No_ligand No_ligand Inactive DFGin 6.5659 13.9215 BLAminus -130.07, -173.3 57.53, 81.51 -106.56, 20.58 287.47, 88.65 -65.69, -26.36 in-in in 7.0608 Saltbr-in 2.6235 HRD-in -77.09, -44.33 71.36, -17.68 in-in-out SNCiio in-out ActLoopNT-in 2.8743 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -122.27, 31.65 APE9-dihe-in -120.82, 141.16 APE8-dihe-in -55.6, 118.0 APE8-rot-na 17.74 APE67-dihe-in -68.76, -3.74 -51.76, -42.09 APE12-dist-na 14.9694 APE11-dist-na 10.4873 APE10-dist-na 8.0447 APE9-dist-in 5.7595 R675G None None XRAY 2.58 0.197 0.255 A 310.0 296.0 7 30 30 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5FLFB P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 6.597 14.2709 BLAminus -131.38, -174.56 57.69, 69.98 -91.26, 21.65 284.1, 89.91 -69.58, -18.15 in-in in 7.2083 Saltbr-in 2.6613 HRD-in -77.24, -42.46 70.08, -13.13 in-in-out SNCiio in-out ActLoopNT-in 2.9501 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.34, 21.86 APE9-dihe-in -108.05, 143.02 APE8-dihe-in -54.9, 122.45 APE8-rot-na 333.47 APE67-dihe-in -66.56, -8.26 -58.19, -40.45 APE12-dist-na 14.7668 APE11-dist-na 10.3425 APE10-dist-na 7.6761 APE9-dist-in 5.5875 R675G None None XRAY 2.58 0.197 0.255 B 310.0 292.0 13 30 30 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5FLFC P11362 464 763 822.0 No_ligand No_ligand Inactive DFGin 6.8788 14.9038 BLAminus -128.63, -179.22 56.68, 76.02 -97.55, 23.96 288.87, 80.23 -64.42, -24.4 in-in in 7.8673 Saltbr-in 2.5932 HRD-in -77.84, -41.46 68.92, -13.37 in-in-out SNCiio in-out ActLoopNT-in 3.0119 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.74, 13.42 APE9-dihe-in -108.0, 146.11 APE8-dihe-in -55.87, 118.95 APE8-rot-na 334.41 APE67-dihe-in -77.03, -3.15 -66.33, -25.17 APE12-dist-na 14.7227 APE11-dist-na 11.0185 APE10-dist-na 8.0397 APE9-dist-in 5.5345 R675G None None XRAY 2.58 0.197 0.255 C 310.0 283.0 17 30 30 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5FLFD P11362 465 763 822.0 No_ligand No_ligand Inactive DFGin 6.5626 14.0755 BLAminus -137.61, -174.47 56.6, 77.52 -99.56, 24.88 289.94, 80.48 -64.3, -28.41 in-in in 7.2769 Saltbr-in 2.8242 HRD-in -82.09, -46.03 69.99, -9.21 in-in-out SNCiio in-out ActLoopNT-in 2.9337 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.36, 26.56 APE9-dihe-in -112.27, 140.35 APE8-dihe-in -53.21, 117.11 APE8-rot-na 330.63 APE67-dihe-in -75.55, -3.28 -53.96, -35.33 APE12-dist-na 14.9431 APE11-dist-na 10.5064 APE10-dist-na 7.9926 APE9-dist-in 5.5979 R675G None None XRAY 2.58 0.197 0.255 D 310.0 290.0 9 30 30 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWIA P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 5.1902 13.2874 BLAplus -105.16, 163.21 56.87, 28.19 -74.61, -16.94 54.32, 87.9 -104.05, 11.37 in-in in 7.9641 Saltbr-in 2.6905 HRD-in -73.3, -52.29 82.32, -10.23 in-out-out SNCioo out-out ActLoopNT-out 8.0996 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.29, 144.76 APE9-dihe-in -100.4, 99.63 APE8-dihe-out -55.34, -23.98 APE8-rot-na 331.55 APE67-dihe-in -74.41, -9.61 -59.83, -21.73 APE12-dist-na 17.4922 APE11-dist-na 19.0334 APE10-dist-na 16.5776 APE9-dist-out 11.2323 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 A 317.0 305.0 0 30 30 0 [[478, 756]] 1.0 4rwi Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWIB P11362 461 763 822.0 No_ligand No_ligand Inactive DFGin 5.1408 13.1536 BLAplus -106.54, 164.69 57.29, 29.78 -77.53, -18.65 57.49, 89.17 -101.92, 7.65 in-in in 7.8788 Saltbr-in 2.8702 HRD-in -73.64, -53.72 81.97, -10.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.37, 146.39 APE9-dihe-in -96.99, 106.58 APE8-dihe-out -51.08, -23.64 APE8-rot-na 329.78 APE67-dihe-in -74.22, -7.08 -61.58, -21.03 APE12-dist-na 999.0 APE11-dist-na 21.6378 APE10-dist-na 19.3161 APE9-dist-out 11.6321 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 B 317.0 280.0 23 30 25 5 [[478, 756]] 1.0 4rwi Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 1FGKA P11362 464 762 822.0 No_ligand No_ligand Inactive DFGin 5.0399 13.1527 BLAplus -117.08, 161.77 60.28, 24.85 -72.88, -22.06 56.54, 82.81 -106.67, 14.32 in-in in 7.8316 Saltbr-in 3.3783 HRD-in -62.23, -53.96 80.79, -13.7 in-out-out SNCioo out-out ActLoopNT-out 8.9817 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.16, 160.27 APE9-dihe-in -100.02, 107.51 APE8-dihe-out -50.6, -26.19 APE8-rot-na 325.57 APE67-dihe-in -72.28, -4.51 -59.98, -18.19 APE12-dist-na 19.5072 APE11-dist-na 20.6663 APE10-dist-na 19.1079 APE9-dist-out 11.7951 None None None XRAY 2.0 0.213 0.261 A 310.0 278.0 21 30 30 0 [[478, 756]] 1.0 1fgk Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 1FGKB P11362 461 761 822.0 No_ligand No_ligand Inactive DFGin 5.1921 12.9337 BLAplus -119.81, 158.37 63.11, 25.45 -77.92, -15.92 57.79, 81.67 -107.61, 13.08 in-in in 7.691 Saltbr-in 3.0319 HRD-in -69.81, -40.78 70.38, -11.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.56, 167.66 APE9-dihe-in -110.12, 112.64 APE8-dihe-out -55.04, -21.46 APE8-rot-na 323.57 APE67-dihe-in -69.19, -4.96 -60.35, -22.4 APE12-dist-na 999.0 APE11-dist-na 20.9639 APE10-dist-na 19.5628 APE9-dist-out 11.5716 C488A None None XRAY 2.0 0.213 0.261 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 1fgk Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4UWYA P11362 462 762 822.0 No_ligand No_ligand Inactive DFGin 5.2911 12.8627 BLAplus -108.05, 160.93 49.5, 43.38 -87.31, -20.81 54.11, 89.18 -97.03, 5.71 in-in in 7.5085 Saltbr-in 2.443 HRD-in -75.4, -42.68 70.46, -5.54 in-out-out SNCioo out-out ActLoopNT-out 7.6585 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.93, 150.1 APE9-dihe-in -108.91, 96.97 APE8-dihe-out -51.49, -30.02 APE8-rot-na 332.53 APE67-dihe-in -69.11, -13.52 -51.63, -33.68 APE12-dist-na 16.7309 APE11-dist-na 19.1922 APE10-dist-na 16.4743 APE9-dist-out 11.016 None None None XRAY 2.305 0.214 0.267 A 310.0 296.0 5 30 30 0 [[478, 756]] 1.0 4uwy Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4UWYB P11362 459 762 822.0 No_ligand No_ligand Inactive DFGin 5.1132 12.7868 BLAplus -107.94, 162.87 51.01, 42.84 -88.14, -19.95 53.77, 88.06 -94.96, 5.78 in-in in 7.4181 Saltbr-in 2.548 HRD-in -75.22, -44.02 71.63, -5.56 in-out-out SNCioo out-out ActLoopNT-out 7.7221 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.53 APE8-dihe-out -53.14, -29.69 APE8-rot-na 332.32 APE67-dihe-in -67.22, -11.8 -51.66, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.7326 None None None XRAY 2.305 0.214 0.267 B 310.0 273.0 31 30 16 14 [[478, 756]] 1.0 4uwy Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3KY2A P11362 458 764 822.0 No_ligand No_ligand Inactive DFGin 5.1417 13.3026 BLAplus -122.69, 172.32 46.54, 42.6 -95.25, -13.81 55.54, 83.43 -110.08, 21.37 in-in in 7.9833 Saltbr-in 2.7043 HRD-in -54.04, -52.31 78.54, -4.33 in-out-out SNCioo out-out ActLoopNT-out 7.9047 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.74, 144.51 APE9-dihe-in -109.2, 106.89 APE8-dihe-out -56.11, -24.62 APE8-rot-na 329.61 APE67-dihe-in -74.45, -13.88 -60.05, -25.51 APE12-dist-na 17.0264 APE11-dist-na 19.6184 APE10-dist-na 16.6111 APE9-dist-out 11.1393 C488A,C584S None None XRAY 2.7 0.206 0.252 A 317.0 305.0 2 30 30 0 [[478, 756]] 1.0 3ky2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3KY2B P11362 460 763 822.0 No_ligand No_ligand Inactive DFGin 5.3065 13.1313 BLAplus -120.14, 165.15 53.12, 37.21 -90.32, -21.71 57.04, 89.19 -96.69, 4.05 in-in in 7.7505 Saltbr-in 2.873 HRD-in -63.32, -45.74 74.66, -3.4 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.35, 149.7 APE9-dihe-in -86.12, 120.09 APE8-dihe-out -58.71, -15.12 APE8-rot-na 326.3 APE67-dihe-in -64.29, -14.63 -68.37, -29.74 APE12-dist-na 19.9297 APE11-dist-na 21.2795 APE10-dist-na 19.8376 APE9-dist-out 11.7932 C488A,C584S None None XRAY 2.7 0.206 0.252 B 317.0 280.0 24 30 24 6 [[478, 756]] 1.0 3ky2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWLA P11362 465 765 822.0 No_ligand No_ligand Inactive DFGin 5.2596 13.1901 BLAplus -120.07, 160.93 64.42, 29.27 -80.33, -20.1 51.65, 89.33 -96.98, 0.13 in-in in 7.7737 Saltbr-in 2.9039 HRD-in -75.31, -52.96 79.05, -10.93 in-out-out SNCioo out-out ActLoopNT-out 8.242 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.23, 163.46 APE9-dihe-in -103.38, 113.99 APE8-dihe-out -51.08, -26.28 APE8-rot-na 327.94 APE67-dihe-in -75.8, -7.21 -59.7, -19.52 APE12-dist-na 19.715 APE11-dist-na 21.1796 APE10-dist-na 19.602 APE9-dist-out 11.6028 C488A,C584S None None XRAY 2.193 0.209 0.256 A 317.0 282.0 19 30 27 3 [[478, 756]] 1.0 4rwl Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5FLFE P11362 466 761 822.0 No_ligand No_ligand Inactive DFGin 5.8568 13.3331 BLAplus -107.08, 156.12 59.3, 89.04 -145.68, 9.21 46.94, 85.34 -107.07, -8.42 in-out in 7.681 Saltbr-out 4.1216 HRD-in -76.44, -47.72 79.39, -32.07 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -134.53, 84.16 APE9-dihe-out 70.54, 76.98 APE8-dihe-out -73.71, -15.89 APE8-rot-na 29.38 APE67-dihe-in -66.59, -10.19 -60.2, -29.73 APE12-dist-na 999.0 APE11-dist-na 15.329 APE10-dist-na 19.6281 APE9-dist-out 11.396 R675G None None XRAY 2.58 0.197 0.255 E 310.0 258.0 38 30 16 14 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5AM7A P11362 458 764 822.0 38O:1000 Type1 Inactive DFGin 5.3219 13.4036 BLAplus -119.96, 160.03 61.93, 31.32 -78.06, -16.68 51.95, 91.0 -102.88, 8.06 in-in in 7.7843 Saltbr-in 2.8211 HRD-in -72.13, -53.65 81.66, -13.87 in-out-out SNCioo out-out ActLoopNT-out 8.8441 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.07, 161.69 APE9-dihe-in -97.7, 110.93 APE8-dihe-out -50.41, -28.65 APE8-rot-na 335.18 APE67-dihe-in -73.88, -5.16 -55.74, -23.35 APE12-dist-na 19.8904 APE11-dist-na 21.1924 APE10-dist-na 19.9341 APE9-dist-out 11.8873 V561M None None XRAY 1.957 0.201 0.254 A 310.0 294.0 13 30 30 0 [[478, 756]] 1.0 5am7 Homo sapiens TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5AM7B P11362 458 762 822.0 38O:1000 Type1 Inactive DFGin 5.351 13.0562 BLAplus -118.51, 161.73 60.87, 31.35 -81.93, -17.68 51.44, 85.63 -98.47, 10.33 in-in in 7.8786 Saltbr-in 3.092 HRD-in -70.81, -53.93 79.14, -12.6 in-out-out SNCioo out-out ActLoopNT-out 8.4934 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.26, 167.43 APE9-dihe-in -92.91, 111.75 APE8-dihe-out -51.15, -27.96 APE8-rot-na 332.74 APE67-dihe-in -72.49, -4.42 -56.51, -22.72 APE12-dist-na 19.2902 APE11-dist-na 21.0595 APE10-dist-na 19.9352 APE9-dist-out 11.7718 V561M None None XRAY 1.957 0.201 0.254 B 310.0 287.0 18 30 25 5 [[478, 756]] 1.0 5am7 Homo sapiens TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWKA P11362 458 764 822.0 66T:60801 Type1 Inactive DFGin 5.334 13.4485 BLAplus -119.61, 171.78 43.5, 42.06 -91.27, -13.97 55.41, 85.99 -97.85, 1.35 in-in in 8.3001 Saltbr-in 2.8581 HRD-in -72.97, -43.98 66.64, 7.94 in-out-out SNCioo out-out ActLoopNT-out 7.6119 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -132.9, 130.16 APE9-dihe-in -81.93, 117.68 APE8-dihe-out -73.74, -2.4 APE8-rot-na 340.19 APE67-dihe-in -78.12, -6.2 -84.98, -15.3 APE12-dist-na 17.0094 APE11-dist-na 18.9505 APE10-dist-na 16.7093 APE9-dist-out 11.0044 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 A 317.0 307.0 0 30 30 0 [[478, 756]] 1.0 4rwk Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4ZSAA P11362 464 765 822.0 4UT:801 Type1 Inactive DFGin 5.2357 13.3584 BLAplus -116.62, 164.17 62.61, 38.9 -97.55, -0.8 57.69, 84.31 -93.9, -12.07 in-in in 7.7271 Saltbr-in 3.0735 HRD-in -75.4, -51.03 78.41, -18.38 in-out-out SNCioo out-out ActLoopNT-out 7.8014 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.19, 166.07 APE9-dihe-in -106.61, 111.7 APE8-dihe-out -53.66, -24.02 APE8-rot-na 328.26 APE67-dihe-in -75.2, -3.02 -58.56, -21.55 APE12-dist-na 20.9966 APE11-dist-na 22.3196 APE10-dist-na 20.7954 APE9-dist-out 11.8029 C488A,C584S None None XRAY 2.0 0.206 0.254 A 308.0 290.0 12 30 30 0 [[478, 756]] 1.0 4zsa Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4ZSAB P11362 462 761 822.0 4UT:801 Type1 Inactive DFGin 5.3779 12.914 BLAplus -118.54, 160.55 64.46, 37.46 -95.07, -9.43 54.72, 89.6 -73.6, -19.27 in-in in 7.6413 Saltbr-in 3.1631 HRD-in -75.52, -45.77 74.73, -25.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.36, 172.16 APE9-dihe-in -104.52, 114.27 APE8-dihe-out -53.39, -26.0 APE8-rot-na 330.81 APE67-dihe-in -73.62, -3.9 -59.13, -21.5 APE12-dist-na 20.7248 APE11-dist-na 22.162 APE10-dist-na 20.8587 APE9-dist-out 11.5249 C488A,C584S None None XRAY 2.0 0.206 0.254 B 308.0 282.0 18 30 24 6 [[478, 756]] 1.0 4zsa Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5Z0SA P11362 464 762 822.0 960:801 Type1 Inactive DFGin 5.1257 13.6012 BLAplus -107.75, 154.51 67.56, 21.06 -67.0, -16.05 58.84, 83.24 -104.7, 10.76 in-in in 8.0938 Saltbr-in 2.7426 HRD-in -68.85, -52.46 79.64, -4.73 in-out-out SNCioo out-out ActLoopNT-out 8.7089 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -91.28, 165.51 APE9-dihe-in -109.21, 113.36 APE8-dihe-out -56.28, -24.44 APE8-rot-na 329.92 APE67-dihe-in -71.21, -1.87 -54.7, -23.75 APE12-dist-na 19.955 APE11-dist-na 21.515 APE10-dist-na 19.768 APE9-dist-out 11.9765 C488A,C584S None None XRAY 2.45 0.227 0.275 A 308.0 285.0 14 30 30 0 [[478, 756]] 1.0 5z0s Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5Z0SB P11362 464 761 822.0 960:801 Type1 Inactive DFGin 5.1968 13.4303 BLAplus -118.1, 161.06 54.97, 27.99 -69.34, -31.76 53.53, 89.4 -87.91, 8.99 in-in in 7.9457 Saltbr-in 2.9791 HRD-in -70.36, -53.32 74.41, -8.98 in-out-out SNCioo out-out ActLoopNT-out 8.8736 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.22, 166.31 APE9-dihe-in -107.5, 114.63 APE8-dihe-out -57.82, -27.73 APE8-rot-na 335.53 APE67-dihe-in -71.06, -7.47 -49.72, -27.2 APE12-dist-na 19.5916 APE11-dist-na 21.3902 APE10-dist-na 19.7826 APE9-dist-out 11.7613 C488A,C584S None None XRAY 2.45 0.227 0.275 B 308.0 281.0 17 30 29 1 [[478, 756]] 1.0 5z0s Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6ITJA P11362 464 765 822.0 AXU:801 Type1 Inactive DFGin 5.0303 13.7907 BLAplus -109.33, 156.39 67.34, 25.69 -70.89, -16.74 55.89, 87.5 -104.45, 10.23 in-in in 8.0335 Saltbr-in 2.7568 HRD-in -71.81, -52.98 81.18, -14.83 in-out-out SNCioo out-out ActLoopNT-out 8.7171 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.06, 160.2 APE9-dihe-in -100.03, 111.11 APE8-dihe-out -53.01, -25.62 APE8-rot-na 330.27 APE67-dihe-in -75.62, -3.59 -58.81, -16.58 APE12-dist-na 19.4597 APE11-dist-na 21.0204 APE10-dist-na 19.4647 APE9-dist-out 11.7727 C488A,C584S None None XRAY 1.994 0.201 0.244 A 308.0 290.0 12 30 30 0 [[478, 756]] 1.0 6itj Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6ITJB P11362 459 761 822.0 AXU:801 Type1 Inactive DFGin 5.2791 13.6611 BLAplus -115.06, 158.21 61.95, 30.4 -73.56, -20.55 53.39, 86.78 -101.45, 8.81 in-in in 7.8577 Saltbr-in 2.7842 HRD-in -74.1, -50.66 79.66, -17.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.82, 164.92 APE9-dihe-in -97.18, 112.3 APE8-dihe-out -56.27, -24.59 APE8-rot-na 332.48 APE67-dihe-in -69.44, -5.6 -58.71, -22.22 APE12-dist-na 19.4677 APE11-dist-na 21.0221 APE10-dist-na 19.8073 APE9-dist-out 11.6524 C488A,C584S None None XRAY 1.994 0.201 0.244 B 308.0 293.0 10 30 25 5 [[478, 756]] 1.0 6itj Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 9CD5A P11362 465 764 822.0 A1AV2:903 Type1 Inactive DFGin 5.1092 13.0413 BLAplus -119.69, 171.16 42.37, 48.64 -93.51, -18.78 55.6, 81.67 -108.27, 19.83 in-in in 7.6418 Saltbr-in 3.4001 HRD-in -70.51, -58.43 92.5, -15.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -123.63, 147.65 APE9-dihe-in -93.38, 113.67 APE8-dihe-out -55.42, -20.8 APE8-rot-na 334.26 APE67-dihe-in -78.47, -7.11 -58.87, -20.29 APE12-dist-na 21.398 APE11-dist-na 21.2383 APE10-dist-na 19.5201 APE9-dist-out 11.6083 C488A,C584S None None XRAY 2.939 0.215 0.263 A 308.0 281.0 19 30 24 6 [[478, 756]] 1.0 9cd5 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 9CD5B P11362 460 764 822.0 A1AV2:902 Type1 Inactive DFGin 5.1115 12.7756 BLAplus -119.68, 169.96 44.78, 47.92 -93.2, -18.16 54.47, 80.79 -103.83, 15.64 in-in in 7.5897 Saltbr-in 3.2422 HRD-in -70.44, -57.93 92.25, -15.3 in-out-out SNCioo out-out ActLoopNT-out 7.9791 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.57, 148.55 APE9-dihe-in -93.36, 113.84 APE8-dihe-out -53.62, -20.73 APE8-rot-na 332.43 APE67-dihe-in -77.99, -7.05 -59.24, -19.94 APE12-dist-na 21.0098 APE11-dist-na 20.993 APE10-dist-na 19.181 APE9-dist-out 11.5839 C488A,C584S None None XRAY 2.939 0.215 0.263 B 308.0 289.0 16 30 28 2 [[478, 756]] 1.0 9cd5 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4F63A P11362 464 762 822.0 0S7:801 Type1 Inactive DFGin 5.2725 13.2273 BLAplus -123.63, 158.75 70.08, 13.43 -68.79, -20.53 59.97, 88.79 -95.8, 8.85 in-in in 7.5241 Saltbr-in 3.2319 HRD-in -74.6, -50.94 76.01, -22.74 in-out-out SNCioo out-out ActLoopNT-out 8.9744 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -83.88, 159.94 APE9-dihe-in -104.27, 121.64 APE8-dihe-out -54.29, -35.97 APE8-rot-na 333.58 APE67-dihe-in -71.9, -7.89 -48.05, -24.06 APE12-dist-na 19.824 APE11-dist-na 21.2942 APE10-dist-na 19.4902 APE9-dist-out 11.8024 C488A,C584S None None XRAY 2.55 0.232 0.287 A 309.0 278.0 21 30 30 0 [[478, 756]] 1.0 4f63 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4F63B P11362 461 761 822.0 0S7:801 Type1 Inactive DFGin 5.1074 12.5898 BLAplus -103.1, 171.09 57.7, 19.47 -72.81, -17.05 60.59, 83.16 -102.04, 8.53 in-none in 7.7314 Saltbr-none 999.0 HRD-in -67.88, -51.25 73.72, -23.66 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.49, 174.14 APE9-dihe-in -102.48, 111.01 APE8-dihe-out -53.24, -29.21 APE8-rot-na 329.82 APE67-dihe-in -68.76, -1.69 -49.63, -27.49 APE12-dist-na 999.0 APE11-dist-na 20.7796 APE10-dist-na 19.7707 APE9-dist-out 11.499 C488A,C584S None None XRAY 2.55 0.232 0.287 B 309.0 271.0 30 30 21 9 [[478, 756]] 1.0 4f63 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4F64A P11362 464 762 822.0 0S8:801 Type1 Inactive DFGin 5.1832 13.1182 BLAplus -126.63, 159.8 67.66, 19.43 -73.38, -15.37 61.14, 82.05 -112.05, 14.31 in-in in 7.8334 Saltbr-in 2.6567 HRD-in -75.01, -53.26 79.37, -13.8 in-out-out SNCioo out-out ActLoopNT-out 8.8889 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.36, 162.32 APE9-dihe-in -110.59, 112.62 APE8-dihe-out -54.21, -21.82 APE8-rot-na 334.94 APE67-dihe-in -73.68, -4.51 -58.01, -22.74 APE12-dist-na 19.9252 APE11-dist-na 21.6236 APE10-dist-na 19.6065 APE9-dist-out 11.7397 C488A,C584S None None XRAY 2.05 0.217 0.269 A 309.0 278.0 21 30 30 0 [[478, 756]] 1.0 4f64 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4F64B P11362 461 761 822.0 0S8:801 Type1 Inactive DFGin 5.1666 12.9047 BLAplus -128.73, 164.19 64.4, 29.6 -84.21, -15.05 59.33, 82.94 -106.3, 1.28 in-in in 7.8942 Saltbr-in 2.8638 HRD-in -73.33, -50.22 71.98, 0.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.2, 170.72 APE9-dihe-in -106.18, 108.15 APE8-dihe-out -52.36, -27.43 APE8-rot-na 328.0 APE67-dihe-in -80.92, -6.4 -55.61, -16.72 APE12-dist-na 999.0 APE11-dist-na 20.9952 APE10-dist-na 19.8534 APE9-dist-out 11.5563 C488A,C584S None None XRAY 2.05 0.217 0.269 B 309.0 272.0 29 30 21 9 [[478, 756]] 1.0 4f64 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4NKAA P11362 464 765 822.0 2K7:805 Type1 Inactive DFGin 5.4599 12.8303 BLAplus -109.75, 172.82 48.9, 35.6 -81.04, -25.72 46.07, 87.87 -114.73, 999.0 in-none in 7.7564 Saltbr-none 999.0 HRD-in -68.09, -53.27 80.47, -22.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.83, 157.85 APE9-dihe-in -101.57, 110.94 APE8-dihe-out -54.92, -24.59 APE8-rot-na 334.91 APE67-dihe-in -67.94, -8.42 -53.61, -27.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.5699 C488A,C584S None None XRAY 2.19 0.2 0.228 A 309.0 279.0 23 30 23 7 [[478, 756]] 1.0 4nka Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4NKSA P11362 465 762 822.0 2M2:801 Type1 Inactive DFGin 5.6302 13.8089 BLAplus -128.87, 161.68 65.74, 29.25 -87.1, -15.4 56.23, 91.24 -92.95, -7.65 in-in in 7.8964 Saltbr-in 3.034 HRD-in -61.09, -57.02 76.92, -17.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.5, 152.38 APE9-dihe-in -96.93, 124.37 APE8-dihe-out -60.38, -26.39 APE8-rot-na 339.01 APE67-dihe-in -76.01, -5.61 -56.44, -21.34 APE12-dist-na 20.0116 APE11-dist-na 21.7204 APE10-dist-na 19.6876 APE9-dist-out 11.7093 C488A,C584S None None XRAY 2.5 0.223 0.278 A 309.0 265.0 33 30 24 6 [[478, 756]] 1.0 4nks Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4NKSB P11362 461 761 822.0 2M2:801 Type1 Inactive DFGin 5.4695 13.0819 BLAplus -121.26, 176.2 65.04, 19.79 -85.17, -9.87 56.43, 80.08 -103.8, -4.05 in-in in 7.8089 Saltbr-in 3.2276 HRD-in -66.41, -53.36 81.34, -22.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.88, 166.85 APE9-dihe-in -99.02, 113.91 APE8-dihe-out -58.98, -23.63 APE8-rot-na 332.76 APE67-dihe-in -64.8, 1.58 -54.87, -32.1 APE12-dist-na 999.0 APE11-dist-na 20.7252 APE10-dist-na 19.5363 APE9-dist-out 11.7273 C488A,C584S None None XRAY 2.5 0.223 0.278 B 309.0 271.0 30 30 21 9 [[478, 756]] 1.0 4nks Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4UWBA P11362 464 765 822.0 JVT:1769 Type1 Inactive DFGin 5.3164 13.2986 BLAplus -113.09, 161.83 71.69, 23.97 -88.05, -18.23 56.26, 82.28 -95.96, 11.67 in-in in 7.8734 Saltbr-in 2.7255 HRD-in -67.29, -55.31 79.69, -18.23 in-out-out SNCioo out-out ActLoopNT-out 8.9608 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 154.4 APE9-dihe-in -93.53, 118.15 APE8-dihe-out -56.85, -29.21 APE8-rot-na 332.74 APE67-dihe-in -81.26, -7.02 -49.23, -21.08 APE12-dist-na 19.6917 APE11-dist-na 21.3819 APE10-dist-na 19.6057 APE9-dist-out 11.7811 C488A,C584S None None XRAY 2.31 0.231 0.272 A 309.0 299.0 3 30 29 1 [[478, 756]] 1.0 4uwb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4UWBB P11362 459 765 822.0 JVT:1768 Type1 Inactive DFGin 5.4368 13.0303 BLAplus -114.82, 162.53 65.13, 21.85 -74.05, -17.91 55.13, 90.89 -100.48, 4.93 in-in in 7.8876 Saltbr-in 2.7084 HRD-in -76.21, -52.64 84.1, -25.36 in-out-out SNCioo out-out ActLoopNT-out 7.9333 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.09, 162.16 APE9-dihe-in -103.08, 113.2 APE8-dihe-out -55.06, -17.49 APE8-rot-na 323.82 APE67-dihe-in -71.23, -5.74 -60.29, -25.5 APE12-dist-na 20.0048 APE11-dist-na 21.3879 APE10-dist-na 19.8969 APE9-dist-out 11.5965 C488A,C584S None None XRAY 2.31 0.231 0.272 B 309.0 299.0 8 30 27 3 [[478, 756]] 1.0 4uwb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4UWCA P11362 465 765 822.0 4Y0:1773 Type1 Inactive DFGin 5.1849 13.2183 BLAplus -114.28, 167.51 64.08, 17.08 -73.37, -20.76 56.56, 86.09 -95.43, 0.2 in-in in 7.6658 Saltbr-in 2.7686 HRD-in -68.21, -55.41 81.81, -19.33 in-out-out SNCioo out-out ActLoopNT-out 8.0095 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.15, 154.48 APE9-dihe-in -99.31, 111.29 APE8-dihe-out -53.23, -22.86 APE8-rot-na 338.31 APE67-dihe-in -68.82, -8.72 -56.37, -24.16 APE12-dist-na 20.301 APE11-dist-na 21.1983 APE10-dist-na 19.3787 APE9-dist-out 11.7572 C488A,C584S None None XRAY 1.96 0.179 0.206 A 309.0 301.0 0 30 30 0 [[478, 756]] 1.0 4uwc Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4UWCB P11362 459 764 822.0 4Y0:1770 Type1 Inactive DFGin 5.2203 13.0219 BLAplus -114.0, 163.28 67.1, 18.57 -73.54, -21.45 56.42, 85.19 -95.52, -0.76 in-in in 7.5903 Saltbr-in 2.9197 HRD-in -68.93, -54.08 82.79, -14.74 in-out-out SNCioo out-out ActLoopNT-out 8.3432 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.38, 156.7 APE9-dihe-in -100.76, 111.03 APE8-dihe-out -54.68, -24.33 APE8-rot-na 334.31 APE67-dihe-in -64.61, -11.0 -54.66, -28.32 APE12-dist-na 20.0881 APE11-dist-na 21.1466 APE10-dist-na 19.4809 APE9-dist-out 11.7331 C488A,C584S None None XRAY 1.96 0.179 0.206 B 309.0 301.0 5 30 30 0 [[478, 756]] 1.0 4uwc Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5O49A P11362 464 764 822.0 9K5:801 Type1 Inactive DFGin 5.2397 13.6382 BLAplus -124.98, 161.58 68.85, 20.17 -74.75, -11.05 61.69, 77.84 -110.93, 4.69 in-out in 8.1254 Saltbr-out 5.5459 HRD-in -64.73, -48.02 76.28, -6.18 out-out-out SNCooo out-out ActLoopNT-out 8.7824 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.25, 168.76 APE9-dihe-in -119.19, 119.01 APE8-dihe-out -64.8, -20.97 APE8-rot-na 343.93 APE67-dihe-in -73.72, -10.74 -55.47, -23.05 APE12-dist-na 19.5652 APE11-dist-na 21.14 APE10-dist-na 19.4995 APE9-dist-out 11.833 C488A,C584S None None XRAY 1.91 0.2 0.22 A 309.0 289.0 12 30 30 0 [[478, 756]] 1.0 5o49 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5O49B P11362 460 765 822.0 9K5:801 Type1 Inactive DFGin 5.6188 12.9288 BLAplus -126.58, 172.58 67.38, 24.13 -84.06, -18.33 50.82, 87.05 -104.51, 13.86 in-out in 7.6377 Saltbr-out 4.5004 HRD-in -61.81, -47.66 75.62, -5.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.43, 163.49 APE9-dihe-in -105.31, 114.78 APE8-dihe-out -56.47, -25.97 APE8-rot-na 333.8 APE67-dihe-in -70.86, -8.05 -56.14, -23.8 APE12-dist-na 19.0124 APE11-dist-na 20.4124 APE10-dist-na 18.7866 APE9-dist-out 11.7226 C488A,C584S None None XRAY 1.91 0.2 0.22 B 309.0 286.0 20 30 25 5 [[478, 756]] 1.0 5o49 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5O4AA P11362 464 764 822.0 9K8:804 Type1 Inactive DFGin 5.4116 13.5446 BLAplus -122.09, 166.75 52.86, 39.44 -89.66, -24.51 52.16, 85.77 -93.11, 3.02 in-out in 7.9213 Saltbr-out 5.7074 HRD-in -69.28, -47.39 73.72, -11.63 out-out-out SNCooo out-out ActLoopNT-out 8.755 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.02, 156.72 APE9-dihe-in -102.28, 120.59 APE8-dihe-out -56.89, -30.5 APE8-rot-na 333.66 APE67-dihe-in -72.75, -8.94 -55.59, -20.78 APE12-dist-na 20.0842 APE11-dist-na 21.4594 APE10-dist-na 19.6526 APE9-dist-out 11.8991 None None None XRAY 2.01 0.217 0.225 A 309.0 290.0 11 30 30 0 [[478, 756]] 1.0 5o4a Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5O4AB P11362 460 763 822.0 9K8:802 Type1 Inactive DFGin 5.5206 13.0943 BLAplus -119.73, 164.81 56.03, 47.68 -94.68, -27.26 47.68, 87.08 -89.69, 6.98 in-out in 7.7343 Saltbr-out 4.1087 HRD-in -64.38, -47.45 77.25, -12.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.24, 154.27 APE9-dihe-in -101.59, 121.81 APE8-dihe-out -57.48, -31.39 APE8-rot-na 330.82 APE67-dihe-in -66.62, 0.37 -53.02, -29.01 APE12-dist-na 20.0179 APE11-dist-na 21.0494 APE10-dist-na 19.1025 APE9-dist-out 11.7028 None None None XRAY 2.01 0.217 0.225 B 309.0 291.0 13 30 25 5 [[478, 756]] 1.0 5o4a Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7OZBAAA P11362 464 765 822.0 47I:801 Type1 Inactive DFGin 5.1652 13.2255 BLAplus -113.5, 164.02 64.24, 28.44 -81.1, -17.3 55.31, 86.35 -99.81, -4.02 in-in in 7.6783 Saltbr-in 3.0354 HRD-in -68.22, -55.33 81.75, -15.47 in-out-out SNCioo out-out ActLoopNT-out 8.6293 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.53, 159.74 APE9-dihe-in -101.43, 112.26 APE8-dihe-out -54.35, -25.93 APE8-rot-na 332.55 APE67-dihe-in -70.65, -7.52 -55.15, -25.11 APE12-dist-na 19.2916 APE11-dist-na 20.7453 APE10-dist-na 19.1948 APE9-dist-out 11.6637 C488A,C584S None None XRAY 1.71 0.211 0.244 AAA 309.0 288.0 14 30 30 0 [[478, 756]] 1.0 7ozb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7OZBBBB P11362 460 764 822.0 47I:801 Type1 Inactive DFGin 5.2201 12.8529 BLAplus -116.55, 158.6 67.07, 25.64 -79.35, -20.91 57.12, 84.44 -89.98, -6.37 in-in in 7.6315 Saltbr-in 2.9829 HRD-in -68.5, -59.33 86.86, -18.0 in-out-out SNCioo out-out ActLoopNT-out 8.1932 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.69, 159.38 APE9-dihe-in -99.92, 110.92 APE8-dihe-out -56.91, -22.49 APE8-rot-na 333.27 APE67-dihe-in -69.35, -9.22 -56.3, -24.07 APE12-dist-na 19.5566 APE11-dist-na 20.9014 APE10-dist-na 19.3195 APE9-dist-out 11.5573 C488A,C584S None None XRAY 1.71 0.211 0.244 BBB 309.0 291.0 14 30 30 0 [[478, 756]] 1.0 7ozb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7OZDAAA P11362 464 765 822.0 42I:801 Type1 Inactive DFGin 5.1891 13.3222 BLAplus -116.42, 163.08 62.72, 27.25 -80.95, -15.5 58.36, 83.15 -93.3, -6.95 in-in in 7.6994 Saltbr-in 2.8847 HRD-in -70.31, -57.17 82.73, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.1, 157.43 APE9-dihe-in -99.3, 111.88 APE8-dihe-out -57.0, -23.76 APE8-rot-na 335.77 APE67-dihe-in -73.24, -6.2 -56.45, -22.92 APE12-dist-na 20.0675 APE11-dist-na 21.4554 APE10-dist-na 19.818 APE9-dist-out 11.756 C488A,C584S None None XRAY 1.82 0.201 0.241 AAA 309.0 282.0 20 30 24 6 [[478, 756]] 1.0 7ozd Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7OZDBBB P11362 460 763 822.0 42I:801 Type1 Inactive DFGin 5.2176 12.8672 BLAplus -120.15, 162.48 66.77, 26.73 -83.0, -17.85 57.88, 82.23 -92.89, -7.69 in-in in 7.5473 Saltbr-in 2.9696 HRD-in -73.06, -57.3 87.17, -16.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -111.05, 157.78 APE9-dihe-in -98.55, 112.28 APE8-dihe-out -56.64, -24.18 APE8-rot-na 331.82 APE67-dihe-in -72.02, -11.22 -53.55, -23.65 APE12-dist-na 19.616 APE11-dist-na 20.9379 APE10-dist-na 19.3656 APE9-dist-out 11.5993 C488A,C584S None None XRAY 1.82 0.201 0.241 BBB 309.0 285.0 19 30 25 5 [[478, 756]] 1.0 7ozd Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7OZFAAA P11362 465 765 822.0 466:801 Type1 Inactive DFGin 5.2955 13.468 BLAplus -117.68, 161.62 66.46, 36.41 -95.38, -7.29 57.95, 82.09 -95.91, -11.26 in-in in 7.8017 Saltbr-in 3.0344 HRD-in -74.16, -54.6 82.1, -14.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 162.73 APE9-dihe-in -101.57, 112.99 APE8-dihe-out -53.92, -25.84 APE8-rot-na 335.55 APE67-dihe-in -73.42, -8.15 -56.91, -22.71 APE12-dist-na 20.3344 APE11-dist-na 21.6782 APE10-dist-na 20.2 APE9-dist-out 11.7273 None None None XRAY 1.82 0.206 0.242 AAA 309.0 288.0 13 30 25 5 [[478, 756]] 1.0 7ozf Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7OZFBBB P11362 460 763 822.0 466:801 Type1 Inactive DFGin 5.2534 13.0233 BLAplus -116.0, 158.26 69.37, 33.48 -90.88, -17.29 57.42, 83.97 -77.99, -12.47 in-in in 7.6429 Saltbr-in 2.9656 HRD-in -73.91, -57.88 84.04, -15.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.71, 160.57 APE9-dihe-in -98.6, 110.79 APE8-dihe-out -55.8, -24.65 APE8-rot-na 332.84 APE67-dihe-in -74.09, -8.17 -55.72, -20.54 APE12-dist-na 20.458 APE11-dist-na 21.8593 APE10-dist-na 20.1777 APE9-dist-out 11.6515 None None None XRAY 1.82 0.206 0.242 BBB 309.0 282.0 22 30 25 5 [[478, 756]] 1.0 7ozf Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 1AGWA P11362 464 762 822.0 SU2:1001 Type1 Inactive DFGin 5.274 13.3892 BLAplus -121.22, 164.09 62.54, 22.82 -75.41, -18.74 57.89, 80.74 -105.07, 9.46 in-out in 7.7097 Saltbr-out 3.8446 HRD-in -69.09, -52.68 78.93, -10.47 out-out-out SNCooo out-out ActLoopNT-out 9.0718 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.44, 164.07 APE9-dihe-in -103.49, 105.01 APE8-dihe-out -48.23, -28.22 APE8-rot-na 326.86 APE67-dihe-in -79.1, -0.7 -60.74, -14.06 APE12-dist-na 19.7105 APE11-dist-na 20.8726 APE10-dist-na 19.2569 APE9-dist-out 11.9035 None None None XRAY 2.4 0.194 0.28 A 310.0 278.0 21 30 30 0 [[478, 756]] 1.0 1agw Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 1AGWB P11362 461 761 822.0 SU2:1000 Type1 Inactive DFGin 5.1047 12.9272 BLAplus -118.48, 160.09 61.53, 23.36 -75.62, -9.51 55.77, 89.71 -113.95, 12.53 in-in in 7.7742 Saltbr-in 2.9735 HRD-in -65.85, -35.14 62.11, -1.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.88, 159.91 APE9-dihe-in -102.85, 114.8 APE8-dihe-out -54.83, -28.49 APE8-rot-na 327.14 APE67-dihe-in -71.12, -9.61 -53.83, -20.83 APE12-dist-na 999.0 APE11-dist-na 21.087 APE10-dist-na 19.5591 APE9-dist-out 11.7943 C488A None None XRAY 2.4 0.194 0.28 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 1agw Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 1FGIA P11362 464 762 822.0 SU1:1001 Type1 Inactive DFGin 5.2448 13.0507 BLAplus -118.43, 166.43 66.52, 8.73 -64.13, -34.61 60.57, 85.04 -94.1, 14.31 in-out in 7.8098 Saltbr-out 4.3938 HRD-in -65.25, -56.3 86.33, -6.46 out-out-out SNCooo out-out ActLoopNT-out 9.0188 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.01, 168.11 APE9-dihe-in -109.23, 108.22 APE8-dihe-out -49.03, -28.53 APE8-rot-na 326.13 APE67-dihe-in -78.81, -8.46 -60.3, -12.78 APE12-dist-na 19.4008 APE11-dist-na 20.9219 APE10-dist-na 19.2133 APE9-dist-out 11.7398 C488A None None XRAY 2.5 0.19 0.27 A 310.0 283.0 16 30 30 0 [[478, 756]] 1.0 1fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 1FGIB P11362 461 761 822.0 SU1:1000 Type1 Inactive DFGin 5.0855 12.8872 BLAplus -129.12, 161.76 68.96, 4.34 -61.61, -28.72 62.68, 83.75 -98.14, 18.47 in-in in 7.9774 Saltbr-in 3.237 HRD-in -67.23, -42.86 65.67, 6.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.03, 163.6 APE9-dihe-in -107.58, 116.43 APE8-dihe-out -54.66, -25.86 APE8-rot-na 323.83 APE67-dihe-in -66.67, -9.45 -56.63, -25.45 APE12-dist-na 999.0 APE11-dist-na 21.117 APE10-dist-na 19.5572 APE9-dist-out 11.7854 C488A None None XRAY 2.5 0.19 0.27 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 1fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5AM6A P11362 458 765 822.0 38O:61766 Type1 Inactive DFGin 5.201 13.2703 BLAplus -112.58, 159.52 61.38, 32.49 -78.96, -18.15 54.05, 84.03 -102.14, 12.3 in-in in 7.7152 Saltbr-in 3.2516 HRD-in -73.83, -55.77 84.43, -16.37 in-out-out SNCioo out-out ActLoopNT-out 8.7281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.68, 158.35 APE9-dihe-in -101.09, 116.06 APE8-dihe-out -55.18, -24.78 APE8-rot-na 339.12 APE67-dihe-in -70.49, -7.18 -57.16, -24.6 APE12-dist-na 19.7602 APE11-dist-na 21.181 APE10-dist-na 19.8607 APE9-dist-out 11.7652 None None None XRAY 1.96 0.216 0.252 A 310.0 294.0 14 30 30 0 [[478, 756]] 1.0 5am6 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5AM6B P11362 458 762 822.0 38O:61763 Type1 Inactive DFGin 5.2795 13.0402 BLAplus -109.26, 159.81 58.35, 42.16 -91.18, -11.81 51.78, 82.49 -107.62, 15.27 in-in in 7.6454 Saltbr-in 3.4946 HRD-in -73.63, -54.03 80.88, -21.94 in-out-out SNCioo out-out ActLoopNT-out 8.6147 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.73, 157.38 APE9-dihe-in -92.88, 109.99 APE8-dihe-out -51.36, -29.92 APE8-rot-na 334.27 APE67-dihe-in -70.82, -6.38 -56.34, -19.57 APE12-dist-na 999.0 APE11-dist-na 21.1311 APE10-dist-na 19.7444 APE9-dist-out 11.6365 None None None XRAY 1.96 0.216 0.252 B 310.0 280.0 25 30 17 13 [[478, 756]] 1.0 5am6 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5UQ0A P11362 464 765 822.0 WP1:801 Type1 Inactive DFGin 5.2233 13.3452 BLAplus -129.51, 154.04 71.7, 22.04 -75.61, 2.54 58.4, 85.52 -125.18, 1.34 in-none in 7.8436 Saltbr-none 999.0 HRD-in -67.62, -52.6 81.66, -15.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 93.59 APE8-dihe-out -63.72, -18.01 APE8-rot-na 26.7 APE67-dihe-in -66.9, -7.24 -49.77, -36.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2474 C488A,C584S None None XRAY 2.3 0.237 0.294 A 311.0 266.0 36 30 13 17 [[478, 756]] 1.0 5uq0 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5UQ0B P11362 463 762 822.0 WP1:801 Type1 Inactive DFGin 5.252 13.1182 BLAplus -135.89, 161.84 57.67, 28.98 -76.93, -27.79 58.9, 86.78 -79.34, -7.22 in-in in 8.18 Saltbr-in 2.6375 HRD-in -67.2, -48.58 76.55, -0.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -106.5 APE8-dihe-out -49.01, -32.28 APE8-rot-na 23.14 APE67-dihe-in -80.37, 4.41 -44.32, -39.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.0692 C488A,C584S None None XRAY 2.3 0.237 0.294 B 311.0 256.0 44 30 13 17 [[478, 756]] 1.0 5uq0 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3JS2A P11362 464 765 822.0 VM1:801 Type1 Inactive DFGin 5.153 13.3035 BLAplus -121.66, 167.26 60.21, 27.33 -82.6, -17.8 54.2, 84.02 -103.88, 10.59 in-in in 7.7242 Saltbr-in 3.0512 HRD-in -72.72, -56.56 85.97, -17.24 in-out-out SNCioo out-out ActLoopNT-out 7.9689 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.37, 154.98 APE9-dihe-in -92.36, 117.27 APE8-dihe-out -54.75, -26.7 APE8-rot-na 329.63 APE67-dihe-in -71.32, -6.64 -59.57, -19.47 APE12-dist-na 19.1598 APE11-dist-na 20.7834 APE10-dist-na 19.3186 APE9-dist-out 11.8143 C488A,C584S None None XRAY 2.2 0.216 0.259 A 317.0 295.0 7 30 30 0 [[478, 756]] 1.0 3js2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3JS2B P11362 459 762 822.0 VM1:801 Type1 Inactive DFGin 5.166 12.9148 BLAplus -117.79, 168.89 57.38, 26.57 -81.81, -21.58 58.31, 81.41 -101.15, 4.46 in-in in 7.4152 Saltbr-in 2.8977 HRD-in -70.61, -55.45 85.21, -19.22 in-out-out SNCioo out-out ActLoopNT-out 8.3884 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.77, 164.88 APE9-dihe-in -101.88, 109.77 APE8-dihe-out -47.5, -33.8 APE8-rot-na 323.58 APE67-dihe-in -71.37, -10.85 -58.97, -16.94 APE12-dist-na 19.4281 APE11-dist-na 20.9341 APE10-dist-na 19.561 APE9-dist-out 11.7757 C488A,C584S None None XRAY 2.2 0.216 0.259 B 317.0 291.0 13 30 30 0 [[478, 756]] 1.0 3js2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3GQLC P11362 463 766 822.0 GQL:1 Type1 Inactive DFGin 5.708 13.0273 BLAplus -123.78, 172.03 54.97, 32.17 -87.82, -13.88 53.39, 70.63 -108.09, 38.81 in-in in 7.8051 Saltbr-in 2.6157 HRD-in -59.51, -40.97 72.56, -22.95 in-out-none SNCion out-none ActLoopNT-out 8.7583 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.55 APE8-rot-na 32.95 APE67-dihe-in -61.65, -18.42 -80.52, -27.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 C 326.0 275.0 29 30 14 16 [[478, 756]] 1.0 3gql Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8JMZA P11362 460 765 822.0 UKI:60801 Type1 Inactive DFGin 5.1589 13.2886 BLAplus -113.58, 162.96 62.0, 28.58 -83.36, -13.84 56.58, 89.17 -102.65, 12.75 in-in in 7.8587 Saltbr-in 2.8351 HRD-in -72.3, -51.47 78.17, -4.24 in-out-out SNCioo out-out ActLoopNT-out 7.9805 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.22, 148.56 APE9-dihe-in -107.32, 99.52 APE8-dihe-out -56.46, -18.86 APE8-rot-na 328.17 APE67-dihe-in -74.96, -9.03 -56.04, -27.86 APE12-dist-na 16.4248 APE11-dist-na 18.9969 APE10-dist-na 16.2227 APE9-dist-out 11.0211 C584S None None XRAY 1.988 0.166 0.205 A 310.0 306.0 0 30 30 0 [[478, 756]] 1.0 8jmz Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8JMZB P11362 458 763 822.0 UKI:60801 Type1 Inactive DFGin 5.259 13.0071 BLAplus -114.88, 158.62 61.68, 33.22 -84.25, -18.02 53.38, 88.43 -92.93, -0.34 in-in in 7.7668 Saltbr-in 2.9243 HRD-in -72.45, -50.78 74.31, -4.23 in-out-out SNCioo out-out ActLoopNT-out 8.3535 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.73, 168.34 APE9-dihe-in -103.17, 113.28 APE8-dihe-out -51.14, -25.22 APE8-rot-na 328.21 APE67-dihe-in -74.28, -2.47 -57.8, -24.89 APE12-dist-na 20.439 APE11-dist-na 21.4008 APE10-dist-na 20.0649 APE9-dist-out 11.5011 C584S None None XRAY 1.988 0.166 0.205 B 310.0 290.0 16 30 27 3 [[478, 756]] 1.0 8jmz Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 9UHCA P11362 458 764 822.0 A1EPE:60801 Type1 Inactive DFGin 5.0891 13.5661 BLAplus -99.26, 163.63 67.92, 18.69 -73.13, -23.6 54.69, 89.65 -94.23, 7.24 in-in in 8.5804 Saltbr-in 2.8372 HRD-in -81.76, -52.28 81.48, -12.21 in-out-out SNCioo out-out ActLoopNT-out 7.6895 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.01, 148.62 APE9-dihe-in -107.23, 98.65 APE8-dihe-out -61.69, -18.58 APE8-rot-na 332.39 APE67-dihe-in -73.38, -10.07 -53.51, -28.36 APE12-dist-na 17.3301 APE11-dist-na 19.8276 APE10-dist-na 16.8879 APE9-dist-out 11.0839 None None None XRAY 1.88 0.173 0.205 A 310.0 307.0 0 30 30 0 [[478, 756]] 1.0 9uhc Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 9UHCB P11362 458 763 822.0 A1EPE:60801 Type1 Inactive DFGin 5.2803 12.9098 BLAplus -104.01, 159.23 73.73, 21.61 -75.73, -25.49 53.38, 87.57 -92.18, 7.01 in-in in 7.958 Saltbr-in 3.2635 HRD-in -83.66, -52.1 79.1, -13.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.36, 141.0 APE9-dihe-in -101.25, 92.23 APE8-dihe-out -59.77, -24.69 APE8-rot-na 330.6 APE67-dihe-in -77.73, -0.07 -57.66, -24.92 APE12-dist-na 17.3904 APE11-dist-na 20.1263 APE10-dist-na 17.1087 APE9-dist-out 11.2956 None None None XRAY 1.88 0.173 0.205 B 310.0 286.0 20 30 23 7 [[478, 756]] 1.0 9uhc Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 9UHIA P11362 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.4362 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.2512 Saltbr-in 2.8878 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.5114 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.6718 APE10-dist-na 16.6848 APE9-dist-out 11.0826 None None None XRAY 1.76 0.163 0.197 A 310.0 307.0 0 30 30 0 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 9UHIB P11362 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.2132 12.7377 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.7681 Saltbr-in 3.4492 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.3515 APE11-dist-na 20.6822 APE10-dist-na 16.9654 APE9-dist-out 11.3637 None None None XRAY 1.76 0.163 0.197 B 310.0 286.0 20 30 23 7 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5A46A P11362 464 766 822.0 38O:1769 Type1 Inactive DFGin 5.2132 13.149 BLAplus -118.77, 162.9 58.04, 28.78 -73.18, -26.4 58.45, 90.15 -96.03, 5.5 in-in in 7.5128 Saltbr-in 3.005 HRD-in -57.82, -48.72 70.95, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.0, 143.36 APE9-dihe-in -88.58, 110.07 APE8-dihe-out -58.5, -16.77 APE8-rot-na 337.71 APE67-dihe-in -76.67, -10.73 -63.67, -15.99 APE12-dist-na 20.0328 APE11-dist-na 21.3237 APE10-dist-na 19.4318 APE9-dist-out 12.0888 None None None XRAY 2.63 0.182 0.246 A 386.0 290.0 13 30 27 3 [[478, 756]] 1.0 5a46 Homo sapiens TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5A46B P11362 458 766 822.0 38O:1767 Type1 Inactive DFGin 5.33 12.787 BLAplus -120.14, 161.93 66.72, 19.6 -75.13, -22.14 56.34, 83.44 -97.38, -0.25 in-in in 7.5925 Saltbr-in 2.7985 HRD-in -68.23, -43.1 73.28, -14.2 in-out-out SNCioo out-out ActLoopNT-out 7.9798 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -119.49, 150.14 APE9-dihe-in -90.22, 111.65 APE8-dihe-out -53.72, -24.65 APE8-rot-na 331.17 APE67-dihe-in -66.01, -7.4 -51.07, -30.75 APE12-dist-na 20.2916 APE11-dist-na 21.2715 APE10-dist-na 19.9075 APE9-dist-out 11.8789 None None None XRAY 2.63 0.182 0.246 B 386.0 298.0 11 30 30 0 [[478, 756]] 1.0 5a46 Homo sapiens TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWKB P11362 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.7367 13.232 BLAplus -119.15, 169.82 41.98, 44.21 -90.47, -9.61 54.08, 84.94 -94.37, 2.45 in-in in 8.4157 Saltbr-in 3.448 HRD-in -74.45, -44.2 66.06, 8.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -133.04, 131.77 APE9-dihe-in -79.69, 122.84 APE8-dihe-out -69.38, -1.04 APE8-rot-na 339.66 APE67-dihe-in -75.83, -3.81 -84.39, -12.82 APE12-dist-na 999.0 APE11-dist-na 21.9267 APE10-dist-na 19.8348 APE9-dist-out 11.6466 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 B 317.0 282.0 23 30 23 7 [[478, 756]] 1.0 4rwk Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3C4FA P11362 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.1138 13.3182 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.8662 Saltbr-out 4.6321 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.0691 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.2924 APE11-dist-na 21.1206 APE10-dist-na 19.3954 APE9-dist-out 11.7567 C488A None None XRAY 2.07 0.213 0.264 A 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3C4FB P11362 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.1863 13.0956 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.8308 Saltbr-in 3.2478 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.9335 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.3702 APE11-dist-na 21.2959 APE10-dist-na 19.6706 APE9-dist-out 11.6434 C488A None None XRAY 2.07 0.213 0.264 B 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3RHXA P11362 464 764 822.0 3RH:2 Type1.5_Back Inactive DFGin 5.2319 13.4239 BLAplus -115.51, 162.57 65.19, 24.13 -75.33, -9.38 51.51, 92.3 -110.55, 8.31 in-in in 7.9108 Saltbr-in 2.7108 HRD-in -70.15, -54.52 80.53, -17.3 in-out-out SNCioo out-out ActLoopNT-out 8.9538 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.48, 163.59 APE9-dihe-in -103.14, 115.59 APE8-dihe-out -45.87, -31.01 APE8-rot-na 329.03 APE67-dihe-in -73.43, -8.98 -55.07, -22.7 APE12-dist-na 19.7705 APE11-dist-na 20.9378 APE10-dist-na 19.6197 APE9-dist-out 11.6966 C488A,C584S None None XRAY 2.01 0.205 0.262 A 306.0 289.0 12 30 30 0 [[478, 756]] 1.0 3rhx Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3RHXB P11362 461 761 822.0 3RH:1 Type1.5_Back Inactive DFGin 5.2781 13.0536 BLAplus -115.52, 168.31 59.14, 31.22 -88.71, -15.14 56.2, 82.95 -99.2, 10.03 in-in in 7.9397 Saltbr-in 2.9816 HRD-in -72.09, -51.52 83.53, -18.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.0, 155.03 APE9-dihe-in -98.71, 116.74 APE8-dihe-out -54.04, -23.88 APE8-rot-na 324.24 APE67-dihe-in -72.41, -9.32 -62.62, -17.17 APE12-dist-na 20.0916 APE11-dist-na 21.3945 APE10-dist-na 19.8352 APE9-dist-out 11.6213 C488A,C584S None None XRAY 2.01 0.205 0.262 B 306.0 275.0 26 30 24 6 [[478, 756]] 1.0 3rhx Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5A4CA P11362 464 765 822.0 XOJ:61774 Type1.5_Back Inactive DFGin 5.0481 13.267 BLAplus -116.37, 165.87 49.91, 42.78 -84.97, -10.47 49.36, 85.77 -124.76, 35.25 in-in in 7.785 Saltbr-in 2.7726 HRD-in -70.73, -50.48 78.51, -17.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.99, 158.13 APE9-dihe-in -97.5, 110.29 APE8-dihe-out -57.36, -20.43 APE8-rot-na 331.74 APE67-dihe-in -71.92, -10.57 -60.66, -19.9 APE12-dist-na 19.8611 APE11-dist-na 20.9953 APE10-dist-na 19.4954 APE9-dist-out 11.8058 C488A,C584S None None XRAY 2.09 0.197 0.235 A 307.0 294.0 8 30 24 6 [[478, 756]] 1.0 5a4c Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5A4CB P11362 461 765 822.0 XOJ:61772 Type1.5_Back Inactive DFGin 4.9967 13.1633 BLAplus -119.35, 160.02 53.79, 37.21 -79.91, -19.99 52.56, 81.88 -121.98, 47.25 in-in in 7.6662 Saltbr-in 2.8745 HRD-in -70.85, -51.35 80.75, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.16, 158.77 APE9-dihe-in -96.18, 111.18 APE8-dihe-out -54.21, -24.18 APE8-rot-na 331.2 APE67-dihe-in -62.46, -9.6 -52.41, -31.86 APE12-dist-na 20.0808 APE11-dist-na 21.2572 APE10-dist-na 19.71 APE9-dist-out 11.6301 C488A,C584S None None XRAY 2.09 0.197 0.235 B 307.0 284.0 21 30 25 5 [[478, 756]] 1.0 5a4c Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4NK9B P11362 460 765 822.0 2K5:802 Type1.5_Back Inactive DFGin 5.8249 13.2193 BLAplus -122.38, 146.16 46.72, 66.95 -88.33, 79.62 27.47, 86.37 49.01, 999.0 in-in in 8.0414 Saltbr-in 3.3685 HRD-in -55.1, -51.05 76.42, -8.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.43, 153.75 APE9-dihe-in -96.17, 112.02 APE8-dihe-out -57.11, -19.43 APE8-rot-na 333.43 APE67-dihe-in -71.52, -2.84 -61.88, -22.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.7726 C488A,C584S None None XRAY 2.57 0.209 0.262 B 309.0 282.0 24 30 22 8 [[478, 756]] 1.0 4nk9 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4V05A P11362 464 765 822.0 66T:1769 Type1.5_Back Inactive DFGin 5.4734 13.4201 BLAplus -110.72, 173.08 50.09, 39.57 -95.62, -19.67 60.09, 83.48 -87.99, 3.34 in-in in 8.0484 Saltbr-in 2.7499 HRD-in -64.72, -51.32 77.65, -23.6 in-out-out SNCioo out-out ActLoopNT-out 8.3021 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.91, 158.86 APE9-dihe-in -104.86, 116.5 APE8-dihe-out -57.09, -23.19 APE8-rot-na 335.63 APE67-dihe-in -66.78, -18.31 -54.95, -24.99 APE12-dist-na 20.8412 APE11-dist-na 21.8076 APE10-dist-na 19.9108 APE9-dist-out 11.6016 None None None XRAY 2.57 0.196 0.256 A 309.0 287.0 15 30 26 4 [[478, 756]] 1.0 4v05 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4V05B P11362 459 764 822.0 66T:1767 Type1.5_Back Inactive DFGin 5.4267 13.0724 BLAplus -110.08, 173.06 48.31, 47.35 -106.86, -10.85 58.74, 86.16 -77.17, -18.0 in-in in 7.8311 Saltbr-in 2.9832 HRD-in -65.29, -47.82 74.06, -21.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.03, 160.1 APE9-dihe-in -100.97, 109.95 APE8-dihe-out -53.4, -23.19 APE8-rot-na 333.98 APE67-dihe-in -59.05, -11.55 -51.93, -35.21 APE12-dist-na 21.3913 APE11-dist-na 22.0888 APE10-dist-na 20.5381 APE9-dist-out 11.4653 None None None XRAY 2.57 0.196 0.256 B 309.0 286.0 20 30 26 4 [[478, 756]] 1.0 4v05 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5EW8A P11362 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.9481 13.2646 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.9544 Saltbr-in 2.8007 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.0673 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.3705 APE11-dist-na 20.7434 APE10-dist-na 19.2162 APE9-dist-out 11.8815 None None None XRAY 1.63 0.186 0.206 A 309.0 291.0 11 30 30 0 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5EW8B P11362 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.0015 13.1238 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.8796 Saltbr-in 2.8072 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.3799 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.9019 APE11-dist-na 21.1689 APE10-dist-na 19.6545 APE9-dist-out 11.7665 None None None XRAY 1.63 0.186 0.206 B 309.0 290.0 15 30 28 2 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 2FGIA P11362 464 762 822.0 PD1:1001 Type1.5_Back Inactive DFGin 5.1208 13.4271 BLAplus -112.68, 157.47 60.87, 36.89 -81.98, -32.37 53.09, 90.73 -98.47, 17.45 in-in in 7.7469 Saltbr-in 2.9011 HRD-in -72.72, -53.18 83.95, -27.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -126.75, 157.3 APE9-dihe-in -97.93, 112.9 APE8-dihe-out -58.5, -25.56 APE8-rot-na 326.54 APE67-dihe-in -72.23, -8.06 -59.01, -20.89 APE12-dist-na 19.9221 APE11-dist-na 21.1754 APE10-dist-na 19.3215 APE9-dist-out 11.5439 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 A 310.0 274.0 25 30 28 2 [[478, 756]] 1.0 2fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 2FGIB P11362 461 761 822.0 PD1:1000 Type1.5_Back Inactive DFGin 5.0651 13.2083 BLAplus -127.21, 161.09 62.19, 18.94 -71.59, -20.95 56.29, 90.56 -106.4, 12.05 in-in in 7.7763 Saltbr-in 3.0664 HRD-in -62.08, -49.35 70.47, -0.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.38, 171.1 APE9-dihe-in -103.55, 110.23 APE8-dihe-out -52.66, -22.87 APE8-rot-na 324.05 APE67-dihe-in -65.07, -15.18 -62.56, -23.42 APE12-dist-na 999.0 APE11-dist-na 20.1947 APE10-dist-na 19.4561 APE9-dist-out 11.6548 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 B 310.0 272.0 29 30 21 9 [[478, 756]] 1.0 2fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5B7VA P11362 464 763 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.579 13.1223 BLAplus -124.02, 164.1 56.03, 35.18 -83.98, -18.11 54.48, 82.39 -93.9, 14.98 in-in in 7.6751 Saltbr-in 3.0247 HRD-in -66.75, -56.97 82.51, -19.31 in-out-out SNCioo out-out ActLoopNT-out 8.5813 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.75, 145.14 APE9-dihe-in -88.05, 111.6 APE8-dihe-out -54.86, -24.86 APE8-rot-na 336.86 APE67-dihe-in -69.24, -8.96 -56.43, -23.01 APE12-dist-na 20.9664 APE11-dist-na 21.6298 APE10-dist-na 19.6578 APE9-dist-out 12.0193 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 A 310.0 282.0 18 30 27 3 [[478, 756]] 1.0 5b7v Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4WUNA P11362 465 765 822.0 66T:801 Type1.5_Back Inactive DFGin 5.3591 13.2871 BLAplus -114.51, 167.45 61.45, 33.19 -92.75, -3.72 56.8, 81.8 -94.63, -9.82 in-in in 7.9245 Saltbr-in 2.9429 HRD-in -77.57, -50.47 80.03, -11.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -31.68 APE8-rot-na 335.8 APE67-dihe-in -71.2, -7.75 -54.8, -30.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.65 0.226 0.247 A 311.0 282.0 19 30 12 18 [[478, 756]] 1.0 4wun Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4WUNB P11362 461 762 822.0 66T:801 Type1.5_Back Inactive DFGin 5.2393 13.1038 BLAplus -116.49, 163.26 61.87, 38.6 -99.56, -5.62 55.6, 83.98 -99.35, -2.08 in-in in 7.7038 Saltbr-in 2.6666 HRD-in -74.96, -47.89 70.35, -11.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 81.94 APE8-dihe-out -59.03, -20.07 APE8-rot-na 4.38 APE67-dihe-in -66.47, -11.9 -63.08, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2021 None None None XRAY 1.65 0.226 0.247 B 311.0 268.0 34 30 13 17 [[478, 756]] 1.0 4wun Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5UR1A P11362 464 765 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.4257 13.5195 BLAplus -105.89, 156.77 50.9, 45.08 -90.42, 1.33 56.15, 80.94 -119.23, 19.57 in-in in 8.1192 Saltbr-in 2.8741 HRD-in -68.09, -57.16 83.23, -8.89 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -37.48 APE8-rot-na 0.79 APE67-dihe-in -68.25, -11.12 -55.14, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 A 311.0 278.0 24 30 12 18 [[478, 756]] 1.0 5ur1 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C18A P11362 465 765 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.4358 13.4677 BLAplus -111.24, 164.85 45.25, 45.5 -89.65, 12.35 52.19, 85.8 -112.52, 6.73 in-in in 8.1148 Saltbr-in 2.9779 HRD-in -70.43, -53.82 83.18, -8.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.11 APE8-rot-na 0.21 APE67-dihe-in -78.22, -8.43 -50.66, -26.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 A 311.0 276.0 25 30 12 18 [[478, 756]] 1.0 6c18 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C19A P11362 464 765 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.2602 13.4424 BLAplus -115.0, 156.31 53.23, 42.1 -90.35, 7.6 54.35, 87.97 -114.31, 9.09 in-in in 7.9996 Saltbr-in 2.7593 HRD-in -69.01, -56.23 81.64, -20.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 102.7 APE8-dihe-out -60.85, -19.74 APE8-rot-na 1.27 APE67-dihe-in -75.51, -3.9 -52.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.3194 None None None XRAY 2.12 0.207 0.239 A 311.0 276.0 26 30 13 17 [[478, 756]] 1.0 6c19 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C19B P11362 464 762 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.4245 13.2752 BLAplus -112.97, 152.62 61.65, 40.35 -91.96, -0.71 58.29, 80.73 -101.35, 18.35 in-in in 7.8884 Saltbr-in 2.6766 HRD-in -74.47, -50.19 73.43, -16.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 88.31 APE8-dihe-out -50.83, -20.72 APE8-rot-na 330.47 APE67-dihe-in -67.26, -8.41 -54.06, -29.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2189 None None None XRAY 2.12 0.207 0.239 B 311.0 264.0 35 30 13 17 [[478, 756]] 1.0 6c19 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C1BA P11362 465 765 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.481 13.4939 BLAplus -108.99, 153.45 58.08, 39.21 -83.57, -0.28 58.99, 81.41 -115.03, 23.43 in-in in 7.9616 Saltbr-in 2.7136 HRD-in -69.38, -56.84 85.63, -18.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.26 APE8-rot-na 2.4 APE67-dihe-in -77.29, -7.48 -43.43, -29.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.0 0.222 0.255 A 311.0 265.0 36 30 12 18 [[478, 756]] 1.0 6c1b Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C1BB P11362 463 762 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.3899 13.1727 BLAplus -111.61, 149.0 60.67, 36.26 -77.03, -12.36 51.44, 84.41 -47.03, -51.79 in-in in 7.7468 Saltbr-in 2.7171 HRD-in -68.12, -50.23 87.75, -19.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 84.87 APE8-dihe-out -57.93, -21.43 APE8-rot-na 10.08 APE67-dihe-in -70.65, -8.86 -55.2, -24.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.3082 C488A,C584S None None XRAY 2.0 0.222 0.255 B 311.0 256.0 44 30 13 17 [[478, 756]] 1.0 6c1b Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C1CA P11362 465 765 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.567 13.4933 BLAplus -110.74, 156.89 46.01, 46.87 -92.39, 20.43 55.59, 84.88 -142.57, 39.38 in-in in 8.0726 Saltbr-in 2.7841 HRD-in -74.71, -57.54 87.89, -21.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.9 APE8-rot-na 351.03 APE67-dihe-in -75.96, -1.2 -53.74, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.15 0.228 0.27 A 311.0 276.0 25 30 12 18 [[478, 756]] 1.0 6c1c Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C1CB P11362 463 763 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.2544 13.1457 BLAplus -106.04, 150.67 54.89, 44.71 -87.15, 1.28 50.78, 77.72 -105.41, 5.99 in-in in 7.7196 Saltbr-in 2.6179 HRD-in -67.33, -48.84 84.75, -22.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.16 APE8-dihe-out -62.72, -16.38 APE8-rot-na 19.67 APE67-dihe-in -70.81, -7.72 -62.98, -22.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4111 C488A,C584S None None XRAY 2.15 0.228 0.27 B 311.0 267.0 34 30 14 16 [[478, 756]] 1.0 6c1c Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C1OA P11362 464 765 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.3668 13.4758 BLAplus -110.66, 158.04 49.97, 55.76 -104.93, -8.0 57.72, 84.41 -107.33, 33.26 in-in in 7.7506 Saltbr-in 2.9138 HRD-in -67.38, -50.88 76.07, -0.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.74 APE8-dihe-out -57.13, -28.25 APE8-rot-na 348.02 APE67-dihe-in -72.73, -9.95 -55.13, -30.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.0802 C488A,C584S None None XRAY 2.29 0.239 0.276 A 311.0 280.0 22 30 13 17 [[478, 756]] 1.0 6c1o Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C1OB P11362 464 763 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.2521 13.3533 BLAplus -111.97, 154.41 51.29, 49.54 -91.74, -22.47 56.2, 81.11 -92.83, 58.93 in-in in 7.9163 Saltbr-in 3.1743 HRD-in -68.78, -49.64 75.13, -1.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.32 APE8-rot-na 337.06 APE67-dihe-in -73.03, -7.64 -66.65, -25.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.29 0.239 0.276 B 311.0 262.0 38 30 12 18 [[478, 756]] 1.0 6c1o Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6MZQA P11362 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.0992 13.2584 BLAplus -119.38, 163.65 62.35, 33.69 -91.12, -0.33 55.27, 84.16 -120.86, 13.76 in-in in 7.9486 Saltbr-in 2.6775 HRD-in -73.6, -55.96 80.43, -5.0 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.61 APE8-rot-na 334.89 APE67-dihe-in -72.0, -8.25 -68.04, -26.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 A 311.0 277.0 24 30 12 18 [[478, 756]] 1.0 6mzq Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6MZQB P11362 462 761 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.2291 13.0604 BLAplus -109.43, 157.46 65.55, 34.29 -83.47, -21.73 59.11, 82.16 -85.45, 999.0 in-in in 7.7832 Saltbr-in 2.8499 HRD-in -69.06, -55.52 76.96, -3.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -39.35 APE8-rot-na 334.65 APE67-dihe-in -70.64, -10.51 -51.58, -30.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 B 311.0 260.0 40 30 11 19 [[478, 756]] 1.0 6mzq Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWJA P11362 458 764 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.2638 13.5569 BLAplus -111.1, 165.72 44.3, 59.14 -104.5, -7.94 52.98, 85.2 -108.93, 18.9 in-in in 8.0637 Saltbr-in 3.1247 HRD-in -76.03, -43.68 72.99, -8.16 in-out-out SNCioo out-out ActLoopNT-out 7.9816 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.41, 138.95 APE9-dihe-in -108.01, 100.05 APE8-dihe-out -61.04, -14.23 APE8-rot-na 22.4 APE67-dihe-in -81.18, -2.01 -65.12, -23.42 APE12-dist-na 19.4256 APE11-dist-na 20.4566 APE10-dist-na 17.046 APE9-dist-out 11.3201 C488A,C584S None None XRAY 2.489 0.204 0.25 A 317.0 306.0 1 30 29 1 [[478, 756]] 1.0 4rwj Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWJB P11362 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.3065 13.0754 BLAplus -111.81, 166.65 44.09, 58.11 -104.8, -5.62 52.57, 84.61 -105.75, 19.27 in-in in 7.9338 Saltbr-in 2.8347 HRD-in -75.88, -44.44 70.84, -6.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.6, 139.99 APE9-dihe-in -106.55, 102.92 APE8-dihe-out -58.58, -14.6 APE8-rot-na 336.03 APE67-dihe-in -80.58, -2.45 -66.06, -21.44 APE12-dist-na 999.0 APE11-dist-na 21.7066 APE10-dist-na 18.4779 APE9-dist-out 11.5466 C488A,C584S None None XRAY 2.489 0.204 0.25 B 317.0 282.0 23 30 20 10 [[478, 756]] 1.0 4rwj Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3GQLA P11362 463 774 822.0 GQL:1 Type1.5_Back Inactive DFGin 5.2465 12.9895 BLAplus -123.12, 162.21 54.12, 42.77 -89.74, -13.17 56.15, 71.6 -109.47, 50.5 in-in in 7.9032 Saltbr-in 2.8342 HRD-in -61.52, -47.63 72.57, -4.79 in-out-out SNCioo out-out ActLoopNT-out 8.9245 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -142.49, 22.73 APE9-dihe-out 65.92, 53.77 APE8-dihe-out -55.03, -39.73 APE8-rot-na 329.92 APE67-dihe-in -69.54, -5.25 -36.43, -34.58 APE12-dist-na 16.3214 APE11-dist-na 15.2502 APE10-dist-na 15.9989 APE9-dist-out 11.3151 C488A None None XRAY 2.8 0.252 0.289 A 326.0 287.0 25 30 18 12 [[478, 756]] 1.0 3gql Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3TT0A P11362 461 765 822.0 07J:1 Type1.5_Back Inactive DFGin 5.2541 13.6387 BLAplus -115.26, 155.31 53.22, 40.23 -81.24, -26.95 55.14, 87.79 -91.68, 21.07 in-in in 7.9148 Saltbr-in 3.1056 HRD-in -69.95, -51.8 74.05, -16.9 in-out-out SNCioo out-out ActLoopNT-out 7.6141 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.94, 147.79 APE9-dihe-in -106.75, 107.95 APE8-dihe-out -68.73, -19.6 APE8-rot-na 342.28 APE67-dihe-in -78.56, -18.08 -54.41, -25.03 APE12-dist-na 17.1023 APE11-dist-na 19.4702 APE10-dist-na 16.7308 APE9-dist-out 11.0711 C584S None None XRAY 2.8 0.207 0.261 A 382.0 305.0 0 30 30 0 [[478, 756]] 1.0 3tt0 Homo sapiens TYR_FGFR1_HUMAN TYR 3e-104 353.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3TT0B P11362 459 763 822.0 07J:1 Type1.5_Back Inactive DFGin 5.3817 13.3069 BLAplus -116.49, 155.58 53.39, 40.81 -79.81, -25.38 49.88, 91.88 -91.88, 20.46 in-in in 7.8477 Saltbr-in 3.0405 HRD-in -67.66, -50.02 73.72, -9.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 146.21 APE8-rot-na 352.76 APE67-dihe-out -93.95, -12.68 76.26, -23.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.8 0.207 0.261 B 382.0 272.0 33 30 13 17 [[478, 756]] 1.0 3tt0 Homo sapiens TYR_FGFR1_HUMAN TYR 3e-104 353.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8Y22A P11362 459 762 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 5.1055 13.1789 BLAplus -113.25, 160.17 59.08, 34.01 -79.21, -14.36 51.54, 87.27 -109.45, 13.99 in-in in 7.9825 Saltbr-in 2.7993 HRD-in -70.73, -44.6 68.63, 0.76 in-out-out SNCioo out-out ActLoopNT-out 9.0288 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.2, 162.84 APE9-dihe-in -99.13, 115.53 APE8-dihe-out -57.19, -22.1 APE8-rot-na 334.84 APE67-dihe-in -76.32, -7.85 -61.99, -21.14 APE12-dist-na 19.6449 APE11-dist-na 20.8827 APE10-dist-na 19.4784 APE9-dist-out 11.673 C584S None None XRAY 2.792 0.197 0.26 A 308.0 288.0 16 30 26 4 [[478, 756]] 1.0 8y22 Homo sapiens TYR_FGFR1_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8Y22B P11362 463 765 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 4.9267 13.3865 BLAplus -106.53, 165.87 49.37, 36.23 -76.81, -19.53 50.68, 85.1 -111.75, 14.63 in-in in 8.1525 Saltbr-in 2.7928 HRD-in -74.01, -46.1 72.79, 0.75 in-out-out SNCioo out-out ActLoopNT-out 8.596 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.29, 150.81 APE9-dihe-in -94.3, 115.55 APE8-dihe-out -59.96, -16.81 APE8-rot-na 335.23 APE67-dihe-in -86.59, -1.86 -68.36, -9.3 APE12-dist-na 19.374 APE11-dist-na 20.9185 APE10-dist-na 19.1449 APE9-dist-out 11.7338 C584S None None XRAY 2.792 0.197 0.26 B 308.0 291.0 12 30 30 0 [[478, 756]] 1.0 8y22 Homo sapiens TYR_FGFR1_HUMAN TYR 2e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6NVLA P11362 463 765 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.1279 13.3113 BLAplus -119.52, 157.53 59.31, 34.82 -84.42, -16.16 59.33, 82.45 -101.42, 33.52 in-in in 7.5898 Saltbr-in 2.8655 HRD-in -75.42, -53.52 80.47, -2.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.68, 147.97 APE9-dihe-in -112.42, 91.75 APE8-dihe-out -47.21, -34.96 APE8-rot-na 327.61 APE67-dihe-in -66.06, -15.18 -49.22, -31.67 APE12-dist-na 17.2866 APE11-dist-na 20.5601 APE10-dist-na 17.1824 APE9-dist-out 11.6245 C584S None None XRAY 2.7 0.215 0.263 A 309.0 280.0 23 30 21 9 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6NVLB P11362 461 761 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.2902 13.112 BLAplus -110.71, 154.52 49.9, 58.02 -103.43, -14.13 54.73, 82.29 -99.41, 13.49 in-in in 7.6235 Saltbr-in 3.0252 HRD-in -62.36, -64.19 100.95, -30.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.63 APE8-rot-na 324.79 APE67-dihe-in -73.34, -7.41 -51.06, -32.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 B 309.0 263.0 38 30 12 18 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6NVLC P11362 465 761 822.0 XL6:801 Type1.5_Back Inactive DFGin 5.3955 13.3962 BLAplus -121.16, 162.24 42.87, 55.81 -103.48, -8.54 57.38, 81.17 -97.02, -26.48 in-in in 7.522 Saltbr-in 3.1539 HRD-in -69.09, -49.97 76.47, -2.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -35.16 APE8-rot-na 328.72 APE67-dihe-in -78.06, -0.48 -64.76, -24.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 C 309.0 265.0 32 30 21 9 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6NVLD P11362 471 762 822.0 XL6:804 Type1.5_Back Inactive DFGin 5.1576 13.3104 BLAplus -117.28, 161.88 52.71, 45.04 -93.07, -6.01 60.08, 84.31 -96.46, -42.94 in-none in 7.3629 Saltbr-none 999.0 HRD-in -74.01, -57.04 84.17, -3.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.3, 154.56 APE9-dihe-in -112.92, 85.91 APE8-dihe-out -57.48, -12.84 APE8-rot-na 334.14 APE67-dihe-in -78.36, -8.15 -65.38, -24.93 APE12-dist-na 16.4701 APE11-dist-na 19.4008 APE10-dist-na 16.585 APE9-dist-out 11.3348 C584S None None XRAY 2.7 0.215 0.263 D 309.0 269.0 23 30 21 9 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7WCLA P11362 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.0323 13.5114 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.2337 Saltbr-in 2.9434 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.9796 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.7251 APE11-dist-na 19.0668 APE10-dist-na 16.2264 APE9-dist-out 11.2235 C584S None None XRAY 2.495 0.195 0.23 A 310.0 306.0 0 30 30 0 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 7WCLB P11362 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.6863 13.2974 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.3808 Saltbr-in 2.8041 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.6055 APE10-dist-na 19.4985 APE9-dist-out 11.4021 C584S None None XRAY 2.495 0.195 0.23 B 310.0 285.0 21 30 22 8 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8XLOA P11362 462 764 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.3499 13.4604 BLAplus -120.07, 167.95 56.19, 37.83 -98.04, 4.56 56.68, 90.6 -112.93, 25.35 in-in in 7.9829 Saltbr-in 3.258 HRD-out -75.5, 142.74 -82.57, -37.38 in-out-out SNCioo out-out ActLoopNT-out 7.2004 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.57, 158.46 APE9-dihe-in -97.47, 110.21 APE8-dihe-out -58.39, -18.54 APE8-rot-na 19.21 APE67-dihe-in -81.65, 0.42 -62.39, -18.82 APE12-dist-na 20.741 APE11-dist-na 21.9456 APE10-dist-na 20.2119 APE9-dist-out 11.7779 C584S None None XRAY 2.36 0.21 0.255 A 310.0 293.0 10 30 30 0 [[478, 756]] 1.0 8xlo Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8XLOB P11362 458 763 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.5876 13.1874 BLAplus -122.66, 168.69 59.17, 27.93 -79.17, -12.14 48.47, 88.63 -115.21, 3.75 in-in in 7.7683 Saltbr-in 2.8826 HRD-out -89.09, 129.19 -58.3, -36.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.09, 159.35 APE9-dihe-in -98.63, 108.84 APE8-dihe-out -54.34, -25.08 APE8-rot-na 331.75 APE67-dihe-in -70.85, 2.53 -59.01, -24.97 APE12-dist-na 19.448 APE11-dist-na 20.7383 APE10-dist-na 19.2996 APE9-dist-out 11.7119 C584S None None XRAY 2.36 0.21 0.255 B 310.0 287.0 19 30 24 6 [[478, 756]] 1.0 8xlo Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8XZ7B P11362 461 765 822.0 A1LWW:60804 Type1.5_Back Inactive DFGin 5.2771 13.4856 BLAplus -115.92, 158.14 64.67, 33.78 -87.5, -12.64 58.12, 85.71 -91.55, 13.39 in-in in 8.2684 Saltbr-in 2.9739 HRD-in -72.69, -49.53 74.85, -11.34 in-out-out SNCioo out-out ActLoopNT-out 7.6983 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -73.13, 157.52 APE9-dihe-in -120.81, 83.94 APE8-dihe-out -59.26, -16.83 APE8-rot-na 351.23 APE67-dihe-in -76.52, -7.27 -60.13, -24.1 APE12-dist-na 17.8835 APE11-dist-na 19.5813 APE10-dist-na 16.7541 APE9-dist-out 11.0899 C584S None None XRAY 1.75 0.188 0.225 B 310.0 303.0 2 30 30 0 [[478, 756]] 1.0 8xz7 Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6MZWA P11362 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 4.8216 13.4005 BLAplus -122.44, 164.99 57.07, 40.5 -90.84, 9.02 55.25, 82.2 -134.07, 2.85 in-in in 8.0037 Saltbr-in 2.8192 HRD-in -69.57, -56.52 83.74, -8.47 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.34 APE8-rot-na 329.11 APE67-dihe-in -82.69, 5.42 -51.99, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 A 311.0 282.0 20 30 12 18 [[478, 756]] 1.0 6mzw Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5VNDA P11362 463 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.2281 13.4249 BLAplus -118.27, 161.79 56.96, 41.78 -93.83, -18.18 57.16, 83.64 -76.46, -2.88 in-in in 7.7058 Saltbr-in 3.0109 HRD-in -76.4, -51.16 70.96, 1.97 in-out-out SNCioo out-out ActLoopNT-out 8.3852 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.26, 154.9 APE9-dihe-in -95.33, 115.63 APE8-dihe-out -58.5, -20.28 APE8-rot-na 328.5 APE67-dihe-in -71.98, -7.89 -57.67, -20.31 APE12-dist-na 20.2467 APE11-dist-na 21.3871 APE10-dist-na 19.7461 APE9-dist-out 11.7966 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 A 309.0 302.0 1 30 29 1 [[478, 756]] 1.0 5vnd Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5VNDB P11362 460 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.2864 13.2188 BLAplus -116.66, 159.84 60.5, 40.74 -88.83, -28.65 56.85, 87.63 -76.11, -9.05 in-in in 7.6432 Saltbr-in 3.1348 HRD-in -75.25, -50.66 71.68, -1.94 in-out-out SNCioo out-out ActLoopNT-out 7.9716 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.48, 159.45 APE9-dihe-in -96.83, 113.88 APE8-dihe-out -57.87, -23.88 APE8-rot-na 336.6 APE67-dihe-in -71.96, -8.45 -53.4, -22.22 APE12-dist-na 20.1684 APE11-dist-na 21.3989 APE10-dist-na 19.9278 APE9-dist-out 11.6497 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 B 309.0 295.0 11 30 30 0 [[478, 756]] 1.0 5vnd Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6P68A P11362 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.5681 13.2974 BLAplus -124.18, 155.54 63.3, 48.78 -90.25, -51.15 37.68, 89.45 -72.78, 42.85 in-in in 8.4634 Saltbr-in 3.0682 HRD-in -82.33, -55.3 90.45, -28.65 in-out-out SNCioo out-out ActLoopNT-out 9.2537 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.44, 166.09 APE9-dihe-in -115.93, 115.43 APE8-dihe-out -43.99, -17.59 APE8-rot-na 319.34 APE67-dihe-in -77.38, -22.95 -75.44, -11.63 APE12-dist-na 20.7136 APE11-dist-na 21.7563 APE10-dist-na 19.6548 APE9-dist-out 11.5919 C488A,Y563C None None XRAY 2.9 0.23 0.303 A 309.0 287.0 15 30 27 3 [[478, 756]] 1.0 6p68 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6P68B P11362 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.4999 13.3623 BLAplus -127.31, 162.51 46.96, 56.83 -101.23, -42.4 47.99, 77.97 -84.27, 46.6 in-in in 7.7578 Saltbr-in 3.3016 HRD-in -84.02, -53.61 84.39, -26.28 in-out-out SNCioo out-out ActLoopNT-out 8.8458 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.18, 175.15 APE9-dihe-in -113.49, 131.98 APE8-dihe-out -57.6, -24.27 APE8-rot-na 330.67 APE67-dihe-in -68.05, -15.43 -68.07, -21.93 APE12-dist-na 20.753 APE11-dist-na 22.1816 APE10-dist-na 20.562 APE9-dist-out 11.6663 C488A,Y563C None None XRAY 2.9 0.23 0.303 B 309.0 286.0 16 30 27 3 [[478, 756]] 1.0 6p68 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6P68C P11362 463 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.8214 13.2159 BLAplus -111.29, 171.43 44.74, 37.04 -76.15, -58.04 39.05, 94.26 -70.98, 63.26 in-in in 7.3725 Saltbr-in 2.8855 HRD-in -80.62, -45.97 77.53, -19.73 in-out-out SNCioo out-out ActLoopNT-out 8.2897 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.73, 161.83 APE9-dihe-in -111.63, 125.51 APE8-dihe-out -59.61, -24.78 APE8-rot-na 332.23 APE67-dihe-in -70.27, -21.8 -56.16, -23.37 APE12-dist-na 20.3359 APE11-dist-na 21.4418 APE10-dist-na 19.2263 APE9-dist-out 11.3243 C488A,Y563C None None XRAY 2.9 0.23 0.303 C 309.0 286.0 15 30 27 3 [[478, 756]] 1.0 6p68 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6P69A P11362 462 765 822.0 O21:804 Type1.5_Back Inactive DFGin 5.2934 13.3317 BLAplus -116.62, 153.51 68.44, 36.07 -94.14, -3.31 60.05, 82.99 -102.25, 17.21 in-in in 7.6778 Saltbr-in 2.8285 HRD-in -76.03, -50.91 79.25, -13.3 in-out-out SNCioo out-out ActLoopNT-out 6.9198 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.91, 156.78 APE9-dihe-in -97.6, 112.94 APE8-dihe-out -56.34, -25.16 APE8-rot-na 341.33 APE67-dihe-in -73.31, -6.91 -51.65, -21.86 APE12-dist-na 20.8524 APE11-dist-na 22.1533 APE10-dist-na 20.3724 APE9-dist-out 11.5954 C488A,Y563C None None XRAY 2.2 0.189 0.245 A 309.0 288.0 16 30 30 0 [[478, 756]] 1.0 6p69 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6P69B P11362 461 762 822.0 O21:804 Type1.5_Back Inactive DFGin 5.2379 12.9915 BLAplus -110.73, 150.1 69.98, 35.36 -92.92, -8.35 56.07, 83.61 -81.3, 13.2 in-in in 7.6744 Saltbr-in 2.7228 HRD-in -71.89, -48.99 79.15, -25.42 in-out-out SNCioo out-out ActLoopNT-out 7.4095 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.29, 160.07 APE9-dihe-in -97.38, 114.82 APE8-dihe-out -64.56, -21.47 APE8-rot-na 332.49 APE67-dihe-in -69.85, -7.92 -52.16, -22.61 APE12-dist-na 20.5217 APE11-dist-na 21.6862 APE10-dist-na 19.9636 APE9-dist-out 11.4536 C488A,Y563C None None XRAY 2.2 0.189 0.245 B 309.0 286.0 16 30 30 0 [[478, 756]] 1.0 6p69 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3KXXA P11362 461 765 822.0 No_ligand No_ligand Inactive DFGin 6.8887 14.2587 BLBminus -140.37, -169.46 63.26, 50.32 -78.18, 162.76 296.3, 66.09 151.64, -37.0 in-in in 7.0169 Saltbr-in 2.8305 HRD-out -100.04, 84.29 -55.69, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.55, 44.24 APE9-dihe-in -122.5, 136.32 APE8-dihe-in -50.57, 127.21 APE8-rot-na 327.84 APE67-dihe-in -76.36, 2.91 -67.27, -29.4 APE12-dist-na 14.3372 APE11-dist-na 9.735 APE10-dist-na 7.8605 APE9-dist-in 5.3467 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 A 317.0 305.0 0 30 30 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8JQIB P11362 463 769 822.0 No_ligand No_ligand Inactive DFGin 5.5799 13.7021 BLBplus -110.39, 162.0 66.1, 18.22 -83.81, 164.72 63.85, 90.92 69.71, 13.55 in-in in 8.1475 Saltbr-in 2.879 HRD-in -62.9, -42.83 68.84, -8.19 in-out-in SNCioi out-in ActLoopNT-out 7.7085 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.84, 130.26 APE9-dihe-in -65.71, 153.24 APE8-dihe-in -72.54, 69.48 APE8-rot-na 18.0 APE67-dihe-in -81.24, 0.42 -61.21, -30.47 APE12-dist-na 18.0042 APE11-dist-na 14.2329 APE10-dist-na 16.4083 APE9-dist-in 6.9708 None None None EM 4.1 999.0 999.0 B 822.0 307.0 0 30 30 0 [[478, 756]] 1.0 8jqi Homo sapiens TYR_FGFR1_HUMAN TYR 3e-103 351.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8YKIA P11362 464 762 822.0 A1LY1:60801 Type1 Inactive DFGin 5.6779 13.1891 BLBplus -127.03, 161.47 55.43, 32.07 -78.75, 135.31 51.37, 81.9 67.66, 33.8 in-in in 7.9961 Saltbr-in 3.2277 HRD-in -69.63, -52.14 73.54, -1.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.66 APE8-dihe-out -68.91, -19.3 APE8-rot-na 29.84 APE67-dihe-in -67.55, -18.75 -54.73, -36.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.0568 C488A None None XRAY 2.79 0.242 0.288 A 317.0 267.0 32 30 14 16 [[478, 756]] 1.0 8yki Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8YKIB P11362 461 761 822.0 A1LY1:60801 Type1 Inactive DFGin 5.8164 13.0018 BLBplus -127.51, 162.85 54.9, 31.45 -78.58, 134.89 51.65, 81.41 96.69, -107.12 in-in in 7.9675 Saltbr-in 3.2283 HRD-in -70.15, -51.98 73.59, -0.57 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.54 APE8-dihe-out -68.77, -19.51 APE8-rot-na 29.46 APE67-dihe-in -66.31, -19.61 -55.9, -35.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.131 C488A None None XRAY 2.79 0.242 0.288 B 317.0 264.0 37 30 13 17 [[478, 756]] 1.0 8yki Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 3GQLB P11362 463 765 822.0 GQL:1 Type1 Inactive DFGin 5.6088 13.296 BLBplus -128.62, 167.94 48.28, 62.54 -111.2, 147.65 41.12, 83.15 54.74, 40.27 in-in in 8.0883 Saltbr-in 2.95 HRD-in -58.11, -48.09 70.35, -6.25 in-out-none SNCion out-none ActLoopNT-out 8.8534 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.24 APE8-rot-na 35.42 APE67-dihe-in -73.56, 1.23 -76.55, -20.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 B 326.0 276.0 27 30 14 16 [[478, 756]] 1.0 3gql Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 8XZ7A P11362 458 765 822.0 A1LWW:60803 Type1 Inactive DFGin 5.5824 13.0234 BLBplus -119.64, 153.34 65.26, 30.33 -76.98, 170.32 51.66, 84.53 -174.68, 170.61 in-in in 8.2102 Saltbr-in 2.896 HRD-out -86.18, 131.57 -68.41, -19.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.72, 163.01 APE9-dihe-in -98.35, 111.69 APE8-dihe-out -59.15, -22.66 APE8-rot-na 330.38 APE67-dihe-in -69.43, -4.98 -58.15, -24.4 APE12-dist-na 25.2835 APE11-dist-na 26.4421 APE10-dist-na 23.9183 APE9-dist-out 11.3513 C584S None None XRAY 1.75 0.188 0.225 A 310.0 297.0 11 30 26 4 [[478, 756]] 1.0 8xz7 Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5ZV2A P11362 463 762 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.5677 14.1438 BLBplus -131.08, 166.37 55.4, 22.07 -76.03, 127.13 51.59, 83.66 103.79, -116.47 in-in in 7.8578 Saltbr-in 3.1426 HRD-in -69.2, -53.37 81.07, -9.59 in-out-out SNCioo out-out ActLoopNT-out 9.1847 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -156.95, 137.73 APE9-dihe-in -102.4, 101.23 APE8-dihe-out -65.35, -22.62 APE8-rot-na 30.52 APE67-dihe-in -64.41, -13.08 -61.44, -25.69 APE12-dist-na 18.7124 APE11-dist-na 21.0676 APE10-dist-na 17.8389 APE9-dist-out 12.1029 C488A None None XRAY 2.86 0.215 0.269 A 305.0 284.0 16 30 28 2 [[478, 756]] 1.0 5zv2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5ZV2B P11362 461 764 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.7346 13.3331 BLBplus -131.99, 168.42 59.16, 17.33 -69.91, 121.62 49.14, 91.18 109.73, -109.09 in-in in 7.949 Saltbr-in 2.8669 HRD-in -69.21, -53.97 80.59, -9.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 120.68 APE9-dihe-in -90.2, 111.18 APE8-dihe-out -62.93, -18.78 APE8-rot-na 29.94 APE67-dihe-in -66.68, -14.01 -56.35, -27.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.9258 APE9-dist-out 11.6098 C488A None None XRAY 2.86 0.215 0.269 B 305.0 281.0 23 30 20 10 [[478, 756]] 1.0 5zv2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4NK9A P11362 464 765 822.0 2K5:807 Type1.5_Back Inactive DFGin 5.6428 13.3579 BLBplus -109.95, 156.55 39.62, 77.0 -103.05, 153.56 28.96, 73.43 57.1, 999.0 in-in in 8.098 Saltbr-in 3.3631 HRD-in -55.46, -49.38 77.25, -13.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.12, 153.38 APE9-dihe-in -96.1, 111.38 APE8-dihe-out -57.95, -18.94 APE8-rot-na 334.9 APE67-dihe-in -71.02, -3.8 -60.59, -24.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8934 C488A,C584S None None XRAY 2.57 0.209 0.262 A 309.0 281.0 21 30 23 7 [[478, 756]] 1.0 4nk9 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5B7VB P11362 462 762 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.6766 12.94 BLBplus -116.05, 161.84 53.01, 39.08 -76.06, 133.86 41.64, 92.29 65.64, 39.87 in-in in 7.6165 Saltbr-in 3.029 HRD-in -64.13, -51.82 87.54, -28.51 in-out-out SNCioo out-out ActLoopNT-out 9.4405 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -94.62, 144.39 APE9-dihe-in -82.91, 115.57 APE8-dihe-out -50.0, -27.69 APE8-rot-na 330.02 APE67-dihe-in -70.22, -11.34 -61.05, -21.38 APE12-dist-na 999.0 APE11-dist-na 19.9984 APE10-dist-na 18.2427 APE9-dist-out 11.7021 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 B 310.0 277.0 24 30 24 6 [[478, 756]] 1.0 5b7v Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 5UR1B P11362 464 763 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.2909 13.2475 BLBplus -105.41, 154.97 53.57, 37.31 -77.11, 166.16 58.26, 86.17 69.33, 25.51 in-in in 7.6177 Saltbr-in 2.5963 HRD-in -63.24, -51.37 83.2, -13.32 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -28.36 APE8-rot-na 342.42 APE67-dihe-in -76.21, -4.72 -69.35, -13.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 B 311.0 265.0 35 30 12 18 [[478, 756]] 1.0 5ur1 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4RWLB P11362 458 764 822.0 3ZC:801 Type1.5_Back Inactive DFGin 5.5749 12.8603 BLBplus -118.6, 158.89 63.82, 31.02 -77.01, 152.77 46.13, 88.04 75.46, -144.53 in-in in 7.8641 Saltbr-in 2.7141 HRD-in -76.64, -55.25 80.83, -9.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.43, 164.04 APE9-dihe-in -102.17, 112.77 APE8-dihe-out -51.59, -26.38 APE8-rot-na 327.68 APE67-dihe-in -76.33, -6.25 -60.23, -17.85 APE12-dist-na 20.4616 APE11-dist-na 21.2659 APE10-dist-na 19.7485 APE9-dist-out 11.5255 C488A,C584S None None XRAY 2.193 0.209 0.256 B 317.0 285.0 22 30 24 6 [[478, 756]] 1.0 4rwl Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4F65A P11362 464 765 822.0 0S9:808 Type1 Inactive DFGin 5.6218 13.0799 None -116.38, 166.24 56.16, 50.99 -96.21, 999.0 35.52, 82.62 999.0, 999.0 in-in in 7.9758 Saltbr-in 2.9248 HRD-in -64.44, -52.01 69.63, -13.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.26, 142.02 APE9-dihe-in -87.5, 110.31 APE8-dihe-out -50.81, -23.5 APE8-rot-na 336.61 APE67-dihe-in -69.73, -13.19 -59.55, -23.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.26 0.204 0.235 A 309.0 279.0 23 30 20 10 [[478, 756]] 1.0 4f65 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4NKAB P11362 458 765 822.0 2K7:803 Type1 Inactive DFGin 4.9928 12.588 None -113.09, 172.85 51.3, 36.02 -81.11, 999.0 51.02, 79.07 999.0, 999.0 in-in in 7.7205 Saltbr-in 2.8187 HRD-in -68.57, -53.53 79.69, -21.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -99.94, 158.4 APE9-dihe-in -98.99, 111.75 APE8-dihe-out -53.76, -24.39 APE8-rot-na 331.5 APE67-dihe-in -68.26, -7.43 -55.44, -26.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.4239 C488A,C584S None None XRAY 2.19 0.2 0.228 B 309.0 287.0 21 30 24 6 [[478, 756]] 1.0 4nka Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4F65B P11362 460 763 822.0 0S9:808 Type1.5_Back Inactive DFGin 6.1724 11.7443 None -112.37, 28.01 -137.92, 136.63 -123.39, 999.0 315.19, 98.45 999.0, 999.0 in-in in 7.9279 Saltbr-in 2.9079 HRD-in -72.51, -42.53 62.62, -12.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.78, 143.47 APE9-dihe-in -85.99, 110.74 APE8-dihe-out -51.4, -22.91 APE8-rot-na 337.29 APE67-dihe-in -68.78, -13.01 -59.73, -24.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2572 C488A,C584S None None XRAY 2.26 0.204 0.235 B 309.0 279.0 25 30 23 7 [[478, 756]] 1.0 4f65 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6C18B P11362 466 762 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.466 13.1559 None -121.52, 157.51 52.39, 50.92 -96.25, 999.0 51.2, 88.67 999.0, 999.0 in-in in 8.0231 Saltbr-in 2.9239 HRD-in -68.59, -52.77 77.43, -7.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.06 APE8-rot-na 331.63 APE67-dihe-in -71.45, -6.87 -51.83, -28.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 B 311.0 255.0 42 30 10 20 [[478, 756]] 1.0 6c18 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 6MZWB P11362 463 762 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.2433 13.1911 None -113.61, 162.19 59.99, 41.93 -84.77, 999.0 49.28, 82.5 999.0, 999.0 in-in in 7.816 Saltbr-in 2.6843 HRD-in -70.89, -55.55 82.9, -7.56 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-na 29.6 APE67-dihe-in -68.26, -6.41 -48.51, -43.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 B 311.0 258.0 42 30 10 20 [[478, 756]] 1.0 6mzw Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4V04B P11362 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.8725 BBAminus -127.4, -173.98 -164.99, 120.92 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.0147 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.5141 APE11-dist-na 20.9701 APE10-dist-na 19.2978 APE9-dist-out 11.5913 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309.0 289.0 19 30 24 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4V01A P11362 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.6478 9.6834 None -136.22, -176.63 -157.46, 111.62 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.8519 Saltbr-in 2.8239 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.7272 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309.0 273.0 28 30 22 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4V01B P11362 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.4764 9.083 None -140.66, -178.05 -156.06, 123.42 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.9159 Saltbr-in 2.8067 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.8136 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309.0 275.0 28 30 22 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1 FGFR1_HUMAN 4V04A P11362 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.0506 10.3941 None -127.25, -179.24 -145.47, 116.11 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.8637 Saltbr-in 3.2056 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.6385 APE11-dist-na 21.0205 APE10-dist-na 19.3218 APE9-dist-out 11.7003 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309.0 293.0 10 30 24 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

TYR_FGFR1 (Fibroblast growth factor receptor 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name