TYR_FGFR1 (Fibroblast growth factor receptor 1)

Total number of chains: 145
Active chains: 3
Family: TYR
Uniprot: FGFR1_HUMAN
Kinase Domain Residues: 478 - 756
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 114 78.6% 9UHIA
DFGin BLBplus 11 7.6% 8JQIB
DFGin BLAminus 10 6.9% AF-P11362-K1A
DFGin None 5 3.4% 4NKAB
DFGout None 3 2.1% 4V04A
DFGin BLBminus 1 0.7% 3KXXA
DFGout BBAminus 1 0.7% 4V04B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
3GQIA 464 770 822.0 ACP:775 ATPlike Active DFGin 6.466 13.946 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.751 Saltbr-in 2.69 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.083 APE11-dist-na 11.258 APE10-dist-na 10.128 APE9-dist-in 7.137 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326 307 0 0 0 0 [[478, 756]] 1.0 3gqi TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
AF-P11362-K1A 470 764 822.0 No_ligand No_ligand Active DFGin 6.585 13.745 BLAminus -135.24, -172.55 53.83, 70.53 -87.91, 10.86 290.57, 95.64 -59.32, -30.75 in-in in 7.453 Saltbr-in 2.648 HRD-in -70.89, -43.2 66.63, -19.06 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.78, 130.17 APE9-dihe-in -137.78, 151.11 APE8-dihe-in -79.35, 77.49 APE8-rot-na 37.15 APE67-dihe-in -67.5, -12.86 -47.07, -41.3 APE12-dist-na 14.394 APE11-dist-na 9.931 APE10-dist-na 9.99 APE9-dist-in 6.506 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[478, 756]] 1.0 AF-P11362-K1 TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
AF-P11362-K3A 470 764 822.0 No_ligand No_ligand Active DFGin 6.146 13.521 BLAminus -139.78, -177.08 59.37, 66.68 -79.98, 12.43 289.81, 96.12 -59.82, -28.59 in-in in 7.906 Saltbr-in 2.659 HRD-in -80.49, -43.82 61.4, -3.43 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.53, 136.75 APE9-dihe-in -134.21, 129.98 APE8-dihe-in -82.7, 64.06 APE8-rot-na 35.6 APE67-dihe-in -69.03, -12.46 -46.62, -44.88 APE12-dist-na 13.461 APE11-dist-na 9.794 APE10-dist-na 8.155 APE9-dist-in 6.648 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[478, 756]] 1.0 AF-P11362-K3 TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3KXXB 460 764 822.0 No_ligand No_ligand Inactive DFGin 7.061 14.507 BLAminus -138.91, 177.11 64.42, 63.57 -90.83, 31.94 294.07, 81.15 -71.04, -30.05 in-in in 7.234 Saltbr-in 3.199 HRD-out -89.94, 81.9 -57.82, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.01, 74.51 APE9-dihe-in -144.18, 139.02 APE8-dihe-in -51.42, 121.01 APE8-rot-na 327.88 APE67-dihe-in -76.85, -17.4 -68.16, -22.5 APE12-dist-na 14.893 APE11-dist-na 10.36 APE10-dist-na 9.133 APE9-dist-in 5.752 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 B 317 305 0 0 0 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3KXXC 458 762 822.0 No_ligand No_ligand Inactive DFGin 7.139 13.992 BLAminus -138.07, -172.42 62.91, 62.15 -92.81, 13.58 296.2, 98.02 -70.01, -16.73 in-in in 7.243 Saltbr-in 2.637 HRD-out -88.37, 88.38 -55.25, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.88, 68.46 APE9-dihe-in -154.11, 147.86 APE8-dihe-in -47.33, 131.68 APE8-rot-na 28.97 APE67-dihe-in -56.58, -13.9 -82.3, -38.63 APE12-dist-na 15.086 APE11-dist-na 10.333 APE10-dist-na 8.947 APE9-dist-in 6.261 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 C 317 286 19 0 0 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3KXXD 458 762 822.0 No_ligand No_ligand Inactive DFGin 6.502 13.671 BLAminus -133.51, -161.48 51.6, 74.09 -99.67, 22.58 293.84, 93.72 -66.62, -32.71 in-in in 7.529 Saltbr-in 3.458 HRD-out -84.43, 73.53 -41.76, -24.93 in-in-in SNCiii in-in ActLoopNT-in 3.114 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.31, 77.29 APE9-dihe-in -147.89, 135.68 APE8-dihe-in -51.4, 116.54 APE8-rot-na 326.12 APE67-dihe-in -63.39, 3.02 -61.34, -39.64 APE12-dist-na 15.473 APE11-dist-na 10.561 APE10-dist-na 8.835 APE9-dist-in 6.24 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 D 317 286 19 0 0 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5FLFA 460 762 822.0 No_ligand No_ligand Inactive DFGin 6.566 13.921 BLAminus -130.07, -173.3 57.53, 81.51 -106.56, 20.58 287.47, 88.65 -65.69, -26.36 in-in in 7.061 Saltbr-in 2.623 HRD-in -77.09, -44.33 71.36, -17.68 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -122.27, 31.65 APE9-dihe-in -120.82, 141.16 APE8-dihe-in -55.6, 118.0 APE8-rot-na 17.74 APE67-dihe-in -68.76, -3.74 -51.76, -42.09 APE12-dist-na 14.969 APE11-dist-na 10.487 APE10-dist-na 8.045 APE9-dist-in 5.76 R675G None None XRAY 2.58 0.197 0.255 A 310 296 7 0 0 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5FLFB 460 764 822.0 No_ligand No_ligand Inactive DFGin 6.597 14.271 BLAminus -131.38, -174.56 57.69, 69.98 -91.26, 21.65 284.1, 89.91 -69.58, -18.15 in-in in 7.208 Saltbr-in 2.661 HRD-in -77.24, -42.46 70.08, -13.13 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.34, 21.86 APE9-dihe-in -108.05, 143.02 APE8-dihe-in -54.9, 122.45 APE8-rot-na 333.47 APE67-dihe-in -66.56, -8.26 -58.19, -40.45 APE12-dist-na 14.767 APE11-dist-na 10.342 APE10-dist-na 7.676 APE9-dist-in 5.588 R675G None None XRAY 2.58 0.197 0.255 B 310 292 13 0 0 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5FLFC 464 763 822.0 No_ligand No_ligand Inactive DFGin 6.879 14.904 BLAminus -128.63, -179.22 56.68, 76.02 -97.55, 23.96 288.87, 80.23 -64.42, -24.4 in-in in 7.867 Saltbr-in 2.593 HRD-in -77.84, -41.46 68.92, -13.37 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.74, 13.42 APE9-dihe-in -108.0, 146.11 APE8-dihe-in -55.87, 118.95 APE8-rot-na 334.41 APE67-dihe-in -77.03, -3.15 -66.33, -25.17 APE12-dist-na 14.723 APE11-dist-na 11.018 APE10-dist-na 8.04 APE9-dist-in 5.535 R675G None None XRAY 2.58 0.197 0.255 C 310 283 17 0 0 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5FLFD 465 763 822.0 No_ligand No_ligand Inactive DFGin 6.563 14.075 BLAminus -137.61, -174.47 56.6, 77.52 -99.56, 24.88 289.94, 80.48 -64.3, -28.41 in-in in 7.277 Saltbr-in 2.824 HRD-in -82.09, -46.03 69.99, -9.21 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.36, 26.56 APE9-dihe-in -112.27, 140.35 APE8-dihe-in -53.21, 117.11 APE8-rot-na 330.63 APE67-dihe-in -75.55, -3.28 -53.96, -35.33 APE12-dist-na 14.943 APE11-dist-na 10.506 APE10-dist-na 7.993 APE9-dist-in 5.598 R675G None None XRAY 2.58 0.197 0.255 D 310 290 9 0 0 0 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWIA 460 764 822.0 No_ligand No_ligand Inactive DFGin 5.19 13.287 BLAplus -105.16, 163.21 56.87, 28.19 -74.61, -16.94 54.32, 87.9 -104.05, 11.37 in-in in 7.964 Saltbr-in 2.691 HRD-in -73.3, -52.29 82.32, -10.23 in-out-out SNCioo out-out ActLoopNT-out 8.1 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.29, 144.76 APE9-dihe-in -100.4, 99.63 APE8-dihe-out -55.34, -23.98 APE8-rot-na 331.55 APE67-dihe-in -74.41, -9.61 -59.83, -21.73 APE12-dist-na 17.492 APE11-dist-na 19.033 APE10-dist-na 16.578 APE9-dist-out 11.232 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 A 317 305 0 0 0 0 [[478, 756]] 1.0 4rwi TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWIB 461 763 822.0 No_ligand No_ligand Inactive DFGin 5.141 13.154 BLAplus -106.54, 164.69 57.29, 29.78 -77.53, -18.65 57.49, 89.17 -101.92, 7.65 in-in in 7.879 Saltbr-in 2.87 HRD-in -73.64, -53.72 81.97, -10.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.37, 146.39 APE9-dihe-in -96.99, 106.58 APE8-dihe-out -51.08, -23.64 APE8-rot-na 329.78 APE67-dihe-in -74.22, -7.08 -61.58, -21.03 APE12-dist-na 999.0 APE11-dist-na 21.638 APE10-dist-na 19.316 APE9-dist-out 11.632 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 B 317 280 23 0 0 5 [[478, 756]] 1.0 4rwi TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
1FGKA 464 762 822.0 No_ligand No_ligand Inactive DFGin 5.04 13.153 BLAplus -117.08, 161.77 60.28, 24.85 -72.88, -22.06 56.54, 82.81 -106.67, 14.32 in-in in 7.832 Saltbr-in 3.378 HRD-in -62.23, -53.96 80.79, -13.7 in-out-out SNCioo out-out ActLoopNT-out 8.982 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.16, 160.27 APE9-dihe-in -100.02, 107.51 APE8-dihe-out -50.6, -26.19 APE8-rot-na 325.57 APE67-dihe-in -72.28, -4.51 -59.98, -18.19 APE12-dist-na 19.507 APE11-dist-na 20.666 APE10-dist-na 19.108 APE9-dist-out 11.795 None None None XRAY 2.0 0.213 0.261 A 310 278 21 0 0 0 [[478, 756]] 1.0 1fgk TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
1FGKB 461 761 822.0 No_ligand No_ligand Inactive DFGin 5.192 12.934 BLAplus -119.81, 158.37 63.11, 25.45 -77.92, -15.92 57.79, 81.67 -107.61, 13.08 in-in in 7.691 Saltbr-in 3.032 HRD-in -69.81, -40.78 70.38, -11.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.56, 167.66 APE9-dihe-in -110.12, 112.64 APE8-dihe-out -55.04, -21.46 APE8-rot-na 323.57 APE67-dihe-in -69.19, -4.96 -60.35, -22.4 APE12-dist-na 999.0 APE11-dist-na 20.964 APE10-dist-na 19.563 APE9-dist-out 11.572 C488A None None XRAY 2.0 0.213 0.261 B 310 272 29 0 0 9 [[478, 756]] 1.0 1fgk TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4UWYA 462 762 822.0 No_ligand No_ligand Inactive DFGin 5.291 12.863 BLAplus -108.05, 160.93 49.5, 43.38 -87.31, -20.81 54.11, 89.18 -97.03, 5.71 in-in in 7.508 Saltbr-in 2.443 HRD-in -75.4, -42.68 70.46, -5.54 in-out-out SNCioo out-out ActLoopNT-out 7.659 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.93, 150.1 APE9-dihe-in -108.91, 96.97 APE8-dihe-out -51.49, -30.02 APE8-rot-na 332.53 APE67-dihe-in -69.11, -13.52 -51.63, -33.68 APE12-dist-na 16.731 APE11-dist-na 19.192 APE10-dist-na 16.474 APE9-dist-out 11.016 None None None XRAY 2.305 0.214 0.267 A 310 296 5 0 0 0 [[478, 756]] 1.0 4uwy TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4UWYB 459 762 822.0 No_ligand No_ligand Inactive DFGin 5.113 12.787 BLAplus -107.94, 162.87 51.01, 42.84 -88.14, -19.95 53.77, 88.06 -94.96, 5.78 in-in in 7.418 Saltbr-in 2.548 HRD-in -75.22, -44.02 71.63, -5.56 in-out-out SNCioo out-out ActLoopNT-out 7.722 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.53 APE8-dihe-out -53.14, -29.69 APE8-rot-na 332.32 APE67-dihe-in -67.22, -11.8 -51.66, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.733 None None None XRAY 2.305 0.214 0.267 B 310 273 31 0 0 14 [[478, 756]] 1.0 4uwy TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3KY2A 458 764 822.0 No_ligand No_ligand Inactive DFGin 5.142 13.303 BLAplus -122.69, 172.32 46.54, 42.6 -95.25, -13.81 55.54, 83.43 -110.08, 21.37 in-in in 7.983 Saltbr-in 2.704 HRD-in -54.04, -52.31 78.54, -4.33 in-out-out SNCioo out-out ActLoopNT-out 7.905 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.74, 144.51 APE9-dihe-in -109.2, 106.89 APE8-dihe-out -56.11, -24.62 APE8-rot-na 329.61 APE67-dihe-in -74.45, -13.88 -60.05, -25.51 APE12-dist-na 17.026 APE11-dist-na 19.618 APE10-dist-na 16.611 APE9-dist-out 11.139 C488A,C584S None None XRAY 2.7 0.206 0.252 A 317 305 2 0 0 0 [[478, 756]] 1.0 3ky2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3KY2B 460 763 822.0 No_ligand No_ligand Inactive DFGin 5.306 13.131 BLAplus -120.14, 165.15 53.12, 37.21 -90.32, -21.71 57.04, 89.19 -96.69, 4.05 in-in in 7.75 Saltbr-in 2.873 HRD-in -63.32, -45.74 74.66, -3.4 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.35, 149.7 APE9-dihe-in -86.12, 120.09 APE8-dihe-out -58.71, -15.12 APE8-rot-na 326.3 APE67-dihe-in -64.29, -14.63 -68.37, -29.74 APE12-dist-na 19.93 APE11-dist-na 21.279 APE10-dist-na 19.838 APE9-dist-out 11.793 C488A,C584S None None XRAY 2.7 0.206 0.252 B 317 280 24 0 0 6 [[478, 756]] 1.0 3ky2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWLA 465 765 822.0 No_ligand No_ligand Inactive DFGin 5.26 13.19 BLAplus -120.07, 160.93 64.42, 29.27 -80.33, -20.1 51.65, 89.33 -96.98, 0.13 in-in in 7.774 Saltbr-in 2.904 HRD-in -75.31, -52.96 79.05, -10.93 in-out-out SNCioo out-out ActLoopNT-out 8.242 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.23, 163.46 APE9-dihe-in -103.38, 113.99 APE8-dihe-out -51.08, -26.28 APE8-rot-na 327.94 APE67-dihe-in -75.8, -7.21 -59.7, -19.52 APE12-dist-na 19.715 APE11-dist-na 21.18 APE10-dist-na 19.602 APE9-dist-out 11.603 C488A,C584S None None XRAY 2.193 0.209 0.256 A 317 282 19 0 0 3 [[478, 756]] 1.0 4rwl TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5FLFE 466 761 822.0 No_ligand No_ligand Inactive DFGin 5.857 13.333 BLAplus -107.08, 156.12 59.3, 89.04 -145.68, 9.21 46.94, 85.34 -107.07, -8.42 in-out in 7.681 Saltbr-out 4.122 HRD-in -76.44, -47.72 79.39, -32.07 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -134.53, 84.16 APE9-dihe-out 70.54, 76.98 APE8-dihe-out -73.71, -15.89 APE8-rot-na 29.38 APE67-dihe-in -66.59, -10.19 -60.2, -29.73 APE12-dist-na 999.0 APE11-dist-na 15.329 APE10-dist-na 19.628 APE9-dist-out 11.396 R675G None None XRAY 2.58 0.197 0.255 E 310 258 38 0 0 14 [[478, 756]] 1.0 5flf TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5AM7A 458 764 822.0 38O:1000 Type1 Inactive DFGin 5.322 13.404 BLAplus -119.96, 160.03 61.93, 31.32 -78.06, -16.68 51.95, 91.0 -102.88, 8.06 in-in in 7.784 Saltbr-in 2.821 HRD-in -72.13, -53.65 81.66, -13.87 in-out-out SNCioo out-out ActLoopNT-out 8.844 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.07, 161.69 APE9-dihe-in -97.7, 110.93 APE8-dihe-out -50.41, -28.65 APE8-rot-na 335.18 APE67-dihe-in -73.88, -5.16 -55.74, -23.35 APE12-dist-na 19.89 APE11-dist-na 21.192 APE10-dist-na 19.934 APE9-dist-out 11.887 V561M None None XRAY 1.957 0.201 0.254 A 310 294 13 0 0 0 [[478, 756]] 1.0 5am7 TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5AM7B 458 762 822.0 38O:1000 Type1 Inactive DFGin 5.351 13.056 BLAplus -118.51, 161.73 60.87, 31.35 -81.93, -17.68 51.44, 85.63 -98.47, 10.33 in-in in 7.879 Saltbr-in 3.092 HRD-in -70.81, -53.93 79.14, -12.6 in-out-out SNCioo out-out ActLoopNT-out 8.493 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.26, 167.43 APE9-dihe-in -92.91, 111.75 APE8-dihe-out -51.15, -27.96 APE8-rot-na 332.74 APE67-dihe-in -72.49, -4.42 -56.51, -22.72 APE12-dist-na 19.29 APE11-dist-na 21.059 APE10-dist-na 19.935 APE9-dist-out 11.772 V561M None None XRAY 1.957 0.201 0.254 B 310 287 18 0 0 5 [[478, 756]] 1.0 5am7 TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWKA 458 764 822.0 66T:60801 Type1 Inactive DFGin 5.334 13.448 BLAplus -119.61, 171.78 43.5, 42.06 -91.27, -13.97 55.41, 85.99 -97.85, 1.35 in-in in 8.3 Saltbr-in 2.858 HRD-in -72.97, -43.98 66.64, 7.94 in-out-out SNCioo out-out ActLoopNT-out 7.612 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -132.9, 130.16 APE9-dihe-in -81.93, 117.68 APE8-dihe-out -73.74, -2.4 APE8-rot-na 340.19 APE67-dihe-in -78.12, -6.2 -84.98, -15.3 APE12-dist-na 17.009 APE11-dist-na 18.951 APE10-dist-na 16.709 APE9-dist-out 11.004 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 A 317 307 0 0 0 0 [[478, 756]] 1.0 4rwk TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4ZSAA 464 765 822.0 4UT:801 Type1 Inactive DFGin 5.236 13.358 BLAplus -116.62, 164.17 62.61, 38.9 -97.55, -0.8 57.69, 84.31 -93.9, -12.07 in-in in 7.727 Saltbr-in 3.074 HRD-in -75.4, -51.03 78.41, -18.38 in-out-out SNCioo out-out ActLoopNT-out 7.801 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.19, 166.07 APE9-dihe-in -106.61, 111.7 APE8-dihe-out -53.66, -24.02 APE8-rot-na 328.26 APE67-dihe-in -75.2, -3.02 -58.56, -21.55 APE12-dist-na 20.997 APE11-dist-na 22.32 APE10-dist-na 20.795 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.0 0.206 0.254 A 308 290 12 0 0 0 [[478, 756]] 1.0 4zsa TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4ZSAB 462 761 822.0 4UT:801 Type1 Inactive DFGin 5.378 12.914 BLAplus -118.54, 160.55 64.46, 37.46 -95.07, -9.43 54.72, 89.6 -73.6, -19.27 in-in in 7.641 Saltbr-in 3.163 HRD-in -75.52, -45.77 74.73, -25.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.36, 172.16 APE9-dihe-in -104.52, 114.27 APE8-dihe-out -53.39, -26.0 APE8-rot-na 330.81 APE67-dihe-in -73.62, -3.9 -59.13, -21.5 APE12-dist-na 20.725 APE11-dist-na 22.162 APE10-dist-na 20.859 APE9-dist-out 11.525 C488A,C584S None None XRAY 2.0 0.206 0.254 B 308 282 18 0 0 6 [[478, 756]] 1.0 4zsa TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5Z0SA 464 762 822.0 960:801 Type1 Inactive DFGin 5.126 13.601 BLAplus -107.75, 154.51 67.56, 21.06 -67.0, -16.05 58.84, 83.24 -104.7, 10.76 in-in in 8.094 Saltbr-in 2.743 HRD-in -68.85, -52.46 79.64, -4.73 in-out-out SNCioo out-out ActLoopNT-out 8.709 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -91.28, 165.51 APE9-dihe-in -109.21, 113.36 APE8-dihe-out -56.28, -24.44 APE8-rot-na 329.92 APE67-dihe-in -71.21, -1.87 -54.7, -23.75 APE12-dist-na 19.955 APE11-dist-na 21.515 APE10-dist-na 19.768 APE9-dist-out 11.976 C488A,C584S None None XRAY 2.45 0.227 0.275 A 308 285 14 0 0 0 [[478, 756]] 1.0 5z0s TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5Z0SB 464 761 822.0 960:801 Type1 Inactive DFGin 5.197 13.43 BLAplus -118.1, 161.06 54.97, 27.99 -69.34, -31.76 53.53, 89.4 -87.91, 8.99 in-in in 7.946 Saltbr-in 2.979 HRD-in -70.36, -53.32 74.41, -8.98 in-out-out SNCioo out-out ActLoopNT-out 8.874 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.22, 166.31 APE9-dihe-in -107.5, 114.63 APE8-dihe-out -57.82, -27.73 APE8-rot-na 335.53 APE67-dihe-in -71.06, -7.47 -49.72, -27.2 APE12-dist-na 19.592 APE11-dist-na 21.39 APE10-dist-na 19.783 APE9-dist-out 11.761 C488A,C584S None None XRAY 2.45 0.227 0.275 B 308 281 17 0 0 1 [[478, 756]] 1.0 5z0s TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6ITJA 464 765 822.0 AXU:801 Type1 Inactive DFGin 5.03 13.791 BLAplus -109.33, 156.39 67.34, 25.69 -70.89, -16.74 55.89, 87.5 -104.45, 10.23 in-in in 8.034 Saltbr-in 2.757 HRD-in -71.81, -52.98 81.18, -14.83 in-out-out SNCioo out-out ActLoopNT-out 8.717 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.06, 160.2 APE9-dihe-in -100.03, 111.11 APE8-dihe-out -53.01, -25.62 APE8-rot-na 330.27 APE67-dihe-in -75.62, -3.59 -58.81, -16.58 APE12-dist-na 19.46 APE11-dist-na 21.02 APE10-dist-na 19.465 APE9-dist-out 11.773 C488A,C584S None None XRAY 1.994 0.201 0.244 A 308 290 12 0 0 0 [[478, 756]] 1.0 6itj TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6ITJB 459 761 822.0 AXU:801 Type1 Inactive DFGin 5.279 13.661 BLAplus -115.06, 158.21 61.95, 30.4 -73.56, -20.55 53.39, 86.78 -101.45, 8.81 in-in in 7.858 Saltbr-in 2.784 HRD-in -74.1, -50.66 79.66, -17.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.82, 164.92 APE9-dihe-in -97.18, 112.3 APE8-dihe-out -56.27, -24.59 APE8-rot-na 332.48 APE67-dihe-in -69.44, -5.6 -58.71, -22.22 APE12-dist-na 19.468 APE11-dist-na 21.022 APE10-dist-na 19.807 APE9-dist-out 11.652 C488A,C584S None None XRAY 1.994 0.201 0.244 B 308 293 10 0 0 5 [[478, 756]] 1.0 6itj TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
9CD5A 465 764 822.0 A1AV2:903 Type1 Inactive DFGin 5.109 13.041 BLAplus -119.69, 171.16 42.37, 48.64 -93.51, -18.78 55.6, 81.67 -108.27, 19.83 in-in in 7.642 Saltbr-in 3.4 HRD-in -70.51, -58.43 92.5, -15.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -123.63, 147.65 APE9-dihe-in -93.38, 113.67 APE8-dihe-out -55.42, -20.8 APE8-rot-na 334.26 APE67-dihe-in -78.47, -7.11 -58.87, -20.29 APE12-dist-na 21.398 APE11-dist-na 21.238 APE10-dist-na 19.52 APE9-dist-out 11.608 C488A,C584S None None XRAY 2.939 0.215 0.263 A 308 281 19 0 0 6 [[478, 756]] 1.0 9cd5 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
9CD5B 460 764 822.0 A1AV2:902 Type1 Inactive DFGin 5.112 12.776 BLAplus -119.68, 169.96 44.78, 47.92 -93.2, -18.16 54.47, 80.79 -103.83, 15.64 in-in in 7.59 Saltbr-in 3.242 HRD-in -70.44, -57.93 92.25, -15.3 in-out-out SNCioo out-out ActLoopNT-out 7.979 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.57, 148.55 APE9-dihe-in -93.36, 113.84 APE8-dihe-out -53.62, -20.73 APE8-rot-na 332.43 APE67-dihe-in -77.99, -7.05 -59.24, -19.94 APE12-dist-na 21.01 APE11-dist-na 20.993 APE10-dist-na 19.181 APE9-dist-out 11.584 C488A,C584S None None XRAY 2.939 0.215 0.263 B 308 289 16 0 0 2 [[478, 756]] 1.0 9cd5 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4F63A 464 762 822.0 0S7:801 Type1 Inactive DFGin 5.272 13.227 BLAplus -123.63, 158.75 70.08, 13.43 -68.79, -20.53 59.97, 88.79 -95.8, 8.85 in-in in 7.524 Saltbr-in 3.232 HRD-in -74.6, -50.94 76.01, -22.74 in-out-out SNCioo out-out ActLoopNT-out 8.974 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -83.88, 159.94 APE9-dihe-in -104.27, 121.64 APE8-dihe-out -54.29, -35.97 APE8-rot-na 333.58 APE67-dihe-in -71.9, -7.89 -48.05, -24.06 APE12-dist-na 19.824 APE11-dist-na 21.294 APE10-dist-na 19.49 APE9-dist-out 11.802 C488A,C584S None None XRAY 2.55 0.232 0.287 A 309 278 21 0 0 0 [[478, 756]] 1.0 4f63 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4F63B 461 761 822.0 0S7:801 Type1 Inactive DFGin 5.107 12.59 BLAplus -103.1, 171.09 57.7, 19.47 -72.81, -17.05 60.59, 83.16 -102.04, 8.53 in-none in 7.731 Saltbr-none 999.0 HRD-in -67.88, -51.25 73.72, -23.66 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.49, 174.14 APE9-dihe-in -102.48, 111.01 APE8-dihe-out -53.24, -29.21 APE8-rot-na 329.82 APE67-dihe-in -68.76, -1.69 -49.63, -27.49 APE12-dist-na 999.0 APE11-dist-na 20.78 APE10-dist-na 19.771 APE9-dist-out 11.499 C488A,C584S None None XRAY 2.55 0.232 0.287 B 309 271 30 0 0 9 [[478, 756]] 1.0 4f63 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4F64A 464 762 822.0 0S8:801 Type1 Inactive DFGin 5.183 13.118 BLAplus -126.63, 159.8 67.66, 19.43 -73.38, -15.37 61.14, 82.05 -112.05, 14.31 in-in in 7.833 Saltbr-in 2.657 HRD-in -75.01, -53.26 79.37, -13.8 in-out-out SNCioo out-out ActLoopNT-out 8.889 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.36, 162.32 APE9-dihe-in -110.59, 112.62 APE8-dihe-out -54.21, -21.82 APE8-rot-na 334.94 APE67-dihe-in -73.68, -4.51 -58.01, -22.74 APE12-dist-na 19.925 APE11-dist-na 21.624 APE10-dist-na 19.607 APE9-dist-out 11.74 C488A,C584S None None XRAY 2.05 0.217 0.269 A 309 278 21 0 0 0 [[478, 756]] 1.0 4f64 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4F64B 461 761 822.0 0S8:801 Type1 Inactive DFGin 5.167 12.905 BLAplus -128.73, 164.19 64.4, 29.6 -84.21, -15.05 59.33, 82.94 -106.3, 1.28 in-in in 7.894 Saltbr-in 2.864 HRD-in -73.33, -50.22 71.98, 0.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.2, 170.72 APE9-dihe-in -106.18, 108.15 APE8-dihe-out -52.36, -27.43 APE8-rot-na 328.0 APE67-dihe-in -80.92, -6.4 -55.61, -16.72 APE12-dist-na 999.0 APE11-dist-na 20.995 APE10-dist-na 19.853 APE9-dist-out 11.556 C488A,C584S None None XRAY 2.05 0.217 0.269 B 309 272 29 0 0 9 [[478, 756]] 1.0 4f64 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4NKAA 464 765 822.0 2K7:805 Type1 Inactive DFGin 5.46 12.83 BLAplus -109.75, 172.82 48.9, 35.6 -81.04, -25.72 46.07, 87.87 -114.73, 999.0 in-none in 7.756 Saltbr-none 999.0 HRD-in -68.09, -53.27 80.47, -22.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.83, 157.85 APE9-dihe-in -101.57, 110.94 APE8-dihe-out -54.92, -24.59 APE8-rot-na 334.91 APE67-dihe-in -67.94, -8.42 -53.61, -27.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.57 C488A,C584S None None XRAY 2.19 0.2 0.228 A 309 279 23 0 0 7 [[478, 756]] 1.0 4nka TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4NKSA 465 762 822.0 2M2:801 Type1 Inactive DFGin 5.63 13.809 BLAplus -128.87, 161.68 65.74, 29.25 -87.1, -15.4 56.23, 91.24 -92.95, -7.65 in-in in 7.896 Saltbr-in 3.034 HRD-in -61.09, -57.02 76.92, -17.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.5, 152.38 APE9-dihe-in -96.93, 124.37 APE8-dihe-out -60.38, -26.39 APE8-rot-na 339.01 APE67-dihe-in -76.01, -5.61 -56.44, -21.34 APE12-dist-na 20.012 APE11-dist-na 21.72 APE10-dist-na 19.688 APE9-dist-out 11.709 C488A,C584S None None XRAY 2.5 0.223 0.278 A 309 265 33 0 0 6 [[478, 756]] 1.0 4nks TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4NKSB 461 761 822.0 2M2:801 Type1 Inactive DFGin 5.47 13.082 BLAplus -121.26, 176.2 65.04, 19.79 -85.17, -9.87 56.43, 80.08 -103.8, -4.05 in-in in 7.809 Saltbr-in 3.228 HRD-in -66.41, -53.36 81.34, -22.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.88, 166.85 APE9-dihe-in -99.02, 113.91 APE8-dihe-out -58.98, -23.63 APE8-rot-na 332.76 APE67-dihe-in -64.8, 1.58 -54.87, -32.1 APE12-dist-na 999.0 APE11-dist-na 20.725 APE10-dist-na 19.536 APE9-dist-out 11.727 C488A,C584S None None XRAY 2.5 0.223 0.278 B 309 271 30 0 0 9 [[478, 756]] 1.0 4nks TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4UWBA 464 765 822.0 JVT:1769 Type1 Inactive DFGin 5.316 13.299 BLAplus -113.09, 161.83 71.69, 23.97 -88.05, -18.23 56.26, 82.28 -95.96, 11.67 in-in in 7.873 Saltbr-in 2.725 HRD-in -67.29, -55.31 79.69, -18.23 in-out-out SNCioo out-out ActLoopNT-out 8.961 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 154.4 APE9-dihe-in -93.53, 118.15 APE8-dihe-out -56.85, -29.21 APE8-rot-na 332.74 APE67-dihe-in -81.26, -7.02 -49.23, -21.08 APE12-dist-na 19.692 APE11-dist-na 21.382 APE10-dist-na 19.606 APE9-dist-out 11.781 C488A,C584S None None XRAY 2.31 0.231 0.272 A 309 299 3 0 0 1 [[478, 756]] 1.0 4uwb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4UWBB 459 765 822.0 JVT:1768 Type1 Inactive DFGin 5.437 13.03 BLAplus -114.82, 162.53 65.13, 21.85 -74.05, -17.91 55.13, 90.89 -100.48, 4.93 in-in in 7.888 Saltbr-in 2.708 HRD-in -76.21, -52.64 84.1, -25.36 in-out-out SNCioo out-out ActLoopNT-out 7.933 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.09, 162.16 APE9-dihe-in -103.08, 113.2 APE8-dihe-out -55.06, -17.49 APE8-rot-na 323.82 APE67-dihe-in -71.23, -5.74 -60.29, -25.5 APE12-dist-na 20.005 APE11-dist-na 21.388 APE10-dist-na 19.897 APE9-dist-out 11.597 C488A,C584S None None XRAY 2.31 0.231 0.272 B 309 299 8 0 0 3 [[478, 756]] 1.0 4uwb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4UWCA 465 765 822.0 4Y0:1773 Type1 Inactive DFGin 5.185 13.218 BLAplus -114.28, 167.51 64.08, 17.08 -73.37, -20.76 56.56, 86.09 -95.43, 0.2 in-in in 7.666 Saltbr-in 2.769 HRD-in -68.21, -55.41 81.81, -19.33 in-out-out SNCioo out-out ActLoopNT-out 8.009 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.15, 154.48 APE9-dihe-in -99.31, 111.29 APE8-dihe-out -53.23, -22.86 APE8-rot-na 338.31 APE67-dihe-in -68.82, -8.72 -56.37, -24.16 APE12-dist-na 20.301 APE11-dist-na 21.198 APE10-dist-na 19.379 APE9-dist-out 11.757 C488A,C584S None None XRAY 1.96 0.179 0.206 A 309 301 0 0 0 0 [[478, 756]] 1.0 4uwc TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4UWCB 459 764 822.0 4Y0:1770 Type1 Inactive DFGin 5.22 13.022 BLAplus -114.0, 163.28 67.1, 18.57 -73.54, -21.45 56.42, 85.19 -95.52, -0.76 in-in in 7.59 Saltbr-in 2.92 HRD-in -68.93, -54.08 82.79, -14.74 in-out-out SNCioo out-out ActLoopNT-out 8.343 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.38, 156.7 APE9-dihe-in -100.76, 111.03 APE8-dihe-out -54.68, -24.33 APE8-rot-na 334.31 APE67-dihe-in -64.61, -11.0 -54.66, -28.32 APE12-dist-na 20.088 APE11-dist-na 21.147 APE10-dist-na 19.481 APE9-dist-out 11.733 C488A,C584S None None XRAY 1.96 0.179 0.206 B 309 301 5 0 0 0 [[478, 756]] 1.0 4uwc TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5O49A 464 764 822.0 9K5:801 Type1 Inactive DFGin 5.24 13.638 BLAplus -124.98, 161.58 68.85, 20.17 -74.75, -11.05 61.69, 77.84 -110.93, 4.69 in-out in 8.125 Saltbr-out 5.546 HRD-in -64.73, -48.02 76.28, -6.18 out-out-out SNCooo out-out ActLoopNT-out 8.782 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.25, 168.76 APE9-dihe-in -119.19, 119.01 APE8-dihe-out -64.8, -20.97 APE8-rot-na 343.93 APE67-dihe-in -73.72, -10.74 -55.47, -23.05 APE12-dist-na 19.565 APE11-dist-na 21.14 APE10-dist-na 19.5 APE9-dist-out 11.833 C488A,C584S None None XRAY 1.91 0.2 0.22 A 309 289 12 0 0 0 [[478, 756]] 1.0 5o49 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5O49B 460 765 822.0 9K5:801 Type1 Inactive DFGin 5.619 12.929 BLAplus -126.58, 172.58 67.38, 24.13 -84.06, -18.33 50.82, 87.05 -104.51, 13.86 in-out in 7.638 Saltbr-out 4.5 HRD-in -61.81, -47.66 75.62, -5.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.43, 163.49 APE9-dihe-in -105.31, 114.78 APE8-dihe-out -56.47, -25.97 APE8-rot-na 333.8 APE67-dihe-in -70.86, -8.05 -56.14, -23.8 APE12-dist-na 19.012 APE11-dist-na 20.412 APE10-dist-na 18.787 APE9-dist-out 11.723 C488A,C584S None None XRAY 1.91 0.2 0.22 B 309 286 20 0 0 5 [[478, 756]] 1.0 5o49 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5O4AA 464 764 822.0 9K8:804 Type1 Inactive DFGin 5.412 13.545 BLAplus -122.09, 166.75 52.86, 39.44 -89.66, -24.51 52.16, 85.77 -93.11, 3.02 in-out in 7.921 Saltbr-out 5.707 HRD-in -69.28, -47.39 73.72, -11.63 out-out-out SNCooo out-out ActLoopNT-out 8.755 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.02, 156.72 APE9-dihe-in -102.28, 120.59 APE8-dihe-out -56.89, -30.5 APE8-rot-na 333.66 APE67-dihe-in -72.75, -8.94 -55.59, -20.78 APE12-dist-na 20.084 APE11-dist-na 21.459 APE10-dist-na 19.653 APE9-dist-out 11.899 None None None XRAY 2.01 0.217 0.225 A 309 290 11 0 0 0 [[478, 756]] 1.0 5o4a TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5O4AB 460 763 822.0 9K8:802 Type1 Inactive DFGin 5.521 13.094 BLAplus -119.73, 164.81 56.03, 47.68 -94.68, -27.26 47.68, 87.08 -89.69, 6.98 in-out in 7.734 Saltbr-out 4.109 HRD-in -64.38, -47.45 77.25, -12.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.24, 154.27 APE9-dihe-in -101.59, 121.81 APE8-dihe-out -57.48, -31.39 APE8-rot-na 330.82 APE67-dihe-in -66.62, 0.37 -53.02, -29.01 APE12-dist-na 20.018 APE11-dist-na 21.049 APE10-dist-na 19.102 APE9-dist-out 11.703 None None None XRAY 2.01 0.217 0.225 B 309 291 13 0 0 5 [[478, 756]] 1.0 5o4a TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7OZBAAA 464 765 822.0 47I:801 Type1 Inactive DFGin 5.165 13.226 BLAplus -113.5, 164.02 64.24, 28.44 -81.1, -17.3 55.31, 86.35 -99.81, -4.02 in-in in 7.678 Saltbr-in 3.035 HRD-in -68.22, -55.33 81.75, -15.47 in-out-out SNCioo out-out ActLoopNT-out 8.629 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.53, 159.74 APE9-dihe-in -101.43, 112.26 APE8-dihe-out -54.35, -25.93 APE8-rot-na 332.55 APE67-dihe-in -70.65, -7.52 -55.15, -25.11 APE12-dist-na 19.292 APE11-dist-na 20.745 APE10-dist-na 19.195 APE9-dist-out 11.664 C488A,C584S None None XRAY 1.71 0.211 0.244 AAA 309 288 14 0 0 0 [[478, 756]] 1.0 7ozb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7OZBBBB 460 764 822.0 47I:801 Type1 Inactive DFGin 5.22 12.853 BLAplus -116.55, 158.6 67.07, 25.64 -79.35, -20.91 57.12, 84.44 -89.98, -6.37 in-in in 7.631 Saltbr-in 2.983 HRD-in -68.5, -59.33 86.86, -18.0 in-out-out SNCioo out-out ActLoopNT-out 8.193 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.69, 159.38 APE9-dihe-in -99.92, 110.92 APE8-dihe-out -56.91, -22.49 APE8-rot-na 333.27 APE67-dihe-in -69.35, -9.22 -56.3, -24.07 APE12-dist-na 19.557 APE11-dist-na 20.901 APE10-dist-na 19.32 APE9-dist-out 11.557 C488A,C584S None None XRAY 1.71 0.211 0.244 BBB 309 291 14 0 0 0 [[478, 756]] 1.0 7ozb TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7OZDAAA 464 765 822.0 42I:801 Type1 Inactive DFGin 5.189 13.322 BLAplus -116.42, 163.08 62.72, 27.25 -80.95, -15.5 58.36, 83.15 -93.3, -6.95 in-in in 7.699 Saltbr-in 2.885 HRD-in -70.31, -57.17 82.73, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.1, 157.43 APE9-dihe-in -99.3, 111.88 APE8-dihe-out -57.0, -23.76 APE8-rot-na 335.77 APE67-dihe-in -73.24, -6.2 -56.45, -22.92 APE12-dist-na 20.067 APE11-dist-na 21.455 APE10-dist-na 19.818 APE9-dist-out 11.756 C488A,C584S None None XRAY 1.82 0.201 0.241 AAA 309 282 20 0 0 6 [[478, 756]] 1.0 7ozd TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7OZDBBB 460 763 822.0 42I:801 Type1 Inactive DFGin 5.218 12.867 BLAplus -120.15, 162.48 66.77, 26.73 -83.0, -17.85 57.88, 82.23 -92.89, -7.69 in-in in 7.547 Saltbr-in 2.97 HRD-in -73.06, -57.3 87.17, -16.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -111.05, 157.78 APE9-dihe-in -98.55, 112.28 APE8-dihe-out -56.64, -24.18 APE8-rot-na 331.82 APE67-dihe-in -72.02, -11.22 -53.55, -23.65 APE12-dist-na 19.616 APE11-dist-na 20.938 APE10-dist-na 19.366 APE9-dist-out 11.599 C488A,C584S None None XRAY 1.82 0.201 0.241 BBB 309 285 19 0 0 5 [[478, 756]] 1.0 7ozd TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7OZFAAA 465 765 822.0 466:801 Type1 Inactive DFGin 5.295 13.468 BLAplus -117.68, 161.62 66.46, 36.41 -95.38, -7.29 57.95, 82.09 -95.91, -11.26 in-in in 7.802 Saltbr-in 3.034 HRD-in -74.16, -54.6 82.1, -14.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 162.73 APE9-dihe-in -101.57, 112.99 APE8-dihe-out -53.92, -25.84 APE8-rot-na 335.55 APE67-dihe-in -73.42, -8.15 -56.91, -22.71 APE12-dist-na 20.334 APE11-dist-na 21.678 APE10-dist-na 20.2 APE9-dist-out 11.727 None None None XRAY 1.82 0.206 0.242 AAA 309 288 13 0 0 5 [[478, 756]] 1.0 7ozf TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7OZFBBB 460 763 822.0 466:801 Type1 Inactive DFGin 5.253 13.023 BLAplus -116.0, 158.26 69.37, 33.48 -90.88, -17.29 57.42, 83.97 -77.99, -12.47 in-in in 7.643 Saltbr-in 2.966 HRD-in -73.91, -57.88 84.04, -15.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.71, 160.57 APE9-dihe-in -98.6, 110.79 APE8-dihe-out -55.8, -24.65 APE8-rot-na 332.84 APE67-dihe-in -74.09, -8.17 -55.72, -20.54 APE12-dist-na 20.458 APE11-dist-na 21.859 APE10-dist-na 20.178 APE9-dist-out 11.652 None None None XRAY 1.82 0.206 0.242 BBB 309 282 22 0 0 5 [[478, 756]] 1.0 7ozf TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
1AGWA 464 762 822.0 SU2:1001 Type1 Inactive DFGin 5.274 13.389 BLAplus -121.22, 164.09 62.54, 22.82 -75.41, -18.74 57.89, 80.74 -105.07, 9.46 in-out in 7.71 Saltbr-out 3.845 HRD-in -69.09, -52.68 78.93, -10.47 out-out-out SNCooo out-out ActLoopNT-out 9.072 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.44, 164.07 APE9-dihe-in -103.49, 105.01 APE8-dihe-out -48.23, -28.22 APE8-rot-na 326.86 APE67-dihe-in -79.1, -0.7 -60.74, -14.06 APE12-dist-na 19.71 APE11-dist-na 20.873 APE10-dist-na 19.257 APE9-dist-out 11.903 None None None XRAY 2.4 0.194 0.28 A 310 278 21 0 0 0 [[478, 756]] 1.0 1agw TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
1AGWB 461 761 822.0 SU2:1000 Type1 Inactive DFGin 5.105 12.927 BLAplus -118.48, 160.09 61.53, 23.36 -75.62, -9.51 55.77, 89.71 -113.95, 12.53 in-in in 7.774 Saltbr-in 2.974 HRD-in -65.85, -35.14 62.11, -1.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.88, 159.91 APE9-dihe-in -102.85, 114.8 APE8-dihe-out -54.83, -28.49 APE8-rot-na 327.14 APE67-dihe-in -71.12, -9.61 -53.83, -20.83 APE12-dist-na 999.0 APE11-dist-na 21.087 APE10-dist-na 19.559 APE9-dist-out 11.794 C488A None None XRAY 2.4 0.194 0.28 B 310 272 29 0 0 9 [[478, 756]] 1.0 1agw TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
1FGIA 464 762 822.0 SU1:1001 Type1 Inactive DFGin 5.245 13.051 BLAplus -118.43, 166.43 66.52, 8.73 -64.13, -34.61 60.57, 85.04 -94.1, 14.31 in-out in 7.81 Saltbr-out 4.394 HRD-in -65.25, -56.3 86.33, -6.46 out-out-out SNCooo out-out ActLoopNT-out 9.019 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.01, 168.11 APE9-dihe-in -109.23, 108.22 APE8-dihe-out -49.03, -28.53 APE8-rot-na 326.13 APE67-dihe-in -78.81, -8.46 -60.3, -12.78 APE12-dist-na 19.401 APE11-dist-na 20.922 APE10-dist-na 19.213 APE9-dist-out 11.74 C488A None None XRAY 2.5 0.19 0.27 A 310 283 16 0 0 0 [[478, 756]] 1.0 1fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
1FGIB 461 761 822.0 SU1:1000 Type1 Inactive DFGin 5.085 12.887 BLAplus -129.12, 161.76 68.96, 4.34 -61.61, -28.72 62.68, 83.75 -98.14, 18.47 in-in in 7.977 Saltbr-in 3.237 HRD-in -67.23, -42.86 65.67, 6.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.03, 163.6 APE9-dihe-in -107.58, 116.43 APE8-dihe-out -54.66, -25.86 APE8-rot-na 323.83 APE67-dihe-in -66.67, -9.45 -56.63, -25.45 APE12-dist-na 999.0 APE11-dist-na 21.117 APE10-dist-na 19.557 APE9-dist-out 11.785 C488A None None XRAY 2.5 0.19 0.27 B 310 272 29 0 0 9 [[478, 756]] 1.0 1fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5AM6A 458 765 822.0 38O:61766 Type1 Inactive DFGin 5.201 13.27 BLAplus -112.58, 159.52 61.38, 32.49 -78.96, -18.15 54.05, 84.03 -102.14, 12.3 in-in in 7.715 Saltbr-in 3.252 HRD-in -73.83, -55.77 84.43, -16.37 in-out-out SNCioo out-out ActLoopNT-out 8.728 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.68, 158.35 APE9-dihe-in -101.09, 116.06 APE8-dihe-out -55.18, -24.78 APE8-rot-na 339.12 APE67-dihe-in -70.49, -7.18 -57.16, -24.6 APE12-dist-na 19.76 APE11-dist-na 21.181 APE10-dist-na 19.861 APE9-dist-out 11.765 None None None XRAY 1.96 0.216 0.252 A 310 294 14 0 0 0 [[478, 756]] 1.0 5am6 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5AM6B 458 762 822.0 38O:61763 Type1 Inactive DFGin 5.279 13.04 BLAplus -109.26, 159.81 58.35, 42.16 -91.18, -11.81 51.78, 82.49 -107.62, 15.27 in-in in 7.645 Saltbr-in 3.495 HRD-in -73.63, -54.03 80.88, -21.94 in-out-out SNCioo out-out ActLoopNT-out 8.615 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.73, 157.38 APE9-dihe-in -92.88, 109.99 APE8-dihe-out -51.36, -29.92 APE8-rot-na 334.27 APE67-dihe-in -70.82, -6.38 -56.34, -19.57 APE12-dist-na 999.0 APE11-dist-na 21.131 APE10-dist-na 19.744 APE9-dist-out 11.636 None None None XRAY 1.96 0.216 0.252 B 310 280 25 0 0 13 [[478, 756]] 1.0 5am6 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5UQ0A 464 765 822.0 WP1:801 Type1 Inactive DFGin 5.223 13.345 BLAplus -129.51, 154.04 71.7, 22.04 -75.61, 2.54 58.4, 85.52 -125.18, 1.34 in-none in 7.844 Saltbr-none 999.0 HRD-in -67.62, -52.6 81.66, -15.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 93.59 APE8-dihe-out -63.72, -18.01 APE8-rot-na 26.7 APE67-dihe-in -66.9, -7.24 -49.77, -36.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.247 C488A,C584S None None XRAY 2.3 0.237 0.294 A 311 266 36 0 0 17 [[478, 756]] 1.0 5uq0 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5UQ0B 463 762 822.0 WP1:801 Type1 Inactive DFGin 5.252 13.118 BLAplus -135.89, 161.84 57.67, 28.98 -76.93, -27.79 58.9, 86.78 -79.34, -7.22 in-in in 8.18 Saltbr-in 2.638 HRD-in -67.2, -48.58 76.55, -0.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -106.5 APE8-dihe-out -49.01, -32.28 APE8-rot-na 23.14 APE67-dihe-in -80.37, 4.41 -44.32, -39.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.069 C488A,C584S None None XRAY 2.3 0.237 0.294 B 311 256 44 0 0 17 [[478, 756]] 1.0 5uq0 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3JS2A 464 765 822.0 VM1:801 Type1 Inactive DFGin 5.153 13.303 BLAplus -121.66, 167.26 60.21, 27.33 -82.6, -17.8 54.2, 84.02 -103.88, 10.59 in-in in 7.724 Saltbr-in 3.051 HRD-in -72.72, -56.56 85.97, -17.24 in-out-out SNCioo out-out ActLoopNT-out 7.969 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.37, 154.98 APE9-dihe-in -92.36, 117.27 APE8-dihe-out -54.75, -26.7 APE8-rot-na 329.63 APE67-dihe-in -71.32, -6.64 -59.57, -19.47 APE12-dist-na 19.16 APE11-dist-na 20.783 APE10-dist-na 19.319 APE9-dist-out 11.814 C488A,C584S None None XRAY 2.2 0.216 0.259 A 317 295 7 0 0 0 [[478, 756]] 1.0 3js2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3JS2B 459 762 822.0 VM1:801 Type1 Inactive DFGin 5.166 12.915 BLAplus -117.79, 168.89 57.38, 26.57 -81.81, -21.58 58.31, 81.41 -101.15, 4.46 in-in in 7.415 Saltbr-in 2.898 HRD-in -70.61, -55.45 85.21, -19.22 in-out-out SNCioo out-out ActLoopNT-out 8.388 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.77, 164.88 APE9-dihe-in -101.88, 109.77 APE8-dihe-out -47.5, -33.8 APE8-rot-na 323.58 APE67-dihe-in -71.37, -10.85 -58.97, -16.94 APE12-dist-na 19.428 APE11-dist-na 20.934 APE10-dist-na 19.561 APE9-dist-out 11.776 C488A,C584S None None XRAY 2.2 0.216 0.259 B 317 291 13 0 0 0 [[478, 756]] 1.0 3js2 TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3GQLC 463 766 822.0 GQL:1 Type1 Inactive DFGin 5.708 13.027 BLAplus -123.78, 172.03 54.97, 32.17 -87.82, -13.88 53.39, 70.63 -108.09, 38.81 in-in in 7.805 Saltbr-in 2.616 HRD-in -59.51, -40.97 72.56, -22.95 in-out-none SNCion out-none ActLoopNT-out 8.758 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.55 APE8-rot-na 32.95 APE67-dihe-in -61.65, -18.42 -80.52, -27.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 C 326 275 29 0 0 16 [[478, 756]] 1.0 3gql TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8JMZA 460 765 822.0 UKI:60801 Type1 Inactive DFGin 5.159 13.289 BLAplus -113.58, 162.96 62.0, 28.58 -83.36, -13.84 56.58, 89.17 -102.65, 12.75 in-in in 7.859 Saltbr-in 2.835 HRD-in -72.3, -51.47 78.17, -4.24 in-out-out SNCioo out-out ActLoopNT-out 7.981 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.22, 148.56 APE9-dihe-in -107.32, 99.52 APE8-dihe-out -56.46, -18.86 APE8-rot-na 328.17 APE67-dihe-in -74.96, -9.03 -56.04, -27.86 APE12-dist-na 16.425 APE11-dist-na 18.997 APE10-dist-na 16.223 APE9-dist-out 11.021 C584S None None XRAY 1.988 0.166 0.205 A 310 306 0 0 0 0 [[478, 756]] 1.0 8jmz TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8JMZB 458 763 822.0 UKI:60801 Type1 Inactive DFGin 5.259 13.007 BLAplus -114.88, 158.62 61.68, 33.22 -84.25, -18.02 53.38, 88.43 -92.93, -0.34 in-in in 7.767 Saltbr-in 2.924 HRD-in -72.45, -50.78 74.31, -4.23 in-out-out SNCioo out-out ActLoopNT-out 8.354 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.73, 168.34 APE9-dihe-in -103.17, 113.28 APE8-dihe-out -51.14, -25.22 APE8-rot-na 328.21 APE67-dihe-in -74.28, -2.47 -57.8, -24.89 APE12-dist-na 20.439 APE11-dist-na 21.401 APE10-dist-na 20.065 APE9-dist-out 11.501 C584S None None XRAY 1.988 0.166 0.205 B 310 290 16 0 0 3 [[478, 756]] 1.0 8jmz TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
9UHCA 458 764 822.0 A1EPE:60801 Type1 Inactive DFGin 5.089 13.566 BLAplus -99.26, 163.63 67.92, 18.69 -73.13, -23.6 54.69, 89.65 -94.23, 7.24 in-in in 8.58 Saltbr-in 2.837 HRD-in -81.76, -52.28 81.48, -12.21 in-out-out SNCioo out-out ActLoopNT-out 7.689 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.01, 148.62 APE9-dihe-in -107.23, 98.65 APE8-dihe-out -61.69, -18.58 APE8-rot-na 332.39 APE67-dihe-in -73.38, -10.07 -53.51, -28.36 APE12-dist-na 17.33 APE11-dist-na 19.828 APE10-dist-na 16.888 APE9-dist-out 11.084 None None None XRAY 1.88 0.173 0.205 A 310 307 0 0 0 0 [[478, 756]] 1.0 9uhc TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
9UHCB 458 763 822.0 A1EPE:60801 Type1 Inactive DFGin 5.28 12.91 BLAplus -104.01, 159.23 73.73, 21.61 -75.73, -25.49 53.38, 87.57 -92.18, 7.01 in-in in 7.958 Saltbr-in 3.264 HRD-in -83.66, -52.1 79.1, -13.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.36, 141.0 APE9-dihe-in -101.25, 92.23 APE8-dihe-out -59.77, -24.69 APE8-rot-na 330.6 APE67-dihe-in -77.73, -0.07 -57.66, -24.92 APE12-dist-na 17.39 APE11-dist-na 20.126 APE10-dist-na 17.109 APE9-dist-out 11.296 None None None XRAY 1.88 0.173 0.205 B 310 286 20 0 0 7 [[478, 756]] 1.0 9uhc TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
9UHIA 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.436 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.251 Saltbr-in 2.888 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.511 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.672 APE10-dist-na 16.685 APE9-dist-out 11.083 None None None XRAY 1.76 0.163 0.197 A 310 307 0 0 0 0 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
9UHIB 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.213 12.738 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.768 Saltbr-in 3.449 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.352 APE11-dist-na 20.682 APE10-dist-na 16.965 APE9-dist-out 11.364 None None None XRAY 1.76 0.163 0.197 B 310 286 20 0 0 7 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5A46A 464 766 822.0 38O:1769 Type1 Inactive DFGin 5.213 13.149 BLAplus -118.77, 162.9 58.04, 28.78 -73.18, -26.4 58.45, 90.15 -96.03, 5.5 in-in in 7.513 Saltbr-in 3.005 HRD-in -57.82, -48.72 70.95, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.0, 143.36 APE9-dihe-in -88.58, 110.07 APE8-dihe-out -58.5, -16.77 APE8-rot-na 337.71 APE67-dihe-in -76.67, -10.73 -63.67, -15.99 APE12-dist-na 20.033 APE11-dist-na 21.324 APE10-dist-na 19.432 APE9-dist-out 12.089 None None None XRAY 2.63 0.182 0.246 A 386 290 13 0 0 3 [[478, 756]] 1.0 5a46 TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5A46B 458 766 822.0 38O:1767 Type1 Inactive DFGin 5.33 12.787 BLAplus -120.14, 161.93 66.72, 19.6 -75.13, -22.14 56.34, 83.44 -97.38, -0.25 in-in in 7.593 Saltbr-in 2.799 HRD-in -68.23, -43.1 73.28, -14.2 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -119.49, 150.14 APE9-dihe-in -90.22, 111.65 APE8-dihe-out -53.72, -24.65 APE8-rot-na 331.17 APE67-dihe-in -66.01, -7.4 -51.07, -30.75 APE12-dist-na 20.292 APE11-dist-na 21.271 APE10-dist-na 19.907 APE9-dist-out 11.879 None None None XRAY 2.63 0.182 0.246 B 386 298 11 0 0 0 [[478, 756]] 1.0 5a46 TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWKB 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.737 13.232 BLAplus -119.15, 169.82 41.98, 44.21 -90.47, -9.61 54.08, 84.94 -94.37, 2.45 in-in in 8.416 Saltbr-in 3.448 HRD-in -74.45, -44.2 66.06, 8.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -133.04, 131.77 APE9-dihe-in -79.69, 122.84 APE8-dihe-out -69.38, -1.04 APE8-rot-na 339.66 APE67-dihe-in -75.83, -3.81 -84.39, -12.82 APE12-dist-na 999.0 APE11-dist-na 21.927 APE10-dist-na 19.835 APE9-dist-out 11.647 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 B 317 282 23 0 0 7 [[478, 756]] 1.0 4rwk TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3C4FA 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.114 13.318 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.866 Saltbr-out 4.632 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.292 APE11-dist-na 21.121 APE10-dist-na 19.395 APE9-dist-out 11.757 C488A None None XRAY 2.07 0.213 0.264 A 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3C4FB 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.186 13.096 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.831 Saltbr-in 3.248 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.934 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.37 APE11-dist-na 21.296 APE10-dist-na 19.671 APE9-dist-out 11.643 C488A None None XRAY 2.07 0.213 0.264 B 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3RHXA 464 764 822.0 3RH:2 Type1.5_Back Inactive DFGin 5.232 13.424 BLAplus -115.51, 162.57 65.19, 24.13 -75.33, -9.38 51.51, 92.3 -110.55, 8.31 in-in in 7.911 Saltbr-in 2.711 HRD-in -70.15, -54.52 80.53, -17.3 in-out-out SNCioo out-out ActLoopNT-out 8.954 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.48, 163.59 APE9-dihe-in -103.14, 115.59 APE8-dihe-out -45.87, -31.01 APE8-rot-na 329.03 APE67-dihe-in -73.43, -8.98 -55.07, -22.7 APE12-dist-na 19.77 APE11-dist-na 20.938 APE10-dist-na 19.62 APE9-dist-out 11.697 C488A,C584S None None XRAY 2.01 0.205 0.262 A 306 289 12 0 0 0 [[478, 756]] 1.0 3rhx TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3RHXB 461 761 822.0 3RH:1 Type1.5_Back Inactive DFGin 5.278 13.054 BLAplus -115.52, 168.31 59.14, 31.22 -88.71, -15.14 56.2, 82.95 -99.2, 10.03 in-in in 7.94 Saltbr-in 2.982 HRD-in -72.09, -51.52 83.53, -18.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.0, 155.03 APE9-dihe-in -98.71, 116.74 APE8-dihe-out -54.04, -23.88 APE8-rot-na 324.24 APE67-dihe-in -72.41, -9.32 -62.62, -17.17 APE12-dist-na 20.092 APE11-dist-na 21.395 APE10-dist-na 19.835 APE9-dist-out 11.621 C488A,C584S None None XRAY 2.01 0.205 0.262 B 306 275 26 0 0 6 [[478, 756]] 1.0 3rhx TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5A4CA 464 765 822.0 XOJ:61774 Type1.5_Back Inactive DFGin 5.048 13.267 BLAplus -116.37, 165.87 49.91, 42.78 -84.97, -10.47 49.36, 85.77 -124.76, 35.25 in-in in 7.785 Saltbr-in 2.773 HRD-in -70.73, -50.48 78.51, -17.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.99, 158.13 APE9-dihe-in -97.5, 110.29 APE8-dihe-out -57.36, -20.43 APE8-rot-na 331.74 APE67-dihe-in -71.92, -10.57 -60.66, -19.9 APE12-dist-na 19.861 APE11-dist-na 20.995 APE10-dist-na 19.495 APE9-dist-out 11.806 C488A,C584S None None XRAY 2.09 0.197 0.235 A 307 294 8 0 0 6 [[478, 756]] 1.0 5a4c TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5A4CB 461 765 822.0 XOJ:61772 Type1.5_Back Inactive DFGin 4.997 13.163 BLAplus -119.35, 160.02 53.79, 37.21 -79.91, -19.99 52.56, 81.88 -121.98, 47.25 in-in in 7.666 Saltbr-in 2.874 HRD-in -70.85, -51.35 80.75, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.16, 158.77 APE9-dihe-in -96.18, 111.18 APE8-dihe-out -54.21, -24.18 APE8-rot-na 331.2 APE67-dihe-in -62.46, -9.6 -52.41, -31.86 APE12-dist-na 20.081 APE11-dist-na 21.257 APE10-dist-na 19.71 APE9-dist-out 11.63 C488A,C584S None None XRAY 2.09 0.197 0.235 B 307 284 21 0 0 5 [[478, 756]] 1.0 5a4c TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4NK9B 460 765 822.0 2K5:802 Type1.5_Back Inactive DFGin 5.825 13.219 BLAplus -122.38, 146.16 46.72, 66.95 -88.33, 79.62 27.47, 86.37 49.01, 999.0 in-in in 8.041 Saltbr-in 3.369 HRD-in -55.1, -51.05 76.42, -8.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.43, 153.75 APE9-dihe-in -96.17, 112.02 APE8-dihe-out -57.11, -19.43 APE8-rot-na 333.43 APE67-dihe-in -71.52, -2.84 -61.88, -22.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.773 C488A,C584S None None XRAY 2.57 0.209 0.262 B 309 282 24 0 0 8 [[478, 756]] 1.0 4nk9 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4V05A 464 765 822.0 66T:1769 Type1.5_Back Inactive DFGin 5.473 13.42 BLAplus -110.72, 173.08 50.09, 39.57 -95.62, -19.67 60.09, 83.48 -87.99, 3.34 in-in in 8.048 Saltbr-in 2.75 HRD-in -64.72, -51.32 77.65, -23.6 in-out-out SNCioo out-out ActLoopNT-out 8.302 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.91, 158.86 APE9-dihe-in -104.86, 116.5 APE8-dihe-out -57.09, -23.19 APE8-rot-na 335.63 APE67-dihe-in -66.78, -18.31 -54.95, -24.99 APE12-dist-na 20.841 APE11-dist-na 21.808 APE10-dist-na 19.911 APE9-dist-out 11.602 None None None XRAY 2.57 0.196 0.256 A 309 287 15 0 0 4 [[478, 756]] 1.0 4v05 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4V05B 459 764 822.0 66T:1767 Type1.5_Back Inactive DFGin 5.427 13.072 BLAplus -110.08, 173.06 48.31, 47.35 -106.86, -10.85 58.74, 86.16 -77.17, -18.0 in-in in 7.831 Saltbr-in 2.983 HRD-in -65.29, -47.82 74.06, -21.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.03, 160.1 APE9-dihe-in -100.97, 109.95 APE8-dihe-out -53.4, -23.19 APE8-rot-na 333.98 APE67-dihe-in -59.05, -11.55 -51.93, -35.21 APE12-dist-na 21.391 APE11-dist-na 22.089 APE10-dist-na 20.538 APE9-dist-out 11.465 None None None XRAY 2.57 0.196 0.256 B 309 286 20 0 0 4 [[478, 756]] 1.0 4v05 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5EW8A 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.948 13.265 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.954 Saltbr-in 2.801 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.37 APE11-dist-na 20.743 APE10-dist-na 19.216 APE9-dist-out 11.882 None None None XRAY 1.63 0.186 0.206 A 309 291 11 0 0 0 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5EW8B 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.002 13.124 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.88 Saltbr-in 2.807 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.38 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.902 APE11-dist-na 21.169 APE10-dist-na 19.654 APE9-dist-out 11.767 None None None XRAY 1.63 0.186 0.206 B 309 290 15 0 0 2 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
2FGIA 464 762 822.0 PD1:1001 Type1.5_Back Inactive DFGin 5.121 13.427 BLAplus -112.68, 157.47 60.87, 36.89 -81.98, -32.37 53.09, 90.73 -98.47, 17.45 in-in in 7.747 Saltbr-in 2.901 HRD-in -72.72, -53.18 83.95, -27.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -126.75, 157.3 APE9-dihe-in -97.93, 112.9 APE8-dihe-out -58.5, -25.56 APE8-rot-na 326.54 APE67-dihe-in -72.23, -8.06 -59.01, -20.89 APE12-dist-na 19.922 APE11-dist-na 21.175 APE10-dist-na 19.322 APE9-dist-out 11.544 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 A 310 274 25 0 0 2 [[478, 756]] 1.0 2fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
2FGIB 461 761 822.0 PD1:1000 Type1.5_Back Inactive DFGin 5.065 13.208 BLAplus -127.21, 161.09 62.19, 18.94 -71.59, -20.95 56.29, 90.56 -106.4, 12.05 in-in in 7.776 Saltbr-in 3.066 HRD-in -62.08, -49.35 70.47, -0.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.38, 171.1 APE9-dihe-in -103.55, 110.23 APE8-dihe-out -52.66, -22.87 APE8-rot-na 324.05 APE67-dihe-in -65.07, -15.18 -62.56, -23.42 APE12-dist-na 999.0 APE11-dist-na 20.195 APE10-dist-na 19.456 APE9-dist-out 11.655 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 B 310 272 29 0 0 9 [[478, 756]] 1.0 2fgi TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5B7VA 464 763 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.579 13.122 BLAplus -124.02, 164.1 56.03, 35.18 -83.98, -18.11 54.48, 82.39 -93.9, 14.98 in-in in 7.675 Saltbr-in 3.025 HRD-in -66.75, -56.97 82.51, -19.31 in-out-out SNCioo out-out ActLoopNT-out 8.581 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.75, 145.14 APE9-dihe-in -88.05, 111.6 APE8-dihe-out -54.86, -24.86 APE8-rot-na 336.86 APE67-dihe-in -69.24, -8.96 -56.43, -23.01 APE12-dist-na 20.966 APE11-dist-na 21.63 APE10-dist-na 19.658 APE9-dist-out 12.019 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 A 310 282 18 0 0 3 [[478, 756]] 1.0 5b7v TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4WUNA 465 765 822.0 66T:801 Type1.5_Back Inactive DFGin 5.359 13.287 BLAplus -114.51, 167.45 61.45, 33.19 -92.75, -3.72 56.8, 81.8 -94.63, -9.82 in-in in 7.925 Saltbr-in 2.943 HRD-in -77.57, -50.47 80.03, -11.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -31.68 APE8-rot-na 335.8 APE67-dihe-in -71.2, -7.75 -54.8, -30.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.65 0.226 0.247 A 311 282 19 0 0 18 [[478, 756]] 1.0 4wun TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4WUNB 461 762 822.0 66T:801 Type1.5_Back Inactive DFGin 5.239 13.104 BLAplus -116.49, 163.26 61.87, 38.6 -99.56, -5.62 55.6, 83.98 -99.35, -2.08 in-in in 7.704 Saltbr-in 2.667 HRD-in -74.96, -47.89 70.35, -11.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 81.94 APE8-dihe-out -59.03, -20.07 APE8-rot-na 4.38 APE67-dihe-in -66.47, -11.9 -63.08, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.202 None None None XRAY 1.65 0.226 0.247 B 311 268 34 0 0 17 [[478, 756]] 1.0 4wun TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5UR1A 464 765 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.426 13.52 BLAplus -105.89, 156.77 50.9, 45.08 -90.42, 1.33 56.15, 80.94 -119.23, 19.57 in-in in 8.119 Saltbr-in 2.874 HRD-in -68.09, -57.16 83.23, -8.89 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -37.48 APE8-rot-na 0.79 APE67-dihe-in -68.25, -11.12 -55.14, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 A 311 278 24 0 0 18 [[478, 756]] 1.0 5ur1 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C18A 465 765 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.436 13.468 BLAplus -111.24, 164.85 45.25, 45.5 -89.65, 12.35 52.19, 85.8 -112.52, 6.73 in-in in 8.115 Saltbr-in 2.978 HRD-in -70.43, -53.82 83.18, -8.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.11 APE8-rot-na 0.21 APE67-dihe-in -78.22, -8.43 -50.66, -26.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 A 311 276 25 0 0 18 [[478, 756]] 1.0 6c18 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C19A 464 765 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.26 13.442 BLAplus -115.0, 156.31 53.23, 42.1 -90.35, 7.6 54.35, 87.97 -114.31, 9.09 in-in in 8.0 Saltbr-in 2.759 HRD-in -69.01, -56.23 81.64, -20.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 102.7 APE8-dihe-out -60.85, -19.74 APE8-rot-na 1.27 APE67-dihe-in -75.51, -3.9 -52.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.319 None None None XRAY 2.12 0.207 0.239 A 311 276 26 0 0 17 [[478, 756]] 1.0 6c19 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C19B 464 762 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.425 13.275 BLAplus -112.97, 152.62 61.65, 40.35 -91.96, -0.71 58.29, 80.73 -101.35, 18.35 in-in in 7.888 Saltbr-in 2.677 HRD-in -74.47, -50.19 73.43, -16.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 88.31 APE8-dihe-out -50.83, -20.72 APE8-rot-na 330.47 APE67-dihe-in -67.26, -8.41 -54.06, -29.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.219 None None None XRAY 2.12 0.207 0.239 B 311 264 35 0 0 17 [[478, 756]] 1.0 6c19 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C1BA 465 765 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.481 13.494 BLAplus -108.99, 153.45 58.08, 39.21 -83.57, -0.28 58.99, 81.41 -115.03, 23.43 in-in in 7.962 Saltbr-in 2.714 HRD-in -69.38, -56.84 85.63, -18.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.26 APE8-rot-na 2.4 APE67-dihe-in -77.29, -7.48 -43.43, -29.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.0 0.222 0.255 A 311 265 36 0 0 18 [[478, 756]] 1.0 6c1b TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C1BB 463 762 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.39 13.173 BLAplus -111.61, 149.0 60.67, 36.26 -77.03, -12.36 51.44, 84.41 -47.03, -51.79 in-in in 7.747 Saltbr-in 2.717 HRD-in -68.12, -50.23 87.75, -19.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 84.87 APE8-dihe-out -57.93, -21.43 APE8-rot-na 10.08 APE67-dihe-in -70.65, -8.86 -55.2, -24.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.308 C488A,C584S None None XRAY 2.0 0.222 0.255 B 311 256 44 0 0 17 [[478, 756]] 1.0 6c1b TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C1CA 465 765 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.567 13.493 BLAplus -110.74, 156.89 46.01, 46.87 -92.39, 20.43 55.59, 84.88 -142.57, 39.38 in-in in 8.073 Saltbr-in 2.784 HRD-in -74.71, -57.54 87.89, -21.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.9 APE8-rot-na 351.03 APE67-dihe-in -75.96, -1.2 -53.74, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.15 0.228 0.27 A 311 276 25 0 0 18 [[478, 756]] 1.0 6c1c TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C1CB 463 763 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.254 13.146 BLAplus -106.04, 150.67 54.89, 44.71 -87.15, 1.28 50.78, 77.72 -105.41, 5.99 in-in in 7.72 Saltbr-in 2.618 HRD-in -67.33, -48.84 84.75, -22.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.16 APE8-dihe-out -62.72, -16.38 APE8-rot-na 19.67 APE67-dihe-in -70.81, -7.72 -62.98, -22.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.411 C488A,C584S None None XRAY 2.15 0.228 0.27 B 311 267 34 0 0 16 [[478, 756]] 1.0 6c1c TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C1OA 464 765 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.367 13.476 BLAplus -110.66, 158.04 49.97, 55.76 -104.93, -8.0 57.72, 84.41 -107.33, 33.26 in-in in 7.751 Saltbr-in 2.914 HRD-in -67.38, -50.88 76.07, -0.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.74 APE8-dihe-out -57.13, -28.25 APE8-rot-na 348.02 APE67-dihe-in -72.73, -9.95 -55.13, -30.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.08 C488A,C584S None None XRAY 2.29 0.239 0.276 A 311 280 22 0 0 17 [[478, 756]] 1.0 6c1o TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C1OB 464 763 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.252 13.353 BLAplus -111.97, 154.41 51.29, 49.54 -91.74, -22.47 56.2, 81.11 -92.83, 58.93 in-in in 7.916 Saltbr-in 3.174 HRD-in -68.78, -49.64 75.13, -1.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.32 APE8-rot-na 337.06 APE67-dihe-in -73.03, -7.64 -66.65, -25.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.29 0.239 0.276 B 311 262 38 0 0 18 [[478, 756]] 1.0 6c1o TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6MZQA 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.099 13.258 BLAplus -119.38, 163.65 62.35, 33.69 -91.12, -0.33 55.27, 84.16 -120.86, 13.76 in-in in 7.949 Saltbr-in 2.678 HRD-in -73.6, -55.96 80.43, -5.0 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.61 APE8-rot-na 334.89 APE67-dihe-in -72.0, -8.25 -68.04, -26.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 A 311 277 24 0 0 18 [[478, 756]] 1.0 6mzq TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6MZQB 462 761 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.229 13.06 BLAplus -109.43, 157.46 65.55, 34.29 -83.47, -21.73 59.11, 82.16 -85.45, 999.0 in-in in 7.783 Saltbr-in 2.85 HRD-in -69.06, -55.52 76.96, -3.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -39.35 APE8-rot-na 334.65 APE67-dihe-in -70.64, -10.51 -51.58, -30.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 B 311 260 40 0 0 19 [[478, 756]] 1.0 6mzq TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWJA 458 764 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.264 13.557 BLAplus -111.1, 165.72 44.3, 59.14 -104.5, -7.94 52.98, 85.2 -108.93, 18.9 in-in in 8.064 Saltbr-in 3.125 HRD-in -76.03, -43.68 72.99, -8.16 in-out-out SNCioo out-out ActLoopNT-out 7.982 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.41, 138.95 APE9-dihe-in -108.01, 100.05 APE8-dihe-out -61.04, -14.23 APE8-rot-na 22.4 APE67-dihe-in -81.18, -2.01 -65.12, -23.42 APE12-dist-na 19.426 APE11-dist-na 20.457 APE10-dist-na 17.046 APE9-dist-out 11.32 C488A,C584S None None XRAY 2.489 0.204 0.25 A 317 306 1 0 0 1 [[478, 756]] 1.0 4rwj TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWJB 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.306 13.075 BLAplus -111.81, 166.65 44.09, 58.11 -104.8, -5.62 52.57, 84.61 -105.75, 19.27 in-in in 7.934 Saltbr-in 2.835 HRD-in -75.88, -44.44 70.84, -6.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.6, 139.99 APE9-dihe-in -106.55, 102.92 APE8-dihe-out -58.58, -14.6 APE8-rot-na 336.03 APE67-dihe-in -80.58, -2.45 -66.06, -21.44 APE12-dist-na 999.0 APE11-dist-na 21.707 APE10-dist-na 18.478 APE9-dist-out 11.547 C488A,C584S None None XRAY 2.489 0.204 0.25 B 317 282 23 0 0 10 [[478, 756]] 1.0 4rwj TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3GQLA 463 774 822.0 GQL:1 Type1.5_Back Inactive DFGin 5.247 12.989 BLAplus -123.12, 162.21 54.12, 42.77 -89.74, -13.17 56.15, 71.6 -109.47, 50.5 in-in in 7.903 Saltbr-in 2.834 HRD-in -61.52, -47.63 72.57, -4.79 in-out-out SNCioo out-out ActLoopNT-out 8.925 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -142.49, 22.73 APE9-dihe-out 65.92, 53.77 APE8-dihe-out -55.03, -39.73 APE8-rot-na 329.92 APE67-dihe-in -69.54, -5.25 -36.43, -34.58 APE12-dist-na 16.321 APE11-dist-na 15.25 APE10-dist-na 15.999 APE9-dist-out 11.315 C488A None None XRAY 2.8 0.252 0.289 A 326 287 25 0 0 12 [[478, 756]] 1.0 3gql TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3TT0A 461 765 822.0 07J:1 Type1.5_Back Inactive DFGin 5.254 13.639 BLAplus -115.26, 155.31 53.22, 40.23 -81.24, -26.95 55.14, 87.79 -91.68, 21.07 in-in in 7.915 Saltbr-in 3.106 HRD-in -69.95, -51.8 74.05, -16.9 in-out-out SNCioo out-out ActLoopNT-out 7.614 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.94, 147.79 APE9-dihe-in -106.75, 107.95 APE8-dihe-out -68.73, -19.6 APE8-rot-na 342.28 APE67-dihe-in -78.56, -18.08 -54.41, -25.03 APE12-dist-na 17.102 APE11-dist-na 19.47 APE10-dist-na 16.731 APE9-dist-out 11.071 C584S None None XRAY 2.8 0.207 0.261 A 382 305 0 0 0 0 [[478, 756]] 1.0 3tt0 TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3TT0B 459 763 822.0 07J:1 Type1.5_Back Inactive DFGin 5.382 13.307 BLAplus -116.49, 155.58 53.39, 40.81 -79.81, -25.38 49.88, 91.88 -91.88, 20.46 in-in in 7.848 Saltbr-in 3.041 HRD-in -67.66, -50.02 73.72, -9.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 146.21 APE8-rot-na 352.76 APE67-dihe-out -93.95, -12.68 76.26, -23.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.8 0.207 0.261 B 382 272 33 0 0 17 [[478, 756]] 1.0 3tt0 TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8Y22A 459 762 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 5.106 13.179 BLAplus -113.25, 160.17 59.08, 34.01 -79.21, -14.36 51.54, 87.27 -109.45, 13.99 in-in in 7.982 Saltbr-in 2.799 HRD-in -70.73, -44.6 68.63, 0.76 in-out-out SNCioo out-out ActLoopNT-out 9.029 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.2, 162.84 APE9-dihe-in -99.13, 115.53 APE8-dihe-out -57.19, -22.1 APE8-rot-na 334.84 APE67-dihe-in -76.32, -7.85 -61.99, -21.14 APE12-dist-na 19.645 APE11-dist-na 20.883 APE10-dist-na 19.478 APE9-dist-out 11.673 C584S None None XRAY 2.792 0.197 0.26 A 308 288 16 0 0 4 [[478, 756]] 1.0 8y22 TYR_FGFR1_HUMAN TYR 2e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8Y22B 463 765 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 4.927 13.386 BLAplus -106.53, 165.87 49.37, 36.23 -76.81, -19.53 50.68, 85.1 -111.75, 14.63 in-in in 8.152 Saltbr-in 2.793 HRD-in -74.01, -46.1 72.79, 0.75 in-out-out SNCioo out-out ActLoopNT-out 8.596 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.29, 150.81 APE9-dihe-in -94.3, 115.55 APE8-dihe-out -59.96, -16.81 APE8-rot-na 335.23 APE67-dihe-in -86.59, -1.86 -68.36, -9.3 APE12-dist-na 19.374 APE11-dist-na 20.919 APE10-dist-na 19.145 APE9-dist-out 11.734 C584S None None XRAY 2.792 0.197 0.26 B 308 291 12 0 0 0 [[478, 756]] 1.0 8y22 TYR_FGFR1_HUMAN TYR 2e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6NVLA 463 765 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.128 13.311 BLAplus -119.52, 157.53 59.31, 34.82 -84.42, -16.16 59.33, 82.45 -101.42, 33.52 in-in in 7.59 Saltbr-in 2.865 HRD-in -75.42, -53.52 80.47, -2.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.68, 147.97 APE9-dihe-in -112.42, 91.75 APE8-dihe-out -47.21, -34.96 APE8-rot-na 327.61 APE67-dihe-in -66.06, -15.18 -49.22, -31.67 APE12-dist-na 17.287 APE11-dist-na 20.56 APE10-dist-na 17.182 APE9-dist-out 11.624 C584S None None XRAY 2.7 0.215 0.263 A 309 280 23 0 0 9 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6NVLB 461 761 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.29 13.112 BLAplus -110.71, 154.52 49.9, 58.02 -103.43, -14.13 54.73, 82.29 -99.41, 13.49 in-in in 7.623 Saltbr-in 3.025 HRD-in -62.36, -64.19 100.95, -30.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.63 APE8-rot-na 324.79 APE67-dihe-in -73.34, -7.41 -51.06, -32.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 B 309 263 38 0 0 18 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6NVLC 465 761 822.0 XL6:801 Type1.5_Back Inactive DFGin 5.396 13.396 BLAplus -121.16, 162.24 42.87, 55.81 -103.48, -8.54 57.38, 81.17 -97.02, -26.48 in-in in 7.522 Saltbr-in 3.154 HRD-in -69.09, -49.97 76.47, -2.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -35.16 APE8-rot-na 328.72 APE67-dihe-in -78.06, -0.48 -64.76, -24.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 C 309 265 32 0 0 9 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6NVLD 471 762 822.0 XL6:804 Type1.5_Back Inactive DFGin 5.158 13.31 BLAplus -117.28, 161.88 52.71, 45.04 -93.07, -6.01 60.08, 84.31 -96.46, -42.94 in-none in 7.363 Saltbr-none 999.0 HRD-in -74.01, -57.04 84.17, -3.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.3, 154.56 APE9-dihe-in -112.92, 85.91 APE8-dihe-out -57.48, -12.84 APE8-rot-na 334.14 APE67-dihe-in -78.36, -8.15 -65.38, -24.93 APE12-dist-na 16.47 APE11-dist-na 19.401 APE10-dist-na 16.585 APE9-dist-out 11.335 C584S None None XRAY 2.7 0.215 0.263 D 309 269 23 0 0 9 [[478, 756]] 1.0 6nvl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7WCLA 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.032 13.511 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.234 Saltbr-in 2.943 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.725 APE11-dist-na 19.067 APE10-dist-na 16.226 APE9-dist-out 11.223 C584S None None XRAY 2.495 0.195 0.23 A 310 306 0 0 0 0 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
7WCLB 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.686 13.297 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.381 Saltbr-in 2.804 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.605 APE10-dist-na 19.498 APE9-dist-out 11.402 C584S None None XRAY 2.495 0.195 0.23 B 310 285 21 0 0 8 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8XLOA 462 764 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.35 13.46 BLAplus -120.07, 167.95 56.19, 37.83 -98.04, 4.56 56.68, 90.6 -112.93, 25.35 in-in in 7.983 Saltbr-in 3.258 HRD-out -75.5, 142.74 -82.57, -37.38 in-out-out SNCioo out-out ActLoopNT-out 7.2 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.57, 158.46 APE9-dihe-in -97.47, 110.21 APE8-dihe-out -58.39, -18.54 APE8-rot-na 19.21 APE67-dihe-in -81.65, 0.42 -62.39, -18.82 APE12-dist-na 20.741 APE11-dist-na 21.946 APE10-dist-na 20.212 APE9-dist-out 11.778 C584S None None XRAY 2.36 0.21 0.255 A 310 293 10 0 0 0 [[478, 756]] 1.0 8xlo TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8XLOB 458 763 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.588 13.187 BLAplus -122.66, 168.69 59.17, 27.93 -79.17, -12.14 48.47, 88.63 -115.21, 3.75 in-in in 7.768 Saltbr-in 2.883 HRD-out -89.09, 129.19 -58.3, -36.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.09, 159.35 APE9-dihe-in -98.63, 108.84 APE8-dihe-out -54.34, -25.08 APE8-rot-na 331.75 APE67-dihe-in -70.85, 2.53 -59.01, -24.97 APE12-dist-na 19.448 APE11-dist-na 20.738 APE10-dist-na 19.3 APE9-dist-out 11.712 C584S None None XRAY 2.36 0.21 0.255 B 310 287 19 0 0 6 [[478, 756]] 1.0 8xlo TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8XZ7B 461 765 822.0 A1LWW:60804 Type1.5_Back Inactive DFGin 5.277 13.486 BLAplus -115.92, 158.14 64.67, 33.78 -87.5, -12.64 58.12, 85.71 -91.55, 13.39 in-in in 8.268 Saltbr-in 2.974 HRD-in -72.69, -49.53 74.85, -11.34 in-out-out SNCioo out-out ActLoopNT-out 7.698 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -73.13, 157.52 APE9-dihe-in -120.81, 83.94 APE8-dihe-out -59.26, -16.83 APE8-rot-na 351.23 APE67-dihe-in -76.52, -7.27 -60.13, -24.1 APE12-dist-na 17.884 APE11-dist-na 19.581 APE10-dist-na 16.754 APE9-dist-out 11.09 C584S None None XRAY 1.75 0.188 0.225 B 310 303 2 0 0 0 [[478, 756]] 1.0 8xz7 TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6MZWA 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 4.822 13.4 BLAplus -122.44, 164.99 57.07, 40.5 -90.84, 9.02 55.25, 82.2 -134.07, 2.85 in-in in 8.004 Saltbr-in 2.819 HRD-in -69.57, -56.52 83.74, -8.47 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.34 APE8-rot-na 329.11 APE67-dihe-in -82.69, 5.42 -51.99, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 A 311 282 20 0 0 18 [[478, 756]] 1.0 6mzw TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5VNDA 463 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.228 13.425 BLAplus -118.27, 161.79 56.96, 41.78 -93.83, -18.18 57.16, 83.64 -76.46, -2.88 in-in in 7.706 Saltbr-in 3.011 HRD-in -76.4, -51.16 70.96, 1.97 in-out-out SNCioo out-out ActLoopNT-out 8.385 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.26, 154.9 APE9-dihe-in -95.33, 115.63 APE8-dihe-out -58.5, -20.28 APE8-rot-na 328.5 APE67-dihe-in -71.98, -7.89 -57.67, -20.31 APE12-dist-na 20.247 APE11-dist-na 21.387 APE10-dist-na 19.746 APE9-dist-out 11.797 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 A 309 302 1 0 0 1 [[478, 756]] 1.0 5vnd TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5VNDB 460 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.286 13.219 BLAplus -116.66, 159.84 60.5, 40.74 -88.83, -28.65 56.85, 87.63 -76.11, -9.05 in-in in 7.643 Saltbr-in 3.135 HRD-in -75.25, -50.66 71.68, -1.94 in-out-out SNCioo out-out ActLoopNT-out 7.972 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.48, 159.45 APE9-dihe-in -96.83, 113.88 APE8-dihe-out -57.87, -23.88 APE8-rot-na 336.6 APE67-dihe-in -71.96, -8.45 -53.4, -22.22 APE12-dist-na 20.168 APE11-dist-na 21.399 APE10-dist-na 19.928 APE9-dist-out 11.65 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 B 309 295 11 0 0 0 [[478, 756]] 1.0 5vnd TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6P68A 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.568 13.297 BLAplus -124.18, 155.54 63.3, 48.78 -90.25, -51.15 37.68, 89.45 -72.78, 42.85 in-in in 8.463 Saltbr-in 3.068 HRD-in -82.33, -55.3 90.45, -28.65 in-out-out SNCioo out-out ActLoopNT-out 9.254 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.44, 166.09 APE9-dihe-in -115.93, 115.43 APE8-dihe-out -43.99, -17.59 APE8-rot-na 319.34 APE67-dihe-in -77.38, -22.95 -75.44, -11.63 APE12-dist-na 20.714 APE11-dist-na 21.756 APE10-dist-na 19.655 APE9-dist-out 11.592 C488A,Y563C None None XRAY 2.9 0.23 0.303 A 309 287 15 0 0 3 [[478, 756]] 1.0 6p68 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6P68B 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.5 13.362 BLAplus -127.31, 162.51 46.96, 56.83 -101.23, -42.4 47.99, 77.97 -84.27, 46.6 in-in in 7.758 Saltbr-in 3.302 HRD-in -84.02, -53.61 84.39, -26.28 in-out-out SNCioo out-out ActLoopNT-out 8.846 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.18, 175.15 APE9-dihe-in -113.49, 131.98 APE8-dihe-out -57.6, -24.27 APE8-rot-na 330.67 APE67-dihe-in -68.05, -15.43 -68.07, -21.93 APE12-dist-na 20.753 APE11-dist-na 22.182 APE10-dist-na 20.562 APE9-dist-out 11.666 C488A,Y563C None None XRAY 2.9 0.23 0.303 B 309 286 16 0 0 3 [[478, 756]] 1.0 6p68 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6P68C 463 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.821 13.216 BLAplus -111.29, 171.43 44.74, 37.04 -76.15, -58.04 39.05, 94.26 -70.98, 63.26 in-in in 7.372 Saltbr-in 2.885 HRD-in -80.62, -45.97 77.53, -19.73 in-out-out SNCioo out-out ActLoopNT-out 8.29 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.73, 161.83 APE9-dihe-in -111.63, 125.51 APE8-dihe-out -59.61, -24.78 APE8-rot-na 332.23 APE67-dihe-in -70.27, -21.8 -56.16, -23.37 APE12-dist-na 20.336 APE11-dist-na 21.442 APE10-dist-na 19.226 APE9-dist-out 11.324 C488A,Y563C None None XRAY 2.9 0.23 0.303 C 309 286 15 0 0 3 [[478, 756]] 1.0 6p68 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6P69A 462 765 822.0 O21:804 Type1.5_Back Inactive DFGin 5.293 13.332 BLAplus -116.62, 153.51 68.44, 36.07 -94.14, -3.31 60.05, 82.99 -102.25, 17.21 in-in in 7.678 Saltbr-in 2.829 HRD-in -76.03, -50.91 79.25, -13.3 in-out-out SNCioo out-out ActLoopNT-out 6.92 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.91, 156.78 APE9-dihe-in -97.6, 112.94 APE8-dihe-out -56.34, -25.16 APE8-rot-na 341.33 APE67-dihe-in -73.31, -6.91 -51.65, -21.86 APE12-dist-na 20.852 APE11-dist-na 22.153 APE10-dist-na 20.372 APE9-dist-out 11.595 C488A,Y563C None None XRAY 2.2 0.189 0.245 A 309 288 16 0 0 0 [[478, 756]] 1.0 6p69 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6P69B 461 762 822.0 O21:804 Type1.5_Back Inactive DFGin 5.238 12.992 BLAplus -110.73, 150.1 69.98, 35.36 -92.92, -8.35 56.07, 83.61 -81.3, 13.2 in-in in 7.674 Saltbr-in 2.723 HRD-in -71.89, -48.99 79.15, -25.42 in-out-out SNCioo out-out ActLoopNT-out 7.41 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.29, 160.07 APE9-dihe-in -97.38, 114.82 APE8-dihe-out -64.56, -21.47 APE8-rot-na 332.49 APE67-dihe-in -69.85, -7.92 -52.16, -22.61 APE12-dist-na 20.522 APE11-dist-na 21.686 APE10-dist-na 19.964 APE9-dist-out 11.454 C488A,Y563C None None XRAY 2.2 0.189 0.245 B 309 286 16 0 0 0 [[478, 756]] 1.0 6p69 TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3KXXA 461 765 822.0 No_ligand No_ligand Inactive DFGin 6.889 14.259 BLBminus -140.37, -169.46 63.26, 50.32 -78.18, 162.76 296.3, 66.09 151.64, -37.0 in-in in 7.017 Saltbr-in 2.83 HRD-out -100.04, 84.29 -55.69, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.55, 44.24 APE9-dihe-in -122.5, 136.32 APE8-dihe-in -50.57, 127.21 APE8-rot-na 327.84 APE67-dihe-in -76.36, 2.91 -67.27, -29.4 APE12-dist-na 14.337 APE11-dist-na 9.735 APE10-dist-na 7.861 APE9-dist-in 5.347 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 A 317 305 0 0 0 0 [[478, 756]] 1.0 3kxx TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8JQIB 463 769 822.0 No_ligand No_ligand Inactive DFGin 5.58 13.702 BLBplus -110.39, 162.0 66.1, 18.22 -83.81, 164.72 63.85, 90.92 69.71, 13.55 in-in in 8.148 Saltbr-in 2.879 HRD-in -62.9, -42.83 68.84, -8.19 in-out-in SNCioi out-in ActLoopNT-out 7.708 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.84, 130.26 APE9-dihe-in -65.71, 153.24 APE8-dihe-in -72.54, 69.48 APE8-rot-na 18.0 APE67-dihe-in -81.24, 0.42 -61.21, -30.47 APE12-dist-na 18.004 APE11-dist-na 14.233 APE10-dist-na 16.408 APE9-dist-in 6.971 None None None EM 4.1 999.0 999.0 B 822 307 0 0 0 0 [[478, 756]] 1.0 8jqi TYR_FGFR1_HUMAN TYR 3e-103 351.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8YKIA 464 762 822.0 A1LY1:60801 Type1 Inactive DFGin 5.678 13.189 BLBplus -127.03, 161.47 55.43, 32.07 -78.75, 135.31 51.37, 81.9 67.66, 33.8 in-in in 7.996 Saltbr-in 3.228 HRD-in -69.63, -52.14 73.54, -1.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.66 APE8-dihe-out -68.91, -19.3 APE8-rot-na 29.84 APE67-dihe-in -67.55, -18.75 -54.73, -36.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.057 C488A None None XRAY 2.79 0.242 0.288 A 317 267 32 0 0 16 [[478, 756]] 1.0 8yki TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8YKIB 461 761 822.0 A1LY1:60801 Type1 Inactive DFGin 5.816 13.002 BLBplus -127.51, 162.85 54.9, 31.45 -78.58, 134.89 51.65, 81.41 96.69, -107.12 in-in in 7.968 Saltbr-in 3.228 HRD-in -70.15, -51.98 73.59, -0.57 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.54 APE8-dihe-out -68.77, -19.51 APE8-rot-na 29.46 APE67-dihe-in -66.31, -19.61 -55.9, -35.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.131 C488A None None XRAY 2.79 0.242 0.288 B 317 264 37 0 0 17 [[478, 756]] 1.0 8yki TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
3GQLB 463 765 822.0 GQL:1 Type1 Inactive DFGin 5.609 13.296 BLBplus -128.62, 167.94 48.28, 62.54 -111.2, 147.65 41.12, 83.15 54.74, 40.27 in-in in 8.088 Saltbr-in 2.95 HRD-in -58.11, -48.09 70.35, -6.25 in-out-none SNCion out-none ActLoopNT-out 8.853 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.24 APE8-rot-na 35.42 APE67-dihe-in -73.56, 1.23 -76.55, -20.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 B 326 276 27 0 0 16 [[478, 756]] 1.0 3gql TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
8XZ7A 458 765 822.0 A1LWW:60803 Type1 Inactive DFGin 5.582 13.023 BLBplus -119.64, 153.34 65.26, 30.33 -76.98, 170.32 51.66, 84.53 -174.68, 170.61 in-in in 8.21 Saltbr-in 2.896 HRD-out -86.18, 131.57 -68.41, -19.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.72, 163.01 APE9-dihe-in -98.35, 111.69 APE8-dihe-out -59.15, -22.66 APE8-rot-na 330.38 APE67-dihe-in -69.43, -4.98 -58.15, -24.4 APE12-dist-na 25.284 APE11-dist-na 26.442 APE10-dist-na 23.918 APE9-dist-out 11.351 C584S None None XRAY 1.75 0.188 0.225 A 310 297 11 0 0 4 [[478, 756]] 1.0 8xz7 TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5ZV2A 463 762 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.568 14.144 BLBplus -131.08, 166.37 55.4, 22.07 -76.03, 127.13 51.59, 83.66 103.79, -116.47 in-in in 7.858 Saltbr-in 3.143 HRD-in -69.2, -53.37 81.07, -9.59 in-out-out SNCioo out-out ActLoopNT-out 9.185 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -156.95, 137.73 APE9-dihe-in -102.4, 101.23 APE8-dihe-out -65.35, -22.62 APE8-rot-na 30.52 APE67-dihe-in -64.41, -13.08 -61.44, -25.69 APE12-dist-na 18.712 APE11-dist-na 21.068 APE10-dist-na 17.839 APE9-dist-out 12.103 C488A None None XRAY 2.86 0.215 0.269 A 305 284 16 0 0 2 [[478, 756]] 1.0 5zv2 TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5ZV2B 461 764 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.735 13.333 BLBplus -131.99, 168.42 59.16, 17.33 -69.91, 121.62 49.14, 91.18 109.73, -109.09 in-in in 7.949 Saltbr-in 2.867 HRD-in -69.21, -53.97 80.59, -9.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 120.68 APE9-dihe-in -90.2, 111.18 APE8-dihe-out -62.93, -18.78 APE8-rot-na 29.94 APE67-dihe-in -66.68, -14.01 -56.35, -27.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.926 APE9-dist-out 11.61 C488A None None XRAY 2.86 0.215 0.269 B 305 281 23 0 0 10 [[478, 756]] 1.0 5zv2 TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4NK9A 464 765 822.0 2K5:807 Type1.5_Back Inactive DFGin 5.643 13.358 BLBplus -109.95, 156.55 39.62, 77.0 -103.05, 153.56 28.96, 73.43 57.1, 999.0 in-in in 8.098 Saltbr-in 3.363 HRD-in -55.46, -49.38 77.25, -13.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.12, 153.38 APE9-dihe-in -96.1, 111.38 APE8-dihe-out -57.95, -18.94 APE8-rot-na 334.9 APE67-dihe-in -71.02, -3.8 -60.59, -24.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.893 C488A,C584S None None XRAY 2.57 0.209 0.262 A 309 281 21 0 0 7 [[478, 756]] 1.0 4nk9 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5B7VB 462 762 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.677 12.94 BLBplus -116.05, 161.84 53.01, 39.08 -76.06, 133.86 41.64, 92.29 65.64, 39.87 in-in in 7.617 Saltbr-in 3.029 HRD-in -64.13, -51.82 87.54, -28.51 in-out-out SNCioo out-out ActLoopNT-out 9.441 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -94.62, 144.39 APE9-dihe-in -82.91, 115.57 APE8-dihe-out -50.0, -27.69 APE8-rot-na 330.02 APE67-dihe-in -70.22, -11.34 -61.05, -21.38 APE12-dist-na 999.0 APE11-dist-na 19.998 APE10-dist-na 18.243 APE9-dist-out 11.702 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 B 310 277 24 0 0 6 [[478, 756]] 1.0 5b7v TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
5UR1B 464 763 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.291 13.248 BLBplus -105.41, 154.97 53.57, 37.31 -77.11, 166.16 58.26, 86.17 69.33, 25.51 in-in in 7.618 Saltbr-in 2.596 HRD-in -63.24, -51.37 83.2, -13.32 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -28.36 APE8-rot-na 342.42 APE67-dihe-in -76.21, -4.72 -69.35, -13.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 B 311 265 35 0 0 18 [[478, 756]] 1.0 5ur1 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4RWLB 458 764 822.0 3ZC:801 Type1.5_Back Inactive DFGin 5.575 12.86 BLBplus -118.6, 158.89 63.82, 31.02 -77.01, 152.77 46.13, 88.04 75.46, -144.53 in-in in 7.864 Saltbr-in 2.714 HRD-in -76.64, -55.25 80.83, -9.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.43, 164.04 APE9-dihe-in -102.17, 112.77 APE8-dihe-out -51.59, -26.38 APE8-rot-na 327.68 APE67-dihe-in -76.33, -6.25 -60.23, -17.85 APE12-dist-na 20.462 APE11-dist-na 21.266 APE10-dist-na 19.748 APE9-dist-out 11.525 C488A,C584S None None XRAY 2.193 0.209 0.256 B 317 285 22 0 0 6 [[478, 756]] 1.0 4rwl TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4F65A 464 765 822.0 0S9:808 Type1 Inactive DFGin 5.622 13.08 None -116.38, 166.24 56.16, 50.99 -96.21, 999.0 35.52, 82.62 999.0, 999.0 in-in in 7.976 Saltbr-in 2.925 HRD-in -64.44, -52.01 69.63, -13.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.26, 142.02 APE9-dihe-in -87.5, 110.31 APE8-dihe-out -50.81, -23.5 APE8-rot-na 336.61 APE67-dihe-in -69.73, -13.19 -59.55, -23.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.26 0.204 0.235 A 309 279 23 0 0 10 [[478, 756]] 1.0 4f65 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4NKAB 458 765 822.0 2K7:803 Type1 Inactive DFGin 4.993 12.588 None -113.09, 172.85 51.3, 36.02 -81.11, 999.0 51.02, 79.07 999.0, 999.0 in-in in 7.721 Saltbr-in 2.819 HRD-in -68.57, -53.53 79.69, -21.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -99.94, 158.4 APE9-dihe-in -98.99, 111.75 APE8-dihe-out -53.76, -24.39 APE8-rot-na 331.5 APE67-dihe-in -68.26, -7.43 -55.44, -26.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.424 C488A,C584S None None XRAY 2.19 0.2 0.228 B 309 287 21 0 0 6 [[478, 756]] 1.0 4nka TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4F65B 460 763 822.0 0S9:808 Type1.5_Back Inactive DFGin 6.172 11.744 None -112.37, 28.01 -137.92, 136.63 -123.39, 999.0 315.19, 98.45 999.0, 999.0 in-in in 7.928 Saltbr-in 2.908 HRD-in -72.51, -42.53 62.62, -12.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.78, 143.47 APE9-dihe-in -85.99, 110.74 APE8-dihe-out -51.4, -22.91 APE8-rot-na 337.29 APE67-dihe-in -68.78, -13.01 -59.73, -24.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.257 C488A,C584S None None XRAY 2.26 0.204 0.235 B 309 279 25 0 0 7 [[478, 756]] 1.0 4f65 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6C18B 466 762 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.466 13.156 None -121.52, 157.51 52.39, 50.92 -96.25, 999.0 51.2, 88.67 999.0, 999.0 in-in in 8.023 Saltbr-in 2.924 HRD-in -68.59, -52.77 77.43, -7.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.06 APE8-rot-na 331.63 APE67-dihe-in -71.45, -6.87 -51.83, -28.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 B 311 255 42 0 0 20 [[478, 756]] 1.0 6c18 TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
6MZWB 463 762 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.243 13.191 None -113.61, 162.19 59.99, 41.93 -84.77, 999.0 49.28, 82.5 999.0, 999.0 in-in in 7.816 Saltbr-in 2.684 HRD-in -70.89, -55.55 82.9, -7.56 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-na 29.6 APE67-dihe-in -68.26, -6.41 -48.51, -43.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 B 311 258 42 0 0 20 [[478, 756]] 1.0 6mzw TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4V04B 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.873 BBAminus -127.4, -173.98 -164.99, 120.92 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.015 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.514 APE11-dist-na 20.97 APE10-dist-na 19.298 APE9-dist-out 11.591 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309 289 19 0 0 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4V01A 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.648 9.683 None -136.22, -176.63 -157.46, 111.62 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.852 Saltbr-in 2.824 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.727 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309 273 28 0 0 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4V01B 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.476 9.083 None -140.66, -178.05 -156.06, 123.42 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.916 Saltbr-in 2.807 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.814 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309 275 28 0 0 8 [[478, 756]] 1.0 4v01 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
4V04A 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.051 10.394 None -127.25, -179.24 -145.47, 116.11 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.864 Saltbr-in 3.206 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.639 APE11-dist-na 21.02 APE10-dist-na 19.322 APE9-dist-out 11.7 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309 293 10 0 0 6 [[478, 756]] 1.0 4v04 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

TYR_FGFR1 (Fibroblast growth factor receptor 1)

Total number of chains: 145
Active chains: 3
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 114 78.6% 9UHIA
DFGin BLBplus 11 7.6% 8JQIB
DFGin BLAminus 10 6.9% AF-P11362-K1A
DFGin None 5 3.4% 4NKAB
DFGout None 3 2.1% 4V04A
DFGin BLBminus 1 0.7% 3KXXA
DFGout BBAminus 1 0.7% 4V04B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
FGFR1_HUMAN 3GQIA P11362 464 770 822.0 ACP:775 ATPlike Active DFGin 6.466 13.946 BLAminus -126.61, -175.83 60.19, 72.36 -91.08, 18.42 288.73, 91.63 -64.67, -15.4 in-in in 7.751 Saltbr-in 2.69 HRD-in -77.5, -49.87 72.48, -2.68 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -58.96, 135.34 APE9-dihe-in -149.19, 136.62 APE8-dihe-in -75.51, 66.48 APE8-rot-na 33.4 APE67-dihe-in -65.08, -11.82 -44.91, -41.18 APE12-dist-na 14.083 APE11-dist-na 11.258 APE10-dist-na 10.128 APE9-dist-in 7.137 C488A,Y583F,C584S,Y585F PTR653,PTR654,PTR766 PTR653,PTR654,PTR766 XRAY 2.5 0.249 0.289 A 326 307 0 0 0 0 [[478, 756]] 1.0 3gqi Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN AF-P11362-K1A P11362 470 764 822.0 No_ligand No_ligand Active DFGin 6.585 13.745 BLAminus -135.24, -172.55 53.83, 70.53 -87.91, 10.86 290.57, 95.64 -59.32, -30.75 in-in in 7.453 Saltbr-in 2.648 HRD-in -70.89, -43.2 66.63, -19.06 in-in-in SNCiii in-in ActLoopNT-in 2.9 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.78, 130.17 APE9-dihe-in -137.78, 151.11 APE8-dihe-in -79.35, 77.49 APE8-rot-na 37.15 APE67-dihe-in -67.5, -12.86 -47.07, -41.3 APE12-dist-na 14.394 APE11-dist-na 9.931 APE10-dist-na 9.99 APE9-dist-in 6.506 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[478, 756]] 1.0 AF-P11362-K1 Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN AF-P11362-K3A P11362 470 764 822.0 No_ligand No_ligand Active DFGin 6.146 13.521 BLAminus -139.78, -177.08 59.37, 66.68 -79.98, 12.43 289.81, 96.12 -59.82, -28.59 in-in in 7.906 Saltbr-in 2.659 HRD-in -80.49, -43.82 61.4, -3.43 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -57.53, 136.75 APE9-dihe-in -134.21, 129.98 APE8-dihe-in -82.7, 64.06 APE8-rot-na 35.6 APE67-dihe-in -69.03, -12.46 -46.62, -44.88 APE12-dist-na 13.461 APE11-dist-na 9.794 APE10-dist-na 8.155 APE9-dist-in 6.648 None None None AF2 -1.0 1.0 1.0 A 295 295 0 0 0 0 [[478, 756]] 1.0 AF-P11362-K3 Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3KXXB P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 7.061 14.507 BLAminus -138.91, 177.11 64.42, 63.57 -90.83, 31.94 294.07, 81.15 -71.04, -30.05 in-in in 7.234 Saltbr-in 3.199 HRD-out -89.94, 81.9 -57.82, 5.46 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.01, 74.51 APE9-dihe-in -144.18, 139.02 APE8-dihe-in -51.42, 121.01 APE8-rot-na 327.88 APE67-dihe-in -76.85, -17.4 -68.16, -22.5 APE12-dist-na 14.893 APE11-dist-na 10.36 APE10-dist-na 9.133 APE9-dist-in 5.752 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 B 317 305 0 0 0 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3KXXC P11362 458 762 822.0 No_ligand No_ligand Inactive DFGin 7.139 13.992 BLAminus -138.07, -172.42 62.91, 62.15 -92.81, 13.58 296.2, 98.02 -70.01, -16.73 in-in in 7.243 Saltbr-in 2.637 HRD-out -88.37, 88.38 -55.25, -6.98 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.88, 68.46 APE9-dihe-in -154.11, 147.86 APE8-dihe-in -47.33, 131.68 APE8-rot-na 28.97 APE67-dihe-in -56.58, -13.9 -82.3, -38.63 APE12-dist-na 15.086 APE11-dist-na 10.333 APE10-dist-na 8.947 APE9-dist-in 6.261 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 C 317 286 19 0 0 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3KXXD P11362 458 762 822.0 No_ligand No_ligand Inactive DFGin 6.502 13.671 BLAminus -133.51, -161.48 51.6, 74.09 -99.67, 22.58 293.84, 93.72 -66.62, -32.71 in-in in 7.529 Saltbr-in 3.458 HRD-out -84.43, 73.53 -41.76, -24.93 in-in-in SNCiii in-in ActLoopNT-in 3.114 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.31, 77.29 APE9-dihe-in -147.89, 135.68 APE8-dihe-in -51.4, 116.54 APE8-rot-na 326.12 APE67-dihe-in -63.39, 3.02 -61.34, -39.64 APE12-dist-na 15.473 APE11-dist-na 10.561 APE10-dist-na 8.835 APE9-dist-in 6.24 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 D 317 286 19 0 0 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5FLFA P11362 460 762 822.0 No_ligand No_ligand Inactive DFGin 6.566 13.921 BLAminus -130.07, -173.3 57.53, 81.51 -106.56, 20.58 287.47, 88.65 -65.69, -26.36 in-in in 7.061 Saltbr-in 2.623 HRD-in -77.09, -44.33 71.36, -17.68 in-in-out SNCiio in-out ActLoopNT-in 2.874 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -122.27, 31.65 APE9-dihe-in -120.82, 141.16 APE8-dihe-in -55.6, 118.0 APE8-rot-na 17.74 APE67-dihe-in -68.76, -3.74 -51.76, -42.09 APE12-dist-na 14.969 APE11-dist-na 10.487 APE10-dist-na 8.045 APE9-dist-in 5.76 R675G None None XRAY 2.58 0.197 0.255 A 310 296 7 0 0 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5FLFB P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 6.597 14.271 BLAminus -131.38, -174.56 57.69, 69.98 -91.26, 21.65 284.1, 89.91 -69.58, -18.15 in-in in 7.208 Saltbr-in 2.661 HRD-in -77.24, -42.46 70.08, -13.13 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -119.34, 21.86 APE9-dihe-in -108.05, 143.02 APE8-dihe-in -54.9, 122.45 APE8-rot-na 333.47 APE67-dihe-in -66.56, -8.26 -58.19, -40.45 APE12-dist-na 14.767 APE11-dist-na 10.342 APE10-dist-na 7.676 APE9-dist-in 5.588 R675G None None XRAY 2.58 0.197 0.255 B 310 292 13 0 0 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5FLFC P11362 464 763 822.0 No_ligand No_ligand Inactive DFGin 6.879 14.904 BLAminus -128.63, -179.22 56.68, 76.02 -97.55, 23.96 288.87, 80.23 -64.42, -24.4 in-in in 7.867 Saltbr-in 2.593 HRD-in -77.84, -41.46 68.92, -13.37 in-in-out SNCiio in-out ActLoopNT-in 3.012 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -113.74, 13.42 APE9-dihe-in -108.0, 146.11 APE8-dihe-in -55.87, 118.95 APE8-rot-na 334.41 APE67-dihe-in -77.03, -3.15 -66.33, -25.17 APE12-dist-na 14.723 APE11-dist-na 11.018 APE10-dist-na 8.04 APE9-dist-in 5.535 R675G None None XRAY 2.58 0.197 0.255 C 310 283 17 0 0 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5FLFD P11362 465 763 822.0 No_ligand No_ligand Inactive DFGin 6.563 14.075 BLAminus -137.61, -174.47 56.6, 77.52 -99.56, 24.88 289.94, 80.48 -64.3, -28.41 in-in in 7.277 Saltbr-in 2.824 HRD-in -82.09, -46.03 69.99, -9.21 in-in-out SNCiio in-out ActLoopNT-in 2.934 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -123.36, 26.56 APE9-dihe-in -112.27, 140.35 APE8-dihe-in -53.21, 117.11 APE8-rot-na 330.63 APE67-dihe-in -75.55, -3.28 -53.96, -35.33 APE12-dist-na 14.943 APE11-dist-na 10.506 APE10-dist-na 7.993 APE9-dist-in 5.598 R675G None None XRAY 2.58 0.197 0.255 D 310 290 9 0 0 0 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWIA P11362 460 764 822.0 No_ligand No_ligand Inactive DFGin 5.19 13.287 BLAplus -105.16, 163.21 56.87, 28.19 -74.61, -16.94 54.32, 87.9 -104.05, 11.37 in-in in 7.964 Saltbr-in 2.691 HRD-in -73.3, -52.29 82.32, -10.23 in-out-out SNCioo out-out ActLoopNT-out 8.1 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.29, 144.76 APE9-dihe-in -100.4, 99.63 APE8-dihe-out -55.34, -23.98 APE8-rot-na 331.55 APE67-dihe-in -74.41, -9.61 -59.83, -21.73 APE12-dist-na 17.492 APE11-dist-na 19.033 APE10-dist-na 16.578 APE9-dist-out 11.232 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 A 317 305 0 0 0 0 [[478, 756]] 1.0 4rwi Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWIB P11362 461 763 822.0 No_ligand No_ligand Inactive DFGin 5.141 13.154 BLAplus -106.54, 164.69 57.29, 29.78 -77.53, -18.65 57.49, 89.17 -101.92, 7.65 in-in in 7.879 Saltbr-in 2.87 HRD-in -73.64, -53.72 81.97, -10.53 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.37, 146.39 APE9-dihe-in -96.99, 106.58 APE8-dihe-out -51.08, -23.64 APE8-rot-na 329.78 APE67-dihe-in -74.22, -7.08 -61.58, -21.03 APE12-dist-na 999.0 APE11-dist-na 21.638 APE10-dist-na 19.316 APE9-dist-out 11.632 C488A,V561M,C584S None None XRAY 2.292 0.188 0.236 B 317 280 23 0 0 5 [[478, 756]] 1.0 4rwi Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 1FGKA P11362 464 762 822.0 No_ligand No_ligand Inactive DFGin 5.04 13.153 BLAplus -117.08, 161.77 60.28, 24.85 -72.88, -22.06 56.54, 82.81 -106.67, 14.32 in-in in 7.832 Saltbr-in 3.378 HRD-in -62.23, -53.96 80.79, -13.7 in-out-out SNCioo out-out ActLoopNT-out 8.982 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.16, 160.27 APE9-dihe-in -100.02, 107.51 APE8-dihe-out -50.6, -26.19 APE8-rot-na 325.57 APE67-dihe-in -72.28, -4.51 -59.98, -18.19 APE12-dist-na 19.507 APE11-dist-na 20.666 APE10-dist-na 19.108 APE9-dist-out 11.795 None None None XRAY 2.0 0.213 0.261 A 310 278 21 0 0 0 [[478, 756]] 1.0 1fgk Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 1FGKB P11362 461 761 822.0 No_ligand No_ligand Inactive DFGin 5.192 12.934 BLAplus -119.81, 158.37 63.11, 25.45 -77.92, -15.92 57.79, 81.67 -107.61, 13.08 in-in in 7.691 Saltbr-in 3.032 HRD-in -69.81, -40.78 70.38, -11.69 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.56, 167.66 APE9-dihe-in -110.12, 112.64 APE8-dihe-out -55.04, -21.46 APE8-rot-na 323.57 APE67-dihe-in -69.19, -4.96 -60.35, -22.4 APE12-dist-na 999.0 APE11-dist-na 20.964 APE10-dist-na 19.563 APE9-dist-out 11.572 C488A None None XRAY 2.0 0.213 0.261 B 310 272 29 0 0 9 [[478, 756]] 1.0 1fgk Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4UWYA P11362 462 762 822.0 No_ligand No_ligand Inactive DFGin 5.291 12.863 BLAplus -108.05, 160.93 49.5, 43.38 -87.31, -20.81 54.11, 89.18 -97.03, 5.71 in-in in 7.508 Saltbr-in 2.443 HRD-in -75.4, -42.68 70.46, -5.54 in-out-out SNCioo out-out ActLoopNT-out 7.659 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -82.93, 150.1 APE9-dihe-in -108.91, 96.97 APE8-dihe-out -51.49, -30.02 APE8-rot-na 332.53 APE67-dihe-in -69.11, -13.52 -51.63, -33.68 APE12-dist-na 16.731 APE11-dist-na 19.192 APE10-dist-na 16.474 APE9-dist-out 11.016 None None None XRAY 2.305 0.214 0.267 A 310 296 5 0 0 0 [[478, 756]] 1.0 4uwy Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4UWYB P11362 459 762 822.0 No_ligand No_ligand Inactive DFGin 5.113 12.787 BLAplus -107.94, 162.87 51.01, 42.84 -88.14, -19.95 53.77, 88.06 -94.96, 5.78 in-in in 7.418 Saltbr-in 2.548 HRD-in -75.22, -44.02 71.63, -5.56 in-out-out SNCioo out-out ActLoopNT-out 7.722 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.53 APE8-dihe-out -53.14, -29.69 APE8-rot-na 332.32 APE67-dihe-in -67.22, -11.8 -51.66, -31.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.733 None None None XRAY 2.305 0.214 0.267 B 310 273 31 0 0 14 [[478, 756]] 1.0 4uwy Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3KY2A P11362 458 764 822.0 No_ligand No_ligand Inactive DFGin 5.142 13.303 BLAplus -122.69, 172.32 46.54, 42.6 -95.25, -13.81 55.54, 83.43 -110.08, 21.37 in-in in 7.983 Saltbr-in 2.704 HRD-in -54.04, -52.31 78.54, -4.33 in-out-out SNCioo out-out ActLoopNT-out 7.905 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.74, 144.51 APE9-dihe-in -109.2, 106.89 APE8-dihe-out -56.11, -24.62 APE8-rot-na 329.61 APE67-dihe-in -74.45, -13.88 -60.05, -25.51 APE12-dist-na 17.026 APE11-dist-na 19.618 APE10-dist-na 16.611 APE9-dist-out 11.139 C488A,C584S None None XRAY 2.7 0.206 0.252 A 317 305 2 0 0 0 [[478, 756]] 1.0 3ky2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3KY2B P11362 460 763 822.0 No_ligand No_ligand Inactive DFGin 5.306 13.131 BLAplus -120.14, 165.15 53.12, 37.21 -90.32, -21.71 57.04, 89.19 -96.69, 4.05 in-in in 7.75 Saltbr-in 2.873 HRD-in -63.32, -45.74 74.66, -3.4 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.35, 149.7 APE9-dihe-in -86.12, 120.09 APE8-dihe-out -58.71, -15.12 APE8-rot-na 326.3 APE67-dihe-in -64.29, -14.63 -68.37, -29.74 APE12-dist-na 19.93 APE11-dist-na 21.279 APE10-dist-na 19.838 APE9-dist-out 11.793 C488A,C584S None None XRAY 2.7 0.206 0.252 B 317 280 24 0 0 6 [[478, 756]] 1.0 3ky2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWLA P11362 465 765 822.0 No_ligand No_ligand Inactive DFGin 5.26 13.19 BLAplus -120.07, 160.93 64.42, 29.27 -80.33, -20.1 51.65, 89.33 -96.98, 0.13 in-in in 7.774 Saltbr-in 2.904 HRD-in -75.31, -52.96 79.05, -10.93 in-out-out SNCioo out-out ActLoopNT-out 8.242 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.23, 163.46 APE9-dihe-in -103.38, 113.99 APE8-dihe-out -51.08, -26.28 APE8-rot-na 327.94 APE67-dihe-in -75.8, -7.21 -59.7, -19.52 APE12-dist-na 19.715 APE11-dist-na 21.18 APE10-dist-na 19.602 APE9-dist-out 11.603 C488A,C584S None None XRAY 2.193 0.209 0.256 A 317 282 19 0 0 3 [[478, 756]] 1.0 4rwl Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5FLFE P11362 466 761 822.0 No_ligand No_ligand Inactive DFGin 5.857 13.333 BLAplus -107.08, 156.12 59.3, 89.04 -145.68, 9.21 46.94, 85.34 -107.07, -8.42 in-out in 7.681 Saltbr-out 4.122 HRD-in -76.44, -47.72 79.39, -32.07 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -134.53, 84.16 APE9-dihe-out 70.54, 76.98 APE8-dihe-out -73.71, -15.89 APE8-rot-na 29.38 APE67-dihe-in -66.59, -10.19 -60.2, -29.73 APE12-dist-na 999.0 APE11-dist-na 15.329 APE10-dist-na 19.628 APE9-dist-out 11.396 R675G None None XRAY 2.58 0.197 0.255 E 310 258 38 0 0 14 [[478, 756]] 1.0 5flf Homo sapiens TYR_FGFR1_HUMAN TYR 2.7e-104 354.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5AM7A P11362 458 764 822.0 38O:1000 Type1 Inactive DFGin 5.322 13.404 BLAplus -119.96, 160.03 61.93, 31.32 -78.06, -16.68 51.95, 91.0 -102.88, 8.06 in-in in 7.784 Saltbr-in 2.821 HRD-in -72.13, -53.65 81.66, -13.87 in-out-out SNCioo out-out ActLoopNT-out 8.844 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.07, 161.69 APE9-dihe-in -97.7, 110.93 APE8-dihe-out -50.41, -28.65 APE8-rot-na 335.18 APE67-dihe-in -73.88, -5.16 -55.74, -23.35 APE12-dist-na 19.89 APE11-dist-na 21.192 APE10-dist-na 19.934 APE9-dist-out 11.887 V561M None None XRAY 1.957 0.201 0.254 A 310 294 13 0 0 0 [[478, 756]] 1.0 5am7 Homo sapiens TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5AM7B P11362 458 762 822.0 38O:1000 Type1 Inactive DFGin 5.351 13.056 BLAplus -118.51, 161.73 60.87, 31.35 -81.93, -17.68 51.44, 85.63 -98.47, 10.33 in-in in 7.879 Saltbr-in 3.092 HRD-in -70.81, -53.93 79.14, -12.6 in-out-out SNCioo out-out ActLoopNT-out 8.493 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.26, 167.43 APE9-dihe-in -92.91, 111.75 APE8-dihe-out -51.15, -27.96 APE8-rot-na 332.74 APE67-dihe-in -72.49, -4.42 -56.51, -22.72 APE12-dist-na 19.29 APE11-dist-na 21.059 APE10-dist-na 19.935 APE9-dist-out 11.772 V561M None None XRAY 1.957 0.201 0.254 B 310 287 18 0 0 5 [[478, 756]] 1.0 5am7 Homo sapiens TYR_FGFR1_HUMAN TYR 7.7e-105 355.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWKA P11362 458 764 822.0 66T:60801 Type1 Inactive DFGin 5.334 13.448 BLAplus -119.61, 171.78 43.5, 42.06 -91.27, -13.97 55.41, 85.99 -97.85, 1.35 in-in in 8.3 Saltbr-in 2.858 HRD-in -72.97, -43.98 66.64, 7.94 in-out-out SNCioo out-out ActLoopNT-out 7.612 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -132.9, 130.16 APE9-dihe-in -81.93, 117.68 APE8-dihe-out -73.74, -2.4 APE8-rot-na 340.19 APE67-dihe-in -78.12, -6.2 -84.98, -15.3 APE12-dist-na 17.009 APE11-dist-na 18.951 APE10-dist-na 16.709 APE9-dist-out 11.004 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 A 317 307 0 0 0 0 [[478, 756]] 1.0 4rwk Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4ZSAA P11362 464 765 822.0 4UT:801 Type1 Inactive DFGin 5.236 13.358 BLAplus -116.62, 164.17 62.61, 38.9 -97.55, -0.8 57.69, 84.31 -93.9, -12.07 in-in in 7.727 Saltbr-in 3.074 HRD-in -75.4, -51.03 78.41, -18.38 in-out-out SNCioo out-out ActLoopNT-out 7.801 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.19, 166.07 APE9-dihe-in -106.61, 111.7 APE8-dihe-out -53.66, -24.02 APE8-rot-na 328.26 APE67-dihe-in -75.2, -3.02 -58.56, -21.55 APE12-dist-na 20.997 APE11-dist-na 22.32 APE10-dist-na 20.795 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.0 0.206 0.254 A 308 290 12 0 0 0 [[478, 756]] 1.0 4zsa Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4ZSAB P11362 462 761 822.0 4UT:801 Type1 Inactive DFGin 5.378 12.914 BLAplus -118.54, 160.55 64.46, 37.46 -95.07, -9.43 54.72, 89.6 -73.6, -19.27 in-in in 7.641 Saltbr-in 3.163 HRD-in -75.52, -45.77 74.73, -25.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.36, 172.16 APE9-dihe-in -104.52, 114.27 APE8-dihe-out -53.39, -26.0 APE8-rot-na 330.81 APE67-dihe-in -73.62, -3.9 -59.13, -21.5 APE12-dist-na 20.725 APE11-dist-na 22.162 APE10-dist-na 20.859 APE9-dist-out 11.525 C488A,C584S None None XRAY 2.0 0.206 0.254 B 308 282 18 0 0 6 [[478, 756]] 1.0 4zsa Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5Z0SA P11362 464 762 822.0 960:801 Type1 Inactive DFGin 5.126 13.601 BLAplus -107.75, 154.51 67.56, 21.06 -67.0, -16.05 58.84, 83.24 -104.7, 10.76 in-in in 8.094 Saltbr-in 2.743 HRD-in -68.85, -52.46 79.64, -4.73 in-out-out SNCioo out-out ActLoopNT-out 8.709 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -91.28, 165.51 APE9-dihe-in -109.21, 113.36 APE8-dihe-out -56.28, -24.44 APE8-rot-na 329.92 APE67-dihe-in -71.21, -1.87 -54.7, -23.75 APE12-dist-na 19.955 APE11-dist-na 21.515 APE10-dist-na 19.768 APE9-dist-out 11.976 C488A,C584S None None XRAY 2.45 0.227 0.275 A 308 285 14 0 0 0 [[478, 756]] 1.0 5z0s Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5Z0SB P11362 464 761 822.0 960:801 Type1 Inactive DFGin 5.197 13.43 BLAplus -118.1, 161.06 54.97, 27.99 -69.34, -31.76 53.53, 89.4 -87.91, 8.99 in-in in 7.946 Saltbr-in 2.979 HRD-in -70.36, -53.32 74.41, -8.98 in-out-out SNCioo out-out ActLoopNT-out 8.874 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.22, 166.31 APE9-dihe-in -107.5, 114.63 APE8-dihe-out -57.82, -27.73 APE8-rot-na 335.53 APE67-dihe-in -71.06, -7.47 -49.72, -27.2 APE12-dist-na 19.592 APE11-dist-na 21.39 APE10-dist-na 19.783 APE9-dist-out 11.761 C488A,C584S None None XRAY 2.45 0.227 0.275 B 308 281 17 0 0 1 [[478, 756]] 1.0 5z0s Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6ITJA P11362 464 765 822.0 AXU:801 Type1 Inactive DFGin 5.03 13.791 BLAplus -109.33, 156.39 67.34, 25.69 -70.89, -16.74 55.89, 87.5 -104.45, 10.23 in-in in 8.034 Saltbr-in 2.757 HRD-in -71.81, -52.98 81.18, -14.83 in-out-out SNCioo out-out ActLoopNT-out 8.717 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.06, 160.2 APE9-dihe-in -100.03, 111.11 APE8-dihe-out -53.01, -25.62 APE8-rot-na 330.27 APE67-dihe-in -75.62, -3.59 -58.81, -16.58 APE12-dist-na 19.46 APE11-dist-na 21.02 APE10-dist-na 19.465 APE9-dist-out 11.773 C488A,C584S None None XRAY 1.994 0.201 0.244 A 308 290 12 0 0 0 [[478, 756]] 1.0 6itj Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6ITJB P11362 459 761 822.0 AXU:801 Type1 Inactive DFGin 5.279 13.661 BLAplus -115.06, 158.21 61.95, 30.4 -73.56, -20.55 53.39, 86.78 -101.45, 8.81 in-in in 7.858 Saltbr-in 2.784 HRD-in -74.1, -50.66 79.66, -17.24 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.82, 164.92 APE9-dihe-in -97.18, 112.3 APE8-dihe-out -56.27, -24.59 APE8-rot-na 332.48 APE67-dihe-in -69.44, -5.6 -58.71, -22.22 APE12-dist-na 19.468 APE11-dist-na 21.022 APE10-dist-na 19.807 APE9-dist-out 11.652 C488A,C584S None None XRAY 1.994 0.201 0.244 B 308 293 10 0 0 5 [[478, 756]] 1.0 6itj Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 9CD5A P11362 465 764 822.0 A1AV2:903 Type1 Inactive DFGin 5.109 13.041 BLAplus -119.69, 171.16 42.37, 48.64 -93.51, -18.78 55.6, 81.67 -108.27, 19.83 in-in in 7.642 Saltbr-in 3.4 HRD-in -70.51, -58.43 92.5, -15.84 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -123.63, 147.65 APE9-dihe-in -93.38, 113.67 APE8-dihe-out -55.42, -20.8 APE8-rot-na 334.26 APE67-dihe-in -78.47, -7.11 -58.87, -20.29 APE12-dist-na 21.398 APE11-dist-na 21.238 APE10-dist-na 19.52 APE9-dist-out 11.608 C488A,C584S None None XRAY 2.939 0.215 0.263 A 308 281 19 0 0 6 [[478, 756]] 1.0 9cd5 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 9CD5B P11362 460 764 822.0 A1AV2:902 Type1 Inactive DFGin 5.112 12.776 BLAplus -119.68, 169.96 44.78, 47.92 -93.2, -18.16 54.47, 80.79 -103.83, 15.64 in-in in 7.59 Saltbr-in 3.242 HRD-in -70.44, -57.93 92.25, -15.3 in-out-out SNCioo out-out ActLoopNT-out 7.979 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.57, 148.55 APE9-dihe-in -93.36, 113.84 APE8-dihe-out -53.62, -20.73 APE8-rot-na 332.43 APE67-dihe-in -77.99, -7.05 -59.24, -19.94 APE12-dist-na 21.01 APE11-dist-na 20.993 APE10-dist-na 19.181 APE9-dist-out 11.584 C488A,C584S None None XRAY 2.939 0.215 0.263 B 308 289 16 0 0 2 [[478, 756]] 1.0 9cd5 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4F63A P11362 464 762 822.0 0S7:801 Type1 Inactive DFGin 5.272 13.227 BLAplus -123.63, 158.75 70.08, 13.43 -68.79, -20.53 59.97, 88.79 -95.8, 8.85 in-in in 7.524 Saltbr-in 3.232 HRD-in -74.6, -50.94 76.01, -22.74 in-out-out SNCioo out-out ActLoopNT-out 8.974 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -83.88, 159.94 APE9-dihe-in -104.27, 121.64 APE8-dihe-out -54.29, -35.97 APE8-rot-na 333.58 APE67-dihe-in -71.9, -7.89 -48.05, -24.06 APE12-dist-na 19.824 APE11-dist-na 21.294 APE10-dist-na 19.49 APE9-dist-out 11.802 C488A,C584S None None XRAY 2.55 0.232 0.287 A 309 278 21 0 0 0 [[478, 756]] 1.0 4f63 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4F63B P11362 461 761 822.0 0S7:801 Type1 Inactive DFGin 5.107 12.59 BLAplus -103.1, 171.09 57.7, 19.47 -72.81, -17.05 60.59, 83.16 -102.04, 8.53 in-none in 7.731 Saltbr-none 999.0 HRD-in -67.88, -51.25 73.72, -23.66 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.49, 174.14 APE9-dihe-in -102.48, 111.01 APE8-dihe-out -53.24, -29.21 APE8-rot-na 329.82 APE67-dihe-in -68.76, -1.69 -49.63, -27.49 APE12-dist-na 999.0 APE11-dist-na 20.78 APE10-dist-na 19.771 APE9-dist-out 11.499 C488A,C584S None None XRAY 2.55 0.232 0.287 B 309 271 30 0 0 9 [[478, 756]] 1.0 4f63 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4F64A P11362 464 762 822.0 0S8:801 Type1 Inactive DFGin 5.183 13.118 BLAplus -126.63, 159.8 67.66, 19.43 -73.38, -15.37 61.14, 82.05 -112.05, 14.31 in-in in 7.833 Saltbr-in 2.657 HRD-in -75.01, -53.26 79.37, -13.8 in-out-out SNCioo out-out ActLoopNT-out 8.889 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.36, 162.32 APE9-dihe-in -110.59, 112.62 APE8-dihe-out -54.21, -21.82 APE8-rot-na 334.94 APE67-dihe-in -73.68, -4.51 -58.01, -22.74 APE12-dist-na 19.925 APE11-dist-na 21.624 APE10-dist-na 19.607 APE9-dist-out 11.74 C488A,C584S None None XRAY 2.05 0.217 0.269 A 309 278 21 0 0 0 [[478, 756]] 1.0 4f64 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4F64B P11362 461 761 822.0 0S8:801 Type1 Inactive DFGin 5.167 12.905 BLAplus -128.73, 164.19 64.4, 29.6 -84.21, -15.05 59.33, 82.94 -106.3, 1.28 in-in in 7.894 Saltbr-in 2.864 HRD-in -73.33, -50.22 71.98, 0.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.2, 170.72 APE9-dihe-in -106.18, 108.15 APE8-dihe-out -52.36, -27.43 APE8-rot-na 328.0 APE67-dihe-in -80.92, -6.4 -55.61, -16.72 APE12-dist-na 999.0 APE11-dist-na 20.995 APE10-dist-na 19.853 APE9-dist-out 11.556 C488A,C584S None None XRAY 2.05 0.217 0.269 B 309 272 29 0 0 9 [[478, 756]] 1.0 4f64 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4NKAA P11362 464 765 822.0 2K7:805 Type1 Inactive DFGin 5.46 12.83 BLAplus -109.75, 172.82 48.9, 35.6 -81.04, -25.72 46.07, 87.87 -114.73, 999.0 in-none in 7.756 Saltbr-none 999.0 HRD-in -68.09, -53.27 80.47, -22.49 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.83, 157.85 APE9-dihe-in -101.57, 110.94 APE8-dihe-out -54.92, -24.59 APE8-rot-na 334.91 APE67-dihe-in -67.94, -8.42 -53.61, -27.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.57 C488A,C584S None None XRAY 2.19 0.2 0.228 A 309 279 23 0 0 7 [[478, 756]] 1.0 4nka Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4NKSA P11362 465 762 822.0 2M2:801 Type1 Inactive DFGin 5.63 13.809 BLAplus -128.87, 161.68 65.74, 29.25 -87.1, -15.4 56.23, 91.24 -92.95, -7.65 in-in in 7.896 Saltbr-in 3.034 HRD-in -61.09, -57.02 76.92, -17.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.5, 152.38 APE9-dihe-in -96.93, 124.37 APE8-dihe-out -60.38, -26.39 APE8-rot-na 339.01 APE67-dihe-in -76.01, -5.61 -56.44, -21.34 APE12-dist-na 20.012 APE11-dist-na 21.72 APE10-dist-na 19.688 APE9-dist-out 11.709 C488A,C584S None None XRAY 2.5 0.223 0.278 A 309 265 33 0 0 6 [[478, 756]] 1.0 4nks Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4NKSB P11362 461 761 822.0 2M2:801 Type1 Inactive DFGin 5.47 13.082 BLAplus -121.26, 176.2 65.04, 19.79 -85.17, -9.87 56.43, 80.08 -103.8, -4.05 in-in in 7.809 Saltbr-in 3.228 HRD-in -66.41, -53.36 81.34, -22.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -109.88, 166.85 APE9-dihe-in -99.02, 113.91 APE8-dihe-out -58.98, -23.63 APE8-rot-na 332.76 APE67-dihe-in -64.8, 1.58 -54.87, -32.1 APE12-dist-na 999.0 APE11-dist-na 20.725 APE10-dist-na 19.536 APE9-dist-out 11.727 C488A,C584S None None XRAY 2.5 0.223 0.278 B 309 271 30 0 0 9 [[478, 756]] 1.0 4nks Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4UWBA P11362 464 765 822.0 JVT:1769 Type1 Inactive DFGin 5.316 13.299 BLAplus -113.09, 161.83 71.69, 23.97 -88.05, -18.23 56.26, 82.28 -95.96, 11.67 in-in in 7.873 Saltbr-in 2.725 HRD-in -67.29, -55.31 79.69, -18.23 in-out-out SNCioo out-out ActLoopNT-out 8.961 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 154.4 APE9-dihe-in -93.53, 118.15 APE8-dihe-out -56.85, -29.21 APE8-rot-na 332.74 APE67-dihe-in -81.26, -7.02 -49.23, -21.08 APE12-dist-na 19.692 APE11-dist-na 21.382 APE10-dist-na 19.606 APE9-dist-out 11.781 C488A,C584S None None XRAY 2.31 0.231 0.272 A 309 299 3 0 0 1 [[478, 756]] 1.0 4uwb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4UWBB P11362 459 765 822.0 JVT:1768 Type1 Inactive DFGin 5.437 13.03 BLAplus -114.82, 162.53 65.13, 21.85 -74.05, -17.91 55.13, 90.89 -100.48, 4.93 in-in in 7.888 Saltbr-in 2.708 HRD-in -76.21, -52.64 84.1, -25.36 in-out-out SNCioo out-out ActLoopNT-out 7.933 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.09, 162.16 APE9-dihe-in -103.08, 113.2 APE8-dihe-out -55.06, -17.49 APE8-rot-na 323.82 APE67-dihe-in -71.23, -5.74 -60.29, -25.5 APE12-dist-na 20.005 APE11-dist-na 21.388 APE10-dist-na 19.897 APE9-dist-out 11.597 C488A,C584S None None XRAY 2.31 0.231 0.272 B 309 299 8 0 0 3 [[478, 756]] 1.0 4uwb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4UWCA P11362 465 765 822.0 4Y0:1773 Type1 Inactive DFGin 5.185 13.218 BLAplus -114.28, 167.51 64.08, 17.08 -73.37, -20.76 56.56, 86.09 -95.43, 0.2 in-in in 7.666 Saltbr-in 2.769 HRD-in -68.21, -55.41 81.81, -19.33 in-out-out SNCioo out-out ActLoopNT-out 8.009 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.15, 154.48 APE9-dihe-in -99.31, 111.29 APE8-dihe-out -53.23, -22.86 APE8-rot-na 338.31 APE67-dihe-in -68.82, -8.72 -56.37, -24.16 APE12-dist-na 20.301 APE11-dist-na 21.198 APE10-dist-na 19.379 APE9-dist-out 11.757 C488A,C584S None None XRAY 1.96 0.179 0.206 A 309 301 0 0 0 0 [[478, 756]] 1.0 4uwc Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4UWCB P11362 459 764 822.0 4Y0:1770 Type1 Inactive DFGin 5.22 13.022 BLAplus -114.0, 163.28 67.1, 18.57 -73.54, -21.45 56.42, 85.19 -95.52, -0.76 in-in in 7.59 Saltbr-in 2.92 HRD-in -68.93, -54.08 82.79, -14.74 in-out-out SNCioo out-out ActLoopNT-out 8.343 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.38, 156.7 APE9-dihe-in -100.76, 111.03 APE8-dihe-out -54.68, -24.33 APE8-rot-na 334.31 APE67-dihe-in -64.61, -11.0 -54.66, -28.32 APE12-dist-na 20.088 APE11-dist-na 21.147 APE10-dist-na 19.481 APE9-dist-out 11.733 C488A,C584S None None XRAY 1.96 0.179 0.206 B 309 301 5 0 0 0 [[478, 756]] 1.0 4uwc Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5O49A P11362 464 764 822.0 9K5:801 Type1 Inactive DFGin 5.24 13.638 BLAplus -124.98, 161.58 68.85, 20.17 -74.75, -11.05 61.69, 77.84 -110.93, 4.69 in-out in 8.125 Saltbr-out 5.546 HRD-in -64.73, -48.02 76.28, -6.18 out-out-out SNCooo out-out ActLoopNT-out 8.782 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.25, 168.76 APE9-dihe-in -119.19, 119.01 APE8-dihe-out -64.8, -20.97 APE8-rot-na 343.93 APE67-dihe-in -73.72, -10.74 -55.47, -23.05 APE12-dist-na 19.565 APE11-dist-na 21.14 APE10-dist-na 19.5 APE9-dist-out 11.833 C488A,C584S None None XRAY 1.91 0.2 0.22 A 309 289 12 0 0 0 [[478, 756]] 1.0 5o49 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5O49B P11362 460 765 822.0 9K5:801 Type1 Inactive DFGin 5.619 12.929 BLAplus -126.58, 172.58 67.38, 24.13 -84.06, -18.33 50.82, 87.05 -104.51, 13.86 in-out in 7.638 Saltbr-out 4.5 HRD-in -61.81, -47.66 75.62, -5.93 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.43, 163.49 APE9-dihe-in -105.31, 114.78 APE8-dihe-out -56.47, -25.97 APE8-rot-na 333.8 APE67-dihe-in -70.86, -8.05 -56.14, -23.8 APE12-dist-na 19.012 APE11-dist-na 20.412 APE10-dist-na 18.787 APE9-dist-out 11.723 C488A,C584S None None XRAY 1.91 0.2 0.22 B 309 286 20 0 0 5 [[478, 756]] 1.0 5o49 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5O4AA P11362 464 764 822.0 9K8:804 Type1 Inactive DFGin 5.412 13.545 BLAplus -122.09, 166.75 52.86, 39.44 -89.66, -24.51 52.16, 85.77 -93.11, 3.02 in-out in 7.921 Saltbr-out 5.707 HRD-in -69.28, -47.39 73.72, -11.63 out-out-out SNCooo out-out ActLoopNT-out 8.755 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.02, 156.72 APE9-dihe-in -102.28, 120.59 APE8-dihe-out -56.89, -30.5 APE8-rot-na 333.66 APE67-dihe-in -72.75, -8.94 -55.59, -20.78 APE12-dist-na 20.084 APE11-dist-na 21.459 APE10-dist-na 19.653 APE9-dist-out 11.899 None None None XRAY 2.01 0.217 0.225 A 309 290 11 0 0 0 [[478, 756]] 1.0 5o4a Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5O4AB P11362 460 763 822.0 9K8:802 Type1 Inactive DFGin 5.521 13.094 BLAplus -119.73, 164.81 56.03, 47.68 -94.68, -27.26 47.68, 87.08 -89.69, 6.98 in-out in 7.734 Saltbr-out 4.109 HRD-in -64.38, -47.45 77.25, -12.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.24, 154.27 APE9-dihe-in -101.59, 121.81 APE8-dihe-out -57.48, -31.39 APE8-rot-na 330.82 APE67-dihe-in -66.62, 0.37 -53.02, -29.01 APE12-dist-na 20.018 APE11-dist-na 21.049 APE10-dist-na 19.102 APE9-dist-out 11.703 None None None XRAY 2.01 0.217 0.225 B 309 291 13 0 0 5 [[478, 756]] 1.0 5o4a Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7OZBAAA P11362 464 765 822.0 47I:801 Type1 Inactive DFGin 5.165 13.226 BLAplus -113.5, 164.02 64.24, 28.44 -81.1, -17.3 55.31, 86.35 -99.81, -4.02 in-in in 7.678 Saltbr-in 3.035 HRD-in -68.22, -55.33 81.75, -15.47 in-out-out SNCioo out-out ActLoopNT-out 8.629 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.53, 159.74 APE9-dihe-in -101.43, 112.26 APE8-dihe-out -54.35, -25.93 APE8-rot-na 332.55 APE67-dihe-in -70.65, -7.52 -55.15, -25.11 APE12-dist-na 19.292 APE11-dist-na 20.745 APE10-dist-na 19.195 APE9-dist-out 11.664 C488A,C584S None None XRAY 1.71 0.211 0.244 AAA 309 288 14 0 0 0 [[478, 756]] 1.0 7ozb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7OZBBBB P11362 460 764 822.0 47I:801 Type1 Inactive DFGin 5.22 12.853 BLAplus -116.55, 158.6 67.07, 25.64 -79.35, -20.91 57.12, 84.44 -89.98, -6.37 in-in in 7.631 Saltbr-in 2.983 HRD-in -68.5, -59.33 86.86, -18.0 in-out-out SNCioo out-out ActLoopNT-out 8.193 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.69, 159.38 APE9-dihe-in -99.92, 110.92 APE8-dihe-out -56.91, -22.49 APE8-rot-na 333.27 APE67-dihe-in -69.35, -9.22 -56.3, -24.07 APE12-dist-na 19.557 APE11-dist-na 20.901 APE10-dist-na 19.32 APE9-dist-out 11.557 C488A,C584S None None XRAY 1.71 0.211 0.244 BBB 309 291 14 0 0 0 [[478, 756]] 1.0 7ozb Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7OZDAAA P11362 464 765 822.0 42I:801 Type1 Inactive DFGin 5.189 13.322 BLAplus -116.42, 163.08 62.72, 27.25 -80.95, -15.5 58.36, 83.15 -93.3, -6.95 in-in in 7.699 Saltbr-in 2.885 HRD-in -70.31, -57.17 82.73, -17.12 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.1, 157.43 APE9-dihe-in -99.3, 111.88 APE8-dihe-out -57.0, -23.76 APE8-rot-na 335.77 APE67-dihe-in -73.24, -6.2 -56.45, -22.92 APE12-dist-na 20.067 APE11-dist-na 21.455 APE10-dist-na 19.818 APE9-dist-out 11.756 C488A,C584S None None XRAY 1.82 0.201 0.241 AAA 309 282 20 0 0 6 [[478, 756]] 1.0 7ozd Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7OZDBBB P11362 460 763 822.0 42I:801 Type1 Inactive DFGin 5.218 12.867 BLAplus -120.15, 162.48 66.77, 26.73 -83.0, -17.85 57.88, 82.23 -92.89, -7.69 in-in in 7.547 Saltbr-in 2.97 HRD-in -73.06, -57.3 87.17, -16.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -111.05, 157.78 APE9-dihe-in -98.55, 112.28 APE8-dihe-out -56.64, -24.18 APE8-rot-na 331.82 APE67-dihe-in -72.02, -11.22 -53.55, -23.65 APE12-dist-na 19.616 APE11-dist-na 20.938 APE10-dist-na 19.366 APE9-dist-out 11.599 C488A,C584S None None XRAY 1.82 0.201 0.241 BBB 309 285 19 0 0 5 [[478, 756]] 1.0 7ozd Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7OZFAAA P11362 465 765 822.0 466:801 Type1 Inactive DFGin 5.295 13.468 BLAplus -117.68, 161.62 66.46, 36.41 -95.38, -7.29 57.95, 82.09 -95.91, -11.26 in-in in 7.802 Saltbr-in 3.034 HRD-in -74.16, -54.6 82.1, -14.72 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.26, 162.73 APE9-dihe-in -101.57, 112.99 APE8-dihe-out -53.92, -25.84 APE8-rot-na 335.55 APE67-dihe-in -73.42, -8.15 -56.91, -22.71 APE12-dist-na 20.334 APE11-dist-na 21.678 APE10-dist-na 20.2 APE9-dist-out 11.727 None None None XRAY 1.82 0.206 0.242 AAA 309 288 13 0 0 5 [[478, 756]] 1.0 7ozf Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7OZFBBB P11362 460 763 822.0 466:801 Type1 Inactive DFGin 5.253 13.023 BLAplus -116.0, 158.26 69.37, 33.48 -90.88, -17.29 57.42, 83.97 -77.99, -12.47 in-in in 7.643 Saltbr-in 2.966 HRD-in -73.91, -57.88 84.04, -15.02 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.71, 160.57 APE9-dihe-in -98.6, 110.79 APE8-dihe-out -55.8, -24.65 APE8-rot-na 332.84 APE67-dihe-in -74.09, -8.17 -55.72, -20.54 APE12-dist-na 20.458 APE11-dist-na 21.859 APE10-dist-na 20.178 APE9-dist-out 11.652 None None None XRAY 1.82 0.206 0.242 BBB 309 282 22 0 0 5 [[478, 756]] 1.0 7ozf Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 1AGWA P11362 464 762 822.0 SU2:1001 Type1 Inactive DFGin 5.274 13.389 BLAplus -121.22, 164.09 62.54, 22.82 -75.41, -18.74 57.89, 80.74 -105.07, 9.46 in-out in 7.71 Saltbr-out 3.845 HRD-in -69.09, -52.68 78.93, -10.47 out-out-out SNCooo out-out ActLoopNT-out 9.072 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.44, 164.07 APE9-dihe-in -103.49, 105.01 APE8-dihe-out -48.23, -28.22 APE8-rot-na 326.86 APE67-dihe-in -79.1, -0.7 -60.74, -14.06 APE12-dist-na 19.71 APE11-dist-na 20.873 APE10-dist-na 19.257 APE9-dist-out 11.903 None None None XRAY 2.4 0.194 0.28 A 310 278 21 0 0 0 [[478, 756]] 1.0 1agw Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 1AGWB P11362 461 761 822.0 SU2:1000 Type1 Inactive DFGin 5.105 12.927 BLAplus -118.48, 160.09 61.53, 23.36 -75.62, -9.51 55.77, 89.71 -113.95, 12.53 in-in in 7.774 Saltbr-in 2.974 HRD-in -65.85, -35.14 62.11, -1.91 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.88, 159.91 APE9-dihe-in -102.85, 114.8 APE8-dihe-out -54.83, -28.49 APE8-rot-na 327.14 APE67-dihe-in -71.12, -9.61 -53.83, -20.83 APE12-dist-na 999.0 APE11-dist-na 21.087 APE10-dist-na 19.559 APE9-dist-out 11.794 C488A None None XRAY 2.4 0.194 0.28 B 310 272 29 0 0 9 [[478, 756]] 1.0 1agw Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 1FGIA P11362 464 762 822.0 SU1:1001 Type1 Inactive DFGin 5.245 13.051 BLAplus -118.43, 166.43 66.52, 8.73 -64.13, -34.61 60.57, 85.04 -94.1, 14.31 in-out in 7.81 Saltbr-out 4.394 HRD-in -65.25, -56.3 86.33, -6.46 out-out-out SNCooo out-out ActLoopNT-out 9.019 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.01, 168.11 APE9-dihe-in -109.23, 108.22 APE8-dihe-out -49.03, -28.53 APE8-rot-na 326.13 APE67-dihe-in -78.81, -8.46 -60.3, -12.78 APE12-dist-na 19.401 APE11-dist-na 20.922 APE10-dist-na 19.213 APE9-dist-out 11.74 C488A None None XRAY 2.5 0.19 0.27 A 310 283 16 0 0 0 [[478, 756]] 1.0 1fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 1FGIB P11362 461 761 822.0 SU1:1000 Type1 Inactive DFGin 5.085 12.887 BLAplus -129.12, 161.76 68.96, 4.34 -61.61, -28.72 62.68, 83.75 -98.14, 18.47 in-in in 7.977 Saltbr-in 3.237 HRD-in -67.23, -42.86 65.67, 6.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.03, 163.6 APE9-dihe-in -107.58, 116.43 APE8-dihe-out -54.66, -25.86 APE8-rot-na 323.83 APE67-dihe-in -66.67, -9.45 -56.63, -25.45 APE12-dist-na 999.0 APE11-dist-na 21.117 APE10-dist-na 19.557 APE9-dist-out 11.785 C488A None None XRAY 2.5 0.19 0.27 B 310 272 29 0 0 9 [[478, 756]] 1.0 1fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5AM6A P11362 458 765 822.0 38O:61766 Type1 Inactive DFGin 5.201 13.27 BLAplus -112.58, 159.52 61.38, 32.49 -78.96, -18.15 54.05, 84.03 -102.14, 12.3 in-in in 7.715 Saltbr-in 3.252 HRD-in -73.83, -55.77 84.43, -16.37 in-out-out SNCioo out-out ActLoopNT-out 8.728 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.68, 158.35 APE9-dihe-in -101.09, 116.06 APE8-dihe-out -55.18, -24.78 APE8-rot-na 339.12 APE67-dihe-in -70.49, -7.18 -57.16, -24.6 APE12-dist-na 19.76 APE11-dist-na 21.181 APE10-dist-na 19.861 APE9-dist-out 11.765 None None None XRAY 1.96 0.216 0.252 A 310 294 14 0 0 0 [[478, 756]] 1.0 5am6 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5AM6B P11362 458 762 822.0 38O:61763 Type1 Inactive DFGin 5.279 13.04 BLAplus -109.26, 159.81 58.35, 42.16 -91.18, -11.81 51.78, 82.49 -107.62, 15.27 in-in in 7.645 Saltbr-in 3.495 HRD-in -73.63, -54.03 80.88, -21.94 in-out-out SNCioo out-out ActLoopNT-out 8.615 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.73, 157.38 APE9-dihe-in -92.88, 109.99 APE8-dihe-out -51.36, -29.92 APE8-rot-na 334.27 APE67-dihe-in -70.82, -6.38 -56.34, -19.57 APE12-dist-na 999.0 APE11-dist-na 21.131 APE10-dist-na 19.744 APE9-dist-out 11.636 None None None XRAY 1.96 0.216 0.252 B 310 280 25 0 0 13 [[478, 756]] 1.0 5am6 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5UQ0A P11362 464 765 822.0 WP1:801 Type1 Inactive DFGin 5.223 13.345 BLAplus -129.51, 154.04 71.7, 22.04 -75.61, 2.54 58.4, 85.52 -125.18, 1.34 in-none in 7.844 Saltbr-none 999.0 HRD-in -67.62, -52.6 81.66, -15.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 93.59 APE8-dihe-out -63.72, -18.01 APE8-rot-na 26.7 APE67-dihe-in -66.9, -7.24 -49.77, -36.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.247 C488A,C584S None None XRAY 2.3 0.237 0.294 A 311 266 36 0 0 17 [[478, 756]] 1.0 5uq0 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5UQ0B P11362 463 762 822.0 WP1:801 Type1 Inactive DFGin 5.252 13.118 BLAplus -135.89, 161.84 57.67, 28.98 -76.93, -27.79 58.9, 86.78 -79.34, -7.22 in-in in 8.18 Saltbr-in 2.638 HRD-in -67.2, -48.58 76.55, -0.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -106.5 APE8-dihe-out -49.01, -32.28 APE8-rot-na 23.14 APE67-dihe-in -80.37, 4.41 -44.32, -39.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.069 C488A,C584S None None XRAY 2.3 0.237 0.294 B 311 256 44 0 0 17 [[478, 756]] 1.0 5uq0 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3JS2A P11362 464 765 822.0 VM1:801 Type1 Inactive DFGin 5.153 13.303 BLAplus -121.66, 167.26 60.21, 27.33 -82.6, -17.8 54.2, 84.02 -103.88, 10.59 in-in in 7.724 Saltbr-in 3.051 HRD-in -72.72, -56.56 85.97, -17.24 in-out-out SNCioo out-out ActLoopNT-out 7.969 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.37, 154.98 APE9-dihe-in -92.36, 117.27 APE8-dihe-out -54.75, -26.7 APE8-rot-na 329.63 APE67-dihe-in -71.32, -6.64 -59.57, -19.47 APE12-dist-na 19.16 APE11-dist-na 20.783 APE10-dist-na 19.319 APE9-dist-out 11.814 C488A,C584S None None XRAY 2.2 0.216 0.259 A 317 295 7 0 0 0 [[478, 756]] 1.0 3js2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3JS2B P11362 459 762 822.0 VM1:801 Type1 Inactive DFGin 5.166 12.915 BLAplus -117.79, 168.89 57.38, 26.57 -81.81, -21.58 58.31, 81.41 -101.15, 4.46 in-in in 7.415 Saltbr-in 2.898 HRD-in -70.61, -55.45 85.21, -19.22 in-out-out SNCioo out-out ActLoopNT-out 8.388 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.77, 164.88 APE9-dihe-in -101.88, 109.77 APE8-dihe-out -47.5, -33.8 APE8-rot-na 323.58 APE67-dihe-in -71.37, -10.85 -58.97, -16.94 APE12-dist-na 19.428 APE11-dist-na 20.934 APE10-dist-na 19.561 APE9-dist-out 11.776 C488A,C584S None None XRAY 2.2 0.216 0.259 B 317 291 13 0 0 0 [[478, 756]] 1.0 3js2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3GQLC P11362 463 766 822.0 GQL:1 Type1 Inactive DFGin 5.708 13.027 BLAplus -123.78, 172.03 54.97, 32.17 -87.82, -13.88 53.39, 70.63 -108.09, 38.81 in-in in 7.805 Saltbr-in 2.616 HRD-in -59.51, -40.97 72.56, -22.95 in-out-none SNCion out-none ActLoopNT-out 8.758 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -7.55 APE8-rot-na 32.95 APE67-dihe-in -61.65, -18.42 -80.52, -27.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 C 326 275 29 0 0 16 [[478, 756]] 1.0 3gql Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8JMZA P11362 460 765 822.0 UKI:60801 Type1 Inactive DFGin 5.159 13.289 BLAplus -113.58, 162.96 62.0, 28.58 -83.36, -13.84 56.58, 89.17 -102.65, 12.75 in-in in 7.859 Saltbr-in 2.835 HRD-in -72.3, -51.47 78.17, -4.24 in-out-out SNCioo out-out ActLoopNT-out 7.981 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.22, 148.56 APE9-dihe-in -107.32, 99.52 APE8-dihe-out -56.46, -18.86 APE8-rot-na 328.17 APE67-dihe-in -74.96, -9.03 -56.04, -27.86 APE12-dist-na 16.425 APE11-dist-na 18.997 APE10-dist-na 16.223 APE9-dist-out 11.021 C584S None None XRAY 1.988 0.166 0.205 A 310 306 0 0 0 0 [[478, 756]] 1.0 8jmz Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8JMZB P11362 458 763 822.0 UKI:60801 Type1 Inactive DFGin 5.259 13.007 BLAplus -114.88, 158.62 61.68, 33.22 -84.25, -18.02 53.38, 88.43 -92.93, -0.34 in-in in 7.767 Saltbr-in 2.924 HRD-in -72.45, -50.78 74.31, -4.23 in-out-out SNCioo out-out ActLoopNT-out 8.354 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -137.73, 168.34 APE9-dihe-in -103.17, 113.28 APE8-dihe-out -51.14, -25.22 APE8-rot-na 328.21 APE67-dihe-in -74.28, -2.47 -57.8, -24.89 APE12-dist-na 20.439 APE11-dist-na 21.401 APE10-dist-na 20.065 APE9-dist-out 11.501 C584S None None XRAY 1.988 0.166 0.205 B 310 290 16 0 0 3 [[478, 756]] 1.0 8jmz Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 9UHCA P11362 458 764 822.0 A1EPE:60801 Type1 Inactive DFGin 5.089 13.566 BLAplus -99.26, 163.63 67.92, 18.69 -73.13, -23.6 54.69, 89.65 -94.23, 7.24 in-in in 8.58 Saltbr-in 2.837 HRD-in -81.76, -52.28 81.48, -12.21 in-out-out SNCioo out-out ActLoopNT-out 7.689 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -93.01, 148.62 APE9-dihe-in -107.23, 98.65 APE8-dihe-out -61.69, -18.58 APE8-rot-na 332.39 APE67-dihe-in -73.38, -10.07 -53.51, -28.36 APE12-dist-na 17.33 APE11-dist-na 19.828 APE10-dist-na 16.888 APE9-dist-out 11.084 None None None XRAY 1.88 0.173 0.205 A 310 307 0 0 0 0 [[478, 756]] 1.0 9uhc Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 9UHCB P11362 458 763 822.0 A1EPE:60801 Type1 Inactive DFGin 5.28 12.91 BLAplus -104.01, 159.23 73.73, 21.61 -75.73, -25.49 53.38, 87.57 -92.18, 7.01 in-in in 7.958 Saltbr-in 3.264 HRD-in -83.66, -52.1 79.1, -13.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.36, 141.0 APE9-dihe-in -101.25, 92.23 APE8-dihe-out -59.77, -24.69 APE8-rot-na 330.6 APE67-dihe-in -77.73, -0.07 -57.66, -24.92 APE12-dist-na 17.39 APE11-dist-na 20.126 APE10-dist-na 17.109 APE9-dist-out 11.296 None None None XRAY 1.88 0.173 0.205 B 310 286 20 0 0 7 [[478, 756]] 1.0 9uhc Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 9UHIA P11362 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.436 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.251 Saltbr-in 2.888 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.511 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.672 APE10-dist-na 16.685 APE9-dist-out 11.083 None None None XRAY 1.76 0.163 0.197 A 310 307 0 0 0 0 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 9UHIB P11362 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.213 12.738 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.768 Saltbr-in 3.449 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.352 APE11-dist-na 20.682 APE10-dist-na 16.965 APE9-dist-out 11.364 None None None XRAY 1.76 0.163 0.197 B 310 286 20 0 0 7 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5A46A P11362 464 766 822.0 38O:1769 Type1 Inactive DFGin 5.213 13.149 BLAplus -118.77, 162.9 58.04, 28.78 -73.18, -26.4 58.45, 90.15 -96.03, 5.5 in-in in 7.513 Saltbr-in 3.005 HRD-in -57.82, -48.72 70.95, -11.29 in-out-out SNCioo out-out ActLoopNT-out 8.281 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.0, 143.36 APE9-dihe-in -88.58, 110.07 APE8-dihe-out -58.5, -16.77 APE8-rot-na 337.71 APE67-dihe-in -76.67, -10.73 -63.67, -15.99 APE12-dist-na 20.033 APE11-dist-na 21.324 APE10-dist-na 19.432 APE9-dist-out 12.089 None None None XRAY 2.63 0.182 0.246 A 386 290 13 0 0 3 [[478, 756]] 1.0 5a46 Homo sapiens TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5A46B P11362 458 766 822.0 38O:1767 Type1 Inactive DFGin 5.33 12.787 BLAplus -120.14, 161.93 66.72, 19.6 -75.13, -22.14 56.34, 83.44 -97.38, -0.25 in-in in 7.593 Saltbr-in 2.799 HRD-in -68.23, -43.1 73.28, -14.2 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -119.49, 150.14 APE9-dihe-in -90.22, 111.65 APE8-dihe-out -53.72, -24.65 APE8-rot-na 331.17 APE67-dihe-in -66.01, -7.4 -51.07, -30.75 APE12-dist-na 20.292 APE11-dist-na 21.271 APE10-dist-na 19.907 APE9-dist-out 11.879 None None None XRAY 2.63 0.182 0.246 B 386 298 11 0 0 0 [[478, 756]] 1.0 5a46 Homo sapiens TYR_FGFR1_HUMAN TYR 4.5e-104 353.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWKB P11362 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.737 13.232 BLAplus -119.15, 169.82 41.98, 44.21 -90.47, -9.61 54.08, 84.94 -94.37, 2.45 in-in in 8.416 Saltbr-in 3.448 HRD-in -74.45, -44.2 66.06, 8.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -133.04, 131.77 APE9-dihe-in -79.69, 122.84 APE8-dihe-out -69.38, -1.04 APE8-rot-na 339.66 APE67-dihe-in -75.83, -3.81 -84.39, -12.82 APE12-dist-na 999.0 APE11-dist-na 21.927 APE10-dist-na 19.835 APE9-dist-out 11.647 C488A,V561M,C584S None None XRAY 2.982 0.244 0.299 B 317 282 23 0 0 7 [[478, 756]] 1.0 4rwk Homo sapiens TYR_FGFR1_HUMAN TYR 8.4e-105 355.7 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3C4FA P11362 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.114 13.318 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.866 Saltbr-out 4.632 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.292 APE11-dist-na 21.121 APE10-dist-na 19.395 APE9-dist-out 11.757 C488A None None XRAY 2.07 0.213 0.264 A 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3C4FB P11362 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.186 13.096 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.831 Saltbr-in 3.248 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.934 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.37 APE11-dist-na 21.296 APE10-dist-na 19.671 APE9-dist-out 11.643 C488A None None XRAY 2.07 0.213 0.264 B 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3RHXA P11362 464 764 822.0 3RH:2 Type1.5_Back Inactive DFGin 5.232 13.424 BLAplus -115.51, 162.57 65.19, 24.13 -75.33, -9.38 51.51, 92.3 -110.55, 8.31 in-in in 7.911 Saltbr-in 2.711 HRD-in -70.15, -54.52 80.53, -17.3 in-out-out SNCioo out-out ActLoopNT-out 8.954 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.48, 163.59 APE9-dihe-in -103.14, 115.59 APE8-dihe-out -45.87, -31.01 APE8-rot-na 329.03 APE67-dihe-in -73.43, -8.98 -55.07, -22.7 APE12-dist-na 19.77 APE11-dist-na 20.938 APE10-dist-na 19.62 APE9-dist-out 11.697 C488A,C584S None None XRAY 2.01 0.205 0.262 A 306 289 12 0 0 0 [[478, 756]] 1.0 3rhx Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3RHXB P11362 461 761 822.0 3RH:1 Type1.5_Back Inactive DFGin 5.278 13.054 BLAplus -115.52, 168.31 59.14, 31.22 -88.71, -15.14 56.2, 82.95 -99.2, 10.03 in-in in 7.94 Saltbr-in 2.982 HRD-in -72.09, -51.52 83.53, -18.46 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.0, 155.03 APE9-dihe-in -98.71, 116.74 APE8-dihe-out -54.04, -23.88 APE8-rot-na 324.24 APE67-dihe-in -72.41, -9.32 -62.62, -17.17 APE12-dist-na 20.092 APE11-dist-na 21.395 APE10-dist-na 19.835 APE9-dist-out 11.621 C488A,C584S None None XRAY 2.01 0.205 0.262 B 306 275 26 0 0 6 [[478, 756]] 1.0 3rhx Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5A4CA P11362 464 765 822.0 XOJ:61774 Type1.5_Back Inactive DFGin 5.048 13.267 BLAplus -116.37, 165.87 49.91, 42.78 -84.97, -10.47 49.36, 85.77 -124.76, 35.25 in-in in 7.785 Saltbr-in 2.773 HRD-in -70.73, -50.48 78.51, -17.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.99, 158.13 APE9-dihe-in -97.5, 110.29 APE8-dihe-out -57.36, -20.43 APE8-rot-na 331.74 APE67-dihe-in -71.92, -10.57 -60.66, -19.9 APE12-dist-na 19.861 APE11-dist-na 20.995 APE10-dist-na 19.495 APE9-dist-out 11.806 C488A,C584S None None XRAY 2.09 0.197 0.235 A 307 294 8 0 0 6 [[478, 756]] 1.0 5a4c Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5A4CB P11362 461 765 822.0 XOJ:61772 Type1.5_Back Inactive DFGin 4.997 13.163 BLAplus -119.35, 160.02 53.79, 37.21 -79.91, -19.99 52.56, 81.88 -121.98, 47.25 in-in in 7.666 Saltbr-in 2.874 HRD-in -70.85, -51.35 80.75, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.16, 158.77 APE9-dihe-in -96.18, 111.18 APE8-dihe-out -54.21, -24.18 APE8-rot-na 331.2 APE67-dihe-in -62.46, -9.6 -52.41, -31.86 APE12-dist-na 20.081 APE11-dist-na 21.257 APE10-dist-na 19.71 APE9-dist-out 11.63 C488A,C584S None None XRAY 2.09 0.197 0.235 B 307 284 21 0 0 5 [[478, 756]] 1.0 5a4c Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4NK9B P11362 460 765 822.0 2K5:802 Type1.5_Back Inactive DFGin 5.825 13.219 BLAplus -122.38, 146.16 46.72, 66.95 -88.33, 79.62 27.47, 86.37 49.01, 999.0 in-in in 8.041 Saltbr-in 3.369 HRD-in -55.1, -51.05 76.42, -8.06 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -103.43, 153.75 APE9-dihe-in -96.17, 112.02 APE8-dihe-out -57.11, -19.43 APE8-rot-na 333.43 APE67-dihe-in -71.52, -2.84 -61.88, -22.97 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.773 C488A,C584S None None XRAY 2.57 0.209 0.262 B 309 282 24 0 0 8 [[478, 756]] 1.0 4nk9 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4V05A P11362 464 765 822.0 66T:1769 Type1.5_Back Inactive DFGin 5.473 13.42 BLAplus -110.72, 173.08 50.09, 39.57 -95.62, -19.67 60.09, 83.48 -87.99, 3.34 in-in in 8.048 Saltbr-in 2.75 HRD-in -64.72, -51.32 77.65, -23.6 in-out-out SNCioo out-out ActLoopNT-out 8.302 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.91, 158.86 APE9-dihe-in -104.86, 116.5 APE8-dihe-out -57.09, -23.19 APE8-rot-na 335.63 APE67-dihe-in -66.78, -18.31 -54.95, -24.99 APE12-dist-na 20.841 APE11-dist-na 21.808 APE10-dist-na 19.911 APE9-dist-out 11.602 None None None XRAY 2.57 0.196 0.256 A 309 287 15 0 0 4 [[478, 756]] 1.0 4v05 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4V05B P11362 459 764 822.0 66T:1767 Type1.5_Back Inactive DFGin 5.427 13.072 BLAplus -110.08, 173.06 48.31, 47.35 -106.86, -10.85 58.74, 86.16 -77.17, -18.0 in-in in 7.831 Saltbr-in 2.983 HRD-in -65.29, -47.82 74.06, -21.09 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.03, 160.1 APE9-dihe-in -100.97, 109.95 APE8-dihe-out -53.4, -23.19 APE8-rot-na 333.98 APE67-dihe-in -59.05, -11.55 -51.93, -35.21 APE12-dist-na 21.391 APE11-dist-na 22.089 APE10-dist-na 20.538 APE9-dist-out 11.465 None None None XRAY 2.57 0.196 0.256 B 309 286 20 0 0 4 [[478, 756]] 1.0 4v05 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5EW8A P11362 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.948 13.265 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.954 Saltbr-in 2.801 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.37 APE11-dist-na 20.743 APE10-dist-na 19.216 APE9-dist-out 11.882 None None None XRAY 1.63 0.186 0.206 A 309 291 11 0 0 0 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5EW8B P11362 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.002 13.124 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.88 Saltbr-in 2.807 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.38 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.902 APE11-dist-na 21.169 APE10-dist-na 19.654 APE9-dist-out 11.767 None None None XRAY 1.63 0.186 0.206 B 309 290 15 0 0 2 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 2FGIA P11362 464 762 822.0 PD1:1001 Type1.5_Back Inactive DFGin 5.121 13.427 BLAplus -112.68, 157.47 60.87, 36.89 -81.98, -32.37 53.09, 90.73 -98.47, 17.45 in-in in 7.747 Saltbr-in 2.901 HRD-in -72.72, -53.18 83.95, -27.1 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -126.75, 157.3 APE9-dihe-in -97.93, 112.9 APE8-dihe-out -58.5, -25.56 APE8-rot-na 326.54 APE67-dihe-in -72.23, -8.06 -59.01, -20.89 APE12-dist-na 19.922 APE11-dist-na 21.175 APE10-dist-na 19.322 APE9-dist-out 11.544 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 A 310 274 25 0 0 2 [[478, 756]] 1.0 2fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 2FGIB P11362 461 761 822.0 PD1:1000 Type1.5_Back Inactive DFGin 5.065 13.208 BLAplus -127.21, 161.09 62.19, 18.94 -71.59, -20.95 56.29, 90.56 -106.4, 12.05 in-in in 7.776 Saltbr-in 3.066 HRD-in -62.08, -49.35 70.47, -0.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -96.38, 171.1 APE9-dihe-in -103.55, 110.23 APE8-dihe-out -52.66, -22.87 APE8-rot-na 324.05 APE67-dihe-in -65.07, -15.18 -62.56, -23.42 APE12-dist-na 999.0 APE11-dist-na 20.195 APE10-dist-na 19.456 APE9-dist-out 11.655 L457V,C488A,C584S None None XRAY 2.5 0.204 0.264 B 310 272 29 0 0 9 [[478, 756]] 1.0 2fgi Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5B7VA P11362 464 763 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.579 13.122 BLAplus -124.02, 164.1 56.03, 35.18 -83.98, -18.11 54.48, 82.39 -93.9, 14.98 in-in in 7.675 Saltbr-in 3.025 HRD-in -66.75, -56.97 82.51, -19.31 in-out-out SNCioo out-out ActLoopNT-out 8.581 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.75, 145.14 APE9-dihe-in -88.05, 111.6 APE8-dihe-out -54.86, -24.86 APE8-rot-na 336.86 APE67-dihe-in -69.24, -8.96 -56.43, -23.01 APE12-dist-na 20.966 APE11-dist-na 21.63 APE10-dist-na 19.658 APE9-dist-out 12.019 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 A 310 282 18 0 0 3 [[478, 756]] 1.0 5b7v Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4WUNA P11362 465 765 822.0 66T:801 Type1.5_Back Inactive DFGin 5.359 13.287 BLAplus -114.51, 167.45 61.45, 33.19 -92.75, -3.72 56.8, 81.8 -94.63, -9.82 in-in in 7.925 Saltbr-in 2.943 HRD-in -77.57, -50.47 80.03, -11.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -31.68 APE8-rot-na 335.8 APE67-dihe-in -71.2, -7.75 -54.8, -30.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.65 0.226 0.247 A 311 282 19 0 0 18 [[478, 756]] 1.0 4wun Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4WUNB P11362 461 762 822.0 66T:801 Type1.5_Back Inactive DFGin 5.239 13.104 BLAplus -116.49, 163.26 61.87, 38.6 -99.56, -5.62 55.6, 83.98 -99.35, -2.08 in-in in 7.704 Saltbr-in 2.667 HRD-in -74.96, -47.89 70.35, -11.28 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 81.94 APE8-dihe-out -59.03, -20.07 APE8-rot-na 4.38 APE67-dihe-in -66.47, -11.9 -63.08, -22.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.202 None None None XRAY 1.65 0.226 0.247 B 311 268 34 0 0 17 [[478, 756]] 1.0 4wun Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5UR1A P11362 464 765 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.426 13.52 BLAplus -105.89, 156.77 50.9, 45.08 -90.42, 1.33 56.15, 80.94 -119.23, 19.57 in-in in 8.119 Saltbr-in 2.874 HRD-in -68.09, -57.16 83.23, -8.89 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -37.48 APE8-rot-na 0.79 APE67-dihe-in -68.25, -11.12 -55.14, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 A 311 278 24 0 0 18 [[478, 756]] 1.0 5ur1 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C18A P11362 465 765 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.436 13.468 BLAplus -111.24, 164.85 45.25, 45.5 -89.65, 12.35 52.19, 85.8 -112.52, 6.73 in-in in 8.115 Saltbr-in 2.978 HRD-in -70.43, -53.82 83.18, -8.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.11 APE8-rot-na 0.21 APE67-dihe-in -78.22, -8.43 -50.66, -26.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 A 311 276 25 0 0 18 [[478, 756]] 1.0 6c18 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C19A P11362 464 765 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.26 13.442 BLAplus -115.0, 156.31 53.23, 42.1 -90.35, 7.6 54.35, 87.97 -114.31, 9.09 in-in in 8.0 Saltbr-in 2.759 HRD-in -69.01, -56.23 81.64, -20.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 102.7 APE8-dihe-out -60.85, -19.74 APE8-rot-na 1.27 APE67-dihe-in -75.51, -3.9 -52.6, -25.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.319 None None None XRAY 2.12 0.207 0.239 A 311 276 26 0 0 17 [[478, 756]] 1.0 6c19 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C19B P11362 464 762 822.0 YY7:801 Type1.5_Back Inactive DFGin 5.425 13.275 BLAplus -112.97, 152.62 61.65, 40.35 -91.96, -0.71 58.29, 80.73 -101.35, 18.35 in-in in 7.888 Saltbr-in 2.677 HRD-in -74.47, -50.19 73.43, -16.16 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 88.31 APE8-dihe-out -50.83, -20.72 APE8-rot-na 330.47 APE67-dihe-in -67.26, -8.41 -54.06, -29.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.219 None None None XRAY 2.12 0.207 0.239 B 311 264 35 0 0 17 [[478, 756]] 1.0 6c19 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C1BA P11362 465 765 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.481 13.494 BLAplus -108.99, 153.45 58.08, 39.21 -83.57, -0.28 58.99, 81.41 -115.03, 23.43 in-in in 7.962 Saltbr-in 2.714 HRD-in -69.38, -56.84 85.63, -18.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -46.26 APE8-rot-na 2.4 APE67-dihe-in -77.29, -7.48 -43.43, -29.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.0 0.222 0.255 A 311 265 36 0 0 18 [[478, 756]] 1.0 6c1b Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C1BB P11362 463 762 822.0 YY4:801 Type1.5_Back Inactive DFGin 5.39 13.173 BLAplus -111.61, 149.0 60.67, 36.26 -77.03, -12.36 51.44, 84.41 -47.03, -51.79 in-in in 7.747 Saltbr-in 2.717 HRD-in -68.12, -50.23 87.75, -19.17 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 84.87 APE8-dihe-out -57.93, -21.43 APE8-rot-na 10.08 APE67-dihe-in -70.65, -8.86 -55.2, -24.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.308 C488A,C584S None None XRAY 2.0 0.222 0.255 B 311 256 44 0 0 17 [[478, 756]] 1.0 6c1b Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C1CA P11362 465 765 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.567 13.493 BLAplus -110.74, 156.89 46.01, 46.87 -92.39, 20.43 55.59, 84.88 -142.57, 39.38 in-in in 8.073 Saltbr-in 2.784 HRD-in -74.71, -57.54 87.89, -21.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.9 APE8-rot-na 351.03 APE67-dihe-in -75.96, -1.2 -53.74, -29.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.15 0.228 0.27 A 311 276 25 0 0 18 [[478, 756]] 1.0 6c1c Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C1CB P11362 463 763 822.0 YY6:801 Type1.5_Back Inactive DFGin 5.254 13.146 BLAplus -106.04, 150.67 54.89, 44.71 -87.15, 1.28 50.78, 77.72 -105.41, 5.99 in-in in 7.72 Saltbr-in 2.618 HRD-in -67.33, -48.84 84.75, -22.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.16 APE8-dihe-out -62.72, -16.38 APE8-rot-na 19.67 APE67-dihe-in -70.81, -7.72 -62.98, -22.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.411 C488A,C584S None None XRAY 2.15 0.228 0.27 B 311 267 34 0 0 16 [[478, 756]] 1.0 6c1c Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C1OA P11362 464 765 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.367 13.476 BLAplus -110.66, 158.04 49.97, 55.76 -104.93, -8.0 57.72, 84.41 -107.33, 33.26 in-in in 7.751 Saltbr-in 2.914 HRD-in -67.38, -50.88 76.07, -0.25 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -66.74 APE8-dihe-out -57.13, -28.25 APE8-rot-na 348.02 APE67-dihe-in -72.73, -9.95 -55.13, -30.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.08 C488A,C584S None None XRAY 2.29 0.239 0.276 A 311 280 22 0 0 17 [[478, 756]] 1.0 6c1o Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C1OB P11362 464 763 822.0 MK9:801 Type1.5_Back Inactive DFGin 5.252 13.353 BLAplus -111.97, 154.41 51.29, 49.54 -91.74, -22.47 56.2, 81.11 -92.83, 58.93 in-in in 7.916 Saltbr-in 3.174 HRD-in -68.78, -49.64 75.13, -1.26 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.32 APE8-rot-na 337.06 APE67-dihe-in -73.03, -7.64 -66.65, -25.72 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.29 0.239 0.276 B 311 262 38 0 0 18 [[478, 756]] 1.0 6c1o Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6MZQA P11362 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.099 13.258 BLAplus -119.38, 163.65 62.35, 33.69 -91.12, -0.33 55.27, 84.16 -120.86, 13.76 in-in in 7.949 Saltbr-in 2.678 HRD-in -73.6, -55.96 80.43, -5.0 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.61 APE8-rot-na 334.89 APE67-dihe-in -72.0, -8.25 -68.04, -26.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 A 311 277 24 0 0 18 [[478, 756]] 1.0 6mzq Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6MZQB P11362 462 761 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.229 13.06 BLAplus -109.43, 157.46 65.55, 34.29 -83.47, -21.73 59.11, 82.16 -85.45, 999.0 in-in in 7.783 Saltbr-in 2.85 HRD-in -69.06, -55.52 76.96, -3.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -39.35 APE8-rot-na 334.65 APE67-dihe-in -70.64, -10.51 -51.58, -30.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.196 0.23 B 311 260 40 0 0 19 [[478, 756]] 1.0 6mzq Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWJA P11362 458 764 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.264 13.557 BLAplus -111.1, 165.72 44.3, 59.14 -104.5, -7.94 52.98, 85.2 -108.93, 18.9 in-in in 8.064 Saltbr-in 3.125 HRD-in -76.03, -43.68 72.99, -8.16 in-out-out SNCioo out-out ActLoopNT-out 7.982 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.41, 138.95 APE9-dihe-in -108.01, 100.05 APE8-dihe-out -61.04, -14.23 APE8-rot-na 22.4 APE67-dihe-in -81.18, -2.01 -65.12, -23.42 APE12-dist-na 19.426 APE11-dist-na 20.457 APE10-dist-na 17.046 APE9-dist-out 11.32 C488A,C584S None None XRAY 2.489 0.204 0.25 A 317 306 1 0 0 1 [[478, 756]] 1.0 4rwj Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWJB P11362 459 763 822.0 66T:60801 Type1.5_Back Inactive DFGin 5.306 13.075 BLAplus -111.81, 166.65 44.09, 58.11 -104.8, -5.62 52.57, 84.61 -105.75, 19.27 in-in in 7.934 Saltbr-in 2.835 HRD-in -75.88, -44.44 70.84, -6.0 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.6, 139.99 APE9-dihe-in -106.55, 102.92 APE8-dihe-out -58.58, -14.6 APE8-rot-na 336.03 APE67-dihe-in -80.58, -2.45 -66.06, -21.44 APE12-dist-na 999.0 APE11-dist-na 21.707 APE10-dist-na 18.478 APE9-dist-out 11.547 C488A,C584S None None XRAY 2.489 0.204 0.25 B 317 282 23 0 0 10 [[478, 756]] 1.0 4rwj Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3GQLA P11362 463 774 822.0 GQL:1 Type1.5_Back Inactive DFGin 5.247 12.989 BLAplus -123.12, 162.21 54.12, 42.77 -89.74, -13.17 56.15, 71.6 -109.47, 50.5 in-in in 7.903 Saltbr-in 2.834 HRD-in -61.52, -47.63 72.57, -4.79 in-out-out SNCioo out-out ActLoopNT-out 8.925 ActLoopCT-out TYR APEdihe_oooai APEdist_aaao APE10-dihe-out -142.49, 22.73 APE9-dihe-out 65.92, 53.77 APE8-dihe-out -55.03, -39.73 APE8-rot-na 329.92 APE67-dihe-in -69.54, -5.25 -36.43, -34.58 APE12-dist-na 16.321 APE11-dist-na 15.25 APE10-dist-na 15.999 APE9-dist-out 11.315 C488A None None XRAY 2.8 0.252 0.289 A 326 287 25 0 0 12 [[478, 756]] 1.0 3gql Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3TT0A P11362 461 765 822.0 07J:1 Type1.5_Back Inactive DFGin 5.254 13.639 BLAplus -115.26, 155.31 53.22, 40.23 -81.24, -26.95 55.14, 87.79 -91.68, 21.07 in-in in 7.915 Saltbr-in 3.106 HRD-in -69.95, -51.8 74.05, -16.9 in-out-out SNCioo out-out ActLoopNT-out 7.614 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -110.94, 147.79 APE9-dihe-in -106.75, 107.95 APE8-dihe-out -68.73, -19.6 APE8-rot-na 342.28 APE67-dihe-in -78.56, -18.08 -54.41, -25.03 APE12-dist-na 17.102 APE11-dist-na 19.47 APE10-dist-na 16.731 APE9-dist-out 11.071 C584S None None XRAY 2.8 0.207 0.261 A 382 305 0 0 0 0 [[478, 756]] 1.0 3tt0 Homo sapiens TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3TT0B P11362 459 763 822.0 07J:1 Type1.5_Back Inactive DFGin 5.382 13.307 BLAplus -116.49, 155.58 53.39, 40.81 -79.81, -25.38 49.88, 91.88 -91.88, 20.46 in-in in 7.848 Saltbr-in 3.041 HRD-in -67.66, -50.02 73.72, -9.65 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 146.21 APE8-rot-na 352.76 APE67-dihe-out -93.95, -12.68 76.26, -23.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.8 0.207 0.261 B 382 272 33 0 0 17 [[478, 756]] 1.0 3tt0 Homo sapiens TYR_FGFR1_HUMAN TYR 3e-104 353.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8Y22A P11362 459 762 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 5.106 13.179 BLAplus -113.25, 160.17 59.08, 34.01 -79.21, -14.36 51.54, 87.27 -109.45, 13.99 in-in in 7.982 Saltbr-in 2.799 HRD-in -70.73, -44.6 68.63, 0.76 in-out-out SNCioo out-out ActLoopNT-out 9.029 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.2, 162.84 APE9-dihe-in -99.13, 115.53 APE8-dihe-out -57.19, -22.1 APE8-rot-na 334.84 APE67-dihe-in -76.32, -7.85 -61.99, -21.14 APE12-dist-na 19.645 APE11-dist-na 20.883 APE10-dist-na 19.478 APE9-dist-out 11.673 C584S None None XRAY 2.792 0.197 0.26 A 308 288 16 0 0 4 [[478, 756]] 1.0 8y22 Homo sapiens TYR_FGFR1_HUMAN TYR 2e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8Y22B P11362 463 765 822.0 A1LW9:801 Type1.5_Back Inactive DFGin 4.927 13.386 BLAplus -106.53, 165.87 49.37, 36.23 -76.81, -19.53 50.68, 85.1 -111.75, 14.63 in-in in 8.152 Saltbr-in 2.793 HRD-in -74.01, -46.1 72.79, 0.75 in-out-out SNCioo out-out ActLoopNT-out 8.596 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.29, 150.81 APE9-dihe-in -94.3, 115.55 APE8-dihe-out -59.96, -16.81 APE8-rot-na 335.23 APE67-dihe-in -86.59, -1.86 -68.36, -9.3 APE12-dist-na 19.374 APE11-dist-na 20.919 APE10-dist-na 19.145 APE9-dist-out 11.734 C584S None None XRAY 2.792 0.197 0.26 B 308 291 12 0 0 0 [[478, 756]] 1.0 8y22 Homo sapiens TYR_FGFR1_HUMAN TYR 2e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6NVLA P11362 463 765 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.128 13.311 BLAplus -119.52, 157.53 59.31, 34.82 -84.42, -16.16 59.33, 82.45 -101.42, 33.52 in-in in 7.59 Saltbr-in 2.865 HRD-in -75.42, -53.52 80.47, -2.41 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.68, 147.97 APE9-dihe-in -112.42, 91.75 APE8-dihe-out -47.21, -34.96 APE8-rot-na 327.61 APE67-dihe-in -66.06, -15.18 -49.22, -31.67 APE12-dist-na 17.287 APE11-dist-na 20.56 APE10-dist-na 17.182 APE9-dist-out 11.624 C584S None None XRAY 2.7 0.215 0.263 A 309 280 23 0 0 9 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6NVLB P11362 461 761 822.0 XL6:802 Type1.5_Back Inactive DFGin 5.29 13.112 BLAplus -110.71, 154.52 49.9, 58.02 -103.43, -14.13 54.73, 82.29 -99.41, 13.49 in-in in 7.623 Saltbr-in 3.025 HRD-in -62.36, -64.19 100.95, -30.38 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.63 APE8-rot-na 324.79 APE67-dihe-in -73.34, -7.41 -51.06, -32.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 B 309 263 38 0 0 18 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6NVLC P11362 465 761 822.0 XL6:801 Type1.5_Back Inactive DFGin 5.396 13.396 BLAplus -121.16, 162.24 42.87, 55.81 -103.48, -8.54 57.38, 81.17 -97.02, -26.48 in-in in 7.522 Saltbr-in 3.154 HRD-in -69.09, -49.97 76.47, -2.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -35.16 APE8-rot-na 328.72 APE67-dihe-in -78.06, -0.48 -64.76, -24.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C584S None None XRAY 2.7 0.215 0.263 C 309 265 32 0 0 9 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6NVLD P11362 471 762 822.0 XL6:804 Type1.5_Back Inactive DFGin 5.158 13.31 BLAplus -117.28, 161.88 52.71, 45.04 -93.07, -6.01 60.08, 84.31 -96.46, -42.94 in-none in 7.363 Saltbr-none 999.0 HRD-in -74.01, -57.04 84.17, -3.83 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.3, 154.56 APE9-dihe-in -112.92, 85.91 APE8-dihe-out -57.48, -12.84 APE8-rot-na 334.14 APE67-dihe-in -78.36, -8.15 -65.38, -24.93 APE12-dist-na 16.47 APE11-dist-na 19.401 APE10-dist-na 16.585 APE9-dist-out 11.335 C584S None None XRAY 2.7 0.215 0.263 D 309 269 23 0 0 9 [[478, 756]] 1.0 6nvl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7WCLA P11362 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.032 13.511 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.234 Saltbr-in 2.943 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.725 APE11-dist-na 19.067 APE10-dist-na 16.226 APE9-dist-out 11.223 C584S None None XRAY 2.495 0.195 0.23 A 310 306 0 0 0 0 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 7WCLB P11362 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.686 13.297 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.381 Saltbr-in 2.804 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.605 APE10-dist-na 19.498 APE9-dist-out 11.402 C584S None None XRAY 2.495 0.195 0.23 B 310 285 21 0 0 8 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8XLOA P11362 462 764 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.35 13.46 BLAplus -120.07, 167.95 56.19, 37.83 -98.04, 4.56 56.68, 90.6 -112.93, 25.35 in-in in 7.983 Saltbr-in 3.258 HRD-out -75.5, 142.74 -82.57, -37.38 in-out-out SNCioo out-out ActLoopNT-out 7.2 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -113.57, 158.46 APE9-dihe-in -97.47, 110.21 APE8-dihe-out -58.39, -18.54 APE8-rot-na 19.21 APE67-dihe-in -81.65, 0.42 -62.39, -18.82 APE12-dist-na 20.741 APE11-dist-na 21.946 APE10-dist-na 20.212 APE9-dist-out 11.778 C584S None None XRAY 2.36 0.21 0.255 A 310 293 10 0 0 0 [[478, 756]] 1.0 8xlo Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8XLOB P11362 458 763 822.0 A1LVQ:60801 Type1.5_Back Inactive DFGin 5.588 13.187 BLAplus -122.66, 168.69 59.17, 27.93 -79.17, -12.14 48.47, 88.63 -115.21, 3.75 in-in in 7.768 Saltbr-in 2.883 HRD-out -89.09, 129.19 -58.3, -36.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.09, 159.35 APE9-dihe-in -98.63, 108.84 APE8-dihe-out -54.34, -25.08 APE8-rot-na 331.75 APE67-dihe-in -70.85, 2.53 -59.01, -24.97 APE12-dist-na 19.448 APE11-dist-na 20.738 APE10-dist-na 19.3 APE9-dist-out 11.712 C584S None None XRAY 2.36 0.21 0.255 B 310 287 19 0 0 6 [[478, 756]] 1.0 8xlo Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8XZ7B P11362 461 765 822.0 A1LWW:60804 Type1.5_Back Inactive DFGin 5.277 13.486 BLAplus -115.92, 158.14 64.67, 33.78 -87.5, -12.64 58.12, 85.71 -91.55, 13.39 in-in in 8.268 Saltbr-in 2.974 HRD-in -72.69, -49.53 74.85, -11.34 in-out-out SNCioo out-out ActLoopNT-out 7.698 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -73.13, 157.52 APE9-dihe-in -120.81, 83.94 APE8-dihe-out -59.26, -16.83 APE8-rot-na 351.23 APE67-dihe-in -76.52, -7.27 -60.13, -24.1 APE12-dist-na 17.884 APE11-dist-na 19.581 APE10-dist-na 16.754 APE9-dist-out 11.09 C584S None None XRAY 1.75 0.188 0.225 B 310 303 2 0 0 0 [[478, 756]] 1.0 8xz7 Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6MZWA P11362 464 765 822.0 TZ0:801 Type1.5_Back Inactive DFGin 4.822 13.4 BLAplus -122.44, 164.99 57.07, 40.5 -90.84, 9.02 55.25, 82.2 -134.07, 2.85 in-in in 8.004 Saltbr-in 2.819 HRD-in -69.57, -56.52 83.74, -8.47 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -38.34 APE8-rot-na 329.11 APE67-dihe-in -82.69, 5.42 -51.99, -31.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 A 311 282 20 0 0 18 [[478, 756]] 1.0 6mzw Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5VNDA P11362 463 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.228 13.425 BLAplus -118.27, 161.79 56.96, 41.78 -93.83, -18.18 57.16, 83.64 -76.46, -2.88 in-in in 7.706 Saltbr-in 3.011 HRD-in -76.4, -51.16 70.96, 1.97 in-out-out SNCioo out-out ActLoopNT-out 8.385 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.26, 154.9 APE9-dihe-in -95.33, 115.63 APE8-dihe-out -58.5, -20.28 APE8-rot-na 328.5 APE67-dihe-in -71.98, -7.89 -57.67, -20.31 APE12-dist-na 20.247 APE11-dist-na 21.387 APE10-dist-na 19.746 APE9-dist-out 11.797 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 A 309 302 1 0 0 1 [[478, 756]] 1.0 5vnd Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5VNDB P11362 460 765 822.0 9ES:801 Type1.5_Back Inactive DFGin 5.286 13.219 BLAplus -116.66, 159.84 60.5, 40.74 -88.83, -28.65 56.85, 87.63 -76.11, -9.05 in-in in 7.643 Saltbr-in 3.135 HRD-in -75.25, -50.66 71.68, -1.94 in-out-out SNCioo out-out ActLoopNT-out 7.972 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -112.48, 159.45 APE9-dihe-in -96.83, 113.88 APE8-dihe-out -57.87, -23.88 APE8-rot-na 336.6 APE67-dihe-in -71.96, -8.45 -53.4, -22.22 APE12-dist-na 20.168 APE11-dist-na 21.399 APE10-dist-na 19.928 APE9-dist-out 11.65 C488A,Y563C,C584S None None XRAY 2.2 0.181 0.223 B 309 295 11 0 0 0 [[478, 756]] 1.0 5vnd Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6P68A P11362 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.568 13.297 BLAplus -124.18, 155.54 63.3, 48.78 -90.25, -51.15 37.68, 89.45 -72.78, 42.85 in-in in 8.463 Saltbr-in 3.068 HRD-in -82.33, -55.3 90.45, -28.65 in-out-out SNCioo out-out ActLoopNT-out 9.254 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.44, 166.09 APE9-dihe-in -115.93, 115.43 APE8-dihe-out -43.99, -17.59 APE8-rot-na 319.34 APE67-dihe-in -77.38, -22.95 -75.44, -11.63 APE12-dist-na 20.714 APE11-dist-na 21.756 APE10-dist-na 19.655 APE9-dist-out 11.592 C488A,Y563C None None XRAY 2.9 0.23 0.303 A 309 287 15 0 0 3 [[478, 756]] 1.0 6p68 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6P68B P11362 462 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.5 13.362 BLAplus -127.31, 162.51 46.96, 56.83 -101.23, -42.4 47.99, 77.97 -84.27, 46.6 in-in in 7.758 Saltbr-in 3.302 HRD-in -84.02, -53.61 84.39, -26.28 in-out-out SNCioo out-out ActLoopNT-out 8.846 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.18, 175.15 APE9-dihe-in -113.49, 131.98 APE8-dihe-out -57.6, -24.27 APE8-rot-na 330.67 APE67-dihe-in -68.05, -15.43 -68.07, -21.93 APE12-dist-na 20.753 APE11-dist-na 22.182 APE10-dist-na 20.562 APE9-dist-out 11.666 C488A,Y563C None None XRAY 2.9 0.23 0.303 B 309 286 16 0 0 3 [[478, 756]] 1.0 6p68 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6P68C P11362 463 763 822.0 O1Y:801 Type1.5_Back Inactive DFGin 5.821 13.216 BLAplus -111.29, 171.43 44.74, 37.04 -76.15, -58.04 39.05, 94.26 -70.98, 63.26 in-in in 7.372 Saltbr-in 2.885 HRD-in -80.62, -45.97 77.53, -19.73 in-out-out SNCioo out-out ActLoopNT-out 8.29 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.73, 161.83 APE9-dihe-in -111.63, 125.51 APE8-dihe-out -59.61, -24.78 APE8-rot-na 332.23 APE67-dihe-in -70.27, -21.8 -56.16, -23.37 APE12-dist-na 20.336 APE11-dist-na 21.442 APE10-dist-na 19.226 APE9-dist-out 11.324 C488A,Y563C None None XRAY 2.9 0.23 0.303 C 309 286 15 0 0 3 [[478, 756]] 1.0 6p68 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6P69A P11362 462 765 822.0 O21:804 Type1.5_Back Inactive DFGin 5.293 13.332 BLAplus -116.62, 153.51 68.44, 36.07 -94.14, -3.31 60.05, 82.99 -102.25, 17.21 in-in in 7.678 Saltbr-in 2.829 HRD-in -76.03, -50.91 79.25, -13.3 in-out-out SNCioo out-out ActLoopNT-out 6.92 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.91, 156.78 APE9-dihe-in -97.6, 112.94 APE8-dihe-out -56.34, -25.16 APE8-rot-na 341.33 APE67-dihe-in -73.31, -6.91 -51.65, -21.86 APE12-dist-na 20.852 APE11-dist-na 22.153 APE10-dist-na 20.372 APE9-dist-out 11.595 C488A,Y563C None None XRAY 2.2 0.189 0.245 A 309 288 16 0 0 0 [[478, 756]] 1.0 6p69 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6P69B P11362 461 762 822.0 O21:804 Type1.5_Back Inactive DFGin 5.238 12.992 BLAplus -110.73, 150.1 69.98, 35.36 -92.92, -8.35 56.07, 83.61 -81.3, 13.2 in-in in 7.674 Saltbr-in 2.723 HRD-in -71.89, -48.99 79.15, -25.42 in-out-out SNCioo out-out ActLoopNT-out 7.41 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.29, 160.07 APE9-dihe-in -97.38, 114.82 APE8-dihe-out -64.56, -21.47 APE8-rot-na 332.49 APE67-dihe-in -69.85, -7.92 -52.16, -22.61 APE12-dist-na 20.522 APE11-dist-na 21.686 APE10-dist-na 19.964 APE9-dist-out 11.454 C488A,Y563C None None XRAY 2.2 0.189 0.245 B 309 286 16 0 0 0 [[478, 756]] 1.0 6p69 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-103 351.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3KXXA P11362 461 765 822.0 No_ligand No_ligand Inactive DFGin 6.889 14.259 BLBminus -140.37, -169.46 63.26, 50.32 -78.18, 162.76 296.3, 66.09 151.64, -37.0 in-in in 7.017 Saltbr-in 2.83 HRD-out -100.04, 84.29 -55.69, -0.92 in-in-out SNCiio in-out ActLoopNT-in 2.902 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -104.55, 44.24 APE9-dihe-in -122.5, 136.32 APE8-dihe-in -50.57, 127.21 APE8-rot-na 327.84 APE67-dihe-in -76.36, 2.91 -67.27, -29.4 APE12-dist-na 14.337 APE11-dist-na 9.735 APE10-dist-na 7.861 APE9-dist-in 5.347 C488A,R577E,C584S None None XRAY 3.2 0.224 0.263 A 317 305 0 0 0 0 [[478, 756]] 1.0 3kxx Homo sapiens TYR_FGFR1_HUMAN TYR 2.4e-104 354.2 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8JQIB P11362 463 769 822.0 No_ligand No_ligand Inactive DFGin 5.58 13.702 BLBplus -110.39, 162.0 66.1, 18.22 -83.81, 164.72 63.85, 90.92 69.71, 13.55 in-in in 8.148 Saltbr-in 2.879 HRD-in -62.9, -42.83 68.84, -8.19 in-out-in SNCioi out-in ActLoopNT-out 7.708 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -95.84, 130.26 APE9-dihe-in -65.71, 153.24 APE8-dihe-in -72.54, 69.48 APE8-rot-na 18.0 APE67-dihe-in -81.24, 0.42 -61.21, -30.47 APE12-dist-na 18.004 APE11-dist-na 14.233 APE10-dist-na 16.408 APE9-dist-in 6.971 None None None EM 4.1 999.0 999.0 B 822 307 0 0 0 0 [[478, 756]] 1.0 8jqi Homo sapiens TYR_FGFR1_HUMAN TYR 3e-103 351.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8YKIA P11362 464 762 822.0 A1LY1:60801 Type1 Inactive DFGin 5.678 13.189 BLBplus -127.03, 161.47 55.43, 32.07 -78.75, 135.31 51.37, 81.9 67.66, 33.8 in-in in 7.996 Saltbr-in 3.228 HRD-in -69.63, -52.14 73.54, -1.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 150.66 APE8-dihe-out -68.91, -19.3 APE8-rot-na 29.84 APE67-dihe-in -67.55, -18.75 -54.73, -36.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.057 C488A None None XRAY 2.79 0.242 0.288 A 317 267 32 0 0 16 [[478, 756]] 1.0 8yki Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8YKIB P11362 461 761 822.0 A1LY1:60801 Type1 Inactive DFGin 5.816 13.002 BLBplus -127.51, 162.85 54.9, 31.45 -78.58, 134.89 51.65, 81.41 96.69, -107.12 in-in in 7.968 Saltbr-in 3.228 HRD-in -70.15, -51.98 73.59, -0.57 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.54 APE8-dihe-out -68.77, -19.51 APE8-rot-na 29.46 APE67-dihe-in -66.31, -19.61 -55.9, -35.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.131 C488A None None XRAY 2.79 0.242 0.288 B 317 264 37 0 0 17 [[478, 756]] 1.0 8yki Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 3GQLB P11362 463 765 822.0 GQL:1 Type1 Inactive DFGin 5.609 13.296 BLBplus -128.62, 167.94 48.28, 62.54 -111.2, 147.65 41.12, 83.15 54.74, 40.27 in-in in 8.088 Saltbr-in 2.95 HRD-in -58.11, -48.09 70.35, -6.25 in-out-none SNCion out-none ActLoopNT-out 8.853 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -21.24 APE8-rot-na 35.42 APE67-dihe-in -73.56, 1.23 -76.55, -20.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A None None XRAY 2.8 0.252 0.289 B 326 276 27 0 0 16 [[478, 756]] 1.0 3gql Homo sapiens TYR_FGFR1_HUMAN TYR 1.7e-104 354.6 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 8XZ7A P11362 458 765 822.0 A1LWW:60803 Type1 Inactive DFGin 5.582 13.023 BLBplus -119.64, 153.34 65.26, 30.33 -76.98, 170.32 51.66, 84.53 -174.68, 170.61 in-in in 8.21 Saltbr-in 2.896 HRD-out -86.18, 131.57 -68.41, -19.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -100.72, 163.01 APE9-dihe-in -98.35, 111.69 APE8-dihe-out -59.15, -22.66 APE8-rot-na 330.38 APE67-dihe-in -69.43, -4.98 -58.15, -24.4 APE12-dist-na 25.284 APE11-dist-na 26.442 APE10-dist-na 23.918 APE9-dist-out 11.351 C584S None None XRAY 1.75 0.188 0.225 A 310 297 11 0 0 4 [[478, 756]] 1.0 8xz7 Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5ZV2A P11362 463 762 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.568 14.144 BLBplus -131.08, 166.37 55.4, 22.07 -76.03, 127.13 51.59, 83.66 103.79, -116.47 in-in in 7.858 Saltbr-in 3.143 HRD-in -69.2, -53.37 81.07, -9.59 in-out-out SNCioo out-out ActLoopNT-out 9.185 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -156.95, 137.73 APE9-dihe-in -102.4, 101.23 APE8-dihe-out -65.35, -22.62 APE8-rot-na 30.52 APE67-dihe-in -64.41, -13.08 -61.44, -25.69 APE12-dist-na 18.712 APE11-dist-na 21.068 APE10-dist-na 17.839 APE9-dist-out 12.103 C488A None None XRAY 2.86 0.215 0.269 A 305 284 16 0 0 2 [[478, 756]] 1.0 5zv2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5ZV2B P11362 461 764 822.0 LEV:60801 Type1.5_Back Inactive DFGin 5.735 13.333 BLBplus -131.99, 168.42 59.16, 17.33 -69.91, 121.62 49.14, 91.18 109.73, -109.09 in-in in 7.949 Saltbr-in 2.867 HRD-in -69.21, -53.97 80.59, -9.94 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nioai APEdist_aaao APE10-dihe-none 999.0, 120.68 APE9-dihe-in -90.2, 111.18 APE8-dihe-out -62.93, -18.78 APE8-rot-na 29.94 APE67-dihe-in -66.68, -14.01 -56.35, -27.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.926 APE9-dist-out 11.61 C488A None None XRAY 2.86 0.215 0.269 B 305 281 23 0 0 10 [[478, 756]] 1.0 5zv2 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4NK9A P11362 464 765 822.0 2K5:807 Type1.5_Back Inactive DFGin 5.643 13.358 BLBplus -109.95, 156.55 39.62, 77.0 -103.05, 153.56 28.96, 73.43 57.1, 999.0 in-in in 8.098 Saltbr-in 3.363 HRD-in -55.46, -49.38 77.25, -13.07 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.12, 153.38 APE9-dihe-in -96.1, 111.38 APE8-dihe-out -57.95, -18.94 APE8-rot-na 334.9 APE67-dihe-in -71.02, -3.8 -60.59, -24.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.893 C488A,C584S None None XRAY 2.57 0.209 0.262 A 309 281 21 0 0 7 [[478, 756]] 1.0 4nk9 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5B7VB P11362 462 762 822.0 LWJ:801 Type1.5_Back Inactive DFGin 5.677 12.94 BLBplus -116.05, 161.84 53.01, 39.08 -76.06, 133.86 41.64, 92.29 65.64, 39.87 in-in in 7.617 Saltbr-in 3.029 HRD-in -64.13, -51.82 87.54, -28.51 in-out-out SNCioo out-out ActLoopNT-out 9.441 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -94.62, 144.39 APE9-dihe-in -82.91, 115.57 APE8-dihe-out -50.0, -27.69 APE8-rot-na 330.02 APE67-dihe-in -70.22, -11.34 -61.05, -21.38 APE12-dist-na 999.0 APE11-dist-na 19.998 APE10-dist-na 18.243 APE9-dist-out 11.702 L457V,C488A,C584S None None XRAY 2.15 0.224 0.256 B 310 277 24 0 0 6 [[478, 756]] 1.0 5b7v Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 5UR1B P11362 464 763 822.0 YY9:801 Type1.5_Back Inactive DFGin 5.291 13.248 BLBplus -105.41, 154.97 53.57, 37.31 -77.11, 166.16 58.26, 86.17 69.33, 25.51 in-in in 7.618 Saltbr-in 2.596 HRD-in -63.24, -51.37 83.2, -13.32 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -28.36 APE8-rot-na 342.42 APE67-dihe-in -76.21, -4.72 -69.35, -13.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.2 0.23 0.277 B 311 265 35 0 0 18 [[478, 756]] 1.0 5ur1 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4RWLB P11362 458 764 822.0 3ZC:801 Type1.5_Back Inactive DFGin 5.575 12.86 BLBplus -118.6, 158.89 63.82, 31.02 -77.01, 152.77 46.13, 88.04 75.46, -144.53 in-in in 7.864 Saltbr-in 2.714 HRD-in -76.64, -55.25 80.83, -9.47 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -108.43, 164.04 APE9-dihe-in -102.17, 112.77 APE8-dihe-out -51.59, -26.38 APE8-rot-na 327.68 APE67-dihe-in -76.33, -6.25 -60.23, -17.85 APE12-dist-na 20.462 APE11-dist-na 21.266 APE10-dist-na 19.748 APE9-dist-out 11.525 C488A,C584S None None XRAY 2.193 0.209 0.256 B 317 285 22 0 0 6 [[478, 756]] 1.0 4rwl Homo sapiens TYR_FGFR1_HUMAN TYR 1.6e-104 354.8 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4F65A P11362 464 765 822.0 0S9:808 Type1 Inactive DFGin 5.622 13.08 None -116.38, 166.24 56.16, 50.99 -96.21, 999.0 35.52, 82.62 999.0, 999.0 in-in in 7.976 Saltbr-in 2.925 HRD-in -64.44, -52.01 69.63, -13.8 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -105.26, 142.02 APE9-dihe-in -87.5, 110.31 APE8-dihe-out -50.81, -23.5 APE8-rot-na 336.61 APE67-dihe-in -69.73, -13.19 -59.55, -23.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.803 C488A,C584S None None XRAY 2.26 0.204 0.235 A 309 279 23 0 0 10 [[478, 756]] 1.0 4f65 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4NKAB P11362 458 765 822.0 2K7:803 Type1 Inactive DFGin 4.993 12.588 None -113.09, 172.85 51.3, 36.02 -81.11, 999.0 51.02, 79.07 999.0, 999.0 in-in in 7.721 Saltbr-in 2.819 HRD-in -68.57, -53.53 79.69, -21.71 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -99.94, 158.4 APE9-dihe-in -98.99, 111.75 APE8-dihe-out -53.76, -24.39 APE8-rot-na 331.5 APE67-dihe-in -68.26, -7.43 -55.44, -26.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.424 C488A,C584S None None XRAY 2.19 0.2 0.228 B 309 287 21 0 0 6 [[478, 756]] 1.0 4nka Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4F65B P11362 460 763 822.0 0S9:808 Type1.5_Back Inactive DFGin 6.172 11.744 None -112.37, 28.01 -137.92, 136.63 -123.39, 999.0 315.19, 98.45 999.0, 999.0 in-in in 7.928 Saltbr-in 2.908 HRD-in -72.51, -42.53 62.62, -12.9 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -120.78, 143.47 APE9-dihe-in -85.99, 110.74 APE8-dihe-out -51.4, -22.91 APE8-rot-na 337.29 APE67-dihe-in -68.78, -13.01 -59.73, -24.66 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.257 C488A,C584S None None XRAY 2.26 0.204 0.235 B 309 279 25 0 0 7 [[478, 756]] 1.0 4f65 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6C18B P11362 466 762 822.0 YY5:801 Type1.5_Back Inactive DFGin 5.466 13.156 None -121.52, 157.51 52.39, 50.92 -96.25, 999.0 51.2, 88.67 999.0, 999.0 in-in in 8.023 Saltbr-in 2.924 HRD-in -68.59, -52.77 77.43, -7.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -32.06 APE8-rot-na 331.63 APE67-dihe-in -71.45, -6.87 -51.83, -28.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 C488A,C584S None None XRAY 2.3 0.225 0.267 B 311 255 42 0 0 20 [[478, 756]] 1.0 6c18 Homo sapiens TYR_FGFR1_HUMAN TYR 1.5e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 6MZWB P11362 463 762 822.0 TZ0:801 Type1.5_Back Inactive DFGin 5.243 13.191 None -113.61, 162.19 59.99, 41.93 -84.77, 999.0 49.28, 82.5 999.0, 999.0 in-in in 7.816 Saltbr-in 2.684 HRD-in -70.89, -55.55 82.9, -7.56 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -23.86 APE8-rot-na 29.6 APE67-dihe-in -68.26, -6.41 -48.51, -43.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.244 0.297 B 311 258 42 0 0 20 [[478, 756]] 1.0 6mzw Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.3 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4V04B P11362 458 765 822.0 0LI:1771 Type2 Inactive DFGout 13.974 9.873 BBAminus -127.4, -173.98 -164.99, 120.92 -104.35, 44.71 306.97, 107.67 29.41, -12.23 in-in in 7.692 Saltbr-in 3.015 HRD-in -72.1, -51.88 81.11, -15.75 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.55, 155.16 APE9-dihe-in -98.03, 109.95 APE8-dihe-out -52.12, -21.56 APE8-rot-na 329.22 APE67-dihe-in -70.06, -7.36 -58.08, -24.0 APE12-dist-na 19.514 APE11-dist-na 20.97 APE10-dist-na 19.298 APE9-dist-out 11.591 C488A,C584S None None XRAY 2.12 0.188 0.228 B 309 289 19 0 0 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4V01A P11362 465 765 822.0 0LI:1776 Type2 Inactive DFGout 13.648 9.683 None -136.22, -176.63 -157.46, 111.62 -99.01, 999.0 301.26, 98.54 999.0, 999.0 in-in in 7.852 Saltbr-in 2.824 HRD-in -71.33, -57.3 83.26, -24.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.02, 147.14 APE9-dihe-in -94.17, 112.67 APE8-dihe-out -54.82, -21.48 APE8-rot-na 334.27 APE67-dihe-in -70.4, -11.17 -58.27, -24.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.727 C488A,C584S None None XRAY 2.33 0.191 0.238 A 309 273 28 0 0 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4V01B P11362 461 763 822.0 0LI:1770 Type2 Inactive DFGout 13.476 9.083 None -140.66, -178.05 -156.06, 123.42 -117.89, 999.0 302.59, 94.37 999.0, 999.0 in-in in 7.916 Saltbr-in 2.807 HRD-in -63.92, -54.57 77.31, -15.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -101.11, 164.12 APE9-dihe-in -107.61, 109.54 APE8-dihe-out -56.39, -11.31 APE8-rot-na 332.13 APE67-dihe-in -66.82, -7.77 -66.39, -26.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.814 C488A,C584S None None XRAY 2.33 0.191 0.238 B 309 275 28 0 0 8 [[478, 756]] 1.0 4v01 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
FGFR1_HUMAN 4V04A P11362 463 765 822.0 0LI:1772 Type2 Inactive DFGout 14.051 10.394 None -127.25, -179.24 -145.47, 116.11 -167.94, 35.9 26.55, 54.39 23.93, -5.2 in-in in 7.864 Saltbr-in 3.206 HRD-in -65.2, -58.04 83.28, -16.96 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.41, 155.12 APE9-dihe-in -98.09, 110.26 APE8-dihe-out -52.77, -21.99 APE8-rot-na 329.65 APE67-dihe-in -70.41, -8.08 -56.89, -24.83 APE12-dist-na 19.639 APE11-dist-na 21.02 APE10-dist-na 19.322 APE9-dist-out 11.7 C488A,C584S None None XRAY 2.12 0.188 0.228 A 309 293 10 0 0 6 [[478, 756]] 1.0 4v04 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1

TYR_FGFR1 (Fibroblast growth factor receptor 1)

Total number of chains: 0
Active chains: 0
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name