OTHER_EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Total number of chains: 12
Active chains: 2
Uniprot: E2AK2_HUMAN
Kinase Domain Residues: 267 - 538
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 41.7% AF-P19525-K1A
DFGin ABAminus 4 33.3% 8QELB
DFGin None 3 25.0% 3UIUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P19525-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 259 - 546 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
AF-P19525-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 259 - 546 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
2A19B 2.5 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase
2A19C 2.5 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase
2A1AB 2.8 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iioo No_ligand No_ligand 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase
8QELB 2.451 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaooo APEdist_iioo UH3 Type1 258 - 541 0 TPO446 None Interferon-induced, double-stranded RNA-activated protein kinase
6D3KA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 256 - 544 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
6D3KB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanio APEdist_nnnn ADP ATPlike 255 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
6D3KC 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 257 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
6D3LA 3.1 Inactive DFGin‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 258 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
3UIUA 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase
3UIUB 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase

OTHER_EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Total number of chains: 12
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 41.7% AF-P19525-K1A
DFGin ABAminus 4 33.3% 8QELB
DFGin None 3 25.0% 3UIUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
E2AK2_HUMAN AF-P19525-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 259 - 546 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN AF-P19525-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 259 - 546 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 2A19B 2.5 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 2A19C 2.5 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 2A1AB 2.8 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_iioo No_ligand No_ligand 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 8QELB 2.451 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaooo APEdist_iioo UH3 Type1 258 - 541 0 TPO446 None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 6D3KA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoo APEdist_nnnn ADP ATPlike 256 - 544 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 6D3KB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanio APEdist_nnnn ADP ATPlike 255 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 6D3KC 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ADP ATPlike 257 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 6D3LA 3.1 Inactive DFGin‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 258 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 3UIUA 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
E2AK2_HUMAN 3UIUB 2.903 Inactive DFGin‑None in-none in-out nonTYR APEdihe_aanno APEdist_nnnn No_ligand No_ligand 254 - 541 0 None None Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens

OTHER_EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism