OTHER_EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Total number of chains: 12
Active chains: 2
Uniprot: E2AK2_HUMAN
Kinase Domain Residues: 267 - 538
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 41.7% AF-P19525-K1A
DFGin ABAminus 4 33.3% 8QELB
DFGin None 3 25.0% 3UIUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EIF2AK2 AF-P19525-K1A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.3329 13.8338 BLAminus -132.8, -166.15 52.16, 75.52 -88.26, 20.77 290.79, 85.32 -63.1, -19.58 in-in in 8.4776 Saltbr-in 2.736 HRD-in -72.57, -46.6 69.03, -13.92 in-in-in SNCiii in-in ActLoopNT-in 2.8253 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.51, 128.47 APE9-dihe-na 130.95, 179.51 APE8-dihe-in -75.68, 113.45 APE8-rot-in 288.39 APE67-dihe-in -56.2, -32.95 -49.38, -38.3 APE12-dist-in 12.5055 APE11-dist-in 12.5844 APE10-dist-in 6.9466 APE9-dist-in 4.4055 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 27 27 0 [[175, 537]] 1.0 AF-P19525-K1 OTHER_EIF2AK2_HUMAN OTHER 2.3e-49 174.3 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 AF-P19525-K3A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.4368 14.688 BLAminus -132.88, -162.16 46.57, 66.9 -77.63, 15.78 288.57, 86.29 -62.83, -24.06 in-in in 8.2448 Saltbr-in 2.7265 HRD-in -72.61, -45.07 68.66, -19.19 in-in-in SNCiii in-in ActLoopNT-in 2.8759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.26, 124.49 APE9-dihe-na 137.76, -176.2 APE8-dihe-in -86.4, 108.58 APE8-rot-in 306.54 APE67-dihe-in -53.8, -42.4 -49.39, -37.75 APE12-dist-in 12.5809 APE11-dist-in 12.6447 APE10-dist-in 7.1855 APE9-dist-in 4.5889 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 27 27 0 [[175, 537]] 1.0 AF-P19525-K3 OTHER_EIF2AK2_HUMAN OTHER 2.3e-49 174.3 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.2846 14.3355 ABAminus -120.94, -28.83 -115.8, 107.84 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.2475 Saltbr-in 2.7306 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.0605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.5447 APE11-dist-in 10.8413 APE10-dist-out 10.3359 APE9-dist-out 9.8523 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284.0 262.0 9 27 27 0 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.9406 14.5579 ABAminus -118.27, -31.05 -99.56, 112.7 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.6955 Saltbr-in 3.4222 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284.0 202.0 69 27 5 22 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 2A1AB P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.2585 14.0395 ABAminus -132.54, 38.21 -152.54, 121.76 -125.72, 22.12 289.52, 72.9 -59.14, -10.25 in-in in 8.6278 Saltbr-in 2.6757 HRD-out -113.12, 112.61 -109.71, 52.22 in-in-out SNCiio in-out ActLoopNT-in 2.7985 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -135.52, 146.24 APE9-dihe-na 84.2, -133.27 APE8-dihe-in -88.04, 112.57 APE8-rot-out 53.95 APE67-dihe-out -49.6, 148.63 -66.06, -24.41 APE12-dist-in 12.7209 APE11-dist-in 10.2354 APE10-dist-out 9.499 APE9-dist-out 9.7473 H412N,C551A TPO446 TPO446 XRAY 2.8 0.213 0.268 B 284.0 267.0 4 27 27 0 [[175, 537]] 1.0 2a1a OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 8QELB P19525 258 541 551.0 UH3:64000 Type1 Inactive DFGin 6.6913 13.8168 ABAminus -110.21, -37.78 -88.63, 117.61 -118.7, 28.42 293.93, 84.05 -65.21, -26.2 in-in in 8.6392 Saltbr-in 3.0874 HRD-in -74.4, -47.11 71.83, -9.65 in-in-out SNCiio in-out ActLoopNT-in 2.8668 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -148.0, 101.41 APE9-dihe-na -176.3, -150.32 APE8-dihe-out -87.07, -2.65 APE8-rot-out 19.95 APE67-dihe-out -74.94, -36.92 29.55, 28.82 APE12-dist-in 12.8828 APE11-dist-in 10.5873 APE10-dist-out 11.1332 APE9-dist-out 9.1442 None TPO446 TPO446 XRAY 2.451 0.243 0.278 B 273.0 265.0 0 27 27 0 [[175, 537]] 1.0 8qel OTHER_EIF2AK2_HUMAN OTHER 5.3e-47 166.5 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.1925 14.1139 BLAminus -129.83, -165.99 54.1, 79.73 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.7206 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.9759 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323.0 258.0 31 27 17 10 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3934 14.2206 BLAminus -124.42, -164.03 49.77, 78.4 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.5703 Saltbr-in 2.9665 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.1489 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323.0 254.0 33 27 16 11 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3125 14.4662 BLAminus -121.59, -161.34 59.64, 70.11 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.5127 Saltbr-in 2.6756 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1936 None None None XRAY 2.6 0.212 0.266 C 323.0 258.0 27 27 24 3 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 6D3LA P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.4282 13.5478 None -156.44, 50.2 -150.13, 79.38 -93.22, 34.5 307.79, 100.69 -75.1, -22.66 in-out in 8.2504 Saltbr-out 4.2085 HRD-out -109.72, 76.87 -49.41, -33.81 out-in-none SNCoin in-none ActLoopNT-in 2.8933 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.263 0.347 A 323.0 248.0 36 27 10 17 [[175, 537]] 1.0 6d3l OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 3UIUA P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6173 12.2243 None 179.67, 47.65 -88.7, 86.35 -91.15, -3.67 303.64, 112.16 -78.11, 27.75 in-none in 8.5398 Saltbr-none 999.0 HRD-out -82.64, 83.35 -71.69, 48.72 none-in-out SNCnio in-out ActLoopNT-in 2.9471 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.49 APE8-rot-none 999.0 APE67-dihe-out -150.85, -147.51 -45.22, 110.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 A 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 3UIUB P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6133 12.222 None 179.62, 47.59 -88.43, 86.11 -90.92, -3.17 303.82, 112.2 -78.41, 27.48 in-none in 8.5339 Saltbr-none 999.0 HRD-out -82.77, 83.49 -72.08, 48.76 none-in-out SNCnio in-out ActLoopNT-in 2.9495 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.65 APE8-rot-none 999.0 APE67-dihe-out -150.91, -147.37 -45.27, 110.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 B 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase

OTHER_EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Total number of chains: 12
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 41.7% AF-P19525-K1A
DFGin ABAminus 4 33.3% 8QELB
DFGin None 3 25.0% 3UIUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
EIF2AK2 E2AK2_HUMAN AF-P19525-K1A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.3329 13.8338 BLAminus -132.8, -166.15 52.16, 75.52 -88.26, 20.77 290.79, 85.32 -63.1, -19.58 in-in in 8.4776 Saltbr-in 2.736 HRD-in -72.57, -46.6 69.03, -13.92 in-in-in SNCiii in-in ActLoopNT-in 2.8253 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.51, 128.47 APE9-dihe-na 130.95, 179.51 APE8-dihe-in -75.68, 113.45 APE8-rot-in 288.39 APE67-dihe-in -56.2, -32.95 -49.38, -38.3 APE12-dist-in 12.5055 APE11-dist-in 12.5844 APE10-dist-in 6.9466 APE9-dist-in 4.4055 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 27 27 0 [[175, 537]] 1.0 AF-P19525-K1 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 2.3e-49 174.3 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN AF-P19525-K3A P19525 259 546 551.0 No_ligand No_ligand Active DFGin 6.4368 14.688 BLAminus -132.88, -162.16 46.57, 66.9 -77.63, 15.78 288.57, 86.29 -62.83, -24.06 in-in in 8.2448 Saltbr-in 2.7265 HRD-in -72.61, -45.07 68.66, -19.19 in-in-in SNCiii in-in ActLoopNT-in 2.8759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.26, 124.49 APE9-dihe-na 137.76, -176.2 APE8-dihe-in -86.4, 108.58 APE8-rot-in 306.54 APE67-dihe-in -53.8, -42.4 -49.39, -37.75 APE12-dist-in 12.5809 APE11-dist-in 12.6447 APE10-dist-in 7.1855 APE9-dist-in 4.5889 None None None AF2 -1.0 1.0 1.0 A 288.0 288.0 0 27 27 0 [[175, 537]] 1.0 AF-P19525-K3 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 2.3e-49 174.3 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.2846 14.3355 ABAminus -120.94, -28.83 -115.8, 107.84 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.2475 Saltbr-in 2.7306 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.0605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.5447 APE11-dist-in 10.8413 APE10-dist-out 10.3359 APE9-dist-out 9.8523 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284.0 262.0 9 27 27 0 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.9406 14.5579 ABAminus -118.27, -31.05 -99.56, 112.7 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.6955 Saltbr-in 3.4222 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284.0 202.0 69 27 5 22 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 2A1AB P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.2585 14.0395 ABAminus -132.54, 38.21 -152.54, 121.76 -125.72, 22.12 289.52, 72.9 -59.14, -10.25 in-in in 8.6278 Saltbr-in 2.6757 HRD-out -113.12, 112.61 -109.71, 52.22 in-in-out SNCiio in-out ActLoopNT-in 2.7985 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -135.52, 146.24 APE9-dihe-na 84.2, -133.27 APE8-dihe-in -88.04, 112.57 APE8-rot-out 53.95 APE67-dihe-out -49.6, 148.63 -66.06, -24.41 APE12-dist-in 12.7209 APE11-dist-in 10.2354 APE10-dist-out 9.499 APE9-dist-out 9.7473 H412N,C551A TPO446 TPO446 XRAY 2.8 0.213 0.268 B 284.0 267.0 4 27 27 0 [[175, 537]] 1.0 2a1a Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 8QELB P19525 258 541 551.0 UH3:64000 Type1 Inactive DFGin 6.6913 13.8168 ABAminus -110.21, -37.78 -88.63, 117.61 -118.7, 28.42 293.93, 84.05 -65.21, -26.2 in-in in 8.6392 Saltbr-in 3.0874 HRD-in -74.4, -47.11 71.83, -9.65 in-in-out SNCiio in-out ActLoopNT-in 2.8668 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -148.0, 101.41 APE9-dihe-na -176.3, -150.32 APE8-dihe-out -87.07, -2.65 APE8-rot-out 19.95 APE67-dihe-out -74.94, -36.92 29.55, 28.82 APE12-dist-in 12.8828 APE11-dist-in 10.5873 APE10-dist-out 11.1332 APE9-dist-out 9.1442 None TPO446 TPO446 XRAY 2.451 0.243 0.278 B 273.0 265.0 0 27 27 0 [[175, 537]] 1.0 8qel Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 5.3e-47 166.5 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.1925 14.1139 BLAminus -129.83, -165.99 54.1, 79.73 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.7206 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.9759 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323.0 258.0 31 27 17 10 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3934 14.2206 BLAminus -124.42, -164.03 49.77, 78.4 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.5703 Saltbr-in 2.9665 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.1489 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323.0 254.0 33 27 16 11 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3125 14.4662 BLAminus -121.59, -161.34 59.64, 70.11 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.5127 Saltbr-in 2.6756 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1936 None None None XRAY 2.6 0.212 0.266 C 323.0 258.0 27 27 24 3 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 6D3LA P19525 258 541 551.0 No_ligand No_ligand Inactive DFGin 6.4282 13.5478 None -156.44, 50.2 -150.13, 79.38 -93.22, 34.5 307.79, 100.69 -75.1, -22.66 in-out in 8.2504 Saltbr-out 4.2085 HRD-out -109.72, 76.87 -49.41, -33.81 out-in-none SNCoin in-none ActLoopNT-in 2.8933 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.263 0.347 A 323.0 248.0 36 27 10 17 [[175, 537]] 1.0 6d3l Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 3UIUA P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6173 12.2243 None 179.67, 47.65 -88.7, 86.35 -91.15, -3.67 303.64, 112.16 -78.11, 27.75 in-none in 8.5398 Saltbr-none 999.0 HRD-out -82.64, 83.35 -71.69, 48.72 none-in-out SNCnio in-out ActLoopNT-in 2.9471 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.49 APE8-rot-none 999.0 APE67-dihe-out -150.85, -147.51 -45.22, 110.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 A 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
EIF2AK2 E2AK2_HUMAN 3UIUB P19525 254 541 551.0 No_ligand No_ligand Inactive DFGin 6.6133 12.222 None 179.62, 47.59 -88.43, 86.11 -90.92, -3.17 303.82, 112.2 -78.41, 27.48 in-none in 8.5339 Saltbr-none 999.0 HRD-out -82.77, 83.49 -72.08, 48.76 none-in-out SNCnio in-out ActLoopNT-in 2.9495 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.65 APE8-rot-none 999.0 APE67-dihe-out -150.91, -147.37 -45.27, 110.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.903 0.247 0.305 B 306.0 255.0 33 27 16 11 [[175, 537]] 1.0 3uiu Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.3e-48 170.6 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase

OTHER_EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name