Hover over column headers for tooltip help
| PDB | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AF-P19525-K1A | 259 | 546 | 551.0 | No_ligand | No_ligand | Active | DFGin | 6.333 | 13.834 | BLAminus | -132.8, -166.15 | 52.16, 75.52 | -88.26, 20.77 | 290.79, 85.32 | -63.1, -19.58 | in-in | in | 8.478 | Saltbr-in | 2.736 | HRD-in | -72.57, -46.6 | 69.03, -13.92 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.825 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.51, 128.47 | APE9-dihe-na | 130.95, 179.51 | APE8-dihe-in | -75.68, 113.45 | APE8-rot-in | 288.39 | APE67-dihe-in | -56.2, -32.95 | -49.38, -38.3 | APE12-dist-in | 12.505 | APE11-dist-in | 12.584 | APE10-dist-in | 6.947 | APE9-dist-in | 4.405 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 288 | 288 | 0 | 0 | 0 | 0 | [[175, 537]] | 1.0 | AF-P19525-K1 | OTHER_EIF2AK2_HUMAN | OTHER | 2.3e-49 | 174.3 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| AF-P19525-K3A | 259 | 546 | 551.0 | No_ligand | No_ligand | Active | DFGin | 6.437 | 14.688 | BLAminus | -132.88, -162.16 | 46.57, 66.9 | -77.63, 15.78 | 288.57, 86.29 | -62.83, -24.06 | in-in | in | 8.245 | Saltbr-in | 2.727 | HRD-in | -72.61, -45.07 | 68.66, -19.19 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.876 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -111.26, 124.49 | APE9-dihe-na | 137.76, -176.2 | APE8-dihe-in | -86.4, 108.58 | APE8-rot-in | 306.54 | APE67-dihe-in | -53.8, -42.4 | -49.39, -37.75 | APE12-dist-in | 12.581 | APE11-dist-in | 12.645 | APE10-dist-in | 7.186 | APE9-dist-in | 4.589 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 288 | 288 | 0 | 0 | 0 | 0 | [[175, 537]] | 1.0 | AF-P19525-K3 | OTHER_EIF2AK2_HUMAN | OTHER | 2.3e-49 | 174.3 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 2A19B | 258 | 541 | 551.0 | ANP:61640 | ATPlike | Inactive | DFGin | 6.285 | 14.335 | ABAminus | -120.94, -28.83 | -115.8, 107.84 | -103.04, 22.08 | 287.72, 80.44 | -61.97, -26.4 | in-in | in | 8.248 | Saltbr-in | 2.731 | HRD-in | -80.45, -51.29 | 75.68, -7.45 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.061 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | -131.92, 139.76 | APE9-dihe-na | 107.67, -147.72 | APE8-dihe-in | -73.7, 128.56 | APE8-rot-out | 9.97 | APE67-dihe-in | -50.1, -40.95 | -103.24, -6.7 | APE12-dist-in | 12.545 | APE11-dist-in | 10.841 | APE10-dist-out | 10.336 | APE9-dist-out | 9.852 | H412N,C551A | TPO446 | TPO446 | XRAY | 2.5 | 0.234 | 0.286 | B | 284 | 262 | 9 | 0 | 0 | 0 | [[175, 537]] | 1.0 | 2a19 | OTHER_EIF2AK2_HUMAN | OTHER | 6.2e-47 | 166.4 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 2A19C | 258 | 541 | 551.0 | ANP:62640 | ATPlike | Inactive | DFGin | 6.941 | 14.558 | ABAminus | -118.27, -31.05 | -99.56, 112.7 | -116.24, 24.93 | 286.16, 84.97 | -61.15, -35.53 | in-in | in | 7.696 | Saltbr-in | 3.422 | HRD-out | -95.69, 102.36 | -63.67, -30.07 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | H412N,C551A | TPO446 | TPO446 | XRAY | 2.5 | 0.234 | 0.286 | C | 284 | 202 | 69 | 0 | 0 | 22 | [[175, 537]] | 1.0 | 2a19 | OTHER_EIF2AK2_HUMAN | OTHER | 6.2e-47 | 166.4 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 2A1AB | 258 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.258 | 14.04 | ABAminus | -132.54, 38.21 | -152.54, 121.76 | -125.72, 22.12 | 289.52, 72.9 | -59.14, -10.25 | in-in | in | 8.628 | Saltbr-in | 2.676 | HRD-out | -113.12, 112.61 | -109.71, 52.22 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.799 | ActLoopCT-out | nonTYR | APEdihe_aaioo | APEdist_iioo | APE10-dihe-na | -135.52, 146.24 | APE9-dihe-na | 84.2, -133.27 | APE8-dihe-in | -88.04, 112.57 | APE8-rot-out | 53.95 | APE67-dihe-out | -49.6, 148.63 | -66.06, -24.41 | APE12-dist-in | 12.721 | APE11-dist-in | 10.235 | APE10-dist-out | 9.499 | APE9-dist-out | 9.747 | H412N,C551A | TPO446 | TPO446 | XRAY | 2.8 | 0.213 | 0.268 | B | 284 | 267 | 4 | 0 | 0 | 0 | [[175, 537]] | 1.0 | 2a1a | OTHER_EIF2AK2_HUMAN | OTHER | 6.2e-47 | 166.4 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 8QELB | 258 | 541 | 551.0 | UH3:64000 | Type1 | Inactive | DFGin | 6.691 | 13.817 | ABAminus | -110.21, -37.78 | -88.63, 117.61 | -118.7, 28.42 | 293.93, 84.05 | -65.21, -26.2 | in-in | in | 8.639 | Saltbr-in | 3.087 | HRD-in | -74.4, -47.11 | 71.83, -9.65 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.867 | ActLoopCT-out | nonTYR | APEdihe_aaooo | APEdist_iioo | APE10-dihe-na | -148.0, 101.41 | APE9-dihe-na | -176.3, -150.32 | APE8-dihe-out | -87.07, -2.65 | APE8-rot-out | 19.95 | APE67-dihe-out | -74.94, -36.92 | 29.55, 28.82 | APE12-dist-in | 12.883 | APE11-dist-in | 10.587 | APE10-dist-out | 11.133 | APE9-dist-out | 9.144 | None | TPO446 | TPO446 | XRAY | 2.451 | 0.243 | 0.278 | B | 273 | 265 | 0 | 0 | 0 | 0 | [[175, 537]] | 1.0 | 8qel | OTHER_EIF2AK2_HUMAN | OTHER | 5.3e-47 | 166.5 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 6D3KA | 256 | 544 | 551.0 | ADP:601 | ATPlike | Inactive | DFGin | 6.192 | 14.114 | BLAminus | -129.83, -165.99 | 54.1, 79.73 | -96.08, 34.77 | 294.46, 85.4 | -58.44, -36.42 | in-in | in | 8.721 | Saltbr-in | 3.027 | HRD-in | -84.66, -50.66 | 80.44, -19.76 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.976 | ActLoopCT-out | nonTYR | APEdihe_aanoo | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 139.0 | APE8-rot-out | 55.24 | APE67-dihe-out | -85.5, -25.12 | -112.78, 51.79 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.6 | 0.212 | 0.266 | A | 323 | 258 | 31 | 0 | 0 | 10 | [[175, 537]] | 1.0 | 6d3k | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 6D3KB | 255 | 541 | 551.0 | ADP:601 | ATPlike | Inactive | DFGin | 6.393 | 14.221 | BLAminus | -124.42, -164.03 | 49.77, 78.4 | -95.78, 27.52 | 286.59, 80.74 | -46.98, -40.31 | in-in | in | 8.57 | Saltbr-in | 2.966 | HRD-in | -83.22, -38.98 | 75.5, -28.78 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.149 | ActLoopCT-out | nonTYR | APEdihe_aanio | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, -18.31 | APE8-rot-in | 303.08 | APE67-dihe-out | -107.33, 146.38 | 64.92, 69.11 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.6 | 0.212 | 0.266 | B | 323 | 254 | 33 | 0 | 0 | 11 | [[175, 537]] | 1.0 | 6d3k | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 6D3KC | 257 | 541 | 551.0 | ADP:601 | ATPlike | Inactive | DFGin | 6.312 | 14.466 | BLAminus | -121.59, -161.34 | 59.64, 70.11 | -92.29, 27.04 | 287.49, 78.94 | -65.31, -34.89 | in-in | in | 8.513 | Saltbr-in | 2.676 | HRD-in | -58.89, -48.8 | 72.65, -1.02 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.885 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 168.95 | APE8-dihe-in | -45.87, 135.3 | APE8-rot-out | 180.18 | APE67-dihe-in | -61.65, -21.89 | -90.59, -3.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 10.194 | None | None | None | XRAY | 2.6 | 0.212 | 0.266 | C | 323 | 258 | 27 | 0 | 0 | 3 | [[175, 537]] | 1.0 | 6d3k | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 6D3LA | 258 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.428 | 13.548 | None | -156.44, 50.2 | -150.13, 79.38 | -93.22, 34.5 | 307.79, 100.69 | -75.1, -22.66 | in-out | in | 8.25 | Saltbr-out | 4.208 | HRD-out | -109.72, 76.87 | -49.41, -33.81 | out-in-none | SNCoin | in-none | ActLoopNT-in | 2.893 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 3.1 | 0.263 | 0.347 | A | 323 | 248 | 36 | 0 | 0 | 17 | [[175, 537]] | 1.0 | 6d3l | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 3UIUA | 254 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.617 | 12.224 | None | 179.67, 47.65 | -88.7, 86.35 | -91.15, -3.67 | 303.64, 112.16 | -78.11, 27.75 | in-none | in | 8.54 | Saltbr-none | 999.0 | HRD-out | -82.64, 83.35 | -71.69, 48.72 | none-in-out | SNCnio | in-out | ActLoopNT-in | 2.947 | ActLoopCT-out | nonTYR | APEdihe_aanno | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 76.49 | APE8-rot-none | 999.0 | APE67-dihe-out | -150.85, -147.51 | -45.22, 110.19 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.903 | 0.247 | 0.305 | A | 306 | 255 | 33 | 0 | 0 | 11 | [[175, 537]] | 1.0 | 3uiu | OTHER_EIF2AK2_HUMAN | OTHER | 3.3e-48 | 170.6 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| 3UIUB | 254 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.613 | 12.222 | None | 179.62, 47.59 | -88.43, 86.11 | -90.92, -3.17 | 303.82, 112.2 | -78.41, 27.48 | in-none | in | 8.534 | Saltbr-none | 999.0 | HRD-out | -82.77, 83.49 | -72.08, 48.76 | none-in-out | SNCnio | in-out | ActLoopNT-in | 2.95 | ActLoopCT-out | nonTYR | APEdihe_aanno | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 76.65 | APE8-rot-none | 999.0 | APE67-dihe-out | -150.91, -147.37 | -45.27, 110.1 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.903 | 0.247 | 0.305 | B | 306 | 255 | 33 | 0 | 0 | 11 | [[175, 537]] | 1.0 | 3uiu | OTHER_EIF2AK2_HUMAN | OTHER | 3.3e-48 | 170.6 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
Hover over column headers for tooltip help
| SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E2AK2_HUMAN | AF-P19525-K1A | P19525 | 259 | 546 | 551.0 | No_ligand | No_ligand | Active | DFGin | 6.333 | 13.834 | BLAminus | -132.8, -166.15 | 52.16, 75.52 | -88.26, 20.77 | 290.79, 85.32 | -63.1, -19.58 | in-in | in | 8.478 | Saltbr-in | 2.736 | HRD-in | -72.57, -46.6 | 69.03, -13.92 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.825 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -124.51, 128.47 | APE9-dihe-na | 130.95, 179.51 | APE8-dihe-in | -75.68, 113.45 | APE8-rot-in | 288.39 | APE67-dihe-in | -56.2, -32.95 | -49.38, -38.3 | APE12-dist-in | 12.505 | APE11-dist-in | 12.584 | APE10-dist-in | 6.947 | APE9-dist-in | 4.405 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 288 | 288 | 0 | 0 | 0 | 0 | [[175, 537]] | 1.0 | AF-P19525-K1 | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 2.3e-49 | 174.3 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | AF-P19525-K3A | P19525 | 259 | 546 | 551.0 | No_ligand | No_ligand | Active | DFGin | 6.437 | 14.688 | BLAminus | -132.88, -162.16 | 46.57, 66.9 | -77.63, 15.78 | 288.57, 86.29 | -62.83, -24.06 | in-in | in | 8.245 | Saltbr-in | 2.727 | HRD-in | -72.61, -45.07 | 68.66, -19.19 | in-in-in | SNCiii | in-in | ActLoopNT-in | 2.876 | ActLoopCT-in | nonTYR | APEdihe_aaiii | APEdist_iiii | APE10-dihe-na | -111.26, 124.49 | APE9-dihe-na | 137.76, -176.2 | APE8-dihe-in | -86.4, 108.58 | APE8-rot-in | 306.54 | APE67-dihe-in | -53.8, -42.4 | -49.39, -37.75 | APE12-dist-in | 12.581 | APE11-dist-in | 12.645 | APE10-dist-in | 7.186 | APE9-dist-in | 4.589 | None | None | None | AF2 | -1.0 | 1.0 | 1.0 | A | 288 | 288 | 0 | 0 | 0 | 0 | [[175, 537]] | 1.0 | AF-P19525-K3 | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 2.3e-49 | 174.3 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 2A19B | P19525 | 258 | 541 | 551.0 | ANP:61640 | ATPlike | Inactive | DFGin | 6.285 | 14.335 | ABAminus | -120.94, -28.83 | -115.8, 107.84 | -103.04, 22.08 | 287.72, 80.44 | -61.97, -26.4 | in-in | in | 8.248 | Saltbr-in | 2.731 | HRD-in | -80.45, -51.29 | 75.68, -7.45 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.061 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | -131.92, 139.76 | APE9-dihe-na | 107.67, -147.72 | APE8-dihe-in | -73.7, 128.56 | APE8-rot-out | 9.97 | APE67-dihe-in | -50.1, -40.95 | -103.24, -6.7 | APE12-dist-in | 12.545 | APE11-dist-in | 10.841 | APE10-dist-out | 10.336 | APE9-dist-out | 9.852 | H412N,C551A | TPO446 | TPO446 | XRAY | 2.5 | 0.234 | 0.286 | B | 284 | 262 | 9 | 0 | 0 | 0 | [[175, 537]] | 1.0 | 2a19 | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 6.2e-47 | 166.4 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 2A19C | P19525 | 258 | 541 | 551.0 | ANP:62640 | ATPlike | Inactive | DFGin | 6.941 | 14.558 | ABAminus | -118.27, -31.05 | -99.56, 112.7 | -116.24, 24.93 | 286.16, 84.97 | -61.15, -35.53 | in-in | in | 7.696 | Saltbr-in | 3.422 | HRD-out | -95.69, 102.36 | -63.67, -30.07 | in-none-none | SNCinn | none-none | ActLoopNT-none | 999.0 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | H412N,C551A | TPO446 | TPO446 | XRAY | 2.5 | 0.234 | 0.286 | C | 284 | 202 | 69 | 0 | 0 | 22 | [[175, 537]] | 1.0 | 2a19 | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 6.2e-47 | 166.4 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 2A1AB | P19525 | 258 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.258 | 14.04 | ABAminus | -132.54, 38.21 | -152.54, 121.76 | -125.72, 22.12 | 289.52, 72.9 | -59.14, -10.25 | in-in | in | 8.628 | Saltbr-in | 2.676 | HRD-out | -113.12, 112.61 | -109.71, 52.22 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.799 | ActLoopCT-out | nonTYR | APEdihe_aaioo | APEdist_iioo | APE10-dihe-na | -135.52, 146.24 | APE9-dihe-na | 84.2, -133.27 | APE8-dihe-in | -88.04, 112.57 | APE8-rot-out | 53.95 | APE67-dihe-out | -49.6, 148.63 | -66.06, -24.41 | APE12-dist-in | 12.721 | APE11-dist-in | 10.235 | APE10-dist-out | 9.499 | APE9-dist-out | 9.747 | H412N,C551A | TPO446 | TPO446 | XRAY | 2.8 | 0.213 | 0.268 | B | 284 | 267 | 4 | 0 | 0 | 0 | [[175, 537]] | 1.0 | 2a1a | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 6.2e-47 | 166.4 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 8QELB | P19525 | 258 | 541 | 551.0 | UH3:64000 | Type1 | Inactive | DFGin | 6.691 | 13.817 | ABAminus | -110.21, -37.78 | -88.63, 117.61 | -118.7, 28.42 | 293.93, 84.05 | -65.21, -26.2 | in-in | in | 8.639 | Saltbr-in | 3.087 | HRD-in | -74.4, -47.11 | 71.83, -9.65 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.867 | ActLoopCT-out | nonTYR | APEdihe_aaooo | APEdist_iioo | APE10-dihe-na | -148.0, 101.41 | APE9-dihe-na | -176.3, -150.32 | APE8-dihe-out | -87.07, -2.65 | APE8-rot-out | 19.95 | APE67-dihe-out | -74.94, -36.92 | 29.55, 28.82 | APE12-dist-in | 12.883 | APE11-dist-in | 10.587 | APE10-dist-out | 11.133 | APE9-dist-out | 9.144 | None | TPO446 | TPO446 | XRAY | 2.451 | 0.243 | 0.278 | B | 273 | 265 | 0 | 0 | 0 | 0 | [[175, 537]] | 1.0 | 8qel | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 5.3e-47 | 166.5 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 6D3KA | P19525 | 256 | 544 | 551.0 | ADP:601 | ATPlike | Inactive | DFGin | 6.192 | 14.114 | BLAminus | -129.83, -165.99 | 54.1, 79.73 | -96.08, 34.77 | 294.46, 85.4 | -58.44, -36.42 | in-in | in | 8.721 | Saltbr-in | 3.027 | HRD-in | -84.66, -50.66 | 80.44, -19.76 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.976 | ActLoopCT-out | nonTYR | APEdihe_aanoo | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 139.0 | APE8-rot-out | 55.24 | APE67-dihe-out | -85.5, -25.12 | -112.78, 51.79 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.6 | 0.212 | 0.266 | A | 323 | 258 | 31 | 0 | 0 | 10 | [[175, 537]] | 1.0 | 6d3k | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 6D3KB | P19525 | 255 | 541 | 551.0 | ADP:601 | ATPlike | Inactive | DFGin | 6.393 | 14.221 | BLAminus | -124.42, -164.03 | 49.77, 78.4 | -95.78, 27.52 | 286.59, 80.74 | -46.98, -40.31 | in-in | in | 8.57 | Saltbr-in | 2.966 | HRD-in | -83.22, -38.98 | 75.5, -28.78 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.149 | ActLoopCT-out | nonTYR | APEdihe_aanio | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, -18.31 | APE8-rot-in | 303.08 | APE67-dihe-out | -107.33, 146.38 | 64.92, 69.11 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.6 | 0.212 | 0.266 | B | 323 | 254 | 33 | 0 | 0 | 11 | [[175, 537]] | 1.0 | 6d3k | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 6D3KC | P19525 | 257 | 541 | 551.0 | ADP:601 | ATPlike | Inactive | DFGin | 6.312 | 14.466 | BLAminus | -121.59, -161.34 | 59.64, 70.11 | -92.29, 27.04 | 287.49, 78.94 | -65.31, -34.89 | in-in | in | 8.513 | Saltbr-in | 2.676 | HRD-in | -58.89, -48.8 | 72.65, -1.02 | in-in-out | SNCiio | in-out | ActLoopNT-in | 2.885 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 168.95 | APE8-dihe-in | -45.87, 135.3 | APE8-rot-out | 180.18 | APE67-dihe-in | -61.65, -21.89 | -90.59, -3.16 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 10.194 | None | None | None | XRAY | 2.6 | 0.212 | 0.266 | C | 323 | 258 | 27 | 0 | 0 | 3 | [[175, 537]] | 1.0 | 6d3k | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 6D3LA | P19525 | 258 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.428 | 13.548 | None | -156.44, 50.2 | -150.13, 79.38 | -93.22, 34.5 | 307.79, 100.69 | -75.1, -22.66 | in-out | in | 8.25 | Saltbr-out | 4.208 | HRD-out | -109.72, 76.87 | -49.41, -33.81 | out-in-none | SNCoin | in-none | ActLoopNT-in | 2.893 | ActLoopCT-none | nonTYR | APEdihe_aannn | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 999.0 | APE8-rot-none | 999.0 | APE67-dihe-none | 999.0, 999.0 | 999.0, 999.0 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 3.1 | 0.263 | 0.347 | A | 323 | 248 | 36 | 0 | 0 | 17 | [[175, 537]] | 1.0 | 6d3l | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 3.5e-49 | 173.8 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 3UIUA | P19525 | 254 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.617 | 12.224 | None | 179.67, 47.65 | -88.7, 86.35 | -91.15, -3.67 | 303.64, 112.16 | -78.11, 27.75 | in-none | in | 8.54 | Saltbr-none | 999.0 | HRD-out | -82.64, 83.35 | -71.69, 48.72 | none-in-out | SNCnio | in-out | ActLoopNT-in | 2.947 | ActLoopCT-out | nonTYR | APEdihe_aanno | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 76.49 | APE8-rot-none | 999.0 | APE67-dihe-out | -150.85, -147.51 | -45.22, 110.19 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.903 | 0.247 | 0.305 | A | 306 | 255 | 33 | 0 | 0 | 11 | [[175, 537]] | 1.0 | 3uiu | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 3.3e-48 | 170.6 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| E2AK2_HUMAN | 3UIUB | P19525 | 254 | 541 | 551.0 | No_ligand | No_ligand | Inactive | DFGin | 6.613 | 12.222 | None | 179.62, 47.59 | -88.43, 86.11 | -90.92, -3.17 | 303.82, 112.2 | -78.41, 27.48 | in-none | in | 8.534 | Saltbr-none | 999.0 | HRD-out | -82.77, 83.49 | -72.08, 48.76 | none-in-out | SNCnio | in-out | ActLoopNT-in | 2.95 | ActLoopCT-out | nonTYR | APEdihe_aanno | APEdist_nnnn | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, 999.0 | APE8-dihe-none | 999.0, 76.65 | APE8-rot-none | 999.0 | APE67-dihe-out | -150.91, -147.37 | -45.27, 110.1 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-none | 999.0 | None | None | None | XRAY | 2.903 | 0.247 | 0.305 | B | 306 | 255 | 33 | 0 | 0 | 11 | [[175, 537]] | 1.0 | 3uiu | Homo sapiens | OTHER_EIF2AK2_HUMAN | OTHER | 3.3e-48 | 170.6 | 1 | 256 | 256 | 431 | 432 | 433 | 435 | 437 | 296 | 308 | 312 | 411 | 413 | 412 | 414 | 470 | 458 | 453 | 452 | 451 | 450 | 449 | 448 | 447 | 367 | Interferon-induced, double-stranded RNA-activated protein kinase |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
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