TYR_CSF1R (Macrophage colony-stimulating factor 1 receptor)

Total number of chains: 24
Active chains: 3
Uniprot: CSF1R_HUMAN
Kinase Domain Residues: 582 - 912
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 20 83.3% 3BEAA
DFGin BLAminus 3 12.5% AF-P07333-K1A
DFGout None 1 4.2% 2OGVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P07333-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 574 - 920 0 None None Macrophage colony-stimulating factor 1 receptor
AF-P07333-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 574 - 920 0 None None Macrophage colony-stimulating factor 1 receptor
3LCDA 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai BDY Type1 558 - 913 0 None None Macrophage colony-stimulating factor 1 receptor
8CGCA 1.925 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai LMR, UIK Allosteric, Type1 547 - 919 0 None None Macrophage colony-stimulating factor 1 receptor
3BEAA 2.02 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai IXH Type1 547 - 921 0 None A933L Macrophage colony-stimulating factor 1 receptor
2I1MA 1.8 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai 5CN Type1 547 - 921 0 None None Macrophage colony-stimulating factor 1 receptor
8JOTA 1.69 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai UKI Type1 543 - 914 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor
8W1LA 2.26 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A1AE3 Type1 563 - 914 0 None None Macrophage colony-stimulating factor 1 receptor
2I0VA 2.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 6C3 Type1 544 - 916 0 None None Macrophage colony-stimulating factor 1 receptor
2I0YA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 5CN Type1 548 - 916 0 None None Macrophage colony-stimulating factor 1 receptor
3KRJA 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai KRJ Type1 544 - 914 0 None S686S Macrophage colony-stimulating factor 1 receptor
3KRLA 2.4 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai KRL Type1 545 - 912 0 None S686S Macrophage colony-stimulating factor 1 receptor
7TNHA 2.7 Inactive DFGout‑BBAminus in-none out-in TYR APEdihe_iiiai APEdist_aaai I9W Type1 445 - 912 0 None None Macrophage colony-stimulating factor 1 receptor
6T2WA 1.7 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai M9T Type1 547 - 916 0 None None Macrophage colony-stimulating factor 1 receptor
3DPKA 1.95 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_niiai APEdist_aaai 8C5 Type1.5_Back 548 - 912 0 None None Macrophage colony-stimulating factor 1 receptor
4HW7A 2.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 64M Type2 566 - 914 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor
4R7HA 2.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai P31 Type2 544 - 915 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor
4R7IA 2.75 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 567 - 914 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor
6N33A 2.25 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 622 Type2 566 - 915 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor
7MFCA 2.8 Inactive DFGout‑BBAminus in-none out-in TYR APEdihe_iiiai APEdist_aaai Z6V Type2 567 - 913 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor
6WXJA 2.62 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_nniai APEdist_aaai UF4 Type2 559 - 917 0 None None Macrophage colony-stimulating factor 1 receptor
3LCOA 3.4 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_niiai APEdist_aaai LC0 Type2 551 - 915 0 None None Macrophage colony-stimulating factor 1 receptor
6IG8A 1.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A7O Type2 550 - 916 0 None S688A Macrophage colony-stimulating factor 1 receptor
2OGVA 2.7 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 543 - 918 0 None None Macrophage colony-stimulating factor 1 receptor

TYR_CSF1R (Macrophage colony-stimulating factor 1 receptor)

Total number of chains: 24
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 20 83.3% 3BEAA
DFGin BLAminus 3 12.5% AF-P07333-K1A
DFGout None 1 4.2% 2OGVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CSF1R_HUMAN AF-P07333-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 574 - 920 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN AF-P07333-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 574 - 920 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 3LCDA 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai BDY Type1 558 - 913 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 8CGCA 1.925 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai LMR, UIK Allosteric, Type1 547 - 919 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 3BEAA 2.02 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai IXH Type1 547 - 921 0 None A933L Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 2I1MA 1.8 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai 5CN Type1 547 - 921 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 8JOTA 1.69 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai UKI Type1 543 - 914 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 8W1LA 2.26 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A1AE3 Type1 563 - 914 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 2I0VA 2.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 6C3 Type1 544 - 916 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 2I0YA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 5CN Type1 548 - 916 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 3KRJA 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai KRJ Type1 544 - 914 0 None S686S Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 3KRLA 2.4 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai KRL Type1 545 - 912 0 None S686S Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 7TNHA 2.7 Inactive DFGout‑BBAminus in-none out-in TYR APEdihe_iiiai APEdist_aaai I9W Type1 445 - 912 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 6T2WA 1.7 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai M9T Type1 547 - 916 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 3DPKA 1.95 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_niiai APEdist_aaai 8C5 Type1.5_Back 548 - 912 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 4HW7A 2.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 64M Type2 566 - 914 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 4R7HA 2.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai P31 Type2 544 - 915 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 4R7IA 2.75 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 567 - 914 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 6N33A 2.25 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 622 Type2 566 - 915 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 7MFCA 2.8 Inactive DFGout‑BBAminus in-none out-in TYR APEdihe_iiiai APEdist_aaai Z6V Type2 567 - 913 0 None C667T,C830S,C907T Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 6WXJA 2.62 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_nniai APEdist_aaai UF4 Type2 559 - 917 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 3LCOA 3.4 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_niiai APEdist_aaai LC0 Type2 551 - 915 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 6IG8A 1.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai A7O Type2 550 - 916 0 None S688A Macrophage colony-stimulating factor 1 receptor Homo sapiens
CSF1R_HUMAN 2OGVA 2.7 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 543 - 918 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens

TYR_CSF1R (Macrophage colony-stimulating factor 1 receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism