TYR_CSF1R (Macrophage colony-stimulating factor 1 receptor)

Total number of chains: 24
Active chains: 3
Uniprot: CSF1R_HUMAN
Kinase Domain Residues: 582 - 912
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 20 83.3% 3BEAA
DFGin BLAminus 3 12.5% AF-P07333-K1A
DFGout None 1 4.2% 2OGVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P07333-K1A 574 920 972.0 No_ligand No_ligand Active DFGin 6.652 13.682 BLAminus -129.73, -170.37 60.68, 61.76 -83.67, 16.28 293.33, 91.04 -60.56, -31.93 in-in in 7.342 Saltbr-in 2.65 HRD-in -85.18, -41.57 66.64, -3.1 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.0, 87.15 APE9-dihe-in -102.26, 148.85 APE8-dihe-in -77.64, 83.24 APE8-rot-na 35.68 APE67-dihe-in -68.32, -19.02 -47.18, -35.85 APE12-dist-na 14.318 APE11-dist-na 8.184 APE10-dist-na 10.165 APE9-dist-in 6.125 None None None AF2 -1.0 1.0 1.0 A 347 347 0 0 0 0 [[582, 912]] 1.0 AF-P07333-K1 TYR_CSF1R_HUMAN TYR 3.3e-104 353.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
AF-P07333-K3A 574 920 972.0 No_ligand No_ligand Active DFGin 6.497 13.412 BLAminus -113.28, -174.79 53.34, 69.41 -76.02, 10.88 289.88, 90.42 -60.78, -29.41 in-in in 7.86 Saltbr-in 2.778 HRD-in -86.66, -42.18 66.84, -3.51 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.07, 120.01 APE9-dihe-in -103.1, 151.08 APE8-dihe-in -79.62, 61.68 APE8-rot-na 36.46 APE67-dihe-in -71.97, -15.99 -50.03, -34.98 APE12-dist-na 14.388 APE11-dist-na 8.982 APE10-dist-na 12.374 APE9-dist-in 7.493 None None None AF2 -1.0 1.0 1.0 A 347 347 0 0 0 0 [[582, 912]] 1.0 AF-P07333-K3 TYR_CSF1R_HUMAN TYR 3.3e-104 353.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
3LCDA 558 913 972.0 BDY:923 Type1 Active DFGin 6.598 13.674 BLAminus -120.89, -173.4 58.72, 85.48 -99.9, 30.97 286.09, 74.59 -64.92, -35.13 in-in in 8.036 Saltbr-in 2.958 HRD-in -73.37, -48.08 71.11, 8.66 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.93, 134.38 APE9-dihe-in -126.88, 157.98 APE8-dihe-in -84.01, 73.99 APE8-rot-na 31.17 APE67-dihe-in -71.13, -10.19 -52.47, -40.67 APE12-dist-na 13.768 APE11-dist-na 8.039 APE10-dist-na 11.046 APE9-dist-in 6.944 None None None XRAY 2.5 0.218 0.265 A 329 290 7 0 0 2 [[582, 912]] 1.0 3lcd TYR_CSF1R_HUMAN TYR 5.7e-105 358.1 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
8CGCA 547 919 972.0 LMR:1001,UIK:1003 Allosteric,Type1 Inactive DFGout 12.283 11.461 BBAminus -166.09, 169.53 -82.64, 98.72 -99.93, 18.13 303.14, 136.75 -52.23, -39.39 in-in in 8.028 Saltbr-in 2.509 HRD-in -97.5, -55.66 81.57, -2.35 in-out-in SNCioi out-in ActLoopNT-out 16.009 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.38, 112.62 APE9-dihe-in -127.15, 140.97 APE8-dihe-in -78.3, 68.03 APE8-rot-na 35.2 APE67-dihe-in -63.28, -18.17 -54.75, -40.58 APE12-dist-na 18.161 APE11-dist-na 15.475 APE10-dist-na 12.841 APE9-dist-in 7.206 None None None XRAY 1.925 0.154 0.206 A 343 311 16 0 0 0 [[582, 912]] 1.0 8cgc TYR_CSF1R_HUMAN TYR 9.4e-105 356.4 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
3BEAA 547 921 972.0 IXH:60923 Type1 Inactive DFGout 11.985 11.572 BBAminus -170.71, 178.26 -91.71, 96.66 -101.53, 5.01 299.24, 149.1 -40.86, -54.12 in-in in 7.767 Saltbr-in 2.569 HRD-in -100.82, -52.06 74.1, 4.03 in-out-in SNCioi out-in ActLoopNT-out 15.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.48, 115.26 APE9-dihe-in -122.96, 139.34 APE8-dihe-in -74.35, 74.66 APE8-rot-na 5.79 APE67-dihe-in -69.62, -15.92 -56.05, -38.85 APE12-dist-na 17.823 APE11-dist-na 15.041 APE10-dist-na 12.774 APE9-dist-in 7.586 A933L None None XRAY 2.02 0.193 0.23 A 333 301 0 0 0 0 [[582, 912]] 1.0 3bea TYR_CSF1R_HUMAN TYR 6.9e-105 357.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
2I1MA 547 921 972.0 5CN:61000 Type1 Inactive DFGout 12.323 11.186 BBAminus -165.19, 169.45 -79.56, 109.66 -111.25, 8.35 308.47, 136.96 -49.04, -52.97 in-out in 8.119 Saltbr-out 3.612 HRD-in -87.64, -57.31 78.72, -7.69 out-out-in SNCooi out-in ActLoopNT-out 15.572 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.26, 115.95 APE9-dihe-in -121.8, 145.36 APE8-dihe-in -81.22, 65.36 APE8-rot-na 37.81 APE67-dihe-in -63.67, -16.66 -45.68, -43.82 APE12-dist-na 17.438 APE11-dist-na 14.158 APE10-dist-na 12.205 APE9-dist-in 7.505 None None None XRAY 1.8 0.25 0.282 A 333 311 7 0 0 0 [[582, 912]] 1.0 2i1m TYR_CSF1R_HUMAN TYR 1.9e-104 356.3 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
8JOTA 543 914 972.0 UKI:1001 Type1 Inactive DFGout 11.79 10.172 BBAminus -152.53, -164.7 -132.78, 111.2 -118.89, 28.73 306.09, 111.3 -53.84, -35.65 in-in in 7.947 Saltbr-in 2.677 HRD-in -85.99, -51.0 73.56, 2.04 in-out-in SNCioi out-in ActLoopNT-out 17.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.76, 114.95 APE9-dihe-in -118.98, 139.94 APE8-dihe-in -78.88, 70.02 APE8-rot-na 34.05 APE67-dihe-in -68.92, -12.46 -61.18, -37.88 APE12-dist-na 999.0 APE11-dist-na 16.081 APE10-dist-na 12.73 APE9-dist-in 7.639 C667T,C830S,C907T None None XRAY 1.69 0.18 0.207 A 354 306 26 0 0 1 [[582, 912]] 1.0 8jot TYR_CSF1R_HUMAN TYR 1.2e-104 356.1 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
8W1LA 563 914 972.0 A1AE3:61001 Type1 Inactive DFGout 15.806 10.52 BBAminus -146.99, -157.12 -159.28, 124.19 -69.24, -26.2 286.83, 92.53 59.16, -127.28 in-in in 7.231 Saltbr-in 3.275 HRD-in -68.82, -57.43 83.06, -5.47 in-out-in SNCioi out-in ActLoopNT-out 15.613 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.84, 113.0 APE9-dihe-in -125.78, 137.96 APE8-dihe-in -74.6, 68.05 APE8-rot-na 32.75 APE67-dihe-in -68.6, -14.57 -58.03, -36.27 APE12-dist-na 16.743 APE11-dist-na 14.158 APE10-dist-na 11.761 APE9-dist-in 7.618 None None None XRAY 2.26 0.178 0.226 A 333 282 17 0 0 0 [[582, 912]] 1.0 8w1l TYR_CSF1R_HUMAN TYR 2.4e-105 358.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
2I0VA 544 916 972.0 6C3:61000 Type1 Inactive DFGout 13.504 11.48 BBAminus -168.21, -167.69 -128.77, 119.1 -107.57, 31.73 309.28, 148.42 -48.69, -53.43 in-in in 8.14 Saltbr-in 2.5 HRD-in -94.88, -57.16 74.34, 9.83 in-out-in SNCioi out-in ActLoopNT-out 17.554 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.11, 117.12 APE9-dihe-in -126.06, 134.07 APE8-dihe-in -76.67, 76.91 APE8-rot-na 35.75 APE67-dihe-in -49.64, -16.24 -49.2, -58.15 APE12-dist-na 999.0 APE11-dist-na 14.44 APE10-dist-na 12.011 APE9-dist-in 6.921 None None None XRAY 2.8 0.266 0.296 A 335 303 17 0 0 1 [[582, 912]] 1.0 2i0v TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
2I0YA 548 916 972.0 5CN:61000 Type1 Inactive DFGout 12.282 11.344 BBAminus -165.97, 175.75 -91.87, 106.47 -107.9, 6.58 310.92, 141.83 -49.48, -41.66 in-in in 7.902 Saltbr-in 2.847 HRD-in -90.07, -51.41 71.45, -1.27 in-out-in SNCioi out-in ActLoopNT-out 15.369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.69, 108.9 APE9-dihe-in -117.45, 142.95 APE8-dihe-in -79.32, 69.94 APE8-rot-na 34.17 APE67-dihe-in -65.64, -10.36 -48.82, -42.67 APE12-dist-na 999.0 APE11-dist-na 14.779 APE10-dist-na 12.255 APE9-dist-in 7.569 None None None XRAY 1.9 0.246 0.263 A 335 289 17 0 0 1 [[582, 912]] 1.0 2i0y TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
3KRJA 544 914 972.0 KRJ:60923 Type1 Inactive DFGout 12.654 11.56 BBAminus -160.74, -164.14 -134.35, 114.03 -119.51, 31.15 323.45, 126.06 -51.17, -38.45 in-in in 8.109 Saltbr-in 2.923 HRD-in -92.52, -53.99 73.92, 1.01 in-out-in SNCioi out-in ActLoopNT-out 17.993 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.55, 112.52 APE9-dihe-in -120.97, 136.63 APE8-dihe-in -76.63, 70.88 APE8-rot-na 32.13 APE67-dihe-in -71.96, -14.95 -58.2, -33.55 APE12-dist-na 999.0 APE11-dist-na 14.789 APE10-dist-na 12.0 APE9-dist-in 7.1 S686S None None XRAY 2.1 0.213 0.26 A 335 296 13 0 0 1 [[582, 912]] 1.0 3krj TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
3KRLA 545 912 972.0 KRL:60001 Type1 Inactive DFGout 12.293 11.151 BBAminus -166.35, -165.37 -127.99, 118.93 -124.46, 33.48 316.96, 119.52 -67.42, -24.77 in-out in 7.886 Saltbr-out 3.793 HRD-in -78.73, -49.78 74.65, -2.34 out-out-in SNCooi out-in ActLoopNT-out 18.286 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.45, 118.3 APE9-dihe-in -118.9, 129.88 APE8-dihe-in -81.75, 77.76 APE8-rot-na 21.26 APE67-dihe-in -69.51, -13.73 -62.53, -33.39 APE12-dist-na 999.0 APE11-dist-na 15.527 APE10-dist-na 12.024 APE9-dist-in 7.02 S686S None None XRAY 2.4 0.212 0.264 A 335 276 14 0 0 1 [[582, 912]] 1.0 3krl TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
7TNHA 445 912 972.0 I9W:61006 Type1 Inactive DFGout 16.947 10.868 BBAminus -129.25, -154.67 -161.93, 107.67 -50.13, -40.9 281.82, 79.54 46.58, -105.28 in-none in 8.015 Saltbr-none 999.0 HRD-in -102.14, -63.26 85.99, 0.49 none-out-in SNCnoi out-in ActLoopNT-out 16.437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -137.22, 114.76 APE9-dihe-in -121.57, 150.84 APE8-dihe-in -80.48, 71.48 APE8-rot-na 29.96 APE67-dihe-in -61.46, -10.7 -53.89, -41.9 APE12-dist-na 15.404 APE11-dist-na 13.501 APE10-dist-na 12.465 APE9-dist-in 7.087 None None None XRAY 2.7 0.217 0.269 A 338 276 16 0 0 0 [[582, 912]] 1.0 7tnh TYR_CSF1R_HUMAN TYR 2.6e-105 357.4 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
6T2WA 547 916 972.0 M9T:1001 Type1 Inactive DFGout 12.136 11.148 BBAminus -164.58, 171.46 -91.93, 101.05 -104.49, 13.89 310.17, 129.77 -61.14, -26.11 in-in in 7.616 Saltbr-in 3.224 HRD-in -90.49, -51.6 71.37, 4.6 in-out-in SNCioi out-in ActLoopNT-out 15.313 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.57, 112.16 APE9-dihe-in -119.75, 141.57 APE8-dihe-in -83.48, 72.13 APE8-rot-na 31.27 APE67-dihe-in -65.36, -14.22 -52.69, -42.68 APE12-dist-na 16.023 APE11-dist-na 14.048 APE10-dist-na 12.076 APE9-dist-in 7.8 None None None XRAY 1.7 0.167 0.187 A 332 304 18 0 0 0 [[582, 912]] 1.0 6t2w TYR_CSF1R_HUMAN TYR 8.4e-105 355.9 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
3DPKA 548 912 972.0 8C5:60923 Type1.5_Back Inactive DFGout 12.137 11.351 BBAminus -161.74, 175.5 -97.09, 95.74 -103.53, 13.11 311.01, 136.38 -61.02, -28.45 in-in in 8.05 Saltbr-in 2.493 HRD-in -91.0, -54.03 74.08, 5.35 in-out-none SNCion out-none ActLoopNT-out 15.071 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.89 APE9-dihe-in -125.42, 145.91 APE8-dihe-in -84.54, 71.05 APE8-rot-na 21.52 APE67-dihe-in -67.83, -12.02 -59.26, -36.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.229 APE9-dist-in 7.556 None None None XRAY 1.95 0.192 0.244 A 335 275 20 0 0 4 [[582, 912]] 1.0 3dpk TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
4HW7A 566 914 972.0 64M:1001 Type2 Inactive DFGout 16.385 10.156 BBAminus -132.56, -168.7 -149.08, 104.78 -59.16, -36.89 279.18, 73.28 48.86, -107.65 in-in in 8.123 Saltbr-in 2.697 HRD-in -76.83, -41.96 64.24, 7.11 in-out-in SNCioi out-in ActLoopNT-out 16.569 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.87, 111.54 APE9-dihe-in -119.9, 147.75 APE8-dihe-in -79.43, 66.3 APE8-rot-na 30.55 APE67-dihe-in -66.0, -13.84 -47.5, -43.26 APE12-dist-na 16.948 APE11-dist-na 13.954 APE10-dist-na 11.729 APE9-dist-in 7.482 C667T,C830S,C907T None None XRAY 2.9 0.222 0.267 A 343 289 14 0 0 0 [[582, 912]] 1.0 4hw7 TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
4R7HA 544 915 972.0 P31:1001 Type2 Inactive DFGout 16.491 10.413 BBAminus -137.9, -155.69 -162.12, 119.57 -64.15, -40.2 282.23, 73.06 54.17, -114.92 in-in in 7.699 Saltbr-in 2.648 HRD-in -68.38, -55.54 76.9, -0.78 in-out-in SNCioi out-in ActLoopNT-out 16.518 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.4, 109.67 APE9-dihe-in -116.59, 147.76 APE8-dihe-in -79.44, 59.17 APE8-rot-na 357.12 APE67-dihe-in -68.54, -10.9 -44.81, -43.23 APE12-dist-na 17.553 APE11-dist-na 14.161 APE10-dist-na 11.7 APE9-dist-in 7.655 C667T,C830S,C907T None None XRAY 2.8 0.222 0.248 A 343 308 13 0 0 0 [[582, 912]] 1.0 4r7h TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
4R7IA 567 914 972.0 STI:1001 Type2 Inactive DFGout 16.334 10.491 BBAminus -135.43, -165.69 -154.33, 113.23 -65.43, -32.31 273.23, 63.99 51.24, -116.49 in-in in 7.877 Saltbr-in 2.852 HRD-in -76.35, -49.6 69.77, 4.78 in-out-in SNCioi out-in ActLoopNT-out 16.24 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.49, 117.23 APE9-dihe-in -119.6, 145.64 APE8-dihe-in -75.5, 67.23 APE8-rot-na 28.71 APE67-dihe-in -66.69, -12.1 -54.21, -40.35 APE12-dist-na 17.192 APE11-dist-na 13.453 APE10-dist-na 12.171 APE9-dist-in 7.521 C667T,C830S,C907T None None XRAY 2.75 0.202 0.236 A 343 290 12 0 0 0 [[582, 912]] 1.0 4r7i TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
6N33A 566 915 972.0 622:1001 Type2 Inactive DFGout 16.341 10.339 BBAminus -132.0, -158.32 -158.9, 108.08 -60.21, -36.59 274.09, 79.54 61.38, -122.72 in-in in 7.702 Saltbr-in 2.542 HRD-in -77.1, -53.9 82.11, -3.56 in-out-in SNCioi out-in ActLoopNT-out 16.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.34, 116.49 APE9-dihe-in -122.79, 144.29 APE8-dihe-in -78.43, 67.94 APE8-rot-na 34.95 APE67-dihe-in -65.85, -15.22 -54.67, -41.89 APE12-dist-na 17.259 APE11-dist-na 13.374 APE10-dist-na 11.759 APE9-dist-in 7.608 C667T,C830S,C907T None None XRAY 2.25 0.183 0.22 A 343 292 12 0 0 0 [[582, 912]] 1.0 6n33 TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
7MFCA 567 913 972.0 Z6V:1000 Type2 Inactive DFGout 15.928 10.519 BBAminus -135.55, -167.98 -155.76, 112.66 -68.84, -24.79 285.05, 87.17 43.7, -115.13 in-none in 7.663 Saltbr-none 999.0 HRD-in -63.24, -58.73 66.97, 13.97 none-out-in SNCnoi out-in ActLoopNT-out 15.934 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.13, 127.12 APE9-dihe-in -125.22, 138.0 APE8-dihe-in -72.69, 76.55 APE8-rot-na 31.26 APE67-dihe-in -66.73, -12.06 -60.97, -44.75 APE12-dist-na 15.964 APE11-dist-na 12.345 APE10-dist-na 11.39 APE9-dist-in 7.624 C667T,C830S,C907T None None XRAY 2.8 0.229 0.256 A 343 287 14 0 0 0 [[582, 912]] 1.0 7mfc TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
6WXJA 559 917 972.0 UF4:61001 Type2 Inactive DFGout 16.356 10.102 BBAminus -153.38, -171.66 -155.83, 116.27 -70.08, -22.63 276.47, 93.24 47.08, -116.23 in-in in 7.699 Saltbr-in 2.866 HRD-in -89.54, -47.16 78.58, -19.67 in-out-none SNCion out-none ActLoopNT-out 16.937 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.14 APE8-dihe-in -86.07, 72.73 APE8-rot-na 25.73 APE67-dihe-in -56.92, -18.89 -50.97, -46.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.479 None None None XRAY 2.62 0.185 0.272 A 332 281 4 0 0 3 [[582, 912]] 1.0 6wxj TYR_CSF1R_HUMAN TYR 5.1e-105 357.4 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
3LCOA 551 915 972.0 LC0:999 Type2 Inactive DFGout 15.576 9.768 BBAminus -158.9, -153.99 -154.53, 102.62 -48.64, -46.0 276.13, 95.55 73.85, -121.13 in-in in 8.324 Saltbr-in 2.762 HRD-in -86.35, -49.41 72.13, 5.18 in-out-none SNCion out-none ActLoopNT-out 16.969 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.87 APE9-dihe-in -130.4, 150.76 APE8-dihe-in -81.61, 83.67 APE8-rot-na 31.94 APE67-dihe-in -67.9, -20.36 -59.89, -42.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.389 APE9-dist-in 7.224 None None None XRAY 3.4 0.247 0.289 A 324 293 18 0 0 4 [[582, 912]] 1.0 3lco TYR_CSF1R_HUMAN TYR 7.7e-105 355.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
6IG8A 550 916 972.0 A7O:1004 Type2 Inactive DFGout 15.697 10.29 BBAminus -147.52, -154.16 -149.63, 119.34 -63.16, -29.4 276.12, 92.24 57.56, -123.2 in-in in 7.407 Saltbr-in 2.52 HRD-in -74.2, -50.69 74.97, -3.25 in-out-in SNCioi out-in ActLoopNT-out 16.85 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.15, 115.89 APE9-dihe-in -126.26, 145.72 APE8-dihe-in -80.96, 54.8 APE8-rot-na 37.07 APE67-dihe-in -69.77, -14.73 -41.8, -38.63 APE12-dist-na 16.635 APE11-dist-na 14.036 APE10-dist-na 11.689 APE9-dist-in 7.516 S688A None None XRAY 1.8 0.158 0.192 A 324 301 13 0 0 0 [[582, 912]] 1.0 6ig8 TYR_CSF1R_HUMAN TYR 7.7e-105 355.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
2OGVA 543 918 972.0 No_ligand No_ligand Inactive DFGout 16.634 8.771 None -140.77, -152.27 -130.9, 121.71 -114.98, 22.59 221.6, 52.29 -62.71, -27.02 in-out in 8.181 Saltbr-out 3.892 HRD-in -68.73, -51.12 73.85, 4.71 out-out-in SNCooi out-in ActLoopNT-out 18.53 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.97, 103.89 APE9-dihe-in -114.14, 148.22 APE8-dihe-in -76.82, 73.53 APE8-rot-na 28.42 APE67-dihe-in -66.15, -20.25 -59.71, -34.88 APE12-dist-na 20.298 APE11-dist-na 15.681 APE10-dist-na 13.632 APE9-dist-in 7.317 None None None XRAY 2.7 0.21 0.279 A 317 317 0 0 0 0 [[582, 912]] 1.0 2ogv TYR_CSF1R_HUMAN TYR 5e-105 356.6 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor

TYR_CSF1R (Macrophage colony-stimulating factor 1 receptor)

Total number of chains: 24
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 20 83.3% 3BEAA
DFGin BLAminus 3 12.5% AF-P07333-K1A
DFGout None 1 4.2% 2OGVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CSF1R_HUMAN AF-P07333-K1A P07333 574 920 972.0 No_ligand No_ligand Active DFGin 6.652 13.682 BLAminus -129.73, -170.37 60.68, 61.76 -83.67, 16.28 293.33, 91.04 -60.56, -31.93 in-in in 7.342 Saltbr-in 2.65 HRD-in -85.18, -41.57 66.64, -3.1 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -79.0, 87.15 APE9-dihe-in -102.26, 148.85 APE8-dihe-in -77.64, 83.24 APE8-rot-na 35.68 APE67-dihe-in -68.32, -19.02 -47.18, -35.85 APE12-dist-na 14.318 APE11-dist-na 8.184 APE10-dist-na 10.165 APE9-dist-in 6.125 None None None AF2 -1.0 1.0 1.0 A 347 347 0 0 0 0 [[582, 912]] 1.0 AF-P07333-K1 Homo sapiens TYR_CSF1R_HUMAN TYR 3.3e-104 353.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN AF-P07333-K3A P07333 574 920 972.0 No_ligand No_ligand Active DFGin 6.497 13.412 BLAminus -113.28, -174.79 53.34, 69.41 -76.02, 10.88 289.88, 90.42 -60.78, -29.41 in-in in 7.86 Saltbr-in 2.778 HRD-in -86.66, -42.18 66.84, -3.51 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.07, 120.01 APE9-dihe-in -103.1, 151.08 APE8-dihe-in -79.62, 61.68 APE8-rot-na 36.46 APE67-dihe-in -71.97, -15.99 -50.03, -34.98 APE12-dist-na 14.388 APE11-dist-na 8.982 APE10-dist-na 12.374 APE9-dist-in 7.493 None None None AF2 -1.0 1.0 1.0 A 347 347 0 0 0 0 [[582, 912]] 1.0 AF-P07333-K3 Homo sapiens TYR_CSF1R_HUMAN TYR 3.3e-104 353.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 3LCDA P07333 558 913 972.0 BDY:923 Type1 Active DFGin 6.598 13.674 BLAminus -120.89, -173.4 58.72, 85.48 -99.9, 30.97 286.09, 74.59 -64.92, -35.13 in-in in 8.036 Saltbr-in 2.958 HRD-in -73.37, -48.08 71.11, 8.66 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -63.93, 134.38 APE9-dihe-in -126.88, 157.98 APE8-dihe-in -84.01, 73.99 APE8-rot-na 31.17 APE67-dihe-in -71.13, -10.19 -52.47, -40.67 APE12-dist-na 13.768 APE11-dist-na 8.039 APE10-dist-na 11.046 APE9-dist-in 6.944 None None None XRAY 2.5 0.218 0.265 A 329 290 7 0 0 2 [[582, 912]] 1.0 3lcd Homo sapiens TYR_CSF1R_HUMAN TYR 5.7e-105 358.1 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 8CGCA P07333 547 919 972.0 LMR:1001,UIK:1003 Allosteric,Type1 Inactive DFGout 12.283 11.461 BBAminus -166.09, 169.53 -82.64, 98.72 -99.93, 18.13 303.14, 136.75 -52.23, -39.39 in-in in 8.028 Saltbr-in 2.509 HRD-in -97.5, -55.66 81.57, -2.35 in-out-in SNCioi out-in ActLoopNT-out 16.009 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.38, 112.62 APE9-dihe-in -127.15, 140.97 APE8-dihe-in -78.3, 68.03 APE8-rot-na 35.2 APE67-dihe-in -63.28, -18.17 -54.75, -40.58 APE12-dist-na 18.161 APE11-dist-na 15.475 APE10-dist-na 12.841 APE9-dist-in 7.206 None None None XRAY 1.925 0.154 0.206 A 343 311 16 0 0 0 [[582, 912]] 1.0 8cgc Homo sapiens TYR_CSF1R_HUMAN TYR 9.4e-105 356.4 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 3BEAA P07333 547 921 972.0 IXH:60923 Type1 Inactive DFGout 11.985 11.572 BBAminus -170.71, 178.26 -91.71, 96.66 -101.53, 5.01 299.24, 149.1 -40.86, -54.12 in-in in 7.767 Saltbr-in 2.569 HRD-in -100.82, -52.06 74.1, 4.03 in-out-in SNCioi out-in ActLoopNT-out 15.807 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -133.48, 115.26 APE9-dihe-in -122.96, 139.34 APE8-dihe-in -74.35, 74.66 APE8-rot-na 5.79 APE67-dihe-in -69.62, -15.92 -56.05, -38.85 APE12-dist-na 17.823 APE11-dist-na 15.041 APE10-dist-na 12.774 APE9-dist-in 7.586 A933L None None XRAY 2.02 0.193 0.23 A 333 301 0 0 0 0 [[582, 912]] 1.0 3bea Homo sapiens TYR_CSF1R_HUMAN TYR 6.9e-105 357.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 2I1MA P07333 547 921 972.0 5CN:61000 Type1 Inactive DFGout 12.323 11.186 BBAminus -165.19, 169.45 -79.56, 109.66 -111.25, 8.35 308.47, 136.96 -49.04, -52.97 in-out in 8.119 Saltbr-out 3.612 HRD-in -87.64, -57.31 78.72, -7.69 out-out-in SNCooi out-in ActLoopNT-out 15.572 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.26, 115.95 APE9-dihe-in -121.8, 145.36 APE8-dihe-in -81.22, 65.36 APE8-rot-na 37.81 APE67-dihe-in -63.67, -16.66 -45.68, -43.82 APE12-dist-na 17.438 APE11-dist-na 14.158 APE10-dist-na 12.205 APE9-dist-in 7.505 None None None XRAY 1.8 0.25 0.282 A 333 311 7 0 0 0 [[582, 912]] 1.0 2i1m Homo sapiens TYR_CSF1R_HUMAN TYR 1.9e-104 356.3 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 8JOTA P07333 543 914 972.0 UKI:1001 Type1 Inactive DFGout 11.79 10.172 BBAminus -152.53, -164.7 -132.78, 111.2 -118.89, 28.73 306.09, 111.3 -53.84, -35.65 in-in in 7.947 Saltbr-in 2.677 HRD-in -85.99, -51.0 73.56, 2.04 in-out-in SNCioi out-in ActLoopNT-out 17.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.76, 114.95 APE9-dihe-in -118.98, 139.94 APE8-dihe-in -78.88, 70.02 APE8-rot-na 34.05 APE67-dihe-in -68.92, -12.46 -61.18, -37.88 APE12-dist-na 999.0 APE11-dist-na 16.081 APE10-dist-na 12.73 APE9-dist-in 7.639 C667T,C830S,C907T None None XRAY 1.69 0.18 0.207 A 354 306 26 0 0 1 [[582, 912]] 1.0 8jot Homo sapiens TYR_CSF1R_HUMAN TYR 1.2e-104 356.1 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 8W1LA P07333 563 914 972.0 A1AE3:61001 Type1 Inactive DFGout 15.806 10.52 BBAminus -146.99, -157.12 -159.28, 124.19 -69.24, -26.2 286.83, 92.53 59.16, -127.28 in-in in 7.231 Saltbr-in 3.275 HRD-in -68.82, -57.43 83.06, -5.47 in-out-in SNCioi out-in ActLoopNT-out 15.613 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.84, 113.0 APE9-dihe-in -125.78, 137.96 APE8-dihe-in -74.6, 68.05 APE8-rot-na 32.75 APE67-dihe-in -68.6, -14.57 -58.03, -36.27 APE12-dist-na 16.743 APE11-dist-na 14.158 APE10-dist-na 11.761 APE9-dist-in 7.618 None None None XRAY 2.26 0.178 0.226 A 333 282 17 0 0 0 [[582, 912]] 1.0 8w1l Homo sapiens TYR_CSF1R_HUMAN TYR 2.4e-105 358.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 2I0VA P07333 544 916 972.0 6C3:61000 Type1 Inactive DFGout 13.504 11.48 BBAminus -168.21, -167.69 -128.77, 119.1 -107.57, 31.73 309.28, 148.42 -48.69, -53.43 in-in in 8.14 Saltbr-in 2.5 HRD-in -94.88, -57.16 74.34, 9.83 in-out-in SNCioi out-in ActLoopNT-out 17.554 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.11, 117.12 APE9-dihe-in -126.06, 134.07 APE8-dihe-in -76.67, 76.91 APE8-rot-na 35.75 APE67-dihe-in -49.64, -16.24 -49.2, -58.15 APE12-dist-na 999.0 APE11-dist-na 14.44 APE10-dist-na 12.011 APE9-dist-in 6.921 None None None XRAY 2.8 0.266 0.296 A 335 303 17 0 0 1 [[582, 912]] 1.0 2i0v Homo sapiens TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 2I0YA P07333 548 916 972.0 5CN:61000 Type1 Inactive DFGout 12.282 11.344 BBAminus -165.97, 175.75 -91.87, 106.47 -107.9, 6.58 310.92, 141.83 -49.48, -41.66 in-in in 7.902 Saltbr-in 2.847 HRD-in -90.07, -51.41 71.45, -1.27 in-out-in SNCioi out-in ActLoopNT-out 15.369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.69, 108.9 APE9-dihe-in -117.45, 142.95 APE8-dihe-in -79.32, 69.94 APE8-rot-na 34.17 APE67-dihe-in -65.64, -10.36 -48.82, -42.67 APE12-dist-na 999.0 APE11-dist-na 14.779 APE10-dist-na 12.255 APE9-dist-in 7.569 None None None XRAY 1.9 0.246 0.263 A 335 289 17 0 0 1 [[582, 912]] 1.0 2i0y Homo sapiens TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 3KRJA P07333 544 914 972.0 KRJ:60923 Type1 Inactive DFGout 12.654 11.56 BBAminus -160.74, -164.14 -134.35, 114.03 -119.51, 31.15 323.45, 126.06 -51.17, -38.45 in-in in 8.109 Saltbr-in 2.923 HRD-in -92.52, -53.99 73.92, 1.01 in-out-in SNCioi out-in ActLoopNT-out 17.993 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.55, 112.52 APE9-dihe-in -120.97, 136.63 APE8-dihe-in -76.63, 70.88 APE8-rot-na 32.13 APE67-dihe-in -71.96, -14.95 -58.2, -33.55 APE12-dist-na 999.0 APE11-dist-na 14.789 APE10-dist-na 12.0 APE9-dist-in 7.1 S686S None None XRAY 2.1 0.213 0.26 A 335 296 13 0 0 1 [[582, 912]] 1.0 3krj Homo sapiens TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 3KRLA P07333 545 912 972.0 KRL:60001 Type1 Inactive DFGout 12.293 11.151 BBAminus -166.35, -165.37 -127.99, 118.93 -124.46, 33.48 316.96, 119.52 -67.42, -24.77 in-out in 7.886 Saltbr-out 3.793 HRD-in -78.73, -49.78 74.65, -2.34 out-out-in SNCooi out-in ActLoopNT-out 18.286 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.45, 118.3 APE9-dihe-in -118.9, 129.88 APE8-dihe-in -81.75, 77.76 APE8-rot-na 21.26 APE67-dihe-in -69.51, -13.73 -62.53, -33.39 APE12-dist-na 999.0 APE11-dist-na 15.527 APE10-dist-na 12.024 APE9-dist-in 7.02 S686S None None XRAY 2.4 0.212 0.264 A 335 276 14 0 0 1 [[582, 912]] 1.0 3krl Homo sapiens TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 7TNHA P07333 445 912 972.0 I9W:61006 Type1 Inactive DFGout 16.947 10.868 BBAminus -129.25, -154.67 -161.93, 107.67 -50.13, -40.9 281.82, 79.54 46.58, -105.28 in-none in 8.015 Saltbr-none 999.0 HRD-in -102.14, -63.26 85.99, 0.49 none-out-in SNCnoi out-in ActLoopNT-out 16.437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -137.22, 114.76 APE9-dihe-in -121.57, 150.84 APE8-dihe-in -80.48, 71.48 APE8-rot-na 29.96 APE67-dihe-in -61.46, -10.7 -53.89, -41.9 APE12-dist-na 15.404 APE11-dist-na 13.501 APE10-dist-na 12.465 APE9-dist-in 7.087 None None None XRAY 2.7 0.217 0.269 A 338 276 16 0 0 0 [[582, 912]] 1.0 7tnh Homo sapiens TYR_CSF1R_HUMAN TYR 2.6e-105 357.4 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 6T2WA P07333 547 916 972.0 M9T:1001 Type1 Inactive DFGout 12.136 11.148 BBAminus -164.58, 171.46 -91.93, 101.05 -104.49, 13.89 310.17, 129.77 -61.14, -26.11 in-in in 7.616 Saltbr-in 3.224 HRD-in -90.49, -51.6 71.37, 4.6 in-out-in SNCioi out-in ActLoopNT-out 15.313 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.57, 112.16 APE9-dihe-in -119.75, 141.57 APE8-dihe-in -83.48, 72.13 APE8-rot-na 31.27 APE67-dihe-in -65.36, -14.22 -52.69, -42.68 APE12-dist-na 16.023 APE11-dist-na 14.048 APE10-dist-na 12.076 APE9-dist-in 7.8 None None None XRAY 1.7 0.167 0.187 A 332 304 18 0 0 0 [[582, 912]] 1.0 6t2w Homo sapiens TYR_CSF1R_HUMAN TYR 8.4e-105 355.9 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 3DPKA P07333 548 912 972.0 8C5:60923 Type1.5_Back Inactive DFGout 12.137 11.351 BBAminus -161.74, 175.5 -97.09, 95.74 -103.53, 13.11 311.01, 136.38 -61.02, -28.45 in-in in 8.05 Saltbr-in 2.493 HRD-in -91.0, -54.03 74.08, 5.35 in-out-none SNCion out-none ActLoopNT-out 15.071 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 112.89 APE9-dihe-in -125.42, 145.91 APE8-dihe-in -84.54, 71.05 APE8-rot-na 21.52 APE67-dihe-in -67.83, -12.02 -59.26, -36.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.229 APE9-dist-in 7.556 None None None XRAY 1.95 0.192 0.244 A 335 275 20 0 0 4 [[582, 912]] 1.0 3dpk Homo sapiens TYR_CSF1R_HUMAN TYR 2.5e-105 359.2 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 4HW7A P07333 566 914 972.0 64M:1001 Type2 Inactive DFGout 16.385 10.156 BBAminus -132.56, -168.7 -149.08, 104.78 -59.16, -36.89 279.18, 73.28 48.86, -107.65 in-in in 8.123 Saltbr-in 2.697 HRD-in -76.83, -41.96 64.24, 7.11 in-out-in SNCioi out-in ActLoopNT-out 16.569 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.87, 111.54 APE9-dihe-in -119.9, 147.75 APE8-dihe-in -79.43, 66.3 APE8-rot-na 30.55 APE67-dihe-in -66.0, -13.84 -47.5, -43.26 APE12-dist-na 16.948 APE11-dist-na 13.954 APE10-dist-na 11.729 APE9-dist-in 7.482 C667T,C830S,C907T None None XRAY 2.9 0.222 0.267 A 343 289 14 0 0 0 [[582, 912]] 1.0 4hw7 Homo sapiens TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 4R7HA P07333 544 915 972.0 P31:1001 Type2 Inactive DFGout 16.491 10.413 BBAminus -137.9, -155.69 -162.12, 119.57 -64.15, -40.2 282.23, 73.06 54.17, -114.92 in-in in 7.699 Saltbr-in 2.648 HRD-in -68.38, -55.54 76.9, -0.78 in-out-in SNCioi out-in ActLoopNT-out 16.518 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.4, 109.67 APE9-dihe-in -116.59, 147.76 APE8-dihe-in -79.44, 59.17 APE8-rot-na 357.12 APE67-dihe-in -68.54, -10.9 -44.81, -43.23 APE12-dist-na 17.553 APE11-dist-na 14.161 APE10-dist-na 11.7 APE9-dist-in 7.655 C667T,C830S,C907T None None XRAY 2.8 0.222 0.248 A 343 308 13 0 0 0 [[582, 912]] 1.0 4r7h Homo sapiens TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 4R7IA P07333 567 914 972.0 STI:1001 Type2 Inactive DFGout 16.334 10.491 BBAminus -135.43, -165.69 -154.33, 113.23 -65.43, -32.31 273.23, 63.99 51.24, -116.49 in-in in 7.877 Saltbr-in 2.852 HRD-in -76.35, -49.6 69.77, 4.78 in-out-in SNCioi out-in ActLoopNT-out 16.24 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.49, 117.23 APE9-dihe-in -119.6, 145.64 APE8-dihe-in -75.5, 67.23 APE8-rot-na 28.71 APE67-dihe-in -66.69, -12.1 -54.21, -40.35 APE12-dist-na 17.192 APE11-dist-na 13.453 APE10-dist-na 12.171 APE9-dist-in 7.521 C667T,C830S,C907T None None XRAY 2.75 0.202 0.236 A 343 290 12 0 0 0 [[582, 912]] 1.0 4r7i Homo sapiens TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 6N33A P07333 566 915 972.0 622:1001 Type2 Inactive DFGout 16.341 10.339 BBAminus -132.0, -158.32 -158.9, 108.08 -60.21, -36.59 274.09, 79.54 61.38, -122.72 in-in in 7.702 Saltbr-in 2.542 HRD-in -77.1, -53.9 82.11, -3.56 in-out-in SNCioi out-in ActLoopNT-out 16.42 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.34, 116.49 APE9-dihe-in -122.79, 144.29 APE8-dihe-in -78.43, 67.94 APE8-rot-na 34.95 APE67-dihe-in -65.85, -15.22 -54.67, -41.89 APE12-dist-na 17.259 APE11-dist-na 13.374 APE10-dist-na 11.759 APE9-dist-in 7.608 C667T,C830S,C907T None None XRAY 2.25 0.183 0.22 A 343 292 12 0 0 0 [[582, 912]] 1.0 6n33 Homo sapiens TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 7MFCA P07333 567 913 972.0 Z6V:1000 Type2 Inactive DFGout 15.928 10.519 BBAminus -135.55, -167.98 -155.76, 112.66 -68.84, -24.79 285.05, 87.17 43.7, -115.13 in-none in 7.663 Saltbr-none 999.0 HRD-in -63.24, -58.73 66.97, 13.97 none-out-in SNCnoi out-in ActLoopNT-out 15.934 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.13, 127.12 APE9-dihe-in -125.22, 138.0 APE8-dihe-in -72.69, 76.55 APE8-rot-na 31.26 APE67-dihe-in -66.73, -12.06 -60.97, -44.75 APE12-dist-na 15.964 APE11-dist-na 12.345 APE10-dist-na 11.39 APE9-dist-in 7.624 C667T,C830S,C907T None None XRAY 2.8 0.229 0.256 A 343 287 14 0 0 0 [[582, 912]] 1.0 7mfc Homo sapiens TYR_CSF1R_HUMAN TYR 7.9e-105 356.7 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 6WXJA P07333 559 917 972.0 UF4:61001 Type2 Inactive DFGout 16.356 10.102 BBAminus -153.38, -171.66 -155.83, 116.27 -70.08, -22.63 276.47, 93.24 47.08, -116.23 in-in in 7.699 Saltbr-in 2.866 HRD-in -89.54, -47.16 78.58, -19.67 in-out-none SNCion out-none ActLoopNT-out 16.937 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.14 APE8-dihe-in -86.07, 72.73 APE8-rot-na 25.73 APE67-dihe-in -56.92, -18.89 -50.97, -46.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.479 None None None XRAY 2.62 0.185 0.272 A 332 281 4 0 0 3 [[582, 912]] 1.0 6wxj Homo sapiens TYR_CSF1R_HUMAN TYR 5.1e-105 357.4 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 3LCOA P07333 551 915 972.0 LC0:999 Type2 Inactive DFGout 15.576 9.768 BBAminus -158.9, -153.99 -154.53, 102.62 -48.64, -46.0 276.13, 95.55 73.85, -121.13 in-in in 8.324 Saltbr-in 2.762 HRD-in -86.35, -49.41 72.13, 5.18 in-out-none SNCion out-none ActLoopNT-out 16.969 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.87 APE9-dihe-in -130.4, 150.76 APE8-dihe-in -81.61, 83.67 APE8-rot-na 31.94 APE67-dihe-in -67.9, -20.36 -59.89, -42.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.389 APE9-dist-in 7.224 None None None XRAY 3.4 0.247 0.289 A 324 293 18 0 0 4 [[582, 912]] 1.0 3lco Homo sapiens TYR_CSF1R_HUMAN TYR 7.7e-105 355.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 6IG8A P07333 550 916 972.0 A7O:1004 Type2 Inactive DFGout 15.697 10.29 BBAminus -147.52, -154.16 -149.63, 119.34 -63.16, -29.4 276.12, 92.24 57.56, -123.2 in-in in 7.407 Saltbr-in 2.52 HRD-in -74.2, -50.69 74.97, -3.25 in-out-in SNCioi out-in ActLoopNT-out 16.85 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.15, 115.89 APE9-dihe-in -126.26, 145.72 APE8-dihe-in -80.96, 54.8 APE8-rot-na 37.07 APE67-dihe-in -69.77, -14.73 -41.8, -38.63 APE12-dist-na 16.635 APE11-dist-na 14.036 APE10-dist-na 11.689 APE9-dist-in 7.516 S688A None None XRAY 1.8 0.158 0.192 A 324 301 13 0 0 0 [[582, 912]] 1.0 6ig8 Homo sapiens TYR_CSF1R_HUMAN TYR 7.7e-105 355.8 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor
CSF1R_HUMAN 2OGVA P07333 543 918 972.0 No_ligand No_ligand Inactive DFGout 16.634 8.771 None -140.77, -152.27 -130.9, 121.71 -114.98, 22.59 221.6, 52.29 -62.71, -27.02 in-out in 8.181 Saltbr-out 3.892 HRD-in -68.73, -51.12 73.85, 4.71 out-out-in SNCooi out-in ActLoopNT-out 18.53 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.97, 103.89 APE9-dihe-in -114.14, 148.22 APE8-dihe-in -76.82, 73.53 APE8-rot-na 28.42 APE67-dihe-in -66.15, -20.25 -59.71, -34.88 APE12-dist-na 20.298 APE11-dist-na 15.681 APE10-dist-na 13.632 APE9-dist-in 7.317 None None None XRAY 2.7 0.21 0.279 A 317 317 0 0 0 0 [[582, 912]] 1.0 2ogv Homo sapiens TYR_CSF1R_HUMAN TYR 5e-105 356.6 1 260 260 795 796 797 799 801 616 633 637 775 777 776 778 837 825 820 819 818 817 816 815 814 664 Macrophage colony-stimulating factor 1 receptor

TYR_CSF1R (Macrophage colony-stimulating factor 1 receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name