CMGC_CLK3 (Dual specificity protein kinase CLK3)

Total number of chains: 29
Active chains: 16
Uniprot: CLK3_HUMAN
Kinase Domain Residues: 304 - 620
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 27 93.1% AF-P49761-K1A
DFGout None 1 3.4% 9EZ3A
None None 1 3.4% 2EXEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P49761-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 296 - 628 0 None None Dual specificity protein kinase CLK3
AF-P49761-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 296 - 628 0 None None Dual specificity protein kinase CLK3
2EU9A 1.53 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 136 - 481 0 None None Dual specificity protein kinase CLK3
6YTWA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 127 - 481 0 None None Dual specificity protein kinase CLK3
6YTWB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 134 - 481 0 None None Dual specificity protein kinase CLK3
6YU1A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KHC Type1 135 - 481 0 None None Dual specificity protein kinase CLK3
6YU1C 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KHC Type1 127 - 481 0 None None Dual specificity protein kinase CLK3
6Z51A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q8B Type1 134 - 484 0 None None Dual specificity protein kinase CLK3
6Z55A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 127 - 482 0 None None Dual specificity protein kinase CLK3
6Z55B 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 128 - 484 0 None None Dual specificity protein kinase CLK3
6FYPA 2.29 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3NG Type1 135 - 482 0 None None Dual specificity protein kinase CLK3
6FYRA 1.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAQ Type1 128 - 482 0 None None Dual specificity protein kinase CLK3
2WU6A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DKI Type1 134 - 483 0 None None Dual specificity protein kinase CLK3
2WU7A 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V25 Type1 135 - 482 0 None None Dual specificity protein kinase CLK3
3RAWA 2.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3RA Type1 134 - 484 0 None None Dual specificity protein kinase CLK3
6YTYA 1.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 127 - 481 0 None A319V Dual specificity protein kinase CLK3
6FT7A 2.02 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii E6Q Type1 129 - 484 0 None None Dual specificity protein kinase CLK3
6FT7B 2.02 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii E6Q Type1 129 - 484 0 None None Dual specificity protein kinase CLK3
6RCTA 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiii JWN Type1 135 - 484 0 None None Dual specificity protein kinase CLK3
6RCTB 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiii JWN Type1 134 - 484 0 None None Dual specificity protein kinase CLK3
6Z52A 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q8T Type1 129 - 482 0 None None Dual specificity protein kinase CLK3
6Z52B 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q8T Type1 129 - 482 0 None None Dual specificity protein kinase CLK3
6Z53A 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q7Z Type1 134 - 484 0 None None Dual specificity protein kinase CLK3
6Z54A 1.73 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q7H Type1 134 - 484 0 None None Dual specificity protein kinase CLK3
3RAWB 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 3RA Type1 136 - 484 0 None None Dual specificity protein kinase CLK3
6Z2VA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii KHC Type1 134 - 480 0 None A319V Dual specificity protein kinase CLK3
6KHFA 2.598 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi 3NG Type1 142 - 481 0 None None Dual specificity protein kinase CLK3
9EZ3A 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni A1H74 Type2 136 - 481 0 None None Dual specificity protein kinase CLK3
2EXEA 2.35 Inactive None‑None none-none in-out nonTYR APEdihe_aaiii APEdist_oiii No_ligand No_ligand 198 - 479 0 None None Dual specificity protein kinase CLK3

CMGC_CLK3 (Dual specificity protein kinase CLK3)

Total number of chains: 30
Active chains: 16
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 93.3% AF-P49761-K1A
DFGout None 1 3.3% 9EZ3A
None None 1 3.3% 2EXEA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CLK3_HUMAN AF-P49761-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 296 - 628 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN AF-P49761-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 296 - 628 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 2EU9A 1.53 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 136 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6YTWA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 127 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6YTWB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 134 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6YU1A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KHC Type1 135 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6YU1C 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii KHC Type1 127 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z51A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii Q8B Type1 134 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z55A 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 127 - 482 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z55B 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PQ5 Type1 128 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6FYPA 2.29 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3NG Type1 135 - 482 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6FYRA 1.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAQ Type1 128 - 482 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 2WU6A 1.92 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii DKI Type1 134 - 483 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 2WU7A 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii V25 Type1 135 - 482 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 3RAWA 2.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3RA Type1 134 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6YTYA 1.76 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EAE Type1 127 - 481 0 None A319V Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6FT7A 2.02 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii E6Q Type1 129 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6FT7B 2.02 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii E6Q Type1 129 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6RCTA 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiii JWN Type1 135 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6RCTB 2.32 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oiii JWN Type1 134 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z52A 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q8T Type1 129 - 482 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z52B 2.12 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q8T Type1 129 - 482 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z53A 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q7Z Type1 134 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z54A 1.73 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii Q7H Type1 134 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 3RAWB 2.09 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 3RA Type1 136 - 484 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6Z2VA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii KHC Type1 134 - 480 0 None A319V Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 6KHFA 2.598 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi 3NG Type1 142 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 9EZ3A 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni A1H74 Type2 136 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CLK3_HUMAN 2EXEA 2.35 Inactive None‑None none-none in-out nonTYR APEdihe_aaiii APEdist_oiii No_ligand No_ligand 198 - 479 0 None None Dual specificity protein kinase CLK3 Homo sapiens
W7JM86_PLAFA 8RPCA 2.079 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi A1H19 Type1 40 - 396 0 PTR228 None non-specific serine/threonine protein kinase Plasmodium falciparum UGT5.1

CMGC_CLK3 (Dual specificity protein kinase CLK3)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 8RPCA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Advanced page

Hover over column headers for tooltip help

UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
W7JM86_PLAFA 8RPCA 2.079 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi A1H19 Type1 40 - 396 0 PTR228 None non-specific serine/threonine protein kinase Plasmodium falciparum UGT5.1