CMGC_CLK3 (Dual specificity protein kinase CLK3)

Total number of chains: 29
Active chains: 16
Uniprot: CLK3_HUMAN
Kinase Domain Residues: 304 - 620
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 27 93.1% AF-P49761-K1A
DFGout None 1 3.4% 9EZ3A
None None 1 3.4% 2EXEA

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AF-P49761-K1A 296 628 490.0 No_ligand No_ligand Active DFGin 6.925 14.347 BLAminus -127.93, 174.52 62.7, 69.19 -80.33, 13.32 294.42, 92.36 -65.11, -19.27 in-in in 8.629 Saltbr-in 2.77 HRD-in -74.59, -39.16 66.57, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.98, 178.5 APE9-dihe-na 62.9, 145.52 APE8-dihe-in -62.39, 138.48 APE8-rot-in 294.2 APE67-dihe-in -68.19, -17.92 -48.98, -44.87 APE12-dist-in 13.649 APE11-dist-in 11.855 APE10-dist-in 7.432 APE9-dist-in 3.006 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[156, 472]] 1.0 AF-P49761-K1 CMGC_CLK3_HUMAN CMGC 9.2e-91 310.0 1 301 301 467 468 469 471 473 334 349 353 428 430 429 431 504 492 487 486 485 484 483 482 481 385 Dual specificity protein kinase CLK3
AF-P49761-K3A 296 628 490.0 No_ligand No_ligand Active DFGin 6.729 14.277 BLAminus -136.15, -179.71 57.63, 67.95 -79.38, 18.8 298.35, 98.24 -65.79, -18.85 in-in in 8.505 Saltbr-in 2.746 HRD-in -72.6, -38.95 67.7, -16.01 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.18, 176.81 APE9-dihe-na 60.03, 137.91 APE8-dihe-in -56.83, 140.82 APE8-rot-in 291.78 APE67-dihe-in -69.32, -19.46 -48.04, -47.21 APE12-dist-in 13.828 APE11-dist-in 11.312 APE10-dist-in 7.675 APE9-dist-in 3.096 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[156, 472]] 1.0 AF-P49761-K3 CMGC_CLK3_HUMAN CMGC 9.2e-91 310.0 1 301 301 467 468 469 471 473 334 349 353 428 430 429 431 504 492 487 486 485 484 483 482 481 385 Dual specificity protein kinase CLK3
2EU9A 136 481 490.0 No_ligand No_ligand Active DFGin 7.296 14.886 BLAminus -121.08, 177.36 60.17, 72.79 -88.53, 22.44 289.01, 93.91 -70.45, -13.88 in-in in 8.641 Saltbr-in 2.736 HRD-in -65.87, -53.21 77.46, -9.4 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.12, 168.41 APE9-dihe-na 73.94, 158.37 APE8-dihe-in -79.86, 145.17 APE8-rot-in 295.61 APE67-dihe-in -67.33, -19.94 -33.62, -58.19 APE12-dist-in 13.1 APE11-dist-in 12.079 APE10-dist-in 7.492 APE9-dist-in 3.012 None None None XRAY 1.53 0.171 0.201 A 355 345 10 0 0 0 [[156, 472]] 1.0 2eu9 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.7 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6YTWA 127 481 490.0 EAE:60512 Type1 Active DFGin 7.699 15.431 BLAminus -113.75, 171.77 74.13, 69.12 -90.55, 16.73 297.04, 88.04 -58.73, -29.5 in-in in 8.819 Saltbr-in 2.935 HRD-in -72.04, -52.05 86.8, -16.28 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.86, 165.24 APE9-dihe-na 77.16, 162.31 APE8-dihe-in -85.84, 147.02 APE8-rot-in 293.49 APE67-dihe-in -61.4, -23.59 -33.01, -61.88 APE12-dist-in 13.169 APE11-dist-in 11.948 APE10-dist-in 7.472 APE9-dist-in 2.987 None None None XRAY 2.0 0.186 0.227 A 360 347 7 0 0 0 [[156, 472]] 1.0 6ytw CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6YTWB 134 481 490.0 EAE:60512 Type1 Active DFGin 7.603 15.557 BLAminus -118.7, 170.41 71.62, 71.79 -90.05, 12.92 288.99, 100.31 -52.9, -36.56 in-in in 8.998 Saltbr-in 3.178 HRD-in -73.9, -51.74 79.51, -16.54 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.84, 174.67 APE9-dihe-na 70.75, 150.53 APE8-dihe-in -71.79, 141.9 APE8-rot-in 290.82 APE67-dihe-in -61.11, -25.78 -29.28, -64.93 APE12-dist-in 13.187 APE11-dist-in 11.77 APE10-dist-in 7.348 APE9-dist-in 2.921 None None None XRAY 2.0 0.186 0.227 B 360 339 7 0 0 0 [[156, 472]] 1.0 6ytw CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6YU1A 135 481 490.0 KHC:60510 Type1 Active DFGin 7.572 15.602 BLAminus -115.89, 173.22 73.33, 69.85 -91.55, 15.73 290.43, 91.45 -61.37, -25.51 in-in in 9.029 Saltbr-in 3.294 HRD-in -66.59, -53.53 80.71, -11.41 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.25, 166.12 APE9-dihe-na 71.09, 151.47 APE8-dihe-in -74.24, 146.96 APE8-rot-in 288.86 APE67-dihe-in -60.23, -26.89 -39.13, -58.8 APE12-dist-in 13.208 APE11-dist-in 11.355 APE10-dist-in 7.517 APE9-dist-in 2.941 None None None XRAY 1.9 0.177 0.203 a 360 340 7 0 0 0 [[156, 472]] 1.0 6yu1 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6YU1C 127 481 490.0 KHC:60519 Type1 Active DFGin 7.76 15.811 BLAminus -119.69, 170.73 79.72, 68.48 -90.33, 8.2 290.58, 93.01 -62.31, -16.94 in-in in 8.811 Saltbr-in 2.72 HRD-in -67.22, -54.95 86.99, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.81, 165.34 APE9-dihe-na 71.62, 159.9 APE8-dihe-in -82.73, 144.18 APE8-rot-in 292.06 APE67-dihe-in -70.08, -20.3 -29.27, -62.39 APE12-dist-in 13.256 APE11-dist-in 11.534 APE10-dist-in 7.599 APE9-dist-in 2.945 None None None XRAY 1.9 0.177 0.203 c 360 348 6 0 0 0 [[156, 472]] 1.0 6yu1 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z51A 134 484 490.0 Q8B:519 Type1 Active DFGin 7.644 14.723 BLAminus -120.67, -179.68 66.19, 73.26 -95.29, 10.0 295.31, 104.01 -60.15, -26.73 in-in in 8.709 Saltbr-in 3.035 HRD-in -72.92, -51.22 80.31, -10.03 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.16, 171.75 APE9-dihe-na 81.7, 153.34 APE8-dihe-in -75.14, 140.03 APE8-rot-in 295.39 APE67-dihe-in -59.48, -23.48 -45.0, -48.32 APE12-dist-in 13.964 APE11-dist-in 12.029 APE10-dist-in 7.635 APE9-dist-in 2.998 None None None XRAY 1.92 0.165 0.208 A 360 351 0 0 0 0 [[156, 472]] 1.0 6z51 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z55A 127 482 490.0 PQ5:60519 Type1 Active DFGin 7.399 15.545 BLAminus -114.58, 173.98 75.12, 75.81 -96.97, 17.81 291.53, 88.35 -70.47, -12.03 in-in in 8.893 Saltbr-in 2.643 HRD-in -73.34, -50.13 78.35, -13.23 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.62, 168.42 APE9-dihe-na 71.12, 154.19 APE8-dihe-in -74.72, 147.13 APE8-rot-in 286.47 APE67-dihe-in -63.58, -22.91 -38.61, -57.63 APE12-dist-in 13.14 APE11-dist-in 11.925 APE10-dist-in 7.448 APE9-dist-in 3.044 None None None XRAY 1.7 0.158 0.195 A 360 356 2 0 0 0 [[156, 472]] 1.0 6z55 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z55B 128 484 490.0 PQ5:60516 Type1 Active DFGin 7.357 15.526 BLAminus -113.15, 172.16 75.56, 76.57 -97.3, 14.76 289.76, 90.56 -61.38, -19.22 in-in in 8.896 Saltbr-in 2.705 HRD-in -73.58, -49.98 78.81, -11.77 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.67, 168.41 APE9-dihe-na 68.9, 153.38 APE8-dihe-in -74.53, 145.27 APE8-rot-in 288.03 APE67-dihe-in -60.23, -27.92 -39.2, -58.45 APE12-dist-in 13.128 APE11-dist-in 11.825 APE10-dist-in 7.38 APE9-dist-in 3.055 None None None XRAY 1.7 0.158 0.195 B 360 357 0 0 0 0 [[156, 472]] 1.0 6z55 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6FYPA 135 482 490.0 3NG:501 Type1 Active DFGin 7.371 14.517 BLAminus -116.73, 177.74 60.44, 79.82 -96.62, 15.47 286.13, 83.84 -75.93, 15.05 in-in in 8.93 Saltbr-in 2.503 HRD-in -67.5, -54.16 75.08, -16.75 in-in-in SNCiii in-in ActLoopNT-in 2.686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.43, 170.83 APE9-dihe-na 76.46, 148.77 APE8-dihe-in -66.24, 143.06 APE8-rot-in 302.49 APE67-dihe-in -49.68, -26.63 -51.83, -51.01 APE12-dist-in 13.97 APE11-dist-in 12.024 APE10-dist-in 7.436 APE9-dist-in 3.037 None None None XRAY 2.29 0.23 0.267 A 360 348 2 0 0 0 [[156, 472]] 1.0 6fyp CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6FYRA 128 482 490.0 EAQ:501 Type1 Active DFGin 7.297 14.954 BLAminus -115.95, 177.91 58.36, 76.24 -88.91, 20.29 289.13, 90.27 -67.91, -10.88 in-in in 8.601 Saltbr-in 2.783 HRD-in -72.14, -50.57 79.38, -13.15 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.54, 170.83 APE9-dihe-na 72.55, 158.51 APE8-dihe-in -81.87, 143.54 APE8-rot-in 293.24 APE67-dihe-in -63.5, -22.86 -31.38, -60.72 APE12-dist-in 12.975 APE11-dist-in 12.046 APE10-dist-in 7.438 APE9-dist-in 2.973 None None None XRAY 1.42 0.177 0.189 A 360 355 2 0 0 0 [[156, 472]] 1.0 6fyr CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
2WU6A 134 483 490.0 DKI:1484 Type1 Active DFGin 7.776 14.965 BLAminus -116.93, 179.15 62.45, 72.51 -89.63, 16.68 295.06, 87.4 -62.0, -34.07 in-in in 8.813 Saltbr-in 2.801 HRD-in -68.44, -54.58 75.53, -12.92 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.93, 172.91 APE9-dihe-na 77.89, 155.84 APE8-dihe-in -77.47, 138.03 APE8-rot-in 290.67 APE67-dihe-in -61.22, -21.77 -44.41, -49.37 APE12-dist-in 13.725 APE11-dist-in 11.724 APE10-dist-in 7.334 APE9-dist-in 3.007 None None None XRAY 1.92 0.172 0.211 A 381 350 1 0 0 0 [[156, 472]] 1.0 2wu6 CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
2WU7A 135 482 490.0 V25:1483 Type1 Active DFGin 7.241 14.714 BLAminus -114.75, 172.06 62.02, 79.06 -94.21, 16.42 291.52, 93.21 -58.97, -25.24 in-in in 8.664 Saltbr-in 2.623 HRD-in -60.15, -57.82 78.68, -17.46 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, 172.35 APE9-dihe-na 73.64, 152.38 APE8-dihe-in -73.02, 138.27 APE8-rot-in 276.31 APE67-dihe-in -55.71, -20.76 -37.92, -58.02 APE12-dist-in 13.825 APE11-dist-in 11.773 APE10-dist-in 7.437 APE9-dist-in 2.965 None None None XRAY 2.25 0.193 0.246 A 381 348 2 0 0 0 [[156, 472]] 1.0 2wu7 CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
3RAWA 134 484 490.0 3RA:1 Type1 Active DFGin 6.902 14.094 BLAminus -124.35, 169.55 70.36, 85.35 -106.01, 17.22 295.02, 93.37 -60.15, -19.42 in-in in 8.723 Saltbr-in 2.53 HRD-in -75.41, -55.66 80.86, -13.12 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.35, 172.08 APE9-dihe-na 79.18, 152.43 APE8-dihe-in -65.73, 139.23 APE8-rot-in 296.11 APE67-dihe-in -63.4, -21.96 -51.62, -42.74 APE12-dist-in 13.898 APE11-dist-in 11.94 APE10-dist-in 7.402 APE9-dist-in 3.059 None None None XRAY 2.09 0.182 0.219 A 381 351 0 0 0 0 [[156, 472]] 1.0 3raw CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6YTYA 127 481 490.0 EAE:502 Type1 Active DFGin 7.292 14.727 BLAminus -118.42, -179.04 54.61, 81.07 -90.19, 20.66 288.13, 83.57 -71.98, -12.75 in-in in 8.863 Saltbr-in 2.708 HRD-in -69.86, -53.68 84.67, -14.39 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.82, 173.51 APE9-dihe-na 70.8, 155.7 APE8-dihe-in -74.76, 144.22 APE8-rot-in 294.49 APE67-dihe-in -64.1, -22.37 -34.78, -62.17 APE12-dist-in 13.01 APE11-dist-in 12.048 APE10-dist-in 7.398 APE9-dist-in 2.965 A319V None None XRAY 1.76 0.188 0.224 A 360 353 5 0 0 0 [[156, 472]] 1.0 6yty CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6FT7A 129 484 490.0 E6Q:511 Type1 Inactive DFGin 7.321 14.781 BLAminus -120.9, 175.35 64.57, 74.33 -90.97, 23.71 286.5, 96.81 -69.99, -9.79 in-in in 8.887 Saltbr-in 2.823 HRD-in -70.16, -48.94 78.21, -14.43 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -131.5, 167.46 APE9-dihe-na 82.88, 152.07 APE8-dihe-in -68.62, 139.4 APE8-rot-in 290.93 APE67-dihe-in -65.99, -21.91 -50.69, -45.65 APE12-dist-out 14.597 APE11-dist-in 12.213 APE10-dist-in 7.754 APE9-dist-in 3.012 None None None XRAY 2.02 0.194 0.235 A 360 356 0 0 0 0 [[156, 472]] 1.0 6ft7 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6FT7B 129 484 490.0 E6Q:517 Type1 Inactive DFGin 7.188 14.572 BLAminus -124.99, 174.23 56.23, 77.99 -90.35, 20.52 293.64, 89.59 -66.25, -13.82 in-in in 8.887 Saltbr-in 2.77 HRD-in -77.25, -46.27 73.14, -13.19 in-in-out SNCiio in-out ActLoopNT-in 2.834 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -135.25, 172.02 APE9-dihe-na 83.65, 151.41 APE8-dihe-in -69.26, 142.25 APE8-rot-in 295.99 APE67-dihe-in -63.0, -17.39 -50.49, -47.23 APE12-dist-out 14.362 APE11-dist-in 12.245 APE10-dist-in 7.631 APE9-dist-in 3.176 None None None XRAY 2.02 0.194 0.235 B 360 356 0 0 0 0 [[156, 472]] 1.0 6ft7 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6RCTA 135 484 490.0 JWN:501 Type1 Inactive DFGin 6.985 14.352 BLAminus -131.29, 167.51 65.16, 94.18 -109.68, 25.72 290.89, 89.89 -69.08, -14.81 in-in in 8.509 Saltbr-in 2.909 HRD-in -66.73, -49.18 73.82, -22.5 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -136.57, 171.42 APE9-dihe-na 73.43, 150.27 APE8-dihe-in -78.92, 148.82 APE8-rot-out 67.63 APE67-dihe-in -63.73, -23.17 -49.79, -45.3 APE12-dist-out 14.211 APE11-dist-in 12.08 APE10-dist-in 7.428 APE9-dist-in 3.16 None None None XRAY 2.32 0.208 0.243 A 360 350 0 0 0 0 [[156, 472]] 1.0 6rct CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6RCTB 134 484 490.0 JWN:501 Type1 Inactive DFGin 7.011 14.401 BLAminus -132.74, 167.4 64.39, 94.57 -109.17, 25.8 290.92, 88.58 -67.13, -15.81 in-in in 8.536 Saltbr-in 2.887 HRD-in -66.68, -49.2 71.66, -20.14 in-in-out SNCiio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -134.47, 171.62 APE9-dihe-na 74.04, 150.43 APE8-dihe-in -78.69, 150.56 APE8-rot-out 66.52 APE67-dihe-in -66.58, -21.34 -47.66, -47.6 APE12-dist-out 14.229 APE11-dist-in 12.062 APE10-dist-in 7.457 APE9-dist-in 3.167 None None None XRAY 2.32 0.208 0.243 B 360 351 0 0 0 0 [[156, 472]] 1.0 6rct CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z52A 129 482 490.0 Q8T:515 Type1 Inactive DFGin 7.291 14.491 BLAminus -120.26, -173.43 41.29, 118.63 -126.38, 35.13 288.12, 99.24 -73.85, -10.21 in-in in 8.939 Saltbr-in 2.792 HRD-in -68.77, -51.81 78.51, -10.02 in-in-out SNCiio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -132.31, 178.79 APE9-dihe-na 74.92, 150.63 APE8-dihe-in -72.0, 141.8 APE8-rot-in 294.88 APE67-dihe-in -66.55, -21.27 -43.96, -48.09 APE12-dist-out 14.604 APE11-dist-in 12.427 APE10-dist-in 7.687 APE9-dist-in 3.017 None None None XRAY 2.12 0.181 0.23 A 360 354 2 0 0 0 [[156, 472]] 1.0 6z52 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z52B 129 482 490.0 Q8T:515 Type1 Inactive DFGin 7.327 14.379 BLAminus -114.9, -175.17 44.37, 120.46 -126.62, 30.55 291.75, 97.1 -71.13, -13.43 in-in in 9.071 Saltbr-in 2.77 HRD-in -72.55, -50.75 76.72, -12.89 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -132.87, 173.69 APE9-dihe-na 74.46, 155.93 APE8-dihe-in -78.81, 140.06 APE8-rot-in 287.01 APE67-dihe-in -59.68, -28.7 -45.16, -46.66 APE12-dist-out 14.472 APE11-dist-in 12.256 APE10-dist-in 7.819 APE9-dist-in 3.058 None None None XRAY 2.12 0.181 0.23 B 360 354 2 0 0 0 [[156, 472]] 1.0 6z52 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z53A 134 484 490.0 Q7Z:517 Type1 Inactive DFGin 7.782 14.733 BLAminus -125.59, -177.74 64.66, 75.64 -98.0, 9.54 294.43, 103.78 -65.33, -19.46 in-in in 8.768 Saltbr-in 2.942 HRD-in -72.19, -49.25 80.06, -15.14 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -135.12, 172.14 APE9-dihe-na 75.26, 155.54 APE8-dihe-in -74.14, 140.42 APE8-rot-in 294.82 APE67-dihe-in -59.75, -21.48 -47.85, -51.12 APE12-dist-out 14.034 APE11-dist-in 12.113 APE10-dist-in 7.661 APE9-dist-in 2.977 None None None XRAY 1.65 0.169 0.195 A 360 351 0 0 0 0 [[156, 472]] 1.0 6z53 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z54A 134 484 490.0 Q7H:515 Type1 Inactive DFGin 7.674 14.595 BLAminus -125.05, 179.02 68.73, 75.24 -98.01, 11.32 293.45, 103.47 -61.42, -28.22 in-in in 8.665 Saltbr-in 3.051 HRD-in -71.39, -49.66 79.09, -14.79 in-in-out SNCiio in-out ActLoopNT-in 2.85 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -133.84, 171.28 APE9-dihe-na 77.41, 152.33 APE8-dihe-in -71.61, 140.97 APE8-rot-in 294.45 APE67-dihe-in -59.89, -22.0 -51.0, -49.44 APE12-dist-out 14.026 APE11-dist-in 12.115 APE10-dist-in 7.607 APE9-dist-in 2.951 None None None XRAY 1.73 0.163 0.196 A 360 351 0 0 0 0 [[156, 472]] 1.0 6z54 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
3RAWB 136 484 490.0 3RA:2 Type1 Inactive DFGin 6.965 14.237 BLAminus -117.05, 172.91 67.87, 90.75 -108.68, 15.88 294.71, 94.5 -64.13, -12.21 in-in in 8.834 Saltbr-in 2.616 HRD-in -69.6, -50.25 74.29, -8.39 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -132.65, 172.79 APE9-dihe-na 79.02, 155.93 APE8-dihe-in -74.0, 140.2 APE8-rot-in 285.33 APE67-dihe-in -62.33, -24.2 -48.19, -48.04 APE12-dist-out 14.116 APE11-dist-in 11.909 APE10-dist-in 7.488 APE9-dist-in 3.002 None None None XRAY 2.09 0.182 0.219 B 381 349 0 0 0 0 [[156, 472]] 1.0 3raw CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6Z2VA 134 480 490.0 KHC:501 Type1 Inactive DFGin 7.354 14.838 BLAminus -146.99, 161.86 65.01, 78.44 -89.71, 17.58 291.55, 82.78 -63.88, -18.76 in-in in 8.43 Saltbr-in 3.12 HRD-in -84.04, -51.62 87.06, -5.78 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.4, 157.64 APE9-dihe-na 69.72, 152.96 APE8-dihe-in -83.82, 151.16 APE8-rot-out 81.04 APE67-dihe-in -60.61, -31.57 -38.95, -59.12 APE12-dist-in 13.062 APE11-dist-in 12.039 APE10-dist-in 7.865 APE9-dist-in 2.853 A319V None None XRAY 2.6 0.205 0.265 A 360 339 8 0 0 0 [[156, 472]] 1.0 6z2v CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
6KHFA 142 481 490.0 3NG:1000 Type1 Inactive DFGin 7.15 14.219 BLAminus -127.11, -179.47 56.9, 68.81 -87.1, 27.16 289.67, 76.33 -67.97, -3.15 in-in in 8.845 Saltbr-in 2.725 HRD-out -71.79, 130.53 -107.28, 17.73 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -140.37, -24.13 APE9-dihe-na -98.19, 177.1 APE8-dihe-in -67.74, 125.23 APE8-rot-in 310.54 APE67-dihe-in -68.95, -22.53 -32.12, -48.44 APE12-dist-out 14.308 APE11-dist-in 12.383 APE10-dist-out 8.09 APE9-dist-in 3.641 None None None XRAY 2.598 0.229 0.284 A 490 327 15 0 0 0 [[156, 472]] 1.0 6khf CMGC_CLK3_HUMAN CMGC 3.4e-90 308.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
9EZ3A 136 481 490.0 A1H74:502 Type2 Inactive DFGout 16.998 8.291 None -128.15, 178.46 -155.63, 110.75 -66.24, -31.17 198.15, 50.73 79.35, 999.0 in-in in 8.174 Saltbr-in 3.041 HRD-in -67.98, -56.04 75.99, -25.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.34, 163.79 APE9-dihe-na 74.59, 163.12 APE8-dihe-in -93.15, 147.67 APE8-rot-in 295.87 APE67-dihe-in -65.84, -11.54 -36.31, -63.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.156 None None None XRAY 2.7 0.206 0.268 A 360 335 14 0 0 11 [[156, 472]] 1.0 9ez3 CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
2EXEA 198 479 490.0 No_ligand No_ligand Inactive None 7.649 999.0 None -120.7, 177.41 63.29, 75.6 -91.62, 15.52 299.12, 87.11 -54.14, -25.86 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.06, -50.66 79.06, -17.2 none-in-out SNCnio in-out ActLoopNT-in 2.78 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -135.42, 173.5 APE9-dihe-na 72.68, 152.2 APE8-dihe-in -73.33, 142.23 APE8-rot-in 283.13 APE67-dihe-in -59.06, -21.19 -44.66, -54.89 APE12-dist-out 14.146 APE11-dist-in 12.338 APE10-dist-in 7.66 APE9-dist-in 2.981 None None None XRAY 2.35 0.227 0.26 A 357 262 7 0 0 0 [[156, 472]] 1.0 2exe CMGC_CLK3_HUMAN CMGC 1.2e-90 309.7 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3

CMGC_CLK3 (Dual specificity protein kinase CLK3)

Total number of chains: 30
Active chains: 16
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 93.3% AF-P49761-K1A
DFGout None 1 3.3% 9EZ3A
None None 1 3.3% 2EXEA

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CLK3_HUMAN AF-P49761-K1A P49761 296 628 490.0 No_ligand No_ligand Active DFGin 6.925 14.347 BLAminus -127.93, 174.52 62.7, 69.19 -80.33, 13.32 294.42, 92.36 -65.11, -19.27 in-in in 8.629 Saltbr-in 2.77 HRD-in -74.59, -39.16 66.57, -2.5 in-in-in SNCiii in-in ActLoopNT-in 2.925 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.98, 178.5 APE9-dihe-na 62.9, 145.52 APE8-dihe-in -62.39, 138.48 APE8-rot-in 294.2 APE67-dihe-in -68.19, -17.92 -48.98, -44.87 APE12-dist-in 13.649 APE11-dist-in 11.855 APE10-dist-in 7.432 APE9-dist-in 3.006 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[156, 472]] 1.0 AF-P49761-K1 Homo sapiens CMGC_CLK3_HUMAN CMGC 9.2e-91 310.0 1 301 301 467 468 469 471 473 334 349 353 428 430 429 431 504 492 487 486 485 484 483 482 481 385 Dual specificity protein kinase CLK3
CLK3_HUMAN AF-P49761-K3A P49761 296 628 490.0 No_ligand No_ligand Active DFGin 6.729 14.277 BLAminus -136.15, -179.71 57.63, 67.95 -79.38, 18.8 298.35, 98.24 -65.79, -18.85 in-in in 8.505 Saltbr-in 2.746 HRD-in -72.6, -38.95 67.7, -16.01 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.18, 176.81 APE9-dihe-na 60.03, 137.91 APE8-dihe-in -56.83, 140.82 APE8-rot-in 291.78 APE67-dihe-in -69.32, -19.46 -48.04, -47.21 APE12-dist-in 13.828 APE11-dist-in 11.312 APE10-dist-in 7.675 APE9-dist-in 3.096 None None None AF2 -1.0 1.0 1.0 A 333 333 0 0 0 0 [[156, 472]] 1.0 AF-P49761-K3 Homo sapiens CMGC_CLK3_HUMAN CMGC 9.2e-91 310.0 1 301 301 467 468 469 471 473 334 349 353 428 430 429 431 504 492 487 486 485 484 483 482 481 385 Dual specificity protein kinase CLK3
CLK3_HUMAN 2EU9A P49761 136 481 490.0 No_ligand No_ligand Active DFGin 7.296 14.886 BLAminus -121.08, 177.36 60.17, 72.79 -88.53, 22.44 289.01, 93.91 -70.45, -13.88 in-in in 8.641 Saltbr-in 2.736 HRD-in -65.87, -53.21 77.46, -9.4 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.12, 168.41 APE9-dihe-na 73.94, 158.37 APE8-dihe-in -79.86, 145.17 APE8-rot-in 295.61 APE67-dihe-in -67.33, -19.94 -33.62, -58.19 APE12-dist-in 13.1 APE11-dist-in 12.079 APE10-dist-in 7.492 APE9-dist-in 3.012 None None None XRAY 1.53 0.171 0.201 A 355 345 10 0 0 0 [[156, 472]] 1.0 2eu9 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.7 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6YTWA P49761 127 481 490.0 EAE:60512 Type1 Active DFGin 7.699 15.431 BLAminus -113.75, 171.77 74.13, 69.12 -90.55, 16.73 297.04, 88.04 -58.73, -29.5 in-in in 8.819 Saltbr-in 2.935 HRD-in -72.04, -52.05 86.8, -16.28 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.86, 165.24 APE9-dihe-na 77.16, 162.31 APE8-dihe-in -85.84, 147.02 APE8-rot-in 293.49 APE67-dihe-in -61.4, -23.59 -33.01, -61.88 APE12-dist-in 13.169 APE11-dist-in 11.948 APE10-dist-in 7.472 APE9-dist-in 2.987 None None None XRAY 2.0 0.186 0.227 A 360 347 7 0 0 0 [[156, 472]] 1.0 6ytw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6YTWB P49761 134 481 490.0 EAE:60512 Type1 Active DFGin 7.603 15.557 BLAminus -118.7, 170.41 71.62, 71.79 -90.05, 12.92 288.99, 100.31 -52.9, -36.56 in-in in 8.998 Saltbr-in 3.178 HRD-in -73.9, -51.74 79.51, -16.54 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.84, 174.67 APE9-dihe-na 70.75, 150.53 APE8-dihe-in -71.79, 141.9 APE8-rot-in 290.82 APE67-dihe-in -61.11, -25.78 -29.28, -64.93 APE12-dist-in 13.187 APE11-dist-in 11.77 APE10-dist-in 7.348 APE9-dist-in 2.921 None None None XRAY 2.0 0.186 0.227 B 360 339 7 0 0 0 [[156, 472]] 1.0 6ytw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6YU1A P49761 135 481 490.0 KHC:60510 Type1 Active DFGin 7.572 15.602 BLAminus -115.89, 173.22 73.33, 69.85 -91.55, 15.73 290.43, 91.45 -61.37, -25.51 in-in in 9.029 Saltbr-in 3.294 HRD-in -66.59, -53.53 80.71, -11.41 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.25, 166.12 APE9-dihe-na 71.09, 151.47 APE8-dihe-in -74.24, 146.96 APE8-rot-in 288.86 APE67-dihe-in -60.23, -26.89 -39.13, -58.8 APE12-dist-in 13.208 APE11-dist-in 11.355 APE10-dist-in 7.517 APE9-dist-in 2.941 None None None XRAY 1.9 0.177 0.203 a 360 340 7 0 0 0 [[156, 472]] 1.0 6yu1 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6YU1C P49761 127 481 490.0 KHC:60519 Type1 Active DFGin 7.76 15.811 BLAminus -119.69, 170.73 79.72, 68.48 -90.33, 8.2 290.58, 93.01 -62.31, -16.94 in-in in 8.811 Saltbr-in 2.72 HRD-in -67.22, -54.95 86.99, -15.49 in-in-in SNCiii in-in ActLoopNT-in 2.831 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.81, 165.34 APE9-dihe-na 71.62, 159.9 APE8-dihe-in -82.73, 144.18 APE8-rot-in 292.06 APE67-dihe-in -70.08, -20.3 -29.27, -62.39 APE12-dist-in 13.256 APE11-dist-in 11.534 APE10-dist-in 7.599 APE9-dist-in 2.945 None None None XRAY 1.9 0.177 0.203 c 360 348 6 0 0 0 [[156, 472]] 1.0 6yu1 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z51A P49761 134 484 490.0 Q8B:519 Type1 Active DFGin 7.644 14.723 BLAminus -120.67, -179.68 66.19, 73.26 -95.29, 10.0 295.31, 104.01 -60.15, -26.73 in-in in 8.709 Saltbr-in 3.035 HRD-in -72.92, -51.22 80.31, -10.03 in-in-in SNCiii in-in ActLoopNT-in 2.804 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.16, 171.75 APE9-dihe-na 81.7, 153.34 APE8-dihe-in -75.14, 140.03 APE8-rot-in 295.39 APE67-dihe-in -59.48, -23.48 -45.0, -48.32 APE12-dist-in 13.964 APE11-dist-in 12.029 APE10-dist-in 7.635 APE9-dist-in 2.998 None None None XRAY 1.92 0.165 0.208 A 360 351 0 0 0 0 [[156, 472]] 1.0 6z51 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z55A P49761 127 482 490.0 PQ5:60519 Type1 Active DFGin 7.399 15.545 BLAminus -114.58, 173.98 75.12, 75.81 -96.97, 17.81 291.53, 88.35 -70.47, -12.03 in-in in 8.893 Saltbr-in 2.643 HRD-in -73.34, -50.13 78.35, -13.23 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.62, 168.42 APE9-dihe-na 71.12, 154.19 APE8-dihe-in -74.72, 147.13 APE8-rot-in 286.47 APE67-dihe-in -63.58, -22.91 -38.61, -57.63 APE12-dist-in 13.14 APE11-dist-in 11.925 APE10-dist-in 7.448 APE9-dist-in 3.044 None None None XRAY 1.7 0.158 0.195 A 360 356 2 0 0 0 [[156, 472]] 1.0 6z55 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z55B P49761 128 484 490.0 PQ5:60516 Type1 Active DFGin 7.357 15.526 BLAminus -113.15, 172.16 75.56, 76.57 -97.3, 14.76 289.76, 90.56 -61.38, -19.22 in-in in 8.896 Saltbr-in 2.705 HRD-in -73.58, -49.98 78.81, -11.77 in-in-in SNCiii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.67, 168.41 APE9-dihe-na 68.9, 153.38 APE8-dihe-in -74.53, 145.27 APE8-rot-in 288.03 APE67-dihe-in -60.23, -27.92 -39.2, -58.45 APE12-dist-in 13.128 APE11-dist-in 11.825 APE10-dist-in 7.38 APE9-dist-in 3.055 None None None XRAY 1.7 0.158 0.195 B 360 357 0 0 0 0 [[156, 472]] 1.0 6z55 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6FYPA P49761 135 482 490.0 3NG:501 Type1 Active DFGin 7.371 14.517 BLAminus -116.73, 177.74 60.44, 79.82 -96.62, 15.47 286.13, 83.84 -75.93, 15.05 in-in in 8.93 Saltbr-in 2.503 HRD-in -67.5, -54.16 75.08, -16.75 in-in-in SNCiii in-in ActLoopNT-in 2.686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.43, 170.83 APE9-dihe-na 76.46, 148.77 APE8-dihe-in -66.24, 143.06 APE8-rot-in 302.49 APE67-dihe-in -49.68, -26.63 -51.83, -51.01 APE12-dist-in 13.97 APE11-dist-in 12.024 APE10-dist-in 7.436 APE9-dist-in 3.037 None None None XRAY 2.29 0.23 0.267 A 360 348 2 0 0 0 [[156, 472]] 1.0 6fyp Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6FYRA P49761 128 482 490.0 EAQ:501 Type1 Active DFGin 7.297 14.954 BLAminus -115.95, 177.91 58.36, 76.24 -88.91, 20.29 289.13, 90.27 -67.91, -10.88 in-in in 8.601 Saltbr-in 2.783 HRD-in -72.14, -50.57 79.38, -13.15 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.54, 170.83 APE9-dihe-na 72.55, 158.51 APE8-dihe-in -81.87, 143.54 APE8-rot-in 293.24 APE67-dihe-in -63.5, -22.86 -31.38, -60.72 APE12-dist-in 12.975 APE11-dist-in 12.046 APE10-dist-in 7.438 APE9-dist-in 2.973 None None None XRAY 1.42 0.177 0.189 A 360 355 2 0 0 0 [[156, 472]] 1.0 6fyr Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 2WU6A P49761 134 483 490.0 DKI:1484 Type1 Active DFGin 7.776 14.965 BLAminus -116.93, 179.15 62.45, 72.51 -89.63, 16.68 295.06, 87.4 -62.0, -34.07 in-in in 8.813 Saltbr-in 2.801 HRD-in -68.44, -54.58 75.53, -12.92 in-in-in SNCiii in-in ActLoopNT-in 2.825 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.93, 172.91 APE9-dihe-na 77.89, 155.84 APE8-dihe-in -77.47, 138.03 APE8-rot-in 290.67 APE67-dihe-in -61.22, -21.77 -44.41, -49.37 APE12-dist-in 13.725 APE11-dist-in 11.724 APE10-dist-in 7.334 APE9-dist-in 3.007 None None None XRAY 1.92 0.172 0.211 A 381 350 1 0 0 0 [[156, 472]] 1.0 2wu6 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 2WU7A P49761 135 482 490.0 V25:1483 Type1 Active DFGin 7.241 14.714 BLAminus -114.75, 172.06 62.02, 79.06 -94.21, 16.42 291.52, 93.21 -58.97, -25.24 in-in in 8.664 Saltbr-in 2.623 HRD-in -60.15, -57.82 78.68, -17.46 in-in-in SNCiii in-in ActLoopNT-in 2.814 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.77, 172.35 APE9-dihe-na 73.64, 152.38 APE8-dihe-in -73.02, 138.27 APE8-rot-in 276.31 APE67-dihe-in -55.71, -20.76 -37.92, -58.02 APE12-dist-in 13.825 APE11-dist-in 11.773 APE10-dist-in 7.437 APE9-dist-in 2.965 None None None XRAY 2.25 0.193 0.246 A 381 348 2 0 0 0 [[156, 472]] 1.0 2wu7 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 3RAWA P49761 134 484 490.0 3RA:1 Type1 Active DFGin 6.902 14.094 BLAminus -124.35, 169.55 70.36, 85.35 -106.01, 17.22 295.02, 93.37 -60.15, -19.42 in-in in 8.723 Saltbr-in 2.53 HRD-in -75.41, -55.66 80.86, -13.12 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.35, 172.08 APE9-dihe-na 79.18, 152.43 APE8-dihe-in -65.73, 139.23 APE8-rot-in 296.11 APE67-dihe-in -63.4, -21.96 -51.62, -42.74 APE12-dist-in 13.898 APE11-dist-in 11.94 APE10-dist-in 7.402 APE9-dist-in 3.059 None None None XRAY 2.09 0.182 0.219 A 381 351 0 0 0 0 [[156, 472]] 1.0 3raw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6YTYA P49761 127 481 490.0 EAE:502 Type1 Active DFGin 7.292 14.727 BLAminus -118.42, -179.04 54.61, 81.07 -90.19, 20.66 288.13, 83.57 -71.98, -12.75 in-in in 8.863 Saltbr-in 2.708 HRD-in -69.86, -53.68 84.67, -14.39 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.82, 173.51 APE9-dihe-na 70.8, 155.7 APE8-dihe-in -74.76, 144.22 APE8-rot-in 294.49 APE67-dihe-in -64.1, -22.37 -34.78, -62.17 APE12-dist-in 13.01 APE11-dist-in 12.048 APE10-dist-in 7.398 APE9-dist-in 2.965 A319V None None XRAY 1.76 0.188 0.224 A 360 353 5 0 0 0 [[156, 472]] 1.0 6yty Homo sapiens CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6FT7A P49761 129 484 490.0 E6Q:511 Type1 Inactive DFGin 7.321 14.781 BLAminus -120.9, 175.35 64.57, 74.33 -90.97, 23.71 286.5, 96.81 -69.99, -9.79 in-in in 8.887 Saltbr-in 2.823 HRD-in -70.16, -48.94 78.21, -14.43 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -131.5, 167.46 APE9-dihe-na 82.88, 152.07 APE8-dihe-in -68.62, 139.4 APE8-rot-in 290.93 APE67-dihe-in -65.99, -21.91 -50.69, -45.65 APE12-dist-out 14.597 APE11-dist-in 12.213 APE10-dist-in 7.754 APE9-dist-in 3.012 None None None XRAY 2.02 0.194 0.235 A 360 356 0 0 0 0 [[156, 472]] 1.0 6ft7 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6FT7B P49761 129 484 490.0 E6Q:517 Type1 Inactive DFGin 7.188 14.572 BLAminus -124.99, 174.23 56.23, 77.99 -90.35, 20.52 293.64, 89.59 -66.25, -13.82 in-in in 8.887 Saltbr-in 2.77 HRD-in -77.25, -46.27 73.14, -13.19 in-in-out SNCiio in-out ActLoopNT-in 2.834 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -135.25, 172.02 APE9-dihe-na 83.65, 151.41 APE8-dihe-in -69.26, 142.25 APE8-rot-in 295.99 APE67-dihe-in -63.0, -17.39 -50.49, -47.23 APE12-dist-out 14.362 APE11-dist-in 12.245 APE10-dist-in 7.631 APE9-dist-in 3.176 None None None XRAY 2.02 0.194 0.235 B 360 356 0 0 0 0 [[156, 472]] 1.0 6ft7 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6RCTA P49761 135 484 490.0 JWN:501 Type1 Inactive DFGin 6.985 14.352 BLAminus -131.29, 167.51 65.16, 94.18 -109.68, 25.72 290.89, 89.89 -69.08, -14.81 in-in in 8.509 Saltbr-in 2.909 HRD-in -66.73, -49.18 73.82, -22.5 in-in-out SNCiio in-out ActLoopNT-in 2.835 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -136.57, 171.42 APE9-dihe-na 73.43, 150.27 APE8-dihe-in -78.92, 148.82 APE8-rot-out 67.63 APE67-dihe-in -63.73, -23.17 -49.79, -45.3 APE12-dist-out 14.211 APE11-dist-in 12.08 APE10-dist-in 7.428 APE9-dist-in 3.16 None None None XRAY 2.32 0.208 0.243 A 360 350 0 0 0 0 [[156, 472]] 1.0 6rct Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6RCTB P49761 134 484 490.0 JWN:501 Type1 Inactive DFGin 7.011 14.401 BLAminus -132.74, 167.4 64.39, 94.57 -109.17, 25.8 290.92, 88.58 -67.13, -15.81 in-in in 8.536 Saltbr-in 2.887 HRD-in -66.68, -49.2 71.66, -20.14 in-in-out SNCiio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiii APE10-dihe-na -134.47, 171.62 APE9-dihe-na 74.04, 150.43 APE8-dihe-in -78.69, 150.56 APE8-rot-out 66.52 APE67-dihe-in -66.58, -21.34 -47.66, -47.6 APE12-dist-out 14.229 APE11-dist-in 12.062 APE10-dist-in 7.457 APE9-dist-in 3.167 None None None XRAY 2.32 0.208 0.243 B 360 351 0 0 0 0 [[156, 472]] 1.0 6rct Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z52A P49761 129 482 490.0 Q8T:515 Type1 Inactive DFGin 7.291 14.491 BLAminus -120.26, -173.43 41.29, 118.63 -126.38, 35.13 288.12, 99.24 -73.85, -10.21 in-in in 8.939 Saltbr-in 2.792 HRD-in -68.77, -51.81 78.51, -10.02 in-in-out SNCiio in-out ActLoopNT-in 2.822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -132.31, 178.79 APE9-dihe-na 74.92, 150.63 APE8-dihe-in -72.0, 141.8 APE8-rot-in 294.88 APE67-dihe-in -66.55, -21.27 -43.96, -48.09 APE12-dist-out 14.604 APE11-dist-in 12.427 APE10-dist-in 7.687 APE9-dist-in 3.017 None None None XRAY 2.12 0.181 0.23 A 360 354 2 0 0 0 [[156, 472]] 1.0 6z52 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z52B P49761 129 482 490.0 Q8T:515 Type1 Inactive DFGin 7.327 14.379 BLAminus -114.9, -175.17 44.37, 120.46 -126.62, 30.55 291.75, 97.1 -71.13, -13.43 in-in in 9.071 Saltbr-in 2.77 HRD-in -72.55, -50.75 76.72, -12.89 in-in-out SNCiio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -132.87, 173.69 APE9-dihe-na 74.46, 155.93 APE8-dihe-in -78.81, 140.06 APE8-rot-in 287.01 APE67-dihe-in -59.68, -28.7 -45.16, -46.66 APE12-dist-out 14.472 APE11-dist-in 12.256 APE10-dist-in 7.819 APE9-dist-in 3.058 None None None XRAY 2.12 0.181 0.23 B 360 354 2 0 0 0 [[156, 472]] 1.0 6z52 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z53A P49761 134 484 490.0 Q7Z:517 Type1 Inactive DFGin 7.782 14.733 BLAminus -125.59, -177.74 64.66, 75.64 -98.0, 9.54 294.43, 103.78 -65.33, -19.46 in-in in 8.768 Saltbr-in 2.942 HRD-in -72.19, -49.25 80.06, -15.14 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -135.12, 172.14 APE9-dihe-na 75.26, 155.54 APE8-dihe-in -74.14, 140.42 APE8-rot-in 294.82 APE67-dihe-in -59.75, -21.48 -47.85, -51.12 APE12-dist-out 14.034 APE11-dist-in 12.113 APE10-dist-in 7.661 APE9-dist-in 2.977 None None None XRAY 1.65 0.169 0.195 A 360 351 0 0 0 0 [[156, 472]] 1.0 6z53 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z54A P49761 134 484 490.0 Q7H:515 Type1 Inactive DFGin 7.674 14.595 BLAminus -125.05, 179.02 68.73, 75.24 -98.01, 11.32 293.45, 103.47 -61.42, -28.22 in-in in 8.665 Saltbr-in 3.051 HRD-in -71.39, -49.66 79.09, -14.79 in-in-out SNCiio in-out ActLoopNT-in 2.85 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -133.84, 171.28 APE9-dihe-na 77.41, 152.33 APE8-dihe-in -71.61, 140.97 APE8-rot-in 294.45 APE67-dihe-in -59.89, -22.0 -51.0, -49.44 APE12-dist-out 14.026 APE11-dist-in 12.115 APE10-dist-in 7.607 APE9-dist-in 2.951 None None None XRAY 1.73 0.163 0.196 A 360 351 0 0 0 0 [[156, 472]] 1.0 6z54 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 3RAWB P49761 136 484 490.0 3RA:2 Type1 Inactive DFGin 6.965 14.237 BLAminus -117.05, 172.91 67.87, 90.75 -108.68, 15.88 294.71, 94.5 -64.13, -12.21 in-in in 8.834 Saltbr-in 2.616 HRD-in -69.6, -50.25 74.29, -8.39 in-in-out SNCiio in-out ActLoopNT-in 2.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -132.65, 172.79 APE9-dihe-na 79.02, 155.93 APE8-dihe-in -74.0, 140.2 APE8-rot-in 285.33 APE67-dihe-in -62.33, -24.2 -48.19, -48.04 APE12-dist-out 14.116 APE11-dist-in 11.909 APE10-dist-in 7.488 APE9-dist-in 3.002 None None None XRAY 2.09 0.182 0.219 B 381 349 0 0 0 0 [[156, 472]] 1.0 3raw Homo sapiens CMGC_CLK3_HUMAN CMGC 1.5e-90 309.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6Z2VA P49761 134 480 490.0 KHC:501 Type1 Inactive DFGin 7.354 14.838 BLAminus -146.99, 161.86 65.01, 78.44 -89.71, 17.58 291.55, 82.78 -63.88, -18.76 in-in in 8.43 Saltbr-in 3.12 HRD-in -84.04, -51.62 87.06, -5.78 in-in-out SNCiio in-out ActLoopNT-in 3.03 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.4, 157.64 APE9-dihe-na 69.72, 152.96 APE8-dihe-in -83.82, 151.16 APE8-rot-out 81.04 APE67-dihe-in -60.61, -31.57 -38.95, -59.12 APE12-dist-in 13.062 APE11-dist-in 12.039 APE10-dist-in 7.865 APE9-dist-in 2.853 A319V None None XRAY 2.6 0.205 0.265 A 360 339 8 0 0 0 [[156, 472]] 1.0 6z2v Homo sapiens CMGC_CLK3_HUMAN CMGC 2e-90 308.9 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 6KHFA P49761 142 481 490.0 3NG:1000 Type1 Inactive DFGin 7.15 14.219 BLAminus -127.11, -179.47 56.9, 68.81 -87.1, 27.16 289.67, 76.33 -67.97, -3.15 in-in in 8.845 Saltbr-in 2.725 HRD-out -71.79, 130.53 -107.28, 17.73 in-in-out SNCiio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -140.37, -24.13 APE9-dihe-na -98.19, 177.1 APE8-dihe-in -67.74, 125.23 APE8-rot-in 310.54 APE67-dihe-in -68.95, -22.53 -32.12, -48.44 APE12-dist-out 14.308 APE11-dist-in 12.383 APE10-dist-out 8.09 APE9-dist-in 3.641 None None None XRAY 2.598 0.229 0.284 A 490 327 15 0 0 0 [[156, 472]] 1.0 6khf Homo sapiens CMGC_CLK3_HUMAN CMGC 3.4e-90 308.4 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 9EZ3A P49761 136 481 490.0 A1H74:502 Type2 Inactive DFGout 16.998 8.291 None -128.15, 178.46 -155.63, 110.75 -66.24, -31.17 198.15, 50.73 79.35, 999.0 in-in in 8.174 Saltbr-in 3.041 HRD-in -67.98, -56.04 75.99, -25.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.34, 163.79 APE9-dihe-na 74.59, 163.12 APE8-dihe-in -93.15, 147.67 APE8-rot-in 295.87 APE67-dihe-in -65.84, -11.54 -36.31, -63.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.156 None None None XRAY 2.7 0.206 0.268 A 360 335 14 0 0 11 [[156, 472]] 1.0 9ez3 Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.6 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
CLK3_HUMAN 2EXEA P49761 198 479 490.0 No_ligand No_ligand Inactive None 7.649 999.0 None -120.7, 177.41 63.29, 75.6 -91.62, 15.52 299.12, 87.11 -54.14, -25.86 none-none none 999.0 Saltbr-none 999.0 HRD-in -72.06, -50.66 79.06, -17.2 none-in-out SNCnio in-out ActLoopNT-in 2.78 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -135.42, 173.5 APE9-dihe-na 72.68, 152.2 APE8-dihe-in -73.33, 142.23 APE8-rot-in 283.13 APE67-dihe-in -59.06, -21.19 -44.66, -54.89 APE12-dist-out 14.146 APE11-dist-in 12.338 APE10-dist-in 7.66 APE9-dist-in 2.981 None None None XRAY 2.35 0.227 0.26 A 357 262 7 0 0 0 [[156, 472]] 1.0 2exe Homo sapiens CMGC_CLK3_HUMAN CMGC 1.2e-90 309.7 1 301 301 319 320 321 323 325 186 201 205 280 282 281 283 356 344 339 338 337 336 335 334 333 237 Dual specificity protein kinase CLK3
W7JM86_PLAFA 8RPCA W7JM86 40 396 401.0 A1H19:60801 Type1 Inactive DFGin 5.147 12.865 BLAminus -137.44, -172.45 57.01, 70.53 -84.91, 22.11 279.87, 115.6 -66.28, -25.17 in-in in 8.843 Saltbr-in 2.801 HRD-in -69.67, -44.35 59.82, 20.69 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -90.77, 145.91 APE9-dihe-na 78.82, 146.73 APE8-dihe-in -63.8, 131.4 APE8-rot-in 300.27 APE67-dihe-in -60.01, -22.5 -38.63, -53.25 APE12-dist-out 15.578 APE11-dist-in 11.829 APE10-dist-out 8.151 APE9-dist-in 3.176 None PTR228 PTR228 XRAY 2.079 0.202 0.257 A 382 355 0 0 0 0 [[66, 389]] 1.0 8rpc Plasmodium falciparum UGT5.1 CMGC_CLK3_PLAFA CMGC 3.4e-73 252.6 4 301 298 212 213 214 216 218 96 111 115 191 193 192 194 250 238 233 232 231 230 229 228 227 147 non-specific serine/threonine protein kinase

CMGC_CLK3 (Dual specificity protein kinase CLK3)

Total number of chains: 1
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 100.0% 8RPCA

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
W7JM86_PLAFA 8RPCA W7JM86 40 396 401.0 A1H19:60801 Type1 Inactive DFGin 5.147 12.865 BLAminus -137.44, -172.45 57.01, 70.53 -84.91, 22.11 279.87, 115.6 -66.28, -25.17 in-in in 8.843 Saltbr-in 2.801 HRD-in -69.67, -44.35 59.82, 20.69 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -90.77, 145.91 APE9-dihe-na 78.82, 146.73 APE8-dihe-in -63.8, 131.4 APE8-rot-in 300.27 APE67-dihe-in -60.01, -22.5 -38.63, -53.25 APE12-dist-out 15.578 APE11-dist-in 11.829 APE10-dist-out 8.151 APE9-dist-in 3.176 None PTR228 PTR228 XRAY 2.079 0.202 0.257 A 382 355 0 0 0 0 [[66, 389]] 1.0 8rpc Plasmodium falciparum UGT5.1 CMGC_CLK3_PLAFA CMGC 3.4e-73 252.6 4 301 298 212 213 214 216 218 96 111 115 191 193 192 194 250 238 233 232 231 230 229 228 227 147 non-specific serine/threonine protein kinase