Ligand: NJ6

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 8I0LA
DFGin BLBplus 1 50.0% 8I0MA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK6 CDK6_HUMAN 8I0MA 2.777 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaiii APEdist_nnno NJ6 Type1 11 - 301 0 None None Cyclin-dependent kinase 6
CMGC CDK9 CDK9_HUMAN 8I0LA 3.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NJ6 Type1 6 - 326 0 TPO186 None Cyclin-dependent kinase 9

Ligand: NJ6

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 8I0LA
DFGin BLBplus 1 50.0% 8I0MA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK6 CDK6_HUMAN 8I0MA 2.777 Inactive DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaiii APEdist_nnno NJ6 Type1 11 - 301 0 None None Cyclin-dependent kinase 6 Homo sapiens
CMGC CDK9 CDK9_HUMAN 8I0LA 3.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NJ6 Type1 6 - 326 0 TPO186 None Cyclin-dependent kinase 9 Homo sapiens

Ligand: NJ6

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism