CMGC_CDK9 (Cyclin-dependent kinase 9)

Total number of chains: 35
Active chains: 25
Uniprot: CDK9_HUMAN
Kinase Domain Residues: 19 - 315
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 35 100.0% AF-P50750-K1A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK9 3BLQA P50750 7 325 372.0 ATP:332 ATPlike Active DFGin 6.9827 15.2352 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.5144 Saltbr-in 3.2566 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.8505 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.0281 APE11-dist-in 11.0296 APE10-dist-in 6.8964 APE9-dist-in 3.1544 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331.0 296.0 23 32 25 7 [[19, 315]] 1.0 3blq CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4IMYC P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.7892 15.1227 BLAminus -140.61, 175.84 60.41, 77.79 -97.02, 19.01 284.69, 80.72 -68.98, -8.54 in-in in 9.2316 Saltbr-in 2.8334 HRD-in -67.68, -50.97 65.16, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.9277 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.81, 161.81 APE9-dihe-na 73.71, 135.92 APE8-dihe-in -53.34, 141.57 APE8-rot-in 294.85 APE67-dihe-in -61.16, -25.06 -47.9, -50.46 APE12-dist-in 13.386 APE11-dist-in 11.4309 APE10-dist-in 7.0061 APE9-dist-in 3.2788 None TPO186 TPO186 XRAY 2.94 0.209 0.245 C 332.0 311.0 12 32 32 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4IMYE P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.7942 15.1123 BLAminus -141.41, 175.75 59.75, 77.9 -96.66, 19.65 284.44, 80.03 -69.65, -8.18 in-in in 9.1968 Saltbr-in 2.8157 HRD-in -68.02, -51.11 68.06, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.9192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.97, 161.65 APE9-dihe-na 74.14, 135.63 APE8-dihe-in -53.23, 140.74 APE8-rot-in 294.81 APE67-dihe-in -59.86, -25.62 -47.7, -50.88 APE12-dist-in 13.4053 APE11-dist-in 11.4373 APE10-dist-in 7.0102 APE9-dist-in 3.2779 None TPO186 TPO186 XRAY 2.94 0.209 0.245 E 332.0 314.0 9 32 32 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3MIAA P50750 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.0773 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.3135 Saltbr-in 2.6891 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.9572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.2577 APE11-dist-in 11.5238 APE10-dist-in 6.949 APE9-dist-in 3.5228 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351.0 325.0 8 32 32 0 [[19, 315]] 1.0 3mia CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 AF-P50750-K1A P50750 11 323 372.0 No_ligand No_ligand Active DFGin 6.8042 15.1653 BLAminus -137.37, 173.37 64.39, 60.59 -77.02, 16.85 288.83, 77.77 -62.06, -30.21 in-in in 8.5177 Saltbr-in 2.7095 HRD-in -74.93, -50.16 64.15, 10.46 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.96, 171.33 APE9-dihe-na 63.33, 135.53 APE8-dihe-in -59.46, 137.0 APE8-rot-in 298.24 APE67-dihe-in -65.46, -22.86 -48.78, -43.32 APE12-dist-in 13.0722 APE11-dist-in 11.3206 APE10-dist-in 6.6472 APE9-dist-in 3.3315 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 32 32 0 [[19, 315]] 1.0 AF-P50750-K1 CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 AF-P50750-K3A P50750 11 323 372.0 No_ligand No_ligand Active DFGin 7.0625 14.6978 BLAminus -139.94, 174.92 58.53, 50.7 -65.37, 20.59 281.14, 76.16 -63.5, -35.02 in-in in 8.8 Saltbr-in 2.7654 HRD-in -75.68, -48.0 63.0, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.8529 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.22, 172.67 APE9-dihe-na 61.33, 130.24 APE8-dihe-in -58.01, 135.54 APE8-rot-in 298.09 APE67-dihe-in -65.99, -22.34 -47.59, -46.0 APE12-dist-in 12.5857 APE11-dist-in 10.571 APE10-dist-in 6.2046 APE9-dist-in 3.3667 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 32 32 0 [[19, 315]] 1.0 AF-P50750-K3 CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4OR5A P50750 8 331 372.0 No_ligand No_ligand Active DFGin 6.9434 14.7402 BLAminus -124.31, 168.54 69.01, 76.04 -97.31, 28.71 289.03, 30.11 -68.53, -16.51 in-in in 8.9825 Saltbr-in 2.7616 HRD-in -69.96, -55.39 71.5, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.8708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 159.55 APE9-dihe-na 76.25, 129.47 APE8-dihe-in -55.54, 147.57 APE8-rot-in 323.78 APE67-dihe-in -55.49, -19.54 -44.65, -58.02 APE12-dist-in 13.144 APE11-dist-in 10.9027 APE10-dist-in 6.7841 APE9-dist-in 3.2118 None TPO186 TPO186 XRAY 2.9 0.225 0.267 A 326.0 320.0 4 32 32 0 [[19, 315]] 1.0 4or5 CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4OR5F P50750 8 332 372.0 No_ligand No_ligand Active DFGin 6.6679 14.9799 BLAminus -111.52, -176.73 51.04, 89.5 -102.8, 24.68 281.6, 71.85 -49.29, -46.03 in-in in 9.2117 Saltbr-in 2.608 HRD-in -63.05, -54.26 62.81, 29.79 in-in-in SNCiii in-in ActLoopNT-in 2.8771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.12, 165.75 APE9-dihe-na 70.73, 135.03 APE8-dihe-in -51.7, 151.98 APE8-rot-in 310.95 APE67-dihe-in -54.55, -10.13 -58.62, -54.74 APE12-dist-in 12.9476 APE11-dist-in 10.8195 APE10-dist-in 6.5337 APE9-dist-in 3.4429 None TPO186 TPO186 XRAY 2.9 0.225 0.267 F 326.0 325.0 0 32 32 0 [[19, 315]] 1.0 4or5 CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 5L1ZA P50750 8 330 372.0 No_ligand No_ligand Active DFGin 7.2181 14.5988 BLAminus -125.76, -179.91 59.3, 75.76 -100.2, 28.34 287.78, 61.41 -57.18, -56.97 in-in in 8.958 Saltbr-in 2.708 HRD-in -67.89, -46.91 51.73, 43.04 in-in-in SNCiii in-in ActLoopNT-in 2.6341 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 164.45 APE9-dihe-na 64.74, 143.58 APE8-dihe-in -57.19, 139.09 APE8-rot-in 301.99 APE67-dihe-in -68.84, -33.17 -48.82, -40.87 APE12-dist-in 12.9297 APE11-dist-in 10.7466 APE10-dist-in 6.6332 APE9-dist-in 3.47 None TPO186 TPO186 XRAY 5.9 0.217 0.313 A 330.0 311.0 12 32 32 0 [[19, 315]] 1.0 5l1z CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 6CYTA P50750 8 330 372.0 No_ligand No_ligand Active DFGin 7.1285 14.8195 BLAminus -145.42, 171.89 59.31, 72.76 -88.66, 18.9 282.04, 75.69 -58.99, -26.1 in-in in 8.749 Saltbr-in 3.0849 HRD-in -78.56, -48.34 62.81, 28.85 in-in-in SNCiii in-in ActLoopNT-in 2.7696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.32, 170.8 APE9-dihe-na 69.6, 130.71 APE8-dihe-in -52.14, 135.55 APE8-rot-in 303.56 APE67-dihe-in -61.47, -34.74 -50.37, -43.24 APE12-dist-in 13.1576 APE11-dist-in 11.3411 APE10-dist-in 6.7646 APE9-dist-in 3.7581 None TPO186 TPO186 XRAY 3.5 0.251 0.283 A 332.0 319.0 4 32 32 0 [[19, 315]] 1.0 6cyt CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3MI9A P50750 8 344 372.0 No_ligand No_ligand Active DFGin 7.2169 15.0828 BLAminus -131.5, 175.99 56.36, 81.19 -96.49, 22.86 283.32, 81.7 -61.79, -15.23 in-in in 9.3695 Saltbr-in 2.6612 HRD-in -69.68, -51.06 64.68, 15.58 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.92, 157.04 APE9-dihe-na 77.38, 136.99 APE8-dihe-in -56.37, 139.72 APE8-rot-in 276.81 APE67-dihe-in -58.41, -18.53 -45.4, -54.86 APE12-dist-in 13.4809 APE11-dist-in 11.3085 APE10-dist-in 7.2709 APE9-dist-in 3.2694 None TPO186 TPO186 XRAY 2.1 0.219 0.264 A 351.0 329.0 8 32 32 0 [[19, 315]] 1.0 3mi9 CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4EC8A P50750 6 338 372.0 No_ligand No_ligand Active DFGin 7.0211 14.7096 BLAminus -136.31, 174.5 61.51, 81.72 -97.53, 24.16 282.28, 73.66 -54.62, -38.88 in-in in 9.0427 Saltbr-in 2.9411 HRD-in -86.88, -43.45 62.41, 27.26 in-in-in SNCiii in-in ActLoopNT-in 2.8599 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.08, 171.7 APE9-dihe-na 55.16, 133.32 APE8-dihe-in -40.35, 153.59 APE8-rot-in 304.69 APE67-dihe-in -58.26, -42.11 -57.08, -55.81 APE12-dist-in 13.1063 APE11-dist-in 11.158 APE10-dist-in 6.7181 APE9-dist-in 3.2977 None TPO186 TPO186 XRAY 3.6 0.194 0.23 A 373.0 326.0 7 32 32 0 [[19, 315]] 1.0 4ec8 CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4EC9A P50750 7 327 372.0 No_ligand No_ligand Active DFGin 6.9633 15.0312 BLAminus -130.28, 170.97 63.86, 78.14 -96.65, 19.21 284.99, 81.64 -66.97, -16.11 in-in in 9.5023 Saltbr-in 3.1673 HRD-in -77.71, -44.73 68.48, 6.05 in-in-in SNCiii in-in ActLoopNT-in 2.7603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.99, 139.69 APE9-dihe-na 84.51, 133.17 APE8-dihe-in -49.64, 141.35 APE8-rot-in 313.22 APE67-dihe-in -69.04, -23.15 -49.34, -46.9 APE12-dist-in 13.4386 APE11-dist-in 11.2801 APE10-dist-in 7.1746 APE9-dist-in 2.9115 None TPO186 TPO186 XRAY 3.21 0.203 0.233 A 373.0 307.0 14 32 32 0 [[19, 315]] 1.0 4ec9 CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4BCFA P50750 6 326 372.0 T6Q:1327 Type1 Active DFGin 7.0353 15.0056 BLAminus -130.89, 175.85 58.26, 78.19 -93.84, 20.92 284.01, 74.28 -69.0, -18.91 in-in in 9.3848 Saltbr-in 3.4539 HRD-in -78.09, -44.7 68.67, 6.76 in-in-in SNCiii in-in ActLoopNT-in 2.8709 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 149.94 APE9-dihe-na 81.04, 132.5 APE8-dihe-in -49.66, 140.73 APE8-rot-in 291.42 APE67-dihe-in -67.27, -22.18 -50.7, -44.79 APE12-dist-in 13.1043 APE11-dist-in 10.3036 APE10-dist-in 6.9066 APE9-dist-in 3.1282 None TPO186 TPO186 XRAY 3.011 0.169 0.224 A 331.0 308.0 13 32 27 5 [[19, 315]] 1.0 4bcf CMGC_CDK9_HUMAN CMGC 3.7e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 8I0LA P50750 6 326 372.0 NJ6:401 Type1 Active DFGin 7.2933 15.8552 BLAminus -130.69, 179.52 57.03, 69.82 -94.01, 27.86 282.24, 73.6 -69.08, -49.61 in-in in 9.5728 Saltbr-in 3.2346 HRD-in -83.43, -47.61 60.01, 23.96 in-in-in SNCiii in-in ActLoopNT-in 2.7589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.64, 163.64 APE9-dihe-na 68.82, 138.39 APE8-dihe-in -61.18, 156.44 APE8-rot-in 324.35 APE67-dihe-in -70.36, -22.43 -60.05, -41.69 APE12-dist-in 12.8088 APE11-dist-in 10.3473 APE10-dist-in 6.433 APE9-dist-in 3.5487 None TPO186 TPO186 XRAY 3.6 0.235 0.257 A 332.0 308.0 13 32 27 5 [[19, 315]] 1.0 8i0l CMGC_CDK9_HUMAN CMGC 3.8e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 6GZHA P50750 8 326 372.0 LCI:2001 Type1 Active DFGin 6.9623 15.2757 BLAminus -143.64, 171.3 50.95, 83.68 -93.37, 33.37 284.73, 74.17 -64.71, -41.34 in-in in 9.6453 Saltbr-in 2.8862 HRD-in -65.68, -54.2 64.63, 22.42 in-in-in SNCiii in-in ActLoopNT-in 2.7717 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.77, 163.06 APE9-dihe-na 70.11, 142.16 APE8-dihe-in -60.75, 137.92 APE8-rot-in 300.9 APE67-dihe-in -63.71, -23.63 -48.56, -44.41 APE12-dist-in 12.8286 APE11-dist-in 10.3059 APE10-dist-in 6.5798 APE9-dist-in 3.427 None TPO186 TPO186 XRAY 3.17 0.175 0.257 A 326.0 310.0 9 32 29 3 [[19, 315]] 1.0 6gzh CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3LQ5A P50750 6 327 372.0 SLQ:331 Type1 Active DFGin 7.0765 14.8621 BLAminus -142.24, 175.94 56.62, 82.08 -95.24, 28.75 286.71, 83.42 -69.95, -28.82 in-in in 9.1057 Saltbr-in 3.5502 HRD-in -75.08, -43.56 66.05, 12.53 in-in-in SNCiii in-in ActLoopNT-in 2.8596 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.5, 158.49 APE9-dihe-na 76.36, 121.96 APE8-dihe-in -35.3, 136.84 APE8-rot-in 307.0 APE67-dihe-in -57.48, -14.79 -49.62, -56.61 APE12-dist-in 13.1586 APE11-dist-in 10.5202 APE10-dist-in 6.7909 APE9-dist-in 3.5316 None TPO186 TPO186 XRAY 3.0 0.165 0.215 A 331.0 308.0 14 32 28 4 [[19, 315]] 1.0 3lq5 CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3MY1A P50750 6 327 372.0 RFZ:336 Type1 Active DFGin 6.9201 14.7372 BLAminus -138.6, -178.76 55.85, 82.27 -96.58, 26.19 286.18, 71.12 -65.01, -22.99 in-in in 9.1741 Saltbr-in 3.0243 HRD-in -74.76, -49.19 65.23, 25.42 in-in-in SNCiii in-in ActLoopNT-in 2.7707 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.34, 163.18 APE9-dihe-na 70.44, 131.12 APE8-dihe-in -41.78, 152.21 APE8-rot-in 296.57 APE67-dihe-in -62.52, -36.66 -60.91, -51.23 APE12-dist-in 13.127 APE11-dist-in 11.2204 APE10-dist-in 6.8527 APE9-dist-in 3.38 None TPO186 TPO186 XRAY 2.8 0.175 0.214 A 331.0 315.0 7 32 32 0 [[19, 315]] 1.0 3my1 CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3TN8A P50750 8 325 372.0 F18:332 Type1 Active DFGin 6.9278 14.7581 BLAminus -143.85, 178.49 57.5, 79.87 -95.98, 37.06 283.24, 76.06 -66.12, -47.35 in-in in 8.8749 Saltbr-in 3.0787 HRD-in -75.16, -50.1 67.86, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.7428 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.91, 161.16 APE9-dihe-na 76.41, 125.51 APE8-dihe-in -47.81, 145.62 APE8-rot-in 301.4 APE67-dihe-in -65.71, -32.31 -55.05, -44.31 APE12-dist-in 12.8627 APE11-dist-in 10.1967 APE10-dist-in 6.7042 APE9-dist-in 3.1972 None TPO186 TPO186 XRAY 2.95 0.179 0.221 A 331.0 305.0 13 32 28 4 [[19, 315]] 1.0 3tn8 CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3TNHA P50750 8 328 372.0 F18:400 Type1 Active DFGin 6.8947 14.8628 BLAminus -133.46, 172.31 64.77, 76.91 -97.39, 20.03 283.08, 80.82 -68.17, -17.73 in-in in 9.0653 Saltbr-in 3.3429 HRD-in -75.15, -45.06 69.35, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.7866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.95, 145.17 APE9-dihe-na 82.57, 129.21 APE8-dihe-in -52.21, 142.64 APE8-rot-in 282.87 APE67-dihe-in -68.26, -22.31 -48.58, -47.58 APE12-dist-in 12.8501 APE11-dist-in 9.7031 APE10-dist-in 6.8665 APE9-dist-in 3.1983 None TPO186 TPO186 XRAY 3.202 0.179 0.226 A 331.0 289.0 32 32 25 7 [[19, 315]] 1.0 3tnh CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4OGRA P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 6.9587 14.852 BLAminus -145.48, 171.71 58.99, 73.11 -88.05, 19.07 282.19, 75.89 -59.04, -25.77 in-in in 8.622 Saltbr-in 3.2016 HRD-in -78.29, -48.1 62.83, 28.93 in-in-in SNCiii in-in ActLoopNT-in 2.8854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.59, 171.14 APE9-dihe-na 70.34, 130.75 APE8-dihe-in -51.49, 135.3 APE8-rot-in 303.62 APE67-dihe-in -61.39, -34.94 -50.28, -42.94 APE12-dist-in 13.2451 APE11-dist-in 11.4816 APE10-dist-in 6.7057 APE9-dist-in 3.2055 None TPO186 TPO186 XRAY 3.0 0.206 0.232 A 332.0 315.0 8 32 32 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4OGRE P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.086 14.7487 BLAminus -145.95, 172.29 59.47, 72.14 -89.89, 19.36 283.65, 75.49 -58.97, -26.2 in-in in 8.8012 Saltbr-in 2.9314 HRD-in -77.91, -48.96 62.4, 28.78 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.99, 169.74 APE9-dihe-na 65.95, 134.0 APE8-dihe-in -52.43, 138.08 APE8-rot-in 303.65 APE67-dihe-in -62.11, -36.08 -50.82, -43.72 APE12-dist-in 13.2144 APE11-dist-in 11.1773 APE10-dist-in 6.7991 APE9-dist-in 3.4289 None TPO186 TPO186 XRAY 3.0 0.206 0.232 E 332.0 311.0 12 32 32 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4OGRI P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.0203 14.8566 BLAminus -146.32, 171.3 58.62, 73.81 -88.0, 20.33 283.45, 75.93 -58.21, -25.18 in-in in 8.7536 Saltbr-in 3.2525 HRD-in -77.88, -47.68 62.44, 29.24 in-in-in SNCiii in-in ActLoopNT-in 2.9367 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.71, 169.37 APE9-dihe-na 67.96, 131.32 APE8-dihe-in -52.01, 135.85 APE8-rot-in 303.33 APE67-dihe-in -60.26, -34.97 -51.39, -42.17 APE12-dist-in 13.226 APE11-dist-in 11.0359 APE10-dist-in 6.5244 APE9-dist-in 3.1268 None TPO186 TPO186 XRAY 3.0 0.206 0.232 I 332.0 319.0 4 32 32 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 6W9EA P50750 7 326 372.0 TO7:401,TO7:402,TOJ:403,TOJ:404 Type1,Type1,Type1,Type1 Active DFGin 7.0012 15.0826 BLAminus -134.21, 172.07 61.13, 81.04 -94.79, 28.67 292.71, 81.0 -65.23, -42.38 in-in in 9.2262 Saltbr-in 3.0472 HRD-in -77.57, -45.55 60.07, 27.0 in-in-in SNCiii in-in ActLoopNT-in 2.7938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 150.83 APE9-dihe-na 76.33, 139.44 APE8-dihe-in -54.19, 159.88 APE8-rot-in 315.27 APE67-dihe-in -69.62, -18.61 -64.18, -47.28 APE12-dist-in 12.768 APE11-dist-in 10.4653 APE10-dist-in 6.7747 APE9-dist-in 3.4111 None TPO186,SEP306 TPO186,SEP306 XRAY 3.1 0.175 0.221 A 330.0 311.0 9 32 28 4 [[19, 315]] 1.0 6w9e CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4IMYA P50750 8 330 372.0 AMP:401 Type1.5_Back Active DFGin 6.761 15.1264 BLAminus -140.16, 177.94 57.41, 78.2 -96.63, 19.81 285.27, 81.22 -68.88, -9.41 in-in in 9.2269 Saltbr-in 2.8489 HRD-in -67.2, -51.3 65.19, 13.63 in-in-in SNCiii in-in ActLoopNT-in 2.9203 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 161.25 APE9-dihe-na 74.17, 135.57 APE8-dihe-in -52.35, 140.79 APE8-rot-in 295.69 APE67-dihe-in -60.8, -24.95 -48.08, -50.31 APE12-dist-in 13.3896 APE11-dist-in 11.433 APE10-dist-in 7.0087 APE9-dist-in 3.2703 None TPO186 TPO186 XRAY 2.94 0.209 0.245 A 332.0 315.0 8 32 32 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3BLHA P50750 8 325 372.0 No_ligand No_ligand Inactive DFGin 7.1048 15.6174 BLAminus -129.9, 170.98 63.01, 77.18 -97.75, 18.52 284.97, 81.6 -67.67, -17.09 in-out in 9.5979 Saltbr-out 5.6083 HRD-in -77.19, -44.8 68.26, 4.38 out-in-in SNCoii in-in ActLoopNT-in 2.8866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 136.54 APE9-dihe-na 82.17, 131.77 APE8-dihe-in -51.9, 141.65 APE8-rot-in 281.88 APE67-dihe-in -68.04, -21.93 -48.78, -46.05 APE12-dist-in 13.0968 APE11-dist-in 9.6899 APE10-dist-in 7.388 APE9-dist-in 3.169 None TPO186 TPO186 XRAY 2.48 0.179 0.221 A 331.0 292.0 26 32 27 5 [[19, 315]] 1.0 3blh CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3TNIA P50750 7 325 372.0 No_ligand No_ligand Inactive DFGin 6.96 15.518 BLAminus -129.67, 172.05 64.93, 76.48 -99.12, 16.83 286.41, 84.44 -68.12, -14.55 in-out in 9.8121 Saltbr-out 6.5193 HRD-in -78.02, -45.15 68.07, 5.47 out-in-in SNCoii in-in ActLoopNT-in 2.8279 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 143.65 APE9-dihe-na 85.09, 131.61 APE8-dihe-in -49.91, 142.7 APE8-rot-in 287.18 APE67-dihe-in -68.03, -22.83 -48.7, -45.44 APE12-dist-in 13.3894 APE11-dist-in 11.0956 APE10-dist-in 7.2647 APE9-dist-in 3.2455 None TPO186 TPO186 XRAY 3.234 0.166 0.21 A 331.0 298.0 21 32 26 6 [[19, 315]] 1.0 3tni CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 7NWKA P50750 7 326 372.0 UT5:401 Type1 Inactive DFGin 7.1109 14.9906 BLAminus -124.85, 176.65 53.29, 84.25 -99.42, 22.06 284.43, 78.88 -62.72, -24.1 in-in in 9.1877 Saltbr-in 3.3558 HRD-in -72.75, -46.7 63.63, 12.3 in-in-out SNCiio in-out ActLoopNT-in 2.8186 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.99, 150.18 APE9-dihe-na 74.8, 134.0 APE8-dihe-in -57.76, 142.58 APE8-rot-out 9.44 APE67-dihe-in -60.65, -26.29 -46.55, -51.52 APE12-dist-in 12.9152 APE11-dist-in 10.2988 APE10-dist-in 6.8276 APE9-dist-in 3.3596 None TPO186 TPO186 XRAY 2.81 0.182 0.205 A 330.0 298.0 22 32 27 5 [[19, 315]] 1.0 7nwk CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 3BLRA P50750 7 326 372.0 CPB:940 Type1 Inactive DFGin 6.8488 14.9826 BLAminus -137.81, 169.59 65.05, 86.98 -102.47, 22.09 282.73, 80.55 -59.33, -27.76 in-in in 9.7301 Saltbr-in 3.0001 HRD-in -77.6, -52.79 69.15, 9.31 in-in-out SNCiio in-out ActLoopNT-in 2.8378 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.25, 157.8 APE9-dihe-na 74.85, 130.66 APE8-dihe-in -57.24, 143.32 APE8-rot-out 21.76 APE67-dihe-in -65.59, -31.38 -41.87, -49.24 APE12-dist-in 13.1889 APE11-dist-in 10.8377 APE10-dist-in 6.8504 APE9-dist-in 3.3621 None TPO186 TPO186 XRAY 2.8 0.176 0.228 A 331.0 301.0 19 32 28 4 [[19, 315]] 1.0 3blr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4BCGA P50750 7 327 372.0 T3C:1328 Type1 Inactive DFGin 7.1337 15.2439 BLAminus -132.48, 173.97 58.32, 78.23 -93.26, 24.05 284.24, 75.68 -68.96, -23.34 in-out in 9.462 Saltbr-out 4.6472 HRD-in -78.18, -44.27 68.6, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.8777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.1, 147.31 APE9-dihe-na 81.87, 132.15 APE8-dihe-in -51.72, 141.44 APE8-rot-in 291.43 APE67-dihe-in -63.63, -25.74 -50.67, -46.04 APE12-dist-in 13.1093 APE11-dist-in 10.2311 APE10-dist-in 6.9327 APE9-dist-in 3.1792 None TPO186 TPO186 XRAY 3.085 0.163 0.197 A 331.0 313.0 8 32 32 0 [[19, 315]] 1.0 4bcg CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4BCHA P50750 7 327 372.0 T7Z:1328 Type1 Inactive DFGin 7.0222 15.2506 BLAminus -131.52, 173.1 62.62, 79.06 -97.34, 18.94 284.72, 72.84 -65.45, -18.12 in-out in 9.5639 Saltbr-out 4.3367 HRD-in -78.74, -44.37 68.53, 5.43 out-in-in SNCoii in-in ActLoopNT-in 2.9166 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.64, 156.76 APE9-dihe-na 81.03, 133.91 APE8-dihe-in -51.15, 142.4 APE8-rot-in 295.91 APE67-dihe-in -66.84, -22.68 -48.59, -47.41 APE12-dist-in 13.2669 APE11-dist-in 10.899 APE10-dist-in 6.9125 APE9-dist-in 3.1811 None TPO186 TPO186 XRAY 2.958 0.169 0.21 A 331.0 309.0 12 32 27 5 [[19, 315]] 1.0 4bch CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4BCIA P50750 5 326 372.0 T3E:1327 Type1 Inactive DFGin 7.0993 15.1819 BLAminus -131.07, 172.91 63.16, 77.79 -97.71, 24.25 283.9, 77.6 -66.92, -23.58 in-out in 9.472 Saltbr-out 4.196 HRD-in -77.09, -44.37 66.65, 15.51 out-in-in SNCoii in-in ActLoopNT-in 2.8874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.81, 155.45 APE9-dihe-na 82.12, 132.8 APE8-dihe-in -46.04, 142.98 APE8-rot-in 310.28 APE67-dihe-in -70.86, -24.72 -49.47, -47.11 APE12-dist-in 13.1009 APE11-dist-in 11.1559 APE10-dist-in 6.8281 APE9-dist-in 3.348 None TPO186 TPO186 XRAY 3.1 0.18 0.221 A 331.0 309.0 13 32 28 4 [[19, 315]] 1.0 4bci CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 4BCJA P50750 6 326 372.0 T9N:1327 Type1 Inactive DFGin 7.0297 15.0182 BLAminus -131.0, 170.86 63.37, 81.25 -96.53, 22.01 287.4, 63.38 -57.12, -37.16 in-out in 9.444 Saltbr-out 4.4548 HRD-in -79.62, -45.57 66.85, 8.76 out-in-in SNCoii in-in ActLoopNT-in 2.8731 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.55, 158.16 APE9-dihe-na 80.36, 134.65 APE8-dihe-in -47.14, 141.93 APE8-rot-in 299.93 APE67-dihe-in -67.12, -25.13 -50.6, -47.83 APE12-dist-in 13.0964 APE11-dist-in 11.1084 APE10-dist-in 6.8405 APE9-dist-in 3.158 None TPO186 TPO186 XRAY 3.162 0.162 0.207 A 331.0 310.0 11 32 28 4 [[19, 315]] 1.0 4bcj CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 8K5RA P50750 5 327 372.0 VQE:401 Type1 Inactive DFGin 7.5425 15.4625 BLAminus -127.7, -178.83 57.51, 52.57 -82.11, 20.94 280.63, 64.24 -61.34, -43.86 in-out in 9.2916 Saltbr-out 3.7162 HRD-in -86.18, -55.67 72.35, 16.43 out-in-in SNCoii in-in ActLoopNT-in 2.7091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 166.1 APE9-dihe-na 82.22, 165.84 APE8-dihe-in -71.04, 149.98 APE8-rot-in 312.55 APE67-dihe-in -65.92, -42.72 -67.97, -33.99 APE12-dist-in 12.9159 APE11-dist-in 11.442 APE10-dist-in 6.8195 APE9-dist-in 3.1643 S7D,V8N,K44R,Y138F,K280A,D307E,N311E TPO186 TPO186 XRAY 3.751 0.203 0.245 A 330.0 306.0 17 32 29 3 [[19, 315]] 1.0 8k5r CMGC_CDK9_HUMAN CMGC 9.7e-80 273.9 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 6Z45A P50750 5 328 372.0 Q6E:401 Type1 Inactive DFGin 7.3169 14.744 BLAminus -124.48, 171.21 57.13, 81.63 -95.68, 19.28 282.63, 77.61 -65.74, -21.16 in-in in 9.0922 Saltbr-in 3.4414 HRD-in -72.24, -47.68 66.59, 11.95 in-in-out SNCiio in-out ActLoopNT-in 2.8243 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.93, 143.26 APE9-dihe-na 76.68, 135.99 APE8-dihe-in -63.34, 144.14 APE8-rot-out 73.55 APE67-dihe-in -62.15, -25.5 -46.95, -49.84 APE12-dist-in 13.0787 APE11-dist-in 9.9703 APE10-dist-in 7.1918 APE9-dist-in 3.3261 None TPO186 TPO186 XRAY 3.37 0.174 0.188 A 330.0 314.0 10 32 28 4 [[19, 315]] 1.0 6z45 CMGC_CDK9_HUMAN CMGC 1e-79 273.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9

CMGC_CDK9 (Cyclin-dependent kinase 9)

Total number of chains: 35
Active chains: 25
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 35 100.0% AF-P50750-K1A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK9 CDK9_HUMAN 3BLQA P50750 7 325 372.0 ATP:332 ATPlike Active DFGin 6.9827 15.2352 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.5144 Saltbr-in 3.2566 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.8505 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.0281 APE11-dist-in 11.0296 APE10-dist-in 6.8964 APE9-dist-in 3.1544 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331.0 296.0 23 32 25 7 [[19, 315]] 1.0 3blq Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4IMYC P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.7892 15.1227 BLAminus -140.61, 175.84 60.41, 77.79 -97.02, 19.01 284.69, 80.72 -68.98, -8.54 in-in in 9.2316 Saltbr-in 2.8334 HRD-in -67.68, -50.97 65.16, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.9277 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.81, 161.81 APE9-dihe-na 73.71, 135.92 APE8-dihe-in -53.34, 141.57 APE8-rot-in 294.85 APE67-dihe-in -61.16, -25.06 -47.9, -50.46 APE12-dist-in 13.386 APE11-dist-in 11.4309 APE10-dist-in 7.0061 APE9-dist-in 3.2788 None TPO186 TPO186 XRAY 2.94 0.209 0.245 C 332.0 311.0 12 32 32 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4IMYE P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.7942 15.1123 BLAminus -141.41, 175.75 59.75, 77.9 -96.66, 19.65 284.44, 80.03 -69.65, -8.18 in-in in 9.1968 Saltbr-in 2.8157 HRD-in -68.02, -51.11 68.06, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.9192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.97, 161.65 APE9-dihe-na 74.14, 135.63 APE8-dihe-in -53.23, 140.74 APE8-rot-in 294.81 APE67-dihe-in -59.86, -25.62 -47.7, -50.88 APE12-dist-in 13.4053 APE11-dist-in 11.4373 APE10-dist-in 7.0102 APE9-dist-in 3.2779 None TPO186 TPO186 XRAY 2.94 0.209 0.245 E 332.0 314.0 9 32 32 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3MIAA P50750 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.0773 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.3135 Saltbr-in 2.6891 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.9572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.2577 APE11-dist-in 11.5238 APE10-dist-in 6.949 APE9-dist-in 3.5228 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351.0 325.0 8 32 32 0 [[19, 315]] 1.0 3mia Homo sapiens CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN AF-P50750-K1A P50750 11 323 372.0 No_ligand No_ligand Active DFGin 6.8042 15.1653 BLAminus -137.37, 173.37 64.39, 60.59 -77.02, 16.85 288.83, 77.77 -62.06, -30.21 in-in in 8.5177 Saltbr-in 2.7095 HRD-in -74.93, -50.16 64.15, 10.46 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.96, 171.33 APE9-dihe-na 63.33, 135.53 APE8-dihe-in -59.46, 137.0 APE8-rot-in 298.24 APE67-dihe-in -65.46, -22.86 -48.78, -43.32 APE12-dist-in 13.0722 APE11-dist-in 11.3206 APE10-dist-in 6.6472 APE9-dist-in 3.3315 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 32 32 0 [[19, 315]] 1.0 AF-P50750-K1 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN AF-P50750-K3A P50750 11 323 372.0 No_ligand No_ligand Active DFGin 7.0625 14.6978 BLAminus -139.94, 174.92 58.53, 50.7 -65.37, 20.59 281.14, 76.16 -63.5, -35.02 in-in in 8.8 Saltbr-in 2.7654 HRD-in -75.68, -48.0 63.0, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.8529 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.22, 172.67 APE9-dihe-na 61.33, 130.24 APE8-dihe-in -58.01, 135.54 APE8-rot-in 298.09 APE67-dihe-in -65.99, -22.34 -47.59, -46.0 APE12-dist-in 12.5857 APE11-dist-in 10.571 APE10-dist-in 6.2046 APE9-dist-in 3.3667 None None None AF2 -1.0 1.0 1.0 A 313.0 313.0 0 32 32 0 [[19, 315]] 1.0 AF-P50750-K3 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4OR5A P50750 8 331 372.0 No_ligand No_ligand Active DFGin 6.9434 14.7402 BLAminus -124.31, 168.54 69.01, 76.04 -97.31, 28.71 289.03, 30.11 -68.53, -16.51 in-in in 8.9825 Saltbr-in 2.7616 HRD-in -69.96, -55.39 71.5, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.8708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 159.55 APE9-dihe-na 76.25, 129.47 APE8-dihe-in -55.54, 147.57 APE8-rot-in 323.78 APE67-dihe-in -55.49, -19.54 -44.65, -58.02 APE12-dist-in 13.144 APE11-dist-in 10.9027 APE10-dist-in 6.7841 APE9-dist-in 3.2118 None TPO186 TPO186 XRAY 2.9 0.225 0.267 A 326.0 320.0 4 32 32 0 [[19, 315]] 1.0 4or5 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4OR5F P50750 8 332 372.0 No_ligand No_ligand Active DFGin 6.6679 14.9799 BLAminus -111.52, -176.73 51.04, 89.5 -102.8, 24.68 281.6, 71.85 -49.29, -46.03 in-in in 9.2117 Saltbr-in 2.608 HRD-in -63.05, -54.26 62.81, 29.79 in-in-in SNCiii in-in ActLoopNT-in 2.8771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.12, 165.75 APE9-dihe-na 70.73, 135.03 APE8-dihe-in -51.7, 151.98 APE8-rot-in 310.95 APE67-dihe-in -54.55, -10.13 -58.62, -54.74 APE12-dist-in 12.9476 APE11-dist-in 10.8195 APE10-dist-in 6.5337 APE9-dist-in 3.4429 None TPO186 TPO186 XRAY 2.9 0.225 0.267 F 326.0 325.0 0 32 32 0 [[19, 315]] 1.0 4or5 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 5L1ZA P50750 8 330 372.0 No_ligand No_ligand Active DFGin 7.2181 14.5988 BLAminus -125.76, -179.91 59.3, 75.76 -100.2, 28.34 287.78, 61.41 -57.18, -56.97 in-in in 8.958 Saltbr-in 2.708 HRD-in -67.89, -46.91 51.73, 43.04 in-in-in SNCiii in-in ActLoopNT-in 2.6341 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 164.45 APE9-dihe-na 64.74, 143.58 APE8-dihe-in -57.19, 139.09 APE8-rot-in 301.99 APE67-dihe-in -68.84, -33.17 -48.82, -40.87 APE12-dist-in 12.9297 APE11-dist-in 10.7466 APE10-dist-in 6.6332 APE9-dist-in 3.47 None TPO186 TPO186 XRAY 5.9 0.217 0.313 A 330.0 311.0 12 32 32 0 [[19, 315]] 1.0 5l1z Homo sapiens CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 6CYTA P50750 8 330 372.0 No_ligand No_ligand Active DFGin 7.1285 14.8195 BLAminus -145.42, 171.89 59.31, 72.76 -88.66, 18.9 282.04, 75.69 -58.99, -26.1 in-in in 8.749 Saltbr-in 3.0849 HRD-in -78.56, -48.34 62.81, 28.85 in-in-in SNCiii in-in ActLoopNT-in 2.7696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.32, 170.8 APE9-dihe-na 69.6, 130.71 APE8-dihe-in -52.14, 135.55 APE8-rot-in 303.56 APE67-dihe-in -61.47, -34.74 -50.37, -43.24 APE12-dist-in 13.1576 APE11-dist-in 11.3411 APE10-dist-in 6.7646 APE9-dist-in 3.7581 None TPO186 TPO186 XRAY 3.5 0.251 0.283 A 332.0 319.0 4 32 32 0 [[19, 315]] 1.0 6cyt Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3MI9A P50750 8 344 372.0 No_ligand No_ligand Active DFGin 7.2169 15.0828 BLAminus -131.5, 175.99 56.36, 81.19 -96.49, 22.86 283.32, 81.7 -61.79, -15.23 in-in in 9.3695 Saltbr-in 2.6612 HRD-in -69.68, -51.06 64.68, 15.58 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.92, 157.04 APE9-dihe-na 77.38, 136.99 APE8-dihe-in -56.37, 139.72 APE8-rot-in 276.81 APE67-dihe-in -58.41, -18.53 -45.4, -54.86 APE12-dist-in 13.4809 APE11-dist-in 11.3085 APE10-dist-in 7.2709 APE9-dist-in 3.2694 None TPO186 TPO186 XRAY 2.1 0.219 0.264 A 351.0 329.0 8 32 32 0 [[19, 315]] 1.0 3mi9 Homo sapiens CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4EC8A P50750 6 338 372.0 No_ligand No_ligand Active DFGin 7.0211 14.7096 BLAminus -136.31, 174.5 61.51, 81.72 -97.53, 24.16 282.28, 73.66 -54.62, -38.88 in-in in 9.0427 Saltbr-in 2.9411 HRD-in -86.88, -43.45 62.41, 27.26 in-in-in SNCiii in-in ActLoopNT-in 2.8599 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.08, 171.7 APE9-dihe-na 55.16, 133.32 APE8-dihe-in -40.35, 153.59 APE8-rot-in 304.69 APE67-dihe-in -58.26, -42.11 -57.08, -55.81 APE12-dist-in 13.1063 APE11-dist-in 11.158 APE10-dist-in 6.7181 APE9-dist-in 3.2977 None TPO186 TPO186 XRAY 3.6 0.194 0.23 A 373.0 326.0 7 32 32 0 [[19, 315]] 1.0 4ec8 Homo sapiens CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4EC9A P50750 7 327 372.0 No_ligand No_ligand Active DFGin 6.9633 15.0312 BLAminus -130.28, 170.97 63.86, 78.14 -96.65, 19.21 284.99, 81.64 -66.97, -16.11 in-in in 9.5023 Saltbr-in 3.1673 HRD-in -77.71, -44.73 68.48, 6.05 in-in-in SNCiii in-in ActLoopNT-in 2.7603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.99, 139.69 APE9-dihe-na 84.51, 133.17 APE8-dihe-in -49.64, 141.35 APE8-rot-in 313.22 APE67-dihe-in -69.04, -23.15 -49.34, -46.9 APE12-dist-in 13.4386 APE11-dist-in 11.2801 APE10-dist-in 7.1746 APE9-dist-in 2.9115 None TPO186 TPO186 XRAY 3.21 0.203 0.233 A 373.0 307.0 14 32 32 0 [[19, 315]] 1.0 4ec9 Homo sapiens CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4BCFA P50750 6 326 372.0 T6Q:1327 Type1 Active DFGin 7.0353 15.0056 BLAminus -130.89, 175.85 58.26, 78.19 -93.84, 20.92 284.01, 74.28 -69.0, -18.91 in-in in 9.3848 Saltbr-in 3.4539 HRD-in -78.09, -44.7 68.67, 6.76 in-in-in SNCiii in-in ActLoopNT-in 2.8709 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 149.94 APE9-dihe-na 81.04, 132.5 APE8-dihe-in -49.66, 140.73 APE8-rot-in 291.42 APE67-dihe-in -67.27, -22.18 -50.7, -44.79 APE12-dist-in 13.1043 APE11-dist-in 10.3036 APE10-dist-in 6.9066 APE9-dist-in 3.1282 None TPO186 TPO186 XRAY 3.011 0.169 0.224 A 331.0 308.0 13 32 27 5 [[19, 315]] 1.0 4bcf Homo sapiens CMGC_CDK9_HUMAN CMGC 3.7e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 8I0LA P50750 6 326 372.0 NJ6:401 Type1 Active DFGin 7.2933 15.8552 BLAminus -130.69, 179.52 57.03, 69.82 -94.01, 27.86 282.24, 73.6 -69.08, -49.61 in-in in 9.5728 Saltbr-in 3.2346 HRD-in -83.43, -47.61 60.01, 23.96 in-in-in SNCiii in-in ActLoopNT-in 2.7589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.64, 163.64 APE9-dihe-na 68.82, 138.39 APE8-dihe-in -61.18, 156.44 APE8-rot-in 324.35 APE67-dihe-in -70.36, -22.43 -60.05, -41.69 APE12-dist-in 12.8088 APE11-dist-in 10.3473 APE10-dist-in 6.433 APE9-dist-in 3.5487 None TPO186 TPO186 XRAY 3.6 0.235 0.257 A 332.0 308.0 13 32 27 5 [[19, 315]] 1.0 8i0l Homo sapiens CMGC_CDK9_HUMAN CMGC 3.8e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 6GZHA P50750 8 326 372.0 LCI:2001 Type1 Active DFGin 6.9623 15.2757 BLAminus -143.64, 171.3 50.95, 83.68 -93.37, 33.37 284.73, 74.17 -64.71, -41.34 in-in in 9.6453 Saltbr-in 2.8862 HRD-in -65.68, -54.2 64.63, 22.42 in-in-in SNCiii in-in ActLoopNT-in 2.7717 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.77, 163.06 APE9-dihe-na 70.11, 142.16 APE8-dihe-in -60.75, 137.92 APE8-rot-in 300.9 APE67-dihe-in -63.71, -23.63 -48.56, -44.41 APE12-dist-in 12.8286 APE11-dist-in 10.3059 APE10-dist-in 6.5798 APE9-dist-in 3.427 None TPO186 TPO186 XRAY 3.17 0.175 0.257 A 326.0 310.0 9 32 29 3 [[19, 315]] 1.0 6gzh Homo sapiens CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3LQ5A P50750 6 327 372.0 SLQ:331 Type1 Active DFGin 7.0765 14.8621 BLAminus -142.24, 175.94 56.62, 82.08 -95.24, 28.75 286.71, 83.42 -69.95, -28.82 in-in in 9.1057 Saltbr-in 3.5502 HRD-in -75.08, -43.56 66.05, 12.53 in-in-in SNCiii in-in ActLoopNT-in 2.8596 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.5, 158.49 APE9-dihe-na 76.36, 121.96 APE8-dihe-in -35.3, 136.84 APE8-rot-in 307.0 APE67-dihe-in -57.48, -14.79 -49.62, -56.61 APE12-dist-in 13.1586 APE11-dist-in 10.5202 APE10-dist-in 6.7909 APE9-dist-in 3.5316 None TPO186 TPO186 XRAY 3.0 0.165 0.215 A 331.0 308.0 14 32 28 4 [[19, 315]] 1.0 3lq5 Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3MY1A P50750 6 327 372.0 RFZ:336 Type1 Active DFGin 6.9201 14.7372 BLAminus -138.6, -178.76 55.85, 82.27 -96.58, 26.19 286.18, 71.12 -65.01, -22.99 in-in in 9.1741 Saltbr-in 3.0243 HRD-in -74.76, -49.19 65.23, 25.42 in-in-in SNCiii in-in ActLoopNT-in 2.7707 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.34, 163.18 APE9-dihe-na 70.44, 131.12 APE8-dihe-in -41.78, 152.21 APE8-rot-in 296.57 APE67-dihe-in -62.52, -36.66 -60.91, -51.23 APE12-dist-in 13.127 APE11-dist-in 11.2204 APE10-dist-in 6.8527 APE9-dist-in 3.38 None TPO186 TPO186 XRAY 2.8 0.175 0.214 A 331.0 315.0 7 32 32 0 [[19, 315]] 1.0 3my1 Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3TN8A P50750 8 325 372.0 F18:332 Type1 Active DFGin 6.9278 14.7581 BLAminus -143.85, 178.49 57.5, 79.87 -95.98, 37.06 283.24, 76.06 -66.12, -47.35 in-in in 8.8749 Saltbr-in 3.0787 HRD-in -75.16, -50.1 67.86, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.7428 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.91, 161.16 APE9-dihe-na 76.41, 125.51 APE8-dihe-in -47.81, 145.62 APE8-rot-in 301.4 APE67-dihe-in -65.71, -32.31 -55.05, -44.31 APE12-dist-in 12.8627 APE11-dist-in 10.1967 APE10-dist-in 6.7042 APE9-dist-in 3.1972 None TPO186 TPO186 XRAY 2.95 0.179 0.221 A 331.0 305.0 13 32 28 4 [[19, 315]] 1.0 3tn8 Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3TNHA P50750 8 328 372.0 F18:400 Type1 Active DFGin 6.8947 14.8628 BLAminus -133.46, 172.31 64.77, 76.91 -97.39, 20.03 283.08, 80.82 -68.17, -17.73 in-in in 9.0653 Saltbr-in 3.3429 HRD-in -75.15, -45.06 69.35, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.7866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.95, 145.17 APE9-dihe-na 82.57, 129.21 APE8-dihe-in -52.21, 142.64 APE8-rot-in 282.87 APE67-dihe-in -68.26, -22.31 -48.58, -47.58 APE12-dist-in 12.8501 APE11-dist-in 9.7031 APE10-dist-in 6.8665 APE9-dist-in 3.1983 None TPO186 TPO186 XRAY 3.202 0.179 0.226 A 331.0 289.0 32 32 25 7 [[19, 315]] 1.0 3tnh Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4OGRA P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 6.9587 14.852 BLAminus -145.48, 171.71 58.99, 73.11 -88.05, 19.07 282.19, 75.89 -59.04, -25.77 in-in in 8.622 Saltbr-in 3.2016 HRD-in -78.29, -48.1 62.83, 28.93 in-in-in SNCiii in-in ActLoopNT-in 2.8854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.59, 171.14 APE9-dihe-na 70.34, 130.75 APE8-dihe-in -51.49, 135.3 APE8-rot-in 303.62 APE67-dihe-in -61.39, -34.94 -50.28, -42.94 APE12-dist-in 13.2451 APE11-dist-in 11.4816 APE10-dist-in 6.7057 APE9-dist-in 3.2055 None TPO186 TPO186 XRAY 3.0 0.206 0.232 A 332.0 315.0 8 32 32 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4OGRE P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.086 14.7487 BLAminus -145.95, 172.29 59.47, 72.14 -89.89, 19.36 283.65, 75.49 -58.97, -26.2 in-in in 8.8012 Saltbr-in 2.9314 HRD-in -77.91, -48.96 62.4, 28.78 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.99, 169.74 APE9-dihe-na 65.95, 134.0 APE8-dihe-in -52.43, 138.08 APE8-rot-in 303.65 APE67-dihe-in -62.11, -36.08 -50.82, -43.72 APE12-dist-in 13.2144 APE11-dist-in 11.1773 APE10-dist-in 6.7991 APE9-dist-in 3.4289 None TPO186 TPO186 XRAY 3.0 0.206 0.232 E 332.0 311.0 12 32 32 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4OGRI P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.0203 14.8566 BLAminus -146.32, 171.3 58.62, 73.81 -88.0, 20.33 283.45, 75.93 -58.21, -25.18 in-in in 8.7536 Saltbr-in 3.2525 HRD-in -77.88, -47.68 62.44, 29.24 in-in-in SNCiii in-in ActLoopNT-in 2.9367 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.71, 169.37 APE9-dihe-na 67.96, 131.32 APE8-dihe-in -52.01, 135.85 APE8-rot-in 303.33 APE67-dihe-in -60.26, -34.97 -51.39, -42.17 APE12-dist-in 13.226 APE11-dist-in 11.0359 APE10-dist-in 6.5244 APE9-dist-in 3.1268 None TPO186 TPO186 XRAY 3.0 0.206 0.232 I 332.0 319.0 4 32 32 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 6W9EA P50750 7 326 372.0 TO7:401,TO7:402,TOJ:403,TOJ:404 Type1,Type1,Type1,Type1 Active DFGin 7.0012 15.0826 BLAminus -134.21, 172.07 61.13, 81.04 -94.79, 28.67 292.71, 81.0 -65.23, -42.38 in-in in 9.2262 Saltbr-in 3.0472 HRD-in -77.57, -45.55 60.07, 27.0 in-in-in SNCiii in-in ActLoopNT-in 2.7938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 150.83 APE9-dihe-na 76.33, 139.44 APE8-dihe-in -54.19, 159.88 APE8-rot-in 315.27 APE67-dihe-in -69.62, -18.61 -64.18, -47.28 APE12-dist-in 12.768 APE11-dist-in 10.4653 APE10-dist-in 6.7747 APE9-dist-in 3.4111 None TPO186,SEP306 TPO186,SEP306 XRAY 3.1 0.175 0.221 A 330.0 311.0 9 32 28 4 [[19, 315]] 1.0 6w9e Homo sapiens CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4IMYA P50750 8 330 372.0 AMP:401 Type1.5_Back Active DFGin 6.761 15.1264 BLAminus -140.16, 177.94 57.41, 78.2 -96.63, 19.81 285.27, 81.22 -68.88, -9.41 in-in in 9.2269 Saltbr-in 2.8489 HRD-in -67.2, -51.3 65.19, 13.63 in-in-in SNCiii in-in ActLoopNT-in 2.9203 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 161.25 APE9-dihe-na 74.17, 135.57 APE8-dihe-in -52.35, 140.79 APE8-rot-in 295.69 APE67-dihe-in -60.8, -24.95 -48.08, -50.31 APE12-dist-in 13.3896 APE11-dist-in 11.433 APE10-dist-in 7.0087 APE9-dist-in 3.2703 None TPO186 TPO186 XRAY 2.94 0.209 0.245 A 332.0 315.0 8 32 32 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3BLHA P50750 8 325 372.0 No_ligand No_ligand Inactive DFGin 7.1048 15.6174 BLAminus -129.9, 170.98 63.01, 77.18 -97.75, 18.52 284.97, 81.6 -67.67, -17.09 in-out in 9.5979 Saltbr-out 5.6083 HRD-in -77.19, -44.8 68.26, 4.38 out-in-in SNCoii in-in ActLoopNT-in 2.8866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 136.54 APE9-dihe-na 82.17, 131.77 APE8-dihe-in -51.9, 141.65 APE8-rot-in 281.88 APE67-dihe-in -68.04, -21.93 -48.78, -46.05 APE12-dist-in 13.0968 APE11-dist-in 9.6899 APE10-dist-in 7.388 APE9-dist-in 3.169 None TPO186 TPO186 XRAY 2.48 0.179 0.221 A 331.0 292.0 26 32 27 5 [[19, 315]] 1.0 3blh Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3TNIA P50750 7 325 372.0 No_ligand No_ligand Inactive DFGin 6.96 15.518 BLAminus -129.67, 172.05 64.93, 76.48 -99.12, 16.83 286.41, 84.44 -68.12, -14.55 in-out in 9.8121 Saltbr-out 6.5193 HRD-in -78.02, -45.15 68.07, 5.47 out-in-in SNCoii in-in ActLoopNT-in 2.8279 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 143.65 APE9-dihe-na 85.09, 131.61 APE8-dihe-in -49.91, 142.7 APE8-rot-in 287.18 APE67-dihe-in -68.03, -22.83 -48.7, -45.44 APE12-dist-in 13.3894 APE11-dist-in 11.0956 APE10-dist-in 7.2647 APE9-dist-in 3.2455 None TPO186 TPO186 XRAY 3.234 0.166 0.21 A 331.0 298.0 21 32 26 6 [[19, 315]] 1.0 3tni Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 7NWKA P50750 7 326 372.0 UT5:401 Type1 Inactive DFGin 7.1109 14.9906 BLAminus -124.85, 176.65 53.29, 84.25 -99.42, 22.06 284.43, 78.88 -62.72, -24.1 in-in in 9.1877 Saltbr-in 3.3558 HRD-in -72.75, -46.7 63.63, 12.3 in-in-out SNCiio in-out ActLoopNT-in 2.8186 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.99, 150.18 APE9-dihe-na 74.8, 134.0 APE8-dihe-in -57.76, 142.58 APE8-rot-out 9.44 APE67-dihe-in -60.65, -26.29 -46.55, -51.52 APE12-dist-in 12.9152 APE11-dist-in 10.2988 APE10-dist-in 6.8276 APE9-dist-in 3.3596 None TPO186 TPO186 XRAY 2.81 0.182 0.205 A 330.0 298.0 22 32 27 5 [[19, 315]] 1.0 7nwk Homo sapiens CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 3BLRA P50750 7 326 372.0 CPB:940 Type1 Inactive DFGin 6.8488 14.9826 BLAminus -137.81, 169.59 65.05, 86.98 -102.47, 22.09 282.73, 80.55 -59.33, -27.76 in-in in 9.7301 Saltbr-in 3.0001 HRD-in -77.6, -52.79 69.15, 9.31 in-in-out SNCiio in-out ActLoopNT-in 2.8378 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.25, 157.8 APE9-dihe-na 74.85, 130.66 APE8-dihe-in -57.24, 143.32 APE8-rot-out 21.76 APE67-dihe-in -65.59, -31.38 -41.87, -49.24 APE12-dist-in 13.1889 APE11-dist-in 10.8377 APE10-dist-in 6.8504 APE9-dist-in 3.3621 None TPO186 TPO186 XRAY 2.8 0.176 0.228 A 331.0 301.0 19 32 28 4 [[19, 315]] 1.0 3blr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4BCGA P50750 7 327 372.0 T3C:1328 Type1 Inactive DFGin 7.1337 15.2439 BLAminus -132.48, 173.97 58.32, 78.23 -93.26, 24.05 284.24, 75.68 -68.96, -23.34 in-out in 9.462 Saltbr-out 4.6472 HRD-in -78.18, -44.27 68.6, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.8777 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.1, 147.31 APE9-dihe-na 81.87, 132.15 APE8-dihe-in -51.72, 141.44 APE8-rot-in 291.43 APE67-dihe-in -63.63, -25.74 -50.67, -46.04 APE12-dist-in 13.1093 APE11-dist-in 10.2311 APE10-dist-in 6.9327 APE9-dist-in 3.1792 None TPO186 TPO186 XRAY 3.085 0.163 0.197 A 331.0 313.0 8 32 32 0 [[19, 315]] 1.0 4bcg Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4BCHA P50750 7 327 372.0 T7Z:1328 Type1 Inactive DFGin 7.0222 15.2506 BLAminus -131.52, 173.1 62.62, 79.06 -97.34, 18.94 284.72, 72.84 -65.45, -18.12 in-out in 9.5639 Saltbr-out 4.3367 HRD-in -78.74, -44.37 68.53, 5.43 out-in-in SNCoii in-in ActLoopNT-in 2.9166 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.64, 156.76 APE9-dihe-na 81.03, 133.91 APE8-dihe-in -51.15, 142.4 APE8-rot-in 295.91 APE67-dihe-in -66.84, -22.68 -48.59, -47.41 APE12-dist-in 13.2669 APE11-dist-in 10.899 APE10-dist-in 6.9125 APE9-dist-in 3.1811 None TPO186 TPO186 XRAY 2.958 0.169 0.21 A 331.0 309.0 12 32 27 5 [[19, 315]] 1.0 4bch Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4BCIA P50750 5 326 372.0 T3E:1327 Type1 Inactive DFGin 7.0993 15.1819 BLAminus -131.07, 172.91 63.16, 77.79 -97.71, 24.25 283.9, 77.6 -66.92, -23.58 in-out in 9.472 Saltbr-out 4.196 HRD-in -77.09, -44.37 66.65, 15.51 out-in-in SNCoii in-in ActLoopNT-in 2.8874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.81, 155.45 APE9-dihe-na 82.12, 132.8 APE8-dihe-in -46.04, 142.98 APE8-rot-in 310.28 APE67-dihe-in -70.86, -24.72 -49.47, -47.11 APE12-dist-in 13.1009 APE11-dist-in 11.1559 APE10-dist-in 6.8281 APE9-dist-in 3.348 None TPO186 TPO186 XRAY 3.1 0.18 0.221 A 331.0 309.0 13 32 28 4 [[19, 315]] 1.0 4bci Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 4BCJA P50750 6 326 372.0 T9N:1327 Type1 Inactive DFGin 7.0297 15.0182 BLAminus -131.0, 170.86 63.37, 81.25 -96.53, 22.01 287.4, 63.38 -57.12, -37.16 in-out in 9.444 Saltbr-out 4.4548 HRD-in -79.62, -45.57 66.85, 8.76 out-in-in SNCoii in-in ActLoopNT-in 2.8731 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.55, 158.16 APE9-dihe-na 80.36, 134.65 APE8-dihe-in -47.14, 141.93 APE8-rot-in 299.93 APE67-dihe-in -67.12, -25.13 -50.6, -47.83 APE12-dist-in 13.0964 APE11-dist-in 11.1084 APE10-dist-in 6.8405 APE9-dist-in 3.158 None TPO186 TPO186 XRAY 3.162 0.162 0.207 A 331.0 310.0 11 32 28 4 [[19, 315]] 1.0 4bcj Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 8K5RA P50750 5 327 372.0 VQE:401 Type1 Inactive DFGin 7.5425 15.4625 BLAminus -127.7, -178.83 57.51, 52.57 -82.11, 20.94 280.63, 64.24 -61.34, -43.86 in-out in 9.2916 Saltbr-out 3.7162 HRD-in -86.18, -55.67 72.35, 16.43 out-in-in SNCoii in-in ActLoopNT-in 2.7091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 166.1 APE9-dihe-na 82.22, 165.84 APE8-dihe-in -71.04, 149.98 APE8-rot-in 312.55 APE67-dihe-in -65.92, -42.72 -67.97, -33.99 APE12-dist-in 12.9159 APE11-dist-in 11.442 APE10-dist-in 6.8195 APE9-dist-in 3.1643 S7D,V8N,K44R,Y138F,K280A,D307E,N311E TPO186 TPO186 XRAY 3.751 0.203 0.245 A 330.0 306.0 17 32 29 3 [[19, 315]] 1.0 8k5r Homo sapiens CMGC_CDK9_HUMAN CMGC 9.7e-80 273.9 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9 CDK9_HUMAN 6Z45A P50750 5 328 372.0 Q6E:401 Type1 Inactive DFGin 7.3169 14.744 BLAminus -124.48, 171.21 57.13, 81.63 -95.68, 19.28 282.63, 77.61 -65.74, -21.16 in-in in 9.0922 Saltbr-in 3.4414 HRD-in -72.24, -47.68 66.59, 11.95 in-in-out SNCiio in-out ActLoopNT-in 2.8243 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.93, 143.26 APE9-dihe-na 76.68, 135.99 APE8-dihe-in -63.34, 144.14 APE8-rot-out 73.55 APE67-dihe-in -62.15, -25.5 -46.95, -49.84 APE12-dist-in 13.0787 APE11-dist-in 9.9703 APE10-dist-in 7.1918 APE9-dist-in 3.3261 None TPO186 TPO186 XRAY 3.37 0.174 0.188 A 330.0 314.0 10 32 28 4 [[19, 315]] 1.0 6z45 Homo sapiens CMGC_CDK9_HUMAN CMGC 1e-79 273.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9

CMGC_CDK9 (Cyclin-dependent kinase 9)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name