CMGC_CDK9 (Cyclin-dependent kinase 9)

Total number of chains: 35
Active chains: 25
Family: CMGC
Uniprot: CDK9_HUMAN
Kinase Domain Residues: 19 - 315
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 35 100.0% AF-P50750-K1A

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
3BLQA 7 325 372.0 ATP:332 ATPlike Active DFGin 6.983 15.235 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.514 Saltbr-in 3.257 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.028 APE11-dist-in 11.03 APE10-dist-in 6.896 APE9-dist-in 3.154 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331 296 23 0 0 7 [[19, 315]] 1.0 3blq CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4IMYC 8 330 372.0 AMP:401 ATPlike Active DFGin 6.789 15.123 BLAminus -140.61, 175.84 60.41, 77.79 -97.02, 19.01 284.69, 80.72 -68.98, -8.54 in-in in 9.232 Saltbr-in 2.833 HRD-in -67.68, -50.97 65.16, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.81, 161.81 APE9-dihe-na 73.71, 135.92 APE8-dihe-in -53.34, 141.57 APE8-rot-in 294.85 APE67-dihe-in -61.16, -25.06 -47.9, -50.46 APE12-dist-in 13.386 APE11-dist-in 11.431 APE10-dist-in 7.006 APE9-dist-in 3.279 None TPO186 TPO186 XRAY 2.94 0.209 0.245 C 332 311 12 0 0 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4IMYE 8 330 372.0 AMP:401 ATPlike Active DFGin 6.794 15.112 BLAminus -141.41, 175.75 59.75, 77.9 -96.66, 19.65 284.44, 80.03 -69.65, -8.18 in-in in 9.197 Saltbr-in 2.816 HRD-in -68.02, -51.11 68.06, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.97, 161.65 APE9-dihe-na 74.14, 135.63 APE8-dihe-in -53.23, 140.74 APE8-rot-in 294.81 APE67-dihe-in -59.86, -25.62 -47.7, -50.88 APE12-dist-in 13.405 APE11-dist-in 11.437 APE10-dist-in 7.01 APE9-dist-in 3.278 None TPO186 TPO186 XRAY 2.94 0.209 0.245 E 332 314 9 0 0 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3MIAA 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.077 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.313 Saltbr-in 2.689 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.258 APE11-dist-in 11.524 APE10-dist-in 6.949 APE9-dist-in 3.523 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351 325 8 0 0 0 [[19, 315]] 1.0 3mia CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
AF-P50750-K1A 11 323 372.0 No_ligand No_ligand Active DFGin 6.804 15.165 BLAminus -137.37, 173.37 64.39, 60.59 -77.02, 16.85 288.83, 77.77 -62.06, -30.21 in-in in 8.518 Saltbr-in 2.709 HRD-in -74.93, -50.16 64.15, 10.46 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.96, 171.33 APE9-dihe-na 63.33, 135.53 APE8-dihe-in -59.46, 137.0 APE8-rot-in 298.24 APE67-dihe-in -65.46, -22.86 -48.78, -43.32 APE12-dist-in 13.072 APE11-dist-in 11.321 APE10-dist-in 6.647 APE9-dist-in 3.332 None None None AF2 -1.0 1.0 1.0 A 313 313 0 0 0 0 [[19, 315]] 1.0 AF-P50750-K1 CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
AF-P50750-K3A 11 323 372.0 No_ligand No_ligand Active DFGin 7.062 14.698 BLAminus -139.94, 174.92 58.53, 50.7 -65.37, 20.59 281.14, 76.16 -63.5, -35.02 in-in in 8.8 Saltbr-in 2.765 HRD-in -75.68, -48.0 63.0, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.22, 172.67 APE9-dihe-na 61.33, 130.24 APE8-dihe-in -58.01, 135.54 APE8-rot-in 298.09 APE67-dihe-in -65.99, -22.34 -47.59, -46.0 APE12-dist-in 12.586 APE11-dist-in 10.571 APE10-dist-in 6.205 APE9-dist-in 3.367 None None None AF2 -1.0 1.0 1.0 A 313 313 0 0 0 0 [[19, 315]] 1.0 AF-P50750-K3 CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4OR5A 8 331 372.0 No_ligand No_ligand Active DFGin 6.943 14.74 BLAminus -124.31, 168.54 69.01, 76.04 -97.31, 28.71 289.03, 30.11 -68.53, -16.51 in-in in 8.982 Saltbr-in 2.762 HRD-in -69.96, -55.39 71.5, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 159.55 APE9-dihe-na 76.25, 129.47 APE8-dihe-in -55.54, 147.57 APE8-rot-in 323.78 APE67-dihe-in -55.49, -19.54 -44.65, -58.02 APE12-dist-in 13.144 APE11-dist-in 10.903 APE10-dist-in 6.784 APE9-dist-in 3.212 None TPO186 TPO186 XRAY 2.9 0.225 0.267 A 326 320 4 0 0 0 [[19, 315]] 1.0 4or5 CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4OR5F 8 332 372.0 No_ligand No_ligand Active DFGin 6.668 14.98 BLAminus -111.52, -176.73 51.04, 89.5 -102.8, 24.68 281.6, 71.85 -49.29, -46.03 in-in in 9.212 Saltbr-in 2.608 HRD-in -63.05, -54.26 62.81, 29.79 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.12, 165.75 APE9-dihe-na 70.73, 135.03 APE8-dihe-in -51.7, 151.98 APE8-rot-in 310.95 APE67-dihe-in -54.55, -10.13 -58.62, -54.74 APE12-dist-in 12.948 APE11-dist-in 10.819 APE10-dist-in 6.534 APE9-dist-in 3.443 None TPO186 TPO186 XRAY 2.9 0.225 0.267 F 326 325 0 0 0 0 [[19, 315]] 1.0 4or5 CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
5L1ZA 8 330 372.0 No_ligand No_ligand Active DFGin 7.218 14.599 BLAminus -125.76, -179.91 59.3, 75.76 -100.2, 28.34 287.78, 61.41 -57.18, -56.97 in-in in 8.958 Saltbr-in 2.708 HRD-in -67.89, -46.91 51.73, 43.04 in-in-in SNCiii in-in ActLoopNT-in 2.634 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 164.45 APE9-dihe-na 64.74, 143.58 APE8-dihe-in -57.19, 139.09 APE8-rot-in 301.99 APE67-dihe-in -68.84, -33.17 -48.82, -40.87 APE12-dist-in 12.93 APE11-dist-in 10.747 APE10-dist-in 6.633 APE9-dist-in 3.47 None TPO186 TPO186 XRAY 5.9 0.217 0.313 A 330 311 12 0 0 0 [[19, 315]] 1.0 5l1z CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
6CYTA 8 330 372.0 No_ligand No_ligand Active DFGin 7.128 14.819 BLAminus -145.42, 171.89 59.31, 72.76 -88.66, 18.9 282.04, 75.69 -58.99, -26.1 in-in in 8.749 Saltbr-in 3.085 HRD-in -78.56, -48.34 62.81, 28.85 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.32, 170.8 APE9-dihe-na 69.6, 130.71 APE8-dihe-in -52.14, 135.55 APE8-rot-in 303.56 APE67-dihe-in -61.47, -34.74 -50.37, -43.24 APE12-dist-in 13.158 APE11-dist-in 11.341 APE10-dist-in 6.765 APE9-dist-in 3.758 None TPO186 TPO186 XRAY 3.5 0.251 0.283 A 332 319 4 0 0 0 [[19, 315]] 1.0 6cyt CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3MI9A 8 344 372.0 No_ligand No_ligand Active DFGin 7.217 15.083 BLAminus -131.5, 175.99 56.36, 81.19 -96.49, 22.86 283.32, 81.7 -61.79, -15.23 in-in in 9.37 Saltbr-in 2.661 HRD-in -69.68, -51.06 64.68, 15.58 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.92, 157.04 APE9-dihe-na 77.38, 136.99 APE8-dihe-in -56.37, 139.72 APE8-rot-in 276.81 APE67-dihe-in -58.41, -18.53 -45.4, -54.86 APE12-dist-in 13.481 APE11-dist-in 11.309 APE10-dist-in 7.271 APE9-dist-in 3.269 None TPO186 TPO186 XRAY 2.1 0.219 0.264 A 351 329 8 0 0 0 [[19, 315]] 1.0 3mi9 CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4EC8A 6 338 372.0 No_ligand No_ligand Active DFGin 7.021 14.71 BLAminus -136.31, 174.5 61.51, 81.72 -97.53, 24.16 282.28, 73.66 -54.62, -38.88 in-in in 9.043 Saltbr-in 2.941 HRD-in -86.88, -43.45 62.41, 27.26 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.08, 171.7 APE9-dihe-na 55.16, 133.32 APE8-dihe-in -40.35, 153.59 APE8-rot-in 304.69 APE67-dihe-in -58.26, -42.11 -57.08, -55.81 APE12-dist-in 13.106 APE11-dist-in 11.158 APE10-dist-in 6.718 APE9-dist-in 3.298 None TPO186 TPO186 XRAY 3.6 0.194 0.23 A 373 326 7 0 0 0 [[19, 315]] 1.0 4ec8 CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4EC9A 7 327 372.0 No_ligand No_ligand Active DFGin 6.963 15.031 BLAminus -130.28, 170.97 63.86, 78.14 -96.65, 19.21 284.99, 81.64 -66.97, -16.11 in-in in 9.502 Saltbr-in 3.167 HRD-in -77.71, -44.73 68.48, 6.05 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.99, 139.69 APE9-dihe-na 84.51, 133.17 APE8-dihe-in -49.64, 141.35 APE8-rot-in 313.22 APE67-dihe-in -69.04, -23.15 -49.34, -46.9 APE12-dist-in 13.439 APE11-dist-in 11.28 APE10-dist-in 7.175 APE9-dist-in 2.912 None TPO186 TPO186 XRAY 3.21 0.203 0.233 A 373 307 14 0 0 0 [[19, 315]] 1.0 4ec9 CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4BCFA 6 326 372.0 T6Q:1327 Type1 Active DFGin 7.035 15.006 BLAminus -130.89, 175.85 58.26, 78.19 -93.84, 20.92 284.01, 74.28 -69.0, -18.91 in-in in 9.385 Saltbr-in 3.454 HRD-in -78.09, -44.7 68.67, 6.76 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 149.94 APE9-dihe-na 81.04, 132.5 APE8-dihe-in -49.66, 140.73 APE8-rot-in 291.42 APE67-dihe-in -67.27, -22.18 -50.7, -44.79 APE12-dist-in 13.104 APE11-dist-in 10.304 APE10-dist-in 6.907 APE9-dist-in 3.128 None TPO186 TPO186 XRAY 3.011 0.169 0.224 A 331 308 13 0 0 5 [[19, 315]] 1.0 4bcf CMGC_CDK9_HUMAN CMGC 3.7e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
8I0LA 6 326 372.0 NJ6:401 Type1 Active DFGin 7.293 15.855 BLAminus -130.69, 179.52 57.03, 69.82 -94.01, 27.86 282.24, 73.6 -69.08, -49.61 in-in in 9.573 Saltbr-in 3.235 HRD-in -83.43, -47.61 60.01, 23.96 in-in-in SNCiii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.64, 163.64 APE9-dihe-na 68.82, 138.39 APE8-dihe-in -61.18, 156.44 APE8-rot-in 324.35 APE67-dihe-in -70.36, -22.43 -60.05, -41.69 APE12-dist-in 12.809 APE11-dist-in 10.347 APE10-dist-in 6.433 APE9-dist-in 3.549 None TPO186 TPO186 XRAY 3.6 0.235 0.257 A 332 308 13 0 0 5 [[19, 315]] 1.0 8i0l CMGC_CDK9_HUMAN CMGC 3.8e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
6GZHA 8 326 372.0 LCI:2001 Type1 Active DFGin 6.962 15.276 BLAminus -143.64, 171.3 50.95, 83.68 -93.37, 33.37 284.73, 74.17 -64.71, -41.34 in-in in 9.645 Saltbr-in 2.886 HRD-in -65.68, -54.2 64.63, 22.42 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.77, 163.06 APE9-dihe-na 70.11, 142.16 APE8-dihe-in -60.75, 137.92 APE8-rot-in 300.9 APE67-dihe-in -63.71, -23.63 -48.56, -44.41 APE12-dist-in 12.829 APE11-dist-in 10.306 APE10-dist-in 6.58 APE9-dist-in 3.427 None TPO186 TPO186 XRAY 3.17 0.175 0.257 A 326 310 9 0 0 3 [[19, 315]] 1.0 6gzh CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3LQ5A 6 327 372.0 SLQ:331 Type1 Active DFGin 7.077 14.862 BLAminus -142.24, 175.94 56.62, 82.08 -95.24, 28.75 286.71, 83.42 -69.95, -28.82 in-in in 9.106 Saltbr-in 3.55 HRD-in -75.08, -43.56 66.05, 12.53 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.5, 158.49 APE9-dihe-na 76.36, 121.96 APE8-dihe-in -35.3, 136.84 APE8-rot-in 307.0 APE67-dihe-in -57.48, -14.79 -49.62, -56.61 APE12-dist-in 13.159 APE11-dist-in 10.52 APE10-dist-in 6.791 APE9-dist-in 3.532 None TPO186 TPO186 XRAY 3.0 0.165 0.215 A 331 308 14 0 0 4 [[19, 315]] 1.0 3lq5 CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3MY1A 6 327 372.0 RFZ:336 Type1 Active DFGin 6.92 14.737 BLAminus -138.6, -178.76 55.85, 82.27 -96.58, 26.19 286.18, 71.12 -65.01, -22.99 in-in in 9.174 Saltbr-in 3.024 HRD-in -74.76, -49.19 65.23, 25.42 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.34, 163.18 APE9-dihe-na 70.44, 131.12 APE8-dihe-in -41.78, 152.21 APE8-rot-in 296.57 APE67-dihe-in -62.52, -36.66 -60.91, -51.23 APE12-dist-in 13.127 APE11-dist-in 11.22 APE10-dist-in 6.853 APE9-dist-in 3.38 None TPO186 TPO186 XRAY 2.8 0.175 0.214 A 331 315 7 0 0 0 [[19, 315]] 1.0 3my1 CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3TN8A 8 325 372.0 F18:332 Type1 Active DFGin 6.928 14.758 BLAminus -143.85, 178.49 57.5, 79.87 -95.98, 37.06 283.24, 76.06 -66.12, -47.35 in-in in 8.875 Saltbr-in 3.079 HRD-in -75.16, -50.1 67.86, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.743 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.91, 161.16 APE9-dihe-na 76.41, 125.51 APE8-dihe-in -47.81, 145.62 APE8-rot-in 301.4 APE67-dihe-in -65.71, -32.31 -55.05, -44.31 APE12-dist-in 12.863 APE11-dist-in 10.197 APE10-dist-in 6.704 APE9-dist-in 3.197 None TPO186 TPO186 XRAY 2.95 0.179 0.221 A 331 305 13 0 0 4 [[19, 315]] 1.0 3tn8 CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3TNHA 8 328 372.0 F18:400 Type1 Active DFGin 6.895 14.863 BLAminus -133.46, 172.31 64.77, 76.91 -97.39, 20.03 283.08, 80.82 -68.17, -17.73 in-in in 9.065 Saltbr-in 3.343 HRD-in -75.15, -45.06 69.35, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.95, 145.17 APE9-dihe-na 82.57, 129.21 APE8-dihe-in -52.21, 142.64 APE8-rot-in 282.87 APE67-dihe-in -68.26, -22.31 -48.58, -47.58 APE12-dist-in 12.85 APE11-dist-in 9.703 APE10-dist-in 6.867 APE9-dist-in 3.198 None TPO186 TPO186 XRAY 3.202 0.179 0.226 A 331 289 32 0 0 7 [[19, 315]] 1.0 3tnh CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4OGRA 8 330 372.0 ADN:60401 Type1 Active DFGin 6.959 14.852 BLAminus -145.48, 171.71 58.99, 73.11 -88.05, 19.07 282.19, 75.89 -59.04, -25.77 in-in in 8.622 Saltbr-in 3.202 HRD-in -78.29, -48.1 62.83, 28.93 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.59, 171.14 APE9-dihe-na 70.34, 130.75 APE8-dihe-in -51.49, 135.3 APE8-rot-in 303.62 APE67-dihe-in -61.39, -34.94 -50.28, -42.94 APE12-dist-in 13.245 APE11-dist-in 11.482 APE10-dist-in 6.706 APE9-dist-in 3.205 None TPO186 TPO186 XRAY 3.0 0.206 0.232 A 332 315 8 0 0 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4OGRE 8 330 372.0 ADN:60401 Type1 Active DFGin 7.086 14.749 BLAminus -145.95, 172.29 59.47, 72.14 -89.89, 19.36 283.65, 75.49 -58.97, -26.2 in-in in 8.801 Saltbr-in 2.931 HRD-in -77.91, -48.96 62.4, 28.78 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.99, 169.74 APE9-dihe-na 65.95, 134.0 APE8-dihe-in -52.43, 138.08 APE8-rot-in 303.65 APE67-dihe-in -62.11, -36.08 -50.82, -43.72 APE12-dist-in 13.214 APE11-dist-in 11.177 APE10-dist-in 6.799 APE9-dist-in 3.429 None TPO186 TPO186 XRAY 3.0 0.206 0.232 E 332 311 12 0 0 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4OGRI 8 330 372.0 ADN:60401 Type1 Active DFGin 7.02 14.857 BLAminus -146.32, 171.3 58.62, 73.81 -88.0, 20.33 283.45, 75.93 -58.21, -25.18 in-in in 8.754 Saltbr-in 3.252 HRD-in -77.88, -47.68 62.44, 29.24 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.71, 169.37 APE9-dihe-na 67.96, 131.32 APE8-dihe-in -52.01, 135.85 APE8-rot-in 303.33 APE67-dihe-in -60.26, -34.97 -51.39, -42.17 APE12-dist-in 13.226 APE11-dist-in 11.036 APE10-dist-in 6.524 APE9-dist-in 3.127 None TPO186 TPO186 XRAY 3.0 0.206 0.232 I 332 319 4 0 0 0 [[19, 315]] 1.0 4ogr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
6W9EA 7 326 372.0 TO7:401,TO7:402,TOJ:403,TOJ:404 Type1,Type1,Type1,Type1 Active DFGin 7.001 15.083 BLAminus -134.21, 172.07 61.13, 81.04 -94.79, 28.67 292.71, 81.0 -65.23, -42.38 in-in in 9.226 Saltbr-in 3.047 HRD-in -77.57, -45.55 60.07, 27.0 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 150.83 APE9-dihe-na 76.33, 139.44 APE8-dihe-in -54.19, 159.88 APE8-rot-in 315.27 APE67-dihe-in -69.62, -18.61 -64.18, -47.28 APE12-dist-in 12.768 APE11-dist-in 10.465 APE10-dist-in 6.775 APE9-dist-in 3.411 None TPO186,SEP306 TPO186,SEP306 XRAY 3.1 0.175 0.221 A 330 311 9 0 0 4 [[19, 315]] 1.0 6w9e CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4IMYA 8 330 372.0 AMP:401 Type1.5_Back Active DFGin 6.761 15.126 BLAminus -140.16, 177.94 57.41, 78.2 -96.63, 19.81 285.27, 81.22 -68.88, -9.41 in-in in 9.227 Saltbr-in 2.849 HRD-in -67.2, -51.3 65.19, 13.63 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 161.25 APE9-dihe-na 74.17, 135.57 APE8-dihe-in -52.35, 140.79 APE8-rot-in 295.69 APE67-dihe-in -60.8, -24.95 -48.08, -50.31 APE12-dist-in 13.39 APE11-dist-in 11.433 APE10-dist-in 7.009 APE9-dist-in 3.27 None TPO186 TPO186 XRAY 2.94 0.209 0.245 A 332 315 8 0 0 0 [[19, 315]] 1.0 4imy CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3BLHA 8 325 372.0 No_ligand No_ligand Inactive DFGin 7.105 15.617 BLAminus -129.9, 170.98 63.01, 77.18 -97.75, 18.52 284.97, 81.6 -67.67, -17.09 in-out in 9.598 Saltbr-out 5.608 HRD-in -77.19, -44.8 68.26, 4.38 out-in-in SNCoii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 136.54 APE9-dihe-na 82.17, 131.77 APE8-dihe-in -51.9, 141.65 APE8-rot-in 281.88 APE67-dihe-in -68.04, -21.93 -48.78, -46.05 APE12-dist-in 13.097 APE11-dist-in 9.69 APE10-dist-in 7.388 APE9-dist-in 3.169 None TPO186 TPO186 XRAY 2.48 0.179 0.221 A 331 292 26 0 0 5 [[19, 315]] 1.0 3blh CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3TNIA 7 325 372.0 No_ligand No_ligand Inactive DFGin 6.96 15.518 BLAminus -129.67, 172.05 64.93, 76.48 -99.12, 16.83 286.41, 84.44 -68.12, -14.55 in-out in 9.812 Saltbr-out 6.519 HRD-in -78.02, -45.15 68.07, 5.47 out-in-in SNCoii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 143.65 APE9-dihe-na 85.09, 131.61 APE8-dihe-in -49.91, 142.7 APE8-rot-in 287.18 APE67-dihe-in -68.03, -22.83 -48.7, -45.44 APE12-dist-in 13.389 APE11-dist-in 11.096 APE10-dist-in 7.265 APE9-dist-in 3.245 None TPO186 TPO186 XRAY 3.234 0.166 0.21 A 331 298 21 0 0 6 [[19, 315]] 1.0 3tni CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
7NWKA 7 326 372.0 UT5:401 Type1 Inactive DFGin 7.111 14.991 BLAminus -124.85, 176.65 53.29, 84.25 -99.42, 22.06 284.43, 78.88 -62.72, -24.1 in-in in 9.188 Saltbr-in 3.356 HRD-in -72.75, -46.7 63.63, 12.3 in-in-out SNCiio in-out ActLoopNT-in 2.819 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.99, 150.18 APE9-dihe-na 74.8, 134.0 APE8-dihe-in -57.76, 142.58 APE8-rot-out 9.44 APE67-dihe-in -60.65, -26.29 -46.55, -51.52 APE12-dist-in 12.915 APE11-dist-in 10.299 APE10-dist-in 6.828 APE9-dist-in 3.36 None TPO186 TPO186 XRAY 2.81 0.182 0.205 A 330 298 22 0 0 5 [[19, 315]] 1.0 7nwk CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
3BLRA 7 326 372.0 CPB:940 Type1 Inactive DFGin 6.849 14.983 BLAminus -137.81, 169.59 65.05, 86.98 -102.47, 22.09 282.73, 80.55 -59.33, -27.76 in-in in 9.73 Saltbr-in 3.0 HRD-in -77.6, -52.79 69.15, 9.31 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.25, 157.8 APE9-dihe-na 74.85, 130.66 APE8-dihe-in -57.24, 143.32 APE8-rot-out 21.76 APE67-dihe-in -65.59, -31.38 -41.87, -49.24 APE12-dist-in 13.189 APE11-dist-in 10.838 APE10-dist-in 6.85 APE9-dist-in 3.362 None TPO186 TPO186 XRAY 2.8 0.176 0.228 A 331 301 19 0 0 4 [[19, 315]] 1.0 3blr CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4BCGA 7 327 372.0 T3C:1328 Type1 Inactive DFGin 7.134 15.244 BLAminus -132.48, 173.97 58.32, 78.23 -93.26, 24.05 284.24, 75.68 -68.96, -23.34 in-out in 9.462 Saltbr-out 4.647 HRD-in -78.18, -44.27 68.6, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.1, 147.31 APE9-dihe-na 81.87, 132.15 APE8-dihe-in -51.72, 141.44 APE8-rot-in 291.43 APE67-dihe-in -63.63, -25.74 -50.67, -46.04 APE12-dist-in 13.109 APE11-dist-in 10.231 APE10-dist-in 6.933 APE9-dist-in 3.179 None TPO186 TPO186 XRAY 3.085 0.163 0.197 A 331 313 8 0 0 0 [[19, 315]] 1.0 4bcg CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4BCHA 7 327 372.0 T7Z:1328 Type1 Inactive DFGin 7.022 15.251 BLAminus -131.52, 173.1 62.62, 79.06 -97.34, 18.94 284.72, 72.84 -65.45, -18.12 in-out in 9.564 Saltbr-out 4.337 HRD-in -78.74, -44.37 68.53, 5.43 out-in-in SNCoii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.64, 156.76 APE9-dihe-na 81.03, 133.91 APE8-dihe-in -51.15, 142.4 APE8-rot-in 295.91 APE67-dihe-in -66.84, -22.68 -48.59, -47.41 APE12-dist-in 13.267 APE11-dist-in 10.899 APE10-dist-in 6.912 APE9-dist-in 3.181 None TPO186 TPO186 XRAY 2.958 0.169 0.21 A 331 309 12 0 0 5 [[19, 315]] 1.0 4bch CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4BCIA 5 326 372.0 T3E:1327 Type1 Inactive DFGin 7.099 15.182 BLAminus -131.07, 172.91 63.16, 77.79 -97.71, 24.25 283.9, 77.6 -66.92, -23.58 in-out in 9.472 Saltbr-out 4.196 HRD-in -77.09, -44.37 66.65, 15.51 out-in-in SNCoii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.81, 155.45 APE9-dihe-na 82.12, 132.8 APE8-dihe-in -46.04, 142.98 APE8-rot-in 310.28 APE67-dihe-in -70.86, -24.72 -49.47, -47.11 APE12-dist-in 13.101 APE11-dist-in 11.156 APE10-dist-in 6.828 APE9-dist-in 3.348 None TPO186 TPO186 XRAY 3.1 0.18 0.221 A 331 309 13 0 0 4 [[19, 315]] 1.0 4bci CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
4BCJA 6 326 372.0 T9N:1327 Type1 Inactive DFGin 7.03 15.018 BLAminus -131.0, 170.86 63.37, 81.25 -96.53, 22.01 287.4, 63.38 -57.12, -37.16 in-out in 9.444 Saltbr-out 4.455 HRD-in -79.62, -45.57 66.85, 8.76 out-in-in SNCoii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.55, 158.16 APE9-dihe-na 80.36, 134.65 APE8-dihe-in -47.14, 141.93 APE8-rot-in 299.93 APE67-dihe-in -67.12, -25.13 -50.6, -47.83 APE12-dist-in 13.096 APE11-dist-in 11.108 APE10-dist-in 6.84 APE9-dist-in 3.158 None TPO186 TPO186 XRAY 3.162 0.162 0.207 A 331 310 11 0 0 4 [[19, 315]] 1.0 4bcj CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
8K5RA 5 327 372.0 VQE:401 Type1 Inactive DFGin 7.543 15.463 BLAminus -127.7, -178.83 57.51, 52.57 -82.11, 20.94 280.63, 64.24 -61.34, -43.86 in-out in 9.292 Saltbr-out 3.716 HRD-in -86.18, -55.67 72.35, 16.43 out-in-in SNCoii in-in ActLoopNT-in 2.709 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 166.1 APE9-dihe-na 82.22, 165.84 APE8-dihe-in -71.04, 149.98 APE8-rot-in 312.55 APE67-dihe-in -65.92, -42.72 -67.97, -33.99 APE12-dist-in 12.916 APE11-dist-in 11.442 APE10-dist-in 6.819 APE9-dist-in 3.164 S7D,V8N,K44R,Y138F,K280A,D307E,N311E TPO186 TPO186 XRAY 3.751 0.203 0.245 A 330 306 17 0 0 3 [[19, 315]] 1.0 8k5r CMGC_CDK9_HUMAN CMGC 9.7e-80 273.9 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
6Z45A 5 328 372.0 Q6E:401 Type1 Inactive DFGin 7.317 14.744 BLAminus -124.48, 171.21 57.13, 81.63 -95.68, 19.28 282.63, 77.61 -65.74, -21.16 in-in in 9.092 Saltbr-in 3.441 HRD-in -72.24, -47.68 66.59, 11.95 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.93, 143.26 APE9-dihe-na 76.68, 135.99 APE8-dihe-in -63.34, 144.14 APE8-rot-out 73.55 APE67-dihe-in -62.15, -25.5 -46.95, -49.84 APE12-dist-in 13.079 APE11-dist-in 9.97 APE10-dist-in 7.192 APE9-dist-in 3.326 None TPO186 TPO186 XRAY 3.37 0.174 0.188 A 330 314 10 0 0 4 [[19, 315]] 1.0 6z45 CMGC_CDK9_HUMAN CMGC 1e-79 273.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9

CMGC_CDK9 (Cyclin-dependent kinase 9)

Total number of chains: 35
Active chains: 25
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 35 100.0% AF-P50750-K1A

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CDK9_HUMAN 3BLQA P50750 7 325 372.0 ATP:332 ATPlike Active DFGin 6.983 15.235 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.514 Saltbr-in 3.257 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.028 APE11-dist-in 11.03 APE10-dist-in 6.896 APE9-dist-in 3.154 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331 296 23 0 0 7 [[19, 315]] 1.0 3blq Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4IMYC P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.789 15.123 BLAminus -140.61, 175.84 60.41, 77.79 -97.02, 19.01 284.69, 80.72 -68.98, -8.54 in-in in 9.232 Saltbr-in 2.833 HRD-in -67.68, -50.97 65.16, 13.16 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.81, 161.81 APE9-dihe-na 73.71, 135.92 APE8-dihe-in -53.34, 141.57 APE8-rot-in 294.85 APE67-dihe-in -61.16, -25.06 -47.9, -50.46 APE12-dist-in 13.386 APE11-dist-in 11.431 APE10-dist-in 7.006 APE9-dist-in 3.279 None TPO186 TPO186 XRAY 2.94 0.209 0.245 C 332 311 12 0 0 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4IMYE P50750 8 330 372.0 AMP:401 ATPlike Active DFGin 6.794 15.112 BLAminus -141.41, 175.75 59.75, 77.9 -96.66, 19.65 284.44, 80.03 -69.65, -8.18 in-in in 9.197 Saltbr-in 2.816 HRD-in -68.02, -51.11 68.06, 12.23 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.97, 161.65 APE9-dihe-na 74.14, 135.63 APE8-dihe-in -53.23, 140.74 APE8-rot-in 294.81 APE67-dihe-in -59.86, -25.62 -47.7, -50.88 APE12-dist-in 13.405 APE11-dist-in 11.437 APE10-dist-in 7.01 APE9-dist-in 3.278 None TPO186 TPO186 XRAY 2.94 0.209 0.245 E 332 314 9 0 0 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3MIAA P50750 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.077 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.313 Saltbr-in 2.689 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.258 APE11-dist-in 11.524 APE10-dist-in 6.949 APE9-dist-in 3.523 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351 325 8 0 0 0 [[19, 315]] 1.0 3mia Homo sapiens CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN AF-P50750-K1A P50750 11 323 372.0 No_ligand No_ligand Active DFGin 6.804 15.165 BLAminus -137.37, 173.37 64.39, 60.59 -77.02, 16.85 288.83, 77.77 -62.06, -30.21 in-in in 8.518 Saltbr-in 2.709 HRD-in -74.93, -50.16 64.15, 10.46 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.96, 171.33 APE9-dihe-na 63.33, 135.53 APE8-dihe-in -59.46, 137.0 APE8-rot-in 298.24 APE67-dihe-in -65.46, -22.86 -48.78, -43.32 APE12-dist-in 13.072 APE11-dist-in 11.321 APE10-dist-in 6.647 APE9-dist-in 3.332 None None None AF2 -1.0 1.0 1.0 A 313 313 0 0 0 0 [[19, 315]] 1.0 AF-P50750-K1 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN AF-P50750-K3A P50750 11 323 372.0 No_ligand No_ligand Active DFGin 7.062 14.698 BLAminus -139.94, 174.92 58.53, 50.7 -65.37, 20.59 281.14, 76.16 -63.5, -35.02 in-in in 8.8 Saltbr-in 2.765 HRD-in -75.68, -48.0 63.0, 17.28 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.22, 172.67 APE9-dihe-na 61.33, 130.24 APE8-dihe-in -58.01, 135.54 APE8-rot-in 298.09 APE67-dihe-in -65.99, -22.34 -47.59, -46.0 APE12-dist-in 12.586 APE11-dist-in 10.571 APE10-dist-in 6.205 APE9-dist-in 3.367 None None None AF2 -1.0 1.0 1.0 A 313 313 0 0 0 0 [[19, 315]] 1.0 AF-P50750-K3 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.3e-80 275.4 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4OR5A P50750 8 331 372.0 No_ligand No_ligand Active DFGin 6.943 14.74 BLAminus -124.31, 168.54 69.01, 76.04 -97.31, 28.71 289.03, 30.11 -68.53, -16.51 in-in in 8.982 Saltbr-in 2.762 HRD-in -69.96, -55.39 71.5, 2.58 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 159.55 APE9-dihe-na 76.25, 129.47 APE8-dihe-in -55.54, 147.57 APE8-rot-in 323.78 APE67-dihe-in -55.49, -19.54 -44.65, -58.02 APE12-dist-in 13.144 APE11-dist-in 10.903 APE10-dist-in 6.784 APE9-dist-in 3.212 None TPO186 TPO186 XRAY 2.9 0.225 0.267 A 326 320 4 0 0 0 [[19, 315]] 1.0 4or5 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4OR5F P50750 8 332 372.0 No_ligand No_ligand Active DFGin 6.668 14.98 BLAminus -111.52, -176.73 51.04, 89.5 -102.8, 24.68 281.6, 71.85 -49.29, -46.03 in-in in 9.212 Saltbr-in 2.608 HRD-in -63.05, -54.26 62.81, 29.79 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.12, 165.75 APE9-dihe-na 70.73, 135.03 APE8-dihe-in -51.7, 151.98 APE8-rot-in 310.95 APE67-dihe-in -54.55, -10.13 -58.62, -54.74 APE12-dist-in 12.948 APE11-dist-in 10.819 APE10-dist-in 6.534 APE9-dist-in 3.443 None TPO186 TPO186 XRAY 2.9 0.225 0.267 F 326 325 0 0 0 0 [[19, 315]] 1.0 4or5 Homo sapiens CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 5L1ZA P50750 8 330 372.0 No_ligand No_ligand Active DFGin 7.218 14.599 BLAminus -125.76, -179.91 59.3, 75.76 -100.2, 28.34 287.78, 61.41 -57.18, -56.97 in-in in 8.958 Saltbr-in 2.708 HRD-in -67.89, -46.91 51.73, 43.04 in-in-in SNCiii in-in ActLoopNT-in 2.634 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 164.45 APE9-dihe-na 64.74, 143.58 APE8-dihe-in -57.19, 139.09 APE8-rot-in 301.99 APE67-dihe-in -68.84, -33.17 -48.82, -40.87 APE12-dist-in 12.93 APE11-dist-in 10.747 APE10-dist-in 6.633 APE9-dist-in 3.47 None TPO186 TPO186 XRAY 5.9 0.217 0.313 A 330 311 12 0 0 0 [[19, 315]] 1.0 5l1z Homo sapiens CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 6CYTA P50750 8 330 372.0 No_ligand No_ligand Active DFGin 7.128 14.819 BLAminus -145.42, 171.89 59.31, 72.76 -88.66, 18.9 282.04, 75.69 -58.99, -26.1 in-in in 8.749 Saltbr-in 3.085 HRD-in -78.56, -48.34 62.81, 28.85 in-in-in SNCiii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.32, 170.8 APE9-dihe-na 69.6, 130.71 APE8-dihe-in -52.14, 135.55 APE8-rot-in 303.56 APE67-dihe-in -61.47, -34.74 -50.37, -43.24 APE12-dist-in 13.158 APE11-dist-in 11.341 APE10-dist-in 6.765 APE9-dist-in 3.758 None TPO186 TPO186 XRAY 3.5 0.251 0.283 A 332 319 4 0 0 0 [[19, 315]] 1.0 6cyt Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3MI9A P50750 8 344 372.0 No_ligand No_ligand Active DFGin 7.217 15.083 BLAminus -131.5, 175.99 56.36, 81.19 -96.49, 22.86 283.32, 81.7 -61.79, -15.23 in-in in 9.37 Saltbr-in 2.661 HRD-in -69.68, -51.06 64.68, 15.58 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.92, 157.04 APE9-dihe-na 77.38, 136.99 APE8-dihe-in -56.37, 139.72 APE8-rot-in 276.81 APE67-dihe-in -58.41, -18.53 -45.4, -54.86 APE12-dist-in 13.481 APE11-dist-in 11.309 APE10-dist-in 7.271 APE9-dist-in 3.269 None TPO186 TPO186 XRAY 2.1 0.219 0.264 A 351 329 8 0 0 0 [[19, 315]] 1.0 3mi9 Homo sapiens CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4EC8A P50750 6 338 372.0 No_ligand No_ligand Active DFGin 7.021 14.71 BLAminus -136.31, 174.5 61.51, 81.72 -97.53, 24.16 282.28, 73.66 -54.62, -38.88 in-in in 9.043 Saltbr-in 2.941 HRD-in -86.88, -43.45 62.41, 27.26 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.08, 171.7 APE9-dihe-na 55.16, 133.32 APE8-dihe-in -40.35, 153.59 APE8-rot-in 304.69 APE67-dihe-in -58.26, -42.11 -57.08, -55.81 APE12-dist-in 13.106 APE11-dist-in 11.158 APE10-dist-in 6.718 APE9-dist-in 3.298 None TPO186 TPO186 XRAY 3.6 0.194 0.23 A 373 326 7 0 0 0 [[19, 315]] 1.0 4ec8 Homo sapiens CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4EC9A P50750 7 327 372.0 No_ligand No_ligand Active DFGin 6.963 15.031 BLAminus -130.28, 170.97 63.86, 78.14 -96.65, 19.21 284.99, 81.64 -66.97, -16.11 in-in in 9.502 Saltbr-in 3.167 HRD-in -77.71, -44.73 68.48, 6.05 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -124.99, 139.69 APE9-dihe-na 84.51, 133.17 APE8-dihe-in -49.64, 141.35 APE8-rot-in 313.22 APE67-dihe-in -69.04, -23.15 -49.34, -46.9 APE12-dist-in 13.439 APE11-dist-in 11.28 APE10-dist-in 7.175 APE9-dist-in 2.912 None TPO186 TPO186 XRAY 3.21 0.203 0.233 A 373 307 14 0 0 0 [[19, 315]] 1.0 4ec9 Homo sapiens CMGC_CDK9_HUMAN CMGC 6.3e-80 274.7 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4BCFA P50750 6 326 372.0 T6Q:1327 Type1 Active DFGin 7.035 15.006 BLAminus -130.89, 175.85 58.26, 78.19 -93.84, 20.92 284.01, 74.28 -69.0, -18.91 in-in in 9.385 Saltbr-in 3.454 HRD-in -78.09, -44.7 68.67, 6.76 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.92, 149.94 APE9-dihe-na 81.04, 132.5 APE8-dihe-in -49.66, 140.73 APE8-rot-in 291.42 APE67-dihe-in -67.27, -22.18 -50.7, -44.79 APE12-dist-in 13.104 APE11-dist-in 10.304 APE10-dist-in 6.907 APE9-dist-in 3.128 None TPO186 TPO186 XRAY 3.011 0.169 0.224 A 331 308 13 0 0 5 [[19, 315]] 1.0 4bcf Homo sapiens CMGC_CDK9_HUMAN CMGC 3.7e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 8I0LA P50750 6 326 372.0 NJ6:401 Type1 Active DFGin 7.293 15.855 BLAminus -130.69, 179.52 57.03, 69.82 -94.01, 27.86 282.24, 73.6 -69.08, -49.61 in-in in 9.573 Saltbr-in 3.235 HRD-in -83.43, -47.61 60.01, 23.96 in-in-in SNCiii in-in ActLoopNT-in 2.759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.64, 163.64 APE9-dihe-na 68.82, 138.39 APE8-dihe-in -61.18, 156.44 APE8-rot-in 324.35 APE67-dihe-in -70.36, -22.43 -60.05, -41.69 APE12-dist-in 12.809 APE11-dist-in 10.347 APE10-dist-in 6.433 APE9-dist-in 3.549 None TPO186 TPO186 XRAY 3.6 0.235 0.257 A 332 308 13 0 0 5 [[19, 315]] 1.0 8i0l Homo sapiens CMGC_CDK9_HUMAN CMGC 3.8e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 6GZHA P50750 8 326 372.0 LCI:2001 Type1 Active DFGin 6.962 15.276 BLAminus -143.64, 171.3 50.95, 83.68 -93.37, 33.37 284.73, 74.17 -64.71, -41.34 in-in in 9.645 Saltbr-in 2.886 HRD-in -65.68, -54.2 64.63, 22.42 in-in-in SNCiii in-in ActLoopNT-in 2.772 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.77, 163.06 APE9-dihe-na 70.11, 142.16 APE8-dihe-in -60.75, 137.92 APE8-rot-in 300.9 APE67-dihe-in -63.71, -23.63 -48.56, -44.41 APE12-dist-in 12.829 APE11-dist-in 10.306 APE10-dist-in 6.58 APE9-dist-in 3.427 None TPO186 TPO186 XRAY 3.17 0.175 0.257 A 326 310 9 0 0 3 [[19, 315]] 1.0 6gzh Homo sapiens CMGC_CDK9_HUMAN CMGC 3.9e-80 275.2 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3LQ5A P50750 6 327 372.0 SLQ:331 Type1 Active DFGin 7.077 14.862 BLAminus -142.24, 175.94 56.62, 82.08 -95.24, 28.75 286.71, 83.42 -69.95, -28.82 in-in in 9.106 Saltbr-in 3.55 HRD-in -75.08, -43.56 66.05, 12.53 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.5, 158.49 APE9-dihe-na 76.36, 121.96 APE8-dihe-in -35.3, 136.84 APE8-rot-in 307.0 APE67-dihe-in -57.48, -14.79 -49.62, -56.61 APE12-dist-in 13.159 APE11-dist-in 10.52 APE10-dist-in 6.791 APE9-dist-in 3.532 None TPO186 TPO186 XRAY 3.0 0.165 0.215 A 331 308 14 0 0 4 [[19, 315]] 1.0 3lq5 Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3MY1A P50750 6 327 372.0 RFZ:336 Type1 Active DFGin 6.92 14.737 BLAminus -138.6, -178.76 55.85, 82.27 -96.58, 26.19 286.18, 71.12 -65.01, -22.99 in-in in 9.174 Saltbr-in 3.024 HRD-in -74.76, -49.19 65.23, 25.42 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.34, 163.18 APE9-dihe-na 70.44, 131.12 APE8-dihe-in -41.78, 152.21 APE8-rot-in 296.57 APE67-dihe-in -62.52, -36.66 -60.91, -51.23 APE12-dist-in 13.127 APE11-dist-in 11.22 APE10-dist-in 6.853 APE9-dist-in 3.38 None TPO186 TPO186 XRAY 2.8 0.175 0.214 A 331 315 7 0 0 0 [[19, 315]] 1.0 3my1 Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3TN8A P50750 8 325 372.0 F18:332 Type1 Active DFGin 6.928 14.758 BLAminus -143.85, 178.49 57.5, 79.87 -95.98, 37.06 283.24, 76.06 -66.12, -47.35 in-in in 8.875 Saltbr-in 3.079 HRD-in -75.16, -50.1 67.86, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.743 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.91, 161.16 APE9-dihe-na 76.41, 125.51 APE8-dihe-in -47.81, 145.62 APE8-rot-in 301.4 APE67-dihe-in -65.71, -32.31 -55.05, -44.31 APE12-dist-in 12.863 APE11-dist-in 10.197 APE10-dist-in 6.704 APE9-dist-in 3.197 None TPO186 TPO186 XRAY 2.95 0.179 0.221 A 331 305 13 0 0 4 [[19, 315]] 1.0 3tn8 Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3TNHA P50750 8 328 372.0 F18:400 Type1 Active DFGin 6.895 14.863 BLAminus -133.46, 172.31 64.77, 76.91 -97.39, 20.03 283.08, 80.82 -68.17, -17.73 in-in in 9.065 Saltbr-in 3.343 HRD-in -75.15, -45.06 69.35, 5.53 in-in-in SNCiii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.95, 145.17 APE9-dihe-na 82.57, 129.21 APE8-dihe-in -52.21, 142.64 APE8-rot-in 282.87 APE67-dihe-in -68.26, -22.31 -48.58, -47.58 APE12-dist-in 12.85 APE11-dist-in 9.703 APE10-dist-in 6.867 APE9-dist-in 3.198 None TPO186 TPO186 XRAY 3.202 0.179 0.226 A 331 289 32 0 0 7 [[19, 315]] 1.0 3tnh Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4OGRA P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 6.959 14.852 BLAminus -145.48, 171.71 58.99, 73.11 -88.05, 19.07 282.19, 75.89 -59.04, -25.77 in-in in 8.622 Saltbr-in 3.202 HRD-in -78.29, -48.1 62.83, 28.93 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.59, 171.14 APE9-dihe-na 70.34, 130.75 APE8-dihe-in -51.49, 135.3 APE8-rot-in 303.62 APE67-dihe-in -61.39, -34.94 -50.28, -42.94 APE12-dist-in 13.245 APE11-dist-in 11.482 APE10-dist-in 6.706 APE9-dist-in 3.205 None TPO186 TPO186 XRAY 3.0 0.206 0.232 A 332 315 8 0 0 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4OGRE P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.086 14.749 BLAminus -145.95, 172.29 59.47, 72.14 -89.89, 19.36 283.65, 75.49 -58.97, -26.2 in-in in 8.801 Saltbr-in 2.931 HRD-in -77.91, -48.96 62.4, 28.78 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.99, 169.74 APE9-dihe-na 65.95, 134.0 APE8-dihe-in -52.43, 138.08 APE8-rot-in 303.65 APE67-dihe-in -62.11, -36.08 -50.82, -43.72 APE12-dist-in 13.214 APE11-dist-in 11.177 APE10-dist-in 6.799 APE9-dist-in 3.429 None TPO186 TPO186 XRAY 3.0 0.206 0.232 E 332 311 12 0 0 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4OGRI P50750 8 330 372.0 ADN:60401 Type1 Active DFGin 7.02 14.857 BLAminus -146.32, 171.3 58.62, 73.81 -88.0, 20.33 283.45, 75.93 -58.21, -25.18 in-in in 8.754 Saltbr-in 3.252 HRD-in -77.88, -47.68 62.44, 29.24 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.71, 169.37 APE9-dihe-na 67.96, 131.32 APE8-dihe-in -52.01, 135.85 APE8-rot-in 303.33 APE67-dihe-in -60.26, -34.97 -51.39, -42.17 APE12-dist-in 13.226 APE11-dist-in 11.036 APE10-dist-in 6.524 APE9-dist-in 3.127 None TPO186 TPO186 XRAY 3.0 0.206 0.232 I 332 319 4 0 0 0 [[19, 315]] 1.0 4ogr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 6W9EA P50750 7 326 372.0 TO7:401,TO7:402,TOJ:403,TOJ:404 Type1,Type1,Type1,Type1 Active DFGin 7.001 15.083 BLAminus -134.21, 172.07 61.13, 81.04 -94.79, 28.67 292.71, 81.0 -65.23, -42.38 in-in in 9.226 Saltbr-in 3.047 HRD-in -77.57, -45.55 60.07, 27.0 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.35, 150.83 APE9-dihe-na 76.33, 139.44 APE8-dihe-in -54.19, 159.88 APE8-rot-in 315.27 APE67-dihe-in -69.62, -18.61 -64.18, -47.28 APE12-dist-in 12.768 APE11-dist-in 10.465 APE10-dist-in 6.775 APE9-dist-in 3.411 None TPO186,SEP306 TPO186,SEP306 XRAY 3.1 0.175 0.221 A 330 311 9 0 0 4 [[19, 315]] 1.0 6w9e Homo sapiens CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4IMYA P50750 8 330 372.0 AMP:401 Type1.5_Back Active DFGin 6.761 15.126 BLAminus -140.16, 177.94 57.41, 78.2 -96.63, 19.81 285.27, 81.22 -68.88, -9.41 in-in in 9.227 Saltbr-in 2.849 HRD-in -67.2, -51.3 65.19, 13.63 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.99, 161.25 APE9-dihe-na 74.17, 135.57 APE8-dihe-in -52.35, 140.79 APE8-rot-in 295.69 APE67-dihe-in -60.8, -24.95 -48.08, -50.31 APE12-dist-in 13.39 APE11-dist-in 11.433 APE10-dist-in 7.009 APE9-dist-in 3.27 None TPO186 TPO186 XRAY 2.94 0.209 0.245 A 332 315 8 0 0 0 [[19, 315]] 1.0 4imy Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3BLHA P50750 8 325 372.0 No_ligand No_ligand Inactive DFGin 7.105 15.617 BLAminus -129.9, 170.98 63.01, 77.18 -97.75, 18.52 284.97, 81.6 -67.67, -17.09 in-out in 9.598 Saltbr-out 5.608 HRD-in -77.19, -44.8 68.26, 4.38 out-in-in SNCoii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 136.54 APE9-dihe-na 82.17, 131.77 APE8-dihe-in -51.9, 141.65 APE8-rot-in 281.88 APE67-dihe-in -68.04, -21.93 -48.78, -46.05 APE12-dist-in 13.097 APE11-dist-in 9.69 APE10-dist-in 7.388 APE9-dist-in 3.169 None TPO186 TPO186 XRAY 2.48 0.179 0.221 A 331 292 26 0 0 5 [[19, 315]] 1.0 3blh Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3TNIA P50750 7 325 372.0 No_ligand No_ligand Inactive DFGin 6.96 15.518 BLAminus -129.67, 172.05 64.93, 76.48 -99.12, 16.83 286.41, 84.44 -68.12, -14.55 in-out in 9.812 Saltbr-out 6.519 HRD-in -78.02, -45.15 68.07, 5.47 out-in-in SNCoii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 143.65 APE9-dihe-na 85.09, 131.61 APE8-dihe-in -49.91, 142.7 APE8-rot-in 287.18 APE67-dihe-in -68.03, -22.83 -48.7, -45.44 APE12-dist-in 13.389 APE11-dist-in 11.096 APE10-dist-in 7.265 APE9-dist-in 3.245 None TPO186 TPO186 XRAY 3.234 0.166 0.21 A 331 298 21 0 0 6 [[19, 315]] 1.0 3tni Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 7NWKA P50750 7 326 372.0 UT5:401 Type1 Inactive DFGin 7.111 14.991 BLAminus -124.85, 176.65 53.29, 84.25 -99.42, 22.06 284.43, 78.88 -62.72, -24.1 in-in in 9.188 Saltbr-in 3.356 HRD-in -72.75, -46.7 63.63, 12.3 in-in-out SNCiio in-out ActLoopNT-in 2.819 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -125.99, 150.18 APE9-dihe-na 74.8, 134.0 APE8-dihe-in -57.76, 142.58 APE8-rot-out 9.44 APE67-dihe-in -60.65, -26.29 -46.55, -51.52 APE12-dist-in 12.915 APE11-dist-in 10.299 APE10-dist-in 6.828 APE9-dist-in 3.36 None TPO186 TPO186 XRAY 2.81 0.182 0.205 A 330 298 22 0 0 5 [[19, 315]] 1.0 7nwk Homo sapiens CMGC_CDK9_HUMAN CMGC 4e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 3BLRA P50750 7 326 372.0 CPB:940 Type1 Inactive DFGin 6.849 14.983 BLAminus -137.81, 169.59 65.05, 86.98 -102.47, 22.09 282.73, 80.55 -59.33, -27.76 in-in in 9.73 Saltbr-in 3.0 HRD-in -77.6, -52.79 69.15, 9.31 in-in-out SNCiio in-out ActLoopNT-in 2.838 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.25, 157.8 APE9-dihe-na 74.85, 130.66 APE8-dihe-in -57.24, 143.32 APE8-rot-out 21.76 APE67-dihe-in -65.59, -31.38 -41.87, -49.24 APE12-dist-in 13.189 APE11-dist-in 10.838 APE10-dist-in 6.85 APE9-dist-in 3.362 None TPO186 TPO186 XRAY 2.8 0.176 0.228 A 331 301 19 0 0 4 [[19, 315]] 1.0 3blr Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4BCGA P50750 7 327 372.0 T3C:1328 Type1 Inactive DFGin 7.134 15.244 BLAminus -132.48, 173.97 58.32, 78.23 -93.26, 24.05 284.24, 75.68 -68.96, -23.34 in-out in 9.462 Saltbr-out 4.647 HRD-in -78.18, -44.27 68.6, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.1, 147.31 APE9-dihe-na 81.87, 132.15 APE8-dihe-in -51.72, 141.44 APE8-rot-in 291.43 APE67-dihe-in -63.63, -25.74 -50.67, -46.04 APE12-dist-in 13.109 APE11-dist-in 10.231 APE10-dist-in 6.933 APE9-dist-in 3.179 None TPO186 TPO186 XRAY 3.085 0.163 0.197 A 331 313 8 0 0 0 [[19, 315]] 1.0 4bcg Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4BCHA P50750 7 327 372.0 T7Z:1328 Type1 Inactive DFGin 7.022 15.251 BLAminus -131.52, 173.1 62.62, 79.06 -97.34, 18.94 284.72, 72.84 -65.45, -18.12 in-out in 9.564 Saltbr-out 4.337 HRD-in -78.74, -44.37 68.53, 5.43 out-in-in SNCoii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.64, 156.76 APE9-dihe-na 81.03, 133.91 APE8-dihe-in -51.15, 142.4 APE8-rot-in 295.91 APE67-dihe-in -66.84, -22.68 -48.59, -47.41 APE12-dist-in 13.267 APE11-dist-in 10.899 APE10-dist-in 6.912 APE9-dist-in 3.181 None TPO186 TPO186 XRAY 2.958 0.169 0.21 A 331 309 12 0 0 5 [[19, 315]] 1.0 4bch Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4BCIA P50750 5 326 372.0 T3E:1327 Type1 Inactive DFGin 7.099 15.182 BLAminus -131.07, 172.91 63.16, 77.79 -97.71, 24.25 283.9, 77.6 -66.92, -23.58 in-out in 9.472 Saltbr-out 4.196 HRD-in -77.09, -44.37 66.65, 15.51 out-in-in SNCoii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.81, 155.45 APE9-dihe-na 82.12, 132.8 APE8-dihe-in -46.04, 142.98 APE8-rot-in 310.28 APE67-dihe-in -70.86, -24.72 -49.47, -47.11 APE12-dist-in 13.101 APE11-dist-in 11.156 APE10-dist-in 6.828 APE9-dist-in 3.348 None TPO186 TPO186 XRAY 3.1 0.18 0.221 A 331 309 13 0 0 4 [[19, 315]] 1.0 4bci Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 4BCJA P50750 6 326 372.0 T9N:1327 Type1 Inactive DFGin 7.03 15.018 BLAminus -131.0, 170.86 63.37, 81.25 -96.53, 22.01 287.4, 63.38 -57.12, -37.16 in-out in 9.444 Saltbr-out 4.455 HRD-in -79.62, -45.57 66.85, 8.76 out-in-in SNCoii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.55, 158.16 APE9-dihe-na 80.36, 134.65 APE8-dihe-in -47.14, 141.93 APE8-rot-in 299.93 APE67-dihe-in -67.12, -25.13 -50.6, -47.83 APE12-dist-in 13.096 APE11-dist-in 11.108 APE10-dist-in 6.84 APE9-dist-in 3.158 None TPO186 TPO186 XRAY 3.162 0.162 0.207 A 331 310 11 0 0 4 [[19, 315]] 1.0 4bcj Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 8K5RA P50750 5 327 372.0 VQE:401 Type1 Inactive DFGin 7.543 15.463 BLAminus -127.7, -178.83 57.51, 52.57 -82.11, 20.94 280.63, 64.24 -61.34, -43.86 in-out in 9.292 Saltbr-out 3.716 HRD-in -86.18, -55.67 72.35, 16.43 out-in-in SNCoii in-in ActLoopNT-in 2.709 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.28, 166.1 APE9-dihe-na 82.22, 165.84 APE8-dihe-in -71.04, 149.98 APE8-rot-in 312.55 APE67-dihe-in -65.92, -42.72 -67.97, -33.99 APE12-dist-in 12.916 APE11-dist-in 11.442 APE10-dist-in 6.819 APE9-dist-in 3.164 S7D,V8N,K44R,Y138F,K280A,D307E,N311E TPO186 TPO186 XRAY 3.751 0.203 0.245 A 330 306 17 0 0 3 [[19, 315]] 1.0 8k5r Homo sapiens CMGC_CDK9_HUMAN CMGC 9.7e-80 273.9 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CDK9_HUMAN 6Z45A P50750 5 328 372.0 Q6E:401 Type1 Inactive DFGin 7.317 14.744 BLAminus -124.48, 171.21 57.13, 81.63 -95.68, 19.28 282.63, 77.61 -65.74, -21.16 in-in in 9.092 Saltbr-in 3.441 HRD-in -72.24, -47.68 66.59, 11.95 in-in-out SNCiio in-out ActLoopNT-in 2.824 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.93, 143.26 APE9-dihe-na 76.68, 135.99 APE8-dihe-in -63.34, 144.14 APE8-rot-out 73.55 APE67-dihe-in -62.15, -25.5 -46.95, -49.84 APE12-dist-in 13.079 APE11-dist-in 9.97 APE10-dist-in 7.192 APE9-dist-in 3.326 None TPO186 TPO186 XRAY 3.37 0.174 0.188 A 330 314 10 0 0 4 [[19, 315]] 1.0 6z45 Homo sapiens CMGC_CDK9_HUMAN CMGC 1e-79 273.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9

CMGC_CDK9 (Cyclin-dependent kinase 9)

Total number of chains: 0
Active chains: 0
Family: CMGC
Spatial label Dihedral label Number of Chains Percent Representative

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name