TYR_ABL1 (Tyrosine-protein kinase ABL1)

Total number of chains: 96
Active chains: 11
Family: TYR
Uniprot: ABL1_HUMAN
Kinase Domain Residues: 242 - 495
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 29 30.2% 3QRJB
DFGinter None 26 27.1% 2G2HA
DFGin BLAminus 16 16.7% AF-P00519-K1A
DFGout None 15 15.6% 2HZIA
DFGin BLBplus 6 6.2% 2G1TA
DFGinter BABtrans 3 3.1% 7W7XA
None None 1 1.0% 4WA9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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PDB First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
2HZ4C 234 500 1130.0 4ST:501 Allosteric Active DFGin 7.109 13.517 BLAminus -106.9, 179.4 68.82, 76.0 -90.83, 7.94 295.39, 93.15 -43.83, -23.1 in-in in 7.878 Saltbr-in 2.737 HRD-in -90.54, -43.68 68.76, 3.22 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.98, 153.91 APE9-dihe-in -143.05, 161.74 APE8-dihe-in -62.63, 109.18 APE8-rot-na 10.02 APE67-dihe-in -54.86, -29.12 -56.69, -54.75 APE12-dist-na 14.951 APE11-dist-na 10.157 APE10-dist-na 13.134 APE9-dist-in 7.41 None None None XRAY 2.8 0.22 0.285 C 273 259 8 0 0 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7N9GB 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.754 13.445 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.807 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.041 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.951 APE11-dist-na 10.121 APE10-dist-na 12.279 APE9-dist-in 7.137 None None None XRAY 2.2 0.219 0.251 B 271 264 2 0 0 0 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
AF-P00519-K1A 234 503 1130.0 No_ligand No_ligand Active DFGin 6.679 13.681 BLAminus -121.82, -148.36 27.66, 69.52 -83.21, 16.04 300.66, 100.42 -58.22, -38.59 in-in in 7.98 Saltbr-in 2.679 HRD-in -80.76, -46.58 69.6, -13.75 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.75, 141.7 APE9-dihe-in -129.36, 153.57 APE8-dihe-in -68.2, 94.98 APE8-rot-na 29.24 APE67-dihe-in -68.16, -17.51 -48.71, -43.64 APE12-dist-na 14.792 APE11-dist-na 9.969 APE10-dist-na 12.408 APE9-dist-in 6.952 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[242, 495]] 1.0 AF-P00519-K1 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
AF-P00519-K3A 234 503 1130.0 No_ligand No_ligand Active DFGin 6.361 13.579 BLAminus -138.26, -173.5 60.01, 57.15 -76.49, 13.27 303.75, 99.33 -58.39, -34.06 in-in in 7.815 Saltbr-in 2.755 HRD-in -85.57, -49.18 70.08, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.76, 136.34 APE9-dihe-in -128.76, 153.96 APE8-dihe-in -76.2, 91.75 APE8-rot-na 33.55 APE67-dihe-in -64.39, -24.25 -44.48, -44.47 APE12-dist-na 14.635 APE11-dist-na 9.825 APE10-dist-na 11.728 APE9-dist-in 6.601 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[242, 495]] 1.0 AF-P00519-K3 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4TWPA 233 503 1130.0 AXI:601 Type1 Active DFGin 6.826 13.373 BLAminus -126.1, -169.4 57.38, 73.68 -93.34, 9.79 307.92, 111.58 -48.96, -36.81 in-in in 7.981 Saltbr-in 2.446 HRD-in -95.85, -58.6 83.7, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.5, 146.64 APE9-dihe-in -124.84, 163.92 APE8-dihe-in -72.62, 90.26 APE8-rot-na 28.03 APE67-dihe-in -71.19, -17.43 -45.75, -44.99 APE12-dist-na 14.989 APE11-dist-na 10.195 APE10-dist-na 13.212 APE9-dist-in 7.168 T315I None None XRAY 2.4 0.213 0.241 A 271 266 5 0 0 0 [[242, 495]] 1.0 4twp TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4TWPB 233 503 1130.0 AXI:601 Type1 Active DFGin 6.728 13.117 BLAminus -138.14, -168.47 59.67, 66.52 -88.52, 8.05 307.93, 102.65 -49.29, -39.91 in-in in 7.772 Saltbr-in 2.648 HRD-in -82.31, -50.76 78.18, -18.83 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.57, 120.03 APE9-dihe-in -116.59, 156.81 APE8-dihe-in -66.81, 119.12 APE8-rot-na 347.15 APE67-dihe-in -70.99, -21.45 -67.92, -38.41 APE12-dist-na 15.208 APE11-dist-na 10.654 APE10-dist-na 13.036 APE9-dist-in 6.848 T315I None None XRAY 2.4 0.213 0.241 B 271 271 0 0 0 0 [[242, 495]] 1.0 4twp TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2V7AA 233 503 1130.0 627:1504 Type1 Active DFGin 6.894 14.16 BLAminus -145.06, -170.76 64.01, 66.73 -92.57, 17.46 295.88, 104.37 -56.64, -27.12 in-in in 7.782 Saltbr-in 2.519 HRD-in -93.72, -56.9 83.27, 8.16 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.69, 132.9 APE9-dihe-in -115.95, 155.97 APE8-dihe-in -67.28, 120.19 APE8-rot-na 16.95 APE67-dihe-in -81.75, -3.2 -58.95, -43.12 APE12-dist-na 14.866 APE11-dist-na 10.223 APE10-dist-na 13.016 APE9-dist-in 6.841 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 A 286 271 0 0 0 0 [[242, 495]] 1.0 2v7a TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2V7AB 234 503 1130.0 627:1504 Type1 Active DFGin 6.904 13.955 BLAminus -120.25, -166.43 59.68, 67.6 -85.2, 11.1 297.73, 106.5 -52.29, -48.72 in-in in 7.535 Saltbr-in 2.696 HRD-in -95.53, -42.9 77.78, -18.98 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.95, 149.39 APE9-dihe-in -131.37, 144.36 APE8-dihe-in -64.58, 88.08 APE8-rot-na 22.1 APE67-dihe-in -78.01, -10.87 -49.77, -37.43 APE12-dist-na 14.954 APE11-dist-na 10.309 APE10-dist-na 13.12 APE9-dist-in 7.359 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 B 286 270 0 0 0 0 [[242, 495]] 1.0 2v7a TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HZ4B 233 498 1130.0 4ST:501 Type1 Active DFGin 6.781 12.906 BLAminus -136.29, 178.03 62.62, 92.29 -99.12, 17.06 306.64, 102.22 -49.71, -38.7 in-in in 8.114 Saltbr-in 2.713 HRD-in -96.51, -47.12 66.31, -5.28 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.77, 139.94 APE9-dihe-in -124.12, 153.4 APE8-dihe-in -60.98, 117.48 APE8-rot-na 25.18 APE67-dihe-in -77.16, -10.29 -56.55, -40.66 APE12-dist-na 14.733 APE11-dist-na 10.004 APE10-dist-na 12.996 APE9-dist-in 7.129 None None None XRAY 2.8 0.22 0.285 B 273 261 5 0 0 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2F4JA 227 513 1130.0 VX6:514 Type1 Active DFGin 6.831 13.63 BLAminus -139.09, -163.86 46.92, 83.86 -101.63, 25.32 309.5, 96.14 -54.55, -28.15 in-in in 8.08 Saltbr-in 2.583 HRD-in -88.91, -46.94 72.68, 7.25 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.54, 142.96 APE9-dihe-in -128.46, 161.87 APE8-dihe-in -67.39, 90.98 APE8-rot-na 332.91 APE67-dihe-in -62.36, -25.51 -37.57, -50.75 APE12-dist-na 15.236 APE11-dist-na 10.443 APE10-dist-na 13.086 APE9-dist-in 7.322 H396P None None XRAY 1.91 0.207 0.239 A 287 287 0 0 0 0 [[242, 495]] 1.0 2f4j TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2GQGB 229 499 1130.0 1N1:60502 Type1.5_Back Active DFGin 6.725 13.407 BLAminus -132.96, -163.46 57.81, 75.2 -98.78, 6.6 302.62, 104.4 -52.45, -32.74 in-in in 8.034 Saltbr-in 2.899 HRD-in -101.91, -48.31 65.85, 10.15 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.98, 171.69 APE9-dihe-in -137.71, 138.65 APE8-dihe-in -58.61, 114.78 APE8-rot-na 30.65 APE67-dihe-in -71.5, -8.45 -53.53, -44.9 APE12-dist-na 11.258 APE11-dist-na 7.468 APE10-dist-na 11.641 APE9-dist-in 6.276 None PTR393 PTR393 XRAY 2.4 0.208 0.273 B 278 271 0 0 0 0 [[242, 495]] 1.0 2gqg TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G2IA 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.631 13.433 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.005 Saltbr-in 3.247 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.904 APE11-dist-na 10.573 APE10-dist-na 12.836 APE9-dist-in 7.31 H396P None None XRAY 3.12 0.251 0.308 A 287 271 3 0 0 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G2IB 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.623 13.745 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.795 Saltbr-in 2.872 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.404 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.975 APE11-dist-na 10.34 APE10-dist-na 12.829 APE9-dist-in 7.625 H396P None None XRAY 3.12 0.251 0.308 B 287 265 4 0 0 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HZ4A 234 500 1130.0 4ST:501 Allosteric Inactive DFGin 6.899 13.314 BLAminus -141.07, -179.05 61.44, 74.68 -93.23, 11.06 298.48, 103.02 -47.37, -45.58 in-out in 8.043 Saltbr-out 4.199 HRD-in -73.48, -44.6 66.11, 2.51 out-in-in SNCoii in-in ActLoopNT-in 3.136 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.55, 127.23 APE9-dihe-in -112.0, 154.72 APE8-dihe-in -73.75, 92.13 APE8-rot-na 28.06 APE67-dihe-in -62.73, -9.15 -43.63, -56.72 APE12-dist-na 15.433 APE11-dist-na 10.608 APE10-dist-na 12.472 APE9-dist-in 7.423 None None None XRAY 2.8 0.22 0.285 A 273 262 5 0 0 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6XR6A 229 515 1130.0 No_ligand No_ligand Inactive DFGin 6.202 12.576 BLAminus -139.61, -169.12 45.42, 85.51 -100.09, 27.27 299.51, 89.83 -59.45, -29.58 in-in in 8.365 Saltbr-in 2.779 HRD-in -105.48, -39.35 69.66, 6.23 in-out-in SNCioi out-in ActLoopNT-out 3.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.77, 106.46 APE9-dihe-in -100.35, 127.3 APE8-dihe-in -74.27, 111.44 APE8-rot-na 29.98 APE67-dihe-in -67.49, -13.13 -54.87, -37.15 APE12-dist-na 11.902 APE11-dist-na 11.413 APE10-dist-na 7.638 APE9-dist-in 4.653 None None None NMR 999.0 999.0 999.0 A 287 287 0 0 0 0 [[242, 495]] 1.0 6xr6 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2GQGA 229 500 1130.0 1N1:60501 Type1 Inactive DFGin 6.637 14.039 BLAminus -125.87, -162.48 50.1, 80.24 -101.91, 13.59 304.08, 105.04 -55.58, -28.07 in-in in 8.206 Saltbr-in 3.337 HRD-in -94.17, -46.19 69.1, 8.59 in-in-out SNCiio in-out ActLoopNT-in 3.089 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.45, -178.77 APE9-dihe-in -144.75, 146.99 APE8-dihe-in -51.41, 101.22 APE8-rot-na 30.18 APE67-dihe-in -72.33, -8.18 -47.68, -48.27 APE12-dist-na 13.807 APE11-dist-na 10.155 APE10-dist-na 13.162 APE9-dist-in 7.017 None PTR393 PTR393 XRAY 2.4 0.208 0.273 A 278 272 0 0 0 0 [[242, 495]] 1.0 2gqg TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8SSNB 64 506 1130.0 AY7:60601,SKI:60602 Allosteric,Type1 Inactive DFGin 4.807 13.65 BLBplus -122.3, -177.61 58.55, 39.13 -103.24, 130.77 75.83, 117.96 81.37, 999.0 out-out out 13.62 Saltbr-out 14.026 HRD-in -82.83, -50.46 68.17, -10.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 11.09 APE8-rot-na 31.53 APE67-dihe-in -79.53, -5.66 -99.34, -42.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 B 448 385 51 0 0 18 [[242, 495]] 1.0 8ssn TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8SSNA 64 507 1130.0 AY7:60601,SKI:60602 Allosteric,Type1.5_Back Inactive DFGin 5.429 12.696 BLBplus -123.62, -174.23 61.42, 33.23 -93.01, 133.21 53.71, 95.25 73.81, 0.97 out-out out 14.038 Saltbr-out 13.989 HRD-in -74.8, -57.17 85.55, -3.37 out-out-none SNCoon out-none ActLoopNT-out 10.264 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.56 APE8-rot-na 17.66 APE67-dihe-in -74.03, -24.85 -108.88, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 A 448 419 16 0 0 11 [[242, 495]] 1.0 8ssn TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G1TA 232 502 1130.0 No_ligand No_ligand Inactive DFGin 5.489 13.359 BLBplus -129.52, 174.85 49.7, 38.76 -72.97, 132.27 38.5, 86.98 68.27, 5.02 out-out out 14.394 Saltbr-out 14.447 HRD-in -72.65, -55.09 74.07, -6.35 out-out-out SNCooo out-out ActLoopNT-out 7.333 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -93.21, 127.41 APE9-dihe-in -142.61, 161.69 APE8-dihe-in -90.21, 73.8 APE8-rot-na 25.96 APE67-dihe-in -72.87, -5.55 -36.53, -50.03 APE12-dist-na 21.695 APE11-dist-na 17.127 APE10-dist-na 15.501 APE9-dist-out 8.503 None None None XRAY 1.8 0.221 0.244 A 287 271 0 0 0 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G1TB 230 502 1130.0 No_ligand No_ligand Inactive DFGin 5.613 13.461 BLBplus -123.19, 174.0 52.07, 35.11 -71.07, 127.0 40.58, 89.58 70.82, 9.16 out-out out 14.502 Saltbr-out 14.408 HRD-in -70.85, -56.38 81.24, -19.54 out-out-out SNCooo out-out ActLoopNT-out 7.337 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.93, 136.77 APE9-dihe-in -145.05, 161.95 APE8-dihe-in -89.74, 74.17 APE8-rot-na 33.06 APE67-dihe-in -70.55, -3.76 -28.93, -56.54 APE12-dist-na 21.369 APE11-dist-na 16.867 APE10-dist-na 15.526 APE9-dist-out 8.271 None None None XRAY 1.8 0.221 0.244 B 287 273 0 0 0 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G1TC 232 507 1130.0 No_ligand No_ligand Inactive DFGin 5.394 13.548 BLBplus -120.72, 170.38 50.85, 37.0 -72.09, 126.35 41.53, 90.26 72.34, 10.44 out-out out 14.665 Saltbr-out 14.686 HRD-in -71.51, -57.81 80.53, -13.86 out-out-out SNCooo out-out ActLoopNT-out 7.398 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -104.53, 132.88 APE9-dihe-in -148.89, 164.58 APE8-dihe-in -86.44, 74.64 APE8-rot-na 29.85 APE67-dihe-in -67.97, -5.39 -28.15, -57.51 APE12-dist-na 21.355 APE11-dist-na 16.893 APE10-dist-na 15.469 APE9-dist-out 8.181 None None None XRAY 1.8 0.221 0.244 C 287 276 0 0 0 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G1TD 229 502 1130.0 No_ligand No_ligand Inactive DFGin 5.724 13.491 BLBplus -127.26, 170.73 53.33, 36.32 -70.41, 128.95 38.1, 89.88 67.15, 13.72 out-out out 14.759 Saltbr-out 14.479 HRD-in -69.96, -57.67 85.75, -24.63 out-out-out SNCooo out-out ActLoopNT-out 7.336 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.18, 134.49 APE9-dihe-in -146.03, 159.07 APE8-dihe-in -86.2, 75.17 APE8-rot-na 27.48 APE67-dihe-in -64.32, -8.55 -32.05, -58.59 APE12-dist-na 20.938 APE11-dist-na 16.469 APE10-dist-na 15.423 APE9-dist-out 8.521 None None None XRAY 1.8 0.221 0.244 D 287 274 0 0 0 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7W7XA 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.558 7.786 BABtrans -66.93, 131.45 -122.59, 21.38 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.665 Saltbr-out 7.93 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.828 APE11-dist-na 15.129 APE10-dist-na 17.953 APE9-dist-in 7.347 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272 267 2 0 0 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7W7XB 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.845 8.188 BABtrans -65.38, 135.53 -123.74, 24.69 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.036 Saltbr-out 8.33 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.562 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.996 APE10-dist-na 17.134 APE9-dist-in 6.992 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272 264 5 0 0 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4XEYB 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.001 8.022 BABtrans -71.04, 121.63 -84.68, 7.52 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.643 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.422 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.56 APE11-dist-na 13.923 APE10-dist-na 16.549 APE9-dist-in 6.428 None None None XRAY 2.891 0.232 0.259 B 408 359 9 0 0 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7N9GA 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.421 8.187 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.878 Saltbr-out 9.786 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.544 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.85 None None None XRAY 2.2 0.219 0.251 A 271 250 16 0 0 13 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7N9GC 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.762 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.439 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.891 None None None XRAY 2.2 0.219 0.251 C 271 233 33 0 0 5 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G2FA 232 506 1130.0 No_ligand No_ligand Inactive DFGinter 9.904 7.215 None -62.11, 127.98 -87.38, -14.52 -64.34, -9.9 184.11, 68.76 -103.31, 15.09 in-out in 8.923 Saltbr-out 8.97 HRD-out -103.65, 121.34 -60.45, -26.89 out-out-in SNCooi out-in ActLoopNT-out 5.537 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.48, 145.14 APE9-dihe-in -132.2, 154.35 APE8-dihe-in -76.87, 87.18 APE8-rot-na 28.49 APE67-dihe-in -66.0, -4.27 -34.28, -57.53 APE12-dist-na 21.406 APE11-dist-na 16.576 APE10-dist-na 17.867 APE9-dist-in 7.431 H396P None None XRAY 2.7 0.234 0.286 A 287 275 0 0 0 0 [[242, 495]] 1.0 2g2f TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6BL8A 233 502 1130.0 PVB:601 Type1 Inactive DFGinter 8.638 5.129 None -71.96, 143.85 -136.17, 39.9 -72.13, -37.4 288.6, 104.47 -92.65, 14.81 in-out in 8.634 Saltbr-out 7.155 HRD-in -90.04, -55.84 74.1, 2.35 out-out-in SNCooi out-in ActLoopNT-out 5.726 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.55, 128.85 APE9-dihe-in -120.75, 157.5 APE8-dihe-in -76.2, 98.23 APE8-rot-na 22.7 APE67-dihe-in -70.51, -5.85 -42.21, -49.52 APE12-dist-na 19.841 APE11-dist-na 15.131 APE10-dist-na 17.437 APE9-dist-in 7.088 None None None XRAY 2.5 0.177 0.204 A 272 270 0 0 0 0 [[242, 495]] 1.0 6bl8 TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6BL8B 233 504 1130.0 PVB:601 Type1 Inactive DFGinter 8.616 5.229 None -71.73, 142.55 -134.64, 39.69 -72.51, -38.46 288.36, 104.6 -92.85, 14.3 in-none in 8.487 Saltbr-none 999.0 HRD-in -91.59, -53.55 75.4, -2.02 none-out-in SNCnoi out-in ActLoopNT-out 5.421 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.94, 127.06 APE9-dihe-in -119.46, 155.16 APE8-dihe-in -72.29, 100.21 APE8-rot-na 22.45 APE67-dihe-in -69.04, -6.83 -41.1, -50.73 APE12-dist-na 19.223 APE11-dist-na 14.504 APE10-dist-na 17.351 APE9-dist-in 6.845 None None None XRAY 2.5 0.177 0.204 B 272 268 4 0 0 1 [[242, 495]] 1.0 6bl8 TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8I7SA 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 9.134 7.631 None -67.26, 134.08 -124.25, 38.37 -90.11, -15.51 320.43, 108.35 -104.88, 9.69 in-in in 8.711 Saltbr-in 2.997 HRD-in -101.62, -50.5 73.92, -2.89 in-out-in SNCioi out-in ActLoopNT-out 5.643 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.21, 132.08 APE9-dihe-in -105.71, 156.86 APE8-dihe-in -74.32, 88.38 APE8-rot-na 26.42 APE67-dihe-in -74.59, -6.02 -50.76, -44.43 APE12-dist-na 19.815 APE11-dist-na 15.13 APE10-dist-na 17.859 APE9-dist-in 7.511 None PTR393 PTR393 XRAY 1.946 0.186 0.216 A 272 262 7 0 0 0 [[242, 495]] 1.0 8i7s TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8I7SB 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.73 7.672 None -65.46, 135.7 -123.29, 38.43 -94.21, -15.86 318.08, 102.31 -104.7, 7.72 in-out in 8.739 Saltbr-out 4.579 HRD-in -100.98, -46.35 75.57, -9.9 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.26, 135.01 APE9-dihe-in -100.5, 152.85 APE8-dihe-in -79.3, 86.45 APE8-rot-na 26.11 APE67-dihe-in -72.94, -9.36 -50.77, -43.49 APE12-dist-na 18.49 APE11-dist-na 13.88 APE10-dist-na 16.57 APE9-dist-in 7.198 None PTR393 PTR393 XRAY 1.946 0.186 0.216 B 272 264 5 0 0 0 [[242, 495]] 1.0 8i7s TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8I7ZB 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.467 7.129 None -66.85, 127.11 -111.9, 44.88 -97.85, -10.98 300.72, 89.67 -118.62, 22.53 in-in in 8.811 Saltbr-in 3.079 HRD-in -103.27, -34.43 69.06, -16.77 in-out-in SNCioi out-in ActLoopNT-out 5.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.59, 128.54 APE9-dihe-in -113.43, 144.92 APE8-dihe-in -66.08, 92.18 APE8-rot-na 22.51 APE67-dihe-in -69.32, -14.4 -51.28, -44.78 APE12-dist-na 18.584 APE11-dist-na 13.952 APE10-dist-na 16.689 APE9-dist-in 6.907 None PTR393 PTR393 XRAY 2.255 0.177 0.213 B 272 265 4 0 0 0 [[242, 495]] 1.0 8i7z TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7W7YA 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.383 7.452 None -61.0, 140.15 -123.07, 7.15 -97.99, -19.69 299.86, 99.82 -107.54, 26.38 in-out in 7.832 Saltbr-out 4.324 HRD-in -95.67, -53.61 79.5, -5.33 out-out-in SNCooi out-in ActLoopNT-out 5.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.53, 135.86 APE9-dihe-in -112.22, 154.02 APE8-dihe-in -72.0, 92.74 APE8-rot-na 26.94 APE67-dihe-in -71.4, -8.88 -51.03, -45.88 APE12-dist-na 19.642 APE11-dist-na 14.989 APE10-dist-na 18.032 APE9-dist-in 7.453 None PTR393 PTR393 XRAY 2.2 0.176 0.201 A 276 269 0 0 0 0 [[242, 495]] 1.0 7w7y TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7W7YB 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.706 7.939 None -67.02, 132.31 -125.55, 45.99 -104.04, 122.68 325.21, 94.33 94.56, 12.27 in-out in 9.12 Saltbr-out 4.526 HRD-in -107.75, -54.39 71.9, 2.12 out-out-in SNCooi out-in ActLoopNT-out 5.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.81, 139.55 APE9-dihe-in -122.0, 156.17 APE8-dihe-in -66.34, 94.72 APE8-rot-na 24.45 APE67-dihe-in -67.89, -13.14 -48.19, -46.95 APE12-dist-na 18.655 APE11-dist-na 14.121 APE10-dist-na 17.512 APE9-dist-in 7.157 None PTR393 PTR393 XRAY 2.2 0.176 0.201 B 276 267 2 0 0 0 [[242, 495]] 1.0 7w7y TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8H7FA 232 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.439 7.331 None -69.17, 127.91 -123.7, 53.27 -97.59, -18.49 298.04, 92.12 -115.41, 32.43 in-none in 7.913 Saltbr-none 999.0 HRD-in -98.47, -51.88 73.34, 1.6 none-out-in SNCnoi out-in ActLoopNT-out 5.774 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.81, 130.64 APE9-dihe-in -111.12, 149.71 APE8-dihe-in -68.85, 91.65 APE8-rot-na 24.28 APE67-dihe-in -80.23, -2.27 -54.19, -39.54 APE12-dist-na 19.803 APE11-dist-na 15.167 APE10-dist-na 17.763 APE9-dist-in 7.415 None PTR393 PTR393 XRAY 2.45 0.206 0.234 A 277 267 2 0 0 0 [[242, 495]] 1.0 8h7f TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8H7FB 233 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.625 7.629 None -66.82, 132.57 -128.02, 53.13 -102.99, -16.57 308.49, 91.71 -113.57, 28.76 in-none in 8.398 Saltbr-none 999.0 HRD-out -118.2, 104.8 -89.8, 17.52 none-out-in SNCnoi out-in ActLoopNT-out 5.639 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.35, 131.94 APE9-dihe-in -101.32, 145.24 APE8-dihe-in -82.14, 94.32 APE8-rot-na 25.72 APE67-dihe-in -72.86, -15.28 -51.55, -45.38 APE12-dist-na 18.504 APE11-dist-na 13.782 APE10-dist-na 16.382 APE9-dist-in 7.368 None PTR393 PTR393 XRAY 2.45 0.206 0.234 B 277 257 11 0 0 0 [[242, 495]] 1.0 8h7f TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8H7HA 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.39 7.687 None -66.88, 126.67 -122.6, 45.68 -99.68, -4.7 302.75, 91.96 -123.88, 23.24 in-none in 8.036 Saltbr-none 999.0 HRD-in -99.74, -50.53 75.81, -4.43 none-out-in SNCnoi out-in ActLoopNT-out 5.704 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.51, 132.84 APE9-dihe-in -111.46, 154.74 APE8-dihe-in -71.0, 89.59 APE8-rot-na 25.0 APE67-dihe-in -73.93, -5.32 -52.54, -45.5 APE12-dist-na 19.749 APE11-dist-na 15.182 APE10-dist-na 18.067 APE9-dist-in 7.438 None PTR393 PTR393 XRAY 2.278 0.185 0.221 A 277 269 0 0 0 0 [[242, 495]] 1.0 8h7h TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8H7HB 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.489 7.865 None -64.21, 134.18 -129.36, 51.05 -106.57, -14.6 307.18, 95.7 -114.91, 23.11 in-none in 8.74 Saltbr-none 999.0 HRD-in -105.06, -54.2 71.08, 0.92 none-out-in SNCnoi out-in ActLoopNT-out 5.593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.95, 127.69 APE9-dihe-in -114.73, 145.44 APE8-dihe-in -67.21, 95.26 APE8-rot-na 23.35 APE67-dihe-in -67.71, -18.52 -54.95, -42.72 APE12-dist-na 18.697 APE11-dist-na 13.937 APE10-dist-na 16.449 APE9-dist-in 6.698 None PTR393 PTR393 XRAY 2.278 0.185 0.221 B 277 258 11 0 0 0 [[242, 495]] 1.0 8h7h TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4ZOGA 233 501 1130.0 VX6:601 Type1 Inactive DFGinter 9.034 8.188 None -67.97, 132.1 -127.82, 25.62 -66.74, -66.47 163.98, 49.73 -79.37, 45.35 out-out out 10.975 Saltbr-out 6.767 HRD-out -91.32, 151.74 -125.52, 16.46 out-out-in SNCooi out-in ActLoopNT-out 5.502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.42, 138.31 APE9-dihe-in -118.45, 160.42 APE8-dihe-in -78.39, 96.94 APE8-rot-na 30.14 APE67-dihe-in -71.46, -10.56 -52.82, -45.85 APE12-dist-na 19.808 APE11-dist-na 15.163 APE10-dist-na 17.423 APE9-dist-in 7.144 None None None XRAY 2.3 0.187 0.233 A 283 269 0 0 0 0 [[242, 495]] 1.0 4zog TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7CC2A 233 501 1130.0 FVC:601 Type1 Inactive DFGinter 9.165 8.258 None -73.32, 112.44 -109.3, 64.01 -105.28, -20.44 309.47, 116.75 -109.01, 28.74 out-out out 11.085 Saltbr-out 8.369 HRD-in -90.34, -46.17 72.58, 0.36 out-out-in SNCooi out-in ActLoopNT-out 5.617 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.21, 129.2 APE9-dihe-in -111.79, 156.63 APE8-dihe-in -66.39, 106.43 APE8-rot-na 344.92 APE67-dihe-in -73.87, -6.7 -58.13, -47.58 APE12-dist-na 19.252 APE11-dist-na 14.472 APE10-dist-na 17.321 APE9-dist-in 6.862 None None None XRAY 2.723 0.196 0.242 A 310 263 6 0 0 0 [[242, 495]] 1.0 7cc2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7CC2B 232 501 1130.0 FVC:601 Type1 Inactive DFGinter 8.979 8.607 None -71.77, 114.13 -110.49, 61.26 -109.45, -24.12 312.83, 116.95 -111.64, 29.87 in-none in 9.541 Saltbr-none 999.0 HRD-in -88.51, -47.46 71.59, 1.41 none-out-in SNCnoi out-in ActLoopNT-out 5.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.35, 131.77 APE9-dihe-in -108.11, 154.53 APE8-dihe-in -67.24, 106.75 APE8-rot-na 21.35 APE67-dihe-in -74.13, -7.58 -57.65, -47.12 APE12-dist-na 19.108 APE11-dist-na 14.389 APE10-dist-na 17.586 APE9-dist-in 7.008 None None None XRAY 2.723 0.196 0.242 B 310 266 4 0 0 0 [[242, 495]] 1.0 7cc2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7DT2A 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.472 7.396 None -67.36, 135.71 -126.94, 46.3 -101.94, -14.95 304.55, 98.79 -112.2, 27.67 in-out in 9.0 Saltbr-out 3.798 HRD-in -98.03, -51.7 81.6, -7.87 out-out-in SNCooi out-in ActLoopNT-out 5.749 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.44, 133.63 APE9-dihe-in -118.19, 150.76 APE8-dihe-in -62.24, 99.73 APE8-rot-na 22.52 APE67-dihe-in -73.29, -7.91 -58.82, -45.37 APE12-dist-na 19.606 APE11-dist-na 14.956 APE10-dist-na 17.818 APE9-dist-in 7.259 None None None XRAY 2.3 0.208 0.237 A 310 265 3 0 0 0 [[242, 495]] 1.0 7dt2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
7DT2B 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.633 7.853 None -67.09, 137.47 -125.9, 46.84 -103.12, -16.04 307.9, 99.91 -112.15, 26.28 in-out in 9.594 Saltbr-out 4.084 HRD-in -96.99, -47.74 84.36, -13.26 out-out-in SNCooi out-in ActLoopNT-out 5.563 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.22, 136.31 APE9-dihe-in -118.25, 150.94 APE8-dihe-in -59.92, 103.33 APE8-rot-na 21.91 APE67-dihe-in -72.55, -10.92 -57.38, -43.07 APE12-dist-na 18.628 APE11-dist-na 13.965 APE10-dist-na 17.355 APE9-dist-in 6.665 None None None XRAY 2.3 0.208 0.237 B 310 267 1 0 0 0 [[242, 495]] 1.0 7dt2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G2HA 233 504 1130.0 P16:60532 Type1 Inactive DFGinter 10.338 7.763 None -69.8, 139.79 -117.08, 21.66 -74.78, -30.76 182.98, 70.09 -83.63, 27.99 in-out in 8.947 Saltbr-out 8.475 HRD-out -106.09, 125.25 -68.95, -15.96 out-out-in SNCooi out-in ActLoopNT-out 5.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.55, 116.51 APE9-dihe-in -118.82, 162.2 APE8-dihe-in -67.24, 92.86 APE8-rot-na 32.82 APE67-dihe-in -70.58, -6.79 -39.4, -50.98 APE12-dist-na 19.946 APE11-dist-na 15.235 APE10-dist-na 17.204 APE9-dist-in 6.534 H396P None None XRAY 2.0 0.194 0.213 A 287 272 0 0 0 0 [[242, 495]] 1.0 2g2h TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4XEYA 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.927 None -70.89, 123.51 -90.91, 18.27 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.948 Saltbr-out 8.69 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.73 APE11-dist-na 14.108 APE10-dist-na 16.542 APE9-dist-in 6.588 None None None XRAY 2.891 0.232 0.259 A 408 269 4 0 0 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8I7ZA 232 499 1130.0 6CI:601,BAL:602 Type1,Type1 Inactive DFGinter 8.675 7.469 None -68.15, 124.34 -115.26, 44.89 -92.28, -20.89 299.64, 92.88 -113.55, 33.09 in-none in 9.013 Saltbr-none 999.0 HRD-in -101.45, -51.38 75.46, -1.93 none-out-in SNCnoi out-in ActLoopNT-out 5.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.91, 129.83 APE9-dihe-in -107.25, 158.29 APE8-dihe-in -77.21, 88.15 APE8-rot-na 26.6 APE67-dihe-in -78.48, -3.49 -49.13, -44.82 APE12-dist-na 19.991 APE11-dist-na 15.346 APE10-dist-na 18.074 APE9-dist-in 7.513 None PTR393 PTR393 XRAY 2.255 0.177 0.213 A 272 258 10 0 0 0 [[242, 495]] 1.0 8i7z TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4YC8A 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.254 9.479 None -68.71, 128.66 -122.3, 46.03 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.142 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.44 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.127 APE11-dist-na 14.45 APE10-dist-na 17.471 APE9-dist-in 6.747 None None None XRAY 2.9 0.199 0.24 A 287 259 10 0 0 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4YC8B 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.555 9.692 None -74.12, 129.26 -121.25, 39.81 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.822 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.669 APE11-dist-na 14.989 APE10-dist-na 17.785 APE9-dist-in 6.93 None None None XRAY 2.9 0.199 0.24 B 287 264 6 0 0 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
9KS5A 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.73 5.596 None -72.67, 142.35 -137.94, 44.53 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.005 Saltbr-na 6.545 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.819 APE11-dist-na 15.248 APE10-dist-na 18.1 APE9-dist-in 7.545 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272 267 1 0 0 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
9KS5B 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.971 5.847 None -69.26, 149.18 -127.32, 25.05 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.96 Saltbr-na 6.29 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.464 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.424 APE11-dist-na 14.058 APE10-dist-na 17.265 APE9-dist-in 6.892 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272 268 0 0 0 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6XRGA 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.006 8.697 BBAminus -171.83, 165.33 -155.54, 133.54 -84.4, -28.08 302.76, 128.31 104.78, 35.25 in-in in 8.063 Saltbr-in 3.14 HRD-in -67.57, -50.13 76.12, -27.45 in-out-out SNCioo out-out ActLoopNT-out 18.414 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -124.03, 17.56 APE9-dihe-in -95.78, 148.38 APE8-dihe-in -59.62, 96.75 APE8-rot-na 336.69 APE67-dihe-in -65.49, -36.89 -72.8, -27.02 APE12-dist-na 14.4 APE11-dist-na 13.457 APE10-dist-na 9.211 APE9-dist-in 6.36 G250E,M290L,T389Y None None NMR 999.0 999.0 999.0 A 287 287 0 0 0 0 [[242, 495]] 1.0 6xrg TYR_ABL1_HUMAN TYR 1.3e-100 341.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3QRJA 234 496 1130.0 919:2 Type2 Inactive DFGout 13.149 8.99 BBAminus -140.1, 177.46 -140.75, 104.13 -86.94, 4.73 283.88, 85.78 63.32, 48.64 in-in in 7.673 Saltbr-in 2.775 HRD-in -79.02, -49.06 80.26, -14.09 in-out-in SNCioi out-in ActLoopNT-out 14.988 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.38, 130.47 APE9-dihe-in -139.16, 150.69 APE8-dihe-in -78.39, 79.63 APE8-rot-na 34.62 APE67-dihe-in -72.48, -9.29 -46.12, -53.19 APE12-dist-na 18.622 APE11-dist-na 15.645 APE10-dist-na 10.845 APE9-dist-in 7.358 T315I None None XRAY 1.82 0.232 0.286 A 277 258 5 0 0 0 [[242, 495]] 1.0 3qrj TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3QRJB 233 497 1130.0 919:1 Type2 Inactive DFGout 13.129 9.079 BBAminus -139.41, 169.11 -133.48, 106.22 -82.14, 0.45 283.14, 89.48 61.09, 48.15 in-in in 7.931 Saltbr-in 2.795 HRD-in -78.78, -56.83 82.44, -6.52 in-out-in SNCioi out-in ActLoopNT-out 15.105 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.29, 121.26 APE9-dihe-in -134.93, 153.91 APE8-dihe-in -77.7, 85.51 APE8-rot-na 33.76 APE67-dihe-in -63.53, -18.09 -55.44, -46.47 APE12-dist-na 18.656 APE11-dist-na 15.376 APE10-dist-na 10.823 APE9-dist-in 7.722 T315I None None XRAY 1.82 0.232 0.286 B 277 265 0 0 0 0 [[242, 495]] 1.0 3qrj TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HZ0A 233 497 1130.0 GIN:600 Type2 Inactive DFGout 16.315 10.475 BBAminus -150.83, -160.56 -160.34, 120.0 -81.87, -18.31 276.95, 79.02 -92.52, 170.28 in-in in 7.814 Saltbr-in 2.696 HRD-in -75.66, -51.7 79.36, -13.13 in-out-in SNCioi out-in ActLoopNT-out 6.647 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.12, 134.88 APE9-dihe-in -108.63, 131.61 APE8-dihe-in -62.36, 119.6 APE8-rot-na 29.91 APE67-dihe-in -70.7, -20.49 -52.84, -40.81 APE12-dist-na 12.461 APE11-dist-na 9.603 APE10-dist-na 12.547 APE9-dist-in 6.155 None None None XRAY 2.1 0.195 0.256 A 270 265 0 0 0 0 [[242, 495]] 1.0 2hz0 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HZ0B 228 497 1130.0 GIN:600 Type2 Inactive DFGout 16.145 10.288 BBAminus -144.12, -165.06 -157.27, 107.1 -67.75, -17.6 276.47, 79.62 51.54, 32.42 in-in in 7.851 Saltbr-in 2.502 HRD-in -77.02, -51.65 87.26, -10.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.38 APE8-rot-na 355.54 APE67-dihe-in -66.19, -16.4 -42.69, -41.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.195 0.256 B 270 243 27 0 0 17 [[242, 495]] 1.0 2hz0 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HYYA 235 498 1130.0 STI:600 Type2 Inactive DFGout 13.448 10.936 BBAminus -136.71, -169.54 -156.86, 107.67 -99.35, 1.46 307.94, 127.18 66.47, 52.08 in-in in 8.239 Saltbr-in 3.004 HRD-in -68.42, -63.13 91.16, -9.54 in-out-in SNCioi out-in ActLoopNT-out 16.099 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.4, 131.38 APE9-dihe-in -122.46, 141.0 APE8-dihe-in -82.09, 92.82 APE8-rot-na 22.51 APE67-dihe-in -74.51, -8.92 -44.66, -47.4 APE12-dist-na 14.458 APE11-dist-na 11.901 APE10-dist-na 8.415 APE9-dist-in 7.394 None None None XRAY 2.4 0.208 0.267 A 273 263 1 0 0 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HYYB 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.607 10.838 BBAminus -140.46, -179.87 -145.37, 104.9 -88.0, -4.17 302.17, 134.32 68.19, 47.44 in-in in 8.468 Saltbr-in 2.974 HRD-in -72.33, -53.74 81.02, -14.85 in-out-in SNCioi out-in ActLoopNT-out 15.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.08, 127.85 APE9-dihe-in -116.06, 145.63 APE8-dihe-in -88.84, 91.14 APE8-rot-na 22.78 APE67-dihe-in -77.2, -5.94 -46.52, -42.21 APE12-dist-na 14.479 APE11-dist-na 11.949 APE10-dist-na 8.421 APE9-dist-in 7.417 None None None XRAY 2.4 0.208 0.267 B 273 265 1 0 0 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HYYC 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.817 11.145 BBAminus -136.58, -170.43 -156.15, 102.72 -91.16, -2.19 306.71, 138.1 61.3, 49.16 in-in in 8.291 Saltbr-in 3.409 HRD-in -75.29, -48.77 83.65, -17.42 in-out-in SNCioi out-in ActLoopNT-out 15.636 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.7, 128.89 APE9-dihe-in -132.69, 141.39 APE8-dihe-in -86.44, 89.34 APE8-rot-na 30.23 APE67-dihe-in -75.71, -10.45 -48.99, -40.28 APE12-dist-na 15.628 APE11-dist-na 13.532 APE10-dist-na 8.776 APE9-dist-in 7.515 None None None XRAY 2.4 0.208 0.267 C 273 262 4 0 0 3 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HYYD 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.627 11.008 BBAminus -135.11, -170.82 -155.12, 109.43 -96.64, 9.5 309.68, 132.23 60.03, 43.1 in-in in 8.009 Saltbr-in 2.758 HRD-in -69.95, -55.57 86.15, -21.95 in-out-in SNCioi out-in ActLoopNT-out 15.335 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 121.23 APE9-dihe-in -126.0, 140.68 APE8-dihe-in -79.93, 90.29 APE8-rot-na 35.26 APE67-dihe-in -80.44, -14.01 -57.15, -31.16 APE12-dist-na 15.675 APE11-dist-na 13.475 APE10-dist-na 8.574 APE9-dist-in 7.555 None None None XRAY 2.4 0.208 0.267 D 273 264 2 0 0 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3CS9A 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.593 11.118 BBAminus -145.37, -175.21 -153.52, 95.68 -79.44, 2.63 308.67, 139.53 60.14, 48.09 in-in in 7.987 Saltbr-in 2.959 HRD-in -72.5, -52.05 83.05, -14.51 in-out-in SNCioi out-in ActLoopNT-out 15.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.13, 125.61 APE9-dihe-in -114.38, 144.88 APE8-dihe-in -83.08, 84.52 APE8-rot-na 33.34 APE67-dihe-in -71.16, -7.94 -52.7, -43.38 APE12-dist-na 15.638 APE11-dist-na 11.341 APE10-dist-na 8.586 APE9-dist-in 7.762 None None None XRAY 2.21 0.2 0.242 A 277 264 4 0 0 0 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3CS9B 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.456 10.753 BBAminus -144.0, -176.67 -148.15, 110.4 -103.8, 0.8 309.16, 135.76 150.34, 999.0 in-in in 8.222 Saltbr-in 3.48 HRD-in -70.96, -54.76 81.36, -12.94 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.55 APE8-rot-na 31.92 APE67-dihe-in -70.26, -17.41 -42.99, -45.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 B 277 247 21 0 0 18 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3CS9C 232 497 1130.0 NIL:600 Type2 Inactive DFGout 13.712 10.918 BBAminus -141.39, 177.78 -141.43, 100.61 -84.1, -4.94 304.15, 138.08 61.69, 999.0 in-in in 7.955 Saltbr-in 2.828 HRD-in -74.87, -48.82 81.89, -13.85 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.51 APE8-rot-na 36.98 APE67-dihe-in -69.35, -10.43 -43.96, -42.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 C 277 243 23 0 0 18 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3CS9D 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.778 11.757 BBAminus -137.25, -170.7 -151.81, 104.77 -89.11, 0.3 306.25, 137.53 63.13, 44.73 in-in in 7.888 Saltbr-in 2.74 HRD-in -68.82, -44.23 79.28, -14.07 in-out-in SNCioi out-in ActLoopNT-out 15.59 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.05, 117.02 APE9-dihe-in -109.67, 147.03 APE8-dihe-in -87.1, 85.65 APE8-rot-na 29.26 APE67-dihe-in -63.61, -19.67 -51.69, -46.78 APE12-dist-na 16.15 APE11-dist-na 12.15 APE10-dist-na 8.758 APE9-dist-in 7.581 None None None XRAY 2.21 0.2 0.242 D 277 263 5 0 0 0 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3QRIA 229 498 1130.0 919:60500 Type2 Inactive DFGout 13.405 9.244 BBAminus -140.23, -177.67 -143.73, 111.06 -85.62, -1.21 285.71, 95.83 64.84, 45.13 in-in in 7.938 Saltbr-in 2.671 HRD-in -68.59, -54.98 84.86, -16.08 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.68, 128.64 APE9-dihe-in -141.86, 154.54 APE8-dihe-in -79.64, 85.81 APE8-rot-na 26.51 APE67-dihe-in -72.47, -7.02 -44.71, -48.72 APE12-dist-na 18.499 APE11-dist-na 15.586 APE10-dist-na 10.726 APE9-dist-in 7.426 None None None XRAY 2.1 0.216 0.272 A 277 270 0 0 0 0 [[242, 495]] 1.0 3qri TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3QRIB 232 498 1130.0 919:60002 Type2 Inactive DFGout 13.394 9.355 BBAminus -137.99, -177.06 -143.59, 113.56 -88.43, -2.03 287.13, 98.7 64.72, 47.42 in-in in 7.851 Saltbr-in 2.857 HRD-in -75.25, -51.53 85.01, -17.97 in-out-in SNCioi out-in ActLoopNT-out 15.327 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.54, 128.19 APE9-dihe-in -140.43, 156.29 APE8-dihe-in -80.95, 78.25 APE8-rot-na 29.21 APE67-dihe-in -73.74, -7.02 -42.67, -45.53 APE12-dist-na 18.487 APE11-dist-na 15.562 APE10-dist-na 10.79 APE9-dist-in 7.48 None None None XRAY 2.1 0.216 0.272 B 277 262 5 0 0 0 [[242, 495]] 1.0 3qri TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HIWA 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.347 10.826 BBAminus -142.71, -168.33 -158.01, 107.74 -97.35, 2.37 312.36, 126.58 65.32, 50.81 in-out in 8.229 Saltbr-out 3.74 HRD-in -73.86, -48.39 84.66, -24.64 out-out-in SNCooi out-in ActLoopNT-out 15.637 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 130.36 APE9-dihe-in -115.68, 135.96 APE8-dihe-in -85.15, 68.17 APE8-rot-na 24.2 APE67-dihe-in -72.17, -12.42 -32.25, -48.66 APE12-dist-na 13.573 APE11-dist-na 12.475 APE10-dist-na 8.19 APE9-dist-in 7.724 None None None XRAY 2.2 0.246 0.309 A 287 270 0 0 0 0 [[242, 495]] 1.0 2hiw TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HIWB 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.088 11.207 BBAminus -144.46, -168.71 -161.12, 102.71 -97.39, 4.98 318.67, 117.06 56.31, 54.08 in-in in 8.015 Saltbr-in 2.787 HRD-in -67.44, -50.02 79.19, -15.91 in-out-in SNCioi out-in ActLoopNT-out 15.965 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.79, 117.59 APE9-dihe-in -110.67, 133.98 APE8-dihe-in -80.14, 91.72 APE8-rot-na 27.82 APE67-dihe-in -76.13, -9.39 -64.08, -40.93 APE12-dist-na 14.695 APE11-dist-na 12.519 APE10-dist-na 8.495 APE9-dist-in 7.672 None None None XRAY 2.2 0.246 0.309 B 287 270 0 0 0 0 [[242, 495]] 1.0 2hiw TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2E2BA 229 502 1130.0 406:61001 Type2 Inactive DFGout 13.637 10.914 BBAminus -135.1, -171.45 -153.85, 101.44 -92.52, 5.9 308.25, 136.28 52.63, 55.21 in-in in 8.439 Saltbr-in 2.958 HRD-in -72.49, -53.7 81.83, -19.66 in-out-in SNCioi out-in ActLoopNT-out 15.483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.77, 121.49 APE9-dihe-in -121.85, 146.58 APE8-dihe-in -80.67, 88.23 APE8-rot-na 34.75 APE67-dihe-in -71.79, -9.02 -46.22, -43.83 APE12-dist-na 15.609 APE11-dist-na 11.355 APE10-dist-na 8.517 APE9-dist-in 7.271 None None None XRAY 2.2 0.236 0.27 A 293 266 8 0 0 4 [[242, 495]] 1.0 2e2b TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2E2BB 229 497 1130.0 406:61002 Type2 Inactive DFGout 13.647 10.933 BBAminus -143.5, -176.35 -149.87, 101.4 -87.9, 0.31 305.42, 141.47 55.35, 49.49 in-in in 8.452 Saltbr-in 2.852 HRD-in -72.44, -52.01 77.65, -14.12 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.83, 116.83 APE9-dihe-in -124.88, 142.96 APE8-dihe-in -78.59, 83.23 APE8-rot-na 29.89 APE67-dihe-in -65.0, -9.5 -42.19, -50.29 APE12-dist-na 15.656 APE11-dist-na 11.831 APE10-dist-na 8.469 APE9-dist-in 7.22 None None None XRAY 2.2 0.236 0.27 B 293 258 11 0 0 6 [[242, 495]] 1.0 2e2b TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
5HU9A 229 499 1130.0 66K:60601,66K:60602 Type2,Allosteric Inactive DFGout 15.803 10.497 BBAminus -145.4, -177.31 -141.71, 111.16 -69.31, -26.01 283.1, 65.03 93.44, 13.86 in-in in 8.083 Saltbr-in 2.769 HRD-in -68.36, -51.36 83.46, -11.3 in-out-out SNCioo out-out ActLoopNT-out 13.313 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -72.36, -42.02 APE9-dihe-in -132.05, 79.59 APE8-dihe-in -81.54, 66.0 APE8-rot-na 26.81 APE67-dihe-in -69.94, -12.93 -59.43, -37.79 APE12-dist-na 9.509 APE11-dist-na 5.455 APE10-dist-na 6.094 APE9-dist-out 9.516 None None None XRAY 1.529 0.186 0.196 A 277 266 5 0 0 5 [[242, 495]] 1.0 5hu9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3PYYA 232 500 1130.0 STI:60003,3YY:60538 Type2,Allosteric Inactive DFGout 13.647 11.262 BBAminus -130.42, -173.45 -148.82, 100.51 -87.29, -2.92 301.78, 132.98 62.26, 50.77 in-in in 8.143 Saltbr-in 2.677 HRD-in -77.84, -60.13 91.69, -13.02 in-out-in SNCioi out-in ActLoopNT-out 15.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.57, 117.7 APE9-dihe-in -121.79, 141.76 APE8-dihe-in -85.05, 87.91 APE8-rot-na 30.64 APE67-dihe-in -73.12, -6.21 -47.76, -45.73 APE12-dist-na 16.525 APE11-dist-na 12.81 APE10-dist-na 8.696 APE9-dist-in 7.729 None None None XRAY 1.85 0.189 0.204 A 298 265 4 0 0 0 [[242, 495]] 1.0 3pyy TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3PYYB 233 510 1130.0 STI:60004,3YY:60532 Type2,Allosteric Inactive DFGout 13.97 11.017 BBAminus -132.59, -172.42 -152.94, 105.37 -94.38, -50.82 313.04, 135.61 93.2, 999.0 in-in in 8.1 Saltbr-in 2.571 HRD-in -81.0, -57.03 86.3, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -127.99, 138.02 APE9-dihe-in -152.66, 146.9 APE8-dihe-in -80.16, 79.64 APE8-rot-na 29.64 APE67-dihe-in -75.32, -11.37 -49.83, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.258 None None None XRAY 1.85 0.189 0.204 B 298 257 21 0 0 15 [[242, 495]] 1.0 3pyy TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6NPEA 232 500 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.751 11.277 BBAminus -132.09, -171.87 -150.82, 100.43 -86.72, -1.03 301.5, 131.9 61.32, 51.13 in-in in 8.171 Saltbr-in 2.779 HRD-in -75.05, -56.53 78.97, -9.5 in-out-in SNCioi out-in ActLoopNT-out 15.736 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.77, 121.63 APE9-dihe-in -123.35, 140.69 APE8-dihe-in -84.02, 84.76 APE8-rot-na 23.95 APE67-dihe-in -76.42, -6.93 -49.4, -44.5 APE12-dist-na 16.592 APE11-dist-na 12.788 APE10-dist-na 8.752 APE9-dist-in 7.844 None None None XRAY 2.15 0.187 0.212 A 298 264 5 0 0 0 [[242, 495]] 1.0 6npe TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6NPEB 233 511 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.84 11.101 BBAminus -129.89, -169.38 -152.66, 105.04 -92.73, -27.9 303.95, 134.44 82.3, 999.0 in-in in 8.222 Saltbr-in 2.684 HRD-in -80.48, -54.98 79.49, -7.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.9 APE8-dihe-in -75.88, 86.79 APE8-rot-na 23.52 APE67-dihe-in -70.62, -18.32 -51.39, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.686 None None None XRAY 2.15 0.187 0.212 B 298 256 23 0 0 17 [[242, 495]] 1.0 6npe TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6NPUA 232 500 1130.0 STI:60601,KWV:60602 Type2,Allosteric Inactive DFGout 13.724 11.341 BBAminus -131.32, -177.82 -147.63, 103.5 -91.61, -2.68 302.6, 133.1 64.49, 56.03 in-in in 8.175 Saltbr-in 2.643 HRD-in -76.28, -58.38 85.82, -8.07 in-out-in SNCioi out-in ActLoopNT-out 15.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 129.98 APE9-dihe-in -123.79, 139.52 APE8-dihe-in -78.9, 90.13 APE8-rot-na 28.21 APE67-dihe-in -75.75, -3.63 -52.56, -44.81 APE12-dist-na 16.312 APE11-dist-na 12.598 APE10-dist-na 8.715 APE9-dist-in 7.801 None None None XRAY 2.33 0.196 0.234 A 298 264 5 0 0 0 [[242, 495]] 1.0 6npu TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6NPUB 233 510 1130.0 STI:60602,KWV:60605 Type2,Allosteric Inactive DFGout 13.716 11.121 BBAminus -136.03, -173.76 -148.73, 104.54 -94.68, -39.85 309.09, 136.14 93.88, 999.0 in-in in 8.046 Saltbr-in 2.655 HRD-in -88.42, -57.18 82.99, -10.02 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.51, 88.48 APE9-dihe-in -97.46, 155.87 APE8-dihe-in -87.38, 82.63 APE8-rot-na 29.77 APE67-dihe-in -64.85, -22.06 -45.68, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.855 None None None XRAY 2.33 0.196 0.234 B 298 257 21 0 0 15 [[242, 495]] 1.0 6npu TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6NPVA 232 500 1130.0 STI:60602,KWP:60603 Type2,Allosteric Inactive DFGout 13.575 11.211 BBAminus -133.43, -176.32 -147.26, 102.27 -88.44, -2.86 301.02, 133.29 64.03, 50.03 in-in in 8.158 Saltbr-in 2.969 HRD-in -74.61, -59.03 88.55, -10.34 in-out-in SNCioi out-in ActLoopNT-out 15.738 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.7, 120.65 APE9-dihe-in -115.73, 140.1 APE8-dihe-in -81.63, 87.3 APE8-rot-na 30.14 APE67-dihe-in -75.75, -5.01 -52.83, -44.97 APE12-dist-na 16.303 APE11-dist-na 12.284 APE10-dist-na 8.713 APE9-dist-in 7.782 None None None XRAY 1.86 0.183 0.207 A 298 264 5 0 0 0 [[242, 495]] 1.0 6npv TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6NPVB 233 510 1130.0 STI:60603,KWP:60607 Type2,Allosteric Inactive DFGout 13.545 11.062 BBAminus -135.7, -168.07 -155.88, 101.76 -93.13, -7.53 306.52, 136.97 78.01, 999.0 in-in in 8.2 Saltbr-in 2.751 HRD-in -76.84, -57.95 84.26, -8.39 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.75, 102.42 APE9-dihe-in -114.18, 151.63 APE8-dihe-in -86.78, 85.36 APE8-rot-na 20.0 APE67-dihe-in -75.22, -6.58 -51.86, -43.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.966 None None None XRAY 1.86 0.183 0.207 B 298 257 21 0 0 15 [[242, 495]] 1.0 6npv TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3QRKA 229 496 1130.0 9DP:60001 Type3 Inactive DFGout 13.538 9.263 BBAminus -128.74, -174.73 -147.03, 106.14 -83.7, 8.0 281.11, 96.68 56.22, 46.71 in-in in 7.853 Saltbr-in 2.674 HRD-in -77.83, -51.71 87.8, -21.18 in-out-in SNCioi out-in ActLoopNT-out 15.303 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.14, 132.07 APE9-dihe-in -145.7, 147.79 APE8-dihe-in -79.52, 88.76 APE8-rot-na 26.7 APE67-dihe-in -65.94, -15.53 -54.88, -43.49 APE12-dist-na 18.815 APE11-dist-na 15.758 APE10-dist-na 10.991 APE9-dist-in 7.585 None None None XRAY 2.3 0.192 0.281 A 277 268 0 0 0 0 [[242, 495]] 1.0 3qrk TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G2FB 234 502 1130.0 AGS:601 ATPlike Inactive DFGout 13.477 11.525 None -73.05, 151.22 -78.4, -31.56 -2.81, -74.15 167.03, 54.1 -90.78, 24.63 in-in in 8.896 Saltbr-in 3.373 HRD-out -112.09, 115.32 -73.34, -1.05 in-out-in SNCioi out-in ActLoopNT-out 5.759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.67, 144.36 APE9-dihe-in -134.57, 156.36 APE8-dihe-in -59.22, 104.92 APE8-rot-na 31.18 APE67-dihe-in -59.35, -15.8 -52.01, -51.94 APE12-dist-na 18.887 APE11-dist-na 14.3 APE10-dist-na 17.687 APE9-dist-in 6.818 H396P None None XRAY 2.7 0.234 0.286 B 287 264 5 0 0 0 [[242, 495]] 1.0 2g2f TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
6XR7A 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.443 8.628 None -113.31, -174.74 -119.02, 30.04 -65.72, 104.77 191.29, 77.0 102.04, -118.08 in-in in 7.642 Saltbr-in 2.805 HRD-in -104.45, -51.55 70.39, 1.66 in-out-out SNCioo out-out ActLoopNT-out 4.962 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 60.98, -93.15 APE9-dihe-out 55.27, 119.08 APE8-dihe-in -62.33, 109.76 APE8-rot-na 22.3 APE67-dihe-in -67.97, -13.01 -57.05, -38.83 APE12-dist-na 12.258 APE11-dist-na 9.513 APE10-dist-na 11.208 APE9-dist-in 7.706 None None None NMR 999.0 999.0 999.0 A 287 287 0 0 0 0 [[242, 495]] 1.0 6xr7 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8I7TB 232 500 1130.0 6I5:601 Type1 Inactive DFGout 13.413 11.662 None -78.21, 133.76 -76.1, -34.26 58.37, -123.75 266.71, 82.63 -125.63, 98.01 in-in in 9.576 Saltbr-in 3.259 HRD-in -106.12, -52.02 70.25, 2.56 in-out-in SNCioi out-in ActLoopNT-out 5.657 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.56, 141.45 APE9-dihe-in -118.71, 149.22 APE8-dihe-in -71.44, 98.5 APE8-rot-na 25.12 APE67-dihe-in -70.33, -18.58 -57.67, -41.4 APE12-dist-na 18.142 APE11-dist-na 13.598 APE10-dist-na 16.985 APE9-dist-in 6.851 None PTR393 PTR393 XRAY 2.8 0.221 0.272 B 272 263 6 0 0 0 [[242, 495]] 1.0 8i7t TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HZIA 233 500 1130.0 JIN:600 Type1 Inactive DFGout 12.672 11.025 None -64.65, 136.57 -117.47, 21.9 -67.4, 155.9 48.8, 72.68 74.75, 2.18 in-in in 8.01 Saltbr-in 2.751 HRD-in -100.41, -50.8 74.37, -4.5 in-out-in SNCioi out-in ActLoopNT-out 5.602 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.67, 131.39 APE9-dihe-in -115.42, 162.87 APE8-dihe-in -80.35, 88.85 APE8-rot-na 20.47 APE67-dihe-in -70.91, -11.25 -48.9, -44.37 APE12-dist-na 19.444 APE11-dist-na 14.856 APE10-dist-na 17.691 APE9-dist-in 7.179 None None None XRAY 1.7 0.177 0.204 A 277 268 0 0 0 0 [[242, 495]] 1.0 2hzi TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4ZOGB 234 503 1130.0 VX6:601 Type1 Inactive DFGout 11.789 11.828 None -72.45, 126.77 -115.82, 44.9 -59.71, -111.34 30.08, 49.18 -63.43, 48.35 in-in in 8.88 Saltbr-in 3.108 HRD-in -92.87, -52.54 77.42, -2.86 in-out-in SNCioi out-in ActLoopNT-out 5.5 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.26, 120.92 APE9-dihe-in -100.0, 141.29 APE8-dihe-in -74.27, 97.66 APE8-rot-na 25.54 APE67-dihe-in -72.2, -10.54 -59.59, -40.07 APE12-dist-na 17.856 APE11-dist-na 13.858 APE10-dist-na 16.207 APE9-dist-in 6.99 None None None XRAY 2.3 0.187 0.233 B 283 268 2 0 0 2 [[242, 495]] 1.0 4zog TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4WA9B 246 508 1130.0 AXI:69000 Type1 Inactive DFGout 13.311 10.281 None -75.93, 149.51 -77.88, -15.66 -59.19, 118.14 191.81, 69.86 106.96, -1.52 in-in in 7.643 Saltbr-in 2.056 HRD-out -116.7, 121.02 -81.78, -7.12 in-out-in SNCioi out-in ActLoopNT-out 5.327 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.35, 121.29 APE9-dihe-in -115.41, 155.9 APE8-dihe-in -66.84, 110.63 APE8-rot-na 32.52 APE67-dihe-in -70.78, -12.55 -43.03, -46.3 APE12-dist-na 18.5 APE11-dist-na 13.938 APE10-dist-na 17.498 APE9-dist-in 6.711 None None None XRAY 2.2 0.175 0.212 B 286 263 0 0 0 0 [[242, 495]] 1.0 4wa9 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3UE4A 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.471 10.087 None -73.57, 139.68 -129.47, 18.74 -70.04, -27.22 71.97, 85.11 -97.86, 45.9 in-out in 8.122 Saltbr-out 4.005 HRD-out -105.15, 128.48 -83.8, -2.91 out-out-in SNCooi out-in ActLoopNT-out 5.294 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 137.39 APE9-dihe-in -119.63, 157.7 APE8-dihe-in -69.93, 97.57 APE8-rot-na 25.4 APE67-dihe-in -65.99, -15.91 -45.97, -49.68 APE12-dist-na 19.211 APE11-dist-na 14.469 APE10-dist-na 17.122 APE9-dist-in 6.836 None None None XRAY 2.424 0.192 0.249 A 287 270 0 0 0 0 [[242, 495]] 1.0 3ue4 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
3UE4B 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.224 10.48 None -68.43, 143.68 -139.88, 24.33 -73.48, -36.67 65.16, 97.6 -93.69, 7.14 in-out in 8.491 Saltbr-out 3.771 HRD-in -88.28, -56.6 76.68, -0.41 out-out-in SNCooi out-in ActLoopNT-out 5.441 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.79, 122.21 APE9-dihe-in -108.43, 151.01 APE8-dihe-in -71.16, 105.45 APE8-rot-na 24.97 APE67-dihe-in -72.18, -12.67 -59.58, -44.17 APE12-dist-na 19.453 APE11-dist-na 14.748 APE10-dist-na 17.212 APE9-dist-in 6.892 None None None XRAY 2.424 0.192 0.249 B 287 268 2 0 0 0 [[242, 495]] 1.0 3ue4 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
8I7TA 232 500 1130.0 6I5:601 Type1.5_Back Inactive DFGout 13.264 11.956 None -62.98, 128.57 -72.85, -7.53 36.94, -135.32 264.95, 6.34 101.46, 15.06 in-in in 8.596 Saltbr-in 3.276 HRD-in -96.98, -47.23 68.77, 7.6 in-out-in SNCioi out-in ActLoopNT-out 5.853 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.95, 130.91 APE9-dihe-in -108.03, 159.47 APE8-dihe-in -73.45, 92.08 APE8-rot-na 23.57 APE67-dihe-in -76.01, -8.31 -52.5, -40.25 APE12-dist-na 19.734 APE11-dist-na 15.138 APE10-dist-na 18.068 APE9-dist-in 7.311 None PTR393 PTR393 XRAY 2.8 0.221 0.272 A 272 267 2 0 0 0 [[242, 495]] 1.0 8i7t TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2HZIB 233 500 1130.0 JIN:600 Type1.5_Back Inactive DFGout 12.651 10.8 None -64.82, 139.58 -123.5, 22.46 -72.33, 154.15 44.58, 70.92 81.45, -10.45 in-in in 8.048 Saltbr-in 2.788 HRD-in -103.52, -56.2 76.53, -2.92 in-out-in SNCioi out-in ActLoopNT-out 5.534 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.65, 133.63 APE9-dihe-in -122.59, 157.35 APE8-dihe-in -72.25, 93.6 APE8-rot-na 22.08 APE67-dihe-in -66.73, -17.62 -46.65, -45.74 APE12-dist-na 19.118 APE11-dist-na 14.407 APE10-dist-na 17.185 APE9-dist-in 6.795 None None None XRAY 1.7 0.177 0.204 B 277 264 4 0 0 0 [[242, 495]] 1.0 2hzi TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2G2HB 233 504 1130.0 P16:60532 Type1.5_Back Inactive DFGout 12.699 10.5 None -60.13, 139.26 -82.96, -16.55 -75.2, 165.15 55.98, 67.58 79.14, 12.62 in-out in 8.193 Saltbr-out 6.859 HRD-out -104.81, 126.85 -89.37, -5.07 out-out-in SNCooi out-in ActLoopNT-out 5.481 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.1, 135.12 APE9-dihe-in -121.36, 158.85 APE8-dihe-in -60.74, 105.18 APE8-rot-na 332.86 APE67-dihe-in -67.82, -12.38 -45.03, -49.81 APE12-dist-na 18.669 APE11-dist-na 13.902 APE10-dist-na 17.244 APE9-dist-in 6.55 H396P None None XRAY 2.0 0.194 0.213 B 287 272 0 0 0 0 [[242, 495]] 1.0 2g2h TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
2FO0A 46 511 1130.0 P16:60702 Type1.5_Back Inactive DFGout 13.447 11.785 None -76.52, 118.23 -95.45, 43.06 -89.94, 155.29 62.25, 72.76 62.2, 26.15 in-in in 8.055 Saltbr-in 3.154 HRD-in -101.49, -60.91 80.44, -3.96 in-out-in SNCioi out-in ActLoopNT-out 5.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.77, 155.96 APE9-dihe-in -130.48, 150.83 APE8-dihe-in -76.1, 87.73 APE8-rot-na 30.01 APE67-dihe-in -55.48, -20.39 -31.31, -58.23 APE12-dist-na 19.757 APE11-dist-na 15.052 APE10-dist-na 18.053 APE9-dist-in 7.226 D363N SEP50 SEP50 XRAY 2.27 0.21 0.246 A 495 466 0 0 0 0 [[242, 495]] 1.0 2fo0 TYR_ABL1_HUMAN TYR 5.5e-99 337.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
1OPLA 62 512 1130.0 P16:60539 Type1.5_Back Inactive DFGout 12.808 11.67 None -65.59, 134.14 -116.03, 33.28 -83.5, 159.91 53.21, 70.33 67.06, 8.01 in-in in 7.953 Saltbr-in 2.944 HRD-in -97.12, -53.99 73.72, -6.86 in-out-in SNCioi out-in ActLoopNT-out 5.553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.98, 127.83 APE9-dihe-in -117.56, 161.51 APE8-dihe-in -80.15, 93.03 APE8-rot-na 30.65 APE67-dihe-in -63.53, -19.0 -41.82, -48.43 APE12-dist-na 19.483 APE11-dist-na 14.757 APE10-dist-na 17.435 APE9-dist-in 7.125 K12R,D363N None None XRAY 3.42 0.306 0.315 A 537 451 0 0 0 0 [[242, 495]] 1.0 1opl TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
1OPLB 121 499 1130.0 P16:60538 Type1.5_Back Inactive DFGout 12.196 11.59 None -63.84, 141.4 -115.91, 33.22 -83.51, 160.0 53.06, 70.48 67.02, 7.94 in-in in 7.991 Saltbr-in 2.943 HRD-in -97.28, -53.9 73.81, -6.95 in-out-in SNCioi out-in ActLoopNT-out 5.553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.01, 127.73 APE9-dihe-in -117.46, 161.57 APE8-dihe-in -80.14, 92.99 APE8-rot-na 30.73 APE67-dihe-in -63.44, -19.12 -41.75, -48.48 APE12-dist-na 19.482 APE11-dist-na 14.757 APE10-dist-na 17.436 APE9-dist-in 7.125 K12R,D363N None None XRAY 3.42 0.306 0.315 B 537 365 0 0 0 0 [[242, 495]] 1.0 1opl TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
5MO4A 64 512 1130.0 NIL:60601,AY7:60602 Type2,Allosteric Inactive DFGout 13.947 11.318 None -138.43, -177.76 -149.4, 98.71 -92.55, 999.0 320.75, 134.82 999.0, 999.0 in-in in 8.106 Saltbr-in 2.797 HRD-in -66.66, -50.58 73.57, -12.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -49.47 APE8-dihe-out -61.4, -6.43 APE8-rot-na 335.89 APE67-dihe-in -62.17, -20.21 -56.07, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.098 None None None XRAY 2.17 0.184 0.217 A 495 429 20 0 0 18 [[242, 495]] 1.0 5mo4 TYR_ABL1_HUMAN TYR 1.1e-98 336.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
4WA9A 246 504 1130.0 AXI:69000 Type1 Inactive None 999.0 10.355 None -73.83, 149.34 -77.87, -21.14 -66.14, 121.84 190.75, 64.67 115.23, -11.12 none-none none 999.0 Saltbr-none 999.0 HRD-out -124.23, 124.72 -84.31, -3.72 none-out-in SNCnoi out-in ActLoopNT-out 5.409 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.89, 135.91 APE9-dihe-in -108.88, 156.35 APE8-dihe-in -71.91, 93.83 APE8-rot-na 24.22 APE67-dihe-in -74.38, -8.52 -49.97, -43.55 APE12-dist-na 18.561 APE11-dist-na 13.777 APE10-dist-na 16.661 APE9-dist-in 6.491 None None None XRAY 2.2 0.175 0.212 A 286 236 23 0 0 0 [[242, 495]] 1.0 4wa9 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

TYR_ABL1 (Tyrosine-protein kinase ABL1)

Total number of chains: 136
Active chains: 16
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 55 40.4% 3KFAA
DFGinter None 31 22.8% 2G2HA
DFGin BLAminus 21 15.4% AF-P00519-K1A
DFGout None 18 13.2% 2HZIA
DFGin BLBplus 6 4.4% 2G1TA
DFGinter BABtrans 3 2.2% 7W7XA
None None 2 1.5% 3DK7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL1_HUMAN 2HZ4C P00519 234 500 1130.0 4ST:501 Allosteric Active DFGin 7.109 13.517 BLAminus -106.9, 179.4 68.82, 76.0 -90.83, 7.94 295.39, 93.15 -43.83, -23.1 in-in in 7.878 Saltbr-in 2.737 HRD-in -90.54, -43.68 68.76, 3.22 in-in-in SNCiii in-in ActLoopNT-in 3.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.98, 153.91 APE9-dihe-in -143.05, 161.74 APE8-dihe-in -62.63, 109.18 APE8-rot-na 10.02 APE67-dihe-in -54.86, -29.12 -56.69, -54.75 APE12-dist-na 14.951 APE11-dist-na 10.157 APE10-dist-na 13.134 APE9-dist-in 7.41 None None None XRAY 2.8 0.22 0.285 C 273 259 8 0 0 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7N9GB P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.754 13.445 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.807 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.041 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.951 APE11-dist-na 10.121 APE10-dist-na 12.279 APE9-dist-in 7.137 None None None XRAY 2.2 0.219 0.251 B 271 264 2 0 0 0 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN AF-P00519-K1A P00519 234 503 1130.0 No_ligand No_ligand Active DFGin 6.679 13.681 BLAminus -121.82, -148.36 27.66, 69.52 -83.21, 16.04 300.66, 100.42 -58.22, -38.59 in-in in 7.98 Saltbr-in 2.679 HRD-in -80.76, -46.58 69.6, -13.75 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.75, 141.7 APE9-dihe-in -129.36, 153.57 APE8-dihe-in -68.2, 94.98 APE8-rot-na 29.24 APE67-dihe-in -68.16, -17.51 -48.71, -43.64 APE12-dist-na 14.792 APE11-dist-na 9.969 APE10-dist-na 12.408 APE9-dist-in 6.952 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[242, 495]] 1.0 AF-P00519-K1 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN AF-P00519-K3A P00519 234 503 1130.0 No_ligand No_ligand Active DFGin 6.361 13.579 BLAminus -138.26, -173.5 60.01, 57.15 -76.49, 13.27 303.75, 99.33 -58.39, -34.06 in-in in 7.815 Saltbr-in 2.755 HRD-in -85.57, -49.18 70.08, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.986 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.76, 136.34 APE9-dihe-in -128.76, 153.96 APE8-dihe-in -76.2, 91.75 APE8-rot-na 33.55 APE67-dihe-in -64.39, -24.25 -44.48, -44.47 APE12-dist-na 14.635 APE11-dist-na 9.825 APE10-dist-na 11.728 APE9-dist-in 6.601 None None None AF2 -1.0 1.0 1.0 A 270 270 0 0 0 0 [[242, 495]] 1.0 AF-P00519-K3 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4TWPA P00519 233 503 1130.0 AXI:601 Type1 Active DFGin 6.826 13.373 BLAminus -126.1, -169.4 57.38, 73.68 -93.34, 9.79 307.92, 111.58 -48.96, -36.81 in-in in 7.981 Saltbr-in 2.446 HRD-in -95.85, -58.6 83.7, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.5, 146.64 APE9-dihe-in -124.84, 163.92 APE8-dihe-in -72.62, 90.26 APE8-rot-na 28.03 APE67-dihe-in -71.19, -17.43 -45.75, -44.99 APE12-dist-na 14.989 APE11-dist-na 10.195 APE10-dist-na 13.212 APE9-dist-in 7.168 T315I None None XRAY 2.4 0.213 0.241 A 271 266 5 0 0 0 [[242, 495]] 1.0 4twp Homo sapiens TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4TWPB P00519 233 503 1130.0 AXI:601 Type1 Active DFGin 6.728 13.117 BLAminus -138.14, -168.47 59.67, 66.52 -88.52, 8.05 307.93, 102.65 -49.29, -39.91 in-in in 7.772 Saltbr-in 2.648 HRD-in -82.31, -50.76 78.18, -18.83 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.57, 120.03 APE9-dihe-in -116.59, 156.81 APE8-dihe-in -66.81, 119.12 APE8-rot-na 347.15 APE67-dihe-in -70.99, -21.45 -67.92, -38.41 APE12-dist-na 15.208 APE11-dist-na 10.654 APE10-dist-na 13.036 APE9-dist-in 6.848 T315I None None XRAY 2.4 0.213 0.241 B 271 271 0 0 0 0 [[242, 495]] 1.0 4twp Homo sapiens TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2V7AA P00519 233 503 1130.0 627:1504 Type1 Active DFGin 6.894 14.16 BLAminus -145.06, -170.76 64.01, 66.73 -92.57, 17.46 295.88, 104.37 -56.64, -27.12 in-in in 7.782 Saltbr-in 2.519 HRD-in -93.72, -56.9 83.27, 8.16 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.69, 132.9 APE9-dihe-in -115.95, 155.97 APE8-dihe-in -67.28, 120.19 APE8-rot-na 16.95 APE67-dihe-in -81.75, -3.2 -58.95, -43.12 APE12-dist-na 14.866 APE11-dist-na 10.223 APE10-dist-na 13.016 APE9-dist-in 6.841 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 A 286 271 0 0 0 0 [[242, 495]] 1.0 2v7a Homo sapiens TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2V7AB P00519 234 503 1130.0 627:1504 Type1 Active DFGin 6.904 13.955 BLAminus -120.25, -166.43 59.68, 67.6 -85.2, 11.1 297.73, 106.5 -52.29, -48.72 in-in in 7.535 Saltbr-in 2.696 HRD-in -95.53, -42.9 77.78, -18.98 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.95, 149.39 APE9-dihe-in -131.37, 144.36 APE8-dihe-in -64.58, 88.08 APE8-rot-na 22.1 APE67-dihe-in -78.01, -10.87 -49.77, -37.43 APE12-dist-na 14.954 APE11-dist-na 10.309 APE10-dist-na 13.12 APE9-dist-in 7.359 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 B 286 270 0 0 0 0 [[242, 495]] 1.0 2v7a Homo sapiens TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HZ4B P00519 233 498 1130.0 4ST:501 Type1 Active DFGin 6.781 12.906 BLAminus -136.29, 178.03 62.62, 92.29 -99.12, 17.06 306.64, 102.22 -49.71, -38.7 in-in in 8.114 Saltbr-in 2.713 HRD-in -96.51, -47.12 66.31, -5.28 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.77, 139.94 APE9-dihe-in -124.12, 153.4 APE8-dihe-in -60.98, 117.48 APE8-rot-na 25.18 APE67-dihe-in -77.16, -10.29 -56.55, -40.66 APE12-dist-na 14.733 APE11-dist-na 10.004 APE10-dist-na 12.996 APE9-dist-in 7.129 None None None XRAY 2.8 0.22 0.285 B 273 261 5 0 0 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2F4JA P00519 227 513 1130.0 VX6:514 Type1 Active DFGin 6.831 13.63 BLAminus -139.09, -163.86 46.92, 83.86 -101.63, 25.32 309.5, 96.14 -54.55, -28.15 in-in in 8.08 Saltbr-in 2.583 HRD-in -88.91, -46.94 72.68, 7.25 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.54, 142.96 APE9-dihe-in -128.46, 161.87 APE8-dihe-in -67.39, 90.98 APE8-rot-na 332.91 APE67-dihe-in -62.36, -25.51 -37.57, -50.75 APE12-dist-na 15.236 APE11-dist-na 10.443 APE10-dist-na 13.086 APE9-dist-in 7.322 H396P None None XRAY 1.91 0.207 0.239 A 287 287 0 0 0 0 [[242, 495]] 1.0 2f4j Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2GQGB P00519 229 499 1130.0 1N1:60502 Type1.5_Back Active DFGin 6.725 13.407 BLAminus -132.96, -163.46 57.81, 75.2 -98.78, 6.6 302.62, 104.4 -52.45, -32.74 in-in in 8.034 Saltbr-in 2.899 HRD-in -101.91, -48.31 65.85, 10.15 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.98, 171.69 APE9-dihe-in -137.71, 138.65 APE8-dihe-in -58.61, 114.78 APE8-rot-na 30.65 APE67-dihe-in -71.5, -8.45 -53.53, -44.9 APE12-dist-na 11.258 APE11-dist-na 7.468 APE10-dist-na 11.641 APE9-dist-in 6.276 None PTR393 PTR393 XRAY 2.4 0.208 0.273 B 278 271 0 0 0 0 [[242, 495]] 1.0 2gqg Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G2IA P00519 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.631 13.433 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.005 Saltbr-in 3.247 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.904 APE11-dist-na 10.573 APE10-dist-na 12.836 APE9-dist-in 7.31 H396P None None XRAY 3.12 0.251 0.308 A 287 271 3 0 0 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G2IB P00519 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.623 13.745 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.795 Saltbr-in 2.872 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.404 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.975 APE11-dist-na 10.34 APE10-dist-na 12.829 APE9-dist-in 7.625 H396P None None XRAY 3.12 0.251 0.308 B 287 265 4 0 0 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HZ4A P00519 234 500 1130.0 4ST:501 Allosteric Inactive DFGin 6.899 13.314 BLAminus -141.07, -179.05 61.44, 74.68 -93.23, 11.06 298.48, 103.02 -47.37, -45.58 in-out in 8.043 Saltbr-out 4.199 HRD-in -73.48, -44.6 66.11, 2.51 out-in-in SNCoii in-in ActLoopNT-in 3.136 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.55, 127.23 APE9-dihe-in -112.0, 154.72 APE8-dihe-in -73.75, 92.13 APE8-rot-na 28.06 APE67-dihe-in -62.73, -9.15 -43.63, -56.72 APE12-dist-na 15.433 APE11-dist-na 10.608 APE10-dist-na 12.472 APE9-dist-in 7.423 None None None XRAY 2.8 0.22 0.285 A 273 262 5 0 0 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6XR6A P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGin 6.202 12.576 BLAminus -139.61, -169.12 45.42, 85.51 -100.09, 27.27 299.51, 89.83 -59.45, -29.58 in-in in 8.365 Saltbr-in 2.779 HRD-in -105.48, -39.35 69.66, 6.23 in-out-in SNCioi out-in ActLoopNT-out 3.955 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.77, 106.46 APE9-dihe-in -100.35, 127.3 APE8-dihe-in -74.27, 111.44 APE8-rot-na 29.98 APE67-dihe-in -67.49, -13.13 -54.87, -37.15 APE12-dist-na 11.902 APE11-dist-na 11.413 APE10-dist-na 7.638 APE9-dist-in 4.653 None None None NMR 999.0 999.0 999.0 A 287 287 0 0 0 0 [[242, 495]] 1.0 6xr6 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2GQGA P00519 229 500 1130.0 1N1:60501 Type1 Inactive DFGin 6.637 14.039 BLAminus -125.87, -162.48 50.1, 80.24 -101.91, 13.59 304.08, 105.04 -55.58, -28.07 in-in in 8.206 Saltbr-in 3.337 HRD-in -94.17, -46.19 69.1, 8.59 in-in-out SNCiio in-out ActLoopNT-in 3.089 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.45, -178.77 APE9-dihe-in -144.75, 146.99 APE8-dihe-in -51.41, 101.22 APE8-rot-na 30.18 APE67-dihe-in -72.33, -8.18 -47.68, -48.27 APE12-dist-na 13.807 APE11-dist-na 10.155 APE10-dist-na 13.162 APE9-dist-in 7.017 None PTR393 PTR393 XRAY 2.4 0.208 0.273 A 278 272 0 0 0 0 [[242, 495]] 1.0 2gqg Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8SSNB P00519 64 506 1130.0 AY7:60601,SKI:60602 Allosteric,Type1 Inactive DFGin 4.807 13.65 BLBplus -122.3, -177.61 58.55, 39.13 -103.24, 130.77 75.83, 117.96 81.37, 999.0 out-out out 13.62 Saltbr-out 14.026 HRD-in -82.83, -50.46 68.17, -10.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 11.09 APE8-rot-na 31.53 APE67-dihe-in -79.53, -5.66 -99.34, -42.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 B 448 385 51 0 0 18 [[242, 495]] 1.0 8ssn Homo sapiens TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8SSNA P00519 64 507 1130.0 AY7:60601,SKI:60602 Allosteric,Type1.5_Back Inactive DFGin 5.429 12.696 BLBplus -123.62, -174.23 61.42, 33.23 -93.01, 133.21 53.71, 95.25 73.81, 0.97 out-out out 14.038 Saltbr-out 13.989 HRD-in -74.8, -57.17 85.55, -3.37 out-out-none SNCoon out-none ActLoopNT-out 10.264 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.56 APE8-rot-na 17.66 APE67-dihe-in -74.03, -24.85 -108.88, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 A 448 419 16 0 0 11 [[242, 495]] 1.0 8ssn Homo sapiens TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G1TA P00519 232 502 1130.0 No_ligand No_ligand Inactive DFGin 5.489 13.359 BLBplus -129.52, 174.85 49.7, 38.76 -72.97, 132.27 38.5, 86.98 68.27, 5.02 out-out out 14.394 Saltbr-out 14.447 HRD-in -72.65, -55.09 74.07, -6.35 out-out-out SNCooo out-out ActLoopNT-out 7.333 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -93.21, 127.41 APE9-dihe-in -142.61, 161.69 APE8-dihe-in -90.21, 73.8 APE8-rot-na 25.96 APE67-dihe-in -72.87, -5.55 -36.53, -50.03 APE12-dist-na 21.695 APE11-dist-na 17.127 APE10-dist-na 15.501 APE9-dist-out 8.503 None None None XRAY 1.8 0.221 0.244 A 287 271 0 0 0 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G1TB P00519 230 502 1130.0 No_ligand No_ligand Inactive DFGin 5.613 13.461 BLBplus -123.19, 174.0 52.07, 35.11 -71.07, 127.0 40.58, 89.58 70.82, 9.16 out-out out 14.502 Saltbr-out 14.408 HRD-in -70.85, -56.38 81.24, -19.54 out-out-out SNCooo out-out ActLoopNT-out 7.337 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.93, 136.77 APE9-dihe-in -145.05, 161.95 APE8-dihe-in -89.74, 74.17 APE8-rot-na 33.06 APE67-dihe-in -70.55, -3.76 -28.93, -56.54 APE12-dist-na 21.369 APE11-dist-na 16.867 APE10-dist-na 15.526 APE9-dist-out 8.271 None None None XRAY 1.8 0.221 0.244 B 287 273 0 0 0 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G1TC P00519 232 507 1130.0 No_ligand No_ligand Inactive DFGin 5.394 13.548 BLBplus -120.72, 170.38 50.85, 37.0 -72.09, 126.35 41.53, 90.26 72.34, 10.44 out-out out 14.665 Saltbr-out 14.686 HRD-in -71.51, -57.81 80.53, -13.86 out-out-out SNCooo out-out ActLoopNT-out 7.398 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -104.53, 132.88 APE9-dihe-in -148.89, 164.58 APE8-dihe-in -86.44, 74.64 APE8-rot-na 29.85 APE67-dihe-in -67.97, -5.39 -28.15, -57.51 APE12-dist-na 21.355 APE11-dist-na 16.893 APE10-dist-na 15.469 APE9-dist-out 8.181 None None None XRAY 1.8 0.221 0.244 C 287 276 0 0 0 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G1TD P00519 229 502 1130.0 No_ligand No_ligand Inactive DFGin 5.724 13.491 BLBplus -127.26, 170.73 53.33, 36.32 -70.41, 128.95 38.1, 89.88 67.15, 13.72 out-out out 14.759 Saltbr-out 14.479 HRD-in -69.96, -57.67 85.75, -24.63 out-out-out SNCooo out-out ActLoopNT-out 7.336 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.18, 134.49 APE9-dihe-in -146.03, 159.07 APE8-dihe-in -86.2, 75.17 APE8-rot-na 27.48 APE67-dihe-in -64.32, -8.55 -32.05, -58.59 APE12-dist-na 20.938 APE11-dist-na 16.469 APE10-dist-na 15.423 APE9-dist-out 8.521 None None None XRAY 1.8 0.221 0.244 D 287 274 0 0 0 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7W7XA P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.558 7.786 BABtrans -66.93, 131.45 -122.59, 21.38 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.665 Saltbr-out 7.93 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.828 APE11-dist-na 15.129 APE10-dist-na 17.953 APE9-dist-in 7.347 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272 267 2 0 0 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7W7XB P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.845 8.188 BABtrans -65.38, 135.53 -123.74, 24.69 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.036 Saltbr-out 8.33 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.562 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.996 APE10-dist-na 17.134 APE9-dist-in 6.992 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272 264 5 0 0 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.001 8.022 BABtrans -71.04, 121.63 -84.68, 7.52 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.643 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.422 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.56 APE11-dist-na 13.923 APE10-dist-na 16.549 APE9-dist-in 6.428 None None None XRAY 2.891 0.232 0.259 B 408 359 9 0 0 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.421 8.187 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.878 Saltbr-out 9.786 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.544 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.85 None None None XRAY 2.2 0.219 0.251 A 271 250 16 0 0 13 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.762 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.439 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.891 None None None XRAY 2.2 0.219 0.251 C 271 233 33 0 0 5 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G2FA P00519 232 506 1130.0 No_ligand No_ligand Inactive DFGinter 9.904 7.215 None -62.11, 127.98 -87.38, -14.52 -64.34, -9.9 184.11, 68.76 -103.31, 15.09 in-out in 8.923 Saltbr-out 8.97 HRD-out -103.65, 121.34 -60.45, -26.89 out-out-in SNCooi out-in ActLoopNT-out 5.537 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.48, 145.14 APE9-dihe-in -132.2, 154.35 APE8-dihe-in -76.87, 87.18 APE8-rot-na 28.49 APE67-dihe-in -66.0, -4.27 -34.28, -57.53 APE12-dist-na 21.406 APE11-dist-na 16.576 APE10-dist-na 17.867 APE9-dist-in 7.431 H396P None None XRAY 2.7 0.234 0.286 A 287 275 0 0 0 0 [[242, 495]] 1.0 2g2f Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6BL8A P00519 233 502 1130.0 PVB:601 Type1 Inactive DFGinter 8.638 5.129 None -71.96, 143.85 -136.17, 39.9 -72.13, -37.4 288.6, 104.47 -92.65, 14.81 in-out in 8.634 Saltbr-out 7.155 HRD-in -90.04, -55.84 74.1, 2.35 out-out-in SNCooi out-in ActLoopNT-out 5.726 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.55, 128.85 APE9-dihe-in -120.75, 157.5 APE8-dihe-in -76.2, 98.23 APE8-rot-na 22.7 APE67-dihe-in -70.51, -5.85 -42.21, -49.52 APE12-dist-na 19.841 APE11-dist-na 15.131 APE10-dist-na 17.437 APE9-dist-in 7.088 None None None XRAY 2.5 0.177 0.204 A 272 270 0 0 0 0 [[242, 495]] 1.0 6bl8 Homo sapiens TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6BL8B P00519 233 504 1130.0 PVB:601 Type1 Inactive DFGinter 8.616 5.229 None -71.73, 142.55 -134.64, 39.69 -72.51, -38.46 288.36, 104.6 -92.85, 14.3 in-none in 8.487 Saltbr-none 999.0 HRD-in -91.59, -53.55 75.4, -2.02 none-out-in SNCnoi out-in ActLoopNT-out 5.421 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.94, 127.06 APE9-dihe-in -119.46, 155.16 APE8-dihe-in -72.29, 100.21 APE8-rot-na 22.45 APE67-dihe-in -69.04, -6.83 -41.1, -50.73 APE12-dist-na 19.223 APE11-dist-na 14.504 APE10-dist-na 17.351 APE9-dist-in 6.845 None None None XRAY 2.5 0.177 0.204 B 272 268 4 0 0 1 [[242, 495]] 1.0 6bl8 Homo sapiens TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8I7SA P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 9.134 7.631 None -67.26, 134.08 -124.25, 38.37 -90.11, -15.51 320.43, 108.35 -104.88, 9.69 in-in in 8.711 Saltbr-in 2.997 HRD-in -101.62, -50.5 73.92, -2.89 in-out-in SNCioi out-in ActLoopNT-out 5.643 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.21, 132.08 APE9-dihe-in -105.71, 156.86 APE8-dihe-in -74.32, 88.38 APE8-rot-na 26.42 APE67-dihe-in -74.59, -6.02 -50.76, -44.43 APE12-dist-na 19.815 APE11-dist-na 15.13 APE10-dist-na 17.859 APE9-dist-in 7.511 None PTR393 PTR393 XRAY 1.946 0.186 0.216 A 272 262 7 0 0 0 [[242, 495]] 1.0 8i7s Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8I7SB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.73 7.672 None -65.46, 135.7 -123.29, 38.43 -94.21, -15.86 318.08, 102.31 -104.7, 7.72 in-out in 8.739 Saltbr-out 4.579 HRD-in -100.98, -46.35 75.57, -9.9 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.26, 135.01 APE9-dihe-in -100.5, 152.85 APE8-dihe-in -79.3, 86.45 APE8-rot-na 26.11 APE67-dihe-in -72.94, -9.36 -50.77, -43.49 APE12-dist-na 18.49 APE11-dist-na 13.88 APE10-dist-na 16.57 APE9-dist-in 7.198 None PTR393 PTR393 XRAY 1.946 0.186 0.216 B 272 264 5 0 0 0 [[242, 495]] 1.0 8i7s Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8I7ZB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.467 7.129 None -66.85, 127.11 -111.9, 44.88 -97.85, -10.98 300.72, 89.67 -118.62, 22.53 in-in in 8.811 Saltbr-in 3.079 HRD-in -103.27, -34.43 69.06, -16.77 in-out-in SNCioi out-in ActLoopNT-out 5.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.59, 128.54 APE9-dihe-in -113.43, 144.92 APE8-dihe-in -66.08, 92.18 APE8-rot-na 22.51 APE67-dihe-in -69.32, -14.4 -51.28, -44.78 APE12-dist-na 18.584 APE11-dist-na 13.952 APE10-dist-na 16.689 APE9-dist-in 6.907 None PTR393 PTR393 XRAY 2.255 0.177 0.213 B 272 265 4 0 0 0 [[242, 495]] 1.0 8i7z Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7W7YA P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.383 7.452 None -61.0, 140.15 -123.07, 7.15 -97.99, -19.69 299.86, 99.82 -107.54, 26.38 in-out in 7.832 Saltbr-out 4.324 HRD-in -95.67, -53.61 79.5, -5.33 out-out-in SNCooi out-in ActLoopNT-out 5.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.53, 135.86 APE9-dihe-in -112.22, 154.02 APE8-dihe-in -72.0, 92.74 APE8-rot-na 26.94 APE67-dihe-in -71.4, -8.88 -51.03, -45.88 APE12-dist-na 19.642 APE11-dist-na 14.989 APE10-dist-na 18.032 APE9-dist-in 7.453 None PTR393 PTR393 XRAY 2.2 0.176 0.201 A 276 269 0 0 0 0 [[242, 495]] 1.0 7w7y Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7W7YB P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.706 7.939 None -67.02, 132.31 -125.55, 45.99 -104.04, 122.68 325.21, 94.33 94.56, 12.27 in-out in 9.12 Saltbr-out 4.526 HRD-in -107.75, -54.39 71.9, 2.12 out-out-in SNCooi out-in ActLoopNT-out 5.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.81, 139.55 APE9-dihe-in -122.0, 156.17 APE8-dihe-in -66.34, 94.72 APE8-rot-na 24.45 APE67-dihe-in -67.89, -13.14 -48.19, -46.95 APE12-dist-na 18.655 APE11-dist-na 14.121 APE10-dist-na 17.512 APE9-dist-in 7.157 None PTR393 PTR393 XRAY 2.2 0.176 0.201 B 276 267 2 0 0 0 [[242, 495]] 1.0 7w7y Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8H7FA P00519 232 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.439 7.331 None -69.17, 127.91 -123.7, 53.27 -97.59, -18.49 298.04, 92.12 -115.41, 32.43 in-none in 7.913 Saltbr-none 999.0 HRD-in -98.47, -51.88 73.34, 1.6 none-out-in SNCnoi out-in ActLoopNT-out 5.774 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.81, 130.64 APE9-dihe-in -111.12, 149.71 APE8-dihe-in -68.85, 91.65 APE8-rot-na 24.28 APE67-dihe-in -80.23, -2.27 -54.19, -39.54 APE12-dist-na 19.803 APE11-dist-na 15.167 APE10-dist-na 17.763 APE9-dist-in 7.415 None PTR393 PTR393 XRAY 2.45 0.206 0.234 A 277 267 2 0 0 0 [[242, 495]] 1.0 8h7f Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8H7FB P00519 233 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.625 7.629 None -66.82, 132.57 -128.02, 53.13 -102.99, -16.57 308.49, 91.71 -113.57, 28.76 in-none in 8.398 Saltbr-none 999.0 HRD-out -118.2, 104.8 -89.8, 17.52 none-out-in SNCnoi out-in ActLoopNT-out 5.639 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.35, 131.94 APE9-dihe-in -101.32, 145.24 APE8-dihe-in -82.14, 94.32 APE8-rot-na 25.72 APE67-dihe-in -72.86, -15.28 -51.55, -45.38 APE12-dist-na 18.504 APE11-dist-na 13.782 APE10-dist-na 16.382 APE9-dist-in 7.368 None PTR393 PTR393 XRAY 2.45 0.206 0.234 B 277 257 11 0 0 0 [[242, 495]] 1.0 8h7f Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8H7HA P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.39 7.687 None -66.88, 126.67 -122.6, 45.68 -99.68, -4.7 302.75, 91.96 -123.88, 23.24 in-none in 8.036 Saltbr-none 999.0 HRD-in -99.74, -50.53 75.81, -4.43 none-out-in SNCnoi out-in ActLoopNT-out 5.704 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.51, 132.84 APE9-dihe-in -111.46, 154.74 APE8-dihe-in -71.0, 89.59 APE8-rot-na 25.0 APE67-dihe-in -73.93, -5.32 -52.54, -45.5 APE12-dist-na 19.749 APE11-dist-na 15.182 APE10-dist-na 18.067 APE9-dist-in 7.438 None PTR393 PTR393 XRAY 2.278 0.185 0.221 A 277 269 0 0 0 0 [[242, 495]] 1.0 8h7h Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8H7HB P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.489 7.865 None -64.21, 134.18 -129.36, 51.05 -106.57, -14.6 307.18, 95.7 -114.91, 23.11 in-none in 8.74 Saltbr-none 999.0 HRD-in -105.06, -54.2 71.08, 0.92 none-out-in SNCnoi out-in ActLoopNT-out 5.593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.95, 127.69 APE9-dihe-in -114.73, 145.44 APE8-dihe-in -67.21, 95.26 APE8-rot-na 23.35 APE67-dihe-in -67.71, -18.52 -54.95, -42.72 APE12-dist-na 18.697 APE11-dist-na 13.937 APE10-dist-na 16.449 APE9-dist-in 6.698 None PTR393 PTR393 XRAY 2.278 0.185 0.221 B 277 258 11 0 0 0 [[242, 495]] 1.0 8h7h Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4ZOGA P00519 233 501 1130.0 VX6:601 Type1 Inactive DFGinter 9.034 8.188 None -67.97, 132.1 -127.82, 25.62 -66.74, -66.47 163.98, 49.73 -79.37, 45.35 out-out out 10.975 Saltbr-out 6.767 HRD-out -91.32, 151.74 -125.52, 16.46 out-out-in SNCooi out-in ActLoopNT-out 5.502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.42, 138.31 APE9-dihe-in -118.45, 160.42 APE8-dihe-in -78.39, 96.94 APE8-rot-na 30.14 APE67-dihe-in -71.46, -10.56 -52.82, -45.85 APE12-dist-na 19.808 APE11-dist-na 15.163 APE10-dist-na 17.423 APE9-dist-in 7.144 None None None XRAY 2.3 0.187 0.233 A 283 269 0 0 0 0 [[242, 495]] 1.0 4zog Homo sapiens TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7CC2A P00519 233 501 1130.0 FVC:601 Type1 Inactive DFGinter 9.165 8.258 None -73.32, 112.44 -109.3, 64.01 -105.28, -20.44 309.47, 116.75 -109.01, 28.74 out-out out 11.085 Saltbr-out 8.369 HRD-in -90.34, -46.17 72.58, 0.36 out-out-in SNCooi out-in ActLoopNT-out 5.617 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.21, 129.2 APE9-dihe-in -111.79, 156.63 APE8-dihe-in -66.39, 106.43 APE8-rot-na 344.92 APE67-dihe-in -73.87, -6.7 -58.13, -47.58 APE12-dist-na 19.252 APE11-dist-na 14.472 APE10-dist-na 17.321 APE9-dist-in 6.862 None None None XRAY 2.723 0.196 0.242 A 310 263 6 0 0 0 [[242, 495]] 1.0 7cc2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7CC2B P00519 232 501 1130.0 FVC:601 Type1 Inactive DFGinter 8.979 8.607 None -71.77, 114.13 -110.49, 61.26 -109.45, -24.12 312.83, 116.95 -111.64, 29.87 in-none in 9.541 Saltbr-none 999.0 HRD-in -88.51, -47.46 71.59, 1.41 none-out-in SNCnoi out-in ActLoopNT-out 5.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.35, 131.77 APE9-dihe-in -108.11, 154.53 APE8-dihe-in -67.24, 106.75 APE8-rot-na 21.35 APE67-dihe-in -74.13, -7.58 -57.65, -47.12 APE12-dist-na 19.108 APE11-dist-na 14.389 APE10-dist-na 17.586 APE9-dist-in 7.008 None None None XRAY 2.723 0.196 0.242 B 310 266 4 0 0 0 [[242, 495]] 1.0 7cc2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7DT2A P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.472 7.396 None -67.36, 135.71 -126.94, 46.3 -101.94, -14.95 304.55, 98.79 -112.2, 27.67 in-out in 9.0 Saltbr-out 3.798 HRD-in -98.03, -51.7 81.6, -7.87 out-out-in SNCooi out-in ActLoopNT-out 5.749 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.44, 133.63 APE9-dihe-in -118.19, 150.76 APE8-dihe-in -62.24, 99.73 APE8-rot-na 22.52 APE67-dihe-in -73.29, -7.91 -58.82, -45.37 APE12-dist-na 19.606 APE11-dist-na 14.956 APE10-dist-na 17.818 APE9-dist-in 7.259 None None None XRAY 2.3 0.208 0.237 A 310 265 3 0 0 0 [[242, 495]] 1.0 7dt2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 7DT2B P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.633 7.853 None -67.09, 137.47 -125.9, 46.84 -103.12, -16.04 307.9, 99.91 -112.15, 26.28 in-out in 9.594 Saltbr-out 4.084 HRD-in -96.99, -47.74 84.36, -13.26 out-out-in SNCooi out-in ActLoopNT-out 5.563 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.22, 136.31 APE9-dihe-in -118.25, 150.94 APE8-dihe-in -59.92, 103.33 APE8-rot-na 21.91 APE67-dihe-in -72.55, -10.92 -57.38, -43.07 APE12-dist-na 18.628 APE11-dist-na 13.965 APE10-dist-na 17.355 APE9-dist-in 6.665 None None None XRAY 2.3 0.208 0.237 B 310 267 1 0 0 0 [[242, 495]] 1.0 7dt2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G2HA P00519 233 504 1130.0 P16:60532 Type1 Inactive DFGinter 10.338 7.763 None -69.8, 139.79 -117.08, 21.66 -74.78, -30.76 182.98, 70.09 -83.63, 27.99 in-out in 8.947 Saltbr-out 8.475 HRD-out -106.09, 125.25 -68.95, -15.96 out-out-in SNCooi out-in ActLoopNT-out 5.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.55, 116.51 APE9-dihe-in -118.82, 162.2 APE8-dihe-in -67.24, 92.86 APE8-rot-na 32.82 APE67-dihe-in -70.58, -6.79 -39.4, -50.98 APE12-dist-na 19.946 APE11-dist-na 15.235 APE10-dist-na 17.204 APE9-dist-in 6.534 H396P None None XRAY 2.0 0.194 0.213 A 287 272 0 0 0 0 [[242, 495]] 1.0 2g2h Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4XEYA P00519 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.927 None -70.89, 123.51 -90.91, 18.27 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.948 Saltbr-out 8.69 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.73 APE11-dist-na 14.108 APE10-dist-na 16.542 APE9-dist-in 6.588 None None None XRAY 2.891 0.232 0.259 A 408 269 4 0 0 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8I7ZA P00519 232 499 1130.0 6CI:601,BAL:602 Type1,Type1 Inactive DFGinter 8.675 7.469 None -68.15, 124.34 -115.26, 44.89 -92.28, -20.89 299.64, 92.88 -113.55, 33.09 in-none in 9.013 Saltbr-none 999.0 HRD-in -101.45, -51.38 75.46, -1.93 none-out-in SNCnoi out-in ActLoopNT-out 5.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.91, 129.83 APE9-dihe-in -107.25, 158.29 APE8-dihe-in -77.21, 88.15 APE8-rot-na 26.6 APE67-dihe-in -78.48, -3.49 -49.13, -44.82 APE12-dist-na 19.991 APE11-dist-na 15.346 APE10-dist-na 18.074 APE9-dist-in 7.513 None PTR393 PTR393 XRAY 2.255 0.177 0.213 A 272 258 10 0 0 0 [[242, 495]] 1.0 8i7z Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4YC8A P00519 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.254 9.479 None -68.71, 128.66 -122.3, 46.03 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.142 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.44 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.127 APE11-dist-na 14.45 APE10-dist-na 17.471 APE9-dist-in 6.747 None None None XRAY 2.9 0.199 0.24 A 287 259 10 0 0 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4YC8B P00519 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.555 9.692 None -74.12, 129.26 -121.25, 39.81 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.822 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.669 APE11-dist-na 14.989 APE10-dist-na 17.785 APE9-dist-in 6.93 None None None XRAY 2.9 0.199 0.24 B 287 264 6 0 0 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 9KS5A P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.73 5.596 None -72.67, 142.35 -137.94, 44.53 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.005 Saltbr-na 6.545 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.819 APE11-dist-na 15.248 APE10-dist-na 18.1 APE9-dist-in 7.545 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272 267 1 0 0 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 9KS5B P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.971 5.847 None -69.26, 149.18 -127.32, 25.05 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.96 Saltbr-na 6.29 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.464 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.424 APE11-dist-na 14.058 APE10-dist-na 17.265 APE9-dist-in 6.892 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272 268 0 0 0 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6XRGA P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.006 8.697 BBAminus -171.83, 165.33 -155.54, 133.54 -84.4, -28.08 302.76, 128.31 104.78, 35.25 in-in in 8.063 Saltbr-in 3.14 HRD-in -67.57, -50.13 76.12, -27.45 in-out-out SNCioo out-out ActLoopNT-out 18.414 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -124.03, 17.56 APE9-dihe-in -95.78, 148.38 APE8-dihe-in -59.62, 96.75 APE8-rot-na 336.69 APE67-dihe-in -65.49, -36.89 -72.8, -27.02 APE12-dist-na 14.4 APE11-dist-na 13.457 APE10-dist-na 9.211 APE9-dist-in 6.36 G250E,M290L,T389Y None None NMR 999.0 999.0 999.0 A 287 287 0 0 0 0 [[242, 495]] 1.0 6xrg Homo sapiens TYR_ABL1_HUMAN TYR 1.3e-100 341.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3QRJA P00519 234 496 1130.0 919:2 Type2 Inactive DFGout 13.149 8.99 BBAminus -140.1, 177.46 -140.75, 104.13 -86.94, 4.73 283.88, 85.78 63.32, 48.64 in-in in 7.673 Saltbr-in 2.775 HRD-in -79.02, -49.06 80.26, -14.09 in-out-in SNCioi out-in ActLoopNT-out 14.988 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.38, 130.47 APE9-dihe-in -139.16, 150.69 APE8-dihe-in -78.39, 79.63 APE8-rot-na 34.62 APE67-dihe-in -72.48, -9.29 -46.12, -53.19 APE12-dist-na 18.622 APE11-dist-na 15.645 APE10-dist-na 10.845 APE9-dist-in 7.358 T315I None None XRAY 1.82 0.232 0.286 A 277 258 5 0 0 0 [[242, 495]] 1.0 3qrj Homo sapiens TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3QRJB P00519 233 497 1130.0 919:1 Type2 Inactive DFGout 13.129 9.079 BBAminus -139.41, 169.11 -133.48, 106.22 -82.14, 0.45 283.14, 89.48 61.09, 48.15 in-in in 7.931 Saltbr-in 2.795 HRD-in -78.78, -56.83 82.44, -6.52 in-out-in SNCioi out-in ActLoopNT-out 15.105 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.29, 121.26 APE9-dihe-in -134.93, 153.91 APE8-dihe-in -77.7, 85.51 APE8-rot-na 33.76 APE67-dihe-in -63.53, -18.09 -55.44, -46.47 APE12-dist-na 18.656 APE11-dist-na 15.376 APE10-dist-na 10.823 APE9-dist-in 7.722 T315I None None XRAY 1.82 0.232 0.286 B 277 265 0 0 0 0 [[242, 495]] 1.0 3qrj Homo sapiens TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HZ0A P00519 233 497 1130.0 GIN:600 Type2 Inactive DFGout 16.315 10.475 BBAminus -150.83, -160.56 -160.34, 120.0 -81.87, -18.31 276.95, 79.02 -92.52, 170.28 in-in in 7.814 Saltbr-in 2.696 HRD-in -75.66, -51.7 79.36, -13.13 in-out-in SNCioi out-in ActLoopNT-out 6.647 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.12, 134.88 APE9-dihe-in -108.63, 131.61 APE8-dihe-in -62.36, 119.6 APE8-rot-na 29.91 APE67-dihe-in -70.7, -20.49 -52.84, -40.81 APE12-dist-na 12.461 APE11-dist-na 9.603 APE10-dist-na 12.547 APE9-dist-in 6.155 None None None XRAY 2.1 0.195 0.256 A 270 265 0 0 0 0 [[242, 495]] 1.0 2hz0 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HZ0B P00519 228 497 1130.0 GIN:600 Type2 Inactive DFGout 16.145 10.288 BBAminus -144.12, -165.06 -157.27, 107.1 -67.75, -17.6 276.47, 79.62 51.54, 32.42 in-in in 7.851 Saltbr-in 2.502 HRD-in -77.02, -51.65 87.26, -10.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.38 APE8-rot-na 355.54 APE67-dihe-in -66.19, -16.4 -42.69, -41.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.195 0.256 B 270 243 27 0 0 17 [[242, 495]] 1.0 2hz0 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HYYA P00519 235 498 1130.0 STI:600 Type2 Inactive DFGout 13.448 10.936 BBAminus -136.71, -169.54 -156.86, 107.67 -99.35, 1.46 307.94, 127.18 66.47, 52.08 in-in in 8.239 Saltbr-in 3.004 HRD-in -68.42, -63.13 91.16, -9.54 in-out-in SNCioi out-in ActLoopNT-out 16.099 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.4, 131.38 APE9-dihe-in -122.46, 141.0 APE8-dihe-in -82.09, 92.82 APE8-rot-na 22.51 APE67-dihe-in -74.51, -8.92 -44.66, -47.4 APE12-dist-na 14.458 APE11-dist-na 11.901 APE10-dist-na 8.415 APE9-dist-in 7.394 None None None XRAY 2.4 0.208 0.267 A 273 263 1 0 0 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HYYB P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.607 10.838 BBAminus -140.46, -179.87 -145.37, 104.9 -88.0, -4.17 302.17, 134.32 68.19, 47.44 in-in in 8.468 Saltbr-in 2.974 HRD-in -72.33, -53.74 81.02, -14.85 in-out-in SNCioi out-in ActLoopNT-out 15.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.08, 127.85 APE9-dihe-in -116.06, 145.63 APE8-dihe-in -88.84, 91.14 APE8-rot-na 22.78 APE67-dihe-in -77.2, -5.94 -46.52, -42.21 APE12-dist-na 14.479 APE11-dist-na 11.949 APE10-dist-na 8.421 APE9-dist-in 7.417 None None None XRAY 2.4 0.208 0.267 B 273 265 1 0 0 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HYYC P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.817 11.145 BBAminus -136.58, -170.43 -156.15, 102.72 -91.16, -2.19 306.71, 138.1 61.3, 49.16 in-in in 8.291 Saltbr-in 3.409 HRD-in -75.29, -48.77 83.65, -17.42 in-out-in SNCioi out-in ActLoopNT-out 15.636 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.7, 128.89 APE9-dihe-in -132.69, 141.39 APE8-dihe-in -86.44, 89.34 APE8-rot-na 30.23 APE67-dihe-in -75.71, -10.45 -48.99, -40.28 APE12-dist-na 15.628 APE11-dist-na 13.532 APE10-dist-na 8.776 APE9-dist-in 7.515 None None None XRAY 2.4 0.208 0.267 C 273 262 4 0 0 3 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HYYD P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.627 11.008 BBAminus -135.11, -170.82 -155.12, 109.43 -96.64, 9.5 309.68, 132.23 60.03, 43.1 in-in in 8.009 Saltbr-in 2.758 HRD-in -69.95, -55.57 86.15, -21.95 in-out-in SNCioi out-in ActLoopNT-out 15.335 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 121.23 APE9-dihe-in -126.0, 140.68 APE8-dihe-in -79.93, 90.29 APE8-rot-na 35.26 APE67-dihe-in -80.44, -14.01 -57.15, -31.16 APE12-dist-na 15.675 APE11-dist-na 13.475 APE10-dist-na 8.574 APE9-dist-in 7.555 None None None XRAY 2.4 0.208 0.267 D 273 264 2 0 0 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3CS9A P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.593 11.118 BBAminus -145.37, -175.21 -153.52, 95.68 -79.44, 2.63 308.67, 139.53 60.14, 48.09 in-in in 7.987 Saltbr-in 2.959 HRD-in -72.5, -52.05 83.05, -14.51 in-out-in SNCioi out-in ActLoopNT-out 15.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.13, 125.61 APE9-dihe-in -114.38, 144.88 APE8-dihe-in -83.08, 84.52 APE8-rot-na 33.34 APE67-dihe-in -71.16, -7.94 -52.7, -43.38 APE12-dist-na 15.638 APE11-dist-na 11.341 APE10-dist-na 8.586 APE9-dist-in 7.762 None None None XRAY 2.21 0.2 0.242 A 277 264 4 0 0 0 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3CS9B P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.456 10.753 BBAminus -144.0, -176.67 -148.15, 110.4 -103.8, 0.8 309.16, 135.76 150.34, 999.0 in-in in 8.222 Saltbr-in 3.48 HRD-in -70.96, -54.76 81.36, -12.94 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.55 APE8-rot-na 31.92 APE67-dihe-in -70.26, -17.41 -42.99, -45.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 B 277 247 21 0 0 18 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3CS9C P00519 232 497 1130.0 NIL:600 Type2 Inactive DFGout 13.712 10.918 BBAminus -141.39, 177.78 -141.43, 100.61 -84.1, -4.94 304.15, 138.08 61.69, 999.0 in-in in 7.955 Saltbr-in 2.828 HRD-in -74.87, -48.82 81.89, -13.85 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.51 APE8-rot-na 36.98 APE67-dihe-in -69.35, -10.43 -43.96, -42.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 C 277 243 23 0 0 18 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3CS9D P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.778 11.757 BBAminus -137.25, -170.7 -151.81, 104.77 -89.11, 0.3 306.25, 137.53 63.13, 44.73 in-in in 7.888 Saltbr-in 2.74 HRD-in -68.82, -44.23 79.28, -14.07 in-out-in SNCioi out-in ActLoopNT-out 15.59 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.05, 117.02 APE9-dihe-in -109.67, 147.03 APE8-dihe-in -87.1, 85.65 APE8-rot-na 29.26 APE67-dihe-in -63.61, -19.67 -51.69, -46.78 APE12-dist-na 16.15 APE11-dist-na 12.15 APE10-dist-na 8.758 APE9-dist-in 7.581 None None None XRAY 2.21 0.2 0.242 D 277 263 5 0 0 0 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3QRIA P00519 229 498 1130.0 919:60500 Type2 Inactive DFGout 13.405 9.244 BBAminus -140.23, -177.67 -143.73, 111.06 -85.62, -1.21 285.71, 95.83 64.84, 45.13 in-in in 7.938 Saltbr-in 2.671 HRD-in -68.59, -54.98 84.86, -16.08 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.68, 128.64 APE9-dihe-in -141.86, 154.54 APE8-dihe-in -79.64, 85.81 APE8-rot-na 26.51 APE67-dihe-in -72.47, -7.02 -44.71, -48.72 APE12-dist-na 18.499 APE11-dist-na 15.586 APE10-dist-na 10.726 APE9-dist-in 7.426 None None None XRAY 2.1 0.216 0.272 A 277 270 0 0 0 0 [[242, 495]] 1.0 3qri Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3QRIB P00519 232 498 1130.0 919:60002 Type2 Inactive DFGout 13.394 9.355 BBAminus -137.99, -177.06 -143.59, 113.56 -88.43, -2.03 287.13, 98.7 64.72, 47.42 in-in in 7.851 Saltbr-in 2.857 HRD-in -75.25, -51.53 85.01, -17.97 in-out-in SNCioi out-in ActLoopNT-out 15.327 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.54, 128.19 APE9-dihe-in -140.43, 156.29 APE8-dihe-in -80.95, 78.25 APE8-rot-na 29.21 APE67-dihe-in -73.74, -7.02 -42.67, -45.53 APE12-dist-na 18.487 APE11-dist-na 15.562 APE10-dist-na 10.79 APE9-dist-in 7.48 None None None XRAY 2.1 0.216 0.272 B 277 262 5 0 0 0 [[242, 495]] 1.0 3qri Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HIWA P00519 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.347 10.826 BBAminus -142.71, -168.33 -158.01, 107.74 -97.35, 2.37 312.36, 126.58 65.32, 50.81 in-out in 8.229 Saltbr-out 3.74 HRD-in -73.86, -48.39 84.66, -24.64 out-out-in SNCooi out-in ActLoopNT-out 15.637 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 130.36 APE9-dihe-in -115.68, 135.96 APE8-dihe-in -85.15, 68.17 APE8-rot-na 24.2 APE67-dihe-in -72.17, -12.42 -32.25, -48.66 APE12-dist-na 13.573 APE11-dist-na 12.475 APE10-dist-na 8.19 APE9-dist-in 7.724 None None None XRAY 2.2 0.246 0.309 A 287 270 0 0 0 0 [[242, 495]] 1.0 2hiw Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HIWB P00519 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.088 11.207 BBAminus -144.46, -168.71 -161.12, 102.71 -97.39, 4.98 318.67, 117.06 56.31, 54.08 in-in in 8.015 Saltbr-in 2.787 HRD-in -67.44, -50.02 79.19, -15.91 in-out-in SNCioi out-in ActLoopNT-out 15.965 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.79, 117.59 APE9-dihe-in -110.67, 133.98 APE8-dihe-in -80.14, 91.72 APE8-rot-na 27.82 APE67-dihe-in -76.13, -9.39 -64.08, -40.93 APE12-dist-na 14.695 APE11-dist-na 12.519 APE10-dist-na 8.495 APE9-dist-in 7.672 None None None XRAY 2.2 0.246 0.309 B 287 270 0 0 0 0 [[242, 495]] 1.0 2hiw Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2E2BA P00519 229 502 1130.0 406:61001 Type2 Inactive DFGout 13.637 10.914 BBAminus -135.1, -171.45 -153.85, 101.44 -92.52, 5.9 308.25, 136.28 52.63, 55.21 in-in in 8.439 Saltbr-in 2.958 HRD-in -72.49, -53.7 81.83, -19.66 in-out-in SNCioi out-in ActLoopNT-out 15.483 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.77, 121.49 APE9-dihe-in -121.85, 146.58 APE8-dihe-in -80.67, 88.23 APE8-rot-na 34.75 APE67-dihe-in -71.79, -9.02 -46.22, -43.83 APE12-dist-na 15.609 APE11-dist-na 11.355 APE10-dist-na 8.517 APE9-dist-in 7.271 None None None XRAY 2.2 0.236 0.27 A 293 266 8 0 0 4 [[242, 495]] 1.0 2e2b Homo sapiens TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2E2BB P00519 229 497 1130.0 406:61002 Type2 Inactive DFGout 13.647 10.933 BBAminus -143.5, -176.35 -149.87, 101.4 -87.9, 0.31 305.42, 141.47 55.35, 49.49 in-in in 8.452 Saltbr-in 2.852 HRD-in -72.44, -52.01 77.65, -14.12 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.83, 116.83 APE9-dihe-in -124.88, 142.96 APE8-dihe-in -78.59, 83.23 APE8-rot-na 29.89 APE67-dihe-in -65.0, -9.5 -42.19, -50.29 APE12-dist-na 15.656 APE11-dist-na 11.831 APE10-dist-na 8.469 APE9-dist-in 7.22 None None None XRAY 2.2 0.236 0.27 B 293 258 11 0 0 6 [[242, 495]] 1.0 2e2b Homo sapiens TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 5HU9A P00519 229 499 1130.0 66K:60601,66K:60602 Type2,Allosteric Inactive DFGout 15.803 10.497 BBAminus -145.4, -177.31 -141.71, 111.16 -69.31, -26.01 283.1, 65.03 93.44, 13.86 in-in in 8.083 Saltbr-in 2.769 HRD-in -68.36, -51.36 83.46, -11.3 in-out-out SNCioo out-out ActLoopNT-out 13.313 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -72.36, -42.02 APE9-dihe-in -132.05, 79.59 APE8-dihe-in -81.54, 66.0 APE8-rot-na 26.81 APE67-dihe-in -69.94, -12.93 -59.43, -37.79 APE12-dist-na 9.509 APE11-dist-na 5.455 APE10-dist-na 6.094 APE9-dist-out 9.516 None None None XRAY 1.529 0.186 0.196 A 277 266 5 0 0 5 [[242, 495]] 1.0 5hu9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3PYYA P00519 232 500 1130.0 STI:60003,3YY:60538 Type2,Allosteric Inactive DFGout 13.647 11.262 BBAminus -130.42, -173.45 -148.82, 100.51 -87.29, -2.92 301.78, 132.98 62.26, 50.77 in-in in 8.143 Saltbr-in 2.677 HRD-in -77.84, -60.13 91.69, -13.02 in-out-in SNCioi out-in ActLoopNT-out 15.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.57, 117.7 APE9-dihe-in -121.79, 141.76 APE8-dihe-in -85.05, 87.91 APE8-rot-na 30.64 APE67-dihe-in -73.12, -6.21 -47.76, -45.73 APE12-dist-na 16.525 APE11-dist-na 12.81 APE10-dist-na 8.696 APE9-dist-in 7.729 None None None XRAY 1.85 0.189 0.204 A 298 265 4 0 0 0 [[242, 495]] 1.0 3pyy Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3PYYB P00519 233 510 1130.0 STI:60004,3YY:60532 Type2,Allosteric Inactive DFGout 13.97 11.017 BBAminus -132.59, -172.42 -152.94, 105.37 -94.38, -50.82 313.04, 135.61 93.2, 999.0 in-in in 8.1 Saltbr-in 2.571 HRD-in -81.0, -57.03 86.3, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -127.99, 138.02 APE9-dihe-in -152.66, 146.9 APE8-dihe-in -80.16, 79.64 APE8-rot-na 29.64 APE67-dihe-in -75.32, -11.37 -49.83, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.258 None None None XRAY 1.85 0.189 0.204 B 298 257 21 0 0 15 [[242, 495]] 1.0 3pyy Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6NPEA P00519 232 500 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.751 11.277 BBAminus -132.09, -171.87 -150.82, 100.43 -86.72, -1.03 301.5, 131.9 61.32, 51.13 in-in in 8.171 Saltbr-in 2.779 HRD-in -75.05, -56.53 78.97, -9.5 in-out-in SNCioi out-in ActLoopNT-out 15.736 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.77, 121.63 APE9-dihe-in -123.35, 140.69 APE8-dihe-in -84.02, 84.76 APE8-rot-na 23.95 APE67-dihe-in -76.42, -6.93 -49.4, -44.5 APE12-dist-na 16.592 APE11-dist-na 12.788 APE10-dist-na 8.752 APE9-dist-in 7.844 None None None XRAY 2.15 0.187 0.212 A 298 264 5 0 0 0 [[242, 495]] 1.0 6npe Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6NPEB P00519 233 511 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.84 11.101 BBAminus -129.89, -169.38 -152.66, 105.04 -92.73, -27.9 303.95, 134.44 82.3, 999.0 in-in in 8.222 Saltbr-in 2.684 HRD-in -80.48, -54.98 79.49, -7.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.9 APE8-dihe-in -75.88, 86.79 APE8-rot-na 23.52 APE67-dihe-in -70.62, -18.32 -51.39, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.686 None None None XRAY 2.15 0.187 0.212 B 298 256 23 0 0 17 [[242, 495]] 1.0 6npe Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6NPUA P00519 232 500 1130.0 STI:60601,KWV:60602 Type2,Allosteric Inactive DFGout 13.724 11.341 BBAminus -131.32, -177.82 -147.63, 103.5 -91.61, -2.68 302.6, 133.1 64.49, 56.03 in-in in 8.175 Saltbr-in 2.643 HRD-in -76.28, -58.38 85.82, -8.07 in-out-in SNCioi out-in ActLoopNT-out 15.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 129.98 APE9-dihe-in -123.79, 139.52 APE8-dihe-in -78.9, 90.13 APE8-rot-na 28.21 APE67-dihe-in -75.75, -3.63 -52.56, -44.81 APE12-dist-na 16.312 APE11-dist-na 12.598 APE10-dist-na 8.715 APE9-dist-in 7.801 None None None XRAY 2.33 0.196 0.234 A 298 264 5 0 0 0 [[242, 495]] 1.0 6npu Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6NPUB P00519 233 510 1130.0 STI:60602,KWV:60605 Type2,Allosteric Inactive DFGout 13.716 11.121 BBAminus -136.03, -173.76 -148.73, 104.54 -94.68, -39.85 309.09, 136.14 93.88, 999.0 in-in in 8.046 Saltbr-in 2.655 HRD-in -88.42, -57.18 82.99, -10.02 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.51, 88.48 APE9-dihe-in -97.46, 155.87 APE8-dihe-in -87.38, 82.63 APE8-rot-na 29.77 APE67-dihe-in -64.85, -22.06 -45.68, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.855 None None None XRAY 2.33 0.196 0.234 B 298 257 21 0 0 15 [[242, 495]] 1.0 6npu Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6NPVA P00519 232 500 1130.0 STI:60602,KWP:60603 Type2,Allosteric Inactive DFGout 13.575 11.211 BBAminus -133.43, -176.32 -147.26, 102.27 -88.44, -2.86 301.02, 133.29 64.03, 50.03 in-in in 8.158 Saltbr-in 2.969 HRD-in -74.61, -59.03 88.55, -10.34 in-out-in SNCioi out-in ActLoopNT-out 15.738 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.7, 120.65 APE9-dihe-in -115.73, 140.1 APE8-dihe-in -81.63, 87.3 APE8-rot-na 30.14 APE67-dihe-in -75.75, -5.01 -52.83, -44.97 APE12-dist-na 16.303 APE11-dist-na 12.284 APE10-dist-na 8.713 APE9-dist-in 7.782 None None None XRAY 1.86 0.183 0.207 A 298 264 5 0 0 0 [[242, 495]] 1.0 6npv Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6NPVB P00519 233 510 1130.0 STI:60603,KWP:60607 Type2,Allosteric Inactive DFGout 13.545 11.062 BBAminus -135.7, -168.07 -155.88, 101.76 -93.13, -7.53 306.52, 136.97 78.01, 999.0 in-in in 8.2 Saltbr-in 2.751 HRD-in -76.84, -57.95 84.26, -8.39 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.75, 102.42 APE9-dihe-in -114.18, 151.63 APE8-dihe-in -86.78, 85.36 APE8-rot-na 20.0 APE67-dihe-in -75.22, -6.58 -51.86, -43.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.966 None None None XRAY 1.86 0.183 0.207 B 298 257 21 0 0 15 [[242, 495]] 1.0 6npv Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3QRKA P00519 229 496 1130.0 9DP:60001 Type3 Inactive DFGout 13.538 9.263 BBAminus -128.74, -174.73 -147.03, 106.14 -83.7, 8.0 281.11, 96.68 56.22, 46.71 in-in in 7.853 Saltbr-in 2.674 HRD-in -77.83, -51.71 87.8, -21.18 in-out-in SNCioi out-in ActLoopNT-out 15.303 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.14, 132.07 APE9-dihe-in -145.7, 147.79 APE8-dihe-in -79.52, 88.76 APE8-rot-na 26.7 APE67-dihe-in -65.94, -15.53 -54.88, -43.49 APE12-dist-na 18.815 APE11-dist-na 15.758 APE10-dist-na 10.991 APE9-dist-in 7.585 None None None XRAY 2.3 0.192 0.281 A 277 268 0 0 0 0 [[242, 495]] 1.0 3qrk Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G2FB P00519 234 502 1130.0 AGS:601 ATPlike Inactive DFGout 13.477 11.525 None -73.05, 151.22 -78.4, -31.56 -2.81, -74.15 167.03, 54.1 -90.78, 24.63 in-in in 8.896 Saltbr-in 3.373 HRD-out -112.09, 115.32 -73.34, -1.05 in-out-in SNCioi out-in ActLoopNT-out 5.759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.67, 144.36 APE9-dihe-in -134.57, 156.36 APE8-dihe-in -59.22, 104.92 APE8-rot-na 31.18 APE67-dihe-in -59.35, -15.8 -52.01, -51.94 APE12-dist-na 18.887 APE11-dist-na 14.3 APE10-dist-na 17.687 APE9-dist-in 6.818 H396P None None XRAY 2.7 0.234 0.286 B 287 264 5 0 0 0 [[242, 495]] 1.0 2g2f Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 6XR7A P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.443 8.628 None -113.31, -174.74 -119.02, 30.04 -65.72, 104.77 191.29, 77.0 102.04, -118.08 in-in in 7.642 Saltbr-in 2.805 HRD-in -104.45, -51.55 70.39, 1.66 in-out-out SNCioo out-out ActLoopNT-out 4.962 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 60.98, -93.15 APE9-dihe-out 55.27, 119.08 APE8-dihe-in -62.33, 109.76 APE8-rot-na 22.3 APE67-dihe-in -67.97, -13.01 -57.05, -38.83 APE12-dist-na 12.258 APE11-dist-na 9.513 APE10-dist-na 11.208 APE9-dist-in 7.706 None None None NMR 999.0 999.0 999.0 A 287 287 0 0 0 0 [[242, 495]] 1.0 6xr7 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8I7TB P00519 232 500 1130.0 6I5:601 Type1 Inactive DFGout 13.413 11.662 None -78.21, 133.76 -76.1, -34.26 58.37, -123.75 266.71, 82.63 -125.63, 98.01 in-in in 9.576 Saltbr-in 3.259 HRD-in -106.12, -52.02 70.25, 2.56 in-out-in SNCioi out-in ActLoopNT-out 5.657 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.56, 141.45 APE9-dihe-in -118.71, 149.22 APE8-dihe-in -71.44, 98.5 APE8-rot-na 25.12 APE67-dihe-in -70.33, -18.58 -57.67, -41.4 APE12-dist-na 18.142 APE11-dist-na 13.598 APE10-dist-na 16.985 APE9-dist-in 6.851 None PTR393 PTR393 XRAY 2.8 0.221 0.272 B 272 263 6 0 0 0 [[242, 495]] 1.0 8i7t Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HZIA P00519 233 500 1130.0 JIN:600 Type1 Inactive DFGout 12.672 11.025 None -64.65, 136.57 -117.47, 21.9 -67.4, 155.9 48.8, 72.68 74.75, 2.18 in-in in 8.01 Saltbr-in 2.751 HRD-in -100.41, -50.8 74.37, -4.5 in-out-in SNCioi out-in ActLoopNT-out 5.602 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.67, 131.39 APE9-dihe-in -115.42, 162.87 APE8-dihe-in -80.35, 88.85 APE8-rot-na 20.47 APE67-dihe-in -70.91, -11.25 -48.9, -44.37 APE12-dist-na 19.444 APE11-dist-na 14.856 APE10-dist-na 17.691 APE9-dist-in 7.179 None None None XRAY 1.7 0.177 0.204 A 277 268 0 0 0 0 [[242, 495]] 1.0 2hzi Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4ZOGB P00519 234 503 1130.0 VX6:601 Type1 Inactive DFGout 11.789 11.828 None -72.45, 126.77 -115.82, 44.9 -59.71, -111.34 30.08, 49.18 -63.43, 48.35 in-in in 8.88 Saltbr-in 3.108 HRD-in -92.87, -52.54 77.42, -2.86 in-out-in SNCioi out-in ActLoopNT-out 5.5 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.26, 120.92 APE9-dihe-in -100.0, 141.29 APE8-dihe-in -74.27, 97.66 APE8-rot-na 25.54 APE67-dihe-in -72.2, -10.54 -59.59, -40.07 APE12-dist-na 17.856 APE11-dist-na 13.858 APE10-dist-na 16.207 APE9-dist-in 6.99 None None None XRAY 2.3 0.187 0.233 B 283 268 2 0 0 2 [[242, 495]] 1.0 4zog Homo sapiens TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4WA9B P00519 246 508 1130.0 AXI:69000 Type1 Inactive DFGout 13.311 10.281 None -75.93, 149.51 -77.88, -15.66 -59.19, 118.14 191.81, 69.86 106.96, -1.52 in-in in 7.643 Saltbr-in 2.056 HRD-out -116.7, 121.02 -81.78, -7.12 in-out-in SNCioi out-in ActLoopNT-out 5.327 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.35, 121.29 APE9-dihe-in -115.41, 155.9 APE8-dihe-in -66.84, 110.63 APE8-rot-na 32.52 APE67-dihe-in -70.78, -12.55 -43.03, -46.3 APE12-dist-na 18.5 APE11-dist-na 13.938 APE10-dist-na 17.498 APE9-dist-in 6.711 None None None XRAY 2.2 0.175 0.212 B 286 263 0 0 0 0 [[242, 495]] 1.0 4wa9 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3UE4A P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.471 10.087 None -73.57, 139.68 -129.47, 18.74 -70.04, -27.22 71.97, 85.11 -97.86, 45.9 in-out in 8.122 Saltbr-out 4.005 HRD-out -105.15, 128.48 -83.8, -2.91 out-out-in SNCooi out-in ActLoopNT-out 5.294 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 137.39 APE9-dihe-in -119.63, 157.7 APE8-dihe-in -69.93, 97.57 APE8-rot-na 25.4 APE67-dihe-in -65.99, -15.91 -45.97, -49.68 APE12-dist-na 19.211 APE11-dist-na 14.469 APE10-dist-na 17.122 APE9-dist-in 6.836 None None None XRAY 2.424 0.192 0.249 A 287 270 0 0 0 0 [[242, 495]] 1.0 3ue4 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 3UE4B P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.224 10.48 None -68.43, 143.68 -139.88, 24.33 -73.48, -36.67 65.16, 97.6 -93.69, 7.14 in-out in 8.491 Saltbr-out 3.771 HRD-in -88.28, -56.6 76.68, -0.41 out-out-in SNCooi out-in ActLoopNT-out 5.441 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.79, 122.21 APE9-dihe-in -108.43, 151.01 APE8-dihe-in -71.16, 105.45 APE8-rot-na 24.97 APE67-dihe-in -72.18, -12.67 -59.58, -44.17 APE12-dist-na 19.453 APE11-dist-na 14.748 APE10-dist-na 17.212 APE9-dist-in 6.892 None None None XRAY 2.424 0.192 0.249 B 287 268 2 0 0 0 [[242, 495]] 1.0 3ue4 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 8I7TA P00519 232 500 1130.0 6I5:601 Type1.5_Back Inactive DFGout 13.264 11.956 None -62.98, 128.57 -72.85, -7.53 36.94, -135.32 264.95, 6.34 101.46, 15.06 in-in in 8.596 Saltbr-in 3.276 HRD-in -96.98, -47.23 68.77, 7.6 in-out-in SNCioi out-in ActLoopNT-out 5.853 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.95, 130.91 APE9-dihe-in -108.03, 159.47 APE8-dihe-in -73.45, 92.08 APE8-rot-na 23.57 APE67-dihe-in -76.01, -8.31 -52.5, -40.25 APE12-dist-na 19.734 APE11-dist-na 15.138 APE10-dist-na 18.068 APE9-dist-in 7.311 None PTR393 PTR393 XRAY 2.8 0.221 0.272 A 272 267 2 0 0 0 [[242, 495]] 1.0 8i7t Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2HZIB P00519 233 500 1130.0 JIN:600 Type1.5_Back Inactive DFGout 12.651 10.8 None -64.82, 139.58 -123.5, 22.46 -72.33, 154.15 44.58, 70.92 81.45, -10.45 in-in in 8.048 Saltbr-in 2.788 HRD-in -103.52, -56.2 76.53, -2.92 in-out-in SNCioi out-in ActLoopNT-out 5.534 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.65, 133.63 APE9-dihe-in -122.59, 157.35 APE8-dihe-in -72.25, 93.6 APE8-rot-na 22.08 APE67-dihe-in -66.73, -17.62 -46.65, -45.74 APE12-dist-na 19.118 APE11-dist-na 14.407 APE10-dist-na 17.185 APE9-dist-in 6.795 None None None XRAY 1.7 0.177 0.204 B 277 264 4 0 0 0 [[242, 495]] 1.0 2hzi Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2G2HB P00519 233 504 1130.0 P16:60532 Type1.5_Back Inactive DFGout 12.699 10.5 None -60.13, 139.26 -82.96, -16.55 -75.2, 165.15 55.98, 67.58 79.14, 12.62 in-out in 8.193 Saltbr-out 6.859 HRD-out -104.81, 126.85 -89.37, -5.07 out-out-in SNCooi out-in ActLoopNT-out 5.481 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.1, 135.12 APE9-dihe-in -121.36, 158.85 APE8-dihe-in -60.74, 105.18 APE8-rot-na 332.86 APE67-dihe-in -67.82, -12.38 -45.03, -49.81 APE12-dist-na 18.669 APE11-dist-na 13.902 APE10-dist-na 17.244 APE9-dist-in 6.55 H396P None None XRAY 2.0 0.194 0.213 B 287 272 0 0 0 0 [[242, 495]] 1.0 2g2h Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 2FO0A P00519 46 511 1130.0 P16:60702 Type1.5_Back Inactive DFGout 13.447 11.785 None -76.52, 118.23 -95.45, 43.06 -89.94, 155.29 62.25, 72.76 62.2, 26.15 in-in in 8.055 Saltbr-in 3.154 HRD-in -101.49, -60.91 80.44, -3.96 in-out-in SNCioi out-in ActLoopNT-out 5.763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.77, 155.96 APE9-dihe-in -130.48, 150.83 APE8-dihe-in -76.1, 87.73 APE8-rot-na 30.01 APE67-dihe-in -55.48, -20.39 -31.31, -58.23 APE12-dist-na 19.757 APE11-dist-na 15.052 APE10-dist-na 18.053 APE9-dist-in 7.226 D363N SEP50 SEP50 XRAY 2.27 0.21 0.246 A 495 466 0 0 0 0 [[242, 495]] 1.0 2fo0 Homo sapiens TYR_ABL1_HUMAN TYR 5.5e-99 337.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 1OPLA P00519 62 512 1130.0 P16:60539 Type1.5_Back Inactive DFGout 12.808 11.67 None -65.59, 134.14 -116.03, 33.28 -83.5, 159.91 53.21, 70.33 67.06, 8.01 in-in in 7.953 Saltbr-in 2.944 HRD-in -97.12, -53.99 73.72, -6.86 in-out-in SNCioi out-in ActLoopNT-out 5.553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.98, 127.83 APE9-dihe-in -117.56, 161.51 APE8-dihe-in -80.15, 93.03 APE8-rot-na 30.65 APE67-dihe-in -63.53, -19.0 -41.82, -48.43 APE12-dist-na 19.483 APE11-dist-na 14.757 APE10-dist-na 17.435 APE9-dist-in 7.125 K12R,D363N None None XRAY 3.42 0.306 0.315 A 537 451 0 0 0 0 [[242, 495]] 1.0 1opl Homo sapiens TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 1OPLB P00519 121 499 1130.0 P16:60538 Type1.5_Back Inactive DFGout 12.196 11.59 None -63.84, 141.4 -115.91, 33.22 -83.51, 160.0 53.06, 70.48 67.02, 7.94 in-in in 7.991 Saltbr-in 2.943 HRD-in -97.28, -53.9 73.81, -6.95 in-out-in SNCioi out-in ActLoopNT-out 5.553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.01, 127.73 APE9-dihe-in -117.46, 161.57 APE8-dihe-in -80.14, 92.99 APE8-rot-na 30.73 APE67-dihe-in -63.44, -19.12 -41.75, -48.48 APE12-dist-na 19.482 APE11-dist-na 14.757 APE10-dist-na 17.436 APE9-dist-in 7.125 K12R,D363N None None XRAY 3.42 0.306 0.315 B 537 365 0 0 0 0 [[242, 495]] 1.0 1opl Homo sapiens TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 5MO4A P00519 64 512 1130.0 NIL:60601,AY7:60602 Type2,Allosteric Inactive DFGout 13.947 11.318 None -138.43, -177.76 -149.4, 98.71 -92.55, 999.0 320.75, 134.82 999.0, 999.0 in-in in 8.106 Saltbr-in 2.797 HRD-in -66.66, -50.58 73.57, -12.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -49.47 APE8-dihe-out -61.4, -6.43 APE8-rot-na 335.89 APE67-dihe-in -62.17, -20.21 -56.07, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.098 None None None XRAY 2.17 0.184 0.217 A 495 429 20 0 0 18 [[242, 495]] 1.0 5mo4 Homo sapiens TYR_ABL1_HUMAN TYR 1.1e-98 336.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_HUMAN 4WA9A P00519 246 504 1130.0 AXI:69000 Type1 Inactive None 999.0 10.355 None -73.83, 149.34 -77.87, -21.14 -66.14, 121.84 190.75, 64.67 115.23, -11.12 none-none none 999.0 Saltbr-none 999.0 HRD-out -124.23, 124.72 -84.31, -3.72 none-out-in SNCnoi out-in ActLoopNT-out 5.409 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.89, 135.91 APE9-dihe-in -108.88, 156.35 APE8-dihe-in -71.91, 93.83 APE8-rot-na 24.22 APE67-dihe-in -74.38, -8.52 -49.97, -43.55 APE12-dist-na 18.561 APE11-dist-na 13.777 APE10-dist-na 16.661 APE9-dist-in 6.491 None None None XRAY 2.2 0.175 0.212 A 286 236 23 0 0 0 [[242, 495]] 1.0 4wa9 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 2Z60A P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.849 13.481 BLAminus -137.02, -172.04 59.64, 81.83 -96.6, 21.67 303.76, 107.0 -57.3, -29.84 in-in in 7.709 Saltbr-in 2.641 HRD-in -89.4, -48.82 73.73, 3.17 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.81, 154.38 APE9-dihe-in -134.15, 168.28 APE8-dihe-in -62.25, 96.21 APE8-rot-na 339.53 APE67-dihe-in -71.21, -15.43 -42.73, -46.48 APE12-dist-na 15.564 APE11-dist-na 10.729 APE10-dist-na 13.421 APE9-dist-in 7.263 T315I None None XRAY 1.95 0.206 0.245 A 288 280 3 0 0 0 [[242, 495]] 1.0 2z60 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 2QOHA P00520 229 501 1123.0 P3Y:60001 Type1 Active DFGin 6.792 13.3 BLAminus -137.18, -173.6 58.31, 89.23 -103.73, 22.71 305.14, 99.76 -56.65, -30.84 in-in in 7.833 Saltbr-in 2.648 HRD-in -86.16, -51.73 78.16, -1.08 in-in-in SNCiii in-in ActLoopNT-in 3.171 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.12, 148.82 APE9-dihe-in -123.25, 167.08 APE8-dihe-in -79.06, 86.62 APE8-rot-na 341.05 APE67-dihe-in -62.47, -15.79 -35.13, -54.47 APE12-dist-na 15.229 APE11-dist-na 10.546 APE10-dist-na 13.183 APE9-dist-in 7.319 None None None XRAY 1.95 0.214 0.255 A 288 270 3 0 0 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 2QOHB P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.954 13.03 BLAminus -146.85, -174.9 61.51, 81.39 -99.78, 25.49 304.24, 93.09 -56.89, -22.43 in-in in 7.883 Saltbr-in 2.721 HRD-in -91.49, -48.67 74.38, 6.2 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.22, 145.99 APE9-dihe-in -127.49, 165.6 APE8-dihe-in -83.22, 84.35 APE8-rot-na 349.39 APE67-dihe-in -72.21, -14.36 -35.43, -45.09 APE12-dist-na 15.247 APE11-dist-na 10.505 APE10-dist-na 12.838 APE9-dist-in 7.4 None None None XRAY 1.95 0.214 0.255 B 288 280 3 0 0 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KF4A P00520 229 514 1123.0 B90:1 Type1.5_Back Active DFGin 6.717 13.487 BLAminus -138.47, -169.78 64.32, 74.67 -103.01, 17.52 308.56, 103.02 -57.24, -29.09 in-in in 8.038 Saltbr-in 2.842 HRD-in -97.68, -52.38 80.64, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 154.17 APE9-dihe-in -130.7, 158.73 APE8-dihe-in -75.38, 102.27 APE8-rot-na 27.21 APE67-dihe-in -74.45, -9.72 -55.5, -39.82 APE12-dist-na 14.483 APE11-dist-na 10.063 APE10-dist-na 13.048 APE9-dist-in 7.316 None None None XRAY 1.9 0.197 0.24 A 288 281 5 0 0 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KF4B P00520 229 501 1123.0 B90:1 Type1.5_Back Active DFGin 6.673 13.649 BLAminus -131.98, -172.92 66.04, 78.12 -105.54, 16.69 306.01, 100.01 -53.92, -33.68 in-in in 8.099 Saltbr-in 2.87 HRD-in -96.09, -52.11 78.87, 6.97 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.63, 136.23 APE9-dihe-in -115.19, 156.97 APE8-dihe-in -69.24, 107.22 APE8-rot-na 26.84 APE67-dihe-in -70.3, -19.91 -54.93, -42.84 APE12-dist-na 15.155 APE11-dist-na 10.396 APE10-dist-na 13.206 APE9-dist-in 7.469 None None None XRAY 1.9 0.197 0.24 B 288 270 3 0 0 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK7A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.521 4.47 None -65.94, 133.62 -136.37, 26.36 -59.29, -46.94 277.65, 138.09 -96.98, 21.57 in-in in 7.766 Saltbr-in 2.793 HRD-in -90.33, -58.06 79.79, -1.99 in-out-in SNCioi out-in ActLoopNT-out 5.675 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.5, 130.75 APE9-dihe-in -114.11, 153.09 APE8-dihe-in -69.74, 90.62 APE8-rot-na 25.02 APE67-dihe-in -72.01, -11.59 -51.31, -42.54 APE12-dist-na 20.579 APE11-dist-na 15.929 APE10-dist-na 18.225 APE9-dist-in 7.447 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 A 277 266 4 0 0 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK6A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.835 8.306 None -61.57, 128.5 -127.52, 27.29 -83.26, -21.75 331.68, 119.16 -112.49, 27.73 in-in in 7.974 Saltbr-in 2.893 HRD-in -91.42, -55.08 73.35, 1.27 in-out-in SNCioi out-in ActLoopNT-out 5.66 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.77, 134.59 APE9-dihe-in -117.57, 154.09 APE8-dihe-in -69.69, 91.12 APE8-rot-na 24.6 APE67-dihe-in -73.26, -8.23 -48.64, -44.69 APE12-dist-na 20.525 APE11-dist-na 15.941 APE10-dist-na 18.171 APE9-dist-in 7.39 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 A 293 263 7 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK6B P00520 234 505 1123.0 SX7:2 Type1 Inactive DFGinter 9.607 8.211 None -63.13, 129.74 -127.1, 39.65 -91.94, -7.89 322.45, 123.44 -137.52, 35.5 in-none in 8.477 Saltbr-none 999.0 HRD-in -90.89, -55.29 76.04, -7.16 none-out-in SNCnoi out-in ActLoopNT-out 5.58 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.73, 139.41 APE9-dihe-in -127.03, 148.23 APE8-dihe-in -65.18, 97.87 APE8-rot-na 342.63 APE67-dihe-in -74.45, -10.42 -49.61, -43.27 APE12-dist-na 18.841 APE11-dist-na 14.184 APE10-dist-na 17.301 APE9-dist-in 6.943 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 B 293 260 12 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK3A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.037 4.534 None -66.29, 133.89 -136.12, 20.26 -58.29, -43.12 280.16, 137.15 -98.94, 20.71 in-in in 7.628 Saltbr-in 2.858 HRD-in -87.93, -54.51 76.79, -4.02 in-out-in SNCioi out-in ActLoopNT-out 5.681 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.14, 131.04 APE9-dihe-in -114.33, 156.79 APE8-dihe-in -71.32, 89.5 APE8-rot-na 25.37 APE67-dihe-in -70.0, -11.6 -49.65, -44.27 APE12-dist-na 20.741 APE11-dist-na 16.009 APE10-dist-na 18.29 APE9-dist-in 7.277 Y393F,L445P None None XRAY 2.02 0.213 0.248 A 293 266 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK3B P00520 233 505 1123.0 SX7:2 Type1 Inactive DFGinter 8.654 4.762 None -66.35, 137.23 -141.11, 32.97 -68.57, -40.89 274.02, 151.63 -104.05, 31.43 in-in in 7.726 Saltbr-in 2.728 HRD-in -97.18, -55.69 76.9, -3.17 in-out-in SNCioi out-in ActLoopNT-out 5.554 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.31, 136.08 APE9-dihe-in -118.61, 148.91 APE8-dihe-in -68.85, 95.72 APE8-rot-na 24.23 APE67-dihe-in -70.92, -12.54 -48.57, -45.29 APE12-dist-na 19.212 APE11-dist-na 14.55 APE10-dist-na 17.621 APE9-dist-in 7.002 Y393F,L445P None None XRAY 2.02 0.213 0.248 B 293 269 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3K5VA P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.827 11.025 BBAminus -129.03, -178.81 -148.62, 103.08 -90.49, -4.28 302.25, 133.06 63.11, 53.01 in-in in 8.222 Saltbr-in 2.835 HRD-in -81.75, -55.21 87.7, -18.23 in-out-in SNCioi out-in ActLoopNT-out 16.369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.52, 121.82 APE9-dihe-in -113.18, 143.79 APE8-dihe-in -83.6, 88.45 APE8-rot-na 28.73 APE67-dihe-in -74.9, -7.51 -50.51, -43.0 APE12-dist-na 15.789 APE11-dist-na 11.692 APE10-dist-na 8.445 APE9-dist-in 7.78 None None None XRAY 1.74 0.201 0.231 A 293 281 1 0 0 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3K5VB P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.765 11.076 BBAminus -130.59, 178.94 -144.92, 105.3 -91.47, 1.18 305.46, 130.21 51.7, 50.11 in-in in 8.222 Saltbr-in 2.867 HRD-in -85.29, -53.14 86.12, -16.51 in-out-in SNCioi out-in ActLoopNT-out 16.402 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.28, 125.5 APE9-dihe-in -111.48, 141.99 APE8-dihe-in -82.96, 81.2 APE8-rot-na 29.67 APE67-dihe-in -69.06, -10.18 -42.49, -48.14 APE12-dist-na 15.584 APE11-dist-na 11.504 APE10-dist-na 8.598 APE9-dist-in 7.755 None None None XRAY 1.74 0.201 0.231 B 293 279 3 0 0 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD4A P00520 229 510 1123.0 FYW:60603,STI:60604 Allosteric,Type2 Inactive DFGout 13.776 10.935 BBAminus -130.79, -174.69 -153.04, 100.11 -89.33, 0.88 308.19, 134.35 53.16, 51.61 in-in in 8.114 Saltbr-in 2.871 HRD-in -79.72, -53.57 88.06, -19.16 in-out-in SNCioi out-in ActLoopNT-out 16.41 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.86, 116.72 APE9-dihe-in -109.35, 142.84 APE8-dihe-in -86.21, 87.25 APE8-rot-na 23.52 APE67-dihe-in -69.15, -11.0 -46.61, -47.58 APE12-dist-na 15.775 APE11-dist-na 11.79 APE10-dist-na 8.335 APE9-dist-in 7.859 None None None XRAY 2.03 0.183 0.223 A 293 281 1 0 0 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD4B P00520 229 510 1123.0 FYW:60601,STI:60602 Allosteric,Type2 Inactive DFGout 13.847 11.037 BBAminus -132.33, -177.63 -150.45, 101.55 -90.95, -0.99 307.99, 135.01 52.91, 55.37 in-in in 8.155 Saltbr-in 2.928 HRD-in -79.19, -55.7 86.14, -16.91 in-out-in SNCioi out-in ActLoopNT-out 16.524 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.49, 127.44 APE9-dihe-in -117.65, 140.28 APE8-dihe-in -83.09, 79.07 APE8-rot-na 27.61 APE67-dihe-in -65.5, -15.42 -38.27, -50.77 APE12-dist-na 15.565 APE11-dist-na 11.245 APE10-dist-na 8.371 APE9-dist-in 7.878 None None None XRAY 2.03 0.183 0.223 B 293 279 3 0 0 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD6A P00520 229 510 1123.0 FYH:60602,STI:60603 Allosteric,Type2 Inactive DFGout 13.788 10.899 BBAminus -118.54, -176.91 -146.68, 104.9 -90.05, -6.03 304.11, 138.72 66.96, 55.15 in-in in 8.295 Saltbr-in 2.815 HRD-in -88.34, -54.67 91.97, -25.73 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.42, 121.54 APE9-dihe-in -110.97, 144.39 APE8-dihe-in -82.04, 86.81 APE8-rot-na 32.54 APE67-dihe-in -76.73, -9.19 -49.14, -40.38 APE12-dist-na 15.643 APE11-dist-na 11.681 APE10-dist-na 8.157 APE9-dist-in 7.763 None None None XRAY 2.3 0.178 0.238 A 293 280 2 0 0 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3OY3A P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 12.947 9.007 BBAminus -137.29, -169.78 -157.65, 128.99 -111.75, 11.85 289.0, 94.91 50.98, 52.65 in-in in 7.867 Saltbr-in 2.989 HRD-in -74.78, -52.15 78.88, -9.23 in-out-in SNCioi out-in ActLoopNT-out 15.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.56, 121.47 APE9-dihe-in -112.4, 142.91 APE8-dihe-in -82.9, 85.53 APE8-rot-na 34.55 APE67-dihe-in -73.05, -8.51 -46.67, -46.08 APE12-dist-na 15.671 APE11-dist-na 11.549 APE10-dist-na 8.315 APE9-dist-in 7.926 T315I None None XRAY 1.95 0.22 0.266 A 284 283 0 0 0 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3OY3B P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 13.043 8.806 BBAminus -137.08, -175.15 -152.62, 125.15 -107.82, 7.08 288.46, 102.59 51.48, 58.3 in-in in 7.864 Saltbr-in 2.471 HRD-in -70.89, -52.75 81.95, -16.85 in-out-in SNCioi out-in ActLoopNT-out 15.74 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.39, 125.75 APE9-dihe-in -114.93, 142.91 APE8-dihe-in -80.63, 91.02 APE8-rot-na 31.59 APE67-dihe-in -73.68, -7.56 -52.87, -45.41 APE12-dist-na 15.729 APE11-dist-na 11.525 APE10-dist-na 8.266 APE9-dist-in 7.988 T315I None None XRAY 1.95 0.22 0.266 B 284 283 0 0 0 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.504 9.438 BBAminus -139.29, -179.88 -153.49, 108.65 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.538 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.01 APE11-dist-na 11.84 APE10-dist-na 8.456 APE9-dist-in 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288 279 6 0 0 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.498 9.17 BBAminus -129.46, 178.53 -148.47, 114.27 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.992 Saltbr-in 2.655 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.826 APE11-dist-na 11.596 APE10-dist-na 8.603 APE9-dist-in 7.851 T315I None None XRAY 1.9 0.216 0.258 B 288 285 0 0 0 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.316 8.94 BBAminus -130.11, -171.24 -154.37, 127.79 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.004 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.377 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-out 8.088 None None None XRAY 2.2 0.218 0.261 A 284 267 16 0 0 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KFAA P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.244 8.82 BBAminus -142.27, -176.56 -152.63, 125.74 -107.34, 5.74 288.91, 88.99 58.04, 50.09 in-in in 8.14 Saltbr-in 2.717 HRD-in -73.85, -48.11 82.13, -13.17 in-out-in SNCioi out-in ActLoopNT-out 15.64 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.63, 125.03 APE9-dihe-in -114.41, 145.91 APE8-dihe-in -84.21, 85.96 APE8-rot-na 33.66 APE67-dihe-in -73.3, -8.53 -52.44, -41.01 APE12-dist-na 15.803 APE11-dist-na 11.654 APE10-dist-na 8.666 APE9-dist-in 7.713 None None None XRAY 1.22 0.201 0.201 A 288 283 0 0 0 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KFAB P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.255 8.805 BBAminus -140.52, -176.97 -152.37, 125.18 -106.35, 4.72 288.28, 89.94 58.68, 49.29 in-in in 8.137 Saltbr-in 2.692 HRD-in -74.33, -47.79 81.87, -12.97 in-out-in SNCioi out-in ActLoopNT-out 15.604 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.66, 126.45 APE9-dihe-in -115.84, 145.74 APE8-dihe-in -82.6, 85.95 APE8-rot-na 33.9 APE67-dihe-in -74.2, -7.78 -53.04, -40.32 APE12-dist-na 15.789 APE11-dist-na 11.659 APE10-dist-na 8.704 APE9-dist-in 7.698 None None None XRAY 1.22 0.201 0.201 B 288 283 0 0 0 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1FPUA P00520 229 499 1123.0 PRC:60001 Type2 Inactive DFGout 13.418 10.949 BBAminus -141.9, -166.28 -158.13, 103.8 -90.94, 3.8 310.97, 131.54 54.26, 50.94 in-in in 8.403 Saltbr-in 2.871 HRD-in -86.77, -50.24 77.96, -12.71 in-out-in SNCioi out-in ActLoopNT-out 16.225 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.73, 138.95 APE9-dihe-in -131.33, 134.86 APE8-dihe-in -81.8, 82.67 APE8-rot-na 35.36 APE67-dihe-in -73.73, -7.55 -41.73, -44.76 APE12-dist-na 14.113 APE11-dist-na 12.254 APE10-dist-na 8.14 APE9-dist-in 7.442 None None None XRAY 2.4 0.239 0.264 A 293 271 0 0 0 0 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1FPUB P00520 229 499 1123.0 PRC:60002 Type2 Inactive DFGout 13.509 10.529 BBAminus -141.62, -165.58 -158.88, 104.33 -91.66, 4.75 310.99, 131.8 53.0, 51.49 in-in in 8.316 Saltbr-in 3.059 HRD-in -85.61, -50.1 76.84, -10.82 in-out-in SNCioi out-in ActLoopNT-out 16.231 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.53, 139.19 APE9-dihe-in -131.35, 134.07 APE8-dihe-in -80.76, 81.97 APE8-rot-na 34.87 APE67-dihe-in -70.5, -12.0 -41.07, -44.99 APE12-dist-na 14.107 APE11-dist-na 12.255 APE10-dist-na 8.136 APE9-dist-in 7.45 None None None XRAY 2.4 0.239 0.264 B 293 266 5 0 0 5 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1IEPA P00520 229 498 1123.0 STI:60201 Type2 Inactive DFGout 13.562 10.861 BBAminus -137.03, -172.54 -153.96, 97.64 -87.18, 3.68 308.79, 136.8 52.65, 57.65 in-in in 8.311 Saltbr-in 3.102 HRD-in -76.11, -58.44 87.76, -16.49 in-out-in SNCioi out-in ActLoopNT-out 16.321 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.61, 141.98 APE9-dihe-in -135.62, 143.41 APE8-dihe-in -82.32, 86.58 APE8-rot-na 35.1 APE67-dihe-in -73.95, -4.51 -43.85, -43.13 APE12-dist-na 14.642 APE11-dist-na 11.799 APE10-dist-na 8.489 APE9-dist-in 7.34 None None None XRAY 2.1 0.231 0.262 A 293 270 0 0 0 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1IEPB P00520 229 498 1123.0 STI:60202 Type2 Inactive DFGout 13.529 10.801 BBAminus -143.94, -178.65 -148.11, 93.74 -82.6, -2.47 307.48, 137.57 62.07, 48.88 in-out in 8.185 Saltbr-out 4.368 HRD-in -84.56, -56.22 87.89, -19.72 out-out-in SNCooi out-in ActLoopNT-out 14.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.54, 140.59 APE9-dihe-in -139.53, 149.49 APE8-dihe-in -85.03, 86.81 APE8-rot-na 36.13 APE67-dihe-in -68.22, -7.81 -42.13, -46.9 APE12-dist-na 15.693 APE11-dist-na 11.543 APE10-dist-na 8.671 APE9-dist-in 7.199 None None None XRAY 2.1 0.231 0.262 B 293 270 0 0 0 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1OPJA P00520 229 510 1123.0 STI:60003 Type2 Inactive DFGout 13.78 10.826 BBAminus -128.07, -174.54 -152.92, 98.6 -89.13, 6.29 307.36, 137.21 49.4, 56.53 in-in in 8.262 Saltbr-in 2.683 HRD-in -85.47, -54.47 85.47, -15.74 in-out-out SNCioo out-out ActLoopNT-out 16.138 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -110.59, 111.76 APE9-dihe-in -105.57, 139.7 APE8-dihe-in -87.32, 84.08 APE8-rot-na 31.83 APE67-dihe-in -67.58, -10.57 -46.59, -43.84 APE12-dist-na 15.813 APE11-dist-na 11.632 APE10-dist-na 8.46 APE9-dist-out 8.091 None None None XRAY 1.75 0.21 0.242 A 293 282 0 0 0 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1OPJB P00520 229 512 1123.0 STI:60004 Type2 Inactive DFGout 13.911 11.321 BBAminus -132.18, -179.0 -150.37, 98.45 -86.36, 2.32 310.86, 130.49 52.69, 56.75 in-in in 8.055 Saltbr-in 2.881 HRD-in -79.51, -55.82 87.48, -17.62 in-out-in SNCioi out-in ActLoopNT-out 16.164 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.86, 121.43 APE9-dihe-in -116.41, 142.51 APE8-dihe-in -88.15, 80.96 APE8-rot-na 32.33 APE67-dihe-in -69.25, -7.13 -40.7, -49.19 APE12-dist-na 15.79 APE11-dist-na 11.833 APE10-dist-na 8.395 APE9-dist-in 7.806 None None None XRAY 1.75 0.21 0.242 B 293 284 0 0 0 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 2HZNA P00520 229 502 1123.0 KIN:60600 Type2 Inactive DFGout 14.958 9.672 BBAminus -139.88, -164.81 -155.74, 124.37 -98.42, -30.89 272.45, 94.35 80.92, 43.41 in-in in 8.161 Saltbr-in 2.576 HRD-in -62.12, -53.83 87.41, -26.87 in-out-in SNCioi out-in ActLoopNT-out 16.163 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.47, 150.88 APE9-dihe-in -140.18, 135.21 APE8-dihe-in -65.94, 87.96 APE8-rot-na 341.9 APE67-dihe-in -68.13, -18.79 -49.49, -50.03 APE12-dist-na 15.039 APE11-dist-na 10.614 APE10-dist-na 8.582 APE9-dist-in 7.317 None None None XRAY 2.7 0.267 0.314 A 293 269 5 0 0 0 [[242, 495]] 1.0 2hzn Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD6B P00520 229 510 1123.0 STI:60601 Type2 Inactive DFGout 13.829 11.179 BBAminus -125.12, -175.5 -154.19, 103.09 -91.96, 21.1 310.97, 128.7 31.22, 64.2 in-in in 8.394 Saltbr-in 3.072 HRD-in -85.22, -51.46 85.37, -17.4 in-out-in SNCioi out-in ActLoopNT-out 16.369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.94, 122.32 APE9-dihe-in -101.91, 149.19 APE8-dihe-in -81.38, 82.15 APE8-rot-na 19.67 APE67-dihe-in -78.93, -7.66 -49.97, -39.1 APE12-dist-na 15.412 APE11-dist-na 11.178 APE10-dist-na 8.764 APE9-dist-in 7.782 None None None XRAY 2.3 0.178 0.238 B 293 279 3 0 0 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MS9A P00520 230 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.66 10.992 BBAminus -129.69, -177.84 -146.05, 100.92 -85.37, -0.41 305.07, 135.33 63.76, 47.34 in-in in 8.341 Saltbr-in 3.153 HRD-in -79.52, -52.27 83.07, -15.37 in-out-in SNCioi out-in ActLoopNT-out 16.086 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.38, 129.78 APE9-dihe-in -118.07, 145.91 APE8-dihe-in -88.08, 91.81 APE8-rot-na 29.01 APE67-dihe-in -75.19, -6.62 -50.02, -40.18 APE12-dist-na 14.363 APE11-dist-na 12.22 APE10-dist-na 8.639 APE9-dist-in 7.532 None None None XRAY 1.8 0.188 0.234 A 293 261 8 0 0 2 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MS9B P00520 229 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.648 10.944 BBAminus -132.64, -179.46 -143.9, 102.88 -90.37, 5.1 303.67, 135.83 60.73, 51.4 in-in in 8.292 Saltbr-in 2.781 HRD-in -83.7, -52.15 86.58, -11.15 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.02, 135.09 APE9-dihe-in -128.33, 142.16 APE8-dihe-in -86.14, 87.78 APE8-rot-na 36.31 APE67-dihe-in -76.28, -2.93 -48.89, -43.33 APE12-dist-na 15.591 APE11-dist-na 13.452 APE10-dist-na 8.856 APE9-dist-in 7.628 None None None XRAY 1.8 0.188 0.234 B 293 267 3 0 0 0 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSA P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.602 10.927 BBAminus -140.22, -178.36 -147.69, 104.27 -89.71, -2.47 299.0, 139.73 66.29, 43.35 in-in in 8.389 Saltbr-in 3.095 HRD-in -74.19, -56.0 83.94, -13.58 in-out-in SNCioi out-in ActLoopNT-out 16.219 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.21, 134.82 APE9-dihe-in -123.76, 144.56 APE8-dihe-in -89.25, 91.24 APE8-rot-na 26.73 APE67-dihe-in -76.81, -6.98 -52.23, -37.7 APE12-dist-na 14.446 APE11-dist-na 11.974 APE10-dist-na 8.581 APE9-dist-in 7.441 None None None XRAY 1.95 0.172 0.22 A 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSB P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.6 10.82 BBAminus -134.26, 179.26 -142.74, 100.94 -88.95, 3.79 301.55, 135.44 59.27, 50.16 in-in in 8.188 Saltbr-in 2.729 HRD-in -84.32, -52.44 85.34, -18.42 in-out-in SNCioi out-in ActLoopNT-out 15.326 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.6, 137.91 APE9-dihe-in -132.77, 140.13 APE8-dihe-in -80.01, 89.25 APE8-rot-na 23.44 APE67-dihe-in -77.65, -10.14 -50.83, -40.78 APE12-dist-na 15.576 APE11-dist-na 13.486 APE10-dist-na 8.8 APE9-dist-in 7.455 None None None XRAY 1.95 0.172 0.22 B 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSC P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.591 10.963 BBAminus -138.8, 179.7 -144.18, 103.21 -86.54, 1.5 302.89, 134.71 58.1, 46.5 in-in in 8.088 Saltbr-in 3.047 HRD-in -78.89, -57.09 86.43, -17.08 in-out-in SNCioi out-in ActLoopNT-out 16.108 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.32, 131.91 APE9-dihe-in -126.48, 145.59 APE8-dihe-in -89.99, 90.94 APE8-rot-na 26.3 APE67-dihe-in -77.37, -6.31 -51.14, -38.56 APE12-dist-na 14.594 APE11-dist-na 11.85 APE10-dist-na 8.463 APE9-dist-in 7.442 None None None XRAY 1.95 0.172 0.22 C 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSD P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.547 10.788 BBAminus -134.13, -175.99 -148.24, 101.28 -89.17, 5.19 302.32, 137.83 56.24, 49.56 in-in in 8.192 Saltbr-in 2.789 HRD-in -83.98, -55.12 89.03, -15.39 in-out-in SNCioi out-in ActLoopNT-out 15.539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.05, 133.37 APE9-dihe-in -131.92, 141.87 APE8-dihe-in -80.66, 89.72 APE8-rot-na 31.84 APE67-dihe-in -74.69, -8.69 -52.73, -42.14 APE12-dist-na 15.622 APE11-dist-na 13.606 APE10-dist-na 8.783 APE9-dist-in 7.554 None None None XRAY 1.95 0.172 0.22 D 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1M52A P00520 232 502 1123.0 P17:119 Type1.5_Back Inactive DFGout 12.793 10.753 None -60.22, 138.56 -89.44, -13.76 -71.29, 150.54 62.03, 63.6 85.22, 23.45 in-in in 7.895 Saltbr-in 2.707 HRD-out -103.5, 129.11 -84.41, -9.26 in-out-in SNCioi out-in ActLoopNT-out 5.523 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.32, 126.97 APE9-dihe-in -125.58, 158.53 APE8-dihe-in -60.22, 106.23 APE8-rot-na 28.98 APE67-dihe-in -61.13, -15.48 -48.91, -53.77 APE12-dist-na 18.536 APE11-dist-na 14.052 APE10-dist-na 17.1 APE9-dist-in 6.34 None None None XRAY 2.6 0.211 0.254 A 293 271 0 0 0 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1M52B P00520 232 503 1123.0 P17:120 Type1.5_Back Inactive DFGout 12.781 10.997 None -67.54, 135.07 -84.58, -12.33 -70.24, 151.37 63.17, 66.62 85.76, 18.68 in-in in 8.096 Saltbr-in 2.823 HRD-out -106.35, 123.08 -78.82, -9.36 in-out-in SNCioi out-in ActLoopNT-out 5.579 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.32, 130.43 APE9-dihe-in -127.38, 164.85 APE8-dihe-in -67.06, 104.95 APE8-rot-na 28.73 APE67-dihe-in -58.93, -14.72 -46.9, -55.31 APE12-dist-na 18.942 APE11-dist-na 14.182 APE10-dist-na 17.032 APE9-dist-in 6.37 None None None XRAY 2.6 0.211 0.254 B 293 272 0 0 0 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1OPKA P00520 64 512 1123.0 P16:60002 Type1.5_Back Inactive DFGout 12.853 11.524 None -65.37, 134.02 -116.02, 33.5 -83.75, 159.92 53.06, 70.43 67.02, 7.91 in-in in 7.957 Saltbr-in 2.94 HRD-in -97.25, -54.03 73.87, -6.88 in-out-in SNCioi out-in ActLoopNT-out 5.558 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.1, 127.8 APE9-dihe-in -117.64, 161.56 APE8-dihe-in -80.21, 93.15 APE8-rot-na 30.65 APE67-dihe-in -63.48, -19.22 -41.98, -48.41 APE12-dist-na 19.48 APE11-dist-na 14.753 APE10-dist-na 17.431 APE9-dist-in 7.125 D363N None None XRAY 1.8 0.196 0.221 A 495 449 0 0 0 0 [[242, 495]] 1.0 1opk Mus musculus TYR_ABL1_MOUSE TYR 5.5e-99 337.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK7B P00520 233 505 1123.0 SX7:2 Type1 Inactive None 999.0 999.0 None -70.09, 131.91 -99.1, 30.92 -47.67, -78.64 999.0, 999.0 -116.53, 59.69 in-none in 8.153 Saltbr-none 999.0 HRD-in -96.35, -57.33 75.78, -1.22 none-out-in SNCnoi out-in ActLoopNT-out 5.635 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.0, 138.44 APE9-dihe-in -123.96, 150.21 APE8-dihe-in -64.33, 99.33 APE8-rot-na 21.28 APE67-dihe-in -72.95, -10.57 -50.9, -44.43 APE12-dist-na 19.136 APE11-dist-na 14.483 APE10-dist-na 17.474 APE9-dist-in 7.019 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 B 277 269 4 0 0 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

TYR_ABL1 (Tyrosine-protein kinase ABL1)

Total number of chains: 40
Active chains: 5
Family: TYR
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 26 65.0% 3KFAA
DFGin BLAminus 5 12.5% 3KF4B
DFGinter None 5 12.5% 3DK7A
DFGout None 3 7.5% 1OPKA
None None 1 2.5% 3DK7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL1_MOUSE 2Z60A P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.849 13.481 BLAminus -137.02, -172.04 59.64, 81.83 -96.6, 21.67 303.76, 107.0 -57.3, -29.84 in-in in 7.709 Saltbr-in 2.641 HRD-in -89.4, -48.82 73.73, 3.17 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.81, 154.38 APE9-dihe-in -134.15, 168.28 APE8-dihe-in -62.25, 96.21 APE8-rot-na 339.53 APE67-dihe-in -71.21, -15.43 -42.73, -46.48 APE12-dist-na 15.564 APE11-dist-na 10.729 APE10-dist-na 13.421 APE9-dist-in 7.263 T315I None None XRAY 1.95 0.206 0.245 A 288 280 3 0 0 0 [[242, 495]] 1.0 2z60 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 2QOHA P00520 229 501 1123.0 P3Y:60001 Type1 Active DFGin 6.792 13.3 BLAminus -137.18, -173.6 58.31, 89.23 -103.73, 22.71 305.14, 99.76 -56.65, -30.84 in-in in 7.833 Saltbr-in 2.648 HRD-in -86.16, -51.73 78.16, -1.08 in-in-in SNCiii in-in ActLoopNT-in 3.171 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.12, 148.82 APE9-dihe-in -123.25, 167.08 APE8-dihe-in -79.06, 86.62 APE8-rot-na 341.05 APE67-dihe-in -62.47, -15.79 -35.13, -54.47 APE12-dist-na 15.229 APE11-dist-na 10.546 APE10-dist-na 13.183 APE9-dist-in 7.319 None None None XRAY 1.95 0.214 0.255 A 288 270 3 0 0 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 2QOHB P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.954 13.03 BLAminus -146.85, -174.9 61.51, 81.39 -99.78, 25.49 304.24, 93.09 -56.89, -22.43 in-in in 7.883 Saltbr-in 2.721 HRD-in -91.49, -48.67 74.38, 6.2 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.22, 145.99 APE9-dihe-in -127.49, 165.6 APE8-dihe-in -83.22, 84.35 APE8-rot-na 349.39 APE67-dihe-in -72.21, -14.36 -35.43, -45.09 APE12-dist-na 15.247 APE11-dist-na 10.505 APE10-dist-na 12.838 APE9-dist-in 7.4 None None None XRAY 1.95 0.214 0.255 B 288 280 3 0 0 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KF4A P00520 229 514 1123.0 B90:1 Type1.5_Back Active DFGin 6.717 13.487 BLAminus -138.47, -169.78 64.32, 74.67 -103.01, 17.52 308.56, 103.02 -57.24, -29.09 in-in in 8.038 Saltbr-in 2.842 HRD-in -97.68, -52.38 80.64, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 154.17 APE9-dihe-in -130.7, 158.73 APE8-dihe-in -75.38, 102.27 APE8-rot-na 27.21 APE67-dihe-in -74.45, -9.72 -55.5, -39.82 APE12-dist-na 14.483 APE11-dist-na 10.063 APE10-dist-na 13.048 APE9-dist-in 7.316 None None None XRAY 1.9 0.197 0.24 A 288 281 5 0 0 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KF4B P00520 229 501 1123.0 B90:1 Type1.5_Back Active DFGin 6.673 13.649 BLAminus -131.98, -172.92 66.04, 78.12 -105.54, 16.69 306.01, 100.01 -53.92, -33.68 in-in in 8.099 Saltbr-in 2.87 HRD-in -96.09, -52.11 78.87, 6.97 in-in-in SNCiii in-in ActLoopNT-in 2.937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.63, 136.23 APE9-dihe-in -115.19, 156.97 APE8-dihe-in -69.24, 107.22 APE8-rot-na 26.84 APE67-dihe-in -70.3, -19.91 -54.93, -42.84 APE12-dist-na 15.155 APE11-dist-na 10.396 APE10-dist-na 13.206 APE9-dist-in 7.469 None None None XRAY 1.9 0.197 0.24 B 288 270 3 0 0 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK7A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.521 4.47 None -65.94, 133.62 -136.37, 26.36 -59.29, -46.94 277.65, 138.09 -96.98, 21.57 in-in in 7.766 Saltbr-in 2.793 HRD-in -90.33, -58.06 79.79, -1.99 in-out-in SNCioi out-in ActLoopNT-out 5.675 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.5, 130.75 APE9-dihe-in -114.11, 153.09 APE8-dihe-in -69.74, 90.62 APE8-rot-na 25.02 APE67-dihe-in -72.01, -11.59 -51.31, -42.54 APE12-dist-na 20.579 APE11-dist-na 15.929 APE10-dist-na 18.225 APE9-dist-in 7.447 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 A 277 266 4 0 0 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK6A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.835 8.306 None -61.57, 128.5 -127.52, 27.29 -83.26, -21.75 331.68, 119.16 -112.49, 27.73 in-in in 7.974 Saltbr-in 2.893 HRD-in -91.42, -55.08 73.35, 1.27 in-out-in SNCioi out-in ActLoopNT-out 5.66 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.77, 134.59 APE9-dihe-in -117.57, 154.09 APE8-dihe-in -69.69, 91.12 APE8-rot-na 24.6 APE67-dihe-in -73.26, -8.23 -48.64, -44.69 APE12-dist-na 20.525 APE11-dist-na 15.941 APE10-dist-na 18.171 APE9-dist-in 7.39 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 A 293 263 7 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK6B P00520 234 505 1123.0 SX7:2 Type1 Inactive DFGinter 9.607 8.211 None -63.13, 129.74 -127.1, 39.65 -91.94, -7.89 322.45, 123.44 -137.52, 35.5 in-none in 8.477 Saltbr-none 999.0 HRD-in -90.89, -55.29 76.04, -7.16 none-out-in SNCnoi out-in ActLoopNT-out 5.58 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.73, 139.41 APE9-dihe-in -127.03, 148.23 APE8-dihe-in -65.18, 97.87 APE8-rot-na 342.63 APE67-dihe-in -74.45, -10.42 -49.61, -43.27 APE12-dist-na 18.841 APE11-dist-na 14.184 APE10-dist-na 17.301 APE9-dist-in 6.943 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 B 293 260 12 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK3A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.037 4.534 None -66.29, 133.89 -136.12, 20.26 -58.29, -43.12 280.16, 137.15 -98.94, 20.71 in-in in 7.628 Saltbr-in 2.858 HRD-in -87.93, -54.51 76.79, -4.02 in-out-in SNCioi out-in ActLoopNT-out 5.681 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.14, 131.04 APE9-dihe-in -114.33, 156.79 APE8-dihe-in -71.32, 89.5 APE8-rot-na 25.37 APE67-dihe-in -70.0, -11.6 -49.65, -44.27 APE12-dist-na 20.741 APE11-dist-na 16.009 APE10-dist-na 18.29 APE9-dist-in 7.277 Y393F,L445P None None XRAY 2.02 0.213 0.248 A 293 266 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK3B P00520 233 505 1123.0 SX7:2 Type1 Inactive DFGinter 8.654 4.762 None -66.35, 137.23 -141.11, 32.97 -68.57, -40.89 274.02, 151.63 -104.05, 31.43 in-in in 7.726 Saltbr-in 2.728 HRD-in -97.18, -55.69 76.9, -3.17 in-out-in SNCioi out-in ActLoopNT-out 5.554 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.31, 136.08 APE9-dihe-in -118.61, 148.91 APE8-dihe-in -68.85, 95.72 APE8-rot-na 24.23 APE67-dihe-in -70.92, -12.54 -48.57, -45.29 APE12-dist-na 19.212 APE11-dist-na 14.55 APE10-dist-na 17.621 APE9-dist-in 7.002 Y393F,L445P None None XRAY 2.02 0.213 0.248 B 293 269 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3K5VA P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.827 11.025 BBAminus -129.03, -178.81 -148.62, 103.08 -90.49, -4.28 302.25, 133.06 63.11, 53.01 in-in in 8.222 Saltbr-in 2.835 HRD-in -81.75, -55.21 87.7, -18.23 in-out-in SNCioi out-in ActLoopNT-out 16.369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.52, 121.82 APE9-dihe-in -113.18, 143.79 APE8-dihe-in -83.6, 88.45 APE8-rot-na 28.73 APE67-dihe-in -74.9, -7.51 -50.51, -43.0 APE12-dist-na 15.789 APE11-dist-na 11.692 APE10-dist-na 8.445 APE9-dist-in 7.78 None None None XRAY 1.74 0.201 0.231 A 293 281 1 0 0 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3K5VB P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.765 11.076 BBAminus -130.59, 178.94 -144.92, 105.3 -91.47, 1.18 305.46, 130.21 51.7, 50.11 in-in in 8.222 Saltbr-in 2.867 HRD-in -85.29, -53.14 86.12, -16.51 in-out-in SNCioi out-in ActLoopNT-out 16.402 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.28, 125.5 APE9-dihe-in -111.48, 141.99 APE8-dihe-in -82.96, 81.2 APE8-rot-na 29.67 APE67-dihe-in -69.06, -10.18 -42.49, -48.14 APE12-dist-na 15.584 APE11-dist-na 11.504 APE10-dist-na 8.598 APE9-dist-in 7.755 None None None XRAY 1.74 0.201 0.231 B 293 279 3 0 0 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD4A P00520 229 510 1123.0 FYW:60603,STI:60604 Allosteric,Type2 Inactive DFGout 13.776 10.935 BBAminus -130.79, -174.69 -153.04, 100.11 -89.33, 0.88 308.19, 134.35 53.16, 51.61 in-in in 8.114 Saltbr-in 2.871 HRD-in -79.72, -53.57 88.06, -19.16 in-out-in SNCioi out-in ActLoopNT-out 16.41 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.86, 116.72 APE9-dihe-in -109.35, 142.84 APE8-dihe-in -86.21, 87.25 APE8-rot-na 23.52 APE67-dihe-in -69.15, -11.0 -46.61, -47.58 APE12-dist-na 15.775 APE11-dist-na 11.79 APE10-dist-na 8.335 APE9-dist-in 7.859 None None None XRAY 2.03 0.183 0.223 A 293 281 1 0 0 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD4B P00520 229 510 1123.0 FYW:60601,STI:60602 Allosteric,Type2 Inactive DFGout 13.847 11.037 BBAminus -132.33, -177.63 -150.45, 101.55 -90.95, -0.99 307.99, 135.01 52.91, 55.37 in-in in 8.155 Saltbr-in 2.928 HRD-in -79.19, -55.7 86.14, -16.91 in-out-in SNCioi out-in ActLoopNT-out 16.524 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.49, 127.44 APE9-dihe-in -117.65, 140.28 APE8-dihe-in -83.09, 79.07 APE8-rot-na 27.61 APE67-dihe-in -65.5, -15.42 -38.27, -50.77 APE12-dist-na 15.565 APE11-dist-na 11.245 APE10-dist-na 8.371 APE9-dist-in 7.878 None None None XRAY 2.03 0.183 0.223 B 293 279 3 0 0 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD6A P00520 229 510 1123.0 FYH:60602,STI:60603 Allosteric,Type2 Inactive DFGout 13.788 10.899 BBAminus -118.54, -176.91 -146.68, 104.9 -90.05, -6.03 304.11, 138.72 66.96, 55.15 in-in in 8.295 Saltbr-in 2.815 HRD-in -88.34, -54.67 91.97, -25.73 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.42, 121.54 APE9-dihe-in -110.97, 144.39 APE8-dihe-in -82.04, 86.81 APE8-rot-na 32.54 APE67-dihe-in -76.73, -9.19 -49.14, -40.38 APE12-dist-na 15.643 APE11-dist-na 11.681 APE10-dist-na 8.157 APE9-dist-in 7.763 None None None XRAY 2.3 0.178 0.238 A 293 280 2 0 0 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3OY3A P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 12.947 9.007 BBAminus -137.29, -169.78 -157.65, 128.99 -111.75, 11.85 289.0, 94.91 50.98, 52.65 in-in in 7.867 Saltbr-in 2.989 HRD-in -74.78, -52.15 78.88, -9.23 in-out-in SNCioi out-in ActLoopNT-out 15.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.56, 121.47 APE9-dihe-in -112.4, 142.91 APE8-dihe-in -82.9, 85.53 APE8-rot-na 34.55 APE67-dihe-in -73.05, -8.51 -46.67, -46.08 APE12-dist-na 15.671 APE11-dist-na 11.549 APE10-dist-na 8.315 APE9-dist-in 7.926 T315I None None XRAY 1.95 0.22 0.266 A 284 283 0 0 0 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3OY3B P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 13.043 8.806 BBAminus -137.08, -175.15 -152.62, 125.15 -107.82, 7.08 288.46, 102.59 51.48, 58.3 in-in in 7.864 Saltbr-in 2.471 HRD-in -70.89, -52.75 81.95, -16.85 in-out-in SNCioi out-in ActLoopNT-out 15.74 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.39, 125.75 APE9-dihe-in -114.93, 142.91 APE8-dihe-in -80.63, 91.02 APE8-rot-na 31.59 APE67-dihe-in -73.68, -7.56 -52.87, -45.41 APE12-dist-na 15.729 APE11-dist-na 11.525 APE10-dist-na 8.266 APE9-dist-in 7.988 T315I None None XRAY 1.95 0.22 0.266 B 284 283 0 0 0 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.504 9.438 BBAminus -139.29, -179.88 -153.49, 108.65 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.538 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.01 APE11-dist-na 11.84 APE10-dist-na 8.456 APE9-dist-in 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288 279 6 0 0 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.498 9.17 BBAminus -129.46, 178.53 -148.47, 114.27 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.992 Saltbr-in 2.655 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.703 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.826 APE11-dist-na 11.596 APE10-dist-na 8.603 APE9-dist-in 7.851 T315I None None XRAY 1.9 0.216 0.258 B 288 285 0 0 0 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.316 8.94 BBAminus -130.11, -171.24 -154.37, 127.79 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.004 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.377 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-out 8.088 None None None XRAY 2.2 0.218 0.261 A 284 267 16 0 0 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KFAA P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.244 8.82 BBAminus -142.27, -176.56 -152.63, 125.74 -107.34, 5.74 288.91, 88.99 58.04, 50.09 in-in in 8.14 Saltbr-in 2.717 HRD-in -73.85, -48.11 82.13, -13.17 in-out-in SNCioi out-in ActLoopNT-out 15.64 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.63, 125.03 APE9-dihe-in -114.41, 145.91 APE8-dihe-in -84.21, 85.96 APE8-rot-na 33.66 APE67-dihe-in -73.3, -8.53 -52.44, -41.01 APE12-dist-na 15.803 APE11-dist-na 11.654 APE10-dist-na 8.666 APE9-dist-in 7.713 None None None XRAY 1.22 0.201 0.201 A 288 283 0 0 0 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3KFAB P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.255 8.805 BBAminus -140.52, -176.97 -152.37, 125.18 -106.35, 4.72 288.28, 89.94 58.68, 49.29 in-in in 8.137 Saltbr-in 2.692 HRD-in -74.33, -47.79 81.87, -12.97 in-out-in SNCioi out-in ActLoopNT-out 15.604 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.66, 126.45 APE9-dihe-in -115.84, 145.74 APE8-dihe-in -82.6, 85.95 APE8-rot-na 33.9 APE67-dihe-in -74.2, -7.78 -53.04, -40.32 APE12-dist-na 15.789 APE11-dist-na 11.659 APE10-dist-na 8.704 APE9-dist-in 7.698 None None None XRAY 1.22 0.201 0.201 B 288 283 0 0 0 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1FPUA P00520 229 499 1123.0 PRC:60001 Type2 Inactive DFGout 13.418 10.949 BBAminus -141.9, -166.28 -158.13, 103.8 -90.94, 3.8 310.97, 131.54 54.26, 50.94 in-in in 8.403 Saltbr-in 2.871 HRD-in -86.77, -50.24 77.96, -12.71 in-out-in SNCioi out-in ActLoopNT-out 16.225 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.73, 138.95 APE9-dihe-in -131.33, 134.86 APE8-dihe-in -81.8, 82.67 APE8-rot-na 35.36 APE67-dihe-in -73.73, -7.55 -41.73, -44.76 APE12-dist-na 14.113 APE11-dist-na 12.254 APE10-dist-na 8.14 APE9-dist-in 7.442 None None None XRAY 2.4 0.239 0.264 A 293 271 0 0 0 0 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1FPUB P00520 229 499 1123.0 PRC:60002 Type2 Inactive DFGout 13.509 10.529 BBAminus -141.62, -165.58 -158.88, 104.33 -91.66, 4.75 310.99, 131.8 53.0, 51.49 in-in in 8.316 Saltbr-in 3.059 HRD-in -85.61, -50.1 76.84, -10.82 in-out-in SNCioi out-in ActLoopNT-out 16.231 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.53, 139.19 APE9-dihe-in -131.35, 134.07 APE8-dihe-in -80.76, 81.97 APE8-rot-na 34.87 APE67-dihe-in -70.5, -12.0 -41.07, -44.99 APE12-dist-na 14.107 APE11-dist-na 12.255 APE10-dist-na 8.136 APE9-dist-in 7.45 None None None XRAY 2.4 0.239 0.264 B 293 266 5 0 0 5 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1IEPA P00520 229 498 1123.0 STI:60201 Type2 Inactive DFGout 13.562 10.861 BBAminus -137.03, -172.54 -153.96, 97.64 -87.18, 3.68 308.79, 136.8 52.65, 57.65 in-in in 8.311 Saltbr-in 3.102 HRD-in -76.11, -58.44 87.76, -16.49 in-out-in SNCioi out-in ActLoopNT-out 16.321 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.61, 141.98 APE9-dihe-in -135.62, 143.41 APE8-dihe-in -82.32, 86.58 APE8-rot-na 35.1 APE67-dihe-in -73.95, -4.51 -43.85, -43.13 APE12-dist-na 14.642 APE11-dist-na 11.799 APE10-dist-na 8.489 APE9-dist-in 7.34 None None None XRAY 2.1 0.231 0.262 A 293 270 0 0 0 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1IEPB P00520 229 498 1123.0 STI:60202 Type2 Inactive DFGout 13.529 10.801 BBAminus -143.94, -178.65 -148.11, 93.74 -82.6, -2.47 307.48, 137.57 62.07, 48.88 in-out in 8.185 Saltbr-out 4.368 HRD-in -84.56, -56.22 87.89, -19.72 out-out-in SNCooi out-in ActLoopNT-out 14.972 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.54, 140.59 APE9-dihe-in -139.53, 149.49 APE8-dihe-in -85.03, 86.81 APE8-rot-na 36.13 APE67-dihe-in -68.22, -7.81 -42.13, -46.9 APE12-dist-na 15.693 APE11-dist-na 11.543 APE10-dist-na 8.671 APE9-dist-in 7.199 None None None XRAY 2.1 0.231 0.262 B 293 270 0 0 0 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1OPJA P00520 229 510 1123.0 STI:60003 Type2 Inactive DFGout 13.78 10.826 BBAminus -128.07, -174.54 -152.92, 98.6 -89.13, 6.29 307.36, 137.21 49.4, 56.53 in-in in 8.262 Saltbr-in 2.683 HRD-in -85.47, -54.47 85.47, -15.74 in-out-out SNCioo out-out ActLoopNT-out 16.138 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -110.59, 111.76 APE9-dihe-in -105.57, 139.7 APE8-dihe-in -87.32, 84.08 APE8-rot-na 31.83 APE67-dihe-in -67.58, -10.57 -46.59, -43.84 APE12-dist-na 15.813 APE11-dist-na 11.632 APE10-dist-na 8.46 APE9-dist-out 8.091 None None None XRAY 1.75 0.21 0.242 A 293 282 0 0 0 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1OPJB P00520 229 512 1123.0 STI:60004 Type2 Inactive DFGout 13.911 11.321 BBAminus -132.18, -179.0 -150.37, 98.45 -86.36, 2.32 310.86, 130.49 52.69, 56.75 in-in in 8.055 Saltbr-in 2.881 HRD-in -79.51, -55.82 87.48, -17.62 in-out-in SNCioi out-in ActLoopNT-out 16.164 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.86, 121.43 APE9-dihe-in -116.41, 142.51 APE8-dihe-in -88.15, 80.96 APE8-rot-na 32.33 APE67-dihe-in -69.25, -7.13 -40.7, -49.19 APE12-dist-na 15.79 APE11-dist-na 11.833 APE10-dist-na 8.395 APE9-dist-in 7.806 None None None XRAY 1.75 0.21 0.242 B 293 284 0 0 0 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 2HZNA P00520 229 502 1123.0 KIN:60600 Type2 Inactive DFGout 14.958 9.672 BBAminus -139.88, -164.81 -155.74, 124.37 -98.42, -30.89 272.45, 94.35 80.92, 43.41 in-in in 8.161 Saltbr-in 2.576 HRD-in -62.12, -53.83 87.41, -26.87 in-out-in SNCioi out-in ActLoopNT-out 16.163 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.47, 150.88 APE9-dihe-in -140.18, 135.21 APE8-dihe-in -65.94, 87.96 APE8-rot-na 341.9 APE67-dihe-in -68.13, -18.79 -49.49, -50.03 APE12-dist-na 15.039 APE11-dist-na 10.614 APE10-dist-na 8.582 APE9-dist-in 7.317 None None None XRAY 2.7 0.267 0.314 A 293 269 5 0 0 0 [[242, 495]] 1.0 2hzn Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 6HD6B P00520 229 510 1123.0 STI:60601 Type2 Inactive DFGout 13.829 11.179 BBAminus -125.12, -175.5 -154.19, 103.09 -91.96, 21.1 310.97, 128.7 31.22, 64.2 in-in in 8.394 Saltbr-in 3.072 HRD-in -85.22, -51.46 85.37, -17.4 in-out-in SNCioi out-in ActLoopNT-out 16.369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.94, 122.32 APE9-dihe-in -101.91, 149.19 APE8-dihe-in -81.38, 82.15 APE8-rot-na 19.67 APE67-dihe-in -78.93, -7.66 -49.97, -39.1 APE12-dist-na 15.412 APE11-dist-na 11.178 APE10-dist-na 8.764 APE9-dist-in 7.782 None None None XRAY 2.3 0.178 0.238 B 293 279 3 0 0 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MS9A P00520 230 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.66 10.992 BBAminus -129.69, -177.84 -146.05, 100.92 -85.37, -0.41 305.07, 135.33 63.76, 47.34 in-in in 8.341 Saltbr-in 3.153 HRD-in -79.52, -52.27 83.07, -15.37 in-out-in SNCioi out-in ActLoopNT-out 16.086 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.38, 129.78 APE9-dihe-in -118.07, 145.91 APE8-dihe-in -88.08, 91.81 APE8-rot-na 29.01 APE67-dihe-in -75.19, -6.62 -50.02, -40.18 APE12-dist-na 14.363 APE11-dist-na 12.22 APE10-dist-na 8.639 APE9-dist-in 7.532 None None None XRAY 1.8 0.188 0.234 A 293 261 8 0 0 2 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MS9B P00520 229 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.648 10.944 BBAminus -132.64, -179.46 -143.9, 102.88 -90.37, 5.1 303.67, 135.83 60.73, 51.4 in-in in 8.292 Saltbr-in 2.781 HRD-in -83.7, -52.15 86.58, -11.15 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.02, 135.09 APE9-dihe-in -128.33, 142.16 APE8-dihe-in -86.14, 87.78 APE8-rot-na 36.31 APE67-dihe-in -76.28, -2.93 -48.89, -43.33 APE12-dist-na 15.591 APE11-dist-na 13.452 APE10-dist-na 8.856 APE9-dist-in 7.628 None None None XRAY 1.8 0.188 0.234 B 293 267 3 0 0 0 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSA P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.602 10.927 BBAminus -140.22, -178.36 -147.69, 104.27 -89.71, -2.47 299.0, 139.73 66.29, 43.35 in-in in 8.389 Saltbr-in 3.095 HRD-in -74.19, -56.0 83.94, -13.58 in-out-in SNCioi out-in ActLoopNT-out 16.219 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.21, 134.82 APE9-dihe-in -123.76, 144.56 APE8-dihe-in -89.25, 91.24 APE8-rot-na 26.73 APE67-dihe-in -76.81, -6.98 -52.23, -37.7 APE12-dist-na 14.446 APE11-dist-na 11.974 APE10-dist-na 8.581 APE9-dist-in 7.441 None None None XRAY 1.95 0.172 0.22 A 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSB P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.6 10.82 BBAminus -134.26, 179.26 -142.74, 100.94 -88.95, 3.79 301.55, 135.44 59.27, 50.16 in-in in 8.188 Saltbr-in 2.729 HRD-in -84.32, -52.44 85.34, -18.42 in-out-in SNCioi out-in ActLoopNT-out 15.326 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.6, 137.91 APE9-dihe-in -132.77, 140.13 APE8-dihe-in -80.01, 89.25 APE8-rot-na 23.44 APE67-dihe-in -77.65, -10.14 -50.83, -40.78 APE12-dist-na 15.576 APE11-dist-na 13.486 APE10-dist-na 8.8 APE9-dist-in 7.455 None None None XRAY 1.95 0.172 0.22 B 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSC P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.591 10.963 BBAminus -138.8, 179.7 -144.18, 103.21 -86.54, 1.5 302.89, 134.71 58.1, 46.5 in-in in 8.088 Saltbr-in 3.047 HRD-in -78.89, -57.09 86.43, -17.08 in-out-in SNCioi out-in ActLoopNT-out 16.108 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.32, 131.91 APE9-dihe-in -126.48, 145.59 APE8-dihe-in -89.99, 90.94 APE8-rot-na 26.3 APE67-dihe-in -77.37, -6.31 -51.14, -38.56 APE12-dist-na 14.594 APE11-dist-na 11.85 APE10-dist-na 8.463 APE9-dist-in 7.442 None None None XRAY 1.95 0.172 0.22 C 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3MSSD P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.547 10.788 BBAminus -134.13, -175.99 -148.24, 101.28 -89.17, 5.19 302.32, 137.83 56.24, 49.56 in-in in 8.192 Saltbr-in 2.789 HRD-in -83.98, -55.12 89.03, -15.39 in-out-in SNCioi out-in ActLoopNT-out 15.539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.05, 133.37 APE9-dihe-in -131.92, 141.87 APE8-dihe-in -80.66, 89.72 APE8-rot-na 31.84 APE67-dihe-in -74.69, -8.69 -52.73, -42.14 APE12-dist-na 15.622 APE11-dist-na 13.606 APE10-dist-na 8.783 APE9-dist-in 7.554 None None None XRAY 1.95 0.172 0.22 D 293 260 7 0 0 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1M52A P00520 232 502 1123.0 P17:119 Type1.5_Back Inactive DFGout 12.793 10.753 None -60.22, 138.56 -89.44, -13.76 -71.29, 150.54 62.03, 63.6 85.22, 23.45 in-in in 7.895 Saltbr-in 2.707 HRD-out -103.5, 129.11 -84.41, -9.26 in-out-in SNCioi out-in ActLoopNT-out 5.523 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.32, 126.97 APE9-dihe-in -125.58, 158.53 APE8-dihe-in -60.22, 106.23 APE8-rot-na 28.98 APE67-dihe-in -61.13, -15.48 -48.91, -53.77 APE12-dist-na 18.536 APE11-dist-na 14.052 APE10-dist-na 17.1 APE9-dist-in 6.34 None None None XRAY 2.6 0.211 0.254 A 293 271 0 0 0 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1M52B P00520 232 503 1123.0 P17:120 Type1.5_Back Inactive DFGout 12.781 10.997 None -67.54, 135.07 -84.58, -12.33 -70.24, 151.37 63.17, 66.62 85.76, 18.68 in-in in 8.096 Saltbr-in 2.823 HRD-out -106.35, 123.08 -78.82, -9.36 in-out-in SNCioi out-in ActLoopNT-out 5.579 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.32, 130.43 APE9-dihe-in -127.38, 164.85 APE8-dihe-in -67.06, 104.95 APE8-rot-na 28.73 APE67-dihe-in -58.93, -14.72 -46.9, -55.31 APE12-dist-na 18.942 APE11-dist-na 14.182 APE10-dist-na 17.032 APE9-dist-in 6.37 None None None XRAY 2.6 0.211 0.254 B 293 272 0 0 0 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 1OPKA P00520 64 512 1123.0 P16:60002 Type1.5_Back Inactive DFGout 12.853 11.524 None -65.37, 134.02 -116.02, 33.5 -83.75, 159.92 53.06, 70.43 67.02, 7.91 in-in in 7.957 Saltbr-in 2.94 HRD-in -97.25, -54.03 73.87, -6.88 in-out-in SNCioi out-in ActLoopNT-out 5.558 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.1, 127.8 APE9-dihe-in -117.64, 161.56 APE8-dihe-in -80.21, 93.15 APE8-rot-na 30.65 APE67-dihe-in -63.48, -19.22 -41.98, -48.41 APE12-dist-na 19.48 APE11-dist-na 14.753 APE10-dist-na 17.431 APE9-dist-in 7.125 D363N None None XRAY 1.8 0.196 0.221 A 495 449 0 0 0 0 [[242, 495]] 1.0 1opk Mus musculus TYR_ABL1_MOUSE TYR 5.5e-99 337.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1_MOUSE 3DK7B P00520 233 505 1123.0 SX7:2 Type1 Inactive None 999.0 999.0 None -70.09, 131.91 -99.1, 30.92 -47.67, -78.64 999.0, 999.0 -116.53, 59.69 in-none in 8.153 Saltbr-none 999.0 HRD-in -96.35, -57.33 75.78, -1.22 none-out-in SNCnoi out-in ActLoopNT-out 5.635 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.0, 138.44 APE9-dihe-in -123.96, 150.21 APE8-dihe-in -64.33, 99.33 APE8-rot-na 21.28 APE67-dihe-in -72.95, -10.57 -50.9, -44.43 APE12-dist-na 19.136 APE11-dist-na 14.483 APE10-dist-na 17.474 APE9-dist-in 7.019 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 B 277 269 4 0 0 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1