TYR_ABL1 (Tyrosine-protein kinase ABL1)

Total number of chains: 96
Active chains: 11
Uniprot: ABL1_HUMAN
Kinase Domain Residues: 242 - 495
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 29 30.2% 3QRJB
DFGinter None 26 27.1% 2G2HA
DFGin BLAminus 16 16.7% AF-P00519-K1A
DFGout None 15 15.6% 2HZIA
DFGin BLBplus 6 6.2% 2G1TA
DFGinter BABtrans 3 3.1% 7W7XA
None None 1 1.0% 4WA9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL1 2HZ4C P00519 234 500 1130.0 4ST:501 Allosteric Active DFGin 7.1088 13.5166 BLAminus -106.9, 179.4 68.82, 76.0 -90.83, 7.94 295.39, 93.15 -43.83, -23.1 in-in in 7.8776 Saltbr-in 2.737 HRD-in -90.54, -43.68 68.76, 3.22 in-in-in SNCiii in-in ActLoopNT-in 2.9997 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.98, 153.91 APE9-dihe-in -143.05, 161.74 APE8-dihe-in -62.63, 109.18 APE8-rot-na 10.02 APE67-dihe-in -54.86, -29.12 -56.69, -54.75 APE12-dist-na 14.9509 APE11-dist-na 10.1567 APE10-dist-na 13.1342 APE9-dist-in 7.4103 None None None XRAY 2.8 0.22 0.285 C 273.0 259.0 8 29 29 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7N9GB P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.7541 13.4449 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.8072 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.0408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.9514 APE11-dist-na 10.1213 APE10-dist-na 12.2789 APE9-dist-in 7.1369 None None None XRAY 2.2 0.219 0.251 B 271.0 264.0 2 29 29 0 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 AF-P00519-K1A P00519 234 503 1130.0 No_ligand No_ligand Active DFGin 6.6789 13.6815 BLAminus -121.82, -148.36 27.66, 69.52 -83.21, 16.04 300.66, 100.42 -58.22, -38.59 in-in in 7.9804 Saltbr-in 2.6792 HRD-in -80.76, -46.58 69.6, -13.75 in-in-in SNCiii in-in ActLoopNT-in 2.9836 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.75, 141.7 APE9-dihe-in -129.36, 153.57 APE8-dihe-in -68.2, 94.98 APE8-rot-na 29.24 APE67-dihe-in -68.16, -17.51 -48.71, -43.64 APE12-dist-na 14.7917 APE11-dist-na 9.9692 APE10-dist-na 12.4075 APE9-dist-in 6.9515 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[242, 495]] 1.0 AF-P00519-K1 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 AF-P00519-K3A P00519 234 503 1130.0 No_ligand No_ligand Active DFGin 6.3611 13.5794 BLAminus -138.26, -173.5 60.01, 57.15 -76.49, 13.27 303.75, 99.33 -58.39, -34.06 in-in in 7.8147 Saltbr-in 2.7548 HRD-in -85.57, -49.18 70.08, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.9865 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.76, 136.34 APE9-dihe-in -128.76, 153.96 APE8-dihe-in -76.2, 91.75 APE8-rot-na 33.55 APE67-dihe-in -64.39, -24.25 -44.48, -44.47 APE12-dist-na 14.6351 APE11-dist-na 9.825 APE10-dist-na 11.7284 APE9-dist-in 6.6007 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[242, 495]] 1.0 AF-P00519-K3 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4TWPA P00519 233 503 1130.0 AXI:601 Type1 Active DFGin 6.8259 13.373 BLAminus -126.1, -169.4 57.38, 73.68 -93.34, 9.79 307.92, 111.58 -48.96, -36.81 in-in in 7.9815 Saltbr-in 2.4457 HRD-in -95.85, -58.6 83.7, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.9456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.5, 146.64 APE9-dihe-in -124.84, 163.92 APE8-dihe-in -72.62, 90.26 APE8-rot-na 28.03 APE67-dihe-in -71.19, -17.43 -45.75, -44.99 APE12-dist-na 14.9888 APE11-dist-na 10.1946 APE10-dist-na 13.2123 APE9-dist-in 7.1681 T315I None None XRAY 2.4 0.213 0.241 A 271.0 266.0 5 29 29 0 [[242, 495]] 1.0 4twp TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4TWPB P00519 233 503 1130.0 AXI:601 Type1 Active DFGin 6.7276 13.1173 BLAminus -138.14, -168.47 59.67, 66.52 -88.52, 8.05 307.93, 102.65 -49.29, -39.91 in-in in 7.7725 Saltbr-in 2.6482 HRD-in -82.31, -50.76 78.18, -18.83 in-in-in SNCiii in-in ActLoopNT-in 2.9595 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.57, 120.03 APE9-dihe-in -116.59, 156.81 APE8-dihe-in -66.81, 119.12 APE8-rot-na 347.15 APE67-dihe-in -70.99, -21.45 -67.92, -38.41 APE12-dist-na 15.2079 APE11-dist-na 10.6544 APE10-dist-na 13.0356 APE9-dist-in 6.8475 T315I None None XRAY 2.4 0.213 0.241 B 271.0 271.0 0 29 29 0 [[242, 495]] 1.0 4twp TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2V7AA P00519 233 503 1130.0 627:1504 Type1 Active DFGin 6.8938 14.1604 BLAminus -145.06, -170.76 64.01, 66.73 -92.57, 17.46 295.88, 104.37 -56.64, -27.12 in-in in 7.7819 Saltbr-in 2.5187 HRD-in -93.72, -56.9 83.27, 8.16 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.69, 132.9 APE9-dihe-in -115.95, 155.97 APE8-dihe-in -67.28, 120.19 APE8-rot-na 16.95 APE67-dihe-in -81.75, -3.2 -58.95, -43.12 APE12-dist-na 14.8661 APE11-dist-na 10.2235 APE10-dist-na 13.0157 APE9-dist-in 6.8409 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 A 286.0 271.0 0 29 29 0 [[242, 495]] 1.0 2v7a TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2V7AB P00519 234 503 1130.0 627:1504 Type1 Active DFGin 6.9036 13.9549 BLAminus -120.25, -166.43 59.68, 67.6 -85.2, 11.1 297.73, 106.5 -52.29, -48.72 in-in in 7.5347 Saltbr-in 2.6962 HRD-in -95.53, -42.9 77.78, -18.98 in-in-in SNCiii in-in ActLoopNT-in 3.0418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.95, 149.39 APE9-dihe-in -131.37, 144.36 APE8-dihe-in -64.58, 88.08 APE8-rot-na 22.1 APE67-dihe-in -78.01, -10.87 -49.77, -37.43 APE12-dist-na 14.9545 APE11-dist-na 10.3094 APE10-dist-na 13.1197 APE9-dist-in 7.3589 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 B 286.0 270.0 0 29 29 0 [[242, 495]] 1.0 2v7a TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HZ4B P00519 233 498 1130.0 4ST:501 Type1 Active DFGin 6.7811 12.9056 BLAminus -136.29, 178.03 62.62, 92.29 -99.12, 17.06 306.64, 102.22 -49.71, -38.7 in-in in 8.1144 Saltbr-in 2.713 HRD-in -96.51, -47.12 66.31, -5.28 in-in-in SNCiii in-in ActLoopNT-in 3.1047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.77, 139.94 APE9-dihe-in -124.12, 153.4 APE8-dihe-in -60.98, 117.48 APE8-rot-na 25.18 APE67-dihe-in -77.16, -10.29 -56.55, -40.66 APE12-dist-na 14.7332 APE11-dist-na 10.0035 APE10-dist-na 12.9963 APE9-dist-in 7.1286 None None None XRAY 2.8 0.22 0.285 B 273.0 261.0 5 29 29 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2F4JA P00519 227 513 1130.0 VX6:514 Type1 Active DFGin 6.8309 13.6299 BLAminus -139.09, -163.86 46.92, 83.86 -101.63, 25.32 309.5, 96.14 -54.55, -28.15 in-in in 8.0798 Saltbr-in 2.5828 HRD-in -88.91, -46.94 72.68, 7.25 in-in-in SNCiii in-in ActLoopNT-in 2.8344 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.54, 142.96 APE9-dihe-in -128.46, 161.87 APE8-dihe-in -67.39, 90.98 APE8-rot-na 332.91 APE67-dihe-in -62.36, -25.51 -37.57, -50.75 APE12-dist-na 15.2356 APE11-dist-na 10.4431 APE10-dist-na 13.0857 APE9-dist-in 7.3216 H396P None None XRAY 1.91 0.207 0.239 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 2f4j TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2GQGB P00519 229 499 1130.0 1N1:60502 Type1.5_Back Active DFGin 6.7246 13.4066 BLAminus -132.96, -163.46 57.81, 75.2 -98.78, 6.6 302.62, 104.4 -52.45, -32.74 in-in in 8.0337 Saltbr-in 2.8987 HRD-in -101.91, -48.31 65.85, 10.15 in-in-in SNCiii in-in ActLoopNT-in 2.9585 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.98, 171.69 APE9-dihe-in -137.71, 138.65 APE8-dihe-in -58.61, 114.78 APE8-rot-na 30.65 APE67-dihe-in -71.5, -8.45 -53.53, -44.9 APE12-dist-na 11.2577 APE11-dist-na 7.468 APE10-dist-na 11.6413 APE9-dist-in 6.2756 None PTR393 PTR393 XRAY 2.4 0.208 0.273 B 278.0 271.0 0 29 29 0 [[242, 495]] 1.0 2gqg TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G2IA P00519 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.6309 13.4329 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.0051 Saltbr-in 3.2474 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.0637 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.9044 APE11-dist-na 10.5735 APE10-dist-na 12.836 APE9-dist-in 7.3096 H396P None None XRAY 3.12 0.251 0.308 A 287.0 271.0 3 29 29 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G2IB P00519 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.6234 13.7447 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.7947 Saltbr-in 2.8716 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.4038 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.9753 APE11-dist-na 10.3404 APE10-dist-na 12.8288 APE9-dist-in 7.6248 H396P None None XRAY 3.12 0.251 0.308 B 287.0 265.0 4 29 29 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HZ4A P00519 234 500 1130.0 4ST:501 Allosteric Inactive DFGin 6.8992 13.3144 BLAminus -141.07, -179.05 61.44, 74.68 -93.23, 11.06 298.48, 103.02 -47.37, -45.58 in-out in 8.0434 Saltbr-out 4.199 HRD-in -73.48, -44.6 66.11, 2.51 out-in-in SNCoii in-in ActLoopNT-in 3.1356 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.55, 127.23 APE9-dihe-in -112.0, 154.72 APE8-dihe-in -73.75, 92.13 APE8-rot-na 28.06 APE67-dihe-in -62.73, -9.15 -43.63, -56.72 APE12-dist-na 15.4332 APE11-dist-na 10.6082 APE10-dist-na 12.4721 APE9-dist-in 7.4233 None None None XRAY 2.8 0.22 0.285 A 273.0 262.0 5 29 29 0 [[242, 495]] 1.0 2hz4 TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6XR6A P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGin 6.2017 12.576 BLAminus -139.61, -169.12 45.42, 85.51 -100.09, 27.27 299.51, 89.83 -59.45, -29.58 in-in in 8.3649 Saltbr-in 2.7788 HRD-in -105.48, -39.35 69.66, 6.23 in-out-in SNCioi out-in ActLoopNT-out 3.9551 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.77, 106.46 APE9-dihe-in -100.35, 127.3 APE8-dihe-in -74.27, 111.44 APE8-rot-na 29.98 APE67-dihe-in -67.49, -13.13 -54.87, -37.15 APE12-dist-na 11.902 APE11-dist-na 11.4132 APE10-dist-na 7.6383 APE9-dist-in 4.6529 None None None NMR 999.0 999.0 999.0 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 6xr6 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2GQGA P00519 229 500 1130.0 1N1:60501 Type1 Inactive DFGin 6.6367 14.0391 BLAminus -125.87, -162.48 50.1, 80.24 -101.91, 13.59 304.08, 105.04 -55.58, -28.07 in-in in 8.2064 Saltbr-in 3.3367 HRD-in -94.17, -46.19 69.1, 8.59 in-in-out SNCiio in-out ActLoopNT-in 3.0889 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.45, -178.77 APE9-dihe-in -144.75, 146.99 APE8-dihe-in -51.41, 101.22 APE8-rot-na 30.18 APE67-dihe-in -72.33, -8.18 -47.68, -48.27 APE12-dist-na 13.8069 APE11-dist-na 10.1551 APE10-dist-na 13.162 APE9-dist-in 7.0168 None PTR393 PTR393 XRAY 2.4 0.208 0.273 A 278.0 272.0 0 29 29 0 [[242, 495]] 1.0 2gqg TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8SSNB P00519 64 506 1130.0 AY7:60601,SKI:60602 Allosteric,Type1 Inactive DFGin 4.8072 13.6499 BLBplus -122.3, -177.61 58.55, 39.13 -103.24, 130.77 75.83, 117.96 81.37, 999.0 out-out out 13.6196 Saltbr-out 14.026 HRD-in -82.83, -50.46 68.17, -10.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 11.09 APE8-rot-na 31.53 APE67-dihe-in -79.53, -5.66 -99.34, -42.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 B 448.0 385.0 51 29 11 18 [[242, 495]] 1.0 8ssn TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8SSNA P00519 64 507 1130.0 AY7:60601,SKI:60602 Allosteric,Type1.5_Back Inactive DFGin 5.4293 12.6961 BLBplus -123.62, -174.23 61.42, 33.23 -93.01, 133.21 53.71, 95.25 73.81, 0.97 out-out out 14.0376 Saltbr-out 13.9888 HRD-in -74.8, -57.17 85.55, -3.37 out-out-none SNCoon out-none ActLoopNT-out 10.2636 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.56 APE8-rot-na 17.66 APE67-dihe-in -74.03, -24.85 -108.88, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 A 448.0 419.0 16 29 18 11 [[242, 495]] 1.0 8ssn TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G1TA P00519 232 502 1130.0 No_ligand No_ligand Inactive DFGin 5.4891 13.3586 BLBplus -129.52, 174.85 49.7, 38.76 -72.97, 132.27 38.5, 86.98 68.27, 5.02 out-out out 14.3939 Saltbr-out 14.4469 HRD-in -72.65, -55.09 74.07, -6.35 out-out-out SNCooo out-out ActLoopNT-out 7.3326 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -93.21, 127.41 APE9-dihe-in -142.61, 161.69 APE8-dihe-in -90.21, 73.8 APE8-rot-na 25.96 APE67-dihe-in -72.87, -5.55 -36.53, -50.03 APE12-dist-na 21.6951 APE11-dist-na 17.1266 APE10-dist-na 15.5012 APE9-dist-out 8.5033 None None None XRAY 1.8 0.221 0.244 A 287.0 271.0 0 29 29 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G1TB P00519 230 502 1130.0 No_ligand No_ligand Inactive DFGin 5.6127 13.4611 BLBplus -123.19, 174.0 52.07, 35.11 -71.07, 127.0 40.58, 89.58 70.82, 9.16 out-out out 14.5021 Saltbr-out 14.4083 HRD-in -70.85, -56.38 81.24, -19.54 out-out-out SNCooo out-out ActLoopNT-out 7.337 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.93, 136.77 APE9-dihe-in -145.05, 161.95 APE8-dihe-in -89.74, 74.17 APE8-rot-na 33.06 APE67-dihe-in -70.55, -3.76 -28.93, -56.54 APE12-dist-na 21.3693 APE11-dist-na 16.8667 APE10-dist-na 15.5262 APE9-dist-out 8.2708 None None None XRAY 1.8 0.221 0.244 B 287.0 273.0 0 29 29 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G1TC P00519 232 507 1130.0 No_ligand No_ligand Inactive DFGin 5.3943 13.548 BLBplus -120.72, 170.38 50.85, 37.0 -72.09, 126.35 41.53, 90.26 72.34, 10.44 out-out out 14.6649 Saltbr-out 14.686 HRD-in -71.51, -57.81 80.53, -13.86 out-out-out SNCooo out-out ActLoopNT-out 7.3984 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -104.53, 132.88 APE9-dihe-in -148.89, 164.58 APE8-dihe-in -86.44, 74.64 APE8-rot-na 29.85 APE67-dihe-in -67.97, -5.39 -28.15, -57.51 APE12-dist-na 21.3549 APE11-dist-na 16.8935 APE10-dist-na 15.4689 APE9-dist-out 8.1812 None None None XRAY 1.8 0.221 0.244 C 287.0 276.0 0 29 29 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G1TD P00519 229 502 1130.0 No_ligand No_ligand Inactive DFGin 5.7239 13.4907 BLBplus -127.26, 170.73 53.33, 36.32 -70.41, 128.95 38.1, 89.88 67.15, 13.72 out-out out 14.7586 Saltbr-out 14.4787 HRD-in -69.96, -57.67 85.75, -24.63 out-out-out SNCooo out-out ActLoopNT-out 7.3361 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.18, 134.49 APE9-dihe-in -146.03, 159.07 APE8-dihe-in -86.2, 75.17 APE8-rot-na 27.48 APE67-dihe-in -64.32, -8.55 -32.05, -58.59 APE12-dist-na 20.9384 APE11-dist-na 16.4692 APE10-dist-na 15.4232 APE9-dist-out 8.5207 None None None XRAY 1.8 0.221 0.244 D 287.0 274.0 0 29 29 0 [[242, 495]] 1.0 2g1t TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7W7XA P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.5584 7.7862 BABtrans -66.93, 131.45 -122.59, 21.38 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.6645 Saltbr-out 7.9297 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.8276 APE11-dist-na 15.1289 APE10-dist-na 17.9526 APE9-dist-in 7.3471 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272.0 267.0 2 29 29 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7W7XB P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.8455 8.1882 BABtrans -65.38, 135.53 -123.74, 24.69 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.0361 Saltbr-out 8.3302 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.5621 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.9965 APE10-dist-na 17.1335 APE9-dist-in 6.9919 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272.0 264.0 5 29 29 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.0007 8.0224 BABtrans -71.04, 121.63 -84.68, 7.52 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.6427 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.4222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.5596 APE11-dist-na 13.9233 APE10-dist-na 16.5485 APE9-dist-in 6.4285 None None None XRAY 2.891 0.232 0.259 B 408.0 359.0 9 29 29 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.4212 8.1868 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.8784 Saltbr-out 9.7861 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.5443 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.8503 None None None XRAY 2.2 0.219 0.251 A 271.0 250.0 16 29 16 13 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.7618 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.4392 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.4779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.8914 None None None XRAY 2.2 0.219 0.251 C 271.0 233.0 33 29 24 5 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G2FA P00519 232 506 1130.0 No_ligand No_ligand Inactive DFGinter 9.9036 7.2155 None -62.11, 127.98 -87.38, -14.52 -64.34, -9.9 184.11, 68.76 -103.31, 15.09 in-out in 8.9231 Saltbr-out 8.9696 HRD-out -103.65, 121.34 -60.45, -26.89 out-out-in SNCooi out-in ActLoopNT-out 5.5372 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.48, 145.14 APE9-dihe-in -132.2, 154.35 APE8-dihe-in -76.87, 87.18 APE8-rot-na 28.49 APE67-dihe-in -66.0, -4.27 -34.28, -57.53 APE12-dist-na 21.4063 APE11-dist-na 16.5765 APE10-dist-na 17.8671 APE9-dist-in 7.4309 H396P None None XRAY 2.7 0.234 0.286 A 287.0 275.0 0 29 29 0 [[242, 495]] 1.0 2g2f TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6BL8A P00519 233 502 1130.0 PVB:601 Type1 Inactive DFGinter 8.6377 5.129 None -71.96, 143.85 -136.17, 39.9 -72.13, -37.4 288.6, 104.47 -92.65, 14.81 in-out in 8.634 Saltbr-out 7.1553 HRD-in -90.04, -55.84 74.1, 2.35 out-out-in SNCooi out-in ActLoopNT-out 5.7263 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.55, 128.85 APE9-dihe-in -120.75, 157.5 APE8-dihe-in -76.2, 98.23 APE8-rot-na 22.7 APE67-dihe-in -70.51, -5.85 -42.21, -49.52 APE12-dist-na 19.8415 APE11-dist-na 15.1306 APE10-dist-na 17.4374 APE9-dist-in 7.0878 None None None XRAY 2.5 0.177 0.204 A 272.0 270.0 0 29 29 0 [[242, 495]] 1.0 6bl8 TYR_ABL1_HUMAN TYR 1e-99 339.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6BL8B P00519 233 504 1130.0 PVB:601 Type1 Inactive DFGinter 8.6162 5.2291 None -71.73, 142.55 -134.64, 39.69 -72.51, -38.46 288.36, 104.6 -92.85, 14.3 in-none in 8.4868 Saltbr-none 999.0 HRD-in -91.59, -53.55 75.4, -2.02 none-out-in SNCnoi out-in ActLoopNT-out 5.4212 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.94, 127.06 APE9-dihe-in -119.46, 155.16 APE8-dihe-in -72.29, 100.21 APE8-rot-na 22.45 APE67-dihe-in -69.04, -6.83 -41.1, -50.73 APE12-dist-na 19.2231 APE11-dist-na 14.5041 APE10-dist-na 17.3505 APE9-dist-in 6.8447 None None None XRAY 2.5 0.177 0.204 B 272.0 268.0 4 29 28 1 [[242, 495]] 1.0 6bl8 TYR_ABL1_HUMAN TYR 1e-99 339.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8I7SA P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 9.1336 7.6312 None -67.26, 134.08 -124.25, 38.37 -90.11, -15.51 320.43, 108.35 -104.88, 9.69 in-in in 8.7109 Saltbr-in 2.997 HRD-in -101.62, -50.5 73.92, -2.89 in-out-in SNCioi out-in ActLoopNT-out 5.6426 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.21, 132.08 APE9-dihe-in -105.71, 156.86 APE8-dihe-in -74.32, 88.38 APE8-rot-na 26.42 APE67-dihe-in -74.59, -6.02 -50.76, -44.43 APE12-dist-na 19.8149 APE11-dist-na 15.1302 APE10-dist-na 17.8588 APE9-dist-in 7.5108 None PTR393 PTR393 XRAY 1.946 0.186 0.216 A 272.0 262.0 7 29 29 0 [[242, 495]] 1.0 8i7s TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8I7SB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.7301 7.6723 None -65.46, 135.7 -123.29, 38.43 -94.21, -15.86 318.08, 102.31 -104.7, 7.72 in-out in 8.7389 Saltbr-out 4.579 HRD-in -100.98, -46.35 75.57, -9.9 out-out-in SNCooi out-in ActLoopNT-out 5.3934 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.26, 135.01 APE9-dihe-in -100.5, 152.85 APE8-dihe-in -79.3, 86.45 APE8-rot-na 26.11 APE67-dihe-in -72.94, -9.36 -50.77, -43.49 APE12-dist-na 18.4898 APE11-dist-na 13.8798 APE10-dist-na 16.5698 APE9-dist-in 7.1976 None PTR393 PTR393 XRAY 1.946 0.186 0.216 B 272.0 264.0 5 29 29 0 [[242, 495]] 1.0 8i7s TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8I7ZB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.4667 7.1288 None -66.85, 127.11 -111.9, 44.88 -97.85, -10.98 300.72, 89.67 -118.62, 22.53 in-in in 8.811 Saltbr-in 3.0792 HRD-in -103.27, -34.43 69.06, -16.77 in-out-in SNCioi out-in ActLoopNT-out 5.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.59, 128.54 APE9-dihe-in -113.43, 144.92 APE8-dihe-in -66.08, 92.18 APE8-rot-na 22.51 APE67-dihe-in -69.32, -14.4 -51.28, -44.78 APE12-dist-na 18.5835 APE11-dist-na 13.9516 APE10-dist-na 16.6887 APE9-dist-in 6.9075 None PTR393 PTR393 XRAY 2.255 0.177 0.213 B 272.0 265.0 4 29 29 0 [[242, 495]] 1.0 8i7z TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7W7YA P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.3834 7.452 None -61.0, 140.15 -123.07, 7.15 -97.99, -19.69 299.86, 99.82 -107.54, 26.38 in-out in 7.8322 Saltbr-out 4.3242 HRD-in -95.67, -53.61 79.5, -5.33 out-out-in SNCooi out-in ActLoopNT-out 5.7165 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.53, 135.86 APE9-dihe-in -112.22, 154.02 APE8-dihe-in -72.0, 92.74 APE8-rot-na 26.94 APE67-dihe-in -71.4, -8.88 -51.03, -45.88 APE12-dist-na 19.6423 APE11-dist-na 14.9895 APE10-dist-na 18.0316 APE9-dist-in 7.4527 None PTR393 PTR393 XRAY 2.2 0.176 0.201 A 276.0 269.0 0 29 29 0 [[242, 495]] 1.0 7w7y TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7W7YB P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.7061 7.9388 None -67.02, 132.31 -125.55, 45.99 -104.04, 122.68 325.21, 94.33 94.56, 12.27 in-out in 9.1195 Saltbr-out 4.5262 HRD-in -107.75, -54.39 71.9, 2.12 out-out-in SNCooi out-in ActLoopNT-out 5.4631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.81, 139.55 APE9-dihe-in -122.0, 156.17 APE8-dihe-in -66.34, 94.72 APE8-rot-na 24.45 APE67-dihe-in -67.89, -13.14 -48.19, -46.95 APE12-dist-na 18.655 APE11-dist-na 14.121 APE10-dist-na 17.5125 APE9-dist-in 7.1565 None PTR393 PTR393 XRAY 2.2 0.176 0.201 B 276.0 267.0 2 29 29 0 [[242, 495]] 1.0 7w7y TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8H7FA P00519 232 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.4392 7.3313 None -69.17, 127.91 -123.7, 53.27 -97.59, -18.49 298.04, 92.12 -115.41, 32.43 in-none in 7.9131 Saltbr-none 999.0 HRD-in -98.47, -51.88 73.34, 1.6 none-out-in SNCnoi out-in ActLoopNT-out 5.7735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.81, 130.64 APE9-dihe-in -111.12, 149.71 APE8-dihe-in -68.85, 91.65 APE8-rot-na 24.28 APE67-dihe-in -80.23, -2.27 -54.19, -39.54 APE12-dist-na 19.803 APE11-dist-na 15.1666 APE10-dist-na 17.763 APE9-dist-in 7.4152 None PTR393 PTR393 XRAY 2.45 0.206 0.234 A 277.0 267.0 2 29 29 0 [[242, 495]] 1.0 8h7f TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8H7FB P00519 233 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.6253 7.6286 None -66.82, 132.57 -128.02, 53.13 -102.99, -16.57 308.49, 91.71 -113.57, 28.76 in-none in 8.398 Saltbr-none 999.0 HRD-out -118.2, 104.8 -89.8, 17.52 none-out-in SNCnoi out-in ActLoopNT-out 5.6393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.35, 131.94 APE9-dihe-in -101.32, 145.24 APE8-dihe-in -82.14, 94.32 APE8-rot-na 25.72 APE67-dihe-in -72.86, -15.28 -51.55, -45.38 APE12-dist-na 18.5042 APE11-dist-na 13.782 APE10-dist-na 16.3817 APE9-dist-in 7.3676 None PTR393 PTR393 XRAY 2.45 0.206 0.234 B 277.0 257.0 11 29 29 0 [[242, 495]] 1.0 8h7f TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8H7HA P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.3897 7.6867 None -66.88, 126.67 -122.6, 45.68 -99.68, -4.7 302.75, 91.96 -123.88, 23.24 in-none in 8.0355 Saltbr-none 999.0 HRD-in -99.74, -50.53 75.81, -4.43 none-out-in SNCnoi out-in ActLoopNT-out 5.7036 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.51, 132.84 APE9-dihe-in -111.46, 154.74 APE8-dihe-in -71.0, 89.59 APE8-rot-na 25.0 APE67-dihe-in -73.93, -5.32 -52.54, -45.5 APE12-dist-na 19.7488 APE11-dist-na 15.1821 APE10-dist-na 18.0666 APE9-dist-in 7.4376 None PTR393 PTR393 XRAY 2.278 0.185 0.221 A 277.0 269.0 0 29 29 0 [[242, 495]] 1.0 8h7h TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8H7HB P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.4891 7.8649 None -64.21, 134.18 -129.36, 51.05 -106.57, -14.6 307.18, 95.7 -114.91, 23.11 in-none in 8.7401 Saltbr-none 999.0 HRD-in -105.06, -54.2 71.08, 0.92 none-out-in SNCnoi out-in ActLoopNT-out 5.5932 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.95, 127.69 APE9-dihe-in -114.73, 145.44 APE8-dihe-in -67.21, 95.26 APE8-rot-na 23.35 APE67-dihe-in -67.71, -18.52 -54.95, -42.72 APE12-dist-na 18.6967 APE11-dist-na 13.9374 APE10-dist-na 16.4493 APE9-dist-in 6.6979 None PTR393 PTR393 XRAY 2.278 0.185 0.221 B 277.0 258.0 11 29 29 0 [[242, 495]] 1.0 8h7h TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4ZOGA P00519 233 501 1130.0 VX6:601 Type1 Inactive DFGinter 9.0345 8.1883 None -67.97, 132.1 -127.82, 25.62 -66.74, -66.47 163.98, 49.73 -79.37, 45.35 out-out out 10.9745 Saltbr-out 6.7673 HRD-out -91.32, 151.74 -125.52, 16.46 out-out-in SNCooi out-in ActLoopNT-out 5.5021 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.42, 138.31 APE9-dihe-in -118.45, 160.42 APE8-dihe-in -78.39, 96.94 APE8-rot-na 30.14 APE67-dihe-in -71.46, -10.56 -52.82, -45.85 APE12-dist-na 19.8085 APE11-dist-na 15.163 APE10-dist-na 17.4227 APE9-dist-in 7.1442 None None None XRAY 2.3 0.187 0.233 A 283.0 269.0 0 29 29 0 [[242, 495]] 1.0 4zog TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7CC2A P00519 233 501 1130.0 FVC:601 Type1 Inactive DFGinter 9.165 8.2582 None -73.32, 112.44 -109.3, 64.01 -105.28, -20.44 309.47, 116.75 -109.01, 28.74 out-out out 11.0848 Saltbr-out 8.3686 HRD-in -90.34, -46.17 72.58, 0.36 out-out-in SNCooi out-in ActLoopNT-out 5.6175 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.21, 129.2 APE9-dihe-in -111.79, 156.63 APE8-dihe-in -66.39, 106.43 APE8-rot-na 344.92 APE67-dihe-in -73.87, -6.7 -58.13, -47.58 APE12-dist-na 19.2521 APE11-dist-na 14.4724 APE10-dist-na 17.3207 APE9-dist-in 6.8625 None None None XRAY 2.723 0.196 0.242 A 310.0 263.0 6 29 29 0 [[242, 495]] 1.0 7cc2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7CC2B P00519 232 501 1130.0 FVC:601 Type1 Inactive DFGinter 8.9786 8.607 None -71.77, 114.13 -110.49, 61.26 -109.45, -24.12 312.83, 116.95 -111.64, 29.87 in-none in 9.5409 Saltbr-none 999.0 HRD-in -88.51, -47.46 71.59, 1.41 none-out-in SNCnoi out-in ActLoopNT-out 5.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.35, 131.77 APE9-dihe-in -108.11, 154.53 APE8-dihe-in -67.24, 106.75 APE8-rot-na 21.35 APE67-dihe-in -74.13, -7.58 -57.65, -47.12 APE12-dist-na 19.1078 APE11-dist-na 14.3895 APE10-dist-na 17.5862 APE9-dist-in 7.0083 None None None XRAY 2.723 0.196 0.242 B 310.0 266.0 4 29 29 0 [[242, 495]] 1.0 7cc2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7DT2A P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.472 7.3955 None -67.36, 135.71 -126.94, 46.3 -101.94, -14.95 304.55, 98.79 -112.2, 27.67 in-out in 9.0003 Saltbr-out 3.7981 HRD-in -98.03, -51.7 81.6, -7.87 out-out-in SNCooi out-in ActLoopNT-out 5.7492 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.44, 133.63 APE9-dihe-in -118.19, 150.76 APE8-dihe-in -62.24, 99.73 APE8-rot-na 22.52 APE67-dihe-in -73.29, -7.91 -58.82, -45.37 APE12-dist-na 19.6063 APE11-dist-na 14.9562 APE10-dist-na 17.8178 APE9-dist-in 7.2588 None None None XRAY 2.3 0.208 0.237 A 310.0 265.0 3 29 29 0 [[242, 495]] 1.0 7dt2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 7DT2B P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.633 7.8528 None -67.09, 137.47 -125.9, 46.84 -103.12, -16.04 307.9, 99.91 -112.15, 26.28 in-out in 9.5935 Saltbr-out 4.0836 HRD-in -96.99, -47.74 84.36, -13.26 out-out-in SNCooi out-in ActLoopNT-out 5.563 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.22, 136.31 APE9-dihe-in -118.25, 150.94 APE8-dihe-in -59.92, 103.33 APE8-rot-na 21.91 APE67-dihe-in -72.55, -10.92 -57.38, -43.07 APE12-dist-na 18.6276 APE11-dist-na 13.9652 APE10-dist-na 17.3546 APE9-dist-in 6.6653 None None None XRAY 2.3 0.208 0.237 B 310.0 267.0 1 29 29 0 [[242, 495]] 1.0 7dt2 TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G2HA P00519 233 504 1130.0 P16:60532 Type1 Inactive DFGinter 10.338 7.7628 None -69.8, 139.79 -117.08, 21.66 -74.78, -30.76 182.98, 70.09 -83.63, 27.99 in-out in 8.9475 Saltbr-out 8.4749 HRD-out -106.09, 125.25 -68.95, -15.96 out-out-in SNCooi out-in ActLoopNT-out 5.6222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.55, 116.51 APE9-dihe-in -118.82, 162.2 APE8-dihe-in -67.24, 92.86 APE8-rot-na 32.82 APE67-dihe-in -70.58, -6.79 -39.4, -50.98 APE12-dist-na 19.9464 APE11-dist-na 15.2345 APE10-dist-na 17.2038 APE9-dist-in 6.5344 H396P None None XRAY 2.0 0.194 0.213 A 287.0 272.0 0 29 29 0 [[242, 495]] 1.0 2g2h TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4XEYA P00519 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.9273 None -70.89, 123.51 -90.91, 18.27 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.9479 Saltbr-out 8.6903 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.3933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.7302 APE11-dist-na 14.1077 APE10-dist-na 16.5419 APE9-dist-in 6.5879 None None None XRAY 2.891 0.232 0.259 A 408.0 269.0 4 29 29 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8I7ZA P00519 232 499 1130.0 6CI:601,BAL:602 Type1,Type1 Inactive DFGinter 8.675 7.469 None -68.15, 124.34 -115.26, 44.89 -92.28, -20.89 299.64, 92.88 -113.55, 33.09 in-none in 9.0131 Saltbr-none 999.0 HRD-in -101.45, -51.38 75.46, -1.93 none-out-in SNCnoi out-in ActLoopNT-out 5.7346 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.91, 129.83 APE9-dihe-in -107.25, 158.29 APE8-dihe-in -77.21, 88.15 APE8-rot-na 26.6 APE67-dihe-in -78.48, -3.49 -49.13, -44.82 APE12-dist-na 19.9913 APE11-dist-na 15.3458 APE10-dist-na 18.0738 APE9-dist-in 7.5127 None PTR393 PTR393 XRAY 2.255 0.177 0.213 A 272.0 258.0 10 29 29 0 [[242, 495]] 1.0 8i7z TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4YC8A P00519 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.2536 9.4795 None -68.71, 128.66 -122.3, 46.03 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.1416 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.4398 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.1265 APE11-dist-na 14.4499 APE10-dist-na 17.471 APE9-dist-in 6.7471 None None None XRAY 2.9 0.199 0.24 A 287.0 259.0 10 29 29 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4YC8B P00519 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.5551 9.6924 None -74.12, 129.26 -121.25, 39.81 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.8223 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.4443 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.6692 APE11-dist-na 14.9891 APE10-dist-na 17.7851 APE9-dist-in 6.9304 None None None XRAY 2.9 0.199 0.24 B 287.0 264.0 6 29 29 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 9KS5A P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.7305 5.5961 None -72.67, 142.35 -137.94, 44.53 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.0052 Saltbr-na 6.5449 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.8077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.8189 APE11-dist-na 15.2479 APE10-dist-na 18.1002 APE9-dist-in 7.5449 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272.0 267.0 1 29 29 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 9KS5B P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.9707 5.8466 None -69.26, 149.18 -127.32, 25.05 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.9604 Saltbr-na 6.2903 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.4644 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.4239 APE11-dist-na 14.0576 APE10-dist-na 17.2646 APE9-dist-in 6.8918 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272.0 268.0 0 29 29 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6XRGA P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.0059 8.6965 BBAminus -171.83, 165.33 -155.54, 133.54 -84.4, -28.08 302.76, 128.31 104.78, 35.25 in-in in 8.0626 Saltbr-in 3.1402 HRD-in -67.57, -50.13 76.12, -27.45 in-out-out SNCioo out-out ActLoopNT-out 18.4136 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -124.03, 17.56 APE9-dihe-in -95.78, 148.38 APE8-dihe-in -59.62, 96.75 APE8-rot-na 336.69 APE67-dihe-in -65.49, -36.89 -72.8, -27.02 APE12-dist-na 14.3999 APE11-dist-na 13.4574 APE10-dist-na 9.2109 APE9-dist-in 6.3602 G250E,M290L,T389Y None None NMR 999.0 999.0 999.0 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 6xrg TYR_ABL1_HUMAN TYR 1.3e-100 341.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3QRJA P00519 234 496 1130.0 919:2 Type2 Inactive DFGout 13.1495 8.9896 BBAminus -140.1, 177.46 -140.75, 104.13 -86.94, 4.73 283.88, 85.78 63.32, 48.64 in-in in 7.6735 Saltbr-in 2.7754 HRD-in -79.02, -49.06 80.26, -14.09 in-out-in SNCioi out-in ActLoopNT-out 14.9879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.38, 130.47 APE9-dihe-in -139.16, 150.69 APE8-dihe-in -78.39, 79.63 APE8-rot-na 34.62 APE67-dihe-in -72.48, -9.29 -46.12, -53.19 APE12-dist-na 18.622 APE11-dist-na 15.6447 APE10-dist-na 10.8448 APE9-dist-in 7.3579 T315I None None XRAY 1.82 0.232 0.286 A 277.0 258.0 5 29 29 0 [[242, 495]] 1.0 3qrj TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3QRJB P00519 233 497 1130.0 919:1 Type2 Inactive DFGout 13.1286 9.0788 BBAminus -139.41, 169.11 -133.48, 106.22 -82.14, 0.45 283.14, 89.48 61.09, 48.15 in-in in 7.9313 Saltbr-in 2.7953 HRD-in -78.78, -56.83 82.44, -6.52 in-out-in SNCioi out-in ActLoopNT-out 15.1049 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.29, 121.26 APE9-dihe-in -134.93, 153.91 APE8-dihe-in -77.7, 85.51 APE8-rot-na 33.76 APE67-dihe-in -63.53, -18.09 -55.44, -46.47 APE12-dist-na 18.6564 APE11-dist-na 15.3761 APE10-dist-na 10.8226 APE9-dist-in 7.7219 T315I None None XRAY 1.82 0.232 0.286 B 277.0 265.0 0 29 29 0 [[242, 495]] 1.0 3qrj TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HZ0A P00519 233 497 1130.0 GIN:600 Type2 Inactive DFGout 16.3147 10.4751 BBAminus -150.83, -160.56 -160.34, 120.0 -81.87, -18.31 276.95, 79.02 -92.52, 170.28 in-in in 7.814 Saltbr-in 2.6962 HRD-in -75.66, -51.7 79.36, -13.13 in-out-in SNCioi out-in ActLoopNT-out 6.647 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.12, 134.88 APE9-dihe-in -108.63, 131.61 APE8-dihe-in -62.36, 119.6 APE8-rot-na 29.91 APE67-dihe-in -70.7, -20.49 -52.84, -40.81 APE12-dist-na 12.4615 APE11-dist-na 9.6029 APE10-dist-na 12.5475 APE9-dist-in 6.1546 None None None XRAY 2.1 0.195 0.256 A 270.0 265.0 0 29 29 0 [[242, 495]] 1.0 2hz0 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HZ0B P00519 228 497 1130.0 GIN:600 Type2 Inactive DFGout 16.1446 10.2879 BBAminus -144.12, -165.06 -157.27, 107.1 -67.75, -17.6 276.47, 79.62 51.54, 32.42 in-in in 7.8512 Saltbr-in 2.5019 HRD-in -77.02, -51.65 87.26, -10.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.38 APE8-rot-na 355.54 APE67-dihe-in -66.19, -16.4 -42.69, -41.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.195 0.256 B 270.0 243.0 27 29 12 17 [[242, 495]] 1.0 2hz0 TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HYYA P00519 235 498 1130.0 STI:600 Type2 Inactive DFGout 13.4478 10.9363 BBAminus -136.71, -169.54 -156.86, 107.67 -99.35, 1.46 307.94, 127.18 66.47, 52.08 in-in in 8.2395 Saltbr-in 3.0042 HRD-in -68.42, -63.13 91.16, -9.54 in-out-in SNCioi out-in ActLoopNT-out 16.0994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.4, 131.38 APE9-dihe-in -122.46, 141.0 APE8-dihe-in -82.09, 92.82 APE8-rot-na 22.51 APE67-dihe-in -74.51, -8.92 -44.66, -47.4 APE12-dist-na 14.4582 APE11-dist-na 11.9011 APE10-dist-na 8.4151 APE9-dist-in 7.3935 None None None XRAY 2.4 0.208 0.267 A 273.0 263.0 1 29 29 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HYYB P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6073 10.8376 BBAminus -140.46, -179.87 -145.37, 104.9 -88.0, -4.17 302.17, 134.32 68.19, 47.44 in-in in 8.468 Saltbr-in 2.9739 HRD-in -72.33, -53.74 81.02, -14.85 in-out-in SNCioi out-in ActLoopNT-out 15.7155 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.08, 127.85 APE9-dihe-in -116.06, 145.63 APE8-dihe-in -88.84, 91.14 APE8-rot-na 22.78 APE67-dihe-in -77.2, -5.94 -46.52, -42.21 APE12-dist-na 14.4786 APE11-dist-na 11.9487 APE10-dist-na 8.4213 APE9-dist-in 7.4165 None None None XRAY 2.4 0.208 0.267 B 273.0 265.0 1 29 29 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HYYC P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.817 11.1447 BBAminus -136.58, -170.43 -156.15, 102.72 -91.16, -2.19 306.71, 138.1 61.3, 49.16 in-in in 8.2912 Saltbr-in 3.4095 HRD-in -75.29, -48.77 83.65, -17.42 in-out-in SNCioi out-in ActLoopNT-out 15.6362 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.7, 128.89 APE9-dihe-in -132.69, 141.39 APE8-dihe-in -86.44, 89.34 APE8-rot-na 30.23 APE67-dihe-in -75.71, -10.45 -48.99, -40.28 APE12-dist-na 15.6276 APE11-dist-na 13.5323 APE10-dist-na 8.7762 APE9-dist-in 7.5146 None None None XRAY 2.4 0.208 0.267 C 273.0 262.0 4 29 26 3 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HYYD P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6269 11.0079 BBAminus -135.11, -170.82 -155.12, 109.43 -96.64, 9.5 309.68, 132.23 60.03, 43.1 in-in in 8.0089 Saltbr-in 2.7581 HRD-in -69.95, -55.57 86.15, -21.95 in-out-in SNCioi out-in ActLoopNT-out 15.3354 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 121.23 APE9-dihe-in -126.0, 140.68 APE8-dihe-in -79.93, 90.29 APE8-rot-na 35.26 APE67-dihe-in -80.44, -14.01 -57.15, -31.16 APE12-dist-na 15.6748 APE11-dist-na 13.4748 APE10-dist-na 8.574 APE9-dist-in 7.5548 None None None XRAY 2.4 0.208 0.267 D 273.0 264.0 2 29 29 0 [[242, 495]] 1.0 2hyy TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3CS9A P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.5926 11.1183 BBAminus -145.37, -175.21 -153.52, 95.68 -79.44, 2.63 308.67, 139.53 60.14, 48.09 in-in in 7.9872 Saltbr-in 2.9586 HRD-in -72.5, -52.05 83.05, -14.51 in-out-in SNCioi out-in ActLoopNT-out 15.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.13, 125.61 APE9-dihe-in -114.38, 144.88 APE8-dihe-in -83.08, 84.52 APE8-rot-na 33.34 APE67-dihe-in -71.16, -7.94 -52.7, -43.38 APE12-dist-na 15.6378 APE11-dist-na 11.341 APE10-dist-na 8.5859 APE9-dist-in 7.762 None None None XRAY 2.21 0.2 0.242 A 277.0 264.0 4 29 29 0 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3CS9B P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.4559 10.7526 BBAminus -144.0, -176.67 -148.15, 110.4 -103.8, 0.8 309.16, 135.76 150.34, 999.0 in-in in 8.2215 Saltbr-in 3.4798 HRD-in -70.96, -54.76 81.36, -12.94 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.55 APE8-rot-na 31.92 APE67-dihe-in -70.26, -17.41 -42.99, -45.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 B 277.0 247.0 21 29 11 18 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3CS9C P00519 232 497 1130.0 NIL:600 Type2 Inactive DFGout 13.7124 10.9182 BBAminus -141.39, 177.78 -141.43, 100.61 -84.1, -4.94 304.15, 138.08 61.69, 999.0 in-in in 7.9551 Saltbr-in 2.8283 HRD-in -74.87, -48.82 81.89, -13.85 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.51 APE8-rot-na 36.98 APE67-dihe-in -69.35, -10.43 -43.96, -42.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 C 277.0 243.0 23 29 11 18 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3CS9D P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.7784 11.7574 BBAminus -137.25, -170.7 -151.81, 104.77 -89.11, 0.3 306.25, 137.53 63.13, 44.73 in-in in 7.8883 Saltbr-in 2.7404 HRD-in -68.82, -44.23 79.28, -14.07 in-out-in SNCioi out-in ActLoopNT-out 15.5902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.05, 117.02 APE9-dihe-in -109.67, 147.03 APE8-dihe-in -87.1, 85.65 APE8-rot-na 29.26 APE67-dihe-in -63.61, -19.67 -51.69, -46.78 APE12-dist-na 16.1499 APE11-dist-na 12.1503 APE10-dist-na 8.7581 APE9-dist-in 7.5814 None None None XRAY 2.21 0.2 0.242 D 277.0 263.0 5 29 29 0 [[242, 495]] 1.0 3cs9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3QRIA P00519 229 498 1130.0 919:60500 Type2 Inactive DFGout 13.4048 9.244 BBAminus -140.23, -177.67 -143.73, 111.06 -85.62, -1.21 285.71, 95.83 64.84, 45.13 in-in in 7.938 Saltbr-in 2.6713 HRD-in -68.59, -54.98 84.86, -16.08 in-out-in SNCioi out-in ActLoopNT-out 15.3297 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.68, 128.64 APE9-dihe-in -141.86, 154.54 APE8-dihe-in -79.64, 85.81 APE8-rot-na 26.51 APE67-dihe-in -72.47, -7.02 -44.71, -48.72 APE12-dist-na 18.4987 APE11-dist-na 15.5857 APE10-dist-na 10.7258 APE9-dist-in 7.4255 None None None XRAY 2.1 0.216 0.272 A 277.0 270.0 0 29 29 0 [[242, 495]] 1.0 3qri TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3QRIB P00519 232 498 1130.0 919:60002 Type2 Inactive DFGout 13.3944 9.3548 BBAminus -137.99, -177.06 -143.59, 113.56 -88.43, -2.03 287.13, 98.7 64.72, 47.42 in-in in 7.8509 Saltbr-in 2.8565 HRD-in -75.25, -51.53 85.01, -17.97 in-out-in SNCioi out-in ActLoopNT-out 15.3271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.54, 128.19 APE9-dihe-in -140.43, 156.29 APE8-dihe-in -80.95, 78.25 APE8-rot-na 29.21 APE67-dihe-in -73.74, -7.02 -42.67, -45.53 APE12-dist-na 18.487 APE11-dist-na 15.5621 APE10-dist-na 10.7895 APE9-dist-in 7.4803 None None None XRAY 2.1 0.216 0.272 B 277.0 262.0 5 29 29 0 [[242, 495]] 1.0 3qri TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HIWA P00519 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.3473 10.8265 BBAminus -142.71, -168.33 -158.01, 107.74 -97.35, 2.37 312.36, 126.58 65.32, 50.81 in-out in 8.2289 Saltbr-out 3.7404 HRD-in -73.86, -48.39 84.66, -24.64 out-out-in SNCooi out-in ActLoopNT-out 15.6369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 130.36 APE9-dihe-in -115.68, 135.96 APE8-dihe-in -85.15, 68.17 APE8-rot-na 24.2 APE67-dihe-in -72.17, -12.42 -32.25, -48.66 APE12-dist-na 13.5733 APE11-dist-na 12.4749 APE10-dist-na 8.1904 APE9-dist-in 7.7237 None None None XRAY 2.2 0.246 0.309 A 287.0 270.0 0 29 29 0 [[242, 495]] 1.0 2hiw TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HIWB P00519 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.0877 11.2071 BBAminus -144.46, -168.71 -161.12, 102.71 -97.39, 4.98 318.67, 117.06 56.31, 54.08 in-in in 8.0153 Saltbr-in 2.7868 HRD-in -67.44, -50.02 79.19, -15.91 in-out-in SNCioi out-in ActLoopNT-out 15.9652 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.79, 117.59 APE9-dihe-in -110.67, 133.98 APE8-dihe-in -80.14, 91.72 APE8-rot-na 27.82 APE67-dihe-in -76.13, -9.39 -64.08, -40.93 APE12-dist-na 14.6952 APE11-dist-na 12.5191 APE10-dist-na 8.4947 APE9-dist-in 7.6721 None None None XRAY 2.2 0.246 0.309 B 287.0 270.0 0 29 29 0 [[242, 495]] 1.0 2hiw TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2E2BA P00519 229 502 1130.0 406:61001 Type2 Inactive DFGout 13.6369 10.9141 BBAminus -135.1, -171.45 -153.85, 101.44 -92.52, 5.9 308.25, 136.28 52.63, 55.21 in-in in 8.4387 Saltbr-in 2.958 HRD-in -72.49, -53.7 81.83, -19.66 in-out-in SNCioi out-in ActLoopNT-out 15.4827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.77, 121.49 APE9-dihe-in -121.85, 146.58 APE8-dihe-in -80.67, 88.23 APE8-rot-na 34.75 APE67-dihe-in -71.79, -9.02 -46.22, -43.83 APE12-dist-na 15.609 APE11-dist-na 11.3547 APE10-dist-na 8.5173 APE9-dist-in 7.2711 None None None XRAY 2.2 0.236 0.27 A 293.0 266.0 8 29 25 4 [[242, 495]] 1.0 2e2b TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2E2BB P00519 229 497 1130.0 406:61002 Type2 Inactive DFGout 13.647 10.9332 BBAminus -143.5, -176.35 -149.87, 101.4 -87.9, 0.31 305.42, 141.47 55.35, 49.49 in-in in 8.4517 Saltbr-in 2.8516 HRD-in -72.44, -52.01 77.65, -14.12 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.83, 116.83 APE9-dihe-in -124.88, 142.96 APE8-dihe-in -78.59, 83.23 APE8-rot-na 29.89 APE67-dihe-in -65.0, -9.5 -42.19, -50.29 APE12-dist-na 15.6557 APE11-dist-na 11.8314 APE10-dist-na 8.4692 APE9-dist-in 7.2202 None None None XRAY 2.2 0.236 0.27 B 293.0 258.0 11 29 23 6 [[242, 495]] 1.0 2e2b TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 5HU9A P00519 229 499 1130.0 66K:60601,66K:60602 Type2,Allosteric Inactive DFGout 15.803 10.497 BBAminus -145.4, -177.31 -141.71, 111.16 -69.31, -26.01 283.1, 65.03 93.44, 13.86 in-in in 8.0827 Saltbr-in 2.7689 HRD-in -68.36, -51.36 83.46, -11.3 in-out-out SNCioo out-out ActLoopNT-out 13.3135 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -72.36, -42.02 APE9-dihe-in -132.05, 79.59 APE8-dihe-in -81.54, 66.0 APE8-rot-na 26.81 APE67-dihe-in -69.94, -12.93 -59.43, -37.79 APE12-dist-na 9.5095 APE11-dist-na 5.4553 APE10-dist-na 6.0943 APE9-dist-out 9.516 None None None XRAY 1.529 0.186 0.196 A 277.0 266.0 5 29 24 5 [[242, 495]] 1.0 5hu9 TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3PYYA P00519 232 500 1130.0 STI:60003,3YY:60538 Type2,Allosteric Inactive DFGout 13.6472 11.2623 BBAminus -130.42, -173.45 -148.82, 100.51 -87.29, -2.92 301.78, 132.98 62.26, 50.77 in-in in 8.1427 Saltbr-in 2.677 HRD-in -77.84, -60.13 91.69, -13.02 in-out-in SNCioi out-in ActLoopNT-out 15.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.57, 117.7 APE9-dihe-in -121.79, 141.76 APE8-dihe-in -85.05, 87.91 APE8-rot-na 30.64 APE67-dihe-in -73.12, -6.21 -47.76, -45.73 APE12-dist-na 16.5248 APE11-dist-na 12.81 APE10-dist-na 8.6957 APE9-dist-in 7.7291 None None None XRAY 1.85 0.189 0.204 A 298.0 265.0 4 29 29 0 [[242, 495]] 1.0 3pyy TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3PYYB P00519 233 510 1130.0 STI:60004,3YY:60532 Type2,Allosteric Inactive DFGout 13.9702 11.0172 BBAminus -132.59, -172.42 -152.94, 105.37 -94.38, -50.82 313.04, 135.61 93.2, 999.0 in-in in 8.1 Saltbr-in 2.5706 HRD-in -81.0, -57.03 86.3, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -127.99, 138.02 APE9-dihe-in -152.66, 146.9 APE8-dihe-in -80.16, 79.64 APE8-rot-na 29.64 APE67-dihe-in -75.32, -11.37 -49.83, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.258 None None None XRAY 1.85 0.189 0.204 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 3pyy TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6NPEA P00519 232 500 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.751 11.2768 BBAminus -132.09, -171.87 -150.82, 100.43 -86.72, -1.03 301.5, 131.9 61.32, 51.13 in-in in 8.1711 Saltbr-in 2.7788 HRD-in -75.05, -56.53 78.97, -9.5 in-out-in SNCioi out-in ActLoopNT-out 15.7357 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.77, 121.63 APE9-dihe-in -123.35, 140.69 APE8-dihe-in -84.02, 84.76 APE8-rot-na 23.95 APE67-dihe-in -76.42, -6.93 -49.4, -44.5 APE12-dist-na 16.5922 APE11-dist-na 12.7878 APE10-dist-na 8.7525 APE9-dist-in 7.8443 None None None XRAY 2.15 0.187 0.212 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npe TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6NPEB P00519 233 511 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.8401 11.1015 BBAminus -129.89, -169.38 -152.66, 105.04 -92.73, -27.9 303.95, 134.44 82.3, 999.0 in-in in 8.2217 Saltbr-in 2.6842 HRD-in -80.48, -54.98 79.49, -7.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.9 APE8-dihe-in -75.88, 86.79 APE8-rot-na 23.52 APE67-dihe-in -70.62, -18.32 -51.39, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6859 None None None XRAY 2.15 0.187 0.212 B 298.0 256.0 23 29 12 17 [[242, 495]] 1.0 6npe TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6NPUA P00519 232 500 1130.0 STI:60601,KWV:60602 Type2,Allosteric Inactive DFGout 13.7239 11.3407 BBAminus -131.32, -177.82 -147.63, 103.5 -91.61, -2.68 302.6, 133.1 64.49, 56.03 in-in in 8.1753 Saltbr-in 2.6429 HRD-in -76.28, -58.38 85.82, -8.07 in-out-in SNCioi out-in ActLoopNT-out 15.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 129.98 APE9-dihe-in -123.79, 139.52 APE8-dihe-in -78.9, 90.13 APE8-rot-na 28.21 APE67-dihe-in -75.75, -3.63 -52.56, -44.81 APE12-dist-na 16.3124 APE11-dist-na 12.5979 APE10-dist-na 8.715 APE9-dist-in 7.8012 None None None XRAY 2.33 0.196 0.234 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npu TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6NPUB P00519 233 510 1130.0 STI:60602,KWV:60605 Type2,Allosteric Inactive DFGout 13.7158 11.1215 BBAminus -136.03, -173.76 -148.73, 104.54 -94.68, -39.85 309.09, 136.14 93.88, 999.0 in-in in 8.0462 Saltbr-in 2.6551 HRD-in -88.42, -57.18 82.99, -10.02 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.51, 88.48 APE9-dihe-in -97.46, 155.87 APE8-dihe-in -87.38, 82.63 APE8-rot-na 29.77 APE67-dihe-in -64.85, -22.06 -45.68, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8546 None None None XRAY 2.33 0.196 0.234 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npu TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6NPVA P00519 232 500 1130.0 STI:60602,KWP:60603 Type2,Allosteric Inactive DFGout 13.575 11.2109 BBAminus -133.43, -176.32 -147.26, 102.27 -88.44, -2.86 301.02, 133.29 64.03, 50.03 in-in in 8.1581 Saltbr-in 2.9685 HRD-in -74.61, -59.03 88.55, -10.34 in-out-in SNCioi out-in ActLoopNT-out 15.7382 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.7, 120.65 APE9-dihe-in -115.73, 140.1 APE8-dihe-in -81.63, 87.3 APE8-rot-na 30.14 APE67-dihe-in -75.75, -5.01 -52.83, -44.97 APE12-dist-na 16.3027 APE11-dist-na 12.2839 APE10-dist-na 8.7127 APE9-dist-in 7.7824 None None None XRAY 1.86 0.183 0.207 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npv TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6NPVB P00519 233 510 1130.0 STI:60603,KWP:60607 Type2,Allosteric Inactive DFGout 13.5449 11.0623 BBAminus -135.7, -168.07 -155.88, 101.76 -93.13, -7.53 306.52, 136.97 78.01, 999.0 in-in in 8.2003 Saltbr-in 2.7509 HRD-in -76.84, -57.95 84.26, -8.39 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.75, 102.42 APE9-dihe-in -114.18, 151.63 APE8-dihe-in -86.78, 85.36 APE8-rot-na 20.0 APE67-dihe-in -75.22, -6.58 -51.86, -43.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9656 None None None XRAY 1.86 0.183 0.207 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npv TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3QRKA P00519 229 496 1130.0 9DP:60001 Type3 Inactive DFGout 13.5376 9.2632 BBAminus -128.74, -174.73 -147.03, 106.14 -83.7, 8.0 281.11, 96.68 56.22, 46.71 in-in in 7.8529 Saltbr-in 2.6737 HRD-in -77.83, -51.71 87.8, -21.18 in-out-in SNCioi out-in ActLoopNT-out 15.3027 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.14, 132.07 APE9-dihe-in -145.7, 147.79 APE8-dihe-in -79.52, 88.76 APE8-rot-na 26.7 APE67-dihe-in -65.94, -15.53 -54.88, -43.49 APE12-dist-na 18.8146 APE11-dist-na 15.7582 APE10-dist-na 10.9913 APE9-dist-in 7.5852 None None None XRAY 2.3 0.192 0.281 A 277.0 268.0 0 29 29 0 [[242, 495]] 1.0 3qrk TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G2FB P00519 234 502 1130.0 AGS:601 ATPlike Inactive DFGout 13.4774 11.5253 None -73.05, 151.22 -78.4, -31.56 -2.81, -74.15 167.03, 54.1 -90.78, 24.63 in-in in 8.8964 Saltbr-in 3.3728 HRD-out -112.09, 115.32 -73.34, -1.05 in-out-in SNCioi out-in ActLoopNT-out 5.759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.67, 144.36 APE9-dihe-in -134.57, 156.36 APE8-dihe-in -59.22, 104.92 APE8-rot-na 31.18 APE67-dihe-in -59.35, -15.8 -52.01, -51.94 APE12-dist-na 18.8868 APE11-dist-na 14.2996 APE10-dist-na 17.6873 APE9-dist-in 6.8177 H396P None None XRAY 2.7 0.234 0.286 B 287.0 264.0 5 29 29 0 [[242, 495]] 1.0 2g2f TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 6XR7A P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.4425 8.628 None -113.31, -174.74 -119.02, 30.04 -65.72, 104.77 191.29, 77.0 102.04, -118.08 in-in in 7.642 Saltbr-in 2.805 HRD-in -104.45, -51.55 70.39, 1.66 in-out-out SNCioo out-out ActLoopNT-out 4.9623 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 60.98, -93.15 APE9-dihe-out 55.27, 119.08 APE8-dihe-in -62.33, 109.76 APE8-rot-na 22.3 APE67-dihe-in -67.97, -13.01 -57.05, -38.83 APE12-dist-na 12.2575 APE11-dist-na 9.5131 APE10-dist-na 11.2076 APE9-dist-in 7.7064 None None None NMR 999.0 999.0 999.0 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 6xr7 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8I7TB P00519 232 500 1130.0 6I5:601 Type1 Inactive DFGout 13.4131 11.662 None -78.21, 133.76 -76.1, -34.26 58.37, -123.75 266.71, 82.63 -125.63, 98.01 in-in in 9.5758 Saltbr-in 3.2593 HRD-in -106.12, -52.02 70.25, 2.56 in-out-in SNCioi out-in ActLoopNT-out 5.657 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.56, 141.45 APE9-dihe-in -118.71, 149.22 APE8-dihe-in -71.44, 98.5 APE8-rot-na 25.12 APE67-dihe-in -70.33, -18.58 -57.67, -41.4 APE12-dist-na 18.1415 APE11-dist-na 13.5979 APE10-dist-na 16.9845 APE9-dist-in 6.8506 None PTR393 PTR393 XRAY 2.8 0.221 0.272 B 272.0 263.0 6 29 29 0 [[242, 495]] 1.0 8i7t TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HZIA P00519 233 500 1130.0 JIN:600 Type1 Inactive DFGout 12.6724 11.025 None -64.65, 136.57 -117.47, 21.9 -67.4, 155.9 48.8, 72.68 74.75, 2.18 in-in in 8.0101 Saltbr-in 2.7508 HRD-in -100.41, -50.8 74.37, -4.5 in-out-in SNCioi out-in ActLoopNT-out 5.6021 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.67, 131.39 APE9-dihe-in -115.42, 162.87 APE8-dihe-in -80.35, 88.85 APE8-rot-na 20.47 APE67-dihe-in -70.91, -11.25 -48.9, -44.37 APE12-dist-na 19.4441 APE11-dist-na 14.8564 APE10-dist-na 17.6914 APE9-dist-in 7.1792 None None None XRAY 1.7 0.177 0.204 A 277.0 268.0 0 29 29 0 [[242, 495]] 1.0 2hzi TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4ZOGB P00519 234 503 1130.0 VX6:601 Type1 Inactive DFGout 11.7889 11.8279 None -72.45, 126.77 -115.82, 44.9 -59.71, -111.34 30.08, 49.18 -63.43, 48.35 in-in in 8.8801 Saltbr-in 3.108 HRD-in -92.87, -52.54 77.42, -2.86 in-out-in SNCioi out-in ActLoopNT-out 5.5005 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.26, 120.92 APE9-dihe-in -100.0, 141.29 APE8-dihe-in -74.27, 97.66 APE8-rot-na 25.54 APE67-dihe-in -72.2, -10.54 -59.59, -40.07 APE12-dist-na 17.8557 APE11-dist-na 13.8579 APE10-dist-na 16.2066 APE9-dist-in 6.9896 None None None XRAY 2.3 0.187 0.233 B 283.0 268.0 2 29 27 2 [[242, 495]] 1.0 4zog TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4WA9B P00519 246 508 1130.0 AXI:69000 Type1 Inactive DFGout 13.3112 10.2815 None -75.93, 149.51 -77.88, -15.66 -59.19, 118.14 191.81, 69.86 106.96, -1.52 in-in in 7.643 Saltbr-in 2.0564 HRD-out -116.7, 121.02 -81.78, -7.12 in-out-in SNCioi out-in ActLoopNT-out 5.3274 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.35, 121.29 APE9-dihe-in -115.41, 155.9 APE8-dihe-in -66.84, 110.63 APE8-rot-na 32.52 APE67-dihe-in -70.78, -12.55 -43.03, -46.3 APE12-dist-na 18.4998 APE11-dist-na 13.938 APE10-dist-na 17.4982 APE9-dist-in 6.7106 None None None XRAY 2.2 0.175 0.212 B 286.0 263.0 0 29 29 0 [[242, 495]] 1.0 4wa9 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3UE4A P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.4713 10.0872 None -73.57, 139.68 -129.47, 18.74 -70.04, -27.22 71.97, 85.11 -97.86, 45.9 in-out in 8.1219 Saltbr-out 4.0052 HRD-out -105.15, 128.48 -83.8, -2.91 out-out-in SNCooi out-in ActLoopNT-out 5.2939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 137.39 APE9-dihe-in -119.63, 157.7 APE8-dihe-in -69.93, 97.57 APE8-rot-na 25.4 APE67-dihe-in -65.99, -15.91 -45.97, -49.68 APE12-dist-na 19.2109 APE11-dist-na 14.4694 APE10-dist-na 17.1224 APE9-dist-in 6.8357 None None None XRAY 2.424 0.192 0.249 A 287.0 270.0 0 29 29 0 [[242, 495]] 1.0 3ue4 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 3UE4B P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.2239 10.4796 None -68.43, 143.68 -139.88, 24.33 -73.48, -36.67 65.16, 97.6 -93.69, 7.14 in-out in 8.4914 Saltbr-out 3.7707 HRD-in -88.28, -56.6 76.68, -0.41 out-out-in SNCooi out-in ActLoopNT-out 5.4413 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.79, 122.21 APE9-dihe-in -108.43, 151.01 APE8-dihe-in -71.16, 105.45 APE8-rot-na 24.97 APE67-dihe-in -72.18, -12.67 -59.58, -44.17 APE12-dist-na 19.4531 APE11-dist-na 14.7482 APE10-dist-na 17.2117 APE9-dist-in 6.8924 None None None XRAY 2.424 0.192 0.249 B 287.0 268.0 2 29 29 0 [[242, 495]] 1.0 3ue4 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 8I7TA P00519 232 500 1130.0 6I5:601 Type1.5_Back Inactive DFGout 13.2636 11.9557 None -62.98, 128.57 -72.85, -7.53 36.94, -135.32 264.95, 6.34 101.46, 15.06 in-in in 8.5956 Saltbr-in 3.2755 HRD-in -96.98, -47.23 68.77, 7.6 in-out-in SNCioi out-in ActLoopNT-out 5.8528 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.95, 130.91 APE9-dihe-in -108.03, 159.47 APE8-dihe-in -73.45, 92.08 APE8-rot-na 23.57 APE67-dihe-in -76.01, -8.31 -52.5, -40.25 APE12-dist-na 19.7336 APE11-dist-na 15.1378 APE10-dist-na 18.0684 APE9-dist-in 7.3114 None PTR393 PTR393 XRAY 2.8 0.221 0.272 A 272.0 267.0 2 29 29 0 [[242, 495]] 1.0 8i7t TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2HZIB P00519 233 500 1130.0 JIN:600 Type1.5_Back Inactive DFGout 12.6514 10.8001 None -64.82, 139.58 -123.5, 22.46 -72.33, 154.15 44.58, 70.92 81.45, -10.45 in-in in 8.0484 Saltbr-in 2.7877 HRD-in -103.52, -56.2 76.53, -2.92 in-out-in SNCioi out-in ActLoopNT-out 5.5339 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.65, 133.63 APE9-dihe-in -122.59, 157.35 APE8-dihe-in -72.25, 93.6 APE8-rot-na 22.08 APE67-dihe-in -66.73, -17.62 -46.65, -45.74 APE12-dist-na 19.118 APE11-dist-na 14.4068 APE10-dist-na 17.1847 APE9-dist-in 6.7955 None None None XRAY 1.7 0.177 0.204 B 277.0 264.0 4 29 29 0 [[242, 495]] 1.0 2hzi TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2G2HB P00519 233 504 1130.0 P16:60532 Type1.5_Back Inactive DFGout 12.6989 10.5001 None -60.13, 139.26 -82.96, -16.55 -75.2, 165.15 55.98, 67.58 79.14, 12.62 in-out in 8.1928 Saltbr-out 6.8591 HRD-out -104.81, 126.85 -89.37, -5.07 out-out-in SNCooi out-in ActLoopNT-out 5.4813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.1, 135.12 APE9-dihe-in -121.36, 158.85 APE8-dihe-in -60.74, 105.18 APE8-rot-na 332.86 APE67-dihe-in -67.82, -12.38 -45.03, -49.81 APE12-dist-na 18.6686 APE11-dist-na 13.9016 APE10-dist-na 17.2439 APE9-dist-in 6.55 H396P None None XRAY 2.0 0.194 0.213 B 287.0 272.0 0 29 29 0 [[242, 495]] 1.0 2g2h TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 2FO0A P00519 46 511 1130.0 P16:60702 Type1.5_Back Inactive DFGout 13.4469 11.7849 None -76.52, 118.23 -95.45, 43.06 -89.94, 155.29 62.25, 72.76 62.2, 26.15 in-in in 8.0548 Saltbr-in 3.1541 HRD-in -101.49, -60.91 80.44, -3.96 in-out-in SNCioi out-in ActLoopNT-out 5.7625 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.77, 155.96 APE9-dihe-in -130.48, 150.83 APE8-dihe-in -76.1, 87.73 APE8-rot-na 30.01 APE67-dihe-in -55.48, -20.39 -31.31, -58.23 APE12-dist-na 19.757 APE11-dist-na 15.0519 APE10-dist-na 18.0531 APE9-dist-in 7.2256 D363N SEP50 SEP50 XRAY 2.27 0.21 0.246 A 495.0 466.0 0 29 29 0 [[242, 495]] 1.0 2fo0 TYR_ABL1_HUMAN TYR 5.5e-99 337.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 1OPLA P00519 62 512 1130.0 P16:60539 Type1.5_Back Inactive DFGout 12.8079 11.6702 None -65.59, 134.14 -116.03, 33.28 -83.5, 159.91 53.21, 70.33 67.06, 8.01 in-in in 7.9532 Saltbr-in 2.9441 HRD-in -97.12, -53.99 73.72, -6.86 in-out-in SNCioi out-in ActLoopNT-out 5.5535 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.98, 127.83 APE9-dihe-in -117.56, 161.51 APE8-dihe-in -80.15, 93.03 APE8-rot-na 30.65 APE67-dihe-in -63.53, -19.0 -41.82, -48.43 APE12-dist-na 19.4826 APE11-dist-na 14.757 APE10-dist-na 17.4347 APE9-dist-in 7.1249 K12R,D363N None None XRAY 3.42 0.306 0.315 A 537.0 451.0 0 29 29 0 [[242, 495]] 1.0 1opl TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 1OPLB P00519 121 499 1130.0 P16:60538 Type1.5_Back Inactive DFGout 12.1961 11.5899 None -63.84, 141.4 -115.91, 33.22 -83.51, 160.0 53.06, 70.48 67.02, 7.94 in-in in 7.991 Saltbr-in 2.943 HRD-in -97.28, -53.9 73.81, -6.95 in-out-in SNCioi out-in ActLoopNT-out 5.553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.01, 127.73 APE9-dihe-in -117.46, 161.57 APE8-dihe-in -80.14, 92.99 APE8-rot-na 30.73 APE67-dihe-in -63.44, -19.12 -41.75, -48.48 APE12-dist-na 19.4824 APE11-dist-na 14.7574 APE10-dist-na 17.4356 APE9-dist-in 7.1251 K12R,D363N None None XRAY 3.42 0.306 0.315 B 537.0 365.0 0 29 29 0 [[242, 495]] 1.0 1opl TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 5MO4A P00519 64 512 1130.0 NIL:60601,AY7:60602 Type2,Allosteric Inactive DFGout 13.9474 11.3183 None -138.43, -177.76 -149.4, 98.71 -92.55, 999.0 320.75, 134.82 999.0, 999.0 in-in in 8.1062 Saltbr-in 2.797 HRD-in -66.66, -50.58 73.57, -12.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -49.47 APE8-dihe-out -61.4, -6.43 APE8-rot-na 335.89 APE67-dihe-in -62.17, -20.21 -56.07, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.0984 None None None XRAY 2.17 0.184 0.217 A 495.0 429.0 20 29 11 18 [[242, 495]] 1.0 5mo4 TYR_ABL1_HUMAN TYR 1.1e-98 336.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 4WA9A P00519 246 504 1130.0 AXI:69000 Type1 Inactive None 999.0 10.3553 None -73.83, 149.34 -77.87, -21.14 -66.14, 121.84 190.75, 64.67 115.23, -11.12 none-none none 999.0 Saltbr-none 999.0 HRD-out -124.23, 124.72 -84.31, -3.72 none-out-in SNCnoi out-in ActLoopNT-out 5.4093 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.89, 135.91 APE9-dihe-in -108.88, 156.35 APE8-dihe-in -71.91, 93.83 APE8-rot-na 24.22 APE67-dihe-in -74.38, -8.52 -49.97, -43.55 APE12-dist-na 18.5615 APE11-dist-na 13.7767 APE10-dist-na 16.6613 APE9-dist-in 6.4914 None None None XRAY 2.2 0.175 0.212 A 286.0 236.0 23 29 29 0 [[242, 495]] 1.0 4wa9 TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

TYR_ABL1 (Tyrosine-protein kinase ABL1)

Total number of chains: 136
Active chains: 16
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 55 40.4% 3KFAA
DFGinter None 31 22.8% 2G2HA
DFGin BLAminus 21 15.4% AF-P00519-K1A
DFGout None 18 13.2% 2HZIA
DFGin BLBplus 6 4.4% 2G1TA
DFGinter BABtrans 3 2.2% 7W7XA
None None 2 1.5% 3DK7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL1 ABL1_HUMAN 2HZ4C P00519 234 500 1130.0 4ST:501 Allosteric Active DFGin 7.1088 13.5166 BLAminus -106.9, 179.4 68.82, 76.0 -90.83, 7.94 295.39, 93.15 -43.83, -23.1 in-in in 7.8776 Saltbr-in 2.737 HRD-in -90.54, -43.68 68.76, 3.22 in-in-in SNCiii in-in ActLoopNT-in 2.9997 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.98, 153.91 APE9-dihe-in -143.05, 161.74 APE8-dihe-in -62.63, 109.18 APE8-rot-na 10.02 APE67-dihe-in -54.86, -29.12 -56.69, -54.75 APE12-dist-na 14.9509 APE11-dist-na 10.1567 APE10-dist-na 13.1342 APE9-dist-in 7.4103 None None None XRAY 2.8 0.22 0.285 C 273.0 259.0 8 29 29 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7N9GB P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Active DFGin 6.7541 13.4449 BLAminus -122.97, -168.58 58.54, 84.79 -109.7, 15.38 305.77, 104.92 -56.72, -36.19 in-in in 7.8072 Saltbr-in 2.716 HRD-in -94.83, -54.73 76.06, 6.03 in-in-in SNCiii in-in ActLoopNT-in 3.0408 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.97, 124.86 APE9-dihe-in -118.42, 152.72 APE8-dihe-in -70.17, 95.62 APE8-rot-na 28.18 APE67-dihe-in -73.36, -13.19 -53.92, -45.07 APE12-dist-na 14.9514 APE11-dist-na 10.1213 APE10-dist-na 12.2789 APE9-dist-in 7.1369 None None None XRAY 2.2 0.219 0.251 B 271.0 264.0 2 29 29 0 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN AF-P00519-K1A P00519 234 503 1130.0 No_ligand No_ligand Active DFGin 6.6789 13.6815 BLAminus -121.82, -148.36 27.66, 69.52 -83.21, 16.04 300.66, 100.42 -58.22, -38.59 in-in in 7.9804 Saltbr-in 2.6792 HRD-in -80.76, -46.58 69.6, -13.75 in-in-in SNCiii in-in ActLoopNT-in 2.9836 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.75, 141.7 APE9-dihe-in -129.36, 153.57 APE8-dihe-in -68.2, 94.98 APE8-rot-na 29.24 APE67-dihe-in -68.16, -17.51 -48.71, -43.64 APE12-dist-na 14.7917 APE11-dist-na 9.9692 APE10-dist-na 12.4075 APE9-dist-in 6.9515 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[242, 495]] 1.0 AF-P00519-K1 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN AF-P00519-K3A P00519 234 503 1130.0 No_ligand No_ligand Active DFGin 6.3611 13.5794 BLAminus -138.26, -173.5 60.01, 57.15 -76.49, 13.27 303.75, 99.33 -58.39, -34.06 in-in in 7.8147 Saltbr-in 2.7548 HRD-in -85.57, -49.18 70.08, -6.29 in-in-in SNCiii in-in ActLoopNT-in 2.9865 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.76, 136.34 APE9-dihe-in -128.76, 153.96 APE8-dihe-in -76.2, 91.75 APE8-rot-na 33.55 APE67-dihe-in -64.39, -24.25 -44.48, -44.47 APE12-dist-na 14.6351 APE11-dist-na 9.825 APE10-dist-na 11.7284 APE9-dist-in 6.6007 None None None AF2 -1.0 1.0 1.0 A 270.0 270.0 0 29 29 0 [[242, 495]] 1.0 AF-P00519-K3 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4TWPA P00519 233 503 1130.0 AXI:601 Type1 Active DFGin 6.8259 13.373 BLAminus -126.1, -169.4 57.38, 73.68 -93.34, 9.79 307.92, 111.58 -48.96, -36.81 in-in in 7.9815 Saltbr-in 2.4457 HRD-in -95.85, -58.6 83.7, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.9456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.5, 146.64 APE9-dihe-in -124.84, 163.92 APE8-dihe-in -72.62, 90.26 APE8-rot-na 28.03 APE67-dihe-in -71.19, -17.43 -45.75, -44.99 APE12-dist-na 14.9888 APE11-dist-na 10.1946 APE10-dist-na 13.2123 APE9-dist-in 7.1681 T315I None None XRAY 2.4 0.213 0.241 A 271.0 266.0 5 29 29 0 [[242, 495]] 1.0 4twp Homo sapiens TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4TWPB P00519 233 503 1130.0 AXI:601 Type1 Active DFGin 6.7276 13.1173 BLAminus -138.14, -168.47 59.67, 66.52 -88.52, 8.05 307.93, 102.65 -49.29, -39.91 in-in in 7.7725 Saltbr-in 2.6482 HRD-in -82.31, -50.76 78.18, -18.83 in-in-in SNCiii in-in ActLoopNT-in 2.9595 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -126.57, 120.03 APE9-dihe-in -116.59, 156.81 APE8-dihe-in -66.81, 119.12 APE8-rot-na 347.15 APE67-dihe-in -70.99, -21.45 -67.92, -38.41 APE12-dist-na 15.2079 APE11-dist-na 10.6544 APE10-dist-na 13.0356 APE9-dist-in 6.8475 T315I None None XRAY 2.4 0.213 0.241 B 271.0 271.0 0 29 29 0 [[242, 495]] 1.0 4twp Homo sapiens TYR_ABL1_HUMAN TYR 4.4e-100 340.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2V7AA P00519 233 503 1130.0 627:1504 Type1 Active DFGin 6.8938 14.1604 BLAminus -145.06, -170.76 64.01, 66.73 -92.57, 17.46 295.88, 104.37 -56.64, -27.12 in-in in 7.7819 Saltbr-in 2.5187 HRD-in -93.72, -56.9 83.27, 8.16 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.69, 132.9 APE9-dihe-in -115.95, 155.97 APE8-dihe-in -67.28, 120.19 APE8-rot-na 16.95 APE67-dihe-in -81.75, -3.2 -58.95, -43.12 APE12-dist-na 14.8661 APE11-dist-na 10.2235 APE10-dist-na 13.0157 APE9-dist-in 6.8409 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 A 286.0 271.0 0 29 29 0 [[242, 495]] 1.0 2v7a Homo sapiens TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2V7AB P00519 234 503 1130.0 627:1504 Type1 Active DFGin 6.9036 13.9549 BLAminus -120.25, -166.43 59.68, 67.6 -85.2, 11.1 297.73, 106.5 -52.29, -48.72 in-in in 7.5347 Saltbr-in 2.6962 HRD-in -95.53, -42.9 77.78, -18.98 in-in-in SNCiii in-in ActLoopNT-in 3.0418 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.95, 149.39 APE9-dihe-in -131.37, 144.36 APE8-dihe-in -64.58, 88.08 APE8-rot-na 22.1 APE67-dihe-in -78.01, -10.87 -49.77, -37.43 APE12-dist-na 14.9545 APE11-dist-na 10.3094 APE10-dist-na 13.1197 APE9-dist-in 7.3589 T315I PTR393 PTR393 XRAY 2.5 0.209 0.246 B 286.0 270.0 0 29 29 0 [[242, 495]] 1.0 2v7a Homo sapiens TYR_ABL1_HUMAN TYR 5.3e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HZ4B P00519 233 498 1130.0 4ST:501 Type1 Active DFGin 6.7811 12.9056 BLAminus -136.29, 178.03 62.62, 92.29 -99.12, 17.06 306.64, 102.22 -49.71, -38.7 in-in in 8.1144 Saltbr-in 2.713 HRD-in -96.51, -47.12 66.31, -5.28 in-in-in SNCiii in-in ActLoopNT-in 3.1047 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -93.77, 139.94 APE9-dihe-in -124.12, 153.4 APE8-dihe-in -60.98, 117.48 APE8-rot-na 25.18 APE67-dihe-in -77.16, -10.29 -56.55, -40.66 APE12-dist-na 14.7332 APE11-dist-na 10.0035 APE10-dist-na 12.9963 APE9-dist-in 7.1286 None None None XRAY 2.8 0.22 0.285 B 273.0 261.0 5 29 29 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2F4JA P00519 227 513 1130.0 VX6:514 Type1 Active DFGin 6.8309 13.6299 BLAminus -139.09, -163.86 46.92, 83.86 -101.63, 25.32 309.5, 96.14 -54.55, -28.15 in-in in 8.0798 Saltbr-in 2.5828 HRD-in -88.91, -46.94 72.68, 7.25 in-in-in SNCiii in-in ActLoopNT-in 2.8344 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.54, 142.96 APE9-dihe-in -128.46, 161.87 APE8-dihe-in -67.39, 90.98 APE8-rot-na 332.91 APE67-dihe-in -62.36, -25.51 -37.57, -50.75 APE12-dist-na 15.2356 APE11-dist-na 10.4431 APE10-dist-na 13.0857 APE9-dist-in 7.3216 H396P None None XRAY 1.91 0.207 0.239 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 2f4j Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2GQGB P00519 229 499 1130.0 1N1:60502 Type1.5_Back Active DFGin 6.7246 13.4066 BLAminus -132.96, -163.46 57.81, 75.2 -98.78, 6.6 302.62, 104.4 -52.45, -32.74 in-in in 8.0337 Saltbr-in 2.8987 HRD-in -101.91, -48.31 65.85, 10.15 in-in-in SNCiii in-in ActLoopNT-in 2.9585 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -100.98, 171.69 APE9-dihe-in -137.71, 138.65 APE8-dihe-in -58.61, 114.78 APE8-rot-na 30.65 APE67-dihe-in -71.5, -8.45 -53.53, -44.9 APE12-dist-na 11.2577 APE11-dist-na 7.468 APE10-dist-na 11.6413 APE9-dist-in 6.2756 None PTR393 PTR393 XRAY 2.4 0.208 0.273 B 278.0 271.0 0 29 29 0 [[242, 495]] 1.0 2gqg Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G2IA P00519 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.6309 13.4329 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.0051 Saltbr-in 3.2474 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.0637 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.9044 APE11-dist-na 10.5735 APE10-dist-na 12.836 APE9-dist-in 7.3096 H396P None None XRAY 3.12 0.251 0.308 A 287.0 271.0 3 29 29 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G2IB P00519 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.6234 13.7447 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.7947 Saltbr-in 2.8716 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.4038 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.9753 APE11-dist-na 10.3404 APE10-dist-na 12.8288 APE9-dist-in 7.6248 H396P None None XRAY 3.12 0.251 0.308 B 287.0 265.0 4 29 29 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HZ4A P00519 234 500 1130.0 4ST:501 Allosteric Inactive DFGin 6.8992 13.3144 BLAminus -141.07, -179.05 61.44, 74.68 -93.23, 11.06 298.48, 103.02 -47.37, -45.58 in-out in 8.0434 Saltbr-out 4.199 HRD-in -73.48, -44.6 66.11, 2.51 out-in-in SNCoii in-in ActLoopNT-in 3.1356 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.55, 127.23 APE9-dihe-in -112.0, 154.72 APE8-dihe-in -73.75, 92.13 APE8-rot-na 28.06 APE67-dihe-in -62.73, -9.15 -43.63, -56.72 APE12-dist-na 15.4332 APE11-dist-na 10.6082 APE10-dist-na 12.4721 APE9-dist-in 7.4233 None None None XRAY 2.8 0.22 0.285 A 273.0 262.0 5 29 29 0 [[242, 495]] 1.0 2hz4 Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6XR6A P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGin 6.2017 12.576 BLAminus -139.61, -169.12 45.42, 85.51 -100.09, 27.27 299.51, 89.83 -59.45, -29.58 in-in in 8.3649 Saltbr-in 2.7788 HRD-in -105.48, -39.35 69.66, 6.23 in-out-in SNCioi out-in ActLoopNT-out 3.9551 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.77, 106.46 APE9-dihe-in -100.35, 127.3 APE8-dihe-in -74.27, 111.44 APE8-rot-na 29.98 APE67-dihe-in -67.49, -13.13 -54.87, -37.15 APE12-dist-na 11.902 APE11-dist-na 11.4132 APE10-dist-na 7.6383 APE9-dist-in 4.6529 None None None NMR 999.0 999.0 999.0 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 6xr6 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2GQGA P00519 229 500 1130.0 1N1:60501 Type1 Inactive DFGin 6.6367 14.0391 BLAminus -125.87, -162.48 50.1, 80.24 -101.91, 13.59 304.08, 105.04 -55.58, -28.07 in-in in 8.2064 Saltbr-in 3.3367 HRD-in -94.17, -46.19 69.1, 8.59 in-in-out SNCiio in-out ActLoopNT-in 3.0889 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -108.45, -178.77 APE9-dihe-in -144.75, 146.99 APE8-dihe-in -51.41, 101.22 APE8-rot-na 30.18 APE67-dihe-in -72.33, -8.18 -47.68, -48.27 APE12-dist-na 13.8069 APE11-dist-na 10.1551 APE10-dist-na 13.162 APE9-dist-in 7.0168 None PTR393 PTR393 XRAY 2.4 0.208 0.273 A 278.0 272.0 0 29 29 0 [[242, 495]] 1.0 2gqg Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8SSNB P00519 64 506 1130.0 AY7:60601,SKI:60602 Allosteric,Type1 Inactive DFGin 4.8072 13.6499 BLBplus -122.3, -177.61 58.55, 39.13 -103.24, 130.77 75.83, 117.96 81.37, 999.0 out-out out 13.6196 Saltbr-out 14.026 HRD-in -82.83, -50.46 68.17, -10.38 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 11.09 APE8-rot-na 31.53 APE67-dihe-in -79.53, -5.66 -99.34, -42.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 B 448.0 385.0 51 29 11 18 [[242, 495]] 1.0 8ssn Homo sapiens TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8SSNA P00519 64 507 1130.0 AY7:60601,SKI:60602 Allosteric,Type1.5_Back Inactive DFGin 5.4293 12.6961 BLBplus -123.62, -174.23 61.42, 33.23 -93.01, 133.21 53.71, 95.25 73.81, 0.97 out-out out 14.0376 Saltbr-out 13.9888 HRD-in -74.8, -57.17 85.55, -3.37 out-out-none SNCoon out-none ActLoopNT-out 10.2636 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 36.56 APE8-rot-na 17.66 APE67-dihe-in -74.03, -24.85 -108.88, -37.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.86 0.3 0.348 A 448.0 419.0 16 29 18 11 [[242, 495]] 1.0 8ssn Homo sapiens TYR_ABL1_HUMAN TYR 1.1e-99 339.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G1TA P00519 232 502 1130.0 No_ligand No_ligand Inactive DFGin 5.4891 13.3586 BLBplus -129.52, 174.85 49.7, 38.76 -72.97, 132.27 38.5, 86.98 68.27, 5.02 out-out out 14.3939 Saltbr-out 14.4469 HRD-in -72.65, -55.09 74.07, -6.35 out-out-out SNCooo out-out ActLoopNT-out 7.3326 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -93.21, 127.41 APE9-dihe-in -142.61, 161.69 APE8-dihe-in -90.21, 73.8 APE8-rot-na 25.96 APE67-dihe-in -72.87, -5.55 -36.53, -50.03 APE12-dist-na 21.6951 APE11-dist-na 17.1266 APE10-dist-na 15.5012 APE9-dist-out 8.5033 None None None XRAY 1.8 0.221 0.244 A 287.0 271.0 0 29 29 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G1TB P00519 230 502 1130.0 No_ligand No_ligand Inactive DFGin 5.6127 13.4611 BLBplus -123.19, 174.0 52.07, 35.11 -71.07, 127.0 40.58, 89.58 70.82, 9.16 out-out out 14.5021 Saltbr-out 14.4083 HRD-in -70.85, -56.38 81.24, -19.54 out-out-out SNCooo out-out ActLoopNT-out 7.337 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.93, 136.77 APE9-dihe-in -145.05, 161.95 APE8-dihe-in -89.74, 74.17 APE8-rot-na 33.06 APE67-dihe-in -70.55, -3.76 -28.93, -56.54 APE12-dist-na 21.3693 APE11-dist-na 16.8667 APE10-dist-na 15.5262 APE9-dist-out 8.2708 None None None XRAY 1.8 0.221 0.244 B 287.0 273.0 0 29 29 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G1TC P00519 232 507 1130.0 No_ligand No_ligand Inactive DFGin 5.3943 13.548 BLBplus -120.72, 170.38 50.85, 37.0 -72.09, 126.35 41.53, 90.26 72.34, 10.44 out-out out 14.6649 Saltbr-out 14.686 HRD-in -71.51, -57.81 80.53, -13.86 out-out-out SNCooo out-out ActLoopNT-out 7.3984 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -104.53, 132.88 APE9-dihe-in -148.89, 164.58 APE8-dihe-in -86.44, 74.64 APE8-rot-na 29.85 APE67-dihe-in -67.97, -5.39 -28.15, -57.51 APE12-dist-na 21.3549 APE11-dist-na 16.8935 APE10-dist-na 15.4689 APE9-dist-out 8.1812 None None None XRAY 1.8 0.221 0.244 C 287.0 276.0 0 29 29 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G1TD P00519 229 502 1130.0 No_ligand No_ligand Inactive DFGin 5.7239 13.4907 BLBplus -127.26, 170.73 53.33, 36.32 -70.41, 128.95 38.1, 89.88 67.15, 13.72 out-out out 14.7586 Saltbr-out 14.4787 HRD-in -69.96, -57.67 85.75, -24.63 out-out-out SNCooo out-out ActLoopNT-out 7.3361 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -95.18, 134.49 APE9-dihe-in -146.03, 159.07 APE8-dihe-in -86.2, 75.17 APE8-rot-na 27.48 APE67-dihe-in -64.32, -8.55 -32.05, -58.59 APE12-dist-na 20.9384 APE11-dist-na 16.4692 APE10-dist-na 15.4232 APE9-dist-out 8.5207 None None None XRAY 1.8 0.221 0.244 D 287.0 274.0 0 29 29 0 [[242, 495]] 1.0 2g1t Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7W7XA P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.5584 7.7862 BABtrans -66.93, 131.45 -122.59, 21.38 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.6645 Saltbr-out 7.9297 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.8276 APE11-dist-na 15.1289 APE10-dist-na 17.9526 APE9-dist-in 7.3471 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272.0 267.0 2 29 29 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7W7XB P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.8455 8.1882 BABtrans -65.38, 135.53 -123.74, 24.69 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.0361 Saltbr-out 8.3302 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.5621 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.9965 APE10-dist-na 17.1335 APE9-dist-in 6.9919 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272.0 264.0 5 29 29 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.0007 8.0224 BABtrans -71.04, 121.63 -84.68, 7.52 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.6427 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.4222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.5596 APE11-dist-na 13.9233 APE10-dist-na 16.5485 APE9-dist-in 6.4285 None None None XRAY 2.891 0.232 0.259 B 408.0 359.0 9 29 29 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.4212 8.1868 None -69.43, 136.44 -123.08, 27.78 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.8784 Saltbr-out 9.7861 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.5443 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.8503 None None None XRAY 2.2 0.219 0.251 A 271.0 250.0 16 29 16 13 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.7618 None -68.53, 140.81 -120.26, 3.31 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.4392 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.4779 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.8914 None None None XRAY 2.2 0.219 0.251 C 271.0 233.0 33 29 24 5 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G2FA P00519 232 506 1130.0 No_ligand No_ligand Inactive DFGinter 9.9036 7.2155 None -62.11, 127.98 -87.38, -14.52 -64.34, -9.9 184.11, 68.76 -103.31, 15.09 in-out in 8.9231 Saltbr-out 8.9696 HRD-out -103.65, 121.34 -60.45, -26.89 out-out-in SNCooi out-in ActLoopNT-out 5.5372 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.48, 145.14 APE9-dihe-in -132.2, 154.35 APE8-dihe-in -76.87, 87.18 APE8-rot-na 28.49 APE67-dihe-in -66.0, -4.27 -34.28, -57.53 APE12-dist-na 21.4063 APE11-dist-na 16.5765 APE10-dist-na 17.8671 APE9-dist-in 7.4309 H396P None None XRAY 2.7 0.234 0.286 A 287.0 275.0 0 29 29 0 [[242, 495]] 1.0 2g2f Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6BL8A P00519 233 502 1130.0 PVB:601 Type1 Inactive DFGinter 8.6377 5.129 None -71.96, 143.85 -136.17, 39.9 -72.13, -37.4 288.6, 104.47 -92.65, 14.81 in-out in 8.634 Saltbr-out 7.1553 HRD-in -90.04, -55.84 74.1, 2.35 out-out-in SNCooi out-in ActLoopNT-out 5.7263 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.55, 128.85 APE9-dihe-in -120.75, 157.5 APE8-dihe-in -76.2, 98.23 APE8-rot-na 22.7 APE67-dihe-in -70.51, -5.85 -42.21, -49.52 APE12-dist-na 19.8415 APE11-dist-na 15.1306 APE10-dist-na 17.4374 APE9-dist-in 7.0878 None None None XRAY 2.5 0.177 0.204 A 272.0 270.0 0 29 29 0 [[242, 495]] 1.0 6bl8 Homo sapiens TYR_ABL1_HUMAN TYR 1e-99 339.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6BL8B P00519 233 504 1130.0 PVB:601 Type1 Inactive DFGinter 8.6162 5.2291 None -71.73, 142.55 -134.64, 39.69 -72.51, -38.46 288.36, 104.6 -92.85, 14.3 in-none in 8.4868 Saltbr-none 999.0 HRD-in -91.59, -53.55 75.4, -2.02 none-out-in SNCnoi out-in ActLoopNT-out 5.4212 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.94, 127.06 APE9-dihe-in -119.46, 155.16 APE8-dihe-in -72.29, 100.21 APE8-rot-na 22.45 APE67-dihe-in -69.04, -6.83 -41.1, -50.73 APE12-dist-na 19.2231 APE11-dist-na 14.5041 APE10-dist-na 17.3505 APE9-dist-in 6.8447 None None None XRAY 2.5 0.177 0.204 B 272.0 268.0 4 29 28 1 [[242, 495]] 1.0 6bl8 Homo sapiens TYR_ABL1_HUMAN TYR 1e-99 339.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8I7SA P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 9.1336 7.6312 None -67.26, 134.08 -124.25, 38.37 -90.11, -15.51 320.43, 108.35 -104.88, 9.69 in-in in 8.7109 Saltbr-in 2.997 HRD-in -101.62, -50.5 73.92, -2.89 in-out-in SNCioi out-in ActLoopNT-out 5.6426 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.21, 132.08 APE9-dihe-in -105.71, 156.86 APE8-dihe-in -74.32, 88.38 APE8-rot-na 26.42 APE67-dihe-in -74.59, -6.02 -50.76, -44.43 APE12-dist-na 19.8149 APE11-dist-na 15.1302 APE10-dist-na 17.8588 APE9-dist-in 7.5108 None PTR393 PTR393 XRAY 1.946 0.186 0.216 A 272.0 262.0 7 29 29 0 [[242, 495]] 1.0 8i7s Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8I7SB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.7301 7.6723 None -65.46, 135.7 -123.29, 38.43 -94.21, -15.86 318.08, 102.31 -104.7, 7.72 in-out in 8.7389 Saltbr-out 4.579 HRD-in -100.98, -46.35 75.57, -9.9 out-out-in SNCooi out-in ActLoopNT-out 5.3934 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -103.26, 135.01 APE9-dihe-in -100.5, 152.85 APE8-dihe-in -79.3, 86.45 APE8-rot-na 26.11 APE67-dihe-in -72.94, -9.36 -50.77, -43.49 APE12-dist-na 18.4898 APE11-dist-na 13.8798 APE10-dist-na 16.5698 APE9-dist-in 7.1976 None PTR393 PTR393 XRAY 1.946 0.186 0.216 B 272.0 264.0 5 29 29 0 [[242, 495]] 1.0 8i7s Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8I7ZB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.4667 7.1288 None -66.85, 127.11 -111.9, 44.88 -97.85, -10.98 300.72, 89.67 -118.62, 22.53 in-in in 8.811 Saltbr-in 3.0792 HRD-in -103.27, -34.43 69.06, -16.77 in-out-in SNCioi out-in ActLoopNT-out 5.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.59, 128.54 APE9-dihe-in -113.43, 144.92 APE8-dihe-in -66.08, 92.18 APE8-rot-na 22.51 APE67-dihe-in -69.32, -14.4 -51.28, -44.78 APE12-dist-na 18.5835 APE11-dist-na 13.9516 APE10-dist-na 16.6887 APE9-dist-in 6.9075 None PTR393 PTR393 XRAY 2.255 0.177 0.213 B 272.0 265.0 4 29 29 0 [[242, 495]] 1.0 8i7z Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7W7YA P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.3834 7.452 None -61.0, 140.15 -123.07, 7.15 -97.99, -19.69 299.86, 99.82 -107.54, 26.38 in-out in 7.8322 Saltbr-out 4.3242 HRD-in -95.67, -53.61 79.5, -5.33 out-out-in SNCooi out-in ActLoopNT-out 5.7165 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.53, 135.86 APE9-dihe-in -112.22, 154.02 APE8-dihe-in -72.0, 92.74 APE8-rot-na 26.94 APE67-dihe-in -71.4, -8.88 -51.03, -45.88 APE12-dist-na 19.6423 APE11-dist-na 14.9895 APE10-dist-na 18.0316 APE9-dist-in 7.4527 None PTR393 PTR393 XRAY 2.2 0.176 0.201 A 276.0 269.0 0 29 29 0 [[242, 495]] 1.0 7w7y Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7W7YB P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.7061 7.9388 None -67.02, 132.31 -125.55, 45.99 -104.04, 122.68 325.21, 94.33 94.56, 12.27 in-out in 9.1195 Saltbr-out 4.5262 HRD-in -107.75, -54.39 71.9, 2.12 out-out-in SNCooi out-in ActLoopNT-out 5.4631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.81, 139.55 APE9-dihe-in -122.0, 156.17 APE8-dihe-in -66.34, 94.72 APE8-rot-na 24.45 APE67-dihe-in -67.89, -13.14 -48.19, -46.95 APE12-dist-na 18.655 APE11-dist-na 14.121 APE10-dist-na 17.5125 APE9-dist-in 7.1565 None PTR393 PTR393 XRAY 2.2 0.176 0.201 B 276.0 267.0 2 29 29 0 [[242, 495]] 1.0 7w7y Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8H7FA P00519 232 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.4392 7.3313 None -69.17, 127.91 -123.7, 53.27 -97.59, -18.49 298.04, 92.12 -115.41, 32.43 in-none in 7.9131 Saltbr-none 999.0 HRD-in -98.47, -51.88 73.34, 1.6 none-out-in SNCnoi out-in ActLoopNT-out 5.7735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.81, 130.64 APE9-dihe-in -111.12, 149.71 APE8-dihe-in -68.85, 91.65 APE8-rot-na 24.28 APE67-dihe-in -80.23, -2.27 -54.19, -39.54 APE12-dist-na 19.803 APE11-dist-na 15.1666 APE10-dist-na 17.763 APE9-dist-in 7.4152 None PTR393 PTR393 XRAY 2.45 0.206 0.234 A 277.0 267.0 2 29 29 0 [[242, 495]] 1.0 8h7f Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8H7FB P00519 233 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.6253 7.6286 None -66.82, 132.57 -128.02, 53.13 -102.99, -16.57 308.49, 91.71 -113.57, 28.76 in-none in 8.398 Saltbr-none 999.0 HRD-out -118.2, 104.8 -89.8, 17.52 none-out-in SNCnoi out-in ActLoopNT-out 5.6393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -85.35, 131.94 APE9-dihe-in -101.32, 145.24 APE8-dihe-in -82.14, 94.32 APE8-rot-na 25.72 APE67-dihe-in -72.86, -15.28 -51.55, -45.38 APE12-dist-na 18.5042 APE11-dist-na 13.782 APE10-dist-na 16.3817 APE9-dist-in 7.3676 None PTR393 PTR393 XRAY 2.45 0.206 0.234 B 277.0 257.0 11 29 29 0 [[242, 495]] 1.0 8h7f Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8H7HA P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.3897 7.6867 None -66.88, 126.67 -122.6, 45.68 -99.68, -4.7 302.75, 91.96 -123.88, 23.24 in-none in 8.0355 Saltbr-none 999.0 HRD-in -99.74, -50.53 75.81, -4.43 none-out-in SNCnoi out-in ActLoopNT-out 5.7036 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.51, 132.84 APE9-dihe-in -111.46, 154.74 APE8-dihe-in -71.0, 89.59 APE8-rot-na 25.0 APE67-dihe-in -73.93, -5.32 -52.54, -45.5 APE12-dist-na 19.7488 APE11-dist-na 15.1821 APE10-dist-na 18.0666 APE9-dist-in 7.4376 None PTR393 PTR393 XRAY 2.278 0.185 0.221 A 277.0 269.0 0 29 29 0 [[242, 495]] 1.0 8h7h Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8H7HB P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.4891 7.8649 None -64.21, 134.18 -129.36, 51.05 -106.57, -14.6 307.18, 95.7 -114.91, 23.11 in-none in 8.7401 Saltbr-none 999.0 HRD-in -105.06, -54.2 71.08, 0.92 none-out-in SNCnoi out-in ActLoopNT-out 5.5932 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.95, 127.69 APE9-dihe-in -114.73, 145.44 APE8-dihe-in -67.21, 95.26 APE8-rot-na 23.35 APE67-dihe-in -67.71, -18.52 -54.95, -42.72 APE12-dist-na 18.6967 APE11-dist-na 13.9374 APE10-dist-na 16.4493 APE9-dist-in 6.6979 None PTR393 PTR393 XRAY 2.278 0.185 0.221 B 277.0 258.0 11 29 29 0 [[242, 495]] 1.0 8h7h Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4ZOGA P00519 233 501 1130.0 VX6:601 Type1 Inactive DFGinter 9.0345 8.1883 None -67.97, 132.1 -127.82, 25.62 -66.74, -66.47 163.98, 49.73 -79.37, 45.35 out-out out 10.9745 Saltbr-out 6.7673 HRD-out -91.32, 151.74 -125.52, 16.46 out-out-in SNCooi out-in ActLoopNT-out 5.5021 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.42, 138.31 APE9-dihe-in -118.45, 160.42 APE8-dihe-in -78.39, 96.94 APE8-rot-na 30.14 APE67-dihe-in -71.46, -10.56 -52.82, -45.85 APE12-dist-na 19.8085 APE11-dist-na 15.163 APE10-dist-na 17.4227 APE9-dist-in 7.1442 None None None XRAY 2.3 0.187 0.233 A 283.0 269.0 0 29 29 0 [[242, 495]] 1.0 4zog Homo sapiens TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7CC2A P00519 233 501 1130.0 FVC:601 Type1 Inactive DFGinter 9.165 8.2582 None -73.32, 112.44 -109.3, 64.01 -105.28, -20.44 309.47, 116.75 -109.01, 28.74 out-out out 11.0848 Saltbr-out 8.3686 HRD-in -90.34, -46.17 72.58, 0.36 out-out-in SNCooi out-in ActLoopNT-out 5.6175 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.21, 129.2 APE9-dihe-in -111.79, 156.63 APE8-dihe-in -66.39, 106.43 APE8-rot-na 344.92 APE67-dihe-in -73.87, -6.7 -58.13, -47.58 APE12-dist-na 19.2521 APE11-dist-na 14.4724 APE10-dist-na 17.3207 APE9-dist-in 6.8625 None None None XRAY 2.723 0.196 0.242 A 310.0 263.0 6 29 29 0 [[242, 495]] 1.0 7cc2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7CC2B P00519 232 501 1130.0 FVC:601 Type1 Inactive DFGinter 8.9786 8.607 None -71.77, 114.13 -110.49, 61.26 -109.45, -24.12 312.83, 116.95 -111.64, 29.87 in-none in 9.5409 Saltbr-none 999.0 HRD-in -88.51, -47.46 71.59, 1.41 none-out-in SNCnoi out-in ActLoopNT-out 5.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -97.35, 131.77 APE9-dihe-in -108.11, 154.53 APE8-dihe-in -67.24, 106.75 APE8-rot-na 21.35 APE67-dihe-in -74.13, -7.58 -57.65, -47.12 APE12-dist-na 19.1078 APE11-dist-na 14.3895 APE10-dist-na 17.5862 APE9-dist-in 7.0083 None None None XRAY 2.723 0.196 0.242 B 310.0 266.0 4 29 29 0 [[242, 495]] 1.0 7cc2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7DT2A P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.472 7.3955 None -67.36, 135.71 -126.94, 46.3 -101.94, -14.95 304.55, 98.79 -112.2, 27.67 in-out in 9.0003 Saltbr-out 3.7981 HRD-in -98.03, -51.7 81.6, -7.87 out-out-in SNCooi out-in ActLoopNT-out 5.7492 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.44, 133.63 APE9-dihe-in -118.19, 150.76 APE8-dihe-in -62.24, 99.73 APE8-rot-na 22.52 APE67-dihe-in -73.29, -7.91 -58.82, -45.37 APE12-dist-na 19.6063 APE11-dist-na 14.9562 APE10-dist-na 17.8178 APE9-dist-in 7.2588 None None None XRAY 2.3 0.208 0.237 A 310.0 265.0 3 29 29 0 [[242, 495]] 1.0 7dt2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 7DT2B P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.633 7.8528 None -67.09, 137.47 -125.9, 46.84 -103.12, -16.04 307.9, 99.91 -112.15, 26.28 in-out in 9.5935 Saltbr-out 4.0836 HRD-in -96.99, -47.74 84.36, -13.26 out-out-in SNCooi out-in ActLoopNT-out 5.563 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.22, 136.31 APE9-dihe-in -118.25, 150.94 APE8-dihe-in -59.92, 103.33 APE8-rot-na 21.91 APE67-dihe-in -72.55, -10.92 -57.38, -43.07 APE12-dist-na 18.6276 APE11-dist-na 13.9652 APE10-dist-na 17.3546 APE9-dist-in 6.6653 None None None XRAY 2.3 0.208 0.237 B 310.0 267.0 1 29 29 0 [[242, 495]] 1.0 7dt2 Homo sapiens TYR_ABL1_HUMAN TYR 3.6e-100 340.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G2HA P00519 233 504 1130.0 P16:60532 Type1 Inactive DFGinter 10.338 7.7628 None -69.8, 139.79 -117.08, 21.66 -74.78, -30.76 182.98, 70.09 -83.63, 27.99 in-out in 8.9475 Saltbr-out 8.4749 HRD-out -106.09, 125.25 -68.95, -15.96 out-out-in SNCooi out-in ActLoopNT-out 5.6222 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.55, 116.51 APE9-dihe-in -118.82, 162.2 APE8-dihe-in -67.24, 92.86 APE8-rot-na 32.82 APE67-dihe-in -70.58, -6.79 -39.4, -50.98 APE12-dist-na 19.9464 APE11-dist-na 15.2345 APE10-dist-na 17.2038 APE9-dist-in 6.5344 H396P None None XRAY 2.0 0.194 0.213 A 287.0 272.0 0 29 29 0 [[242, 495]] 1.0 2g2h Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4XEYA P00519 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.9273 None -70.89, 123.51 -90.91, 18.27 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.9479 Saltbr-out 8.6903 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.3933 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.7302 APE11-dist-na 14.1077 APE10-dist-na 16.5419 APE9-dist-in 6.5879 None None None XRAY 2.891 0.232 0.259 A 408.0 269.0 4 29 29 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.5e-100 339.5 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8I7ZA P00519 232 499 1130.0 6CI:601,BAL:602 Type1,Type1 Inactive DFGinter 8.675 7.469 None -68.15, 124.34 -115.26, 44.89 -92.28, -20.89 299.64, 92.88 -113.55, 33.09 in-none in 9.0131 Saltbr-none 999.0 HRD-in -101.45, -51.38 75.46, -1.93 none-out-in SNCnoi out-in ActLoopNT-out 5.7346 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.91, 129.83 APE9-dihe-in -107.25, 158.29 APE8-dihe-in -77.21, 88.15 APE8-rot-na 26.6 APE67-dihe-in -78.48, -3.49 -49.13, -44.82 APE12-dist-na 19.9913 APE11-dist-na 15.3458 APE10-dist-na 18.0738 APE9-dist-in 7.5127 None PTR393 PTR393 XRAY 2.255 0.177 0.213 A 272.0 258.0 10 29 29 0 [[242, 495]] 1.0 8i7z Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4YC8A P00519 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.2536 9.4795 None -68.71, 128.66 -122.3, 46.03 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.1416 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.4398 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.1265 APE11-dist-na 14.4499 APE10-dist-na 17.471 APE9-dist-in 6.7471 None None None XRAY 2.9 0.199 0.24 A 287.0 259.0 10 29 29 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4YC8B P00519 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.5551 9.6924 None -74.12, 129.26 -121.25, 39.81 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.8223 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.4443 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.6692 APE11-dist-na 14.9891 APE10-dist-na 17.7851 APE9-dist-in 6.9304 None None None XRAY 2.9 0.199 0.24 B 287.0 264.0 6 29 29 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 9KS5A P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.7305 5.5961 None -72.67, 142.35 -137.94, 44.53 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.0052 Saltbr-na 6.5449 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.8077 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.8189 APE11-dist-na 15.2479 APE10-dist-na 18.1002 APE9-dist-in 7.5449 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272.0 267.0 1 29 29 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 9KS5B P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.9707 5.8466 None -69.26, 149.18 -127.32, 25.05 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.9604 Saltbr-na 6.2903 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.4644 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.4239 APE11-dist-na 14.0576 APE10-dist-na 17.2646 APE9-dist-in 6.8918 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272.0 268.0 0 29 29 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.6e-98 335.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6XRGA P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.0059 8.6965 BBAminus -171.83, 165.33 -155.54, 133.54 -84.4, -28.08 302.76, 128.31 104.78, 35.25 in-in in 8.0626 Saltbr-in 3.1402 HRD-in -67.57, -50.13 76.12, -27.45 in-out-out SNCioo out-out ActLoopNT-out 18.4136 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -124.03, 17.56 APE9-dihe-in -95.78, 148.38 APE8-dihe-in -59.62, 96.75 APE8-rot-na 336.69 APE67-dihe-in -65.49, -36.89 -72.8, -27.02 APE12-dist-na 14.3999 APE11-dist-na 13.4574 APE10-dist-na 9.2109 APE9-dist-in 6.3602 G250E,M290L,T389Y None None NMR 999.0 999.0 999.0 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 6xrg Homo sapiens TYR_ABL1_HUMAN TYR 1.3e-100 341.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3QRJA P00519 234 496 1130.0 919:2 Type2 Inactive DFGout 13.1495 8.9896 BBAminus -140.1, 177.46 -140.75, 104.13 -86.94, 4.73 283.88, 85.78 63.32, 48.64 in-in in 7.6735 Saltbr-in 2.7754 HRD-in -79.02, -49.06 80.26, -14.09 in-out-in SNCioi out-in ActLoopNT-out 14.9879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -90.38, 130.47 APE9-dihe-in -139.16, 150.69 APE8-dihe-in -78.39, 79.63 APE8-rot-na 34.62 APE67-dihe-in -72.48, -9.29 -46.12, -53.19 APE12-dist-na 18.622 APE11-dist-na 15.6447 APE10-dist-na 10.8448 APE9-dist-in 7.3579 T315I None None XRAY 1.82 0.232 0.286 A 277.0 258.0 5 29 29 0 [[242, 495]] 1.0 3qrj Homo sapiens TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3QRJB P00519 233 497 1130.0 919:1 Type2 Inactive DFGout 13.1286 9.0788 BBAminus -139.41, 169.11 -133.48, 106.22 -82.14, 0.45 283.14, 89.48 61.09, 48.15 in-in in 7.9313 Saltbr-in 2.7953 HRD-in -78.78, -56.83 82.44, -6.52 in-out-in SNCioi out-in ActLoopNT-out 15.1049 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.29, 121.26 APE9-dihe-in -134.93, 153.91 APE8-dihe-in -77.7, 85.51 APE8-rot-na 33.76 APE67-dihe-in -63.53, -18.09 -55.44, -46.47 APE12-dist-na 18.6564 APE11-dist-na 15.3761 APE10-dist-na 10.8226 APE9-dist-in 7.7219 T315I None None XRAY 1.82 0.232 0.286 B 277.0 265.0 0 29 29 0 [[242, 495]] 1.0 3qrj Homo sapiens TYR_ABL1_HUMAN TYR 4.7e-100 340.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HZ0A P00519 233 497 1130.0 GIN:600 Type2 Inactive DFGout 16.3147 10.4751 BBAminus -150.83, -160.56 -160.34, 120.0 -81.87, -18.31 276.95, 79.02 -92.52, 170.28 in-in in 7.814 Saltbr-in 2.6962 HRD-in -75.66, -51.7 79.36, -13.13 in-out-in SNCioi out-in ActLoopNT-out 6.647 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.12, 134.88 APE9-dihe-in -108.63, 131.61 APE8-dihe-in -62.36, 119.6 APE8-rot-na 29.91 APE67-dihe-in -70.7, -20.49 -52.84, -40.81 APE12-dist-na 12.4615 APE11-dist-na 9.6029 APE10-dist-na 12.5475 APE9-dist-in 6.1546 None None None XRAY 2.1 0.195 0.256 A 270.0 265.0 0 29 29 0 [[242, 495]] 1.0 2hz0 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HZ0B P00519 228 497 1130.0 GIN:600 Type2 Inactive DFGout 16.1446 10.2879 BBAminus -144.12, -165.06 -157.27, 107.1 -67.75, -17.6 276.47, 79.62 51.54, 32.42 in-in in 7.8512 Saltbr-in 2.5019 HRD-in -77.02, -51.65 87.26, -10.24 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.38 APE8-rot-na 355.54 APE67-dihe-in -66.19, -16.4 -42.69, -41.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.195 0.256 B 270.0 243.0 27 29 12 17 [[242, 495]] 1.0 2hz0 Homo sapiens TYR_ABL1_HUMAN TYR 2.1e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HYYA P00519 235 498 1130.0 STI:600 Type2 Inactive DFGout 13.4478 10.9363 BBAminus -136.71, -169.54 -156.86, 107.67 -99.35, 1.46 307.94, 127.18 66.47, 52.08 in-in in 8.2395 Saltbr-in 3.0042 HRD-in -68.42, -63.13 91.16, -9.54 in-out-in SNCioi out-in ActLoopNT-out 16.0994 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.4, 131.38 APE9-dihe-in -122.46, 141.0 APE8-dihe-in -82.09, 92.82 APE8-rot-na 22.51 APE67-dihe-in -74.51, -8.92 -44.66, -47.4 APE12-dist-na 14.4582 APE11-dist-na 11.9011 APE10-dist-na 8.4151 APE9-dist-in 7.3935 None None None XRAY 2.4 0.208 0.267 A 273.0 263.0 1 29 29 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HYYB P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6073 10.8376 BBAminus -140.46, -179.87 -145.37, 104.9 -88.0, -4.17 302.17, 134.32 68.19, 47.44 in-in in 8.468 Saltbr-in 2.9739 HRD-in -72.33, -53.74 81.02, -14.85 in-out-in SNCioi out-in ActLoopNT-out 15.7155 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.08, 127.85 APE9-dihe-in -116.06, 145.63 APE8-dihe-in -88.84, 91.14 APE8-rot-na 22.78 APE67-dihe-in -77.2, -5.94 -46.52, -42.21 APE12-dist-na 14.4786 APE11-dist-na 11.9487 APE10-dist-na 8.4213 APE9-dist-in 7.4165 None None None XRAY 2.4 0.208 0.267 B 273.0 265.0 1 29 29 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HYYC P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.817 11.1447 BBAminus -136.58, -170.43 -156.15, 102.72 -91.16, -2.19 306.71, 138.1 61.3, 49.16 in-in in 8.2912 Saltbr-in 3.4095 HRD-in -75.29, -48.77 83.65, -17.42 in-out-in SNCioi out-in ActLoopNT-out 15.6362 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.7, 128.89 APE9-dihe-in -132.69, 141.39 APE8-dihe-in -86.44, 89.34 APE8-rot-na 30.23 APE67-dihe-in -75.71, -10.45 -48.99, -40.28 APE12-dist-na 15.6276 APE11-dist-na 13.5323 APE10-dist-na 8.7762 APE9-dist-in 7.5146 None None None XRAY 2.4 0.208 0.267 C 273.0 262.0 4 29 26 3 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HYYD P00519 233 498 1130.0 STI:600 Type2 Inactive DFGout 13.6269 11.0079 BBAminus -135.11, -170.82 -155.12, 109.43 -96.64, 9.5 309.68, 132.23 60.03, 43.1 in-in in 8.0089 Saltbr-in 2.7581 HRD-in -69.95, -55.57 86.15, -21.95 in-out-in SNCioi out-in ActLoopNT-out 15.3354 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.41, 121.23 APE9-dihe-in -126.0, 140.68 APE8-dihe-in -79.93, 90.29 APE8-rot-na 35.26 APE67-dihe-in -80.44, -14.01 -57.15, -31.16 APE12-dist-na 15.6748 APE11-dist-na 13.4748 APE10-dist-na 8.574 APE9-dist-in 7.5548 None None None XRAY 2.4 0.208 0.267 D 273.0 264.0 2 29 29 0 [[242, 495]] 1.0 2hyy Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3CS9A P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.5926 11.1183 BBAminus -145.37, -175.21 -153.52, 95.68 -79.44, 2.63 308.67, 139.53 60.14, 48.09 in-in in 7.9872 Saltbr-in 2.9586 HRD-in -72.5, -52.05 83.05, -14.51 in-out-in SNCioi out-in ActLoopNT-out 15.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.13, 125.61 APE9-dihe-in -114.38, 144.88 APE8-dihe-in -83.08, 84.52 APE8-rot-na 33.34 APE67-dihe-in -71.16, -7.94 -52.7, -43.38 APE12-dist-na 15.6378 APE11-dist-na 11.341 APE10-dist-na 8.5859 APE9-dist-in 7.762 None None None XRAY 2.21 0.2 0.242 A 277.0 264.0 4 29 29 0 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3CS9B P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.4559 10.7526 BBAminus -144.0, -176.67 -148.15, 110.4 -103.8, 0.8 309.16, 135.76 150.34, 999.0 in-in in 8.2215 Saltbr-in 3.4798 HRD-in -70.96, -54.76 81.36, -12.94 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.55 APE8-rot-na 31.92 APE67-dihe-in -70.26, -17.41 -42.99, -45.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 B 277.0 247.0 21 29 11 18 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3CS9C P00519 232 497 1130.0 NIL:600 Type2 Inactive DFGout 13.7124 10.9182 BBAminus -141.39, 177.78 -141.43, 100.61 -84.1, -4.94 304.15, 138.08 61.69, 999.0 in-in in 7.9551 Saltbr-in 2.8283 HRD-in -74.87, -48.82 81.89, -13.85 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.51 APE8-rot-na 36.98 APE67-dihe-in -69.35, -10.43 -43.96, -42.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.21 0.2 0.242 C 277.0 243.0 23 29 11 18 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3CS9D P00519 233 500 1130.0 NIL:600 Type2 Inactive DFGout 13.7784 11.7574 BBAminus -137.25, -170.7 -151.81, 104.77 -89.11, 0.3 306.25, 137.53 63.13, 44.73 in-in in 7.8883 Saltbr-in 2.7404 HRD-in -68.82, -44.23 79.28, -14.07 in-out-in SNCioi out-in ActLoopNT-out 15.5902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.05, 117.02 APE9-dihe-in -109.67, 147.03 APE8-dihe-in -87.1, 85.65 APE8-rot-na 29.26 APE67-dihe-in -63.61, -19.67 -51.69, -46.78 APE12-dist-na 16.1499 APE11-dist-na 12.1503 APE10-dist-na 8.7581 APE9-dist-in 7.5814 None None None XRAY 2.21 0.2 0.242 D 277.0 263.0 5 29 29 0 [[242, 495]] 1.0 3cs9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3QRIA P00519 229 498 1130.0 919:60500 Type2 Inactive DFGout 13.4048 9.244 BBAminus -140.23, -177.67 -143.73, 111.06 -85.62, -1.21 285.71, 95.83 64.84, 45.13 in-in in 7.938 Saltbr-in 2.6713 HRD-in -68.59, -54.98 84.86, -16.08 in-out-in SNCioi out-in ActLoopNT-out 15.3297 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -92.68, 128.64 APE9-dihe-in -141.86, 154.54 APE8-dihe-in -79.64, 85.81 APE8-rot-na 26.51 APE67-dihe-in -72.47, -7.02 -44.71, -48.72 APE12-dist-na 18.4987 APE11-dist-na 15.5857 APE10-dist-na 10.7258 APE9-dist-in 7.4255 None None None XRAY 2.1 0.216 0.272 A 277.0 270.0 0 29 29 0 [[242, 495]] 1.0 3qri Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3QRIB P00519 232 498 1130.0 919:60002 Type2 Inactive DFGout 13.3944 9.3548 BBAminus -137.99, -177.06 -143.59, 113.56 -88.43, -2.03 287.13, 98.7 64.72, 47.42 in-in in 7.8509 Saltbr-in 2.8565 HRD-in -75.25, -51.53 85.01, -17.97 in-out-in SNCioi out-in ActLoopNT-out 15.3271 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.54, 128.19 APE9-dihe-in -140.43, 156.29 APE8-dihe-in -80.95, 78.25 APE8-rot-na 29.21 APE67-dihe-in -73.74, -7.02 -42.67, -45.53 APE12-dist-na 18.487 APE11-dist-na 15.5621 APE10-dist-na 10.7895 APE9-dist-in 7.4803 None None None XRAY 2.1 0.216 0.272 B 277.0 262.0 5 29 29 0 [[242, 495]] 1.0 3qri Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HIWA P00519 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.3473 10.8265 BBAminus -142.71, -168.33 -158.01, 107.74 -97.35, 2.37 312.36, 126.58 65.32, 50.81 in-out in 8.2289 Saltbr-out 3.7404 HRD-in -73.86, -48.39 84.66, -24.64 out-out-in SNCooi out-in ActLoopNT-out 15.6369 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.28, 130.36 APE9-dihe-in -115.68, 135.96 APE8-dihe-in -85.15, 68.17 APE8-rot-na 24.2 APE67-dihe-in -72.17, -12.42 -32.25, -48.66 APE12-dist-na 13.5733 APE11-dist-na 12.4749 APE10-dist-na 8.1904 APE9-dist-in 7.7237 None None None XRAY 2.2 0.246 0.309 A 287.0 270.0 0 29 29 0 [[242, 495]] 1.0 2hiw Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HIWB P00519 230 499 1130.0 7MP:60531 Type2 Inactive DFGout 13.0877 11.2071 BBAminus -144.46, -168.71 -161.12, 102.71 -97.39, 4.98 318.67, 117.06 56.31, 54.08 in-in in 8.0153 Saltbr-in 2.7868 HRD-in -67.44, -50.02 79.19, -15.91 in-out-in SNCioi out-in ActLoopNT-out 15.9652 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -73.79, 117.59 APE9-dihe-in -110.67, 133.98 APE8-dihe-in -80.14, 91.72 APE8-rot-na 27.82 APE67-dihe-in -76.13, -9.39 -64.08, -40.93 APE12-dist-na 14.6952 APE11-dist-na 12.5191 APE10-dist-na 8.4947 APE9-dist-in 7.6721 None None None XRAY 2.2 0.246 0.309 B 287.0 270.0 0 29 29 0 [[242, 495]] 1.0 2hiw Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2E2BA P00519 229 502 1130.0 406:61001 Type2 Inactive DFGout 13.6369 10.9141 BBAminus -135.1, -171.45 -153.85, 101.44 -92.52, 5.9 308.25, 136.28 52.63, 55.21 in-in in 8.4387 Saltbr-in 2.958 HRD-in -72.49, -53.7 81.83, -19.66 in-out-in SNCioi out-in ActLoopNT-out 15.4827 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.77, 121.49 APE9-dihe-in -121.85, 146.58 APE8-dihe-in -80.67, 88.23 APE8-rot-na 34.75 APE67-dihe-in -71.79, -9.02 -46.22, -43.83 APE12-dist-na 15.609 APE11-dist-na 11.3547 APE10-dist-na 8.5173 APE9-dist-in 7.2711 None None None XRAY 2.2 0.236 0.27 A 293.0 266.0 8 29 25 4 [[242, 495]] 1.0 2e2b Homo sapiens TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2E2BB P00519 229 497 1130.0 406:61002 Type2 Inactive DFGout 13.647 10.9332 BBAminus -143.5, -176.35 -149.87, 101.4 -87.9, 0.31 305.42, 141.47 55.35, 49.49 in-in in 8.4517 Saltbr-in 2.8516 HRD-in -72.44, -52.01 77.65, -14.12 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.83, 116.83 APE9-dihe-in -124.88, 142.96 APE8-dihe-in -78.59, 83.23 APE8-rot-na 29.89 APE67-dihe-in -65.0, -9.5 -42.19, -50.29 APE12-dist-na 15.6557 APE11-dist-na 11.8314 APE10-dist-na 8.4692 APE9-dist-in 7.2202 None None None XRAY 2.2 0.236 0.27 B 293.0 258.0 11 29 23 6 [[242, 495]] 1.0 2e2b Homo sapiens TYR_ABL1_HUMAN TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 5HU9A P00519 229 499 1130.0 66K:60601,66K:60602 Type2,Allosteric Inactive DFGout 15.803 10.497 BBAminus -145.4, -177.31 -141.71, 111.16 -69.31, -26.01 283.1, 65.03 93.44, 13.86 in-in in 8.0827 Saltbr-in 2.7689 HRD-in -68.36, -51.36 83.46, -11.3 in-out-out SNCioo out-out ActLoopNT-out 13.3135 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -72.36, -42.02 APE9-dihe-in -132.05, 79.59 APE8-dihe-in -81.54, 66.0 APE8-rot-na 26.81 APE67-dihe-in -69.94, -12.93 -59.43, -37.79 APE12-dist-na 9.5095 APE11-dist-na 5.4553 APE10-dist-na 6.0943 APE9-dist-out 9.516 None None None XRAY 1.529 0.186 0.196 A 277.0 266.0 5 29 24 5 [[242, 495]] 1.0 5hu9 Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3PYYA P00519 232 500 1130.0 STI:60003,3YY:60538 Type2,Allosteric Inactive DFGout 13.6472 11.2623 BBAminus -130.42, -173.45 -148.82, 100.51 -87.29, -2.92 301.78, 132.98 62.26, 50.77 in-in in 8.1427 Saltbr-in 2.677 HRD-in -77.84, -60.13 91.69, -13.02 in-out-in SNCioi out-in ActLoopNT-out 15.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.57, 117.7 APE9-dihe-in -121.79, 141.76 APE8-dihe-in -85.05, 87.91 APE8-rot-na 30.64 APE67-dihe-in -73.12, -6.21 -47.76, -45.73 APE12-dist-na 16.5248 APE11-dist-na 12.81 APE10-dist-na 8.6957 APE9-dist-in 7.7291 None None None XRAY 1.85 0.189 0.204 A 298.0 265.0 4 29 29 0 [[242, 495]] 1.0 3pyy Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3PYYB P00519 233 510 1130.0 STI:60004,3YY:60532 Type2,Allosteric Inactive DFGout 13.9702 11.0172 BBAminus -132.59, -172.42 -152.94, 105.37 -94.38, -50.82 313.04, 135.61 93.2, 999.0 in-in in 8.1 Saltbr-in 2.5706 HRD-in -81.0, -57.03 86.3, -14.2 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -127.99, 138.02 APE9-dihe-in -152.66, 146.9 APE8-dihe-in -80.16, 79.64 APE8-rot-na 29.64 APE67-dihe-in -75.32, -11.37 -49.83, -39.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.258 None None None XRAY 1.85 0.189 0.204 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 3pyy Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6NPEA P00519 232 500 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.751 11.2768 BBAminus -132.09, -171.87 -150.82, 100.43 -86.72, -1.03 301.5, 131.9 61.32, 51.13 in-in in 8.1711 Saltbr-in 2.7788 HRD-in -75.05, -56.53 78.97, -9.5 in-out-in SNCioi out-in ActLoopNT-out 15.7357 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.77, 121.63 APE9-dihe-in -123.35, 140.69 APE8-dihe-in -84.02, 84.76 APE8-rot-na 23.95 APE67-dihe-in -76.42, -6.93 -49.4, -44.5 APE12-dist-na 16.5922 APE11-dist-na 12.7878 APE10-dist-na 8.7525 APE9-dist-in 7.8443 None None None XRAY 2.15 0.187 0.212 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npe Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6NPEB P00519 233 511 1130.0 STI:60603,KWD:60604 Type2,Allosteric Inactive DFGout 13.8401 11.1015 BBAminus -129.89, -169.38 -152.66, 105.04 -92.73, -27.9 303.95, 134.44 82.3, 999.0 in-in in 8.2217 Saltbr-in 2.6842 HRD-in -80.48, -54.98 79.49, -7.09 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.9 APE8-dihe-in -75.88, 86.79 APE8-rot-na 23.52 APE67-dihe-in -70.62, -18.32 -51.39, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6859 None None None XRAY 2.15 0.187 0.212 B 298.0 256.0 23 29 12 17 [[242, 495]] 1.0 6npe Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6NPUA P00519 232 500 1130.0 STI:60601,KWV:60602 Type2,Allosteric Inactive DFGout 13.7239 11.3407 BBAminus -131.32, -177.82 -147.63, 103.5 -91.61, -2.68 302.6, 133.1 64.49, 56.03 in-in in 8.1753 Saltbr-in 2.6429 HRD-in -76.28, -58.38 85.82, -8.07 in-out-in SNCioi out-in ActLoopNT-out 15.709 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 129.98 APE9-dihe-in -123.79, 139.52 APE8-dihe-in -78.9, 90.13 APE8-rot-na 28.21 APE67-dihe-in -75.75, -3.63 -52.56, -44.81 APE12-dist-na 16.3124 APE11-dist-na 12.5979 APE10-dist-na 8.715 APE9-dist-in 7.8012 None None None XRAY 2.33 0.196 0.234 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npu Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6NPUB P00519 233 510 1130.0 STI:60602,KWV:60605 Type2,Allosteric Inactive DFGout 13.7158 11.1215 BBAminus -136.03, -173.76 -148.73, 104.54 -94.68, -39.85 309.09, 136.14 93.88, 999.0 in-in in 8.0462 Saltbr-in 2.6551 HRD-in -88.42, -57.18 82.99, -10.02 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.51, 88.48 APE9-dihe-in -97.46, 155.87 APE8-dihe-in -87.38, 82.63 APE8-rot-na 29.77 APE67-dihe-in -64.85, -22.06 -45.68, -43.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8546 None None None XRAY 2.33 0.196 0.234 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npu Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6NPVA P00519 232 500 1130.0 STI:60602,KWP:60603 Type2,Allosteric Inactive DFGout 13.575 11.2109 BBAminus -133.43, -176.32 -147.26, 102.27 -88.44, -2.86 301.02, 133.29 64.03, 50.03 in-in in 8.1581 Saltbr-in 2.9685 HRD-in -74.61, -59.03 88.55, -10.34 in-out-in SNCioi out-in ActLoopNT-out 15.7382 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.7, 120.65 APE9-dihe-in -115.73, 140.1 APE8-dihe-in -81.63, 87.3 APE8-rot-na 30.14 APE67-dihe-in -75.75, -5.01 -52.83, -44.97 APE12-dist-na 16.3027 APE11-dist-na 12.2839 APE10-dist-na 8.7127 APE9-dist-in 7.7824 None None None XRAY 1.86 0.183 0.207 A 298.0 264.0 5 29 29 0 [[242, 495]] 1.0 6npv Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6NPVB P00519 233 510 1130.0 STI:60603,KWP:60607 Type2,Allosteric Inactive DFGout 13.5449 11.0623 BBAminus -135.7, -168.07 -155.88, 101.76 -93.13, -7.53 306.52, 136.97 78.01, 999.0 in-in in 8.2003 Saltbr-in 2.7509 HRD-in -76.84, -57.95 84.26, -8.39 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.75, 102.42 APE9-dihe-in -114.18, 151.63 APE8-dihe-in -86.78, 85.36 APE8-rot-na 20.0 APE67-dihe-in -75.22, -6.58 -51.86, -43.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9656 None None None XRAY 1.86 0.183 0.207 B 298.0 257.0 21 29 14 15 [[242, 495]] 1.0 6npv Homo sapiens TYR_ABL1_HUMAN TYR 3.1e-100 340.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3QRKA P00519 229 496 1130.0 9DP:60001 Type3 Inactive DFGout 13.5376 9.2632 BBAminus -128.74, -174.73 -147.03, 106.14 -83.7, 8.0 281.11, 96.68 56.22, 46.71 in-in in 7.8529 Saltbr-in 2.6737 HRD-in -77.83, -51.71 87.8, -21.18 in-out-in SNCioi out-in ActLoopNT-out 15.3027 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.14, 132.07 APE9-dihe-in -145.7, 147.79 APE8-dihe-in -79.52, 88.76 APE8-rot-na 26.7 APE67-dihe-in -65.94, -15.53 -54.88, -43.49 APE12-dist-na 18.8146 APE11-dist-na 15.7582 APE10-dist-na 10.9913 APE9-dist-in 7.5852 None None None XRAY 2.3 0.192 0.281 A 277.0 268.0 0 29 29 0 [[242, 495]] 1.0 3qrk Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G2FB P00519 234 502 1130.0 AGS:601 ATPlike Inactive DFGout 13.4774 11.5253 None -73.05, 151.22 -78.4, -31.56 -2.81, -74.15 167.03, 54.1 -90.78, 24.63 in-in in 8.8964 Saltbr-in 3.3728 HRD-out -112.09, 115.32 -73.34, -1.05 in-out-in SNCioi out-in ActLoopNT-out 5.759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.67, 144.36 APE9-dihe-in -134.57, 156.36 APE8-dihe-in -59.22, 104.92 APE8-rot-na 31.18 APE67-dihe-in -59.35, -15.8 -52.01, -51.94 APE12-dist-na 18.8868 APE11-dist-na 14.2996 APE10-dist-na 17.6873 APE9-dist-in 6.8177 H396P None None XRAY 2.7 0.234 0.286 B 287.0 264.0 5 29 29 0 [[242, 495]] 1.0 2g2f Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 6XR7A P00519 229 515 1130.0 No_ligand No_ligand Inactive DFGout 12.4425 8.628 None -113.31, -174.74 -119.02, 30.04 -65.72, 104.77 191.29, 77.0 102.04, -118.08 in-in in 7.642 Saltbr-in 2.805 HRD-in -104.45, -51.55 70.39, 1.66 in-out-out SNCioo out-out ActLoopNT-out 4.9623 ActLoopCT-out TYR APEdihe_ooiai APEdist_aaai APE10-dihe-out 60.98, -93.15 APE9-dihe-out 55.27, 119.08 APE8-dihe-in -62.33, 109.76 APE8-rot-na 22.3 APE67-dihe-in -67.97, -13.01 -57.05, -38.83 APE12-dist-na 12.2575 APE11-dist-na 9.5131 APE10-dist-na 11.2076 APE9-dist-in 7.7064 None None None NMR 999.0 999.0 999.0 A 287.0 287.0 0 29 29 0 [[242, 495]] 1.0 6xr7 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8I7TB P00519 232 500 1130.0 6I5:601 Type1 Inactive DFGout 13.4131 11.662 None -78.21, 133.76 -76.1, -34.26 58.37, -123.75 266.71, 82.63 -125.63, 98.01 in-in in 9.5758 Saltbr-in 3.2593 HRD-in -106.12, -52.02 70.25, 2.56 in-out-in SNCioi out-in ActLoopNT-out 5.657 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.56, 141.45 APE9-dihe-in -118.71, 149.22 APE8-dihe-in -71.44, 98.5 APE8-rot-na 25.12 APE67-dihe-in -70.33, -18.58 -57.67, -41.4 APE12-dist-na 18.1415 APE11-dist-na 13.5979 APE10-dist-na 16.9845 APE9-dist-in 6.8506 None PTR393 PTR393 XRAY 2.8 0.221 0.272 B 272.0 263.0 6 29 29 0 [[242, 495]] 1.0 8i7t Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HZIA P00519 233 500 1130.0 JIN:600 Type1 Inactive DFGout 12.6724 11.025 None -64.65, 136.57 -117.47, 21.9 -67.4, 155.9 48.8, 72.68 74.75, 2.18 in-in in 8.0101 Saltbr-in 2.7508 HRD-in -100.41, -50.8 74.37, -4.5 in-out-in SNCioi out-in ActLoopNT-out 5.6021 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.67, 131.39 APE9-dihe-in -115.42, 162.87 APE8-dihe-in -80.35, 88.85 APE8-rot-na 20.47 APE67-dihe-in -70.91, -11.25 -48.9, -44.37 APE12-dist-na 19.4441 APE11-dist-na 14.8564 APE10-dist-na 17.6914 APE9-dist-in 7.1792 None None None XRAY 1.7 0.177 0.204 A 277.0 268.0 0 29 29 0 [[242, 495]] 1.0 2hzi Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4ZOGB P00519 234 503 1130.0 VX6:601 Type1 Inactive DFGout 11.7889 11.8279 None -72.45, 126.77 -115.82, 44.9 -59.71, -111.34 30.08, 49.18 -63.43, 48.35 in-in in 8.8801 Saltbr-in 3.108 HRD-in -92.87, -52.54 77.42, -2.86 in-out-in SNCioi out-in ActLoopNT-out 5.5005 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.26, 120.92 APE9-dihe-in -100.0, 141.29 APE8-dihe-in -74.27, 97.66 APE8-rot-na 25.54 APE67-dihe-in -72.2, -10.54 -59.59, -40.07 APE12-dist-na 17.8557 APE11-dist-na 13.8579 APE10-dist-na 16.2066 APE9-dist-in 6.9896 None None None XRAY 2.3 0.187 0.233 B 283.0 268.0 2 29 27 2 [[242, 495]] 1.0 4zog Homo sapiens TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4WA9B P00519 246 508 1130.0 AXI:69000 Type1 Inactive DFGout 13.3112 10.2815 None -75.93, 149.51 -77.88, -15.66 -59.19, 118.14 191.81, 69.86 106.96, -1.52 in-in in 7.643 Saltbr-in 2.0564 HRD-out -116.7, 121.02 -81.78, -7.12 in-out-in SNCioi out-in ActLoopNT-out 5.3274 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -127.35, 121.29 APE9-dihe-in -115.41, 155.9 APE8-dihe-in -66.84, 110.63 APE8-rot-na 32.52 APE67-dihe-in -70.78, -12.55 -43.03, -46.3 APE12-dist-na 18.4998 APE11-dist-na 13.938 APE10-dist-na 17.4982 APE9-dist-in 6.7106 None None None XRAY 2.2 0.175 0.212 B 286.0 263.0 0 29 29 0 [[242, 495]] 1.0 4wa9 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3UE4A P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.4713 10.0872 None -73.57, 139.68 -129.47, 18.74 -70.04, -27.22 71.97, 85.11 -97.86, 45.9 in-out in 8.1219 Saltbr-out 4.0052 HRD-out -105.15, 128.48 -83.8, -2.91 out-out-in SNCooi out-in ActLoopNT-out 5.2939 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -98.88, 137.39 APE9-dihe-in -119.63, 157.7 APE8-dihe-in -69.93, 97.57 APE8-rot-na 25.4 APE67-dihe-in -65.99, -15.91 -45.97, -49.68 APE12-dist-na 19.2109 APE11-dist-na 14.4694 APE10-dist-na 17.1224 APE9-dist-in 6.8357 None None None XRAY 2.424 0.192 0.249 A 287.0 270.0 0 29 29 0 [[242, 495]] 1.0 3ue4 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 3UE4B P00519 233 502 1130.0 DB8:601 Type1 Inactive DFGout 11.2239 10.4796 None -68.43, 143.68 -139.88, 24.33 -73.48, -36.67 65.16, 97.6 -93.69, 7.14 in-out in 8.4914 Saltbr-out 3.7707 HRD-in -88.28, -56.6 76.68, -0.41 out-out-in SNCooi out-in ActLoopNT-out 5.4413 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.79, 122.21 APE9-dihe-in -108.43, 151.01 APE8-dihe-in -71.16, 105.45 APE8-rot-na 24.97 APE67-dihe-in -72.18, -12.67 -59.58, -44.17 APE12-dist-na 19.4531 APE11-dist-na 14.7482 APE10-dist-na 17.2117 APE9-dist-in 6.8924 None None None XRAY 2.424 0.192 0.249 B 287.0 268.0 2 29 29 0 [[242, 495]] 1.0 3ue4 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 8I7TA P00519 232 500 1130.0 6I5:601 Type1.5_Back Inactive DFGout 13.2636 11.9557 None -62.98, 128.57 -72.85, -7.53 36.94, -135.32 264.95, 6.34 101.46, 15.06 in-in in 8.5956 Saltbr-in 3.2755 HRD-in -96.98, -47.23 68.77, 7.6 in-out-in SNCioi out-in ActLoopNT-out 5.8528 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.95, 130.91 APE9-dihe-in -108.03, 159.47 APE8-dihe-in -73.45, 92.08 APE8-rot-na 23.57 APE67-dihe-in -76.01, -8.31 -52.5, -40.25 APE12-dist-na 19.7336 APE11-dist-na 15.1378 APE10-dist-na 18.0684 APE9-dist-in 7.3114 None PTR393 PTR393 XRAY 2.8 0.221 0.272 A 272.0 267.0 2 29 29 0 [[242, 495]] 1.0 8i7t Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2HZIB P00519 233 500 1130.0 JIN:600 Type1.5_Back Inactive DFGout 12.6514 10.8001 None -64.82, 139.58 -123.5, 22.46 -72.33, 154.15 44.58, 70.92 81.45, -10.45 in-in in 8.0484 Saltbr-in 2.7877 HRD-in -103.52, -56.2 76.53, -2.92 in-out-in SNCioi out-in ActLoopNT-out 5.5339 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.65, 133.63 APE9-dihe-in -122.59, 157.35 APE8-dihe-in -72.25, 93.6 APE8-rot-na 22.08 APE67-dihe-in -66.73, -17.62 -46.65, -45.74 APE12-dist-na 19.118 APE11-dist-na 14.4068 APE10-dist-na 17.1847 APE9-dist-in 6.7955 None None None XRAY 1.7 0.177 0.204 B 277.0 264.0 4 29 29 0 [[242, 495]] 1.0 2hzi Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2G2HB P00519 233 504 1130.0 P16:60532 Type1.5_Back Inactive DFGout 12.6989 10.5001 None -60.13, 139.26 -82.96, -16.55 -75.2, 165.15 55.98, 67.58 79.14, 12.62 in-out in 8.1928 Saltbr-out 6.8591 HRD-out -104.81, 126.85 -89.37, -5.07 out-out-in SNCooi out-in ActLoopNT-out 5.4813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.1, 135.12 APE9-dihe-in -121.36, 158.85 APE8-dihe-in -60.74, 105.18 APE8-rot-na 332.86 APE67-dihe-in -67.82, -12.38 -45.03, -49.81 APE12-dist-na 18.6686 APE11-dist-na 13.9016 APE10-dist-na 17.2439 APE9-dist-in 6.55 H396P None None XRAY 2.0 0.194 0.213 B 287.0 272.0 0 29 29 0 [[242, 495]] 1.0 2g2h Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 2FO0A P00519 46 511 1130.0 P16:60702 Type1.5_Back Inactive DFGout 13.4469 11.7849 None -76.52, 118.23 -95.45, 43.06 -89.94, 155.29 62.25, 72.76 62.2, 26.15 in-in in 8.0548 Saltbr-in 3.1541 HRD-in -101.49, -60.91 80.44, -3.96 in-out-in SNCioi out-in ActLoopNT-out 5.7625 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.77, 155.96 APE9-dihe-in -130.48, 150.83 APE8-dihe-in -76.1, 87.73 APE8-rot-na 30.01 APE67-dihe-in -55.48, -20.39 -31.31, -58.23 APE12-dist-na 19.757 APE11-dist-na 15.0519 APE10-dist-na 18.0531 APE9-dist-in 7.2256 D363N SEP50 SEP50 XRAY 2.27 0.21 0.246 A 495.0 466.0 0 29 29 0 [[242, 495]] 1.0 2fo0 Homo sapiens TYR_ABL1_HUMAN TYR 5.5e-99 337.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 1OPLA P00519 62 512 1130.0 P16:60539 Type1.5_Back Inactive DFGout 12.8079 11.6702 None -65.59, 134.14 -116.03, 33.28 -83.5, 159.91 53.21, 70.33 67.06, 8.01 in-in in 7.9532 Saltbr-in 2.9441 HRD-in -97.12, -53.99 73.72, -6.86 in-out-in SNCioi out-in ActLoopNT-out 5.5535 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.98, 127.83 APE9-dihe-in -117.56, 161.51 APE8-dihe-in -80.15, 93.03 APE8-rot-na 30.65 APE67-dihe-in -63.53, -19.0 -41.82, -48.43 APE12-dist-na 19.4826 APE11-dist-na 14.757 APE10-dist-na 17.4347 APE9-dist-in 7.1249 K12R,D363N None None XRAY 3.42 0.306 0.315 A 537.0 451.0 0 29 29 0 [[242, 495]] 1.0 1opl Homo sapiens TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 1OPLB P00519 121 499 1130.0 P16:60538 Type1.5_Back Inactive DFGout 12.1961 11.5899 None -63.84, 141.4 -115.91, 33.22 -83.51, 160.0 53.06, 70.48 67.02, 7.94 in-in in 7.991 Saltbr-in 2.943 HRD-in -97.28, -53.9 73.81, -6.95 in-out-in SNCioi out-in ActLoopNT-out 5.553 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.01, 127.73 APE9-dihe-in -117.46, 161.57 APE8-dihe-in -80.14, 92.99 APE8-rot-na 30.73 APE67-dihe-in -63.44, -19.12 -41.75, -48.48 APE12-dist-na 19.4824 APE11-dist-na 14.7574 APE10-dist-na 17.4356 APE9-dist-in 7.1251 K12R,D363N None None XRAY 3.42 0.306 0.315 B 537.0 365.0 0 29 29 0 [[242, 495]] 1.0 1opl Homo sapiens TYR_ABL1_HUMAN TYR 6.7e-99 336.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 5MO4A P00519 64 512 1130.0 NIL:60601,AY7:60602 Type2,Allosteric Inactive DFGout 13.9474 11.3183 None -138.43, -177.76 -149.4, 98.71 -92.55, 999.0 320.75, 134.82 999.0, 999.0 in-in in 8.1062 Saltbr-in 2.797 HRD-in -66.66, -50.58 73.57, -12.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -49.47 APE8-dihe-out -61.4, -6.43 APE8-rot-na 335.89 APE67-dihe-in -62.17, -20.21 -56.07, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.0984 None None None XRAY 2.17 0.184 0.217 A 495.0 429.0 20 29 11 18 [[242, 495]] 1.0 5mo4 Homo sapiens TYR_ABL1_HUMAN TYR 1.1e-98 336.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_HUMAN 4WA9A P00519 246 504 1130.0 AXI:69000 Type1 Inactive None 999.0 10.3553 None -73.83, 149.34 -77.87, -21.14 -66.14, 121.84 190.75, 64.67 115.23, -11.12 none-none none 999.0 Saltbr-none 999.0 HRD-out -124.23, 124.72 -84.31, -3.72 none-out-in SNCnoi out-in ActLoopNT-out 5.4093 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.89, 135.91 APE9-dihe-in -108.88, 156.35 APE8-dihe-in -71.91, 93.83 APE8-rot-na 24.22 APE67-dihe-in -74.38, -8.52 -49.97, -43.55 APE12-dist-na 18.5615 APE11-dist-na 13.7767 APE10-dist-na 16.6613 APE9-dist-in 6.4914 None None None XRAY 2.2 0.175 0.212 A 286.0 236.0 23 29 29 0 [[242, 495]] 1.0 4wa9 Homo sapiens TYR_ABL1_HUMAN TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 2Z60A P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.8489 13.4808 BLAminus -137.02, -172.04 59.64, 81.83 -96.6, 21.67 303.76, 107.0 -57.3, -29.84 in-in in 7.7091 Saltbr-in 2.6409 HRD-in -89.4, -48.82 73.73, 3.17 in-in-in SNCiii in-in ActLoopNT-in 2.8401 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.81, 154.38 APE9-dihe-in -134.15, 168.28 APE8-dihe-in -62.25, 96.21 APE8-rot-na 339.53 APE67-dihe-in -71.21, -15.43 -42.73, -46.48 APE12-dist-na 15.5642 APE11-dist-na 10.7289 APE10-dist-na 13.4209 APE9-dist-in 7.2625 T315I None None XRAY 1.95 0.206 0.245 A 288.0 280.0 3 29 29 0 [[242, 495]] 1.0 2z60 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 2QOHA P00520 229 501 1123.0 P3Y:60001 Type1 Active DFGin 6.7921 13.2995 BLAminus -137.18, -173.6 58.31, 89.23 -103.73, 22.71 305.14, 99.76 -56.65, -30.84 in-in in 7.8327 Saltbr-in 2.6477 HRD-in -86.16, -51.73 78.16, -1.08 in-in-in SNCiii in-in ActLoopNT-in 3.171 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.12, 148.82 APE9-dihe-in -123.25, 167.08 APE8-dihe-in -79.06, 86.62 APE8-rot-na 341.05 APE67-dihe-in -62.47, -15.79 -35.13, -54.47 APE12-dist-na 15.2292 APE11-dist-na 10.5455 APE10-dist-na 13.1827 APE9-dist-in 7.3193 None None None XRAY 1.95 0.214 0.255 A 288.0 270.0 3 29 29 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 2QOHB P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.9544 13.0302 BLAminus -146.85, -174.9 61.51, 81.39 -99.78, 25.49 304.24, 93.09 -56.89, -22.43 in-in in 7.8826 Saltbr-in 2.7208 HRD-in -91.49, -48.67 74.38, 6.2 in-in-in SNCiii in-in ActLoopNT-in 2.9879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.22, 145.99 APE9-dihe-in -127.49, 165.6 APE8-dihe-in -83.22, 84.35 APE8-rot-na 349.39 APE67-dihe-in -72.21, -14.36 -35.43, -45.09 APE12-dist-na 15.2466 APE11-dist-na 10.5053 APE10-dist-na 12.8375 APE9-dist-in 7.3997 None None None XRAY 1.95 0.214 0.255 B 288.0 280.0 3 29 29 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KF4A P00520 229 514 1123.0 B90:1 Type1.5_Back Active DFGin 6.7169 13.4873 BLAminus -138.47, -169.78 64.32, 74.67 -103.01, 17.52 308.56, 103.02 -57.24, -29.09 in-in in 8.0382 Saltbr-in 2.8417 HRD-in -97.68, -52.38 80.64, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.8342 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 154.17 APE9-dihe-in -130.7, 158.73 APE8-dihe-in -75.38, 102.27 APE8-rot-na 27.21 APE67-dihe-in -74.45, -9.72 -55.5, -39.82 APE12-dist-na 14.4827 APE11-dist-na 10.0633 APE10-dist-na 13.048 APE9-dist-in 7.3155 None None None XRAY 1.9 0.197 0.24 A 288.0 281.0 5 29 29 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KF4B P00520 229 501 1123.0 B90:1 Type1.5_Back Active DFGin 6.6728 13.6493 BLAminus -131.98, -172.92 66.04, 78.12 -105.54, 16.69 306.01, 100.01 -53.92, -33.68 in-in in 8.0989 Saltbr-in 2.8705 HRD-in -96.09, -52.11 78.87, 6.97 in-in-in SNCiii in-in ActLoopNT-in 2.9374 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.63, 136.23 APE9-dihe-in -115.19, 156.97 APE8-dihe-in -69.24, 107.22 APE8-rot-na 26.84 APE67-dihe-in -70.3, -19.91 -54.93, -42.84 APE12-dist-na 15.1548 APE11-dist-na 10.3964 APE10-dist-na 13.2058 APE9-dist-in 7.4693 None None None XRAY 1.9 0.197 0.24 B 288.0 270.0 3 29 29 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK7A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.5206 4.4696 None -65.94, 133.62 -136.37, 26.36 -59.29, -46.94 277.65, 138.09 -96.98, 21.57 in-in in 7.7662 Saltbr-in 2.7931 HRD-in -90.33, -58.06 79.79, -1.99 in-out-in SNCioi out-in ActLoopNT-out 5.6754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.5, 130.75 APE9-dihe-in -114.11, 153.09 APE8-dihe-in -69.74, 90.62 APE8-rot-na 25.02 APE67-dihe-in -72.01, -11.59 -51.31, -42.54 APE12-dist-na 20.5794 APE11-dist-na 15.9289 APE10-dist-na 18.2248 APE9-dist-in 7.4473 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 A 277.0 266.0 4 29 29 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK6A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.8348 8.3063 None -61.57, 128.5 -127.52, 27.29 -83.26, -21.75 331.68, 119.16 -112.49, 27.73 in-in in 7.9744 Saltbr-in 2.8932 HRD-in -91.42, -55.08 73.35, 1.27 in-out-in SNCioi out-in ActLoopNT-out 5.6596 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.77, 134.59 APE9-dihe-in -117.57, 154.09 APE8-dihe-in -69.69, 91.12 APE8-rot-na 24.6 APE67-dihe-in -73.26, -8.23 -48.64, -44.69 APE12-dist-na 20.5253 APE11-dist-na 15.9405 APE10-dist-na 18.1706 APE9-dist-in 7.3899 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 A 293.0 263.0 7 29 29 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK6B P00520 234 505 1123.0 SX7:2 Type1 Inactive DFGinter 9.6071 8.2114 None -63.13, 129.74 -127.1, 39.65 -91.94, -7.89 322.45, 123.44 -137.52, 35.5 in-none in 8.4774 Saltbr-none 999.0 HRD-in -90.89, -55.29 76.04, -7.16 none-out-in SNCnoi out-in ActLoopNT-out 5.5801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.73, 139.41 APE9-dihe-in -127.03, 148.23 APE8-dihe-in -65.18, 97.87 APE8-rot-na 342.63 APE67-dihe-in -74.45, -10.42 -49.61, -43.27 APE12-dist-na 18.8406 APE11-dist-na 14.1844 APE10-dist-na 17.3008 APE9-dist-in 6.943 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 B 293.0 260.0 12 29 29 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK3A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.0367 4.5337 None -66.29, 133.89 -136.12, 20.26 -58.29, -43.12 280.16, 137.15 -98.94, 20.71 in-in in 7.6282 Saltbr-in 2.858 HRD-in -87.93, -54.51 76.79, -4.02 in-out-in SNCioi out-in ActLoopNT-out 5.6813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.14, 131.04 APE9-dihe-in -114.33, 156.79 APE8-dihe-in -71.32, 89.5 APE8-rot-na 25.37 APE67-dihe-in -70.0, -11.6 -49.65, -44.27 APE12-dist-na 20.741 APE11-dist-na 16.0089 APE10-dist-na 18.2899 APE9-dist-in 7.2767 Y393F,L445P None None XRAY 2.02 0.213 0.248 A 293.0 266.0 4 29 29 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK3B P00520 233 505 1123.0 SX7:2 Type1 Inactive DFGinter 8.6536 4.7617 None -66.35, 137.23 -141.11, 32.97 -68.57, -40.89 274.02, 151.63 -104.05, 31.43 in-in in 7.7258 Saltbr-in 2.7276 HRD-in -97.18, -55.69 76.9, -3.17 in-out-in SNCioi out-in ActLoopNT-out 5.5537 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.31, 136.08 APE9-dihe-in -118.61, 148.91 APE8-dihe-in -68.85, 95.72 APE8-rot-na 24.23 APE67-dihe-in -70.92, -12.54 -48.57, -45.29 APE12-dist-na 19.2122 APE11-dist-na 14.5504 APE10-dist-na 17.6214 APE9-dist-in 7.0018 Y393F,L445P None None XRAY 2.02 0.213 0.248 B 293.0 269.0 4 29 29 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3K5VA P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.8272 11.0249 BBAminus -129.03, -178.81 -148.62, 103.08 -90.49, -4.28 302.25, 133.06 63.11, 53.01 in-in in 8.2222 Saltbr-in 2.8352 HRD-in -81.75, -55.21 87.7, -18.23 in-out-in SNCioi out-in ActLoopNT-out 16.3689 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.52, 121.82 APE9-dihe-in -113.18, 143.79 APE8-dihe-in -83.6, 88.45 APE8-rot-na 28.73 APE67-dihe-in -74.9, -7.51 -50.51, -43.0 APE12-dist-na 15.7887 APE11-dist-na 11.6924 APE10-dist-na 8.4451 APE9-dist-in 7.7803 None None None XRAY 1.74 0.201 0.231 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3K5VB P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.7649 11.0764 BBAminus -130.59, 178.94 -144.92, 105.3 -91.47, 1.18 305.46, 130.21 51.7, 50.11 in-in in 8.2219 Saltbr-in 2.8668 HRD-in -85.29, -53.14 86.12, -16.51 in-out-in SNCioi out-in ActLoopNT-out 16.4024 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.28, 125.5 APE9-dihe-in -111.48, 141.99 APE8-dihe-in -82.96, 81.2 APE8-rot-na 29.67 APE67-dihe-in -69.06, -10.18 -42.49, -48.14 APE12-dist-na 15.5836 APE11-dist-na 11.5044 APE10-dist-na 8.5983 APE9-dist-in 7.7555 None None None XRAY 1.74 0.201 0.231 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD4A P00520 229 510 1123.0 FYW:60603,STI:60604 Allosteric,Type2 Inactive DFGout 13.7764 10.9351 BBAminus -130.79, -174.69 -153.04, 100.11 -89.33, 0.88 308.19, 134.35 53.16, 51.61 in-in in 8.1144 Saltbr-in 2.8706 HRD-in -79.72, -53.57 88.06, -19.16 in-out-in SNCioi out-in ActLoopNT-out 16.4097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.86, 116.72 APE9-dihe-in -109.35, 142.84 APE8-dihe-in -86.21, 87.25 APE8-rot-na 23.52 APE67-dihe-in -69.15, -11.0 -46.61, -47.58 APE12-dist-na 15.7751 APE11-dist-na 11.7898 APE10-dist-na 8.3351 APE9-dist-in 7.8592 None None None XRAY 2.03 0.183 0.223 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD4B P00520 229 510 1123.0 FYW:60601,STI:60602 Allosteric,Type2 Inactive DFGout 13.8473 11.0365 BBAminus -132.33, -177.63 -150.45, 101.55 -90.95, -0.99 307.99, 135.01 52.91, 55.37 in-in in 8.1545 Saltbr-in 2.9282 HRD-in -79.19, -55.7 86.14, -16.91 in-out-in SNCioi out-in ActLoopNT-out 16.5243 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.49, 127.44 APE9-dihe-in -117.65, 140.28 APE8-dihe-in -83.09, 79.07 APE8-rot-na 27.61 APE67-dihe-in -65.5, -15.42 -38.27, -50.77 APE12-dist-na 15.5651 APE11-dist-na 11.2452 APE10-dist-na 8.3706 APE9-dist-in 7.8777 None None None XRAY 2.03 0.183 0.223 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD6A P00520 229 510 1123.0 FYH:60602,STI:60603 Allosteric,Type2 Inactive DFGout 13.7876 10.8987 BBAminus -118.54, -176.91 -146.68, 104.9 -90.05, -6.03 304.11, 138.72 66.96, 55.15 in-in in 8.2952 Saltbr-in 2.8153 HRD-in -88.34, -54.67 91.97, -25.73 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.42, 121.54 APE9-dihe-in -110.97, 144.39 APE8-dihe-in -82.04, 86.81 APE8-rot-na 32.54 APE67-dihe-in -76.73, -9.19 -49.14, -40.38 APE12-dist-na 15.6429 APE11-dist-na 11.6814 APE10-dist-na 8.157 APE9-dist-in 7.7625 None None None XRAY 2.3 0.178 0.238 A 293.0 280.0 2 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3OY3A P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 12.9466 9.007 BBAminus -137.29, -169.78 -157.65, 128.99 -111.75, 11.85 289.0, 94.91 50.98, 52.65 in-in in 7.8674 Saltbr-in 2.9891 HRD-in -74.78, -52.15 78.88, -9.23 in-out-in SNCioi out-in ActLoopNT-out 15.5658 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.56, 121.47 APE9-dihe-in -112.4, 142.91 APE8-dihe-in -82.9, 85.53 APE8-rot-na 34.55 APE67-dihe-in -73.05, -8.51 -46.67, -46.08 APE12-dist-na 15.6711 APE11-dist-na 11.5488 APE10-dist-na 8.3152 APE9-dist-in 7.9262 T315I None None XRAY 1.95 0.22 0.266 A 284.0 283.0 0 29 29 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3OY3B P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 13.0435 8.8062 BBAminus -137.08, -175.15 -152.62, 125.15 -107.82, 7.08 288.46, 102.59 51.48, 58.3 in-in in 7.8642 Saltbr-in 2.4712 HRD-in -70.89, -52.75 81.95, -16.85 in-out-in SNCioi out-in ActLoopNT-out 15.7399 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.39, 125.75 APE9-dihe-in -114.93, 142.91 APE8-dihe-in -80.63, 91.02 APE8-rot-na 31.59 APE67-dihe-in -73.68, -7.56 -52.87, -45.41 APE12-dist-na 15.7295 APE11-dist-na 11.5248 APE10-dist-na 8.2656 APE9-dist-in 7.9883 T315I None None XRAY 1.95 0.22 0.266 B 284.0 283.0 0 29 29 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.5039 9.4383 BBAminus -139.29, -179.88 -153.49, 108.65 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.5375 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.0102 APE11-dist-na 11.8397 APE10-dist-na 8.4563 APE9-dist-in 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288.0 279.0 6 29 23 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.4975 9.1697 BBAminus -129.46, 178.53 -148.47, 114.27 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.9919 Saltbr-in 2.6552 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.7027 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.8259 APE11-dist-na 11.5962 APE10-dist-na 8.603 APE9-dist-in 7.8512 T315I None None XRAY 1.9 0.216 0.258 B 288.0 285.0 0 29 29 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.3158 8.9403 BBAminus -130.11, -171.24 -154.37, 127.79 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.0038 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.3775 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-out 8.088 None None None XRAY 2.2 0.218 0.261 A 284.0 267.0 16 29 19 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KFAA P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.2442 8.8197 BBAminus -142.27, -176.56 -152.63, 125.74 -107.34, 5.74 288.91, 88.99 58.04, 50.09 in-in in 8.1404 Saltbr-in 2.7169 HRD-in -73.85, -48.11 82.13, -13.17 in-out-in SNCioi out-in ActLoopNT-out 15.6397 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.63, 125.03 APE9-dihe-in -114.41, 145.91 APE8-dihe-in -84.21, 85.96 APE8-rot-na 33.66 APE67-dihe-in -73.3, -8.53 -52.44, -41.01 APE12-dist-na 15.8025 APE11-dist-na 11.654 APE10-dist-na 8.6661 APE9-dist-in 7.7127 None None None XRAY 1.22 0.201 0.201 A 288.0 283.0 0 29 29 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KFAB P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.2546 8.8052 BBAminus -140.52, -176.97 -152.37, 125.18 -106.35, 4.72 288.28, 89.94 58.68, 49.29 in-in in 8.1374 Saltbr-in 2.6923 HRD-in -74.33, -47.79 81.87, -12.97 in-out-in SNCioi out-in ActLoopNT-out 15.6035 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.66, 126.45 APE9-dihe-in -115.84, 145.74 APE8-dihe-in -82.6, 85.95 APE8-rot-na 33.9 APE67-dihe-in -74.2, -7.78 -53.04, -40.32 APE12-dist-na 15.7892 APE11-dist-na 11.659 APE10-dist-na 8.7035 APE9-dist-in 7.698 None None None XRAY 1.22 0.201 0.201 B 288.0 283.0 0 29 29 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1FPUA P00520 229 499 1123.0 PRC:60001 Type2 Inactive DFGout 13.4179 10.9488 BBAminus -141.9, -166.28 -158.13, 103.8 -90.94, 3.8 310.97, 131.54 54.26, 50.94 in-in in 8.4034 Saltbr-in 2.871 HRD-in -86.77, -50.24 77.96, -12.71 in-out-in SNCioi out-in ActLoopNT-out 16.2249 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.73, 138.95 APE9-dihe-in -131.33, 134.86 APE8-dihe-in -81.8, 82.67 APE8-rot-na 35.36 APE67-dihe-in -73.73, -7.55 -41.73, -44.76 APE12-dist-na 14.1131 APE11-dist-na 12.2538 APE10-dist-na 8.1396 APE9-dist-in 7.4423 None None None XRAY 2.4 0.239 0.264 A 293.0 271.0 0 29 29 0 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1FPUB P00520 229 499 1123.0 PRC:60002 Type2 Inactive DFGout 13.5087 10.529 BBAminus -141.62, -165.58 -158.88, 104.33 -91.66, 4.75 310.99, 131.8 53.0, 51.49 in-in in 8.316 Saltbr-in 3.0589 HRD-in -85.61, -50.1 76.84, -10.82 in-out-in SNCioi out-in ActLoopNT-out 16.231 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.53, 139.19 APE9-dihe-in -131.35, 134.07 APE8-dihe-in -80.76, 81.97 APE8-rot-na 34.87 APE67-dihe-in -70.5, -12.0 -41.07, -44.99 APE12-dist-na 14.1073 APE11-dist-na 12.255 APE10-dist-na 8.1365 APE9-dist-in 7.4503 None None None XRAY 2.4 0.239 0.264 B 293.0 266.0 5 29 24 5 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1IEPA P00520 229 498 1123.0 STI:60201 Type2 Inactive DFGout 13.5616 10.8609 BBAminus -137.03, -172.54 -153.96, 97.64 -87.18, 3.68 308.79, 136.8 52.65, 57.65 in-in in 8.3113 Saltbr-in 3.1021 HRD-in -76.11, -58.44 87.76, -16.49 in-out-in SNCioi out-in ActLoopNT-out 16.3209 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.61, 141.98 APE9-dihe-in -135.62, 143.41 APE8-dihe-in -82.32, 86.58 APE8-rot-na 35.1 APE67-dihe-in -73.95, -4.51 -43.85, -43.13 APE12-dist-na 14.642 APE11-dist-na 11.7988 APE10-dist-na 8.4893 APE9-dist-in 7.3405 None None None XRAY 2.1 0.231 0.262 A 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1IEPB P00520 229 498 1123.0 STI:60202 Type2 Inactive DFGout 13.5287 10.801 BBAminus -143.94, -178.65 -148.11, 93.74 -82.6, -2.47 307.48, 137.57 62.07, 48.88 in-out in 8.1853 Saltbr-out 4.3676 HRD-in -84.56, -56.22 87.89, -19.72 out-out-in SNCooi out-in ActLoopNT-out 14.9721 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.54, 140.59 APE9-dihe-in -139.53, 149.49 APE8-dihe-in -85.03, 86.81 APE8-rot-na 36.13 APE67-dihe-in -68.22, -7.81 -42.13, -46.9 APE12-dist-na 15.6933 APE11-dist-na 11.543 APE10-dist-na 8.6711 APE9-dist-in 7.1993 None None None XRAY 2.1 0.231 0.262 B 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1OPJA P00520 229 510 1123.0 STI:60003 Type2 Inactive DFGout 13.7798 10.8261 BBAminus -128.07, -174.54 -152.92, 98.6 -89.13, 6.29 307.36, 137.21 49.4, 56.53 in-in in 8.2618 Saltbr-in 2.6832 HRD-in -85.47, -54.47 85.47, -15.74 in-out-out SNCioo out-out ActLoopNT-out 16.1376 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -110.59, 111.76 APE9-dihe-in -105.57, 139.7 APE8-dihe-in -87.32, 84.08 APE8-rot-na 31.83 APE67-dihe-in -67.58, -10.57 -46.59, -43.84 APE12-dist-na 15.8128 APE11-dist-na 11.6321 APE10-dist-na 8.4599 APE9-dist-out 8.0909 None None None XRAY 1.75 0.21 0.242 A 293.0 282.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1OPJB P00520 229 512 1123.0 STI:60004 Type2 Inactive DFGout 13.9109 11.3214 BBAminus -132.18, -179.0 -150.37, 98.45 -86.36, 2.32 310.86, 130.49 52.69, 56.75 in-in in 8.0553 Saltbr-in 2.8815 HRD-in -79.51, -55.82 87.48, -17.62 in-out-in SNCioi out-in ActLoopNT-out 16.1636 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.86, 121.43 APE9-dihe-in -116.41, 142.51 APE8-dihe-in -88.15, 80.96 APE8-rot-na 32.33 APE67-dihe-in -69.25, -7.13 -40.7, -49.19 APE12-dist-na 15.7903 APE11-dist-na 11.8331 APE10-dist-na 8.395 APE9-dist-in 7.8063 None None None XRAY 1.75 0.21 0.242 B 293.0 284.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 2HZNA P00520 229 502 1123.0 KIN:60600 Type2 Inactive DFGout 14.958 9.6719 BBAminus -139.88, -164.81 -155.74, 124.37 -98.42, -30.89 272.45, 94.35 80.92, 43.41 in-in in 8.1612 Saltbr-in 2.5756 HRD-in -62.12, -53.83 87.41, -26.87 in-out-in SNCioi out-in ActLoopNT-out 16.1634 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.47, 150.88 APE9-dihe-in -140.18, 135.21 APE8-dihe-in -65.94, 87.96 APE8-rot-na 341.9 APE67-dihe-in -68.13, -18.79 -49.49, -50.03 APE12-dist-na 15.039 APE11-dist-na 10.6139 APE10-dist-na 8.5822 APE9-dist-in 7.3169 None None None XRAY 2.7 0.267 0.314 A 293.0 269.0 5 29 29 0 [[242, 495]] 1.0 2hzn Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD6B P00520 229 510 1123.0 STI:60601 Type2 Inactive DFGout 13.8292 11.1791 BBAminus -125.12, -175.5 -154.19, 103.09 -91.96, 21.1 310.97, 128.7 31.22, 64.2 in-in in 8.3943 Saltbr-in 3.0721 HRD-in -85.22, -51.46 85.37, -17.4 in-out-in SNCioi out-in ActLoopNT-out 16.3685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.94, 122.32 APE9-dihe-in -101.91, 149.19 APE8-dihe-in -81.38, 82.15 APE8-rot-na 19.67 APE67-dihe-in -78.93, -7.66 -49.97, -39.1 APE12-dist-na 15.412 APE11-dist-na 11.1785 APE10-dist-na 8.7641 APE9-dist-in 7.7824 None None None XRAY 2.3 0.178 0.238 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MS9A P00520 230 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6604 10.9917 BBAminus -129.69, -177.84 -146.05, 100.92 -85.37, -0.41 305.07, 135.33 63.76, 47.34 in-in in 8.3409 Saltbr-in 3.1533 HRD-in -79.52, -52.27 83.07, -15.37 in-out-in SNCioi out-in ActLoopNT-out 16.086 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.38, 129.78 APE9-dihe-in -118.07, 145.91 APE8-dihe-in -88.08, 91.81 APE8-rot-na 29.01 APE67-dihe-in -75.19, -6.62 -50.02, -40.18 APE12-dist-na 14.3629 APE11-dist-na 12.2197 APE10-dist-na 8.6387 APE9-dist-in 7.5316 None None None XRAY 1.8 0.188 0.234 A 293.0 261.0 8 29 27 2 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MS9B P00520 229 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6482 10.9444 BBAminus -132.64, -179.46 -143.9, 102.88 -90.37, 5.1 303.67, 135.83 60.73, 51.4 in-in in 8.2919 Saltbr-in 2.7815 HRD-in -83.7, -52.15 86.58, -11.15 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.02, 135.09 APE9-dihe-in -128.33, 142.16 APE8-dihe-in -86.14, 87.78 APE8-rot-na 36.31 APE67-dihe-in -76.28, -2.93 -48.89, -43.33 APE12-dist-na 15.5909 APE11-dist-na 13.452 APE10-dist-na 8.8559 APE9-dist-in 7.6276 None None None XRAY 1.8 0.188 0.234 B 293.0 267.0 3 29 29 0 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSA P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.6024 10.9266 BBAminus -140.22, -178.36 -147.69, 104.27 -89.71, -2.47 299.0, 139.73 66.29, 43.35 in-in in 8.3889 Saltbr-in 3.0948 HRD-in -74.19, -56.0 83.94, -13.58 in-out-in SNCioi out-in ActLoopNT-out 16.2188 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.21, 134.82 APE9-dihe-in -123.76, 144.56 APE8-dihe-in -89.25, 91.24 APE8-rot-na 26.73 APE67-dihe-in -76.81, -6.98 -52.23, -37.7 APE12-dist-na 14.4457 APE11-dist-na 11.9742 APE10-dist-na 8.5807 APE9-dist-in 7.4405 None None None XRAY 1.95 0.172 0.22 A 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSB P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5999 10.8202 BBAminus -134.26, 179.26 -142.74, 100.94 -88.95, 3.79 301.55, 135.44 59.27, 50.16 in-in in 8.1878 Saltbr-in 2.7291 HRD-in -84.32, -52.44 85.34, -18.42 in-out-in SNCioi out-in ActLoopNT-out 15.3256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.6, 137.91 APE9-dihe-in -132.77, 140.13 APE8-dihe-in -80.01, 89.25 APE8-rot-na 23.44 APE67-dihe-in -77.65, -10.14 -50.83, -40.78 APE12-dist-na 15.5761 APE11-dist-na 13.4863 APE10-dist-na 8.8 APE9-dist-in 7.4545 None None None XRAY 1.95 0.172 0.22 B 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSC P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5909 10.9626 BBAminus -138.8, 179.7 -144.18, 103.21 -86.54, 1.5 302.89, 134.71 58.1, 46.5 in-in in 8.0875 Saltbr-in 3.0475 HRD-in -78.89, -57.09 86.43, -17.08 in-out-in SNCioi out-in ActLoopNT-out 16.1082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.32, 131.91 APE9-dihe-in -126.48, 145.59 APE8-dihe-in -89.99, 90.94 APE8-rot-na 26.3 APE67-dihe-in -77.37, -6.31 -51.14, -38.56 APE12-dist-na 14.5938 APE11-dist-na 11.8497 APE10-dist-na 8.4632 APE9-dist-in 7.442 None None None XRAY 1.95 0.172 0.22 C 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSD P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5469 10.7877 BBAminus -134.13, -175.99 -148.24, 101.28 -89.17, 5.19 302.32, 137.83 56.24, 49.56 in-in in 8.1921 Saltbr-in 2.7895 HRD-in -83.98, -55.12 89.03, -15.39 in-out-in SNCioi out-in ActLoopNT-out 15.5394 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.05, 133.37 APE9-dihe-in -131.92, 141.87 APE8-dihe-in -80.66, 89.72 APE8-rot-na 31.84 APE67-dihe-in -74.69, -8.69 -52.73, -42.14 APE12-dist-na 15.622 APE11-dist-na 13.6062 APE10-dist-na 8.7829 APE9-dist-in 7.554 None None None XRAY 1.95 0.172 0.22 D 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1M52A P00520 232 502 1123.0 P17:119 Type1.5_Back Inactive DFGout 12.7932 10.7534 None -60.22, 138.56 -89.44, -13.76 -71.29, 150.54 62.03, 63.6 85.22, 23.45 in-in in 7.8946 Saltbr-in 2.7072 HRD-out -103.5, 129.11 -84.41, -9.26 in-out-in SNCioi out-in ActLoopNT-out 5.5228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.32, 126.97 APE9-dihe-in -125.58, 158.53 APE8-dihe-in -60.22, 106.23 APE8-rot-na 28.98 APE67-dihe-in -61.13, -15.48 -48.91, -53.77 APE12-dist-na 18.5358 APE11-dist-na 14.0518 APE10-dist-na 17.1001 APE9-dist-in 6.3399 None None None XRAY 2.6 0.211 0.254 A 293.0 271.0 0 29 29 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1M52B P00520 232 503 1123.0 P17:120 Type1.5_Back Inactive DFGout 12.7809 10.9966 None -67.54, 135.07 -84.58, -12.33 -70.24, 151.37 63.17, 66.62 85.76, 18.68 in-in in 8.0957 Saltbr-in 2.8231 HRD-out -106.35, 123.08 -78.82, -9.36 in-out-in SNCioi out-in ActLoopNT-out 5.5791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.32, 130.43 APE9-dihe-in -127.38, 164.85 APE8-dihe-in -67.06, 104.95 APE8-rot-na 28.73 APE67-dihe-in -58.93, -14.72 -46.9, -55.31 APE12-dist-na 18.9417 APE11-dist-na 14.1825 APE10-dist-na 17.0323 APE9-dist-in 6.3696 None None None XRAY 2.6 0.211 0.254 B 293.0 272.0 0 29 29 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1OPKA P00520 64 512 1123.0 P16:60002 Type1.5_Back Inactive DFGout 12.8526 11.5242 None -65.37, 134.02 -116.02, 33.5 -83.75, 159.92 53.06, 70.43 67.02, 7.91 in-in in 7.9566 Saltbr-in 2.9399 HRD-in -97.25, -54.03 73.87, -6.88 in-out-in SNCioi out-in ActLoopNT-out 5.5583 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.1, 127.8 APE9-dihe-in -117.64, 161.56 APE8-dihe-in -80.21, 93.15 APE8-rot-na 30.65 APE67-dihe-in -63.48, -19.22 -41.98, -48.41 APE12-dist-na 19.4802 APE11-dist-na 14.7534 APE10-dist-na 17.431 APE9-dist-in 7.1248 D363N None None XRAY 1.8 0.196 0.221 A 495.0 449.0 0 29 29 0 [[242, 495]] 1.0 1opk Mus musculus TYR_ABL1_MOUSE TYR 5.5e-99 337.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK7B P00520 233 505 1123.0 SX7:2 Type1 Inactive None 999.0 999.0 None -70.09, 131.91 -99.1, 30.92 -47.67, -78.64 999.0, 999.0 -116.53, 59.69 in-none in 8.1534 Saltbr-none 999.0 HRD-in -96.35, -57.33 75.78, -1.22 none-out-in SNCnoi out-in ActLoopNT-out 5.6353 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.0, 138.44 APE9-dihe-in -123.96, 150.21 APE8-dihe-in -64.33, 99.33 APE8-rot-na 21.28 APE67-dihe-in -72.95, -10.57 -50.9, -44.43 APE12-dist-na 19.1355 APE11-dist-na 14.4826 APE10-dist-na 17.474 APE9-dist-in 7.0192 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 B 277.0 269.0 4 29 29 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1

TYR_ABL1 (Tyrosine-protein kinase ABL1)

Total number of chains: 40
Active chains: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGout BBAminus 26 65.0% 3KFAA
DFGin BLAminus 5 12.5% 3KF4B
DFGinter None 5 12.5% 3DK7A
DFGout None 3 7.5% 1OPKA
None None 1 2.5% 3DK7B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
ABL1 ABL1_MOUSE 2Z60A P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.8489 13.4808 BLAminus -137.02, -172.04 59.64, 81.83 -96.6, 21.67 303.76, 107.0 -57.3, -29.84 in-in in 7.7091 Saltbr-in 2.6409 HRD-in -89.4, -48.82 73.73, 3.17 in-in-in SNCiii in-in ActLoopNT-in 2.8401 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.81, 154.38 APE9-dihe-in -134.15, 168.28 APE8-dihe-in -62.25, 96.21 APE8-rot-na 339.53 APE67-dihe-in -71.21, -15.43 -42.73, -46.48 APE12-dist-na 15.5642 APE11-dist-na 10.7289 APE10-dist-na 13.4209 APE9-dist-in 7.2625 T315I None None XRAY 1.95 0.206 0.245 A 288.0 280.0 3 29 29 0 [[242, 495]] 1.0 2z60 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 2QOHA P00520 229 501 1123.0 P3Y:60001 Type1 Active DFGin 6.7921 13.2995 BLAminus -137.18, -173.6 58.31, 89.23 -103.73, 22.71 305.14, 99.76 -56.65, -30.84 in-in in 7.8327 Saltbr-in 2.6477 HRD-in -86.16, -51.73 78.16, -1.08 in-in-in SNCiii in-in ActLoopNT-in 3.171 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.12, 148.82 APE9-dihe-in -123.25, 167.08 APE8-dihe-in -79.06, 86.62 APE8-rot-na 341.05 APE67-dihe-in -62.47, -15.79 -35.13, -54.47 APE12-dist-na 15.2292 APE11-dist-na 10.5455 APE10-dist-na 13.1827 APE9-dist-in 7.3193 None None None XRAY 1.95 0.214 0.255 A 288.0 270.0 3 29 29 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 2QOHB P00520 229 511 1123.0 P3Y:60001 Type1 Active DFGin 6.9544 13.0302 BLAminus -146.85, -174.9 61.51, 81.39 -99.78, 25.49 304.24, 93.09 -56.89, -22.43 in-in in 7.8826 Saltbr-in 2.7208 HRD-in -91.49, -48.67 74.38, 6.2 in-in-in SNCiii in-in ActLoopNT-in 2.9879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.22, 145.99 APE9-dihe-in -127.49, 165.6 APE8-dihe-in -83.22, 84.35 APE8-rot-na 349.39 APE67-dihe-in -72.21, -14.36 -35.43, -45.09 APE12-dist-na 15.2466 APE11-dist-na 10.5053 APE10-dist-na 12.8375 APE9-dist-in 7.3997 None None None XRAY 1.95 0.214 0.255 B 288.0 280.0 3 29 29 0 [[242, 495]] 1.0 2qoh Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KF4A P00520 229 514 1123.0 B90:1 Type1.5_Back Active DFGin 6.7169 13.4873 BLAminus -138.47, -169.78 64.32, 74.67 -103.01, 17.52 308.56, 103.02 -57.24, -29.09 in-in in 8.0382 Saltbr-in 2.8417 HRD-in -97.68, -52.38 80.64, 2.77 in-in-in SNCiii in-in ActLoopNT-in 2.8342 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.08, 154.17 APE9-dihe-in -130.7, 158.73 APE8-dihe-in -75.38, 102.27 APE8-rot-na 27.21 APE67-dihe-in -74.45, -9.72 -55.5, -39.82 APE12-dist-na 14.4827 APE11-dist-na 10.0633 APE10-dist-na 13.048 APE9-dist-in 7.3155 None None None XRAY 1.9 0.197 0.24 A 288.0 281.0 5 29 29 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KF4B P00520 229 501 1123.0 B90:1 Type1.5_Back Active DFGin 6.6728 13.6493 BLAminus -131.98, -172.92 66.04, 78.12 -105.54, 16.69 306.01, 100.01 -53.92, -33.68 in-in in 8.0989 Saltbr-in 2.8705 HRD-in -96.09, -52.11 78.87, 6.97 in-in-in SNCiii in-in ActLoopNT-in 2.9374 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -96.63, 136.23 APE9-dihe-in -115.19, 156.97 APE8-dihe-in -69.24, 107.22 APE8-rot-na 26.84 APE67-dihe-in -70.3, -19.91 -54.93, -42.84 APE12-dist-na 15.1548 APE11-dist-na 10.3964 APE10-dist-na 13.2058 APE9-dist-in 7.4693 None None None XRAY 1.9 0.197 0.24 B 288.0 270.0 3 29 29 0 [[242, 495]] 1.0 3kf4 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK7A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.5206 4.4696 None -65.94, 133.62 -136.37, 26.36 -59.29, -46.94 277.65, 138.09 -96.98, 21.57 in-in in 7.7662 Saltbr-in 2.7931 HRD-in -90.33, -58.06 79.79, -1.99 in-out-in SNCioi out-in ActLoopNT-out 5.6754 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -107.5, 130.75 APE9-dihe-in -114.11, 153.09 APE8-dihe-in -69.74, 90.62 APE8-rot-na 25.02 APE67-dihe-in -72.01, -11.59 -51.31, -42.54 APE12-dist-na 20.5794 APE11-dist-na 15.9289 APE10-dist-na 18.2248 APE9-dist-in 7.4473 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 A 277.0 266.0 4 29 29 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK6A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.8348 8.3063 None -61.57, 128.5 -127.52, 27.29 -83.26, -21.75 331.68, 119.16 -112.49, 27.73 in-in in 7.9744 Saltbr-in 2.8932 HRD-in -91.42, -55.08 73.35, 1.27 in-out-in SNCioi out-in ActLoopNT-out 5.6596 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -110.77, 134.59 APE9-dihe-in -117.57, 154.09 APE8-dihe-in -69.69, 91.12 APE8-rot-na 24.6 APE67-dihe-in -73.26, -8.23 -48.64, -44.69 APE12-dist-na 20.5253 APE11-dist-na 15.9405 APE10-dist-na 18.1706 APE9-dist-in 7.3899 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 A 293.0 263.0 7 29 29 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK6B P00520 234 505 1123.0 SX7:2 Type1 Inactive DFGinter 9.6071 8.2114 None -63.13, 129.74 -127.1, 39.65 -91.94, -7.89 322.45, 123.44 -137.52, 35.5 in-none in 8.4774 Saltbr-none 999.0 HRD-in -90.89, -55.29 76.04, -7.16 none-out-in SNCnoi out-in ActLoopNT-out 5.5801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.73, 139.41 APE9-dihe-in -127.03, 148.23 APE8-dihe-in -65.18, 97.87 APE8-rot-na 342.63 APE67-dihe-in -74.45, -10.42 -49.61, -43.27 APE12-dist-na 18.8406 APE11-dist-na 14.1844 APE10-dist-na 17.3008 APE9-dist-in 6.943 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 B 293.0 260.0 12 29 29 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.2e-101 343.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK3A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.0367 4.5337 None -66.29, 133.89 -136.12, 20.26 -58.29, -43.12 280.16, 137.15 -98.94, 20.71 in-in in 7.6282 Saltbr-in 2.858 HRD-in -87.93, -54.51 76.79, -4.02 in-out-in SNCioi out-in ActLoopNT-out 5.6813 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -104.14, 131.04 APE9-dihe-in -114.33, 156.79 APE8-dihe-in -71.32, 89.5 APE8-rot-na 25.37 APE67-dihe-in -70.0, -11.6 -49.65, -44.27 APE12-dist-na 20.741 APE11-dist-na 16.0089 APE10-dist-na 18.2899 APE9-dist-in 7.2767 Y393F,L445P None None XRAY 2.02 0.213 0.248 A 293.0 266.0 4 29 29 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK3B P00520 233 505 1123.0 SX7:2 Type1 Inactive DFGinter 8.6536 4.7617 None -66.35, 137.23 -141.11, 32.97 -68.57, -40.89 274.02, 151.63 -104.05, 31.43 in-in in 7.7258 Saltbr-in 2.7276 HRD-in -97.18, -55.69 76.9, -3.17 in-out-in SNCioi out-in ActLoopNT-out 5.5537 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.31, 136.08 APE9-dihe-in -118.61, 148.91 APE8-dihe-in -68.85, 95.72 APE8-rot-na 24.23 APE67-dihe-in -70.92, -12.54 -48.57, -45.29 APE12-dist-na 19.2122 APE11-dist-na 14.5504 APE10-dist-na 17.6214 APE9-dist-in 7.0018 Y393F,L445P None None XRAY 2.02 0.213 0.248 B 293.0 269.0 4 29 29 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.3e-99 338.7 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3K5VA P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.8272 11.0249 BBAminus -129.03, -178.81 -148.62, 103.08 -90.49, -4.28 302.25, 133.06 63.11, 53.01 in-in in 8.2222 Saltbr-in 2.8352 HRD-in -81.75, -55.21 87.7, -18.23 in-out-in SNCioi out-in ActLoopNT-out 16.3689 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.52, 121.82 APE9-dihe-in -113.18, 143.79 APE8-dihe-in -83.6, 88.45 APE8-rot-na 28.73 APE67-dihe-in -74.9, -7.51 -50.51, -43.0 APE12-dist-na 15.7887 APE11-dist-na 11.6924 APE10-dist-na 8.4451 APE9-dist-in 7.7803 None None None XRAY 1.74 0.201 0.231 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3K5VB P00520 229 510 1123.0 STJ:60001,STI:60002 Allosteric,Type2 Inactive DFGout 13.7649 11.0764 BBAminus -130.59, 178.94 -144.92, 105.3 -91.47, 1.18 305.46, 130.21 51.7, 50.11 in-in in 8.2219 Saltbr-in 2.8668 HRD-in -85.29, -53.14 86.12, -16.51 in-out-in SNCioi out-in ActLoopNT-out 16.4024 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.28, 125.5 APE9-dihe-in -111.48, 141.99 APE8-dihe-in -82.96, 81.2 APE8-rot-na 29.67 APE67-dihe-in -69.06, -10.18 -42.49, -48.14 APE12-dist-na 15.5836 APE11-dist-na 11.5044 APE10-dist-na 8.5983 APE9-dist-in 7.7555 None None None XRAY 1.74 0.201 0.231 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 3k5v Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD4A P00520 229 510 1123.0 FYW:60603,STI:60604 Allosteric,Type2 Inactive DFGout 13.7764 10.9351 BBAminus -130.79, -174.69 -153.04, 100.11 -89.33, 0.88 308.19, 134.35 53.16, 51.61 in-in in 8.1144 Saltbr-in 2.8706 HRD-in -79.72, -53.57 88.06, -19.16 in-out-in SNCioi out-in ActLoopNT-out 16.4097 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.86, 116.72 APE9-dihe-in -109.35, 142.84 APE8-dihe-in -86.21, 87.25 APE8-rot-na 23.52 APE67-dihe-in -69.15, -11.0 -46.61, -47.58 APE12-dist-na 15.7751 APE11-dist-na 11.7898 APE10-dist-na 8.3351 APE9-dist-in 7.8592 None None None XRAY 2.03 0.183 0.223 A 293.0 281.0 1 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD4B P00520 229 510 1123.0 FYW:60601,STI:60602 Allosteric,Type2 Inactive DFGout 13.8473 11.0365 BBAminus -132.33, -177.63 -150.45, 101.55 -90.95, -0.99 307.99, 135.01 52.91, 55.37 in-in in 8.1545 Saltbr-in 2.9282 HRD-in -79.19, -55.7 86.14, -16.91 in-out-in SNCioi out-in ActLoopNT-out 16.5243 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -114.49, 127.44 APE9-dihe-in -117.65, 140.28 APE8-dihe-in -83.09, 79.07 APE8-rot-na 27.61 APE67-dihe-in -65.5, -15.42 -38.27, -50.77 APE12-dist-na 15.5651 APE11-dist-na 11.2452 APE10-dist-na 8.3706 APE9-dist-in 7.8777 None None None XRAY 2.03 0.183 0.223 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd4 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD6A P00520 229 510 1123.0 FYH:60602,STI:60603 Allosteric,Type2 Inactive DFGout 13.7876 10.8987 BBAminus -118.54, -176.91 -146.68, 104.9 -90.05, -6.03 304.11, 138.72 66.96, 55.15 in-in in 8.2952 Saltbr-in 2.8153 HRD-in -88.34, -54.67 91.97, -25.73 in-out-in SNCioi out-in ActLoopNT-out 16.456 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.42, 121.54 APE9-dihe-in -110.97, 144.39 APE8-dihe-in -82.04, 86.81 APE8-rot-na 32.54 APE67-dihe-in -76.73, -9.19 -49.14, -40.38 APE12-dist-na 15.6429 APE11-dist-na 11.6814 APE10-dist-na 8.157 APE9-dist-in 7.7625 None None None XRAY 2.3 0.178 0.238 A 293.0 280.0 2 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3OY3A P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 12.9466 9.007 BBAminus -137.29, -169.78 -157.65, 128.99 -111.75, 11.85 289.0, 94.91 50.98, 52.65 in-in in 7.8674 Saltbr-in 2.9891 HRD-in -74.78, -52.15 78.88, -9.23 in-out-in SNCioi out-in ActLoopNT-out 15.5658 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.56, 121.47 APE9-dihe-in -112.4, 142.91 APE8-dihe-in -82.9, 85.53 APE8-rot-na 34.55 APE67-dihe-in -73.05, -8.51 -46.67, -46.08 APE12-dist-na 15.6711 APE11-dist-na 11.5488 APE10-dist-na 8.3152 APE9-dist-in 7.9262 T315I None None XRAY 1.95 0.22 0.266 A 284.0 283.0 0 29 29 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3OY3B P00520 229 511 1123.0 XY3:60001 Type2 Inactive DFGout 13.0435 8.8062 BBAminus -137.08, -175.15 -152.62, 125.15 -107.82, 7.08 288.46, 102.59 51.48, 58.3 in-in in 7.8642 Saltbr-in 2.4712 HRD-in -70.89, -52.75 81.95, -16.85 in-out-in SNCioi out-in ActLoopNT-out 15.7399 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.39, 125.75 APE9-dihe-in -114.93, 142.91 APE8-dihe-in -80.63, 91.02 APE8-rot-na 31.59 APE67-dihe-in -73.68, -7.56 -52.87, -45.41 APE12-dist-na 15.7295 APE11-dist-na 11.5248 APE10-dist-na 8.2656 APE9-dist-in 7.9883 T315I None None XRAY 1.95 0.22 0.266 B 284.0 283.0 0 29 29 0 [[242, 495]] 1.0 3oy3 Mus musculus TYR_ABL1_MOUSE TYR 5.2e-100 340.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3IK3A P00520 229 513 1123.0 0LI:60001 Type2 Inactive DFGout 13.5039 9.4383 BBAminus -139.29, -179.88 -153.49, 108.65 -85.72, -9.94 290.6, 95.91 72.02, 48.56 in-in in 7.934 Saltbr-in 2.5375 HRD-in -70.15, -60.9 90.87, -12.1 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.42, 120.77 APE9-dihe-in -114.74, 139.96 APE8-dihe-in -82.31, 89.85 APE8-rot-na 32.91 APE67-dihe-in -77.22, -7.68 -48.36, -44.8 APE12-dist-na 16.0102 APE11-dist-na 11.8397 APE10-dist-na 8.4563 APE9-dist-in 7.993 T315I None None XRAY 1.9 0.216 0.258 A 288.0 279.0 6 29 23 6 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3IK3B P00520 229 513 1123.0 0LI:60002 Type2 Inactive DFGout 13.4975 9.1697 BBAminus -129.46, 178.53 -148.47, 114.27 -91.94, -7.12 286.37, 101.01 64.82, 50.27 in-in in 7.9919 Saltbr-in 2.6552 HRD-in -76.51, -54.44 85.69, -10.99 in-out-in SNCioi out-in ActLoopNT-out 15.7027 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.88, 123.97 APE9-dihe-in -117.43, 141.07 APE8-dihe-in -76.99, 85.79 APE8-rot-na 29.46 APE67-dihe-in -85.08, -5.45 -41.61, -41.71 APE12-dist-na 15.8259 APE11-dist-na 11.5962 APE10-dist-na 8.603 APE9-dist-in 7.8512 T315I None None XRAY 1.9 0.216 0.258 B 288.0 285.0 0 29 29 0 [[242, 495]] 1.0 3ik3 Mus musculus TYR_ABL1_MOUSE TYR 5.5e-100 339.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3OXZA P00520 229 511 1123.0 0LI:60001 Type2 Inactive DFGout 13.3158 8.9403 BBAminus -130.11, -171.24 -154.37, 127.79 -115.42, 5.71 286.77, 98.95 48.45, 62.42 in-in in 8.0038 Saltbr-in 3.005 HRD-in -71.2, -52.05 81.82, -16.86 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -90.47, 133.09 APE9-dihe-in -119.78, 140.42 APE8-dihe-in -76.32, 77.74 APE8-rot-na 32.13 APE67-dihe-in -76.96, -8.32 -43.1, -46.11 APE12-dist-na 15.3775 APE11-dist-na 10.76 APE10-dist-na 8.339 APE9-dist-out 8.088 None None None XRAY 2.2 0.218 0.261 A 284.0 267.0 16 29 19 10 [[242, 495]] 1.0 3oxz Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KFAA P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.2442 8.8197 BBAminus -142.27, -176.56 -152.63, 125.74 -107.34, 5.74 288.91, 88.99 58.04, 50.09 in-in in 8.1404 Saltbr-in 2.7169 HRD-in -73.85, -48.11 82.13, -13.17 in-out-in SNCioi out-in ActLoopNT-out 15.6397 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.63, 125.03 APE9-dihe-in -114.41, 145.91 APE8-dihe-in -84.21, 85.96 APE8-rot-na 33.66 APE67-dihe-in -73.3, -8.53 -52.44, -41.01 APE12-dist-na 15.8025 APE11-dist-na 11.654 APE10-dist-na 8.6661 APE9-dist-in 7.7127 None None None XRAY 1.22 0.201 0.201 A 288.0 283.0 0 29 29 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3KFAB P00520 229 511 1123.0 B91:60001 Type2 Inactive DFGout 13.2546 8.8052 BBAminus -140.52, -176.97 -152.37, 125.18 -106.35, 4.72 288.28, 89.94 58.68, 49.29 in-in in 8.1374 Saltbr-in 2.6923 HRD-in -74.33, -47.79 81.87, -12.97 in-out-in SNCioi out-in ActLoopNT-out 15.6035 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.66, 126.45 APE9-dihe-in -115.84, 145.74 APE8-dihe-in -82.6, 85.95 APE8-rot-na 33.9 APE67-dihe-in -74.2, -7.78 -53.04, -40.32 APE12-dist-na 15.7892 APE11-dist-na 11.659 APE10-dist-na 8.7035 APE9-dist-in 7.698 None None None XRAY 1.22 0.201 0.201 B 288.0 283.0 0 29 29 0 [[242, 495]] 1.0 3kfa Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 340.9 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1FPUA P00520 229 499 1123.0 PRC:60001 Type2 Inactive DFGout 13.4179 10.9488 BBAminus -141.9, -166.28 -158.13, 103.8 -90.94, 3.8 310.97, 131.54 54.26, 50.94 in-in in 8.4034 Saltbr-in 2.871 HRD-in -86.77, -50.24 77.96, -12.71 in-out-in SNCioi out-in ActLoopNT-out 16.2249 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.73, 138.95 APE9-dihe-in -131.33, 134.86 APE8-dihe-in -81.8, 82.67 APE8-rot-na 35.36 APE67-dihe-in -73.73, -7.55 -41.73, -44.76 APE12-dist-na 14.1131 APE11-dist-na 12.2538 APE10-dist-na 8.1396 APE9-dist-in 7.4423 None None None XRAY 2.4 0.239 0.264 A 293.0 271.0 0 29 29 0 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1FPUB P00520 229 499 1123.0 PRC:60002 Type2 Inactive DFGout 13.5087 10.529 BBAminus -141.62, -165.58 -158.88, 104.33 -91.66, 4.75 310.99, 131.8 53.0, 51.49 in-in in 8.316 Saltbr-in 3.0589 HRD-in -85.61, -50.1 76.84, -10.82 in-out-in SNCioi out-in ActLoopNT-out 16.231 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.53, 139.19 APE9-dihe-in -131.35, 134.07 APE8-dihe-in -80.76, 81.97 APE8-rot-na 34.87 APE67-dihe-in -70.5, -12.0 -41.07, -44.99 APE12-dist-na 14.1073 APE11-dist-na 12.255 APE10-dist-na 8.1365 APE9-dist-in 7.4503 None None None XRAY 2.4 0.239 0.264 B 293.0 266.0 5 29 24 5 [[242, 495]] 1.0 1fpu Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1IEPA P00520 229 498 1123.0 STI:60201 Type2 Inactive DFGout 13.5616 10.8609 BBAminus -137.03, -172.54 -153.96, 97.64 -87.18, 3.68 308.79, 136.8 52.65, 57.65 in-in in 8.3113 Saltbr-in 3.1021 HRD-in -76.11, -58.44 87.76, -16.49 in-out-in SNCioi out-in ActLoopNT-out 16.3209 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.61, 141.98 APE9-dihe-in -135.62, 143.41 APE8-dihe-in -82.32, 86.58 APE8-rot-na 35.1 APE67-dihe-in -73.95, -4.51 -43.85, -43.13 APE12-dist-na 14.642 APE11-dist-na 11.7988 APE10-dist-na 8.4893 APE9-dist-in 7.3405 None None None XRAY 2.1 0.231 0.262 A 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1IEPB P00520 229 498 1123.0 STI:60202 Type2 Inactive DFGout 13.5287 10.801 BBAminus -143.94, -178.65 -148.11, 93.74 -82.6, -2.47 307.48, 137.57 62.07, 48.88 in-out in 8.1853 Saltbr-out 4.3676 HRD-in -84.56, -56.22 87.89, -19.72 out-out-in SNCooi out-in ActLoopNT-out 14.9721 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -125.54, 140.59 APE9-dihe-in -139.53, 149.49 APE8-dihe-in -85.03, 86.81 APE8-rot-na 36.13 APE67-dihe-in -68.22, -7.81 -42.13, -46.9 APE12-dist-na 15.6933 APE11-dist-na 11.543 APE10-dist-na 8.6711 APE9-dist-in 7.1993 None None None XRAY 2.1 0.231 0.262 B 293.0 270.0 0 29 29 0 [[242, 495]] 1.0 1iep Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1OPJA P00520 229 510 1123.0 STI:60003 Type2 Inactive DFGout 13.7798 10.8261 BBAminus -128.07, -174.54 -152.92, 98.6 -89.13, 6.29 307.36, 137.21 49.4, 56.53 in-in in 8.2618 Saltbr-in 2.6832 HRD-in -85.47, -54.47 85.47, -15.74 in-out-out SNCioo out-out ActLoopNT-out 16.1376 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -110.59, 111.76 APE9-dihe-in -105.57, 139.7 APE8-dihe-in -87.32, 84.08 APE8-rot-na 31.83 APE67-dihe-in -67.58, -10.57 -46.59, -43.84 APE12-dist-na 15.8128 APE11-dist-na 11.6321 APE10-dist-na 8.4599 APE9-dist-out 8.0909 None None None XRAY 1.75 0.21 0.242 A 293.0 282.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1OPJB P00520 229 512 1123.0 STI:60004 Type2 Inactive DFGout 13.9109 11.3214 BBAminus -132.18, -179.0 -150.37, 98.45 -86.36, 2.32 310.86, 130.49 52.69, 56.75 in-in in 8.0553 Saltbr-in 2.8815 HRD-in -79.51, -55.82 87.48, -17.62 in-out-in SNCioi out-in ActLoopNT-out 16.1636 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -111.86, 121.43 APE9-dihe-in -116.41, 142.51 APE8-dihe-in -88.15, 80.96 APE8-rot-na 32.33 APE67-dihe-in -69.25, -7.13 -40.7, -49.19 APE12-dist-na 15.7903 APE11-dist-na 11.8331 APE10-dist-na 8.395 APE9-dist-in 7.8063 None None None XRAY 1.75 0.21 0.242 B 293.0 284.0 0 29 29 0 [[242, 495]] 1.0 1opj Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 2HZNA P00520 229 502 1123.0 KIN:60600 Type2 Inactive DFGout 14.958 9.6719 BBAminus -139.88, -164.81 -155.74, 124.37 -98.42, -30.89 272.45, 94.35 80.92, 43.41 in-in in 8.1612 Saltbr-in 2.5756 HRD-in -62.12, -53.83 87.41, -26.87 in-out-in SNCioi out-in ActLoopNT-out 16.1634 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -109.47, 150.88 APE9-dihe-in -140.18, 135.21 APE8-dihe-in -65.94, 87.96 APE8-rot-na 341.9 APE67-dihe-in -68.13, -18.79 -49.49, -50.03 APE12-dist-na 15.039 APE11-dist-na 10.6139 APE10-dist-na 8.5822 APE9-dist-in 7.3169 None None None XRAY 2.7 0.267 0.314 A 293.0 269.0 5 29 29 0 [[242, 495]] 1.0 2hzn Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 6HD6B P00520 229 510 1123.0 STI:60601 Type2 Inactive DFGout 13.8292 11.1791 BBAminus -125.12, -175.5 -154.19, 103.09 -91.96, 21.1 310.97, 128.7 31.22, 64.2 in-in in 8.3943 Saltbr-in 3.0721 HRD-in -85.22, -51.46 85.37, -17.4 in-out-in SNCioi out-in ActLoopNT-out 16.3685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -87.94, 122.32 APE9-dihe-in -101.91, 149.19 APE8-dihe-in -81.38, 82.15 APE8-rot-na 19.67 APE67-dihe-in -78.93, -7.66 -49.97, -39.1 APE12-dist-na 15.412 APE11-dist-na 11.1785 APE10-dist-na 8.7641 APE9-dist-in 7.7824 None None None XRAY 2.3 0.178 0.238 B 293.0 279.0 3 29 29 0 [[242, 495]] 1.0 6hd6 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MS9A P00520 230 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6604 10.9917 BBAminus -129.69, -177.84 -146.05, 100.92 -85.37, -0.41 305.07, 135.33 63.76, 47.34 in-in in 8.3409 Saltbr-in 3.1533 HRD-in -79.52, -52.27 83.07, -15.37 in-out-in SNCioi out-in ActLoopNT-out 16.086 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -121.38, 129.78 APE9-dihe-in -118.07, 145.91 APE8-dihe-in -88.08, 91.81 APE8-rot-na 29.01 APE67-dihe-in -75.19, -6.62 -50.02, -40.18 APE12-dist-na 14.3629 APE11-dist-na 12.2197 APE10-dist-na 8.6387 APE9-dist-in 7.5316 None None None XRAY 1.8 0.188 0.234 A 293.0 261.0 8 29 27 2 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MS9B P00520 229 498 1123.0 STI:60001,MS9:60516 Type2,Allosteric Inactive DFGout 13.6482 10.9444 BBAminus -132.64, -179.46 -143.9, 102.88 -90.37, 5.1 303.67, 135.83 60.73, 51.4 in-in in 8.2919 Saltbr-in 2.7815 HRD-in -83.7, -52.15 86.58, -11.15 in-out-in SNCioi out-in ActLoopNT-out 15.33 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -129.02, 135.09 APE9-dihe-in -128.33, 142.16 APE8-dihe-in -86.14, 87.78 APE8-rot-na 36.31 APE67-dihe-in -76.28, -2.93 -48.89, -43.33 APE12-dist-na 15.5909 APE11-dist-na 13.452 APE10-dist-na 8.8559 APE9-dist-in 7.6276 None None None XRAY 1.8 0.188 0.234 B 293.0 267.0 3 29 29 0 [[242, 495]] 1.0 3ms9 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSA P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.6024 10.9266 BBAminus -140.22, -178.36 -147.69, 104.27 -89.71, -2.47 299.0, 139.73 66.29, 43.35 in-in in 8.3889 Saltbr-in 3.0948 HRD-in -74.19, -56.0 83.94, -13.58 in-out-in SNCioi out-in ActLoopNT-out 16.2188 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.21, 134.82 APE9-dihe-in -123.76, 144.56 APE8-dihe-in -89.25, 91.24 APE8-rot-na 26.73 APE67-dihe-in -76.81, -6.98 -52.23, -37.7 APE12-dist-na 14.4457 APE11-dist-na 11.9742 APE10-dist-na 8.5807 APE9-dist-in 7.4405 None None None XRAY 1.95 0.172 0.22 A 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSB P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5999 10.8202 BBAminus -134.26, 179.26 -142.74, 100.94 -88.95, 3.79 301.55, 135.44 59.27, 50.16 in-in in 8.1878 Saltbr-in 2.7291 HRD-in -84.32, -52.44 85.34, -18.42 in-out-in SNCioi out-in ActLoopNT-out 15.3256 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -118.6, 137.91 APE9-dihe-in -132.77, 140.13 APE8-dihe-in -80.01, 89.25 APE8-rot-na 23.44 APE67-dihe-in -77.65, -10.14 -50.83, -40.78 APE12-dist-na 15.5761 APE11-dist-na 13.4863 APE10-dist-na 8.8 APE9-dist-in 7.4545 None None None XRAY 1.95 0.172 0.22 B 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSC P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5909 10.9626 BBAminus -138.8, 179.7 -144.18, 103.21 -86.54, 1.5 302.89, 134.71 58.1, 46.5 in-in in 8.0875 Saltbr-in 3.0475 HRD-in -78.89, -57.09 86.43, -17.08 in-out-in SNCioi out-in ActLoopNT-out 16.1082 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -116.32, 131.91 APE9-dihe-in -126.48, 145.59 APE8-dihe-in -89.99, 90.94 APE8-rot-na 26.3 APE67-dihe-in -77.37, -6.31 -51.14, -38.56 APE12-dist-na 14.5938 APE11-dist-na 11.8497 APE10-dist-na 8.4632 APE9-dist-in 7.442 None None None XRAY 1.95 0.172 0.22 C 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3MSSD P00520 232 498 1123.0 STI:60001,MS7:60516 Type2,Allosteric Inactive DFGout 13.5469 10.7877 BBAminus -134.13, -175.99 -148.24, 101.28 -89.17, 5.19 302.32, 137.83 56.24, 49.56 in-in in 8.1921 Saltbr-in 2.7895 HRD-in -83.98, -55.12 89.03, -15.39 in-out-in SNCioi out-in ActLoopNT-out 15.5394 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -124.05, 133.37 APE9-dihe-in -131.92, 141.87 APE8-dihe-in -80.66, 89.72 APE8-rot-na 31.84 APE67-dihe-in -74.69, -8.69 -52.73, -42.14 APE12-dist-na 15.622 APE11-dist-na 13.6062 APE10-dist-na 8.7829 APE9-dist-in 7.554 None None None XRAY 1.95 0.172 0.22 D 293.0 260.0 7 29 28 1 [[242, 495]] 1.0 3mss Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1M52A P00520 232 502 1123.0 P17:119 Type1.5_Back Inactive DFGout 12.7932 10.7534 None -60.22, 138.56 -89.44, -13.76 -71.29, 150.54 62.03, 63.6 85.22, 23.45 in-in in 7.8946 Saltbr-in 2.7072 HRD-out -103.5, 129.11 -84.41, -9.26 in-out-in SNCioi out-in ActLoopNT-out 5.5228 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.32, 126.97 APE9-dihe-in -125.58, 158.53 APE8-dihe-in -60.22, 106.23 APE8-rot-na 28.98 APE67-dihe-in -61.13, -15.48 -48.91, -53.77 APE12-dist-na 18.5358 APE11-dist-na 14.0518 APE10-dist-na 17.1001 APE9-dist-in 6.3399 None None None XRAY 2.6 0.211 0.254 A 293.0 271.0 0 29 29 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1M52B P00520 232 503 1123.0 P17:120 Type1.5_Back Inactive DFGout 12.7809 10.9966 None -67.54, 135.07 -84.58, -12.33 -70.24, 151.37 63.17, 66.62 85.76, 18.68 in-in in 8.0957 Saltbr-in 2.8231 HRD-out -106.35, 123.08 -78.82, -9.36 in-out-in SNCioi out-in ActLoopNT-out 5.5791 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -108.32, 130.43 APE9-dihe-in -127.38, 164.85 APE8-dihe-in -67.06, 104.95 APE8-rot-na 28.73 APE67-dihe-in -58.93, -14.72 -46.9, -55.31 APE12-dist-na 18.9417 APE11-dist-na 14.1825 APE10-dist-na 17.0323 APE9-dist-in 6.3696 None None None XRAY 2.6 0.211 0.254 B 293.0 272.0 0 29 29 0 [[242, 495]] 1.0 1m52 Mus musculus TYR_ABL1_MOUSE TYR 2.9e-100 340.8 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 1OPKA P00520 64 512 1123.0 P16:60002 Type1.5_Back Inactive DFGout 12.8526 11.5242 None -65.37, 134.02 -116.02, 33.5 -83.75, 159.92 53.06, 70.43 67.02, 7.91 in-in in 7.9566 Saltbr-in 2.9399 HRD-in -97.25, -54.03 73.87, -6.88 in-out-in SNCioi out-in ActLoopNT-out 5.5583 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.1, 127.8 APE9-dihe-in -117.64, 161.56 APE8-dihe-in -80.21, 93.15 APE8-rot-na 30.65 APE67-dihe-in -63.48, -19.22 -41.98, -48.41 APE12-dist-na 19.4802 APE11-dist-na 14.7534 APE10-dist-na 17.431 APE9-dist-in 7.1248 D363N None None XRAY 1.8 0.196 0.221 A 495.0 449.0 0 29 29 0 [[242, 495]] 1.0 1opk Mus musculus TYR_ABL1_MOUSE TYR 5.5e-99 337.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
ABL1 ABL1_MOUSE 3DK7B P00520 233 505 1123.0 SX7:2 Type1 Inactive None 999.0 999.0 None -70.09, 131.91 -99.1, 30.92 -47.67, -78.64 999.0, 999.0 -116.53, 59.69 in-none in 8.1534 Saltbr-none 999.0 HRD-in -96.35, -57.33 75.78, -1.22 none-out-in SNCnoi out-in ActLoopNT-out 5.6353 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.0, 138.44 APE9-dihe-in -123.96, 150.21 APE8-dihe-in -64.33, 99.33 APE8-rot-na 21.28 APE67-dihe-in -72.95, -10.57 -50.9, -44.43 APE12-dist-na 19.1355 APE11-dist-na 14.4826 APE10-dist-na 17.474 APE9-dist-in 7.0192 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 B 277.0 269.0 4 29 29 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.6e-100 341.0 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1