Ligand: YFV

Total number of chains: 2
Active chains: 2
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 8GMCA

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
OTHER AAK1 AAK1_HUMAN 8GMCA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 34 - 330 0 None None AP2-associated protein kinase 1
OTHER AAK1 AAK1_HUMAN 8GMCB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 31 - 330 0 None None AP2-associated protein kinase 1

Ligand: YFV

Total number of chains: 6
Active chains: 6
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 100.0% 7RJ6A

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER AAK1 AAK1_HUMAN 8GMCA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 34 - 330 0 None None AP2-associated protein kinase 1 Homo sapiens
OTHER AAK1 AAK1_HUMAN 8GMCB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 31 - 330 0 None None AP2-associated protein kinase 1 Homo sapiens
OTHER AAK1 AAK1_MOUSE 7LVHB 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 329 0 None None AP2-associated protein kinase 1 Mus musculus
OTHER AAK1 AAK1_MOUSE 7LVIB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
OTHER AAK1 AAK1_MOUSE 7RJ6A 2.132 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
OTHER AAK1 AAK1_MOUSE 7RJ8B 2.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV, PG6 Type1, Allosteric 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus

Ligand: YFV

Total number of chains: 4
Active chains: 4
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7RJ6A

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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER AAK1 AAK1_MOUSE 7LVHB 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 329 0 None None AP2-associated protein kinase 1 Mus musculus
OTHER AAK1 AAK1_MOUSE 7LVIB 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 35 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
OTHER AAK1 AAK1_MOUSE 7RJ6A 2.132 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV Type1 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus
OTHER AAK1 AAK1_MOUSE 7RJ8B 2.59 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii YFV, PG6 Type1, Allosteric 26 - 330 0 None None AP2-associated protein kinase 1 Mus musculus