OTHER_AAK1 (AP2-associated protein kinase 1)

Total number of chains: 13
Active chains: 13
Uniprot: AAK1_HUMAN
Kinase Domain Residues: 46 - 313
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 100.0% AF-Q2M2I8-K1A

Hover over column headers for tooltip help.

Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AAK1 AF-Q2M2I8-K1A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 6.0898 13.1573 BLAminus -130.76, 177.11 65.46, 72.88 -86.17, 13.75 306.15, 100.85 -62.63, -26.92 in-in in 8.6944 Saltbr-in 2.6952 HRD-in -71.29, -40.47 67.96, -14.25 in-in-in SNCiii in-in ActLoopNT-in 2.7672 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, 1.5 APE9-dihe-na -133.56, 144.49 APE8-dihe-in -85.09, 124.69 APE8-rot-in 302.03 APE67-dihe-in -65.48, -12.52 -47.91, -50.11 APE12-dist-in 12.1054 APE11-dist-in 8.3861 APE10-dist-in 4.1768 APE9-dist-in 3.7633 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 36 36 0 [[46, 313]] 1.0 AF-Q2M2I8-K1 OTHER_AAK1_HUMAN OTHER 2.4e-41 147.8 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AF-Q2M2I8-K3A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 5.9088 13.3704 BLAminus -128.17, 175.79 57.92, 95.09 -102.83, 15.36 298.99, 95.97 -62.48, -26.93 in-in in 8.8052 Saltbr-in 2.6864 HRD-in -73.71, -40.34 66.99, -5.58 in-in-in SNCiii in-in ActLoopNT-in 2.8022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.85, -5.0 APE9-dihe-na -133.21, 117.79 APE8-dihe-in -58.72, 127.19 APE8-rot-in 304.31 APE67-dihe-in -63.7, -12.57 -50.37, -47.6 APE12-dist-in 12.0248 APE11-dist-in 8.4592 APE10-dist-in 4.1293 APE9-dist-in 3.4894 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 36 36 0 [[46, 313]] 1.0 AF-Q2M2I8-K3 OTHER_AAK1_HUMAN OTHER 2.4e-41 147.8 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 4WSQA Q2M2I8 29 345 961.0 KSA:405 Type1 Active DFGin 6.307 13.7534 BLAminus -126.2, -179.67 69.61, 90.76 -108.14, 19.69 293.57, 82.96 -69.52, -19.34 in-in in 9.5238 Saltbr-in 3.051 HRD-in -67.42, -46.62 67.64, 3.19 in-in-in SNCiii in-in ActLoopNT-in 2.8695 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.1, -8.47 APE9-dihe-na -120.84, 162.67 APE8-dihe-in -101.84, 124.39 APE8-rot-in 300.18 APE67-dihe-in -59.62, -25.15 -50.19, -46.52 APE12-dist-in 12.3768 APE11-dist-in 8.8309 APE10-dist-in 4.4743 APE9-dist-in 3.6746 None None None XRAY 1.95 0.182 0.208 A 317.0 317.0 0 36 36 0 [[46, 313]] 1.0 4wsq OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 4WSQB Q2M2I8 33 342 961.0 KSA:404 Type1 Active DFGin 6.4483 13.4911 BLAminus -125.14, -178.62 72.01, 91.87 -111.17, 20.84 297.62, 84.5 -70.3, -20.72 in-in in 9.3105 Saltbr-in 2.7431 HRD-in -70.2, -48.3 68.24, 1.29 in-in-in SNCiii in-in ActLoopNT-in 2.8464 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -7.92 APE9-dihe-na -118.96, 162.19 APE8-dihe-in -104.95, 123.2 APE8-rot-in 302.88 APE67-dihe-in -62.15, -24.37 -51.37, -45.33 APE12-dist-in 12.2082 APE11-dist-in 8.5573 APE10-dist-in 4.2501 APE9-dist-in 3.7443 None None None XRAY 1.95 0.182 0.208 B 317.0 310.0 0 36 36 0 [[46, 313]] 1.0 4wsq OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 8GMCA Q2M2I8 34 330 961.0 YFV:401 Type1 Active DFGin 6.2956 13.3438 BLAminus -132.35, 179.07 63.58, 102.47 -106.53, 19.35 292.32, 96.59 -60.5, -34.69 in-in in 8.5015 Saltbr-in 2.7401 HRD-in -65.3, -44.13 71.44, -0.05 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.27, -5.42 APE9-dihe-na -117.59, 149.82 APE8-dihe-in -99.03, 116.29 APE8-rot-in 299.63 APE67-dihe-in -50.9, -25.95 -44.55, -54.08 APE12-dist-in 12.2292 APE11-dist-in 8.5323 APE10-dist-in 4.1896 APE9-dist-in 3.8809 None None None XRAY 2.5 0.228 0.256 A 318.0 293.0 4 36 36 0 [[46, 313]] 1.0 8gmc OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 8GMCB Q2M2I8 31 330 961.0 YFV:401 Type1 Active DFGin 6.6132 13.4444 BLAminus -132.15, -179.67 62.85, 102.24 -105.78, 18.46 292.58, 96.33 -60.62, -34.17 in-in in 8.465 Saltbr-in 2.9369 HRD-in -65.77, -42.15 71.41, -5.73 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.13, -3.18 APE9-dihe-na -121.52, 151.08 APE8-dihe-in -97.1, 121.04 APE8-rot-in 308.13 APE67-dihe-in -59.64, -26.78 -53.61, -40.63 APE12-dist-in 12.1812 APE11-dist-in 8.453 APE10-dist-in 4.1545 APE9-dist-in 3.9786 None None None XRAY 2.5 0.228 0.256 B 318.0 294.0 5 36 36 0 [[46, 313]] 1.0 8gmc OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 8GMDA Q2M2I8 34 329 961.0 ZRR:401 Type1 Active DFGin 6.1668 13.3321 BLAminus -127.52, 174.84 65.86, 97.82 -104.03, 21.57 300.09, 93.49 -64.42, -30.01 in-in in 8.5756 Saltbr-in 2.7839 HRD-in -64.68, -46.09 71.69, -3.04 in-in-in SNCiii in-in ActLoopNT-in 2.9742 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.71, -15.11 APE9-dihe-na -111.33, 160.49 APE8-dihe-in -104.37, 121.78 APE8-rot-in 304.75 APE67-dihe-in -58.75, -28.21 -47.17, -46.33 APE12-dist-in 12.1626 APE11-dist-in 8.4335 APE10-dist-in 4.1468 APE9-dist-in 3.5664 None None None XRAY 2.2 0.233 0.25 A 318.0 294.0 2 36 36 0 [[46, 313]] 1.0 8gmd OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 8GMDB Q2M2I8 29 330 961.0 ZRR:401 Type1 Active DFGin 6.3724 13.4776 BLAminus -123.19, 179.01 67.0, 97.52 -104.44, 17.42 296.06, 83.59 -61.74, -25.96 in-in in 8.4316 Saltbr-in 2.7776 HRD-in -64.58, -45.6 71.56, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.9573 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.95, -11.7 APE9-dihe-na -117.06, 155.74 APE8-dihe-in -98.45, 121.78 APE8-rot-in 305.28 APE67-dihe-in -59.45, -28.48 -46.11, -46.72 APE12-dist-in 12.1776 APE11-dist-in 8.3744 APE10-dist-in 4.1429 APE9-dist-in 3.5971 None None None XRAY 2.2 0.233 0.25 B 318.0 299.0 3 36 36 0 [[46, 313]] 1.0 8gmd OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 9QB5A Q2M2I8 29 343 961.0 F7I:60401 Type1 Active DFGin 6.406 13.358 BLAminus -132.26, 177.36 64.71, 93.28 -102.58, 23.65 295.99, 87.8 -68.89, -14.08 in-in in 8.4517 Saltbr-in 2.5766 HRD-in -65.82, -48.18 75.53, -3.07 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.0, -10.1 APE9-dihe-na -117.28, 159.33 APE8-dihe-in -101.85, 125.23 APE8-rot-in 303.31 APE67-dihe-in -61.58, -23.49 -52.0, -46.22 APE12-dist-in 12.1582 APE11-dist-in 8.502 APE10-dist-in 4.1257 APE9-dist-in 3.6319 None None None XRAY 2.0 0.199 0.227 A 318.0 313.0 2 36 36 0 [[46, 313]] 1.0 9qb5 OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 9QB5B Q2M2I8 34 342 961.0 F7I:60401 Type1 Active DFGin 6.4569 13.0394 BLAminus -136.45, 178.27 73.68, 94.2 -109.77, 25.54 300.89, 108.71 -73.91, -11.3 in-in in 8.0922 Saltbr-in 2.4615 HRD-in -66.48, -48.55 75.65, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.9081 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.0, -6.97 APE9-dihe-na -121.88, 160.23 APE8-dihe-in -103.81, 124.81 APE8-rot-in 304.19 APE67-dihe-in -60.83, -28.74 -52.63, -42.77 APE12-dist-in 12.174 APE11-dist-in 8.5775 APE10-dist-in 4.3028 APE9-dist-in 3.6645 None None None XRAY 2.0 0.199 0.227 B 318.0 309.0 0 36 36 0 [[46, 313]] 1.0 9qb5 OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 5L4QA Q2M2I8 33 335 961.0 LKB:401 Type1 Active DFGin 6.0047 13.2273 BLAminus -132.85, -177.94 63.93, 92.35 -114.27, 19.37 301.1, 98.45 -80.74, -11.63 in-in in 8.685 Saltbr-in 2.708 HRD-in -67.77, -48.62 71.48, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.9221 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.55, -17.02 APE9-dihe-na -109.84, 154.17 APE8-dihe-in -96.17, 123.72 APE8-rot-in 302.79 APE67-dihe-in -62.67, -23.02 -45.97, -51.51 APE12-dist-in 11.9991 APE11-dist-in 8.3501 APE10-dist-in 4.067 APE9-dist-in 3.4826 None None None XRAY 1.97 0.208 0.227 A 346.0 293.0 10 36 36 0 [[46, 313]] 1.0 5l4q OTHER_AAK1_HUMAN OTHER 4.8e-41 147.2 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 5L4QB Q2M2I8 33 333 961.0 LKB:401 Type1 Active DFGin 6.0008 13.2527 BLAminus -132.29, -178.13 64.06, 92.67 -114.66, 18.46 300.35, 97.82 -80.3, -11.3 in-in in 8.5651 Saltbr-in 2.7137 HRD-in -67.84, -48.94 70.89, 2.68 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.29, -16.57 APE9-dihe-na -109.81, 154.98 APE8-dihe-in -96.35, 124.27 APE8-rot-in 304.05 APE67-dihe-in -62.49, -22.16 -46.27, -52.25 APE12-dist-in 11.9555 APE11-dist-in 8.4008 APE10-dist-in 4.043 APE9-dist-in 3.5048 None None None XRAY 1.97 0.208 0.227 B 346.0 287.0 14 36 36 0 [[46, 313]] 1.0 5l4q OTHER_AAK1_HUMAN OTHER 4.8e-41 147.2 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 5TE0A Q2M2I8 27 345 961.0 XIN:60401 Type1 Active DFGin 6.1767 13.7286 BLAminus -133.95, 173.97 66.46, 103.31 -110.15, 22.69 304.86, 94.85 -65.74, -20.86 in-in in 9.0545 Saltbr-in 3.4906 HRD-in -62.42, -46.29 70.69, -4.02 in-in-in SNCiii in-in ActLoopNT-in 2.8421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -11.26 APE9-dihe-na -114.88, 156.03 APE8-dihe-in -99.05, 119.5 APE8-rot-in 300.83 APE67-dihe-in -58.27, -25.82 -45.89, -49.71 APE12-dist-in 12.1407 APE11-dist-in 8.3978 APE10-dist-in 4.1462 APE9-dist-in 3.7311 None None None XRAY 1.9 0.182 0.199 A 347.0 315.0 4 36 36 0 [[46, 313]] 1.0 5te0 OTHER_AAK1_HUMAN OTHER 4.8e-41 147.2 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1

OTHER_AAK1 (AP2-associated protein kinase 1)

Total number of chains: 23
Active chains: 22
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 22 95.7% AF-Q2M2I8-K1A
DFGin ABAminus 1 4.3% 7LVIA

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AAK1 AAK1_HUMAN AF-Q2M2I8-K1A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 6.0898 13.1573 BLAminus -130.76, 177.11 65.46, 72.88 -86.17, 13.75 306.15, 100.85 -62.63, -26.92 in-in in 8.6944 Saltbr-in 2.6952 HRD-in -71.29, -40.47 67.96, -14.25 in-in-in SNCiii in-in ActLoopNT-in 2.7672 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, 1.5 APE9-dihe-na -133.56, 144.49 APE8-dihe-in -85.09, 124.69 APE8-rot-in 302.03 APE67-dihe-in -65.48, -12.52 -47.91, -50.11 APE12-dist-in 12.1054 APE11-dist-in 8.3861 APE10-dist-in 4.1768 APE9-dist-in 3.7633 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 36 36 0 [[46, 313]] 1.0 AF-Q2M2I8-K1 Homo sapiens OTHER_AAK1_HUMAN OTHER 2.4e-41 147.8 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN AF-Q2M2I8-K3A Q2M2I8 38 321 961.0 No_ligand No_ligand Active DFGin 5.9088 13.3704 BLAminus -128.17, 175.79 57.92, 95.09 -102.83, 15.36 298.99, 95.97 -62.48, -26.93 in-in in 8.8052 Saltbr-in 2.6864 HRD-in -73.71, -40.34 66.99, -5.58 in-in-in SNCiii in-in ActLoopNT-in 2.8022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.85, -5.0 APE9-dihe-na -133.21, 117.79 APE8-dihe-in -58.72, 127.19 APE8-rot-in 304.31 APE67-dihe-in -63.7, -12.57 -50.37, -47.6 APE12-dist-in 12.0248 APE11-dist-in 8.4592 APE10-dist-in 4.1293 APE9-dist-in 3.4894 None None None AF2 -1.0 1.0 1.0 A 284.0 284.0 0 36 36 0 [[46, 313]] 1.0 AF-Q2M2I8-K3 Homo sapiens OTHER_AAK1_HUMAN OTHER 2.4e-41 147.8 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 4WSQA Q2M2I8 29 345 961.0 KSA:405 Type1 Active DFGin 6.307 13.7534 BLAminus -126.2, -179.67 69.61, 90.76 -108.14, 19.69 293.57, 82.96 -69.52, -19.34 in-in in 9.5238 Saltbr-in 3.051 HRD-in -67.42, -46.62 67.64, 3.19 in-in-in SNCiii in-in ActLoopNT-in 2.8695 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.1, -8.47 APE9-dihe-na -120.84, 162.67 APE8-dihe-in -101.84, 124.39 APE8-rot-in 300.18 APE67-dihe-in -59.62, -25.15 -50.19, -46.52 APE12-dist-in 12.3768 APE11-dist-in 8.8309 APE10-dist-in 4.4743 APE9-dist-in 3.6746 None None None XRAY 1.95 0.182 0.208 A 317.0 317.0 0 36 36 0 [[46, 313]] 1.0 4wsq Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 4WSQB Q2M2I8 33 342 961.0 KSA:404 Type1 Active DFGin 6.4483 13.4911 BLAminus -125.14, -178.62 72.01, 91.87 -111.17, 20.84 297.62, 84.5 -70.3, -20.72 in-in in 9.3105 Saltbr-in 2.7431 HRD-in -70.2, -48.3 68.24, 1.29 in-in-in SNCiii in-in ActLoopNT-in 2.8464 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.84, -7.92 APE9-dihe-na -118.96, 162.19 APE8-dihe-in -104.95, 123.2 APE8-rot-in 302.88 APE67-dihe-in -62.15, -24.37 -51.37, -45.33 APE12-dist-in 12.2082 APE11-dist-in 8.5573 APE10-dist-in 4.2501 APE9-dist-in 3.7443 None None None XRAY 1.95 0.182 0.208 B 317.0 310.0 0 36 36 0 [[46, 313]] 1.0 4wsq Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 8GMCA Q2M2I8 34 330 961.0 YFV:401 Type1 Active DFGin 6.2956 13.3438 BLAminus -132.35, 179.07 63.58, 102.47 -106.53, 19.35 292.32, 96.59 -60.5, -34.69 in-in in 8.5015 Saltbr-in 2.7401 HRD-in -65.3, -44.13 71.44, -0.05 in-in-in SNCiii in-in ActLoopNT-in 2.984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.27, -5.42 APE9-dihe-na -117.59, 149.82 APE8-dihe-in -99.03, 116.29 APE8-rot-in 299.63 APE67-dihe-in -50.9, -25.95 -44.55, -54.08 APE12-dist-in 12.2292 APE11-dist-in 8.5323 APE10-dist-in 4.1896 APE9-dist-in 3.8809 None None None XRAY 2.5 0.228 0.256 A 318.0 293.0 4 36 36 0 [[46, 313]] 1.0 8gmc Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 8GMCB Q2M2I8 31 330 961.0 YFV:401 Type1 Active DFGin 6.6132 13.4444 BLAminus -132.15, -179.67 62.85, 102.24 -105.78, 18.46 292.58, 96.33 -60.62, -34.17 in-in in 8.465 Saltbr-in 2.9369 HRD-in -65.77, -42.15 71.41, -5.73 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.13, -3.18 APE9-dihe-na -121.52, 151.08 APE8-dihe-in -97.1, 121.04 APE8-rot-in 308.13 APE67-dihe-in -59.64, -26.78 -53.61, -40.63 APE12-dist-in 12.1812 APE11-dist-in 8.453 APE10-dist-in 4.1545 APE9-dist-in 3.9786 None None None XRAY 2.5 0.228 0.256 B 318.0 294.0 5 36 36 0 [[46, 313]] 1.0 8gmc Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 8GMDA Q2M2I8 34 329 961.0 ZRR:401 Type1 Active DFGin 6.1668 13.3321 BLAminus -127.52, 174.84 65.86, 97.82 -104.03, 21.57 300.09, 93.49 -64.42, -30.01 in-in in 8.5756 Saltbr-in 2.7839 HRD-in -64.68, -46.09 71.69, -3.04 in-in-in SNCiii in-in ActLoopNT-in 2.9742 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.71, -15.11 APE9-dihe-na -111.33, 160.49 APE8-dihe-in -104.37, 121.78 APE8-rot-in 304.75 APE67-dihe-in -58.75, -28.21 -47.17, -46.33 APE12-dist-in 12.1626 APE11-dist-in 8.4335 APE10-dist-in 4.1468 APE9-dist-in 3.5664 None None None XRAY 2.2 0.233 0.25 A 318.0 294.0 2 36 36 0 [[46, 313]] 1.0 8gmd Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 8GMDB Q2M2I8 29 330 961.0 ZRR:401 Type1 Active DFGin 6.3724 13.4776 BLAminus -123.19, 179.01 67.0, 97.52 -104.44, 17.42 296.06, 83.59 -61.74, -25.96 in-in in 8.4316 Saltbr-in 2.7776 HRD-in -64.58, -45.6 71.56, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.9573 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.95, -11.7 APE9-dihe-na -117.06, 155.74 APE8-dihe-in -98.45, 121.78 APE8-rot-in 305.28 APE67-dihe-in -59.45, -28.48 -46.11, -46.72 APE12-dist-in 12.1776 APE11-dist-in 8.3744 APE10-dist-in 4.1429 APE9-dist-in 3.5971 None None None XRAY 2.2 0.233 0.25 B 318.0 299.0 3 36 36 0 [[46, 313]] 1.0 8gmd Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.6 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 9QB5A Q2M2I8 29 343 961.0 F7I:60401 Type1 Active DFGin 6.406 13.358 BLAminus -132.26, 177.36 64.71, 93.28 -102.58, 23.65 295.99, 87.8 -68.89, -14.08 in-in in 8.4517 Saltbr-in 2.5766 HRD-in -65.82, -48.18 75.53, -3.07 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.0, -10.1 APE9-dihe-na -117.28, 159.33 APE8-dihe-in -101.85, 125.23 APE8-rot-in 303.31 APE67-dihe-in -61.58, -23.49 -52.0, -46.22 APE12-dist-in 12.1582 APE11-dist-in 8.502 APE10-dist-in 4.1257 APE9-dist-in 3.6319 None None None XRAY 2.0 0.199 0.227 A 318.0 313.0 2 36 36 0 [[46, 313]] 1.0 9qb5 Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 9QB5B Q2M2I8 34 342 961.0 F7I:60401 Type1 Active DFGin 6.4569 13.0394 BLAminus -136.45, 178.27 73.68, 94.2 -109.77, 25.54 300.89, 108.71 -73.91, -11.3 in-in in 8.0922 Saltbr-in 2.4615 HRD-in -66.48, -48.55 75.65, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.9081 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.0, -6.97 APE9-dihe-na -121.88, 160.23 APE8-dihe-in -103.81, 124.81 APE8-rot-in 304.19 APE67-dihe-in -60.83, -28.74 -52.63, -42.77 APE12-dist-in 12.174 APE11-dist-in 8.5775 APE10-dist-in 4.3028 APE9-dist-in 3.6645 None None None XRAY 2.0 0.199 0.227 B 318.0 309.0 0 36 36 0 [[46, 313]] 1.0 9qb5 Homo sapiens OTHER_AAK1_HUMAN OTHER 3.6e-41 147.5 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 5L4QA Q2M2I8 33 335 961.0 LKB:401 Type1 Active DFGin 6.0047 13.2273 BLAminus -132.85, -177.94 63.93, 92.35 -114.27, 19.37 301.1, 98.45 -80.74, -11.63 in-in in 8.685 Saltbr-in 2.708 HRD-in -67.77, -48.62 71.48, 2.06 in-in-in SNCiii in-in ActLoopNT-in 2.9221 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.55, -17.02 APE9-dihe-na -109.84, 154.17 APE8-dihe-in -96.17, 123.72 APE8-rot-in 302.79 APE67-dihe-in -62.67, -23.02 -45.97, -51.51 APE12-dist-in 11.9991 APE11-dist-in 8.3501 APE10-dist-in 4.067 APE9-dist-in 3.4826 None None None XRAY 1.97 0.208 0.227 A 346.0 293.0 10 36 36 0 [[46, 313]] 1.0 5l4q Homo sapiens OTHER_AAK1_HUMAN OTHER 4.8e-41 147.2 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 5L4QB Q2M2I8 33 333 961.0 LKB:401 Type1 Active DFGin 6.0008 13.2527 BLAminus -132.29, -178.13 64.06, 92.67 -114.66, 18.46 300.35, 97.82 -80.3, -11.3 in-in in 8.5651 Saltbr-in 2.7137 HRD-in -67.84, -48.94 70.89, 2.68 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.29, -16.57 APE9-dihe-na -109.81, 154.98 APE8-dihe-in -96.35, 124.27 APE8-rot-in 304.05 APE67-dihe-in -62.49, -22.16 -46.27, -52.25 APE12-dist-in 11.9555 APE11-dist-in 8.4008 APE10-dist-in 4.043 APE9-dist-in 3.5048 None None None XRAY 1.97 0.208 0.227 B 346.0 287.0 14 36 36 0 [[46, 313]] 1.0 5l4q Homo sapiens OTHER_AAK1_HUMAN OTHER 4.8e-41 147.2 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_HUMAN 5TE0A Q2M2I8 27 345 961.0 XIN:60401 Type1 Active DFGin 6.1767 13.7286 BLAminus -133.95, 173.97 66.46, 103.31 -110.15, 22.69 304.86, 94.85 -65.74, -20.86 in-in in 9.0545 Saltbr-in 3.4906 HRD-in -62.42, -46.29 70.69, -4.02 in-in-in SNCiii in-in ActLoopNT-in 2.8421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -11.26 APE9-dihe-na -114.88, 156.03 APE8-dihe-in -99.05, 119.5 APE8-rot-in 300.83 APE67-dihe-in -58.27, -25.82 -45.89, -49.71 APE12-dist-in 12.1407 APE11-dist-in 8.3978 APE10-dist-in 4.1462 APE9-dist-in 3.7311 None None None XRAY 1.9 0.182 0.199 A 347.0 315.0 4 36 36 0 [[46, 313]] 1.0 5te0 Homo sapiens OTHER_AAK1_HUMAN OTHER 4.8e-41 147.2 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7LVHA Q3UHJ0 34 328 959.0 YFS:401 Type1 Active DFGin 6.3815 13.1586 BLAminus -99.27, -147.3 14.04, 114.8 -121.99, 26.42 298.51, 87.91 -70.89, -12.69 in-in in 8.6326 Saltbr-in 2.9865 HRD-in -65.25, -42.59 66.7, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.9339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.0, -6.79 APE9-dihe-na -118.74, 158.73 APE8-dihe-in -102.63, 127.81 APE8-rot-in 327.57 APE67-dihe-in -51.65, -23.05 -49.85, -58.32 APE12-dist-in 12.2326 APE11-dist-in 8.6319 APE10-dist-in 4.2873 APE9-dist-in 3.7712 None None None XRAY 2.65 0.267 0.299 A 318.0 284.0 11 36 34 2 [[46, 313]] 1.0 7lvh Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7LVHB Q3UHJ0 35 329 959.0 YFV:401 Type1 Active DFGin 6.305 13.462 BLAminus -109.39, -171.27 52.7, 102.9 -109.75, 14.5 296.74, 93.05 -60.15, -20.34 in-in in 8.5725 Saltbr-in 2.9247 HRD-in -64.33, -41.66 66.46, -2.89 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.01, -10.47 APE9-dihe-na -112.81, 152.03 APE8-dihe-in -104.75, 117.86 APE8-rot-in 298.94 APE67-dihe-in -52.25, -35.41 -40.96, -54.57 APE12-dist-in 12.4236 APE11-dist-in 8.6752 APE10-dist-in 4.2649 APE9-dist-in 3.8852 None None None XRAY 2.65 0.267 0.299 B 318.0 281.0 14 36 34 2 [[46, 313]] 1.0 7lvh Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7LVIB Q3UHJ0 35 330 959.0 YFV:401 Type1 Active DFGin 6.5554 13.9557 BLAminus -120.74, -177.87 58.36, 103.46 -109.53, 15.49 286.96, 91.82 -62.65, -18.35 in-in in 8.6464 Saltbr-in 2.9382 HRD-in -65.69, -47.95 71.36, -2.95 in-in-in SNCiii in-in ActLoopNT-in 2.7984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.16, -5.91 APE9-dihe-na -123.61, 155.71 APE8-dihe-in -99.3, 117.77 APE8-rot-in 306.22 APE67-dihe-in -52.8, -28.0 -40.05, -53.5 APE12-dist-in 12.1358 APE11-dist-in 8.5899 APE10-dist-in 4.2334 APE9-dist-in 3.7808 None None None XRAY 2.2 0.219 0.241 B 318.0 288.0 8 36 36 0 [[46, 313]] 1.0 7lvi Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ6A Q3UHJ0 26 330 959.0 YFV:401 Type1 Active DFGin 6.5122 13.3768 BLAminus -125.62, 169.71 67.71, 96.16 -104.68, 24.3 300.02, 93.63 -68.93, -22.4 in-in in 8.5967 Saltbr-in 2.7099 HRD-in -65.12, -47.31 74.51, -5.09 in-in-in SNCiii in-in ActLoopNT-in 2.8935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.26, -12.99 APE9-dihe-na -116.7, 155.82 APE8-dihe-in -97.42, 121.54 APE8-rot-in 304.46 APE67-dihe-in -58.17, -28.42 -45.34, -49.66 APE12-dist-in 12.1363 APE11-dist-in 8.6182 APE10-dist-in 4.2728 APE9-dist-in 3.6627 None None None XRAY 2.132 0.202 0.215 A 318.0 305.0 0 36 36 0 [[46, 313]] 1.0 7rj6 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ6B Q3UHJ0 32 330 959.0 5OI:401 Type1 Active DFGin 6.386 13.2644 BLAminus -136.98, -179.6 61.47, 90.79 -102.58, 19.8 300.28, 93.44 -74.01, -20.13 in-in in 8.7043 Saltbr-in 2.7308 HRD-in -65.76, -48.0 74.66, -11.15 in-in-in SNCiii in-in ActLoopNT-in 2.8975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.51, -10.49 APE9-dihe-na -120.36, 163.0 APE8-dihe-in -104.78, 122.31 APE8-rot-in 303.78 APE67-dihe-in -58.21, -28.47 -45.49, -49.71 APE12-dist-in 11.9714 APE11-dist-in 8.4144 APE10-dist-in 4.1372 APE9-dist-in 3.7792 None None None XRAY 2.132 0.202 0.215 B 318.0 299.0 0 36 36 0 [[46, 313]] 1.0 7rj6 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ7A Q3UHJ0 26 330 959.0 5P6:401 Type1 Active DFGin 6.4175 13.2295 BLAminus -119.48, 174.96 57.07, 109.64 -122.04, 21.88 302.38, 85.37 -70.96, -15.13 in-in in 8.8767 Saltbr-in 2.7471 HRD-in -69.47, -41.35 71.48, -9.14 in-in-in SNCiii in-in ActLoopNT-in 2.9302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.51, -3.09 APE9-dihe-na -122.59, 149.49 APE8-dihe-in -97.34, 124.1 APE8-rot-in 304.72 APE67-dihe-in -57.28, -27.01 -46.87, -50.73 APE12-dist-in 12.1476 APE11-dist-in 8.4871 APE10-dist-in 4.133 APE9-dist-in 3.7038 None None None XRAY 2.124 0.23 0.241 A 318.0 304.0 1 36 36 0 [[46, 313]] 1.0 7rj7 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ7B Q3UHJ0 31 330 959.0 5P6:401 Type1 Active DFGin 6.0891 13.1308 BLAminus -124.6, -178.84 57.9, 88.94 -99.65, 26.07 303.29, 101.38 -78.17, -15.56 in-in in 8.8917 Saltbr-in 2.7552 HRD-in -71.2, -45.26 74.74, -14.68 in-in-in SNCiii in-in ActLoopNT-in 2.9313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.73, -6.79 APE9-dihe-na -120.3, 157.4 APE8-dihe-in -99.84, 124.85 APE8-rot-in 305.17 APE67-dihe-in -58.1, -26.76 -48.79, -48.64 APE12-dist-in 12.0925 APE11-dist-in 8.4564 APE10-dist-in 4.1132 APE9-dist-in 3.8598 None None None XRAY 2.124 0.23 0.241 B 318.0 300.0 0 36 36 0 [[46, 313]] 1.0 7rj7 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ8A Q3UHJ0 33 329 959.0 5QI:401,PG6:402 Type1,Allosteric Active DFGin 5.8996 12.8884 BLAminus -133.43, 178.44 53.42, 101.65 -103.66, 23.97 304.98, 112.99 -67.68, -29.68 in-in in 8.3964 Saltbr-in 2.7456 HRD-in -63.24, -44.02 66.63, -0.51 in-in-in SNCiii in-in ActLoopNT-in 2.5201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.11, -10.27 APE9-dihe-na -117.76, 158.13 APE8-dihe-in -102.68, 119.66 APE8-rot-in 301.04 APE67-dihe-in -54.01, -28.74 -43.37, -51.03 APE12-dist-in 12.1372 APE11-dist-in 8.4799 APE10-dist-in 4.0816 APE9-dist-in 3.8112 None None None XRAY 2.59 0.187 0.222 A 318.0 297.0 0 36 36 0 [[46, 313]] 1.0 7rj8 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ8B Q3UHJ0 26 330 959.0 YFV:401,PG6:402 Type1,Allosteric Active DFGin 6.1715 13.5947 BLAminus -125.6, -179.39 58.59, 102.41 -105.91, 18.84 291.4, 96.74 -62.2, -32.16 in-in in 8.5892 Saltbr-in 2.8156 HRD-in -63.34, -43.99 65.76, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.8659 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.14, -12.1 APE9-dihe-na -116.75, 157.99 APE8-dihe-in -101.55, 119.49 APE8-rot-in 301.75 APE67-dihe-in -54.59, -29.22 -43.63, -50.74 APE12-dist-in 12.1253 APE11-dist-in 8.5316 APE10-dist-in 4.1081 APE9-dist-in 3.8064 None None None XRAY 2.59 0.187 0.222 B 318.0 305.0 0 36 36 0 [[46, 313]] 1.0 7rj8 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7LVIA Q3UHJ0 34 330 959.0 YFY:401 Type1 Inactive DFGin 6.2747 13.1608 ABAminus -90.42, -24.8 -129.94, 143.17 -139.29, 27.72 306.54, 92.44 -75.37, -6.08 in-in in 8.7052 Saltbr-in 2.9639 HRD-in -66.79, -49.03 71.63, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.14, -3.93 APE9-dihe-na -125.59, 156.06 APE8-dihe-in -100.72, 117.66 APE8-rot-in 307.66 APE67-dihe-in -52.98, -27.5 -41.63, -52.86 APE12-dist-in 12.0745 APE11-dist-in 8.5387 APE10-dist-in 4.2106 APE9-dist-in 3.7825 None None None XRAY 2.2 0.219 0.241 A 318.0 294.0 3 36 36 0 [[46, 313]] 1.0 7lvi Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1

OTHER_AAK1 (AP2-associated protein kinase 1)

Total number of chains: 10
Active chains: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 90.0% 7RJ7B
DFGin ABAminus 1 10.0% 7LVIA

Hover over column headers for tooltip help.

Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AAK1 AAK1_MOUSE 7LVHA Q3UHJ0 34 328 959.0 YFS:401 Type1 Active DFGin 6.3815 13.1586 BLAminus -99.27, -147.3 14.04, 114.8 -121.99, 26.42 298.51, 87.91 -70.89, -12.69 in-in in 8.6326 Saltbr-in 2.9865 HRD-in -65.25, -42.59 66.7, -3.41 in-in-in SNCiii in-in ActLoopNT-in 2.9339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.0, -6.79 APE9-dihe-na -118.74, 158.73 APE8-dihe-in -102.63, 127.81 APE8-rot-in 327.57 APE67-dihe-in -51.65, -23.05 -49.85, -58.32 APE12-dist-in 12.2326 APE11-dist-in 8.6319 APE10-dist-in 4.2873 APE9-dist-in 3.7712 None None None XRAY 2.65 0.267 0.299 A 318.0 284.0 11 36 34 2 [[46, 313]] 1.0 7lvh Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7LVHB Q3UHJ0 35 329 959.0 YFV:401 Type1 Active DFGin 6.305 13.462 BLAminus -109.39, -171.27 52.7, 102.9 -109.75, 14.5 296.74, 93.05 -60.15, -20.34 in-in in 8.5725 Saltbr-in 2.9247 HRD-in -64.33, -41.66 66.46, -2.89 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.01, -10.47 APE9-dihe-na -112.81, 152.03 APE8-dihe-in -104.75, 117.86 APE8-rot-in 298.94 APE67-dihe-in -52.25, -35.41 -40.96, -54.57 APE12-dist-in 12.4236 APE11-dist-in 8.6752 APE10-dist-in 4.2649 APE9-dist-in 3.8852 None None None XRAY 2.65 0.267 0.299 B 318.0 281.0 14 36 34 2 [[46, 313]] 1.0 7lvh Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7LVIB Q3UHJ0 35 330 959.0 YFV:401 Type1 Active DFGin 6.5554 13.9557 BLAminus -120.74, -177.87 58.36, 103.46 -109.53, 15.49 286.96, 91.82 -62.65, -18.35 in-in in 8.6464 Saltbr-in 2.9382 HRD-in -65.69, -47.95 71.36, -2.95 in-in-in SNCiii in-in ActLoopNT-in 2.7984 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.16, -5.91 APE9-dihe-na -123.61, 155.71 APE8-dihe-in -99.3, 117.77 APE8-rot-in 306.22 APE67-dihe-in -52.8, -28.0 -40.05, -53.5 APE12-dist-in 12.1358 APE11-dist-in 8.5899 APE10-dist-in 4.2334 APE9-dist-in 3.7808 None None None XRAY 2.2 0.219 0.241 B 318.0 288.0 8 36 36 0 [[46, 313]] 1.0 7lvi Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ6A Q3UHJ0 26 330 959.0 YFV:401 Type1 Active DFGin 6.5122 13.3768 BLAminus -125.62, 169.71 67.71, 96.16 -104.68, 24.3 300.02, 93.63 -68.93, -22.4 in-in in 8.5967 Saltbr-in 2.7099 HRD-in -65.12, -47.31 74.51, -5.09 in-in-in SNCiii in-in ActLoopNT-in 2.8935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.26, -12.99 APE9-dihe-na -116.7, 155.82 APE8-dihe-in -97.42, 121.54 APE8-rot-in 304.46 APE67-dihe-in -58.17, -28.42 -45.34, -49.66 APE12-dist-in 12.1363 APE11-dist-in 8.6182 APE10-dist-in 4.2728 APE9-dist-in 3.6627 None None None XRAY 2.132 0.202 0.215 A 318.0 305.0 0 36 36 0 [[46, 313]] 1.0 7rj6 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ6B Q3UHJ0 32 330 959.0 5OI:401 Type1 Active DFGin 6.386 13.2644 BLAminus -136.98, -179.6 61.47, 90.79 -102.58, 19.8 300.28, 93.44 -74.01, -20.13 in-in in 8.7043 Saltbr-in 2.7308 HRD-in -65.76, -48.0 74.66, -11.15 in-in-in SNCiii in-in ActLoopNT-in 2.8975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.51, -10.49 APE9-dihe-na -120.36, 163.0 APE8-dihe-in -104.78, 122.31 APE8-rot-in 303.78 APE67-dihe-in -58.21, -28.47 -45.49, -49.71 APE12-dist-in 11.9714 APE11-dist-in 8.4144 APE10-dist-in 4.1372 APE9-dist-in 3.7792 None None None XRAY 2.132 0.202 0.215 B 318.0 299.0 0 36 36 0 [[46, 313]] 1.0 7rj6 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ7A Q3UHJ0 26 330 959.0 5P6:401 Type1 Active DFGin 6.4175 13.2295 BLAminus -119.48, 174.96 57.07, 109.64 -122.04, 21.88 302.38, 85.37 -70.96, -15.13 in-in in 8.8767 Saltbr-in 2.7471 HRD-in -69.47, -41.35 71.48, -9.14 in-in-in SNCiii in-in ActLoopNT-in 2.9302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.51, -3.09 APE9-dihe-na -122.59, 149.49 APE8-dihe-in -97.34, 124.1 APE8-rot-in 304.72 APE67-dihe-in -57.28, -27.01 -46.87, -50.73 APE12-dist-in 12.1476 APE11-dist-in 8.4871 APE10-dist-in 4.133 APE9-dist-in 3.7038 None None None XRAY 2.124 0.23 0.241 A 318.0 304.0 1 36 36 0 [[46, 313]] 1.0 7rj7 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ7B Q3UHJ0 31 330 959.0 5P6:401 Type1 Active DFGin 6.0891 13.1308 BLAminus -124.6, -178.84 57.9, 88.94 -99.65, 26.07 303.29, 101.38 -78.17, -15.56 in-in in 8.8917 Saltbr-in 2.7552 HRD-in -71.2, -45.26 74.74, -14.68 in-in-in SNCiii in-in ActLoopNT-in 2.9313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -104.73, -6.79 APE9-dihe-na -120.3, 157.4 APE8-dihe-in -99.84, 124.85 APE8-rot-in 305.17 APE67-dihe-in -58.1, -26.76 -48.79, -48.64 APE12-dist-in 12.0925 APE11-dist-in 8.4564 APE10-dist-in 4.1132 APE9-dist-in 3.8598 None None None XRAY 2.124 0.23 0.241 B 318.0 300.0 0 36 36 0 [[46, 313]] 1.0 7rj7 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ8A Q3UHJ0 33 329 959.0 5QI:401,PG6:402 Type1,Allosteric Active DFGin 5.8996 12.8884 BLAminus -133.43, 178.44 53.42, 101.65 -103.66, 23.97 304.98, 112.99 -67.68, -29.68 in-in in 8.3964 Saltbr-in 2.7456 HRD-in -63.24, -44.02 66.63, -0.51 in-in-in SNCiii in-in ActLoopNT-in 2.5201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.11, -10.27 APE9-dihe-na -117.76, 158.13 APE8-dihe-in -102.68, 119.66 APE8-rot-in 301.04 APE67-dihe-in -54.01, -28.74 -43.37, -51.03 APE12-dist-in 12.1372 APE11-dist-in 8.4799 APE10-dist-in 4.0816 APE9-dist-in 3.8112 None None None XRAY 2.59 0.187 0.222 A 318.0 297.0 0 36 36 0 [[46, 313]] 1.0 7rj8 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7RJ8B Q3UHJ0 26 330 959.0 YFV:401,PG6:402 Type1,Allosteric Active DFGin 6.1715 13.5947 BLAminus -125.6, -179.39 58.59, 102.41 -105.91, 18.84 291.4, 96.74 -62.2, -32.16 in-in in 8.5892 Saltbr-in 2.8156 HRD-in -63.34, -43.99 65.76, 0.54 in-in-in SNCiii in-in ActLoopNT-in 2.8659 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.14, -12.1 APE9-dihe-na -116.75, 157.99 APE8-dihe-in -101.55, 119.49 APE8-rot-in 301.75 APE67-dihe-in -54.59, -29.22 -43.63, -50.74 APE12-dist-in 12.1253 APE11-dist-in 8.5316 APE10-dist-in 4.1081 APE9-dist-in 3.8064 None None None XRAY 2.59 0.187 0.222 B 318.0 305.0 0 36 36 0 [[46, 313]] 1.0 7rj8 Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1
AAK1 AAK1_MOUSE 7LVIA Q3UHJ0 34 330 959.0 YFY:401 Type1 Inactive DFGin 6.2747 13.1608 ABAminus -90.42, -24.8 -129.94, 143.17 -139.29, 27.72 306.54, 92.44 -75.37, -6.08 in-in in 8.7052 Saltbr-in 2.9639 HRD-in -66.79, -49.03 71.63, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.14, -3.93 APE9-dihe-na -125.59, 156.06 APE8-dihe-in -100.72, 117.66 APE8-rot-in 307.66 APE67-dihe-in -52.98, -27.5 -41.63, -52.86 APE12-dist-in 12.0745 APE11-dist-in 8.5387 APE10-dist-in 4.2106 APE9-dist-in 3.7825 None None None XRAY 2.2 0.219 0.241 A 318.0 294.0 3 36 36 0 [[46, 313]] 1.0 7lvi Mus musculus OTHER_AAK1_MOUSE OTHER 6.7e-41 146.7 3.0 254.0 252.0 193 194 195 197 199 74 90 94 173 175 174 176.0 244 229 224 223 222 221 220 219 218 127 AP2-associated protein kinase 1