Activity: None (unassigned)

Total number of chains: 362
Active chains: 0
Total number of genes: 65
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 362 100.0% 4CT1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.602 14.979 BLAminus DFGAsp-rot-in -141.71, -172.51 72.43, 72.08 198.45, 9.85 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.146 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.357 APE11-dist-in 10.489 APE10-dist-in 5.018 APE9-dist-in 3.48 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311 284 0 0 0 0 [[82, 342]] 1.0 4ct1 AGC_PDPK1_HUMAN AGC 9.8e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD0A O15530 73 358 556.0 3Q4:370 Type1.5_Front None DFGin 6.584 14.791 BLAminus DFGAsp-rot-in -135.89, -173.14 73.55, 73.02 182.88, 14.17 -106.35, 12.12 281.49, 88.39 -54.84, -35.9 in-in in 8.526 Saltbr-in 2.573 HRD-in -72.98, -50.98 74.13, -9.69 in-in-none SNCiin in-none ActLoopNT-in 2.851 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -74.4, 123.75 APE8-rot-in 309.46 APE67-dihe-in -59.36, -28.41 -43.01, -50.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.765 None SEP241 SEP241 XRAY 1.99 0.191 0.231 A 312 274 12 0 0 12 [[82, 342]] 1.0 3qd0 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD4A O15530 71 358 556.0 3Q6:360 Type1.5_Front None DFGin 6.403 14.626 BLAminus DFGAsp-rot-in -137.72, -173.39 72.99, 75.84 178.14, 13.4 -110.69, 10.4 285.12, 91.81 -64.41, -29.28 in-in in 8.558 Saltbr-in 2.79 HRD-in -69.09, -51.69 76.33, -7.4 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.49 APE8-dihe-in -83.46, 122.24 APE8-rot-in 298.92 APE67-dihe-in -62.96, -22.94 -34.73, -56.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.12 None SEP241 SEP241 XRAY 2.3 0.199 0.244 A 312 276 12 0 0 12 [[82, 342]] 1.0 3qd4 AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2 12.865 BLAminus DFGAsp-rot-in -142.99, -166.55 58.77, 70.37 191.3, 11.27 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.166 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.152 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.603 APE11-dist-in 12.253 APE10-dist-in 6.595 APE9-dist-in 3.928 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596 322 9 0 0 0 [[254, 522]] 1.0 9ejm AGC_PRKCI_HUMAN AGC 5.3e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZC P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.35 12.565 BLAminus DFGAsp-rot-in -139.32, -164.03 47.55, 59.28 216.71, 4.72 -80.83, 61.9 308.74, 123.06 -106.89, -43.16 in-none in 9.109 Saltbr-none 999.0 HRD-in -73.5, -52.72 54.13, -0.86 none-in-in SNCnii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -173.36, 149.93 APE9-dihe-na 148.31, -160.27 APE8-dihe-in -114.43, 136.89 APE8-rot-in 309.46 APE67-dihe-in -57.11, -55.6 -58.53, -45.22 APE12-dist-in 9.055 APE11-dist-in 10.952 APE10-dist-in 5.478 APE9-dist-in 4.001 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 C 345 317 15 0 0 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZE P41743 255 587 596.0 AFU:601 Type1 None DFGin 6.957 12.846 BLAminus DFGAsp-rot-in -133.5, 178.86 66.81, 59.27 191.09, -13.89 -86.16, 63.15 305.7, 112.11 -113.68, -42.34 in-none in 8.722 Saltbr-none 999.0 HRD-in -57.41, -56.51 65.78, 5.3 none-in-in SNCnii in-in ActLoopNT-in 3.206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.18, 118.96 APE9-dihe-na -158.88, 157.43 APE8-dihe-in -112.73, 131.93 APE8-rot-in 318.3 APE67-dihe-in -62.09, -40.72 -61.87, -47.3 APE12-dist-in 9.305 APE11-dist-in 10.843 APE10-dist-in 5.436 APE9-dist-in 4.947 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 E 345 316 16 0 0 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZG P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.208 12.257 BLAminus DFGAsp-rot-in -148.76, -174.16 47.03, 68.4 201.65, 19.07 -82.07, 61.51 312.36, 107.63 -107.63, -40.38 in-none in 8.922 Saltbr-none 999.0 HRD-in -68.38, -50.26 58.54, -1.28 none-in-in SNCnii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 131.51 APE9-dihe-na -176.4, 176.09 APE8-dihe-in -116.21, 141.66 APE8-rot-in 312.23 APE67-dihe-in -65.11, -53.96 -57.73, -45.37 APE12-dist-in 8.827 APE11-dist-in 10.598 APE10-dist-in 4.936 APE9-dist-in 4.581 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 G 345 315 14 0 0 0 [[254, 522]] 1.0 6ilz AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 6BDLB Q13976 337 671 671.0 No_ligand No_ligand None DFGin 5.757 14.658 BLAminus DFGAsp-rot-in -124.78, 164.72 65.46, 95.48 191.95, 8.91 -109.07, 28.23 278.78, 64.61 -59.31, -33.14 in-in in 9.337 Saltbr-in 2.902 HRD-in -92.19, -47.19 78.26, -40.54 in-in-none SNCiin in-none ActLoopNT-in 2.877 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -122.13, 167.41 APE9-dihe-na 91.21, 161.43 APE8-dihe-in -67.63, 145.68 APE8-rot-none 999.0 APE67-dihe-in -70.27, -17.78 -60.28, -30.02 APE12-dist-in 7.598 APE11-dist-in 11.396 APE10-dist-in 5.795 APE9-dist-in 5.468 None TPO517 TPO517 XRAY 1.96 0.209 0.222 B 347 335 0 0 0 0 [[360, 619]] 1.0 6bdl AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S26B Q13464 6 402 1354.0 86K:60502 Type1 None DFGin 5.894 13.466 BLAminus DFGAsp-rot-in -142.81, 170.64 62.27, 84.33 180.92, 6.5 -99.22, -25.13 305.67, 98.88 -149.72, 999.0 in-in in 8.694 Saltbr-in 2.732 HRD-in -65.9, -38.81 79.64, -62.78 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.9, -32.72 999.0, -32.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 B 398 372 19 0 0 19 [[76, 338]] 1.0 7s26 AGC_ROCK1_HUMAN AGC 3.2e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEB Q13464 6 402 1354.0 B4J:60900 Type1.5_Front None DFGin 6.158 13.429 BLAminus DFGAsp-rot-in -143.39, 177.51 52.52, 73.92 190.34, 63.29 -94.42, 17.67 303.21, 98.37 -69.6, 5.07 in-in in 8.386 Saltbr-in 2.849 HRD-in -60.97, -51.26 69.54, -7.09 in-in-none SNCiin in-none ActLoopNT-in 3.235 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -78.48, -24.9 999.0, -22.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.229 0.246 B 415 351 34 0 0 9 [[76, 338]] 1.0 5wne AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 7JOVB O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.272 13.248 BLAminus DFGAsp-rot-in -142.1, 173.55 61.9, 71.69 203.02, 2.17 -93.43, 17.34 301.23, 105.57 -59.73, -16.68 in-in in 8.529 Saltbr-in 2.63 HRD-in -62.93, -47.02 69.4, -4.67 in-in-none SNCiin in-none ActLoopNT-in 3.098 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.0, -25.51 999.0, -48.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 B 395 378 11 0 0 8 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVD O75116 25 417 1388.0 VFS:501 Type1 None DFGin 6.243 13.357 BLAminus DFGAsp-rot-in -142.23, 173.1 61.78, 71.13 202.33, 1.42 -91.99, 20.3 301.3, 105.37 -69.47, 5.8 in-in in 8.671 Saltbr-in 2.701 HRD-in -54.87, -50.75 69.64, -5.46 in-in-none SNCiin in-none ActLoopNT-in 3.181 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -32.28 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 D 395 361 26 0 0 15 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVE O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.298 13.257 BLAminus DFGAsp-rot-in -140.47, 172.73 62.89, 72.53 202.72, 4.17 -94.4, 16.26 301.6, 106.26 -62.28, -16.19 in-in in 8.454 Saltbr-in 2.74 HRD-in -64.4, -46.2 69.9, -8.61 in-in-none SNCiin in-none ActLoopNT-in 3.126 ActLoopCT-none nonTYR APEdihe_aanii APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.7 APE8-rot-in 314.77 APE67-dihe-in -47.56, -31.02 -61.45, -35.46 APE12-dist-in 8.281 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 E 395 385 4 0 0 3 [[92, 354]] 1.0 7jov AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTB O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.165 13.121 BLAminus DFGAsp-rot-in -141.64, 172.76 58.92, 82.45 190.78, 5.59 -101.4, 24.85 302.94, 103.08 -64.88, -17.44 in-in in 8.698 Saltbr-in 2.739 HRD-in -62.47, -54.27 74.29, -0.05 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.99, -27.47 999.0, -54.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 B 399 376 13 0 0 8 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTD O75116 25 417 1388.0 VFA:501 Type1 None DFGin 6.159 13.16 BLAminus DFGAsp-rot-in -143.53, 169.89 61.25, 83.67 196.73, -7.36 -103.29, 25.02 302.97, 101.79 -66.66, -17.12 in-in in 8.73 Saltbr-in 2.74 HRD-in -61.61, -54.54 74.16, -0.65 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.7 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 D 399 360 27 0 0 15 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTE O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.214 13.058 BLAminus DFGAsp-rot-in -142.23, 169.06 60.85, 86.77 193.22, -6.74 -104.6, 25.19 302.23, 103.83 -66.31, -19.22 in-in in 8.573 Saltbr-in 2.668 HRD-in -56.89, -52.9 74.38, -3.32 in-in-none SNCiin in-none ActLoopNT-in 3.044 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.83 APE8-rot-in 306.93 APE67-dihe-in -51.63, -28.56 -78.96, -16.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 E 399 384 5 0 0 4 [[92, 354]] 1.0 7jnt AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NC O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.934 12.92 BLAminus DFGAsp-rot-in -146.55, 173.64 55.03, 95.19 187.78, -1.64 -112.85, 21.67 306.28, 93.38 -46.66, -30.29 in-in in 8.672 Saltbr-in 2.845 HRD-in -68.54, -48.47 75.35, -77.76 in-in-none SNCiin in-none ActLoopNT-in 3.188 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -54.16, -41.45 999.0, -46.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 C 399 378 12 0 0 6 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NE O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.955 12.867 BLAminus DFGAsp-rot-in -145.98, 174.14 54.43, 95.4 188.02, -2.13 -112.52, 20.29 306.04, 93.17 -47.1, -30.89 in-in in 8.6 Saltbr-in 2.849 HRD-in -68.77, -48.13 75.51, -77.25 in-in-none SNCiin in-none ActLoopNT-in 3.194 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.16, -41.37 999.0, -45.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 E 399 385 6 0 0 6 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NH O75116 25 417 1388.0 5YS:501 Type1 None DFGin 5.924 12.987 BLAminus DFGAsp-rot-in -147.12, 173.74 54.77, 95.23 188.53, -1.37 -112.35, 21.15 305.58, 93.62 -44.02, -31.78 in-in in 8.754 Saltbr-in 2.84 HRD-in -68.48, -48.35 74.56, -77.19 in-in-none SNCiin in-none ActLoopNT-in 3.194 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.65, -39.86 999.0, -45.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 H 399 366 23 0 0 15 [[92, 354]] 1.0 7p6n AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OC O75116 22 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.02 13.098 BLAminus DFGAsp-rot-in -129.77, 174.02 63.85, 83.94 193.25, 3.03 -107.22, 35.66 304.43, 101.43 -71.69, -46.2 in-in in 8.669 Saltbr-in 2.758 HRD-in -67.24, -41.54 67.86, 2.47 in-in-none SNCiin in-none ActLoopNT-in 3.222 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.0, -37.44 999.0, -18.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 C 399 377 13 0 0 7 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OH O75116 24 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.031 13.142 BLAminus DFGAsp-rot-in -130.18, 173.86 63.9, 84.23 193.08, 2.31 -107.39, 35.65 304.66, 101.19 -71.86, -45.96 in-in in 8.685 Saltbr-in 2.757 HRD-in -67.2, -41.51 67.93, 2.34 in-in-none SNCiin in-none ActLoopNT-in 3.218 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.17, -36.5 999.0, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 H 399 369 19 0 0 14 [[92, 354]] 1.0 7p6o AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
CAMK CAMK1 KCC1A_HUMAN 4FG7A Q14012 9 277 370.0 ATP:301 ATPlike None DFGin 6.733 14.558 BLAminus DFGAsp-rot-in -139.66, 179.97 56.25, 83.23 190.46, 14.91 -95.06, 23.76 286.93, 75.78 -57.64, -10.34 in-in in 9.756 Saltbr-in 2.988 HRD-in -66.62, -51.56 76.61, -3.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.43 APE8-dihe-in -71.0, 118.39 APE8-rot-in 317.82 APE67-dihe-inflip 114.74, -42.57 -57.89, 141.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.149 None None None XRAY 2.7 0.221 0.246 A 293 250 19 0 0 8 [[20, 276]] 1.0 4fg7 CAMK_CAMK1_HUMAN CAMK 6.9e-97 329.7 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK2B KCC2B_HUMAN 3BHHC Q13554 11 300 666.0 No_ligand No_ligand None DFGin 6.71 15.561 BLAminus DFGAsp-rot-in -127.39, 170.7 56.71, 87.91 197.17, -0.16 -95.68, 30.86 287.9, 73.89 -64.42, -32.77 in-none in 9.882 Saltbr-none 999.0 HRD-in -64.65, -47.9 68.02, -0.98 none-in-in SNCnii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.86, 139.41 APE9-dihe-na 123.37, 177.52 APE8-dihe-in -97.47, 130.93 APE8-rot-in 302.95 APE67-dihe-in -58.71, -19.0 -38.4, -58.17 APE12-dist-in 10.568 APE11-dist-in 10.982 APE10-dist-in 5.56 APE9-dist-in 3.711 None None None XRAY 2.4 0.225 0.275 C 295 284 6 0 0 0 [[14, 272]] 1.0 3bhh CAMK_CAMK2B_HUMAN CAMK 5.8e-96 326.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMK2B KCC2B_HUMAN 3BHHD Q13554 11 301 666.0 No_ligand No_ligand None DFGin 6.802 15.453 BLAminus DFGAsp-rot-in -126.24, 168.25 59.1, 86.86 200.92, -5.41 -95.28, 32.57 287.44, 73.92 -63.1, -40.24 in-none in 9.844 Saltbr-none 999.0 HRD-in -65.87, -48.06 64.84, 3.78 none-in-in SNCnii in-in ActLoopNT-in 2.879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.3, 137.4 APE9-dihe-na 124.14, 176.51 APE8-dihe-in -95.73, 129.7 APE8-rot-in 303.56 APE67-dihe-in -55.16, -23.5 -37.91, -59.42 APE12-dist-in 10.424 APE11-dist-in 11.055 APE10-dist-in 5.636 APE9-dist-in 3.692 None None None XRAY 2.4 0.225 0.275 D 295 285 6 0 0 0 [[14, 272]] 1.0 3bhh CAMK_CAMK2B_HUMAN CAMK 5.8e-96 326.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMK2B KCC2B_HUMAN 3BHHA Q13554 11 301 666.0 5CP:60600 Type1 None DFGin 6.941 14.261 BLAminus DFGAsp-rot-in -119.83, 171.12 57.42, 88.31 200.23, 0.16 -100.0, 29.89 288.66, 72.13 -58.77, -42.96 in-none in 8.614 Saltbr-none 999.0 HRD-in -62.89, -50.32 68.63, 3.81 none-in-in SNCnii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -169.08, 140.79 APE9-dihe-na 120.18, 176.33 APE8-dihe-in -99.01, 129.74 APE8-rot-in 301.95 APE67-dihe-in -59.35, -19.21 -38.64, -57.08 APE12-dist-in 10.452 APE11-dist-in 11.057 APE10-dist-in 5.631 APE9-dist-in 3.668 None None None XRAY 2.4 0.225 0.275 A 295 287 4 0 0 0 [[14, 272]] 1.0 3bhh CAMK_CAMK2B_HUMAN CAMK 5.8e-96 326.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMKK2 KKCC2_HUMAN 6BRCA Q96RR4 161 448 588.0 E5J:60501 Type1 None DFGin 6.926 15.179 BLAminus DFGAsp-rot-in -120.53, 171.08 63.24, 80.67 194.7, -7.93 -89.54, 24.54 291.35, 76.67 -66.53, -18.07 in-none in 9.862 Saltbr-none 999.0 HRD-in -61.64, -52.23 71.81, 8.67 none-in-in SNCnii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.08, 165.18 APE9-dihe-na 110.63, -166.81 APE8-dihe-in -91.91, 115.92 APE8-rot-in 307.72 APE67-dihe-in -63.99, -23.41 -49.22, -36.7 APE12-dist-in 9.729 APE11-dist-in 11.45 APE10-dist-in 5.523 APE9-dist-in 3.785 None None None XRAY 2.2 0.216 0.265 A 291 263 25 0 0 0 [[165, 446]] 1.0 6brc CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK DAPK1 DAPK1_HUMAN 3ZXTB P53355 7 276 1430.0 ACP:1279 ATPlike None DFGin 6.575 14.067 BLAminus DFGAsp-rot-in -121.46, -170.78 56.12, 80.76 194.67, -0.01 -103.93, 17.27 282.46, 79.2 -56.39, -19.56 in-in in 8.68 Saltbr-in 2.544 HRD-in -82.72, -41.2 65.14, 3.07 in-in-none SNCiin in-none ActLoopNT-in 2.949 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -71.62 APE8-rot-none 999.0 APE67-dihe-in -62.85, -24.88 -49.25, -41.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 B 285 253 17 0 0 10 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.6e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTC P53355 5 276 1430.0 ACP:1278 ATPlike None DFGin 6.764 14.238 BLAminus DFGAsp-rot-in -125.03, -178.44 64.54, 79.35 189.71, -29.05 -91.9, 24.57 287.83, 76.0 -66.08, -19.72 in-in in 9.392 Saltbr-in 2.719 HRD-in -72.23, -37.44 57.47, 4.52 in-in-none SNCiin in-none ActLoopNT-in 3.097 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -39.65, -42.12 999.0, -61.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 C 285 259 13 0 0 11 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.6e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTD P53355 7 276 1430.0 ACP:1277 ATPlike None DFGin 6.866 14.645 BLAminus DFGAsp-rot-in -115.85, 173.32 73.06, 78.3 182.49, 8.53 -92.76, 17.5 283.87, 68.26 -68.46, 25.44 in-in in 9.306 Saltbr-in 2.651 HRD-in -83.16, -46.35 65.92, 13.4 in-in-none SNCiin in-none ActLoopNT-in 3.108 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.61 APE8-rot-none 999.0 APE67-dihe-in -90.53, -15.22 -91.11, -7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 D 285 245 25 0 0 10 [[13, 275]] 1.0 3zxt CAMK_DAPK1_HUMAN CAMK 5.6e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BC P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.699 13.755 BLAminus DFGAsp-rot-in -145.08, 171.25 61.11, 107.16 194.76, -23.02 -112.51, 31.96 284.23, 68.66 -61.45, -37.77 in-in in 8.935 Saltbr-in 2.757 HRD-in -69.97, -44.39 78.89, -25.31 in-in-none SNCiin in-none ActLoopNT-in 3.064 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.67, -20.62 999.0, 173.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 C 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BD P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.711 13.906 BLAminus DFGAsp-rot-in -145.79, 167.53 68.59, 102.7 191.4, 22.7 -108.4, 30.91 282.62, 68.72 -66.3, -36.77 in-in in 8.983 Saltbr-in 3.408 HRD-in -69.48, -46.19 68.3, 18.38 in-in-none SNCiin in-none ActLoopNT-in 3.29 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -107.53, -10.82 999.0, -167.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 D 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BE P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.837 13.766 BLAminus DFGAsp-rot-in -139.59, 169.54 69.21, 97.38 197.7, -11.64 -104.17, 34.32 282.85, 67.94 -62.67, -38.94 in-in in 8.985 Saltbr-in 2.679 HRD-in -71.5, -45.64 70.77, 10.18 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -99.43, -1.37 999.0, -172.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 E 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BF P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.621 13.688 BLAminus DFGAsp-rot-in -142.07, 170.01 64.83, 98.1 194.23, -8.39 -101.81, 30.72 282.18, 71.32 -65.73, -35.15 in-in in 8.992 Saltbr-in 2.702 HRD-in -80.67, -40.94 69.92, -1.27 in-in-none SNCiin in-none ActLoopNT-in 3.032 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -101.55, -20.21 999.0, -176.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 F 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BG P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.714 14.011 BLAminus DFGAsp-rot-in -137.77, 173.07 72.09, 96.81 198.76, -11.58 -108.03, 29.22 281.02, 70.25 -63.92, -39.04 in-in in 9.1 Saltbr-in 2.657 HRD-in -83.07, -38.78 69.53, -15.76 in-in-none SNCiin in-none ActLoopNT-in 2.998 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -92.27, -2.06 999.0, -177.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 G 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BH P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.783 13.684 BLAminus DFGAsp-rot-in -141.56, 171.1 67.42, 98.81 196.01, -12.12 -106.45, 32.94 281.72, 69.09 -63.41, -39.6 in-in in 8.81 Saltbr-in 2.638 HRD-in -69.99, -38.96 66.77, 4.24 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.5, -19.42 999.0, -171.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 H 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BI P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.832 13.615 BLAminus DFGAsp-rot-in -144.83, 172.47 66.99, 98.69 195.79, -5.56 -105.77, 31.32 281.48, 70.34 -64.97, -40.42 in-none in 8.902 Saltbr-none 999.0 HRD-in -71.72, -44.4 66.46, 8.73 none-in-none SNCnin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.48, -16.84 999.0, -178.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 I 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BJ P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.585 13.726 BLAminus DFGAsp-rot-in -139.73, 172.93 64.33, 98.73 210.5, -37.24 -104.15, 24.81 279.87, 69.77 -58.59, -39.13 in-in in 8.829 Saltbr-in 2.742 HRD-in -76.49, -44.95 70.08, 8.99 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.9, -9.71 999.0, -177.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 J 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BK P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.649 13.886 BLAminus DFGAsp-rot-in -142.88, 173.31 64.15, 96.21 196.33, -13.36 -100.21, 30.51 279.28, 69.33 -63.22, -35.24 in-in in 8.951 Saltbr-in 2.645 HRD-in -75.63, -40.1 74.89, -28.49 in-in-none SNCiin in-none ActLoopNT-in 3.055 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -102.3, -6.38 999.0, -170.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 K 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BL P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.754 13.811 BLAminus DFGAsp-rot-in -149.62, 172.88 62.04, 95.8 192.5, -6.91 -100.2, 29.15 282.37, 69.48 -62.27, -33.8 in-in in 8.809 Saltbr-in 2.54 HRD-in -71.4, -42.73 71.32, 3.36 in-in-none SNCiin in-none ActLoopNT-in 3.086 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -93.48, -10.45 999.0, 179.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 L 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3G P49137 43 342 400.0 No_ligand No_ligand None DFGin 4.403 12.831 BLAminus DFGAsp-rot-in -153.55, -179.38 55.29, 116.19 195.59, -21.19 -117.23, 10.89 291.13, 75.69 -43.5, -24.71 in-in in 8.551 Saltbr-in 3.076 HRD-in -68.58, -34.89 71.69, -26.95 in-in-none SNCiin in-none ActLoopNT-in 3.413 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 G 324 276 24 0 0 14 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPJ P49137 48 328 400.0 No_ligand No_ligand None DFGin 4.458 13.647 BLAminus DFGAsp-rot-in -143.07, -174.18 50.09, 100.81 203.32, 0.75 -101.05, 31.78 269.94, 23.78 -83.21, -13.12 in-in in 8.094 Saltbr-in 3.175 HRD-in -63.4, -41.75 72.41, 26.69 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 J 326 225 56 0 0 18 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 8XX1A P49137 47 364 400.0 No_ligand No_ligand None DFGin 4.495 14.22 BLAminus DFGAsp-rot-in -125.96, 176.04 66.8, 91.73 198.72, -13.37 -96.65, 23.36 281.49, 65.79 -64.79, -14.16 in-in in 9.722 Saltbr-in 2.918 HRD-in -77.76, -52.02 68.77, 17.81 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.55 0.17 0.245 A 318 293 25 0 0 17 [[63, 325]] 1.0 8xx1 CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BA P49137 47 345 400.0 05B:1000 Type1 None DFGin 4.793 14.039 BLAminus DFGAsp-rot-in -133.6, 172.77 62.95, 100.31 194.37, 5.15 -104.2, 34.41 278.04, 66.12 -71.39, -34.54 in-in in 9.008 Saltbr-in 2.409 HRD-in -83.09, -47.43 74.93, -6.02 in-in-none SNCiin in-none ActLoopNT-in 3.112 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.52, -24.55 999.0, -179.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 A 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BB P49137 47 345 400.0 05B:1000 Type1 None DFGin 4.54 13.845 BLAminus DFGAsp-rot-in -142.13, 174.13 65.41, 93.56 196.46, -15.74 -99.51, 29.64 280.69, 67.08 -63.86, -41.52 in-in in 9.102 Saltbr-in 2.593 HRD-in -69.44, -43.13 63.83, 12.28 in-in-none SNCiin in-none ActLoopNT-in 3.017 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.51, -10.75 999.0, -173.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 B 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2YA P49137 46 345 400.0 P4O:3 Type1 None DFGin 4.51 13.529 BLAminus DFGAsp-rot-in -139.75, 177.52 74.44, 98.73 186.53, -3.11 -113.49, 19.9 276.17, 64.33 -51.78, -25.44 in-in in 8.652 Saltbr-in 2.551 HRD-in -79.45, -34.37 67.58, -79.89 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.294 0.334 A 319 259 41 0 0 18 [[63, 325]] 1.0 3r2y CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R30A P49137 46 345 400.0 CD2:1 Type1 None DFGin 4.276 13.617 BLAminus DFGAsp-rot-in -134.32, 174.77 70.14, 102.44 200.71, -21.75 -110.03, 21.6 275.81, 65.59 -62.22, -28.91 in-in in 8.733 Saltbr-in 2.951 HRD-in -89.69, -43.87 75.38, -83.52 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.284 0.332 A 319 264 36 0 0 16 [[63, 325]] 1.0 3r30 CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYA P49137 42 346 400.0 B18:1 Type1 None DFGin 4.58 13.976 BLAminus DFGAsp-rot-in -104.95, 167.84 71.31, 102.38 206.14, -43.02 -102.76, 24.4 284.1, 63.71 -59.24, -43.49 in-in in 8.6 Saltbr-in 2.624 HRD-in -76.66, -46.66 68.5, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.747 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -117.11, -34.75 999.0, -126.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 A 324 291 14 0 0 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYB P49137 44 345 400.0 B18:2 Type1 None DFGin 4.541 13.833 BLAminus DFGAsp-rot-in -135.83, 172.16 61.22, 108.34 200.82, -16.15 -113.0, 27.32 291.58, 57.74 -68.8, -9.66 in-in in 8.917 Saltbr-in 2.953 HRD-in -74.89, -51.86 41.3, 40.89 in-in-none SNCiin in-none ActLoopNT-in 2.826 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.0, -7.36 999.0, 151.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 B 324 283 19 0 0 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC P49137 42 359 400.0 STU:3 Type1 None DFGin 4.742 13.584 BLAminus DFGAsp-rot-in -137.32, 155.33 89.76, 83.85 211.43, -10.5 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.899 Saltbr-in 2.479 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.823 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324 307 11 0 0 11 [[63, 325]] 1.0 2pzy CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3A P49137 43 347 400.0 MK2:500 Type1 None DFGin 4.557 13.885 BLAminus DFGAsp-rot-in -135.8, -176.83 67.41, 90.4 187.55, 4.03 -94.59, 16.73 291.73, 73.07 -43.87, -36.09 in-in in 9.109 Saltbr-in 2.597 HRD-in -79.47, -55.59 75.47, 16.47 in-in-none SNCiin in-none ActLoopNT-in 3.09 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.87, 1.13 999.0, 124.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 A 324 288 17 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3B P49137 44 349 400.0 MK2:500 Type1 None DFGin 4.882 13.792 BLAminus DFGAsp-rot-in -132.93, 176.5 69.16, 89.86 190.89, -22.22 -95.19, 24.7 286.31, 75.82 -62.52, -14.87 in-in in 8.556 Saltbr-in 2.527 HRD-in -84.62, -39.61 65.84, 1.69 in-in-none SNCiin in-none ActLoopNT-in 3.033 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.96, -17.69 999.0, 172.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 B 324 290 16 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3C P49137 41 345 400.0 MK2:500 Type1 None DFGin 4.718 13.596 BLAminus DFGAsp-rot-in -138.58, -178.81 60.4, 102.94 204.15, -13.59 -104.46, 17.28 285.49, 73.29 -64.82, -5.96 in-in in 8.931 Saltbr-in 2.774 HRD-in -72.28, -46.2 69.4, 2.58 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.35, -6.27 999.0, 125.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 C 324 281 24 0 0 12 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3D P49137 46 342 400.0 MK2:500 Type1 None DFGin 4.505 13.916 BLAminus DFGAsp-rot-in -137.86, 175.26 61.96, 98.93 179.47, -53.85 -99.81, 17.41 286.59, 67.21 -44.85, -25.56 in-in in 8.851 Saltbr-in 2.546 HRD-in -66.46, -43.69 66.23, -1.99 in-in-none SNCiin in-none ActLoopNT-in 2.83 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 D 324 269 28 0 0 15 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3E P49137 44 345 400.0 MK2:500 Type1 None DFGin 4.773 13.965 BLAminus DFGAsp-rot-in -128.92, -178.83 60.96, 110.53 187.18, -6.66 -118.06, 18.13 288.23, 69.3 -53.96, -31.23 in-in in 9.094 Saltbr-in 2.496 HRD-in -67.96, -46.81 65.87, -10.72 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -176.66, -15.58 999.0, -104.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 E 324 287 15 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3F P49137 44 350 400.0 MK2:500 Type1 None DFGin 4.917 13.869 BLAminus DFGAsp-rot-in -134.88, 179.04 76.75, 94.93 197.35, -7.71 -104.84, 22.2 282.85, 74.6 -64.74, -17.47 in-in in 8.995 Saltbr-in 2.731 HRD-in -79.49, -56.77 86.68, 2.72 in-in-none SNCiin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.34, 144.53 999.0, 179.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 F 324 293 14 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3H P49137 44 350 400.0 MK2:500 Type1 None DFGin 4.607 13.429 BLAminus DFGAsp-rot-in -138.19, -172.17 57.05, 102.0 200.03, -23.56 -106.68, 27.15 292.81, 72.2 -57.13, -29.31 in-in in 8.726 Saltbr-in 2.696 HRD-in -74.06, -45.37 69.29, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.761 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.73, -8.44 999.0, 98.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 H 324 290 17 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3I P49137 45 356 400.0 MK2:500 Type1 None DFGin 4.689 13.646 BLAminus DFGAsp-rot-in -127.79, 171.26 71.85, 103.11 196.04, -23.06 -106.85, 28.41 284.17, 74.69 -57.35, -27.49 in-in in 8.555 Saltbr-in 2.402 HRD-in -93.72, -30.87 60.32, -1.04 in-in-none SNCiin in-none ActLoopNT-in 2.894 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 I 324 295 17 0 0 13 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3J P49137 43 348 400.0 MK2:500 Type1 None DFGin 4.718 13.802 BLAminus DFGAsp-rot-in -125.72, -175.9 62.46, 84.05 189.07, 7.48 -88.35, 25.1 281.01, 81.77 -82.54, 2.25 in-in in 9.128 Saltbr-in 3.314 HRD-in -78.38, -40.95 69.7, 4.74 in-in-none SNCiin in-none ActLoopNT-in 3.075 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.62, -14.39 999.0, 120.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 J 324 288 18 0 0 9 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3K P49137 44 345 400.0 MK2:500 Type1 None DFGin 4.468 13.615 BLAminus DFGAsp-rot-in -140.04, -177.82 52.3, 117.47 196.4, -0.26 -116.32, 11.78 277.13, 82.36 -69.91, 0.72 in-in in 8.958 Saltbr-in 2.78 HRD-in -74.88, -50.37 73.49, 9.77 in-in-none SNCiin in-none ActLoopNT-in 3.333 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 K 324 280 22 0 0 14 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3L P49137 42 348 400.0 MK2:500 Type1 None DFGin 4.821 13.855 BLAminus DFGAsp-rot-in -130.63, 174.42 78.71, 90.78 191.84, -0.03 -100.08, 26.64 282.13, 65.04 -59.13, -39.73 in-in in 9.255 Saltbr-in 2.663 HRD-in -90.63, -50.0 65.8, 13.75 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.39, -28.9 999.0, 127.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 L 324 291 16 0 0 11 [[63, 325]] 1.0 3kc3 CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPA P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.478 13.85 BLAminus DFGAsp-rot-in -133.98, 174.95 70.89, 89.1 203.2, 12.57 -93.56, 24.83 287.0, 65.27 -55.43, -29.01 in-in in 8.726 Saltbr-in 2.604 HRD-in -85.33, -35.83 65.16, 16.45 in-in-none SNCiin in-none ActLoopNT-in 3.057 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 A 326 283 22 0 0 15 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPB P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.579 13.852 BLAminus DFGAsp-rot-in -138.34, 174.48 73.85, 84.83 201.46, 8.48 -88.84, 30.16 284.72, 60.62 -64.51, -26.86 in-in in 8.707 Saltbr-in 2.535 HRD-in -85.86, -36.04 69.02, 7.05 in-in-none SNCiin in-none ActLoopNT-in 3.061 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -40.26, -29.78 999.0, 121.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 B 326 290 15 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPC P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.503 13.831 BLAminus DFGAsp-rot-in -133.29, -179.58 64.71, 93.56 209.31, 8.58 -95.15, 25.62 283.97, 64.1 -59.22, -26.85 in-in in 8.767 Saltbr-in 2.926 HRD-in -80.25, -42.98 69.55, 17.83 in-in-none SNCiin in-none ActLoopNT-in 3.088 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.2, -7.86 999.0, 175.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 C 326 284 21 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPD P49137 47 350 400.0 P4O:1351 Type1 None DFGin 4.523 13.952 BLAminus DFGAsp-rot-in -137.03, -179.33 64.04, 94.44 196.98, 8.9 -97.23, 21.04 282.65, 66.88 -48.31, -30.44 in-in in 8.832 Saltbr-in 2.714 HRD-in -81.64, -32.5 57.25, 21.38 in-in-none SNCiin in-none ActLoopNT-in 2.967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -148.58, -26.73 999.0, -145.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 D 326 286 18 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPE P49137 44 345 400.0 P4O:1345 Type1 None DFGin 4.724 13.859 BLAminus DFGAsp-rot-in -136.12, 175.35 73.31, 80.12 194.89, 60.07 -82.5, 33.85 283.92, 48.58 -62.96, -45.19 in-in in 8.59 Saltbr-in 2.959 HRD-in -104.14, -29.02 60.75, 18.27 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.62, -21.91 999.0, -152.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 E 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPF P49137 45 350 400.0 P4O:1350 Type1 None DFGin 4.595 13.837 BLAminus DFGAsp-rot-in -132.13, 175.04 70.48, 88.46 202.39, 12.31 -92.2, 24.44 284.08, 67.86 -58.09, -29.79 in-in in 8.685 Saltbr-in 2.569 HRD-in -92.78, -39.0 72.25, 8.97 in-in-none SNCiin in-none ActLoopNT-in 3.082 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -131.16, 4.71 999.0, 165.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 F 326 288 18 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPG P49137 45 350 400.0 P4O:1350 Type1 None DFGin 4.58 13.726 BLAminus DFGAsp-rot-in -138.34, 174.28 71.04, 87.0 198.5, 16.68 -92.84, 24.64 284.29, 71.24 -62.44, -18.91 in-in in 8.739 Saltbr-in 2.523 HRD-in -84.59, -34.64 66.84, 14.57 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.82, -9.25 999.0, -129.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 G 326 288 18 0 0 10 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPH P49137 46 347 400.0 P4O:1347 Type1 None DFGin 4.207 13.746 BLAminus DFGAsp-rot-in -134.88, 173.26 70.14, 89.63 202.03, 14.96 -96.59, 27.77 281.47, 58.87 -55.42, -35.35 in-in in 8.808 Saltbr-in 2.548 HRD-in -90.46, -32.76 68.86, 13.14 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 H 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPI P49137 45 350 400.0 P4O:1351 Type1 None DFGin 4.558 13.813 BLAminus DFGAsp-rot-in -140.96, 171.77 69.8, 89.64 196.66, 15.72 -96.08, 24.27 287.29, 67.6 -46.64, -33.04 in-in in 8.736 Saltbr-in 2.735 HRD-in -89.03, -36.29 66.61, 16.32 in-in-none SNCiin in-none ActLoopNT-in 3.06 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -162.11, 79.7 999.0, -145.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 I 326 289 17 0 0 11 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPK P49137 47 345 400.0 P4O:1345 Type1 None DFGin 4.452 13.779 BLAminus DFGAsp-rot-in -134.43, 174.45 70.58, 87.87 201.71, 8.43 -93.92, 23.8 282.34, 69.99 -55.95, -30.42 in-in in 8.751 Saltbr-in 2.364 HRD-in -80.27, -34.62 66.03, 15.08 in-in-none SNCiin in-none ActLoopNT-in 3.168 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 K 326 265 34 0 0 19 [[63, 325]] 1.0 2jbp CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKA P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.589 13.771 BLAminus DFGAsp-rot-in -126.65, 173.47 71.0, 100.22 207.09, -22.33 -103.09, 25.12 288.21, 68.89 -63.74, -22.07 in-in in 8.808 Saltbr-in 2.833 HRD-in -83.14, -45.68 70.24, 10.29 in-in-none SNCiin in-none ActLoopNT-in 2.999 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 A 334 285 20 0 0 13 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKB P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.574 13.71 BLAminus DFGAsp-rot-in -126.17, 171.53 76.59, 101.21 207.82, -25.8 -106.82, 28.17 283.51, 70.31 -69.3, -20.78 in-in in 8.8 Saltbr-in 2.767 HRD-in -83.32, -42.01 66.8, 9.77 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -76.35, -4.83 999.0, -139.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 B 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKC P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.542 13.708 BLAminus DFGAsp-rot-in -127.95, 171.63 72.32, 100.54 205.09, -21.63 -105.36, 27.99 284.77, 68.66 -70.12, -18.04 in-in in 8.818 Saltbr-in 2.76 HRD-in -83.09, -44.86 72.76, 6.72 in-in-none SNCiin in-none ActLoopNT-in 3.021 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.92, 3.8 999.0, -64.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 C 334 285 20 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKD P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.552 13.762 BLAminus DFGAsp-rot-in -126.6, 170.16 75.93, 99.4 204.42, -25.6 -106.12, 27.5 286.71, 67.62 -64.49, -22.4 in-in in 8.826 Saltbr-in 2.7 HRD-in -78.53, -45.63 70.0, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 D 334 283 22 0 0 15 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKE P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.694 BLAminus DFGAsp-rot-in -126.73, 170.86 73.31, 97.65 204.84, -21.04 -100.72, 25.15 284.53, 70.5 -65.36, -19.29 in-in in 8.823 Saltbr-in 2.816 HRD-in -80.98, -44.08 70.38, 5.75 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -110.91, 12.45 999.0, 143.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 E 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKF P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.474 13.706 BLAminus DFGAsp-rot-in -127.85, 174.17 70.83, 96.56 205.6, -21.22 -99.93, 26.89 286.07, 67.62 -67.09, -18.68 in-in in 8.833 Saltbr-in 2.795 HRD-in -80.56, -45.1 72.92, 6.47 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -140.44, 23.91 999.0, -39.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 F 334 284 21 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKG P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.723 BLAminus DFGAsp-rot-in -127.83, 169.9 76.58, 97.3 205.32, -22.33 -103.07, 31.55 285.98, 70.31 -69.86, -24.12 in-in in 8.832 Saltbr-in 2.773 HRD-in -83.6, -42.88 70.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.958 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.46 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 G 334 286 19 0 0 12 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKH P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.701 BLAminus DFGAsp-rot-in -127.46, 173.5 71.38, 99.68 202.17, -21.32 -106.67, 28.02 284.54, 69.36 -65.15, -20.54 in-in in 8.87 Saltbr-in 2.758 HRD-in -82.45, -44.8 70.18, 5.58 in-in-none SNCiin in-none ActLoopNT-in 2.987 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.35, 40.25 999.0, -116.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 H 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKI P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.446 13.686 BLAminus DFGAsp-rot-in -127.75, 172.18 73.28, 98.61 204.04, -24.2 -103.78, 25.37 284.35, 71.35 -64.93, -20.35 in-in in 8.771 Saltbr-in 2.738 HRD-in -82.7, -44.15 67.61, 9.58 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -120.54, 0.33 999.0, -77.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 I 334 284 21 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKJ P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.516 13.696 BLAminus DFGAsp-rot-in -125.94, 171.03 73.59, 99.21 206.78, -25.19 -101.22, 24.36 288.17, 72.78 -63.96, -20.62 in-in in 8.837 Saltbr-in 2.841 HRD-in -84.33, -42.62 69.41, 8.71 in-in-none SNCiin in-none ActLoopNT-in 3.076 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 J 334 283 22 0 0 15 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKK P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.495 13.74 BLAminus DFGAsp-rot-in -127.59, 167.14 77.13, 99.42 204.63, -20.86 -103.98, 27.43 284.8, 74.73 -67.14, -17.07 in-in in 8.865 Saltbr-in 2.825 HRD-in -83.96, -44.73 69.47, 7.73 in-in-none SNCiin in-none ActLoopNT-in 3.043 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.78, -37.53 999.0, -135.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 K 334 290 15 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKL P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.548 13.687 BLAminus DFGAsp-rot-in -128.35, 173.4 71.1, 97.91 205.12, -19.81 -103.12, 25.34 286.16, 67.54 -60.79, -25.02 in-in in 8.821 Saltbr-in 2.744 HRD-in -84.04, -41.11 66.0, 8.07 in-in-none SNCiin in-none ActLoopNT-in 3.03 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -106.57, 23.19 999.0, 177.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 L 334 284 21 0 0 11 [[63, 325]] 1.0 3gok CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KA0A P49137 47 364 400.0 MK3:500 Type1 None DFGin 4.835 13.747 BLAminus DFGAsp-rot-in -134.09, 176.23 64.42, 97.77 191.49, -18.84 -108.27, 26.09 291.3, 65.21 -54.85, -29.31 in-in in 9.224 Saltbr-in 2.84 HRD-in -80.5, -45.65 65.5, 4.98 in-in-none SNCiin in-none ActLoopNT-in 2.817 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E None None XRAY 2.9 0.232 0.265 A 320 279 39 0 0 19 [[63, 325]] 1.0 3ka0 CAMK_MAPKAPK2_HUMAN CAMK 7.9e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA P49137 42 345 400.0 STU:401 Type1 None DFGin 4.829 13.428 BLAminus DFGAsp-rot-in -122.05, -170.73 42.15, 101.84 213.94, -26.7 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.716 Saltbr-in 2.473 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.683 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400 290 14 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.9e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB P49137 44 345 400.0 STU:403 Type1 None DFGin 4.577 13.822 BLAminus DFGAsp-rot-in -128.27, 177.79 53.09, 103.0 212.26, -27.79 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.647 Saltbr-in 2.563 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.82 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400 283 19 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.9e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC P49137 41 357 400.0 STU:401 Type1 None DFGin 4.963 13.774 BLAminus DFGAsp-rot-in -132.89, 178.15 57.47, 93.76 215.49, -32.36 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.684 Saltbr-in 2.34 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400 306 11 0 0 11 [[63, 325]] 1.0 1nxk CAMK_MAPKAPK2_HUMAN CAMK 6.9e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KGAA P49137 47 364 400.0 LX9:365 Type1 None DFGin 4.446 13.678 BLAminus DFGAsp-rot-in -124.87, 174.18 69.13, 92.77 202.49, -31.06 -95.92, 21.23 282.6, 67.95 -62.32, -18.3 in-in in 8.84 Saltbr-in 2.692 HRD-in -73.16, -55.01 73.82, 13.46 in-in-none SNCiin in-none ActLoopNT-in 3.001 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.55 0.183 0.235 A 299 290 7 0 0 0 [[63, 325]] 1.0 3kga CAMK_MAPKAPK2_HUMAN CAMK 2e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3M2WA P49137 47 364 400.0 L8I:1 Type1 None DFGin 4.422 13.673 BLAminus DFGAsp-rot-in -122.16, 170.83 75.18, 88.88 204.51, -16.96 -90.88, 16.66 279.1, 67.47 -57.47, -17.13 in-in in 8.951 Saltbr-in 2.544 HRD-in -74.98, -51.41 69.8, 12.51 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.41 0.187 0.227 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m2w CAMK_MAPKAPK2_HUMAN CAMK 2e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A P49137 47 364 400.0 HGF:365 Type1 None DFGin 4.265 13.765 BLAminus DFGAsp-rot-in -127.28, 170.7 71.87, 101.44 197.54, -33.53 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.26 Saltbr-in 3.091 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m42 CAMK_MAPKAPK2_HUMAN CAMK 2e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 6T8XB P49137 45 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.499 13.631 BLAminus DFGAsp-rot-in -129.76, 174.11 63.68, 95.47 216.99, -29.23 -98.99, 32.39 289.86, 73.64 -62.73, -29.4 in-in in 8.644 Saltbr-in 2.799 HRD-in -70.3, -40.77 63.38, 5.93 in-in-none SNCiin in-none ActLoopNT-in 2.983 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.94 APE8-rot-in 320.74 APE67-dihe-in -57.79, -34.07 -54.58, -48.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 B 319 276 9 0 0 9 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.8e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 6T8XC P49137 44 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.542 13.623 BLAminus DFGAsp-rot-in -130.94, 173.46 63.89, 94.6 218.75, -29.08 -98.12, 31.68 290.58, 73.54 -62.98, -29.52 in-in in 8.608 Saltbr-in 2.836 HRD-in -74.07, -44.94 68.64, 5.14 in-in-none SNCiin in-none ActLoopNT-in 2.985 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.58 APE8-rot-in 319.09 APE67-dihe-in -57.21, -34.86 -54.2, -47.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 C 319 276 10 0 0 10 [[63, 325]] 1.0 6t8x CAMK_MAPKAPK2_HUMAN CAMK 7.8e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK3 MAPK3_HUMAN 3R1NA Q16644 33 348 382.0 05B:1 Type1 None DFGin 4.896 13.723 BLAminus DFGAsp-rot-in -136.67, 172.77 78.51, 90.83 198.42, -17.05 -101.61, 24.05 288.26, 79.22 -63.01, -24.62 in-in in 8.725 Saltbr-in 2.828 HRD-in -78.68, -50.93 70.53, 6.79 in-in-none SNCiin in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.216 0.258 A 317 274 42 0 0 17 [[43, 304]] 1.0 3r1n CAMK_MAPKAPK3_HUMAN CAMK 6.4e-79 270.9 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 3SHEA Q16644 33 348 382.0 I85:350 Type1 None DFGin 5.064 13.713 BLAminus DFGAsp-rot-in -121.04, 179.13 78.75, 86.24 204.72, -17.65 -103.12, 28.39 293.82, 81.07 -68.69, -16.03 in-in in 8.803 Saltbr-in 2.712 HRD-in -78.85, -52.74 72.19, 13.35 in-in-none SNCiin in-none ActLoopNT-in 2.961 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.248 0.271 A 317 270 46 0 0 18 [[43, 304]] 1.0 3she CAMK_MAPKAPK3_HUMAN CAMK 6.4e-79 270.9 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 3FHRA Q16644 33 349 382.0 P4O:1 Type1 None DFGin 4.699 13.823 BLAminus DFGAsp-rot-in -141.35, -177.59 72.02, 91.12 192.61, -9.61 -99.99, 27.14 290.18, 82.64 -72.4, -18.76 in-in in 8.535 Saltbr-in 2.724 HRD-in -82.05, -51.65 76.12, 7.07 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.228 0.267 A 336 273 44 0 0 18 [[43, 304]] 1.0 3fhr CAMK_MAPKAPK3_HUMAN CAMK 7.8e-79 270.6 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 3FXWA Q16644 33 349 382.0 F10:1 Type1 None DFGin 4.695 13.736 BLAminus DFGAsp-rot-in -136.8, -179.26 78.7, 91.06 188.52, -6.3 -98.97, 26.29 291.45, 74.65 -64.27, -27.51 in-in in 8.569 Saltbr-in 2.597 HRD-in -87.39, -52.65 79.46, 4.69 in-in-none SNCiin in-none ActLoopNT-in 2.842 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.235 0.277 A 336 271 46 0 0 19 [[43, 304]] 1.0 3fxw CAMK_MAPKAPK3_HUMAN CAMK 7.8e-79 270.6 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 7NRBA Q16644 33 349 382.0 P4O:401 Type1 None DFGin 4.627 13.783 BLAminus DFGAsp-rot-in -148.65, -177.31 69.63, 94.52 195.71, -16.78 -103.08, 30.24 293.93, 81.96 -68.85, -25.17 in-in in 8.511 Saltbr-in 2.629 HRD-in -79.95, -52.31 74.88, 5.61 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.214 0.235 A 336 273 44 0 0 18 [[43, 304]] 1.0 7nrb CAMK_MAPKAPK3_HUMAN CAMK 7.8e-79 270.6 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MELK MELK_HUMAN 5IH8A Q14680 3 327 651.0 6BJ:60401 Type1 None DFGin 6.899 15.015 BLAminus DFGAsp-rot-in -123.97, 176.03 57.35, 81.53 200.37, -10.26 -98.01, 22.13 281.32, 75.72 -67.27, -27.19 in-in in 8.68 Saltbr-in 2.708 HRD-in -68.78, -51.48 74.83, -1.98 in-in-none SNCiin in-none ActLoopNT-in 2.925 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -5.67 APE8-rot-in 289.51 APE67-dihe-in -61.1, -22.21 -55.23, -38.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.178 0.2 A 335 305 20 0 0 14 [[11, 263]] 1.0 5ih8 CAMK_MELK_HUMAN CAMK 1e-88 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.939 15.146 BLAminus DFGAsp-rot-in -123.48, 176.08 58.26, 79.91 204.43, -22.81 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.72 Saltbr-in 2.587 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335 307 18 0 0 14 [[11, 263]] 1.0 5ih9 CAMK_MELK_HUMAN CAMK 1e-88 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 5IHAA Q14680 3 327 651.0 6BE:60401 Type1 None DFGin 6.829 15.042 BLAminus DFGAsp-rot-in -120.87, 177.4 55.95, 85.64 206.84, -17.74 -102.14, 23.45 281.65, 80.18 -67.54, -28.51 in-in in 8.842 Saltbr-in 2.632 HRD-in -71.43, -49.46 70.45, 4.23 in-in-none SNCiin in-none ActLoopNT-in 3.034 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.72 APE8-rot-in 296.55 APE67-dihe-in -57.19, -26.87 -59.91, -43.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.175 0.202 A 335 302 23 0 0 14 [[11, 263]] 1.0 5iha CAMK_MELK_HUMAN CAMK 1e-88 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 6GVXA Q14680 1 333 651.0 TAK:60402 Type1 None DFGin 6.711 15.26 BLAminus DFGAsp-rot-in -125.4, 178.58 58.73, 78.31 202.87, -15.61 -98.95, 27.88 285.76, 76.62 -69.49, -24.6 in-in in 9.004 Saltbr-in 2.908 HRD-in -62.31, -45.72 65.24, 14.32 in-in-none SNCiin in-none ActLoopNT-in 2.869 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -86.88 APE9-dihe-na -85.92, -154.54 APE8-dihe-in -73.43, 134.24 APE8-rot-in 297.0 APE67-dihe-in -62.55, -20.46 -61.75, -38.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.519 APE9-dist-in 4.486 None None None XRAY 2.24 0.205 0.24 A 344 311 15 0 0 7 [[11, 263]] 1.0 6gvx CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4BKYA Q14680 3 333 651.0 82B:1334 Type1 None DFGin 6.861 14.789 BLAminus DFGAsp-rot-in -126.95, 173.05 62.71, 72.79 206.89, -23.31 -92.87, 16.6 286.13, 76.41 -58.61, -28.78 in-in in 8.592 Saltbr-in 2.597 HRD-in -70.13, -52.15 72.52, 2.08 in-in-none SNCiin in-none ActLoopNT-in 3.012 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -30.73 APE8-rot-in 283.32 APE67-dihe-in -55.55, -24.59 -55.8, -42.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.83 0.204 0.223 A 347 311 20 0 0 15 [[11, 263]] 1.0 4bky CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2TB Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.517 15.482 BLAminus DFGAsp-rot-in -134.63, -178.27 55.46, 74.9 201.32, 12.32 -94.29, 23.67 286.62, 83.25 -66.74, -35.72 in-in in 9.149 Saltbr-in 2.788 HRD-in -58.96, -48.62 71.55, 4.62 in-in-none SNCiin in-none ActLoopNT-in 2.809 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -118.25 APE9-dihe-na 126.7, -132.88 APE8-dihe-in -115.61, 136.66 APE8-rot-none 999.0 APE67-dihe-in -51.25, -29.04 -60.65, -47.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.181 APE9-dist-in 3.724 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 B 356 322 11 0 0 6 [[11, 263]] 1.0 4d2t CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2TC Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.63 15.594 BLAminus DFGAsp-rot-in -134.25, 179.33 57.66, 74.82 201.0, 12.54 -93.87, 24.92 285.83, 82.78 -70.22, -25.26 in-in in 9.153 Saltbr-in 2.796 HRD-in -57.46, -50.13 71.26, 4.63 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -131.47 APE8-dihe-in -117.46, 135.5 APE8-rot-none 999.0 APE67-dihe-in -52.13, -27.45 -60.57, -47.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.685 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 C 356 313 20 0 0 13 [[11, 263]] 1.0 4d2t CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2TD Q14680 3 333 651.0 3I7:61334 Type1 None DFGin 6.495 15.537 BLAminus DFGAsp-rot-in -130.9, 164.85 58.81, 83.3 212.3, -5.47 -99.74, 25.07 285.57, 83.05 -62.72, -39.18 in-in in 9.267 Saltbr-in 2.798 HRD-in -58.57, -49.69 71.95, 4.52 in-in-none SNCiin in-none ActLoopNT-in 2.797 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -132.43 APE8-dihe-in -116.12, 138.43 APE8-rot-none 999.0 APE67-dihe-in -52.16, -28.22 -60.64, -47.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.733 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 D 356 319 8 0 0 8 [[11, 263]] 1.0 4d2t CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2VA Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.792 15.704 BLAminus DFGAsp-rot-in -128.16, -178.54 46.67, 81.9 183.92, 40.77 -94.66, 26.37 289.35, 79.84 -48.93, -31.86 in-in in 9.388 Saltbr-in 2.87 HRD-in -64.57, -46.97 77.06, -5.55 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.0 APE8-dihe-in -89.53, 134.8 APE8-rot-none 999.0 APE67-dihe-in -53.64, -18.08 -71.01, -44.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.591 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 A 356 312 21 0 0 15 [[11, 263]] 1.0 4d2v CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2VC Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.773 15.768 BLAminus DFGAsp-rot-in -127.7, -179.29 47.99, 81.71 183.86, 42.38 -95.83, 24.05 288.88, 80.0 -69.4, -23.25 in-in in 9.391 Saltbr-in 2.866 HRD-in -64.65, -48.16 76.02, -3.72 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -147.18 APE8-dihe-in -89.76, 137.08 APE8-rot-none 999.0 APE67-dihe-in -54.65, -16.89 -71.35, -44.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.61 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 C 356 316 17 0 0 13 [[11, 263]] 1.0 4d2v CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2VD Q14680 3 333 651.0 45R:61334 Type1 None DFGin 6.757 15.657 BLAminus DFGAsp-rot-in -128.1, -177.36 48.27, 80.83 184.73, 41.85 -95.04, 26.93 289.26, 79.87 -56.22, -36.0 in-in in 9.438 Saltbr-in 2.847 HRD-in -64.33, -48.39 77.06, -3.92 in-in-none SNCiin in-none ActLoopNT-in 3.383 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.49 APE8-dihe-in -88.59, 137.31 APE8-rot-none 999.0 APE67-dihe-in -54.66, -16.96 -72.15, -45.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.648 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 D 356 318 8 0 0 8 [[11, 263]] 1.0 4d2v CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2WC Q14680 1 333 651.0 NF5:1334 Type1 None DFGin 6.857 15.642 BLAminus DFGAsp-rot-in -123.79, 178.59 60.65, 71.55 200.51, -15.56 -90.39, 19.57 282.34, 80.84 -69.3, -20.74 in-in in 8.998 Saltbr-in 2.743 HRD-in -74.38, -48.87 73.02, -0.95 in-in-none SNCiin in-none ActLoopNT-in 3.019 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.96 APE8-dihe-in -49.29, 128.09 APE8-rot-none 999.0 APE67-dihe-in -59.65, -22.66 -56.52, -44.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.747 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 C 356 313 20 0 0 13 [[11, 263]] 1.0 4d2w CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMPD Q14680 2 333 651.0 5QM:1334 Type1 None DFGin 6.868 15.538 BLAminus DFGAsp-rot-in -128.98, 172.85 60.45, 81.99 201.17, -28.33 -100.97, 13.83 278.54, 87.38 -58.85, -32.32 in-in in 9.123 Saltbr-in 2.758 HRD-in -66.2, -47.15 69.3, -6.44 in-in-none SNCiin in-none ActLoopNT-in 2.885 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.38 APE8-dihe-in -63.2, 133.11 APE8-rot-none 999.0 APE67-dihe-in -59.09, -26.16 -63.77, -40.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.238 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 D 356 321 7 0 0 7 [[11, 263]] 1.0 4ump CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PA Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.767 15.436 BLAminus DFGAsp-rot-in -121.57, -178.43 43.06, 87.01 184.42, 58.42 -96.75, 36.15 287.09, 78.41 -62.79, -28.68 in-in in 9.863 Saltbr-in 3.489 HRD-in -65.09, -43.36 70.33, -2.48 in-in-none SNCiin in-none ActLoopNT-in 3.474 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.47 APE8-dihe-in -63.07, 132.76 APE8-rot-none 999.0 APE67-dihe-in -56.46, -25.28 -62.72, -43.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.13 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 A 356 313 20 0 0 14 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PB Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.804 15.267 BLAminus DFGAsp-rot-in -116.15, -179.55 42.83, 87.18 181.89, 58.54 -95.49, 33.61 286.93, 77.41 -73.57, -28.71 in-in in 9.691 Saltbr-in 3.386 HRD-in -66.38, -43.95 69.75, -0.06 in-in-none SNCiin in-none ActLoopNT-in 3.155 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -89.14 APE9-dihe-na 110.05, -162.04 APE8-dihe-in -67.8, 135.44 APE8-rot-none 999.0 APE67-dihe-in -55.82, -25.74 -63.48, -45.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.356 APE9-dist-in 4.242 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 B 356 323 10 0 0 6 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PC Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.77 15.235 BLAminus DFGAsp-rot-in -121.44, -178.21 43.87, 86.48 182.86, 59.76 -97.16, 31.68 287.92, 77.16 -71.21, -25.62 in-in in 9.58 Saltbr-in 3.254 HRD-in -64.88, -44.62 70.79, 0.06 in-in-none SNCiin in-none ActLoopNT-in 2.868 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.51 APE8-dihe-in -65.31, 136.43 APE8-rot-none 999.0 APE67-dihe-in -56.72, -24.92 -63.56, -46.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 C 356 315 18 0 0 13 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PD Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.778 15.262 BLAminus DFGAsp-rot-in -121.01, -179.74 44.13, 87.06 183.13, 57.86 -96.7, 34.13 287.58, 76.33 -72.88, -28.13 in-in in 9.882 Saltbr-in 3.47 HRD-in -66.46, -43.59 69.94, 0.8 in-in-none SNCiin in-none ActLoopNT-in 3.091 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.68 APE8-dihe-in -65.17, 134.89 APE8-rot-none 999.0 APE67-dihe-in -55.96, -25.2 -65.21, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.206 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 D 356 317 7 0 0 7 [[11, 263]] 1.0 4d2p CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMPA Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.778 15.294 BLAminus DFGAsp-rot-in -116.7, -176.8 54.54, 81.11 206.62, -29.43 -105.57, 22.84 278.1, 82.0 -64.7, -26.81 in-in in 9.187 Saltbr-in 2.741 HRD-in -68.68, -33.57 59.29, 16.14 in-in-none SNCiin in-none ActLoopNT-in 3.404 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.18 APE8-dihe-in -64.9, 131.94 APE8-rot-none 999.0 APE67-dihe-in -58.2, -28.41 -61.43, -40.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.989 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 A 356 313 20 0 0 14 [[11, 263]] 1.0 4ump CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMPC Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.803 15.543 BLAminus DFGAsp-rot-in -123.91, -179.28 56.39, 85.45 196.81, -31.0 -103.47, 13.92 280.5, 85.56 -60.17, -35.76 in-in in 9.051 Saltbr-in 2.737 HRD-in -71.35, -45.77 70.39, -10.7 in-in-none SNCiin in-none ActLoopNT-in 2.907 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.15 APE8-dihe-in -66.96, 131.15 APE8-rot-none 999.0 APE67-dihe-in -60.1, -27.83 -60.42, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.587 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 C 356 311 22 0 0 13 [[11, 263]] 1.0 4ump CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM2 PIM2_HUMAN 2IWIA Q9P1W9 32 288 311.0 HB1:1289 Type1 None DFGin 6.219 14.218 BLAminus DFGAsp-rot-in -110.81, 164.83 68.74, 90.42 191.03, -13.99 -99.66, 29.13 287.09, 66.88 -61.46, -39.74 in-none in 8.56 Saltbr-none 999.0 HRD-na-T -76.62, -35.93 58.51, 10.21 none-in-in SNCnii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.36, -16.65 APE9-dihe-na -63.74, 173.12 APE8-dihe-in -77.0, 156.24 APE8-rot-in 263.75 APE67-dihe-in -52.18, -29.37 -50.11, -60.45 APE12-dist-in 9.015 APE11-dist-in 9.245 APE10-dist-in 4.898 APE9-dist-in 5.68 None None None XRAY 2.8 0.244 0.289 A 312 244 13 0 0 0 [[32, 286]] 1.0 2iwi CAMK_PIM2_HUMAN CAMK 5.7e-61 212.0 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK PIM2 PIM2_HUMAN 2IWIB Q9P1W9 22 287 311.0 HB1:1288 Type1 None DFGin 6.13 13.843 BLAminus DFGAsp-rot-in -118.57, 161.53 68.46, 93.4 199.54, -29.82 -100.16, 25.47 292.3, 69.44 -61.98, -35.07 in-none in 8.602 Saltbr-none 999.0 HRD-na-T -73.52, -38.58 59.85, 10.52 none-in-in SNCnii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -94.66, -16.48 APE9-dihe-na -63.71, 174.13 APE8-dihe-in -79.54, 156.69 APE8-rot-in 292.9 APE67-dihe-in -51.11, -31.79 -54.32, -53.14 APE12-dist-in 8.851 APE11-dist-in 9.327 APE10-dist-in 4.895 APE9-dist-in 5.671 None None None XRAY 2.8 0.244 0.289 B 312 249 17 0 0 0 [[32, 286]] 1.0 2iwi CAMK_PIM2_HUMAN CAMK 5.7e-61 212.0 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK PIM2 PIM2_HUMAN 4X7QA Q9P1W9 32 287 311.0 3YR:401 Type1 None DFGin 6.467 14.664 BLAminus DFGAsp-rot-in -126.1, 165.99 65.04, 79.85 197.65, 17.52 -95.42, 6.54 281.8, 81.22 -72.84, 17.13 in-in in 8.3 Saltbr-in 2.568 HRD-na-T -75.97, -46.2 69.29, -4.22 in-in-none SNCiin in-none ActLoopNT-in 3.014 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 21.71 APE9-dihe-na -87.64, 176.68 APE8-dihe-in -77.74, 129.43 APE8-rot-in 298.56 APE67-dihe-in -70.69, -7.37 -67.84, -36.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.25 APE9-dist-in 4.16 None None None XRAY 2.33 0.199 0.258 A 312 217 39 0 0 10 [[32, 286]] 1.0 4x7q CAMK_PIM2_HUMAN CAMK 5.7e-61 212.0 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.469 14.143 BLAminus DFGAsp-rot-in -120.9, 173.77 65.89, 86.51 190.94, 16.64 -96.46, 22.04 287.59, 69.84 -51.57, -39.89 in-in in 8.867 Saltbr-in 2.809 HRD-in -86.24, -52.51 73.21, 10.94 in-in-none SNCiin in-none ActLoopNT-in 2.989 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 A 325 282 33 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.769 14.211 BLAminus DFGAsp-rot-in -127.01, 177.83 61.12, 80.37 199.4, -13.68 -96.03, 24.29 287.04, 69.05 -65.01, -20.75 in-in in 8.872 Saltbr-in 2.738 HRD-in -80.02, -49.37 72.67, 1.66 in-in-none SNCiin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 B 325 289 26 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN6A O75582 415 729 802.0 No_ligand No_ligand None DFGin 5.611 14.26 BLAminus DFGAsp-rot-in -118.28, 175.46 61.9, 79.38 196.64, -1.73 -91.95, 22.39 287.08, 72.16 -57.81, -30.08 in-in in 8.55 Saltbr-in 2.631 HRD-in -82.27, -48.41 76.43, -4.89 in-in-none SNCiin in-none ActLoopNT-in 2.9 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.219 0.263 A 325 282 33 0 0 18 [[49, 318], [423, 687]] 2.0 3kn6 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN6B O75582 415 729 802.0 No_ligand No_ligand None DFGin 5.71 14.3 BLAminus DFGAsp-rot-in -116.55, 177.27 57.59, 82.82 198.62, -5.64 -93.95, 22.75 286.03, 67.47 -63.56, -27.92 in-in in 8.613 Saltbr-in 2.634 HRD-in -79.95, -51.48 73.92, -1.2 in-in-none SNCiin in-none ActLoopNT-in 2.946 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.219 0.263 B 325 288 27 0 0 18 [[49, 318], [423, 687]] 2.0 3kn6 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP4A O75582 415 723 802.0 O1K:60900 Type1 None DFGin 5.474 14.593 BLAminus DFGAsp-rot-in -122.74, 179.98 59.98, 77.55 205.02, -32.94 -82.97, 36.44 285.0, 70.28 -65.72, -47.91 in-in in 8.387 Saltbr-in 2.923 HRD-in -87.02, -45.05 64.57, 8.0 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.198 0.271 A 306 273 16 0 0 0 [[49, 318], [423, 687]] 2.0 7up4 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP4B O75582 415 728 802.0 O1K:60900 Type1 None DFGin 5.701 14.66 BLAminus DFGAsp-rot-in -127.03, -172.02 45.7, 88.1 195.42, 16.34 -96.74, 28.49 286.1, 79.63 -64.65, -32.76 in-in in 8.434 Saltbr-in 2.835 HRD-in -85.31, -45.96 68.72, 10.44 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.198 0.271 B 306 286 8 0 0 0 [[49, 318], [423, 687]] 2.0 7up4 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP5A O75582 415 723 802.0 O1R:60901 Type1 None DFGin 5.664 14.714 BLAminus DFGAsp-rot-in -122.63, -178.53 60.51, 88.42 188.78, 66.22 -101.56, 29.57 282.99, 77.86 -68.32, -33.69 in-in in 8.538 Saltbr-in 3.114 HRD-in -71.92, -47.31 60.46, 18.29 in-in-none SNCiin in-none ActLoopNT-in 2.798 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.208 0.268 A 306 275 14 0 0 0 [[49, 318], [423, 687]] 2.0 7up5 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP5B O75582 415 728 802.0 O1R:60901 Type1 None DFGin 5.781 14.616 BLAminus DFGAsp-rot-in -124.33, -175.52 59.67, 87.86 192.53, 10.39 -104.08, 30.8 286.5, 78.36 -71.29, -27.63 in-in in 8.485 Saltbr-in 2.974 HRD-in -73.09, -49.84 65.25, 16.76 in-in-none SNCiin in-none ActLoopNT-in 2.978 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.208 0.268 B 306 286 8 0 0 0 [[49, 318], [423, 687]] 2.0 7up5 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP7A O75582 415 725 802.0 1LE:60900 Type1 None DFGin 5.591 14.211 BLAminus DFGAsp-rot-in -125.22, 177.51 60.32, 85.8 198.11, 5.63 -95.44, 29.21 285.45, 74.04 -73.73, -22.53 in-in in 8.422 Saltbr-in 2.746 HRD-in -73.08, -52.28 71.87, 3.1 in-in-none SNCiin in-none ActLoopNT-in 3.141 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.188 0.244 A 306 277 11 0 0 0 [[49, 318], [423, 687]] 2.0 7up7 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP7B O75582 416 728 802.0 1LE:60900 Type1 None DFGin 5.652 14.149 BLAminus DFGAsp-rot-in -125.82, 177.98 60.43, 85.41 197.06, 5.16 -97.8, 28.34 286.39, 74.01 -73.9, -22.32 in-in in 8.511 Saltbr-in 2.727 HRD-in -73.39, -51.12 72.22, 2.73 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.188 0.244 B 306 280 10 0 0 0 [[49, 318], [423, 687]] 2.0 7up7 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP8A O75582 415 723 802.0 O10:60900 Type1 None DFGin 5.47 14.555 BLAminus DFGAsp-rot-in -126.38, -176.54 57.89, 82.8 195.96, -2.69 -93.17, 31.16 285.14, 65.13 -71.78, -14.66 in-in in 8.658 Saltbr-in 3.008 HRD-in -69.8, -58.15 74.74, 5.63 in-in-none SNCiin in-none ActLoopNT-in 3.121 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.194 0.263 A 306 273 16 0 0 0 [[49, 318], [423, 687]] 2.0 7up8 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP8B O75582 415 727 802.0 O10:60900 Type1 None DFGin 5.691 14.48 BLAminus DFGAsp-rot-in -127.35, -177.88 56.29, 83.72 198.2, -2.2 -95.23, 31.38 286.27, 65.22 -70.45, -14.23 in-in in 8.552 Saltbr-in 2.901 HRD-in -70.46, -59.48 76.49, 5.89 in-in-none SNCiin in-none ActLoopNT-in 3.08 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.194 0.263 B 306 280 13 0 0 0 [[49, 318], [423, 687]] 2.0 7up8 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP6A O75582 416 707 802.0 SUU:60900,OXM:60901,OXM:60902 Type1,Allosteric,Allosteric None DFGin 5.591 13.8 BLAminus DFGAsp-rot-in -126.35, 175.79 57.79, 81.54 203.23, -3.48 -83.37, 27.18 291.21, 78.77 -62.37, -28.83 in-in in 8.371 Saltbr-in 2.52 HRD-in -72.11, -52.65 71.73, 7.94 in-in-none SNCiin in-none ActLoopNT-in 2.853 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.17 0.209 A 306 256 13 0 0 0 [[49, 318], [423, 687]] 2.0 7up6 CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK STK17B ST17B_HUMAN 7Q7CA O94768 25 297 372.0 ADP:60402 ATPlike None DFGin 5.672 13.983 BLAminus DFGAsp-rot-in -146.28, 174.77 69.66, 80.54 200.88, -18.05 -103.01, 24.61 291.62, 86.01 -65.04, -13.43 in-in in 9.403 Saltbr-in 3.35 HRD-in -84.64, -49.74 76.32, -16.47 in-in-none SNCiin in-none ActLoopNT-in 3.297 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.13 APE8-rot-in 309.53 APE67-dihe-in -65.37, -16.14 -54.33, -43.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.21 0.238 A 327 265 8 0 0 8 [[32, 293]] 1.0 7q7c CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 CSNK1A1 KC1A_HUMAN 8G66F P48729 10 303 337.0 No_ligand No_ligand None DFGin 6.691 14.706 BLAminus DFGAsp-rot-in -136.03, -174.06 61.85, 69.19 185.42, -2.63 -78.04, 10.68 292.24, 95.4 -51.34, -23.46 in-in in 7.682 Saltbr-in 3.377 HRD-in -83.58, -49.33 62.86, 12.64 in-in-none SNCiin in-none ActLoopNT-in 2.983 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -102.78, 114.36 APE9-dihe-na 120.82, 175.64 APE8-dihe-in -62.9, 131.79 APE8-rot-none 999.0 APE67-dihe-in -50.33, -44.66 -60.52, -40.89 APE12-dist-in 12.958 APE11-dist-in 11.933 APE10-dist-in 6.404 APE9-dist-in 3.831 None None None XRAY 3.45 0.215 0.272 F 341 294 0 0 0 0 [[17, 283]] 1.0 8g66 CK1_CSNK1A1_HUMAN CK1 2.8e-121 409.9 1 261 261 156 157 158 160 162 46 60 64 133 135 134 136 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha
CK1 CSNK1D KC1D_HUMAN 6RU6B P48730 3 294 415.0 ACP:60301 ATPlike None DFGin 6.59 15.156 BLAminus DFGAsp-rot-in -129.63, 177.25 73.9, 71.28 198.6, 0.34 -92.31, 21.27 283.76, 74.29 -58.84, -31.38 in-in in 7.818 Saltbr-in 2.796 HRD-in -76.32, -55.32 74.02, 14.82 in-in-none SNCiin in-none ActLoopNT-in 2.86 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.17 APE8-dihe-in -104.51, 127.76 APE8-rot-in 311.88 APE67-dihe-in -57.59, -35.09 -58.93, -44.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.941 None None None XRAY 2.05 0.213 0.257 B 296 278 14 0 0 8 [[9, 275]] 1.0 6ru6 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 3UYTD P48730 4 294 415.0 0CK:295 Type1 None DFGin 6.058 14.902 BLAminus DFGAsp-rot-in -125.11, 171.89 69.6, 107.56 220.41, -55.79 -115.59, 22.0 279.81, 112.96 -71.13, -36.34 in-in in 8.444 Saltbr-in 3.03 HRD-in -87.06, -44.31 72.64, -9.74 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 157.15 APE9-dihe-na 110.54, 179.72 APE8-dihe-in -77.04, 125.8 APE8-rot-in 336.84 APE67-dihe-in -54.65, -24.61 -55.67, -34.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.132 APE9-dist-in 4.59 None None None XRAY 2.0 0.244 0.264 D 296 268 23 0 0 16 [[9, 275]] 1.0 3uyt CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 5OKTB P48730 4 294 415.0 9XK:301 Type1 None DFGin 6.127 14.635 BLAminus DFGAsp-rot-in -133.48, 170.79 70.83, 88.65 206.05, -38.56 -98.93, 18.4 294.6, 95.75 -62.62, -31.39 in-in in 7.966 Saltbr-in 2.832 HRD-in -78.04, -48.78 74.52, -0.37 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -70.45 APE9-dihe-na -87.34, -162.07 APE8-dihe-in -74.91, 135.72 APE8-rot-in 311.98 APE67-dihe-in -57.97, -40.98 -67.96, -35.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.351 APE9-dist-in 3.835 None TPO220 TPO220 XRAY 2.13 0.194 0.221 B 314 282 9 0 0 9 [[9, 275]] 1.0 5okt CK1_CSNK1D_HUMAN CK1 2e-122 413.6 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7NZYB P48730 2 294 415.0 UX2:301 Type1 None DFGin 6.558 14.882 BLAminus DFGAsp-rot-in -133.2, 168.2 69.93, 96.11 199.68, -46.4 -104.78, 25.32 292.5, 81.62 -64.88, -24.78 in-in in 8.136 Saltbr-in 2.965 HRD-in -79.22, -50.76 76.11, 7.31 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.52, -73.6 APE9-dihe-na -68.02, -150.38 APE8-dihe-in -91.32, 139.07 APE8-rot-in 311.34 APE67-dihe-in -57.14, -39.91 -68.37, -36.29 APE12-dist-none 999.0 APE11-dist-in 11.813 APE10-dist-in 6.872 APE9-dist-in 3.731 None TPO220 TPO220 XRAY 1.85 0.205 0.229 B 314 286 7 0 0 7 [[9, 275]] 1.0 7nzy CK1_CSNK1D_HUMAN CK1 2e-122 413.6 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 4KB8A P48730 3 293 415.0 1QN:401 Type1 None DFGin 5.98 14.795 BLAminus DFGAsp-rot-in -126.76, 172.83 67.65, 98.79 214.37, -58.5 -108.65, 18.05 291.14, 100.67 -60.78, -33.86 in-in in 8.264 Saltbr-in 2.885 HRD-in -74.47, -48.24 76.4, -6.59 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.46 APE8-dihe-in -103.07, 128.56 APE8-rot-in 304.05 APE67-dihe-in -56.21, -39.45 -54.48, -41.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.597 None None None XRAY 1.95 0.207 0.232 A 331 265 26 0 0 18 [[9, 275]] 1.0 4kb8 CK1_CSNK1D_HUMAN CK1 2.4e-122 413.4 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 4KBAA P48730 3 293 415.0 1QM:401 Type1 None DFGin 5.942 14.713 BLAminus DFGAsp-rot-in -128.03, 172.49 65.02, 105.13 210.65, -54.47 -114.85, 19.06 291.3, 105.5 -62.25, -33.76 in-in in 8.12 Saltbr-in 2.814 HRD-in -73.17, -51.42 78.43, -6.31 in-in-none SNCiin in-none ActLoopNT-in 2.918 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.81 APE8-dihe-in -100.61, 126.43 APE8-rot-in 305.06 APE67-dihe-in -59.74, -39.86 -55.88, -36.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.561 None None None XRAY 1.98 0.21 0.237 A 331 263 28 0 0 18 [[9, 275]] 1.0 4kba CK1_CSNK1D_HUMAN CK1 2.4e-122 413.4 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1G1 KC1G1_HUMAN 2CMWA Q9HCP0 44 339 422.0 OLP:1340,OLP:1341,OLP:1342 Type1,Allosteric,Allosteric None DFGin 6.558 15.115 BLAminus DFGAsp-rot-in -129.0, 174.5 61.96, 82.76 201.36, -13.18 -97.59, 18.98 283.72, 87.15 -61.89, -30.48 in-in in 8.066 Saltbr-in 2.906 HRD-in -90.51, -54.07 69.36, 14.57 in-in-none SNCiin in-none ActLoopNT-in 2.798 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_iini APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -134.67 APE8-dihe-in -110.11, 125.22 APE8-rot-in 302.19 APE67-dihe-in -61.62, -37.34 -60.6, -34.55 APE12-dist-in 10.447 APE11-dist-in 12.341 APE10-dist-none 999.0 APE9-dist-in 3.806 None None SCS110 XRAY 1.75 0.167 0.204 A 310 295 1 0 0 1 [[44, 313]] 1.0 2cmw CK1_CSNK1G1_HUMAN CK1 3.2e-116 393.3 2 261 260 186 187 188 190 192 73 87 91 161 163 162 164 233 221 216 215 214 213 212 211 210 119 Casein kinase I isoform gamma-1
CK1 CSNK1G2 KC1G2_HUMAN 2C47C P78368 46 337 415.0 5ID:61300 Type1 None DFGin 6.356 14.596 BLAminus DFGAsp-rot-in -130.46, 170.19 65.55, 88.27 199.65, -7.68 -102.77, 30.7 296.19, 90.63 -63.02, -30.33 in-none in 7.865 Saltbr-none 999.0 HRD-in -98.28, -49.29 66.18, 13.24 none-in-in SNCnii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.54, 145.79 APE9-dihe-na 130.26, 167.92 APE8-dihe-in -84.31, 112.7 APE8-rot-in 299.01 APE67-dihe-in -60.37, -38.22 -52.73, -35.19 APE12-dist-in 13.224 APE11-dist-in 12.469 APE10-dist-in 7.664 APE9-dist-in 5.033 None None CSD111 XRAY 2.4 0.211 0.257 C 313 283 9 0 0 0 [[46, 314]] 1.0 2c47 CK1_CSNK1G2_HUMAN CK1 1.5e-117 397.6 1 261 261 187 188 189 191 193 75 89 93 162 164 163 165 234 222 217 216 215 214 213 212 211 120 Casein kinase I isoform gamma-2
CK1 TTBK1 TTBK1_HUMAN 4NFMA Q5TCY1 22 314 1321.0 No_ligand No_ligand None DFGin 5.273 12.877 BLAminus DFGAsp-rot-in -120.48, 172.2 50.57, 99.12 203.37, -22.97 -99.16, 15.76 304.55, 118.22 -58.69, -37.53 in-none in 7.29 Saltbr-none 999.0 HRD-in -72.88, -53.79 71.04, -1.8 none-in-in SNCnii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.78, 8.91 APE9-dihe-na -84.35, -161.43 APE8-dihe-in -79.51, 135.82 APE8-rot-in 299.35 APE67-dihe-in -48.61, -43.6 -70.15, -45.53 APE12-dist-in 11.801 APE11-dist-in 10.662 APE10-dist-in 7.491 APE9-dist-in 4.743 None None None XRAY 2.12 0.206 0.241 A 332 293 0 0 0 0 [[34, 295]] 1.0 4nfm CK1_TTBK1_HUMAN CK1 5.5e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CK1 TTBK1 TTBK1_HUMAN 7JXYB Q5TCY1 20 312 1321.0 VSY:401 Type1.5_Back None DFGin 5.037 12.821 BLAminus DFGAsp-rot-in -128.48, 167.02 61.02, 73.97 205.29, -16.17 -81.31, 25.0 308.05, 139.51 -71.44, -25.56 in-in in 7.518 Saltbr-in 2.808 HRD-in -80.36, -54.74 76.29, -0.77 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_iini APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.25 APE8-dihe-in -84.51, 130.82 APE8-rot-in 316.52 APE67-dihe-in -60.95, -38.13 -60.87, -44.59 APE12-dist-in 11.627 APE11-dist-in 11.179 APE10-dist-none 999.0 APE9-dist-in 4.228 None None None XRAY 2.15 0.202 0.241 B 332 288 5 0 0 5 [[34, 295]] 1.0 7jxy CK1_TTBK1_HUMAN CK1 5.5e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CMGC CDK2 CDK2_HUMAN 3EIDC P24941 1 296 298.0 No_ligand No_ligand None DFGin 6.489 15.863 BLAminus DFGAsp-rot-in -134.04, 176.12 56.38, 81.46 180.44, 9.14 -98.21, 27.52 280.67, 71.27 -62.82, -36.83 in-in in 8.955 Saltbr-in 2.698 HRD-in -81.37, -49.78 74.95, -21.85 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.0 APE8-dihe-in -62.75, 132.6 APE8-rot-in 299.6 APE67-dihe-in -57.24, -38.19 -61.24, -41.52 APE12-dist-in 13.922 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.564 None None None XRAY 3.15 0.207 0.261 C 298 290 6 0 0 2 [[4, 286]] 1.0 3eid CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3EIDA P24941 1 297 298.0 PO5:299 Type1 None DFGin 6.59 15.583 BLAminus DFGAsp-rot-in -132.85, -177.52 48.93, 84.46 181.58, 16.22 -100.76, 28.79 277.88, 66.9 -65.0, -34.5 in-in in 8.664 Saltbr-in 2.841 HRD-in -79.0, -48.15 75.16, -17.88 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -96.83 APE9-dihe-na -46.53, 147.39 APE8-dihe-in -64.52, 140.51 APE8-rot-in 326.76 APE67-dihe-in -65.78, -38.63 -57.31, -43.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.918 APE9-dist-in 4.475 None None None XRAY 3.15 0.207 0.261 A 298 292 5 0 0 2 [[4, 286]] 1.0 3eid CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9GOPA P24941 1 298 298.0 A1IOI:60301 Type1 None DFGin 7.359 15.214 BLAminus DFGAsp-rot-in -127.3, 173.02 54.03, 84.28 209.79, -4.1 -99.69, 32.25 282.59, 81.45 -70.11, -42.44 in-in in 8.723 Saltbr-in 2.939 HRD-in -74.49, -42.35 70.77, -14.6 in-in-none SNCiin in-none ActLoopNT-in 2.913 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.86 APE8-dihe-in -65.97, 133.38 APE8-rot-in 277.05 APE67-dihe-in -57.91, -32.79 -19.7, -52.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.633 None None None XRAY 2.158 0.232 0.271 A 298 291 7 0 0 7 [[4, 286]] 1.0 9gop CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDKL1 CDKL1_HUMAN 4AGUA Q00532 2 291 357.0 D15:500 Type1 None DFGin 6.926 15.225 BLAminus DFGAsp-rot-in -125.36, -173.19 61.0, 84.36 187.74, 30.96 -106.79, 0.32 274.19, 82.71 -54.94, -33.89 in-in in 8.329 Saltbr-in 2.668 HRD-in -62.63, -48.4 73.42, -8.74 in-in-none SNCiin in-none ActLoopNT-in 2.806 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.22 APE8-rot-in 301.17 APE67-dihe-in -58.09, -27.23 -56.92, -32.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T159D,Y161E None None XRAY 2.4 0.189 0.226 A 311 277 13 0 0 12 [[4, 287]] 1.0 4agu CMGC_CDKL1_HUMAN CMGC 3e-80 275.7 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 1
CMGC CDKL1 CDKL1_HUMAN 4AGUB Q00532 3 292 357.0 D15:500 Type1 None DFGin 6.911 15.242 BLAminus DFGAsp-rot-in -123.13, -174.59 61.67, 77.11 206.36, 39.27 -99.83, 8.36 278.04, 80.77 -62.15, -31.07 in-in in 8.312 Saltbr-in 2.668 HRD-in -65.94, -47.41 70.79, -7.65 in-in-none SNCiin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.96 APE8-rot-in 300.0 APE67-dihe-in -56.83, -27.96 -64.83, -28.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T159D,Y161E None None XRAY 2.4 0.189 0.226 B 311 276 14 0 0 12 [[4, 287]] 1.0 4agu CMGC_CDKL1_HUMAN CMGC 3e-80 275.7 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 1
CMGC CDKL1 CDKL1_HUMAN 4AGUC Q00532 2 291 357.0 D15:500 Type1 None DFGin 7.076 15.076 BLAminus DFGAsp-rot-in -126.2, -170.17 57.04, 81.0 185.68, 32.36 -105.59, 6.66 281.53, 85.88 -54.99, -37.13 in-in in 8.283 Saltbr-in 2.658 HRD-in -56.25, -49.02 74.36, -3.78 in-in-none SNCiin in-none ActLoopNT-in 2.791 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.06 APE8-rot-in 293.41 APE67-dihe-in -52.47, -36.63 -43.96, -43.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T159D,Y161E None None XRAY 2.4 0.189 0.226 C 311 278 12 0 0 12 [[4, 287]] 1.0 4agu CMGC_CDKL1_HUMAN CMGC 3e-80 275.7 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 1
CMGC CLK1 CLK1_HUMAN 6Q8PA P49759 148 482 484.0 HQB:60501 Type1 None DFGin 7.111 14.533 BLAminus DFGAsp-rot-in -124.47, -177.12 56.99, 94.11 192.42, 29.18 -115.67, 29.05 294.23, 87.9 -80.98, -10.13 in-in in 9.013 Saltbr-in 3.418 HRD-in -77.51, -42.79 69.43, -19.47 in-in-none SNCiin in-none ActLoopNT-in 3.131 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -135.51, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.79 APE8-rot-in 323.11 APE67-dihe-in -68.72, -18.82 -64.59, -40.03 APE12-dist-in 13.204 APE11-dist-in 11.201 APE10-dist-in 7.288 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 A 339 334 1 0 0 1 [[161, 477]] 1.0 6q8p CMGC_CLK1_HUMAN CMGC 2.6e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6Q8PC P49759 148 483 484.0 HQB:60501 Type1 None DFGin 7.261 13.945 BLAminus DFGAsp-rot-in -128.5, 178.53 59.41, 97.23 198.8, -47.44 -121.71, 37.79 304.27, 105.41 -86.72, -22.18 in-in in 8.676 Saltbr-in 3.006 HRD-in -68.24, -39.01 69.57, -23.21 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -136.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.77 APE8-rot-in 314.52 APE67-dihe-in -61.24, -29.44 -57.39, -46.95 APE12-dist-in 13.763 APE11-dist-in 11.126 APE10-dist-in 7.295 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 C 339 333 3 0 0 1 [[161, 477]] 1.0 6q8p CMGC_CLK1_HUMAN CMGC 2.6e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC DYRK1A DYR1A_HUMAN 6S11B Q13627 136 480 763.0 KQE:501 Type1 None DFGin 7.321 14.74 BLAminus DFGAsp-rot-in -122.66, 164.68 70.6, 90.6 194.98, -15.02 -105.94, 27.83 286.74, 77.35 -71.95, -23.72 in-in in 8.564 Saltbr-in 3.103 HRD-in -69.08, -43.23 70.93, 5.16 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -126.36, 176.02 APE9-dihe-na 69.06, 141.8 APE8-dihe-in -64.1, 141.34 APE8-rot-in 291.06 APE67-dihe-in -52.52, -31.33 -58.27, -46.65 APE12-dist-none 999.0 APE11-dist-in 11.465 APE10-dist-in 7.262 APE9-dist-in 3.159 None PTR321 PTR321 XRAY 2.445 0.173 0.21 B 361 330 15 0 0 3 [[159, 479]] 1.0 6s11 CMGC_DYRK1A_HUMAN CMGC 8.7e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7Z5NH Q13627 135 480 763.0 3NG:501 Type1 None DFGin 6.679 14.847 BLAminus DFGAsp-rot-in -128.66, -179.58 53.82, 77.25 203.79, -10.14 -93.05, 20.83 280.85, 75.88 -63.97, -13.6 in-in in 9.075 Saltbr-in 3.001 HRD-in -63.15, -47.83 74.92, 6.9 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none nonTYR APEdihe_aaini APEdist_niii APE10-dihe-na -156.21, 166.85 APE9-dihe-na 64.29, 161.67 APE8-dihe-in -89.72, 140.84 APE8-rot-none 999.0 APE67-dihe-in -54.39, -32.97 -48.02, -56.25 APE12-dist-none 999.0 APE11-dist-in 10.614 APE10-dist-in 7.767 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.77 0.207 0.252 H 370 307 39 0 0 4 [[159, 479]] 1.0 7z5n CMGC_DYRK1A_HUMAN CMGC 9.5e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 4DITA P49841 35 387 420.0 0KD:501 Type1 None DFGin 6.805 13.948 BLAminus DFGAsp-rot-in -145.37, 179.76 65.92, 81.37 185.26, 44.88 -105.97, 22.54 288.96, 82.14 -68.29, -17.95 in-in in 8.825 Saltbr-in 2.717 HRD-in -69.87, -50.6 73.87, 5.2 in-in-none SNCiin in-none ActLoopNT-in 2.939 ActLoopCT-none nonTYR APEdihe_aannn APEdist_iinn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 14.5 999.0, 999.0 APE12-dist-in 13.489 APE11-dist-in 10.385 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR216 PTR216 XRAY 2.6 0.243 0.304 A 382 329 24 0 0 4 [[56, 340]] 1.0 4dit CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.3 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4FV4A P28482 9 357 360.0 EK7:60401 Type1 None DFGin 6.926 15.489 BLAminus DFGAsp-rot-in -127.76, 178.3 63.88, 86.85 205.38, -23.99 -108.47, 28.84 281.36, 73.37 -69.43, -40.09 in-in in 9.642 Saltbr-in 2.648 HRD-in -75.2, -46.77 73.02, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.837 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -41.0 APE9-dihe-na -73.39, 169.26 APE8-dihe-in -71.16, 102.82 APE8-rot-in 309.16 APE67-dihe-in -58.85, -32.49 -29.11, -51.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.377 APE9-dist-in 4.371 None None CME161 XRAY 2.5 0.219 0.253 A 360 330 19 0 0 12 [[25, 313]] 1.0 4fv4 CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV5A P28482 9 357 360.0 EK9:60401 Type1 None DFGin 6.911 15.436 BLAminus DFGAsp-rot-in -125.94, 174.49 65.85, 87.03 191.9, -3.89 -106.87, 28.63 280.66, 75.44 -65.59, -45.85 in-in in 9.354 Saltbr-in 2.71 HRD-in -72.18, -50.7 73.7, -7.14 in-in-none SNCiin in-none ActLoopNT-in 2.767 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.89 APE8-dihe-in -70.68, 121.16 APE8-rot-in 311.58 APE67-dihe-in -59.32, -29.75 -54.36, -44.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.642 None None CME161 XRAY 2.4 0.206 0.248 A 360 331 18 0 0 14 [[25, 313]] 1.0 4fv5 CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV6A P28482 9 357 360.0 E57:60401 Type1 None DFGin 6.952 14.813 BLAminus DFGAsp-rot-in -126.85, -179.36 58.14, 87.74 187.91, 14.77 -105.16, 32.96 280.54, 72.76 -66.83, -48.49 in-in in 9.119 Saltbr-in 2.728 HRD-in -73.71, -49.52 71.01, 1.58 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 164.79 APE8-dihe-in -71.11, 129.52 APE8-rot-in 305.06 APE67-dihe-in -62.14, -26.42 -57.08, -45.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.348 None None None XRAY 2.5 0.222 0.249 A 360 332 17 0 0 14 [[25, 313]] 1.0 4fv6 CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV8A P28482 8 357 360.0 E63:60401 Type1 None DFGin 7.006 15.497 BLAminus DFGAsp-rot-in -127.0, -178.27 61.48, 83.09 215.8, -43.43 -106.04, 21.77 282.14, 67.68 -61.35, -37.24 in-in in 9.531 Saltbr-in 2.852 HRD-in -71.05, -46.98 70.21, -0.53 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -57.07 APE9-dihe-na -109.25, -165.95 APE8-dihe-in -76.52, 120.67 APE8-rot-in 315.06 APE67-dihe-in -62.49, -24.63 -55.08, -35.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.536 APE9-dist-in 4.721 None None CME161 XRAY 2.0 0.188 0.227 A 360 334 16 0 0 13 [[25, 313]] 1.0 4fv8 CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV9A P28482 8 357 360.0 E71:60401 Type1 None DFGin 6.928 15.636 BLAminus DFGAsp-rot-in -132.32, -178.13 60.98, 82.89 199.61, -17.9 -105.46, 23.11 283.0, 73.52 -62.53, -38.05 in-in in 9.598 Saltbr-in 3.038 HRD-in -72.61, -49.16 72.56, -1.28 in-in-none SNCiin in-none ActLoopNT-in 2.743 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 179.68 APE8-dihe-in -79.93, 120.69 APE8-rot-in 307.61 APE67-dihe-in -59.23, -20.77 -43.94, -53.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.569 None None CME161 XRAY 2.11 0.201 0.238 A 360 332 18 0 0 14 [[25, 313]] 1.0 4fv9 CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BUEA P28482 11 358 360.0 4V8:60401 Type1 None DFGin 6.9 15.224 BLAminus DFGAsp-rot-in -122.39, -177.08 63.38, 82.69 187.93, 6.91 -105.24, 21.84 282.5, 70.9 -61.62, -35.58 in-in in 9.256 Saltbr-in 2.813 HRD-in -71.44, -49.4 73.74, -0.74 in-in-none SNCiin in-none ActLoopNT-in 2.793 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.04 APE8-rot-in 329.09 APE67-dihe-in -60.95, -23.57 -107.06, -4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.185 0.23 A 361 329 19 0 0 15 [[25, 313]] 1.0 5bue CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BUIA P28482 11 358 360.0 4V9:60402 Type1 None DFGin 6.991 15.3 BLAminus DFGAsp-rot-in -130.19, 179.53 65.05, 80.02 197.0, -9.11 -99.3, 20.21 283.96, 66.32 -59.55, -33.7 in-in in 9.549 Saltbr-in 2.722 HRD-in -68.56, -51.77 75.84, -7.59 in-in-none SNCiin in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -130.01 APE8-rot-in 334.62 APE67-dihe-in -56.78, -27.08 -106.13, -3.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.12 0.172 0.222 A 361 338 10 0 0 10 [[25, 313]] 1.0 5bui CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BUJA P28482 9 358 360.0 4VB:60401 Type1 None DFGin 6.999 15.405 BLAminus DFGAsp-rot-in -125.43, -179.58 67.11, 82.68 208.93, -35.9 -104.4, 22.22 283.46, 67.98 -61.34, -32.84 in-in in 9.526 Saltbr-in 2.694 HRD-in -77.84, -46.67 74.74, -8.15 in-in-none SNCiin in-none ActLoopNT-in 2.787 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.23 APE8-rot-in 314.32 APE67-dihe-in -58.67, -24.13 -104.72, -0.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.173 0.206 A 361 331 19 0 0 15 [[25, 313]] 1.0 5buj CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BVDA P28482 9 358 360.0 4VF:60401 Type1 None DFGin 7.012 14.82 BLAminus DFGAsp-rot-in -120.88, -174.96 58.49, 83.25 189.57, 7.38 -99.87, 23.43 283.53, 71.8 -56.85, -34.73 in-in in 9.264 Saltbr-in 2.627 HRD-in -80.64, -49.81 78.16, -6.37 in-in-none SNCiin in-none ActLoopNT-in 2.72 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.19 APE8-rot-in 306.38 APE67-dihe-in -62.44, -24.22 -51.26, -49.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.172 0.207 A 361 330 20 0 0 16 [[25, 313]] 1.0 5bvd CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BVEA P28482 9 358 360.0 4VG:60401 Type1 None DFGin 6.995 14.775 BLAminus DFGAsp-rot-in -125.12, -174.29 54.55, 82.42 191.52, 7.85 -96.55, 21.3 282.29, 70.85 -61.67, -24.38 in-in in 9.139 Saltbr-in 2.729 HRD-in -80.4, -49.72 75.16, -2.3 in-in-none SNCiin in-none ActLoopNT-in 2.781 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.36 APE8-rot-in 307.25 APE67-dihe-in -61.28, -26.45 -50.74, -47.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.175 0.22 A 361 330 20 0 0 16 [[25, 313]] 1.0 5bve CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BVFA P28482 9 358 360.0 4VJ:60401 Type1 None DFGin 6.801 14.714 BLAminus DFGAsp-rot-in -123.98, -172.37 55.64, 78.56 188.66, 15.06 -97.05, 25.41 283.39, 68.26 -60.16, -26.7 in-in in 9.262 Saltbr-in 2.69 HRD-in -79.7, -47.41 71.71, 1.48 in-in-none SNCiin in-none ActLoopNT-in 2.691 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.62, -24.81 999.0, -48.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.183 0.221 A 361 327 23 0 0 17 [[25, 313]] 1.0 5bvf CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3I5ZA P28482 8 357 360.0 Z48:60401 Type1 None DFGin 6.917 15.249 BLAminus DFGAsp-rot-in -127.32, 174.22 70.2, 66.73 192.31, -4.91 -83.95, 23.54 288.3, 68.12 -65.3, -33.09 in-in in 9.313 Saltbr-in 2.715 HRD-in -75.44, -48.03 71.03, -6.74 in-in-none SNCiin in-none ActLoopNT-in 2.717 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -13.55 APE9-dihe-na -121.16, 175.77 APE8-dihe-in -61.26, 116.09 APE8-rot-in 314.5 APE67-dihe-in -57.72, -29.32 -61.25, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.812 APE9-dist-in 4.954 None None None XRAY 2.2 0.217 0.258 A 380 331 19 0 0 14 [[25, 313]] 1.0 3i5z CMGC_MAPK1_HUMAN CMGC 1.1e-85 293.5 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3I60A P28482 8 358 360.0 E86:60401 Type1 None DFGin 6.968 15.153 BLAminus DFGAsp-rot-in -121.98, 176.49 63.3, 79.85 194.72, -9.39 -98.81, 21.48 280.47, 70.03 -59.78, -40.19 in-in in 9.289 Saltbr-in 3.111 HRD-in -73.88, -46.85 79.23, -3.42 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.19 APE8-dihe-in -93.47, 121.54 APE8-rot-in 308.65 APE67-dihe-in -68.68, -19.01 -43.75, -44.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.496 None None None XRAY 2.5 0.211 0.248 A 380 335 16 0 0 13 [[25, 313]] 1.0 3i60 CMGC_MAPK1_HUMAN CMGC 1.1e-85 293.5 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPIA P28482 10 356 360.0 N0V:60401 Type1.5_Front None DFGin 6.816 16.494 BLAminus DFGAsp-rot-in -135.48, 169.13 71.03, 93.69 199.93, -40.15 -111.04, 34.22 293.24, 78.08 -67.49, -29.15 in-in in 9.892 Saltbr-in 3.054 HRD-in -72.72, -50.31 76.41, -2.79 in-in-none SNCiin in-none ActLoopNT-in 2.808 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.69 APE8-rot-in 306.85 APE67-dihe-in -62.81, -15.96 -67.99, -45.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO185,PTR187 TPO185,PTR187 XRAY 3.0 0.189 0.26 A 354 326 17 0 0 12 [[25, 313]] 1.0 6opi CMGC_MAPK1_HUMAN CMGC 8.9e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.87 13.865 BLAminus DFGAsp-rot-in -125.0, 176.56 71.88, 86.33 191.14, -10.66 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.793 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361 312 42 0 0 20 [[58, 569]] 1.0 4f99 OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.759 13.936 BLAminus DFGAsp-rot-in -128.61, 175.54 70.41, 87.99 191.32, -8.92 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.757 Saltbr-in 3.408 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361 315 41 0 0 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.913 14.207 BLAminus DFGAsp-rot-in -118.89, -178.58 68.69, 81.33 193.06, -3.59 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.846 Saltbr-in 2.634 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.643 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361 317 41 0 0 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.888 14.044 BLAminus DFGAsp-rot-in -126.02, 169.07 75.11, 84.03 194.62, -1.51 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.937 Saltbr-in 2.775 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.714 None None None XRAY 1.67 0.158 0.185 A 358 345 5 0 0 5 [[58, 569]] 1.0 6ya7 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus DFGAsp-rot-in -118.93, 173.08 76.34, 83.66 188.96, -2.47 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BA O00311 39 572 574.0 0SY:601 Type1 None DFGin 5.763 14.014 BLAminus DFGAsp-rot-in -127.87, 167.58 73.15, 98.39 210.16, -36.47 -107.19, 18.49 295.91, 97.29 -66.44, -7.97 in-in in 9.088 Saltbr-in 2.963 HRD-in -56.22, -51.45 80.31, -5.48 in-in-none SNCiin in-none ActLoopNT-in 2.827 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -71.45, 117.57 APE8-rot-in 316.95 APE67-dihe-in -71.7, -9.89 -46.76, -40.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 A 361 318 38 0 0 17 [[58, 569]] 1.0 4f9b OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BC O00311 37 572 574.0 0SY:601 Type1 None DFGin 5.596 14.137 BLAminus DFGAsp-rot-in -121.21, 173.13 67.81, 82.77 213.16, -38.5 -85.78, 14.03 293.34, 97.94 -53.73, -27.05 in-in in 8.886 Saltbr-in 2.749 HRD-in -63.82, -49.28 75.73, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.786 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.89, 119.22 APE8-rot-in 309.91 APE67-dihe-in -59.77, -15.79 -42.06, -45.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 C 361 316 42 0 0 21 [[58, 569]] 1.0 4f9b OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9CA O00311 41 572 574.0 0SX:601 Type1 None DFGin 5.868 14.2 BLAminus DFGAsp-rot-in -130.13, 163.69 79.42, 87.08 198.91, -9.59 -94.29, 18.63 289.91, 100.22 -72.97, -7.76 in-in in 8.945 Saltbr-in 2.697 HRD-in -63.65, -50.25 73.79, -1.33 in-in-none SNCiin in-none ActLoopNT-in 2.78 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -72.81, 123.96 APE8-rot-in 305.35 APE67-dihe-in -59.52, -17.81 -47.91, -44.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.08 0.206 0.249 A 361 306 48 0 0 26 [[58, 569]] 1.0 4f9c OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA6A O00311 38 573 574.0 0SX:60601,BO3:60604 Type1,Type1 None DFGin 5.683 14.123 BLAminus DFGAsp-rot-in -124.62, 164.87 81.15, 86.75 201.51, -13.15 -92.84, 17.97 293.82, 101.75 -74.2, -7.34 in-in in 8.984 Saltbr-in 2.653 HRD-in -67.91, -46.07 79.98, -17.89 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 166.27, -149.55 APE8-dihe-in -136.79, 136.61 APE8-rot-in 295.13 APE67-dihe-inflip 96.71, -11.03 -52.89, 131.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.586 None None None XRAY 1.44 0.168 0.193 A 359 340 12 0 0 12 [[58, 569]] 1.0 6ya6 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.54 13.598 BLAminus DFGAsp-rot-in -149.66, -173.45 57.49, 66.53 201.33, -9.38 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.363 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.401 APE11-dist-in 11.328 APE10-dist-in 5.406 APE9-dist-in 3.601 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405 385 17 0 0 1 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.362 13.613 BLAminus DFGAsp-rot-in -140.88, -173.22 59.3, 72.64 207.2, -16.91 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.608 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.836 APE11-dist-in 11.233 APE10-dist-in 5.394 APE9-dist-in 3.693 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405 384 18 0 0 2 [[571, 832]] 1.0 4yzc OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3KA O75460 562 963 977.0 SJS:1001 Type1 None DFGin 5.733 14.486 BLAminus DFGAsp-rot-in -136.61, -178.37 67.07, 78.89 204.21, -11.93 -100.93, 17.07 281.07, 41.19 -67.11, -27.01 in-in in 8.204 Saltbr-in 2.756 HRD-in -74.42, -52.27 75.94, 0.0 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 69.85 APE9-dihe-na 125.22, -177.52 APE8-dihe-in -111.61, 120.85 APE8-rot-in 306.38 APE67-dihe-inflip 105.25, -16.79 -50.22, 133.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.729 APE9-dist-in 3.977 None None None XRAY 2.08 0.192 0.217 A 434 398 4 0 0 4 [[571, 832]] 1.0 6w3k OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER GAK GAK_HUMAN 4Y8DA O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.562 13.518 BLAminus DFGAsp-rot-in -138.4, -164.21 74.62, 66.04 199.54, -60.61 -93.04, 16.88 304.79, 110.01 -68.29, -18.06 in-in in 8.973 Saltbr-in 2.822 HRD-in -78.84, -52.81 74.15, 0.63 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 A 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4Y8DB O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.558 13.438 BLAminus DFGAsp-rot-in -140.66, -164.98 74.22, 67.3 200.82, -62.27 -94.1, 19.71 305.39, 110.44 -72.07, -18.1 in-in in 8.927 Saltbr-in 2.81 HRD-in -76.85, -53.12 74.48, -1.34 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 B 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER ULK2 ULK2_HUMAN 6QAUB Q8IYT8 1 274 1036.0 1FV:60301 Type1 None DFGin 6.69 14.941 BLAminus DFGAsp-rot-in -136.25, 168.35 65.98, 84.31 191.46, -2.27 -99.13, 17.87 284.11, 83.42 -56.69, -27.27 in-in in 9.16 Saltbr-in 2.803 HRD-in -82.01, -52.27 83.93, -11.12 in-in-none SNCiin in-none ActLoopNT-in 3.005 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -75.13, -14.46 999.0, 14.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.48 0.198 0.237 B 280 264 10 0 0 10 [[7, 271]] 1.0 6qau OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.965 14.31 BLAminus DFGAsp-rot-in -123.5, -167.41 55.36, 79.67 189.86, 15.66 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 na-na na 15.412 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.014 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279 260 14 0 0 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
STE MAP2K7 MP2K7_HUMAN 5Z1DA O14733 103 403 419.0 95U:60501 Type1 None DFGin 5.857 14.585 BLAminus DFGAsp-rot-in -132.64, 165.55 65.51, 87.28 188.49, -3.46 -111.34, 26.51 319.06, 84.39 -58.48, -30.36 na-na na 8.357 Saltbr-na 4.043 HRD-in -83.1, -42.1 68.08, 4.78 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.65 APE8-dihe-in -8.48, 107.0 APE8-rot-na 193.18 APE67-dihe-in -53.9, -37.87 -45.41, -42.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.998 None None None XRAY 2.28 0.195 0.258 A 324 274 27 0 0 13 [[120, 380]] 1.0 5z1d STE_MAP2K7_HUMAN STE 1e-79 273.6 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.195 14.549 BLAminus DFGAsp-rot-in -146.55, 178.23 54.3, 83.97 192.46, -3.23 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 na-na na 8.345 Saltbr-na 3.36 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307 265 33 0 0 19 [[120, 380]] 1.0 6yg3 STE_MAP2K7_HUMAN STE 2.5e-80 275.5 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP3K14 M3K14_HUMAN 4G3DD Q99558 338 657 947.0 No_ligand No_ligand None DFGin 5.247 13.197 BLAminus DFGAsp-rot-in -139.97, -172.27 56.52, 77.31 194.92, -10.61 -95.91, 22.53 297.92, 87.23 -51.62, -29.6 in-in in 8.447 Saltbr-in 3.513 HRD-in -79.01, -53.56 97.41, -27.23 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 88.51 APE9-dihe-na -78.1, -164.4 APE8-dihe-in -58.77, 132.43 APE8-rot-in 301.85 APE67-dihe-in -63.25, -43.05 -56.52, -49.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.409 APE9-dist-in 3.602 None None None XRAY 2.9 0.206 0.266 D 371 290 17 0 0 13 [[399, 652]] 1.0 4g3d STE_MAP3K14_HUMAN STE 1.4e-62 217.5 4 252 249 533 534 535 537 539 429 440 444 512 514 513 515 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4G3DE Q99558 332 663 947.0 No_ligand No_ligand None DFGin 5.283 12.998 BLAminus DFGAsp-rot-in -137.41, -171.56 53.74, 79.67 199.21, -15.84 -98.49, 16.37 295.95, 82.21 -51.27, -29.34 in-in in 8.088 Saltbr-in 3.275 HRD-in -56.22, -43.54 79.99, -16.43 in-in-none SNCiin in-none ActLoopNT-in 3.058 ActLoopCT-none nonTYR APEdihe_aanin APEdist_nnii APE10-dihe-na 999.0, 175.31 APE9-dihe-na -160.21, -138.78 APE8-dihe-none -77.0, 999.0 APE8-rot-in 301.74 APE67-dihe-none 999.0, -37.88 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.602 APE9-dist-in 4.079 None None None XRAY 2.9 0.206 0.266 E 371 283 36 0 0 15 [[399, 652]] 1.0 4g3d STE_MAP3K14_HUMAN STE 1.4e-62 217.5 4 252 249 533 534 535 537 539 429 440 444 512 514 513 515 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
STE MAP3K5 M3K5_HUMAN 6OYTA Q99683 667 939 1374.0 NJV:61001 Type1 None DFGin 5.681 13.351 BLAminus DFGAsp-rot-in -125.18, 173.88 59.78, 86.22 201.94, -12.35 -94.31, 25.78 300.06, 101.7 -62.97, -32.35 in-in in 8.832 Saltbr-in 2.26 HRD-in -73.98, -49.46 76.75, 0.8 in-in-none SNCiin in-none ActLoopNT-in 2.979 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 A 280 221 52 0 0 20 [[678, 938]] 1.0 6oyt STE_MAP3K5_HUMAN STE 5.2e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTC Q99683 671 938 1374.0 NJV:61001 Type1 None DFGin 6.079 13.489 BLAminus DFGAsp-rot-in -119.54, 172.14 56.5, 86.88 205.51, -12.35 -93.47, 25.36 302.99, 99.79 -64.69, -32.12 in-in in 8.321 Saltbr-in 2.529 HRD-in -71.89, -48.46 74.08, 0.71 in-in-none SNCiin in-none ActLoopNT-in 3.275 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.69, -21.53 999.0, -119.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 C 280 236 32 0 0 13 [[678, 938]] 1.0 6oyt STE_MAP3K5_HUMAN STE 5.2e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTD Q99683 667 939 1374.0 NJV:61002 Type1 None DFGin 5.873 13.601 BLAminus DFGAsp-rot-in -124.35, 174.62 60.77, 86.25 201.7, -14.23 -96.47, 25.37 301.41, 82.49 -61.64, -30.64 in-in in 9.067 Saltbr-in 2.509 HRD-in -72.35, -49.7 75.51, 0.65 in-in-none SNCiin in-none ActLoopNT-in 2.818 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -134.49 APE8-dihe-in -107.42, 132.24 APE8-rot-in 319.21 APE67-dihe-in -73.68, -28.35 -46.85, -37.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.788 None None None XRAY 2.824 0.235 0.29 D 280 250 23 0 0 10 [[678, 938]] 1.0 6oyt STE_MAP3K5_HUMAN STE 5.2e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UP3B Q99683 671 939 1374.0 8GS:1000 Type1 None DFGin 6.404 13.522 BLAminus DFGAsp-rot-in -145.21, 155.75 74.64, 95.67 202.94, -9.78 -108.04, 14.34 302.59, 105.08 -64.34, -17.97 in-in in 8.566 Saltbr-in 2.91 HRD-in -87.24, -40.99 75.36, -9.84 in-in-none SNCiin in-none ActLoopNT-in 3.023 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.91 APE8-dihe-in -57.21, 126.4 APE8-rot-in 314.64 APE67-dihe-in -121.68, -3.36 -59.97, -11.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.493 None None None XRAY 2.95 0.244 0.289 B 271 243 26 0 0 11 [[678, 938]] 1.0 5up3 STE_MAP3K5_HUMAN STE 4.6e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2NB Q99683 670 939 1374.0 KK8:1001 Type1 None DFGin 6.543 13.925 BLAminus DFGAsp-rot-in -124.43, -172.06 45.44, 94.03 201.32, -28.65 -100.49, 19.41 297.14, 84.65 -62.68, -39.36 in-in in 8.526 Saltbr-in 2.317 HRD-in -77.48, -52.13 80.81, -2.87 in-in-none SNCiin in-none ActLoopNT-in 3.176 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -34.96 APE9-dihe-na 147.14, -170.88 APE8-dihe-in -105.95, 128.57 APE8-rot-in 300.89 APE67-dihe-in -77.71, -0.68 -49.6, -53.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.857 APE9-dist-in 3.588 None TPO838 TPO838 XRAY 2.098 0.217 0.257 B 295 250 20 0 0 10 [[678, 938]] 1.0 6e2n STE_MAP3K5_HUMAN STE 6.3e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 7MU6B Q99683 671 940 1374.0 A1AWT:1001 Type1 None DFGin 6.472 13.842 BLAminus DFGAsp-rot-in -137.24, 175.06 55.73, 97.84 197.32, -22.26 -102.69, 23.8 295.93, 95.1 -68.36, -28.7 in-in in 8.476 Saltbr-in 2.441 HRD-in -80.7, -46.25 77.78, 2.33 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 66.13 APE9-dihe-na -85.74, -166.57 APE8-dihe-in -87.23, 138.03 APE8-rot-in 306.07 APE67-dihe-in -71.64, -12.66 -62.6, -45.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.317 APE9-dist-in 3.356 None None None XRAY 2.165 0.191 0.214 B 334 261 9 0 0 9 [[678, 938]] 1.0 7mu6 STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 6NFZA Q92918 7 292 833.0 B49:401 Type1 None DFGin 6.284 14.02 BLAminus DFGAsp-rot-in -132.74, -179.97 58.53, 80.12 190.95, 31.78 -96.32, 31.7 293.92, 71.67 -62.29, -28.15 in-none in 8.634 Saltbr-none 999.0 HRD-in -77.39, -48.16 72.34, -9.45 none-in-in SNCnii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.28, 161.74 APE9-dihe-na 145.04, -157.57 APE8-dihe-in -127.09, 102.67 APE8-rot-in 298.6 APE67-dihe-in -54.23, -29.76 -34.34, -51.63 APE12-dist-in 8.241 APE11-dist-in 11.626 APE10-dist-in 6.178 APE9-dist-in 3.916 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 A 309 270 16 0 0 0 [[17, 274]] 1.0 6nfz STE_MAP4K1_HUMAN STE 1.8e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE PAK1 PAK1_HUMAN 4DAWA Q13153 249 542 545.0 0H2:601 Type1 None DFGin 6.003 15.555 BLAminus DFGAsp-rot-in -145.17, -172.18 68.39, 87.65 203.02, -20.16 -98.45, 24.44 292.06, 86.63 -67.73, -11.03 in-none in 9.893 Saltbr-none 999.0 HRD-in -68.43, -51.96 75.51, -0.37 none-in-in SNCnii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -25.02 APE9-dihe-na -71.13, 167.89 APE8-dihe-in -72.39, 123.36 APE8-rot-in 310.01 APE67-dihe-in -62.64, -23.02 -43.95, -50.55 APE12-dist-in 8.844 APE11-dist-in 10.963 APE10-dist-in 4.954 APE9-dist-in 3.225 K299R TPO423 TPO423 XRAY 2.0 0.203 0.238 A 297 294 0 0 0 0 [[270, 521]] 1.0 4daw STE_PAK1_HUMAN STE 7.5e-95 323.1 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 2HY81 Q13153 249 541 545.0 1ST:201 Type1 None DFGin 6.311 15.646 BLAminus DFGAsp-rot-in -141.81, -175.39 62.15, 82.56 195.53, -11.86 -97.27, 31.86 287.16, 72.33 -72.78, -7.5 in-none in 9.972 Saltbr-none 999.0 HRD-in -69.86, -49.3 75.07, -4.86 none-in-in SNCnii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.75, -18.53 APE9-dihe-na -69.92, -171.39 APE8-dihe-in -100.69, 123.46 APE8-rot-in 301.63 APE67-dihe-in -57.72, -21.79 -25.33, -67.16 APE12-dist-in 8.906 APE11-dist-in 11.053 APE10-dist-in 5.133 APE9-dist-in 3.348 K299R,T423E None None XRAY 2.0 0.208 0.234 1 297 293 0 0 0 0 [[270, 521]] 1.0 2hy8 STE_PAK1_HUMAN STE 3.1e-94 321.1 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE STK4 STK4_HUMAN 6YATB Q13043 29 307 487.0 OJ5:401 Type1 None DFGin 6.466 13.854 BLAminus DFGAsp-rot-in -122.05, 162.57 77.71, 80.56 202.03, -18.93 -97.31, 25.12 292.31, 85.07 -58.76, -37.95 in-none in 8.684 Saltbr-none 999.0 HRD-in -73.27, -56.52 82.91, -0.91 none-in-in SNCnii in-in ActLoopNT-in 2.751 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.95, 157.18 APE9-dihe-na 132.69, -166.17 APE8-dihe-in -108.9, 116.74 APE8-rot-in 312.41 APE67-dihe-in -55.33, -29.29 -39.0, -55.77 APE12-dist-in 8.432 APE11-dist-in 11.492 APE10-dist-in 5.789 APE9-dist-in 3.286 None TPO177,TPO183 TPO177,TPO183 XRAY 2.58 0.227 0.259 B 314 276 3 0 0 0 [[30, 281]] 1.0 6yat STE_STK4_HUMAN STE 4.4e-102 346.9 2 257 256 166 167 168 170 172 59 73 77 146 148 147 149 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STE TNIK TNIK_HUMAN 6RA5B Q9UKE5 14 310 1360.0 No_ligand No_ligand None DFGin 5.788 14.265 BLAminus DFGAsp-rot-in -136.76, 172.1 63.28, 95.48 196.41, 51.45 -100.13, 6.47 275.29, 87.87 -57.63, -20.13 in-none in 8.566 Saltbr-none 999.0 HRD-in -68.06, -48.15 74.67, 0.64 none-in-in SNCnii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.41, 141.46 APE9-dihe-na 147.76, -160.31 APE8-dihe-in -111.74, 117.5 APE8-rot-in 316.28 APE67-dihe-in -47.73, -42.39 -30.97, -64.12 APE12-dist-in 8.838 APE11-dist-in 11.283 APE10-dist-in 5.559 APE9-dist-in 3.461 None TPO181,TPO187 TPO181,TPO187 XRAY 2.9 999.0 999.0 B 306 283 14 0 0 7 [[25, 289]] 1.0 6ra5 STE_TNIK_HUMAN STE 3.1e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 2X7FD Q9UKE5 17 306 1360.0 824:500 Type1 None DFGin 6.647 15.046 BLAminus DFGAsp-rot-in -124.52, 178.85 56.71, 102.04 191.82, 48.12 -114.11, 22.87 287.2, 83.98 -65.42, -48.91 in-none in 9.444 Saltbr-none 999.0 HRD-in -66.67, -40.26 66.21, -2.06 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 119.49 APE8-rot-none 999.0 APE67-dihe-in -52.92, -32.7 -93.58, 2.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 D 326 236 51 0 0 15 [[25, 289]] 1.0 2x7f STE_TNIK_HUMAN STE 3.8e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 8R7GC Q04771 206 498 509.0 YEE:501 Type1 None DFGin 7.86 12.623 BLAminus DFGAsp-rot-in -132.3, 171.44 65.89, 83.48 198.87, -13.1 -96.38, 20.1 305.34, 173.35 -63.32, -22.24 in-in in 8.155 Saltbr-in 3.027 HRD-in -79.84, -56.85 80.44, 0.82 in-in-none SNCiin in-none ActLoopNT-in 2.792 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -50.52 APE9-dihe-na -69.1, 173.0 APE8-dihe-in -60.22, 124.79 APE8-rot-in 310.22 APE67-dihe-in -65.34, -27.73 -64.05, -29.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.082 APE9-dist-in 3.578 Q207D None None XRAY 2.09 0.228 0.253 C 301 280 13 0 0 12 [[207, 497]] 1.0 8r7g TKL_ACVR1_HUMAN TKL 2e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BMPR2 BMPR2_HUMAN 6UNPA Q13873 199 509 1038.0 ADP:601,ADP:602 ATPlike,Allosteric None DFGin 7.015 14.066 BLAminus DFGAsp-rot-in -140.5, 177.86 62.51, 75.21 192.46, -3.44 -94.82, 26.77 301.08, 104.11 -62.66, -20.97 in-in in 7.983 Saltbr-in 2.832 HRD-in -73.31, -49.03 80.8, -8.07 in-in-none SNCiin in-none ActLoopNT-in 2.92 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -134.35, -10.44 APE9-dihe-na -70.57, -158.87 APE8-dihe-in -91.29, 127.64 APE8-rot-in 299.54 APE67-dihe-in -49.77, -33.71 -61.84, -45.11 APE12-dist-none 999.0 APE11-dist-in 12.741 APE10-dist-in 7.284 APE9-dist-in 4.093 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 A 363 302 9 0 0 9 [[202, 503]] 1.0 6unp TKL_BMPR2_HUMAN TKL 1.2e-74 257.3 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BRAF BRAF_HUMAN 4MNFA P15056 449 720 766.0 29L:801 Type1 None DFGin 6.831 14.084 BLAminus DFGAsp-rot-in -138.14, -173.65 64.87, 78.28 205.18, -20.03 -102.21, 29.93 290.33, 73.26 -66.38, -51.46 in-in in 8.582 Saltbr-in 2.768 HRD-in -70.14, -50.01 76.68, -10.07 in-in-none SNCiin in-none ActLoopNT-in 2.834 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.76 APE8-rot-in 296.87 APE67-dihe-in -62.48, -28.21 -57.0, -49.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.802 0.215 0.275 A 329 257 15 0 0 15 [[457, 716]] 1.0 4mnf TKL_BRAF_HUMAN TKL 1.5e-81 279.9 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.642 14.512 BLAminus DFGAsp-rot-in -134.38, -175.33 55.45, 88.83 204.91, -7.02 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.176 Saltbr-in 3.297 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.567 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301 280 18 0 0 10 [[183, 456]] 1.0 2oic TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K72B Q9NWZ3 165 458 460.0 6QY:504 Type1 None DFGin 6.918 14.797 BLAminus DFGAsp-rot-in -126.83, 172.54 63.1, 86.46 237.93, -47.45 -103.47, 19.92 308.93, 101.56 -64.92, -35.48 in-in in 8.872 Saltbr-in 3.087 HRD-in -67.63, -51.12 79.83, -9.89 in-in-none SNCiin in-none ActLoopNT-in 2.869 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 146.4 APE9-dihe-na 138.09, -173.14 APE8-dihe-in -106.76, 111.81 APE8-rot-in 311.41 APE67-dihe-in -65.66, -17.88 -41.88, -47.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.406 APE9-dist-in 4.084 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 B 301 267 27 0 0 14 [[183, 456]] 1.0 5k72 TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GB Q9NWZ3 165 458 460.0 6R0:503 Type1 None DFGin 6.983 14.576 BLAminus DFGAsp-rot-in -125.44, 169.29 65.46, 85.11 239.35, -39.15 -103.67, 20.54 309.11, 102.13 -65.88, -35.43 in-in in 8.895 Saltbr-in 3.133 HRD-in -66.71, -50.75 79.24, -11.2 in-in-none SNCiin in-none ActLoopNT-in 2.855 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 145.13 APE9-dihe-na 139.01, -174.96 APE8-dihe-in -106.13, 110.24 APE8-rot-in 312.27 APE67-dihe-in -64.1, -19.47 -39.24, -50.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.428 APE9-dist-in 4.132 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 B 301 275 19 0 0 14 [[183, 456]] 1.0 5k7g TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.973 14.137 BLAminus DFGAsp-rot-in -129.45, 177.84 61.74, 86.54 214.43, -46.52 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.098 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.189 APE11-dist-in 11.686 APE10-dist-in 6.444 APE9-dist-in 4.332 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305 297 0 0 0 0 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGDA Q9NWZ3 165 458 460.0 J87:60501 Type1 None DFGin 6.848 14.184 BLAminus DFGAsp-rot-in -141.24, -173.92 62.73, 75.05 193.7, 8.25 -96.24, 8.11 294.89, 87.75 -42.03, -35.64 in-in in 8.834 Saltbr-in 3.375 HRD-in -75.12, -50.55 72.64, 0.08 in-in-none SNCiin in-none ActLoopNT-in 2.678 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.37, -20.6 999.0, -46.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.184 0.23 A 302 268 26 0 0 16 [[183, 456]] 1.0 6egd TKL_IRAK4_HUMAN TKL 2.7e-83 285.5 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.495 BLAminus DFGAsp-rot-in -133.4, -177.52 44.45, 65.76 191.08, -3.01 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.111 Saltbr-in 2.796 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.839 APE10-dist-in 7.032 APE9-dist-in 3.824 D311N None None XRAY 2.65 0.206 0.251 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u97 TKL_IRAK4_HUMAN TKL 3.1e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.045 14.907 BLAminus DFGAsp-rot-in -101.08, -157.39 29.3, 88.18 197.77, -8.47 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.998 Saltbr-in 3.226 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.983 APE11-dist-in 11.951 APE10-dist-in 7.219 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u9a TKL_IRAK4_HUMAN TKL 3.1e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL RIPK3 RIPK3_HUMAN 7MX3A Q9Y572 12 314 518.0 ZOV:401 Type1.5_Back None DFGin 6.222 13.909 BLAminus DFGAsp-rot-in -152.35, -176.12 58.98, 65.68 186.81, 73.74 -88.59, 21.74 285.92, 83.22 -75.2, -29.2 in-in in 7.967 Saltbr-in 2.917 HRD-in -70.69, -48.21 67.95, 8.04 in-in-none SNCiin in-none ActLoopNT-in 3.202 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.66, -25.03 999.0, -33.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 A 319 292 11 0 0 10 [[21, 285]] 1.0 7mx3 TKL_RIPK3_HUMAN TKL 7.6e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_HUMAN 7MX3C Q9Y572 9 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.324 14.409 BLAminus DFGAsp-rot-in -144.06, -179.33 56.59, 66.53 185.77, 1.86 -89.63, 30.65 289.6, 92.66 -94.37, -38.42 in-in in 7.368 Saltbr-in 3.19 HRD-in -62.63, -60.0 65.83, 13.04 in-in-none SNCiin in-none ActLoopNT-in 3.154 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.63, -27.61 999.0, -44.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 C 319 285 18 0 0 10 [[21, 285]] 1.0 7mx3 TKL_RIPK3_HUMAN TKL 7.6e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_HUMAN 7MX3D Q9Y572 12 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.158 13.934 BLAminus DFGAsp-rot-in -152.67, -168.91 60.99, 69.08 190.06, -0.83 -93.05, 21.87 286.54, 121.22 -73.96, -39.13 in-in in 8.115 Saltbr-in 3.229 HRD-in -81.46, -31.71 66.32, -56.05 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.09 APE8-rot-in 303.22 APE67-dihe-in -61.12, -38.55 -55.88, -51.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 D 319 280 19 0 0 14 [[21, 285]] 1.0 7mx3 TKL_RIPK3_HUMAN TKL 7.6e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TKL TGFBR1 TGFR1_HUMAN 3HMMA P36897 201 498 503.0 855:60857 Type1 None DFGin 6.119 13.049 BLAminus DFGAsp-rot-in -127.07, -168.91 53.99, 65.82 202.78, 18.02 -94.96, 13.15 305.68, 3.69 -60.53, -23.27 in-in in 8.024 Saltbr-in 2.812 HRD-in -74.05, -51.32 76.01, -1.97 in-in-none SNCiin in-none ActLoopNT-in 2.934 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.63 APE8-dihe-in -79.78, 120.6 APE8-rot-in 300.84 APE67-dihe-in -55.11, -37.41 -48.22, -47.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.917 None None None XRAY 1.7 0.223 0.241 A 303 293 5 0 0 5 [[205, 494]] 1.0 3hmm TKL_TGFBR1_HUMAN TKL 3.2e-85 291.8 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3TZMA P36897 200 496 503.0 085:1 Type1 None DFGin 6.065 13.106 BLAminus DFGAsp-rot-in -122.58, -169.81 59.22, 59.29 189.29, 30.76 -91.38, 11.48 304.6, 5.41 -64.05, -23.93 in-in in 7.963 Saltbr-in 2.833 HRD-in -81.31, -50.79 80.1, -5.96 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -87.36, 160.54 APE9-dihe-na 102.22, -177.2 APE8-dihe-in -87.37, 126.2 APE8-rot-in 298.62 APE67-dihe-in -59.36, -31.96 -58.47, -41.28 APE12-dist-none 999.0 APE11-dist-in 12.238 APE10-dist-in 6.184 APE9-dist-in 3.825 None None None XRAY 1.7 0.172 0.205 A 309 295 2 0 0 2 [[205, 494]] 1.0 3tzm TKL_TGFBR1_HUMAN TKL 3.5e-85 291.7 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5QINA P37173 240 541 567.0 J2V:601 Type1 None DFGin 7.432 13.692 BLAminus DFGAsp-rot-in -160.38, -171.51 70.13, 63.56 200.22, 32.43 -97.31, 22.31 300.17, 115.61 -64.51, -28.45 in-in in 7.753 Saltbr-in 2.968 HRD-in -64.72, -51.48 70.07, 3.51 in-in-none SNCiin in-none ActLoopNT-in 2.945 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -105.98, 157.24 APE9-dihe-na 110.69, -170.54 APE8-dihe-in -92.43, 119.77 APE8-rot-in 303.14 APE67-dihe-in -57.21, -32.74 -53.66, -41.1 APE12-dist-none 999.0 APE11-dist-in 12.194 APE10-dist-in 6.1 APE9-dist-in 3.918 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 1.57 0.188 0.203 A 316 295 7 0 0 2 [[244, 540]] 1.0 5qin TKL_TGFBR2_HUMAN TKL 2e-77 266.3 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TKL TNNI3K TNI3K_HUMAN 4YFFA Q59H18 445 726 835.0 4CV:801 Type1 None DFGin 6.896 13.887 BLAminus DFGAsp-rot-in -127.46, 175.49 57.0, 94.25 200.01, -8.09 -101.84, 21.43 285.11, 76.86 -67.58, -12.19 in-in in 8.305 Saltbr-in 2.573 HRD-in -72.29, -48.61 68.2, 11.99 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.81 APE8-rot-na 181.89 APE67-dihe-in -64.26, -21.67 -83.98, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.07 0.211 0.251 A 311 264 18 0 0 11 [[463, 721]] 1.0 4yff TKL_TNNI3K_HUMAN TKL 1.6e-77 266.7 1 267 267 605 606 607 609 611 490 509 513 585 587 586 588 647 634 629 628 627 626 625 624 623 540 Serine/threonine-protein kinase TNNI3K
TKL TNNI3K TNI3K_HUMAN 4YFFB Q59H18 445 726 835.0 4CV:801 Type1 None DFGin 6.848 13.882 BLAminus DFGAsp-rot-in -128.82, 174.1 57.67, 94.34 197.25, -9.76 -100.02, 21.13 285.48, 77.01 -67.5, -10.8 in-in in 8.358 Saltbr-in 2.603 HRD-in -72.09, -48.38 68.6, 12.37 in-in-none SNCiin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.74 APE8-rot-none 999.0 APE67-dihe-in -59.76, -26.5 -86.26, -18.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.07 0.211 0.251 B 311 264 18 0 0 12 [[463, 721]] 1.0 4yff TKL_TNNI3K_HUMAN TKL 1.6e-77 266.7 1 267 267 605 606 607 609 611 490 509 513 585 587 586 588 647 634 629 628 627 626 625 624 623 540 Serine/threonine-protein kinase TNNI3K
TKL TNNI3K TNI3K_HUMAN 6B5JB Q59H18 445 726 835.0 CV4:801 Type1 None DFGin 6.776 13.884 BLAminus DFGAsp-rot-in -127.39, 170.23 63.58, 89.42 196.19, -2.98 -96.67, 32.19 290.95, 72.96 -66.8, -26.81 in-in in 8.616 Saltbr-in 3.049 HRD-in -67.53, -48.98 70.48, -12.85 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.15 APE8-rot-na 200.19 APE67-dihe-in -61.72, -25.21 -84.18, -18.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.97 0.204 0.258 B 311 264 18 0 0 12 [[463, 721]] 1.0 6b5j TKL_TNNI3K_HUMAN TKL 1.6e-77 266.7 1 267 267 605 606 607 609 611 490 509 513 585 587 586 588 647 634 629 628 627 626 625 624 623 540 Serine/threonine-protein kinase TNNI3K
TYR CSK CSK_HUMAN 3D7UA P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.024 13.117 BLAminus DFGAsp-rot-in -139.73, -167.84 53.51, 74.77 198.83, -39.22 -92.77, 23.91 306.2, 90.91 -52.72, -52.05 in-in in 8.261 Saltbr-in 2.543 HRD-in -75.91, -39.41 59.37, 3.93 in-in-none SNCiin in-none ActLoopNT-in 2.903 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 146.18 APE9-dihe-in -90.57, 133.68 APE8-dihe-in -63.86, 107.61 APE8-rot-na 30.93 APE67-dihe-in -66.76, -13.54 -46.29, -47.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.896 APE9-dist-na 4.945 None None None XRAY 4.111 0.294 0.302 A 263 257 6 0 0 6 [[195, 442]] 1.0 3d7u TYR_CSK_HUMAN TYR 9.9e-88 299.8 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR CSK CSK_HUMAN 3D7UC P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.024 13.118 BLAminus DFGAsp-rot-in -139.69, -167.9 53.63, 74.8 198.79, -39.14 -92.81, 23.87 306.29, 90.94 -52.77, -51.99 in-in in 8.262 Saltbr-in 2.543 HRD-in -75.91, -39.47 59.39, 4.04 in-in-none SNCiin in-none ActLoopNT-in 2.905 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 146.11 APE9-dihe-in -90.53, 133.8 APE8-dihe-in -64.03, 107.64 APE8-rot-na 30.96 APE67-dihe-in -66.6, -13.57 -46.35, -47.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.897 APE9-dist-na 4.945 None None None XRAY 4.111 0.294 0.302 C 263 257 6 0 0 6 [[195, 442]] 1.0 3d7u TYR_CSK_HUMAN TYR 9.9e-88 299.8 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EGFR EGFR_HUMAN 2ITNA P00533 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.283 15.235 BLAminus DFGAsp-rot-in -127.19, -173.38 63.95, 79.84 214.57, -37.08 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.274 Saltbr-in 3.408 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.674 G719S None None XRAY 2.47 0.201 0.267 A 327 304 9 0 0 9 [[712, 970]] 1.0 2itn TYR_EGFR_HUMAN TYR 9.9e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITVA P00533 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.216 15.481 BLAminus DFGAsp-rot-in -132.41, -173.63 61.69, 81.35 197.88, 4.24 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.584 Saltbr-in 3.462 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.569 L858R None None XRAY 2.47 0.197 0.242 A 327 303 9 0 0 9 [[712, 970]] 1.0 2itv TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JX4A P00533 696 1018 1210.0 YY3:1101 Type1 None DFGin 6.538 15.295 BLAminus DFGAsp-rot-in -153.26, -174.41 59.27, 71.1 210.89, 73.12 -94.69, 11.38 288.28, 101.84 -61.51, -40.3 in-in in 8.089 Saltbr-in 3.167 HRD-in -72.1, -56.13 75.51, 1.81 in-in-none SNCiin in-none ActLoopNT-in 2.76 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 44.4 APE9-dihe-in -64.43, 143.52 APE8-dihe-in -93.62, 106.36 APE8-rot-na 34.75 APE67-dihe-in -65.07, -25.73 -81.11, -32.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.137 APE9-dist-na 7.793 T790M None None XRAY 2.531 0.213 0.245 A 331 315 8 0 0 8 [[712, 970]] 1.0 6jx4 TYR_EGFR_HUMAN TYR 8.6e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7VRAA P00533 696 1018 1210.0 I0A:1101 Type1 None DFGin 6.329 14.98 BLAminus DFGAsp-rot-in -141.39, -166.19 53.63, 67.86 201.93, -31.44 -86.81, 26.91 290.4, 77.76 -61.4, -34.62 in-in in 8.262 Saltbr-in 2.7 HRD-in -73.36, -43.6 68.83, -12.22 in-in-none SNCiin in-none ActLoopNT-in 2.816 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 128.24 APE9-dihe-in -138.53, 146.25 APE8-dihe-in -81.73, 106.37 APE8-rot-na 16.59 APE67-dihe-in -71.3, -8.33 -70.5, -37.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.507 APE9-dist-na 6.955 T790M,C797S None None XRAY 2.41 0.221 0.245 A 331 289 15 0 0 11 [[712, 970]] 1.0 7vra TYR_EGFR_HUMAN TYR 3.5e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7VREA P00533 696 1018 1210.0 7VH:1101 Type1 None DFGin 6.536 14.855 BLAminus DFGAsp-rot-in -135.27, -171.61 56.81, 74.8 201.97, -34.69 -92.4, 15.96 289.99, 73.74 -54.73, -16.72 in-in in 8.209 Saltbr-in 2.854 HRD-in -71.51, -50.16 76.97, -3.83 in-in-none SNCiin in-none ActLoopNT-in 2.785 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 43.94 APE9-dihe-in -79.86, 134.45 APE8-dihe-in -82.74, 99.99 APE8-rot-na 32.04 APE67-dihe-in -80.29, -2.71 -71.55, -29.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.336 APE9-dist-na 7.113 T790M,C797S None None XRAY 2.507 0.203 0.242 A 331 312 11 0 0 8 [[712, 970]] 1.0 7vre TYR_EGFR_HUMAN TYR 3.5e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9KLWA P00533 696 1019 1210.0 A1L53:61101 Type1 None DFGin 5.36 15.016 BLAminus DFGAsp-rot-in -137.92, -173.21 68.95, 86.53 203.41, -65.45 -103.04, 23.39 302.9, 100.52 -66.02, -20.59 in-in in 8.729 Saltbr-in 3.41 HRD-in -69.44, -47.22 66.72, 12.67 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.08 APE8-dihe-in -82.92, 74.1 APE8-rot-na 34.98 APE67-dihe-in -75.3, -8.48 -60.53, -40.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.69 T790M,L858R None None XRAY 2.67 0.2 0.257 A 330 298 14 0 0 13 [[712, 970]] 1.0 9klw TYR_EGFR_HUMAN TYR 8.9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2J5FA P00533 696 1020 1210.0 DJK:3021 Type1 None DFGin 5.657 14.384 BLAminus DFGAsp-rot-in -144.79, -170.55 64.0, 79.04 230.57, -89.08 -97.73, 24.0 296.97, 99.2 -43.96, -47.9 in-in in 8.267 Saltbr-in 2.813 HRD-in -61.54, -44.58 69.15, -3.0 in-in-none SNCiin in-none ActLoopNT-in 2.636 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 173.56 APE9-dihe-in -112.83, 120.26 APE8-dihe-in -93.5, 101.2 APE8-rot-na 33.0 APE67-dihe-in -64.88, -16.77 -72.19, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.227 APE9-dist-na 7.146 None None None XRAY 3.0 0.194 0.246 A 327 309 8 0 0 8 [[712, 970]] 1.0 2j5f TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6VHNA P00533 696 1019 1210.0 QQJ:1101 Type1 None DFGin 6.268 15.406 BLAminus DFGAsp-rot-in -137.01, -168.66 62.81, 80.02 205.49, -45.16 -103.64, 23.1 296.88, 98.97 -61.22, -32.89 in-in in 8.718 Saltbr-in 2.854 HRD-in -76.27, -52.37 76.32, -0.98 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.2 APE8-dihe-in -87.73, 89.87 APE8-rot-na 30.35 APE67-dihe-in -72.35, -2.54 -65.87, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.437 None None None XRAY 2.4 0.199 0.2 A 327 286 18 0 0 13 [[712, 970]] 1.0 6vhn TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6VHPA P00533 696 1019 1210.0 QP1:1101 Type1 None DFGin 6.015 15.357 BLAminus DFGAsp-rot-in -142.26, -172.24 60.71, 82.75 208.07, -49.09 -104.59, 30.45 301.25, 87.72 -60.33, -51.94 in-in in 8.978 Saltbr-in 2.908 HRD-in -76.89, -42.36 67.95, -9.7 in-in-none SNCiin in-none ActLoopNT-in 3.083 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 114.68 APE9-dihe-in -145.42, 154.51 APE8-dihe-in -84.79, 102.47 APE8-rot-na 20.66 APE67-dihe-in -73.32, -7.85 -65.47, -47.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.969 APE9-dist-na 6.918 None None None XRAY 3.6 0.184 0.218 A 327 308 5 0 0 5 [[712, 970]] 1.0 6vhp TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8G63A P00533 696 1017 1210.0 YXT:1101 Type1 None DFGin 5.529 14.747 BLAminus DFGAsp-rot-in -143.24, -159.19 52.58, 83.43 188.6, 54.71 -103.22, 21.32 305.76, 90.64 -45.28, -71.59 in-in in 8.933 Saltbr-in 2.765 HRD-in -81.87, -48.78 71.13, -4.89 in-in-none SNCiin in-none ActLoopNT-in 2.615 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 172.53 APE8-dihe-in -91.35, 75.86 APE8-rot-na 29.34 APE67-dihe-in -73.76, 1.1 -57.31, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.515 None None None XRAY 2.5 0.21 0.257 A 327 280 21 0 0 14 [[712, 970]] 1.0 8g63 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9DM8A P00533 696 1017 1210.0 A1A6K:1101 Type1 None DFGin 6.251 14.38 BLAminus DFGAsp-rot-in -129.4794, -169.6864 63.6629, 84.7768 196.5704, -11.0134 -102.6451, 27.7661 289.3356, 94.5342 -67.8271, -26.1337 in-in in 8.144 Saltbr-in 2.785 HRD-in -78.3814, -49.5717 72.7609, 1.2004 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 120.6585 APE9-dihe-in -135.8511, 150.669 APE8-dihe-in -78.3741, 83.2772 APE8-rot-na 33.5804 APE67-dihe-in -74.2341, -7.8324 -57.956, -39.3058 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.668 APE9-dist-na 6.851 None None None XRAY 2.13 0.21 0.214 A 327 287 15 0 0 9 [[712, 970]] 1.0 9dm8 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NGPA P00533 698 1018 1210.0 A1BX7:1101 Type1 None DFGin 6.167 14.553 BLAminus DFGAsp-rot-in -137.6061, -165.7411 59.368, 87.1237 201.0371, -20.9971 -103.844, 20.2902 290.0017, 98.7291 -66.9504, -6.6198 in-in in 8.088 Saltbr-in 2.592 HRD-in -79.9827, -46.422 69.693, 0.9105 in-in-none SNCiin in-none ActLoopNT-in 2.87 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 101.389 APE8-rot-na 32.6074 APE67-dihe-in -79.6247, -5.3085 -66.9439, -33.3886 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.4 0.209 0.238 A 327 281 18 0 0 14 [[712, 970]] 1.0 9ngp TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NHWA P00533 698 1017 1210.0 A1BYD:1101 Type1 None DFGin 6.053 15.233 BLAminus DFGAsp-rot-in -144.87, -175.31 63.29, 77.05 198.65, -34.83 -97.54, 24.54 296.32, 92.45 -60.8, -21.57 in-in in 8.651 Saltbr-in 2.717 HRD-in -72.16, -41.92 62.16, 7.57 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.95 APE8-dihe-in -67.02, 107.82 APE8-rot-na 338.68 APE67-dihe-in -78.27, -0.53 -71.56, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.576 None None None XRAY 2.73 0.239 0.268 A 327 280 18 0 0 8 [[712, 970]] 1.0 9nhw TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NISA P00533 696 1016 1210.0 A1BYK:1101 Type1 None DFGin 6.187 15.633 BLAminus DFGAsp-rot-in -132.6, -171.59 61.46, 82.06 204.14, -41.31 -102.11, 30.13 293.65, 92.81 -70.22, -9.04 in-in in 8.824 Saltbr-in 2.777 HRD-in -74.0, -46.82 70.75, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.962 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.12 APE8-dihe-in -77.06, 100.01 APE8-rot-na 28.66 APE67-dihe-in -74.77, -0.45 -66.74, -40.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.61 None None None XRAY 2.23 0.235 0.262 A 327 281 17 0 0 10 [[712, 970]] 1.0 9nis TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NJ7A P00533 698 1017 1210.0 A1BYL:1201 Type1 None DFGin 6.064 15.618 BLAminus DFGAsp-rot-in -139.58, -169.66 55.85, 84.13 202.41, -38.11 -103.94, 33.72 294.22, 89.03 -68.52, -21.81 in-in in 8.785 Saltbr-in 2.695 HRD-in -73.41, -43.75 67.32, 4.02 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.66 APE8-dihe-in -73.6, 99.04 APE8-rot-na 28.02 APE67-dihe-in -69.1, -11.18 -63.58, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.492 None None None XRAY 2.53 0.233 0.281 A 327 266 30 0 0 15 [[712, 970]] 1.0 9nj7 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NJNA P00533 698 1017 1210.0 A1BYS:1101 Type1 None DFGin 6.052 15.492 BLAminus DFGAsp-rot-in -138.03, -171.71 61.23, 82.93 202.08, -36.03 -102.84, 28.68 295.04, 92.18 -66.73, -16.96 in-in in 8.924 Saltbr-in 3.498 HRD-in -75.24, -45.9 66.95, 7.02 in-in-none SNCiin in-none ActLoopNT-in 2.929 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.33 APE8-dihe-in -71.72, 99.92 APE8-rot-na 26.75 APE67-dihe-in -76.44, 0.7 -63.78, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.484 None None None XRAY 2.24 0.242 0.275 A 327 268 28 0 0 13 [[712, 970]] 1.0 9njn TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NM0A P00533 697 1018 1210.0 VO7:1101 Type1 None DFGin 6.308 15.402 BLAminus DFGAsp-rot-in -140.17, -167.49 58.79, 90.01 221.52, -35.01 -111.11, 22.07 294.08, 94.65 -58.39, -24.66 in-in in 8.079 Saltbr-in 3.12 HRD-in -72.56, -49.62 74.29, -11.19 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 98.9 APE8-rot-na 32.89 APE67-dihe-in -82.2, -4.65 -68.26, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.59 0.209 0.247 A 327 273 27 0 0 16 [[712, 970]] 1.0 9nm0 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9OS6A P00533 697 1017 1210.0 A1CEA:1101 Type1 None DFGin 5.787 14.723 BLAminus DFGAsp-rot-in -149.68, -169.55 59.63, 82.89 203.29, -45.37 -107.09, 37.79 302.53, 107.91 -67.77, -19.45 in-in in 8.65 Saltbr-in 2.864 HRD-in -73.22, -47.28 69.98, 3.7 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.25 APE8-dihe-in -84.48, 84.59 APE8-rot-na 30.42 APE67-dihe-in -71.55, 6.59 -60.52, -46.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.437 None None None XRAY 2.75 0.211 0.255 A 327 277 22 0 0 14 [[712, 970]] 1.0 9os6 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9H46A P00533 696 1019 1210.0 A1ISA:1101 Type1 None DFGin 6.363 15.169 BLAminus DFGAsp-rot-in -149.47, -177.58 62.62, 58.11 238.48, 62.72 -90.1, 3.13 314.38, 111.86 -47.48, -44.04 in-in in 8.743 Saltbr-in 3.221 HRD-in -63.57, -45.69 65.43, -1.15 in-in-none SNCiin in-none ActLoopNT-in 2.657 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.98 APE8-dihe-in -85.78, 71.07 APE8-rot-na 35.5 APE67-dihe-in -68.16, -32.18 -60.78, -38.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.139 None None None XRAY 3.163 0.214 0.256 A 328 305 11 0 0 11 [[712, 970]] 1.0 9h46 TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7UKVA P00533 696 1018 1210.0 ZRT:1101 Type1 None DFGin 5.936 15.094 BLAminus DFGAsp-rot-in -138.2, -168.81 62.37, 83.02 221.86, -42.63 -103.85, 24.26 298.25, 88.25 -61.11, -23.87 in-in in 8.689 Saltbr-in 2.994 HRD-in -78.76, -49.38 70.66, 2.89 in-in-none SNCiin in-none ActLoopNT-in 2.973 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 127.73 APE9-dihe-in -144.8, 152.44 APE8-dihe-in -81.13, 94.3 APE8-rot-na 29.19 APE67-dihe-in -72.65, 4.24 -61.82, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.234 APE9-dist-na 6.419 None None None XRAY 2.4 0.213 0.243 A 328 290 13 0 0 6 [[712, 970]] 1.0 7ukv TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZAUA P00533 698 1017 1210.0 YY3:1101 Type1 None DFGin 6.017 15.47 BLAminus DFGAsp-rot-in -144.79, -170.19 56.78, 87.23 210.08, -37.44 -105.06, 22.23 291.67, 100.52 -61.25, -22.95 in-in in 9.092 Saltbr-in 3.506 HRD-in -80.01, -54.39 75.7, 11.54 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 172.16 APE9-dihe-in -149.48, 142.85 APE8-dihe-in -76.13, 94.93 APE8-rot-na 357.17 APE67-dihe-in -79.77, -9.04 -61.73, -40.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.194 APE9-dist-na 6.955 None None None XRAY 2.8 0.196 0.244 A 330 283 14 0 0 5 [[712, 970]] 1.0 4zau TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7B85A P00533 697 1020 1210.0 R28:1101 Type1 None DFGin 5.854 14.557 BLAminus DFGAsp-rot-in -137.84, -174.1 60.63, 85.07 202.25, -7.73 -103.17, 26.09 294.86, 88.23 -63.8, -24.92 in-in in 7.92 Saltbr-in 2.748 HRD-in -73.34, -48.14 69.22, 2.13 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 121.75 APE9-dihe-in -146.0, 163.38 APE8-dihe-in -89.43, 103.15 APE8-rot-na 22.0 APE67-dihe-in -71.22, -17.13 -66.77, -37.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.554 APE9-dist-na 6.798 None None None XRAY 2.5 0.216 0.244 A 333 312 6 0 0 2 [[712, 970]] 1.0 7b85 TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6S9BA P00533 697 1019 1210.0 L1H:1101 Type1 None DFGin 6.118 15.018 BLAminus DFGAsp-rot-in -148.24, -172.87 65.26, 88.24 211.07, -49.65 -111.59, 23.4 302.91, 91.25 -69.84, -29.04 in-in in 8.68 Saltbr-in 2.766 HRD-in -77.95, -44.62 67.36, 12.41 in-in-none SNCiin in-none ActLoopNT-in 2.789 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 130.6 APE9-dihe-in -136.99, 149.82 APE8-dihe-in -88.88, 86.38 APE8-rot-na 33.73 APE67-dihe-in -72.04, -14.11 -61.18, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.083 APE9-dist-na 7.2 T790M,L858R,E865A,E866A,K867A None None XRAY 3.25 0.186 0.232 A 326 291 15 0 0 12 [[712, 970]] 1.0 6s9b TYR_EGFR_HUMAN TYR 4.5e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6S9CA P00533 696 1019 1210.0 L1K:61101 Type1 None DFGin 5.825 14.722 BLAminus DFGAsp-rot-in -137.24, -177.45 69.22, 83.47 201.5, -39.64 -102.5, 27.64 296.66, 90.76 -71.56, -8.94 in-in in 8.526 Saltbr-in 2.833 HRD-in -60.53, -44.79 71.19, 1.46 in-in-none SNCiin in-none ActLoopNT-in 2.756 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 105.07 APE9-dihe-in -124.15, 154.71 APE8-dihe-in -82.6, 76.59 APE8-rot-na 34.11 APE67-dihe-in -73.9, -13.53 -58.44, -39.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.508 APE9-dist-na 7.756 T790M,L858R,E865A,E866A,K867A None None XRAY 2.73 0.202 0.225 A 329 299 14 0 0 12 [[712, 970]] 1.0 6s9c TYR_EGFR_HUMAN TYR 4.7e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ4A P00533 697 1018 1210.0 3QW:1101 Type1 None DFGin 5.642 14.869 BLAminus DFGAsp-rot-in -140.69, -172.61 68.51, 86.31 198.63, -70.82 -99.76, 22.2 296.02, 102.47 -65.67, -16.31 in-in in 8.584 Saltbr-in 2.803 HRD-in -56.37, -48.84 66.69, -1.93 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.29 APE8-dihe-in -86.76, 81.28 APE8-rot-na 21.53 APE67-dihe-in -69.94, -5.61 -53.89, -50.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.202 T790M,L858R,E865A,E866A,K867A None None XRAY 2.78 0.19 0.226 A 331 299 17 0 0 14 [[712, 970]] 1.0 4rj4 TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ7A P00533 697 1018 1210.0 3R1:1102 Type1 None DFGin 6.017 14.69 BLAminus DFGAsp-rot-in -136.51, -172.32 66.59, 81.87 198.8, 17.58 -97.51, 17.72 294.15, 102.13 -65.84, -16.96 in-in in 8.348 Saltbr-in 3.238 HRD-in -60.19, -50.96 69.31, -0.58 in-in-none SNCiin in-none ActLoopNT-in 2.741 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.16 APE8-dihe-in -78.25, 70.95 APE8-rot-na 29.95 APE67-dihe-in -67.71, -3.19 -45.43, -49.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.219 T790M,L858R,E865A,E866A,K867A None None XRAY 2.55 0.207 0.234 A 331 295 19 0 0 14 [[712, 970]] 1.0 4rj7 TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ8A P00533 697 1018 1210.0 3QS:1102 Type1 None DFGin 5.739 14.839 BLAminus DFGAsp-rot-in -139.18, -167.47 68.29, 77.56 215.62, -58.37 -89.12, 10.26 294.1, 106.72 -54.86, -20.91 in-in in 8.396 Saltbr-in 2.794 HRD-in -60.49, -55.01 73.42, -2.13 in-in-none SNCiin in-none ActLoopNT-in 2.781 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -86.58, 81.4 APE8-rot-na 26.4 APE67-dihe-in -68.07, -3.17 -48.59, -54.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.12 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.197 0.226 A 331 298 18 0 0 14 [[712, 970]] 1.0 4rj8 TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5C8KA P00533 697 1018 1210.0 4YV:1101 Type1 None DFGin 5.618 14.865 BLAminus DFGAsp-rot-in -142.56, -168.74 65.75, 82.14 215.39, -72.66 -97.63, 22.27 300.75, 101.92 -60.4, -26.09 in-in in 8.741 Saltbr-in 2.765 HRD-in -67.41, -39.79 60.89, -7.73 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -95.26, 73.85 APE8-rot-na 27.78 APE67-dihe-in -64.32, -5.28 -41.93, -56.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.159 T790M,L858R,E865A,E866A,K867A None None XRAY 3.0 0.202 0.251 A 331 300 17 0 0 15 [[712, 970]] 1.0 5c8k TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5C8MA P00533 697 1019 1210.0 4YW:1101 Type1 None DFGin 6.03 15.137 BLAminus DFGAsp-rot-in -139.93, -166.43 62.51, 82.79 209.75, -82.54 -104.18, 35.15 303.24, 104.63 -71.47, -7.58 in-in in 8.656 Saltbr-in 2.802 HRD-in -63.0, -55.16 74.91, -5.77 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.92 APE8-dihe-in -91.72, 83.46 APE8-rot-na 23.85 APE67-dihe-in -63.98, -6.63 -55.14, -47.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.308 T790M,L858R,E865A,E866A,K867A None None XRAY 2.9 0.21 0.252 A 331 302 16 0 0 14 [[712, 970]] 1.0 5c8m TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5C8NA P00533 696 1019 1210.0 4YX:1102 Type1 None DFGin 5.55 14.849 BLAminus DFGAsp-rot-in -130.09, -164.08 61.96, 83.03 194.52, -13.47 -95.79, 18.7 301.11, 101.32 -62.83, -10.09 in-in in 8.554 Saltbr-in 2.837 HRD-in -74.54, -49.37 73.34, -0.43 in-in-none SNCiin in-none ActLoopNT-in 2.861 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.63 APE8-dihe-in -90.67, 83.94 APE8-rot-na 35.45 APE67-dihe-in -71.85, 0.66 -67.76, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.237 T790M,L858R,E865A,E866A,K867A None None XRAY 2.401 0.204 0.258 A 331 300 17 0 0 14 [[712, 970]] 1.0 5c8n TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CALA P00533 697 1018 1210.0 4Z8:1101 Type1 None DFGin 5.497 14.495 BLAminus DFGAsp-rot-in -137.41, -172.89 65.78, 89.63 194.85, 14.87 -103.26, 18.8 297.84, 103.35 -65.07, -18.88 in-in in 8.735 Saltbr-in 2.949 HRD-in -63.06, -53.55 70.57, -1.46 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.13 APE8-dihe-in -87.57, 76.27 APE8-rot-na 28.21 APE67-dihe-in -69.94, -3.46 -48.77, -46.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.071 T790M,L858R,E865A,E866A,K867A None None XRAY 2.7 0.206 0.227 A 331 300 17 0 0 15 [[712, 970]] 1.0 5cal TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CANA P00533 696 1019 1210.0 4ZB:1102 Type1 None DFGin 5.619 14.735 BLAminus DFGAsp-rot-in -142.73, -174.9 68.91, 93.29 192.6, -65.49 -106.76, 21.14 296.79, 103.43 -65.99, -14.88 in-in in 8.569 Saltbr-in 2.838 HRD-in -62.3, -49.88 68.9, -1.6 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.26 APE8-dihe-in -87.26, 78.01 APE8-rot-na 20.78 APE67-dihe-in -67.65, -1.03 -49.32, -53.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.199 T790M,L858R,E865A,E866A,K867A None None XRAY 2.8 0.198 0.232 A 331 301 16 0 0 14 [[712, 970]] 1.0 5can TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAOA P00533 697 1019 1210.0 4ZG:1101 Type1 None DFGin 5.726 14.535 BLAminus DFGAsp-rot-in -132.0, -172.67 65.56, 80.31 197.46, 1.18 -104.95, 26.76 323.84, 105.62 -77.97, 14.2 in-in in 8.772 Saltbr-in 3.033 HRD-in -58.9, -58.41 76.18, -10.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.94 APE8-dihe-in -90.41, 73.41 APE8-rot-na 26.26 APE67-dihe-in -60.83, -6.66 -44.66, -55.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.42 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.203 0.231 A 331 300 19 0 0 16 [[712, 970]] 1.0 5cao TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAPA P00533 697 1019 1210.0 4ZH:1103 Type1 None DFGin 5.965 15.081 BLAminus DFGAsp-rot-in -134.45, -171.01 71.99, 88.37 206.45, 13.22 -110.44, 24.81 303.88, 121.07 -72.28, -6.86 in-in in 8.389 Saltbr-in 2.786 HRD-in -63.56, -57.8 76.6, -10.03 in-in-none SNCiin in-none ActLoopNT-in 3.14 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.82 APE8-dihe-in -83.94, 76.0 APE8-rot-na 26.21 APE67-dihe-in -67.04, -0.42 -50.69, -48.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.483 T790M,L858R,E865A,E866A,K867A None None XRAY 2.4 0.191 0.213 A 331 303 15 0 0 15 [[712, 970]] 1.0 5cap TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5EM7A P00533 696 1019 1210.0 5Q4:1102 Type1 None DFGin 6.063 14.737 BLAminus DFGAsp-rot-in -135.51, -175.43 63.24, 90.16 193.12, -71.34 -107.26, 25.15 291.83, 97.24 -73.87, -13.09 in-in in 8.193 Saltbr-in 2.807 HRD-in -60.94, -47.98 66.46, -2.63 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.59 APE8-dihe-in -87.95, 81.76 APE8-rot-na 24.14 APE67-dihe-in -66.12, -4.01 -54.22, -49.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.23 T790M,L858R,E865A,E866A,K867A None None XRAY 2.81 0.19 0.216 A 331 300 17 0 0 14 [[712, 970]] 1.0 5em7 TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HCXA P00533 696 1018 1210.0 60B:1102 Type1 None DFGin 5.679 14.34 BLAminus DFGAsp-rot-in -134.75, -168.37 67.26, 84.11 208.87, -44.81 -97.03, 11.58 292.78, 109.41 -56.16, -12.04 in-in in 8.197 Saltbr-in 3.182 HRD-in -55.82, -53.35 72.1, 1.2 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.91 APE8-dihe-in -89.45, 69.04 APE8-rot-na 28.83 APE67-dihe-in -67.35, -11.16 -46.21, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.3 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.194 0.223 A 331 298 17 0 0 14 [[712, 970]] 1.0 5hcx TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HCZA P00533 696 1019 1210.0 60E:1102 Type1 None DFGin 5.51 14.126 BLAminus DFGAsp-rot-in -138.48, -168.94 67.59, 84.64 207.01, -18.01 -98.68, 22.07 297.97, 107.23 -59.74, -32.24 in-in in 8.208 Saltbr-in 2.979 HRD-in -55.25, -49.19 68.73, 4.6 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.77 APE8-dihe-in -87.19, 65.54 APE8-rot-na 27.65 APE67-dihe-in -64.96, -12.37 -40.06, -51.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.324 T790M,L858R,E865A,E866A,K867A None None XRAY 2.62 0.196 0.227 A 331 300 17 0 0 14 [[712, 970]] 1.0 5hcz TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITTA P00533 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.936 14.965 BLAminus DFGAsp-rot-in -130.73, -162.83 54.09, 78.3 217.4, -56.39 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.368 Saltbr-in 2.867 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.493 L858R None None XRAY 2.73 0.212 0.262 A 327 302 9 0 0 9 [[712, 970]] 1.0 2itt TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X26A P00533 697 1020 1210.0 7XO:1101 Type1 None DFGin 6.188 14.935 BLAminus DFGAsp-rot-in -153.57, -170.14 58.63, 70.59 228.77, 80.67 -94.54, 18.38 292.51, 110.93 -60.72, -39.59 in-in in 8.548 Saltbr-in 3.317 HRD-in -64.24, -45.47 69.82, 6.31 in-in-none SNCiin in-none ActLoopNT-in 2.835 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.99 APE8-dihe-in -94.19, 95.15 APE8-rot-na 32.94 APE67-dihe-in -63.12, -36.92 -65.94, -42.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.448 L858R None None XRAY 2.951 0.197 0.222 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x26 TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X27A P00533 697 1020 1210.0 7XR:1101 Type1 None DFGin 6.089 14.567 BLAminus DFGAsp-rot-in -142.52, -171.15 59.08, 68.89 229.26, -83.61 -91.56, 16.87 296.22, 103.35 -59.61, -40.88 in-in in 8.476 Saltbr-in 3.407 HRD-in -67.74, -41.55 62.13, 9.32 in-in-none SNCiin in-none ActLoopNT-in 2.795 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.75 APE8-dihe-in -94.41, 99.92 APE8-rot-na 33.71 APE67-dihe-in -62.5, -41.39 -64.95, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.156 L858R None None XRAY 2.952 0.205 0.238 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x27 TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X28A P00533 697 1020 1210.0 7XU:1101 Type1 None DFGin 6.242 14.981 BLAminus DFGAsp-rot-in -155.25, -168.54 56.92, 67.25 226.27, -88.21 -92.6, 16.38 291.1, 113.77 -60.0, -38.56 in-in in 8.766 Saltbr-in 2.872 HRD-in -64.09, -44.41 72.37, 3.05 in-in-none SNCiin in-none ActLoopNT-in 2.907 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.7 APE8-dihe-in -90.21, 91.04 APE8-rot-na 33.64 APE67-dihe-in -63.4, -43.04 -64.77, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.502 L858R None None XRAY 2.952 0.211 0.25 A 327 310 9 0 0 9 [[712, 970]] 1.0 5x28 TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5XDLA P00533 696 1018 1210.0 8JC:1101 Type1 None DFGin 6.15 14.871 BLAminus DFGAsp-rot-in -146.3, -172.59 64.93, 71.28 209.97, -63.36 -94.1, 9.83 302.09, 99.18 -52.93, -42.05 in-in in 8.394 Saltbr-in 3.228 HRD-in -74.03, -53.77 76.73, 1.67 in-in-none SNCiin in-none ActLoopNT-in 3.156 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 59.31 APE8-rot-na 32.98 APE67-dihe-in -74.19, -13.64 -84.48, -30.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L858R None None XRAY 2.7 0.212 0.256 A 331 292 17 0 0 15 [[712, 970]] 1.0 5xdl TYR_EGFR_HUMAN TYR 1.2e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9U8CD P00533 696 987 1210.0 A1L8T:61101 Type1 None DFGin 5.518 14.842 BLAminus DFGAsp-rot-in -152.89, -164.88 57.37, 59.02 209.68, -58.73 -76.65, 17.66 286.7, 98.09 -55.38, -41.88 in-in in 8.871 Saltbr-in 3.187 HRD-in -114.09, -29.54 63.53, -55.66 in-in-none SNCiin in-none ActLoopNT-in 3.462 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.4 APE8-dihe-in -82.7, 101.15 APE8-rot-na 29.1 APE67-dihe-in -63.15, -43.97 -69.62, -36.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.518 None None None XRAY 3.5 0.275 0.3 D 338 285 7 0 0 4 [[712, 970]] 1.0 9u8c TYR_EGFR_HUMAN TYR 1.8e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6D8EA P00533 696 1019 1210.0 FZP:1101 Type1.5_Back None DFGin 6.042 15.059 BLAminus DFGAsp-rot-in -138.11, -172.24 64.79, 63.43 232.55, 89.87 -86.6, 14.58 312.63, 81.25 -43.94, -59.79 in-in in 8.652 Saltbr-in 2.645 HRD-in -72.15, -45.77 63.05, 4.69 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 112.81 APE9-dihe-in -139.79, 164.58 APE8-dihe-in -99.25, 105.5 APE8-rot-na 28.33 APE67-dihe-in -68.5, -6.69 -82.32, -41.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.866 APE9-dist-na 7.175 None None None XRAY 2.537 0.212 0.243 A 327 304 9 0 0 5 [[712, 970]] 1.0 6d8e TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ5A P00533 697 1019 1210.0 3QY:1101 Type1.5_Back None DFGin 6.144 15.305 BLAminus DFGAsp-rot-in -139.13, -172.0 64.67, 84.34 208.92, 83.41 -102.51, 37.37 294.94, 103.28 -69.92, -22.45 in-in in 8.602 Saltbr-in 2.803 HRD-in -64.72, -40.04 62.76, -16.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.1 APE8-dihe-in -84.86, 78.78 APE8-rot-na 27.08 APE67-dihe-in -69.19, -9.72 -53.68, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.385 T790M,L858R,E865A,E866A,K867A None None XRAY 3.1 0.195 0.229 A 331 296 20 0 0 16 [[712, 970]] 1.0 4rj5 TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAQA P00533 697 1018 1210.0 4ZJ:1102 Type1.5_Back None DFGin 5.668 14.915 BLAminus DFGAsp-rot-in -137.02, -170.07 67.33, 79.05 213.24, -44.82 -91.72, 13.18 294.21, 102.26 -60.56, -10.03 in-in in 8.672 Saltbr-in 2.802 HRD-in -60.07, -52.9 72.53, 1.36 in-in-none SNCiin in-none ActLoopNT-in 2.794 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.08 APE8-dihe-in -79.35, 76.04 APE8-rot-na 30.69 APE67-dihe-in -65.52, -10.47 -45.15, -52.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.989 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.185 0.224 A 331 301 16 0 0 14 [[712, 970]] 1.0 5caq TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CASA P00533 696 1019 1210.0 4ZQ:1102 Type1.5_Back None DFGin 5.648 14.99 BLAminus DFGAsp-rot-in -138.57, -167.77 68.04, 80.06 206.64, -33.13 -91.6, 15.8 296.16, 107.26 -57.65, -21.97 in-in in 8.912 Saltbr-in 2.832 HRD-in -67.55, -52.18 71.84, 1.99 in-in-none SNCiin in-none ActLoopNT-in 2.788 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.6 APE8-dihe-in -82.22, 70.93 APE8-rot-na 30.15 APE67-dihe-in -66.03, -7.47 -43.73, -55.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.053 T790M,L858R,E865A,E866A,K867A None None XRAY 2.1 0.184 0.209 A 331 299 17 0 0 13 [[712, 970]] 1.0 5cas TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAUA P00533 696 1018 1210.0 4ZR:1102 Type1.5_Back None DFGin 5.613 14.906 BLAminus DFGAsp-rot-in -141.53, -166.31 67.78, 77.4 210.44, -43.04 -89.35, 12.82 295.09, 107.73 -56.63, -14.57 in-in in 8.802 Saltbr-in 2.786 HRD-in -63.68, -54.38 71.77, 1.7 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.07 APE8-dihe-in -84.23, 76.34 APE8-rot-na 31.68 APE67-dihe-in -64.39, -7.38 -48.76, -54.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.158 T790M,L858R,E865A,E866A,K867A None None XRAY 2.25 0.188 0.211 A 331 297 18 0 0 14 [[712, 970]] 1.0 5cau TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HCYA P00533 696 1019 1210.0 60D:1102 Type1.5_Back None DFGin 5.564 14.343 BLAminus DFGAsp-rot-in -135.17, -165.75 65.93, 78.25 202.31, -25.32 -91.02, 13.27 295.4, 107.72 -55.11, -21.47 in-in in 8.422 Saltbr-in 2.796 HRD-in -60.52, -51.07 73.09, 1.44 in-in-none SNCiin in-none ActLoopNT-in 2.793 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.03 APE8-dihe-in -85.54, 71.02 APE8-rot-na 32.48 APE67-dihe-in -70.08, -5.63 -50.19, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.509 T790M,L858R,E865A,E866A,K867A None None XRAY 2.46 0.178 0.221 A 331 302 15 0 0 13 [[712, 970]] 1.0 5hcy TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HICA P00533 697 1019 1210.0 63N:1102 Type1.5_Back None DFGin 5.647 14.297 BLAminus DFGAsp-rot-in -139.13, -164.08 62.52, 78.14 206.43, -34.52 -92.5, 16.36 295.34, 105.72 -61.37, -14.82 in-in in 8.313 Saltbr-in 3.06 HRD-in -60.28, -47.26 67.03, 5.82 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.05 APE8-dihe-in -87.68, 72.67 APE8-rot-na 27.72 APE67-dihe-in -63.88, -10.28 -48.63, -51.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.353 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.191 0.233 A 331 302 16 0 0 14 [[712, 970]] 1.0 5hic TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 5I9VA P29317 605 896 976.0 AGS:1001 ATPlike None DFGin 5.797 14.921 BLAminus DFGAsp-rot-in -141.81, -171.65 57.06, 75.11 198.09, -10.46 -93.17, 20.3 299.55, 97.8 -61.14, -30.9 in-in in 8.619 Saltbr-in 2.822 HRD-in -77.85, -47.75 76.63, -12.15 in-in-none SNCiin in-none ActLoopNT-in 2.918 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 136.3 APE9-dihe-in -111.36, 131.85 APE8-dihe-in -64.26, 123.12 APE8-rot-na 332.19 APE67-dihe-in -77.38, -2.66 -54.41, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.712 APE9-dist-na 5.342 None None None XRAY 1.458 0.164 0.191 A 306 279 13 0 0 13 [[613, 873]] 1.0 5i9v TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 1MQBB P29317 602 883 976.0 ANP:1001 ATPlike None DFGin 5.691 14.889 BLAminus DFGAsp-rot-in -139.65, -173.77 51.28, 81.33 200.75, -3.37 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.273 Saltbr-in 2.64 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.328 APE9-dist-na 6.633 None None None XRAY 2.3 0.237 0.288 B 333 265 17 0 0 13 [[613, 873]] 1.0 1mqb TYR_EPHA2_HUMAN TYR 7.7e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJAB P29317 590 965 976.0 ACP:61003 ATPlike None DFGin 5.95 15.319 BLAminus DFGAsp-rot-in -132.83, -173.32 70.39, 83.56 194.46, 9.79 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.607 Saltbr-in 3.165 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.75 0.19 0.217 B 390 349 22 0 0 20 [[613, 873]] 1.0 7kja TYR_EPHA2_HUMAN TYR 1.3e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5IA0A P29317 604 889 976.0 A5B:1001 Type1 None DFGin 5.75 15.225 BLAminus DFGAsp-rot-in -131.01, -155.76 61.65, 69.41 182.46, 57.88 -104.69, 91.97 299.22, 100.6 -172.83, 999.0 in-in in 7.988 Saltbr-in 3.057 HRD-in -80.45, -46.02 73.5, -13.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.13 APE8-dihe-in -95.39, 103.1 APE8-rot-na 22.72 APE67-dihe-in -72.64, -3.49 -61.44, -50.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.638 None None None XRAY 1.948 0.194 0.225 A 306 263 23 0 0 19 [[613, 873]] 1.0 5ia0 TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5NKAA P29317 605 895 976.0 91H:1001 Type1 None DFGin 5.817 15.43 BLAminus DFGAsp-rot-in -138.05, -167.81 59.6, 76.5 218.06, -52.73 -90.38, 23.3 298.3, 92.95 -114.03, 999.0 in-in in 8.742 Saltbr-in 3.565 HRD-in -74.33, -47.29 74.19, -12.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -56.83 APE9-dihe-in -63.62, 121.18 APE8-dihe-in -54.7, 111.87 APE8-rot-na 330.09 APE67-dihe-in -75.86, -5.14 -47.88, -45.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.701 None None None XRAY 1.377 0.161 0.182 A 306 271 18 0 0 18 [[613, 873]] 1.0 5nka TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 6FNHC P29317 600 890 976.0 DXK:1001 Type1 None DFGin 6.1 15.078 BLAminus DFGAsp-rot-in -136.98, -166.98 54.47, 77.28 196.09, -36.67 -106.75, 37.52 303.15, 87.48 -109.85, 171.74 in-in in 8.523 Saltbr-in 2.973 HRD-in -71.56, -48.37 75.35, -10.7 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.12 APE8-rot-na 34.55 APE67-dihe-in -53.44, -22.38 -49.0, -43.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.379 0.206 0.221 C 306 270 21 0 0 19 [[613, 873]] 1.0 6fnh TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOQA P29320 595 906 983.0 ANP:948 ATPlike None DFGin 5.36 15.575 BLAminus DFGAsp-rot-in -132.4, -170.9 64.35, 72.55 182.94, 46.73 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.635 Saltbr-in 2.727 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.743 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373 285 18 0 0 18 [[621, 880]] 1.0 2qoq TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2GSFA P29320 595 904 983.0 No_ligand No_ligand None DFGin 5.349 15.927 BLAminus DFGAsp-rot-in -131.51, -172.61 60.33, 76.56 199.71, -17.47 -88.59, 16.43 293.13, 100.05 -68.35, -25.64 in-in in 8.866 Saltbr-in 2.652 HRD-in -71.12, -50.16 76.26, -12.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.12 APE8-rot-na 32.33 APE67-dihe-in -59.76, -26.04 -51.66, -46.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 A608T None None XRAY 1.77 0.16 0.195 A 373 281 16 0 0 16 [[621, 880]] 1.0 2gsf TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOKA P29320 595 904 983.0 No_ligand No_ligand None DFGin 5.347 15.982 BLAminus DFGAsp-rot-in -129.42, -174.51 59.36, 78.84 203.91, -30.91 -100.22, 55.36 291.83, 96.7 -103.96, -34.04 in-in in 8.81 Saltbr-in 2.76 HRD-in -71.78, -47.74 73.73, -11.15 in-in-none SNCiin in-none ActLoopNT-in 3.035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 55.48 APE8-dihe-in -87.96, 87.99 APE8-rot-na 33.99 APE67-dihe-in -60.98, -24.84 -56.01, -43.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.629 Y596F,Y602F,S768A None None XRAY 1.2 0.192 0.212 A 373 281 15 0 0 15 [[621, 880]] 1.0 2qok TYR_EPHA3_HUMAN TYR 1.2e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4GK3A P29320 609 903 983.0 L87:1001 Type1 None DFGin 5.139 14.807 BLAminus DFGAsp-rot-in -128.6, -167.12 48.3, 97.81 196.16, -22.72 -109.44, 24.03 294.5, 89.74 -59.07, -35.31 in-in in 8.501 Saltbr-in 2.722 HRD-in -73.64, -49.53 73.8, -7.65 in-in-none SNCiin in-none ActLoopNT-in 3.009 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.11 APE8-dihe-in -78.03, 100.04 APE8-rot-na 30.24 APE67-dihe-in -60.07, -23.79 -51.41, -46.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.718 None None None XRAY 1.898 0.18 0.213 A 361 275 14 0 0 14 [[621, 880]] 1.0 4gk3 TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4P5QA P29320 609 904 983.0 Q0B:1001 Type1 None DFGin 5.364 15.215 BLAminus DFGAsp-rot-in -132.21, -177.08 65.28, 76.17 177.61, 38.05 -99.61, 30.73 291.45, 96.46 -83.91, -18.12 in-in in 8.287 Saltbr-in 3.266 HRD-in -71.43, -46.81 71.58, -8.33 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.01 APE8-dihe-in -79.2, 95.75 APE8-rot-na 30.23 APE67-dihe-in -60.52, -25.3 -53.27, -46.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.974 None None None XRAY 1.35 0.158 0.182 A 361 275 16 0 0 16 [[621, 880]] 1.0 4p5q TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4TWOA P29320 609 906 983.0 37W:1001 Type1 None DFGin 5.261 14.863 BLAminus DFGAsp-rot-in -137.23, -171.69 56.38, 84.7 201.36, -86.31 -101.99, 32.13 298.62, 95.53 -60.78, -52.61 in-in in 8.171 Saltbr-in 3.147 HRD-in -68.52, -51.72 76.5, -11.58 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 87.71 APE8-rot-na 30.54 APE67-dihe-in -57.89, -27.69 -50.33, -47.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.047 0.165 0.201 A 361 278 15 0 0 15 [[621, 880]] 1.0 4two TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4G2FA P29320 609 903 983.0 C07:1001 Type1.5_Back None DFGin 5.45 14.73 BLAminus DFGAsp-rot-in -131.64, -174.37 59.7, 79.41 182.01, 50.07 -98.99, 31.81 296.97, 96.01 -73.91, -33.0 in-in in 8.217 Saltbr-in 2.799 HRD-in -73.48, -46.44 72.16, -6.7 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 96.83 APE8-rot-na 28.88 APE67-dihe-in -63.99, -23.43 -56.19, -41.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.699 0.18 0.208 A 361 275 15 0 0 15 [[621, 880]] 1.0 4g2f TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4GK2A P29320 609 903 983.0 L66:1001 Type1.5_Back None DFGin 5.393 14.345 BLAminus DFGAsp-rot-in -141.54, -172.14 65.23, 79.03 185.39, -84.84 -100.69, 30.27 304.12, 98.46 -69.06, -39.74 in-in in 7.956 Saltbr-in 2.511 HRD-in -70.13, -49.29 72.76, -10.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.91 APE8-rot-na 28.95 APE67-dihe-in -60.83, -25.11 -56.53, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.195 0.193 0.236 A 361 265 19 0 0 19 [[621, 880]] 1.0 4gk2 TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4GK4A P29320 609 903 983.0 L90:1001 Type1.5_Back None DFGin 5.006 14.462 BLAminus DFGAsp-rot-in -141.92, -169.06 54.42, 84.57 192.84, -13.37 -99.59, 22.26 304.42, 95.75 -54.8, -38.22 in-in in 8.552 Saltbr-in 3.151 HRD-in -68.01, -52.25 74.92, -3.22 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -110.32 APE9-dihe-in -98.4, 140.84 APE8-dihe-in -76.92, 99.05 APE8-rot-na 30.32 APE67-dihe-in -60.09, -27.75 -52.08, -44.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.922 APE9-dist-na 5.745 None None None XRAY 2.1 0.176 0.226 A 361 275 13 0 0 13 [[621, 880]] 1.0 4gk4 TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA7 EPHA7_HUMAN 7EEDA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 5.615 15.231 BLAminus DFGAsp-rot-in -160.14, -166.28 43.23, 89.72 202.64, -81.96 -111.48, -20.96 267.38, 102.35 -54.62, 166.76 in-in in 7.54 Saltbr-in 2.797 HRD-in -78.26, -42.61 76.57, -37.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.25 APE8-rot-na 338.3 APE67-dihe-in -74.18, -6.71 -44.02, -59.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D751H None None XRAY 3.05 0.201 0.247 A 304 275 18 0 0 18 [[633, 892]] 1.0 7eed TYR_EPHA7_HUMAN TYR 2.4e-109 370.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
TYR EPHA7 EPHA7_HUMAN 2REIA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 5.726 14.648 BLAminus DFGAsp-rot-in -132.78, -176.46 70.06, 80.71 178.47, 48.35 -109.81, 15.52 296.72, 101.1 -73.37, 178.43 in-in in 7.787 Saltbr-in 2.792 HRD-in -77.06, -49.41 79.73, -27.49 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.44 APE8-rot-na 327.54 APE67-dihe-in -71.85, -8.27 -50.21, -50.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.6 0.164 0.187 A 318 274 19 0 0 19 [[633, 892]] 1.0 2rei TYR_EPHA7_HUMAN TYR 2.1e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
TYR EPHA7 EPHA7_HUMAN 7EECA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 4.921 14.381 BLAminus DFGAsp-rot-in -139.59, -159.42 45.62, 100.81 165.98, 66.24 -122.34, 29.16 288.48, 121.6 -110.62, -128.85 in-in in 7.604 Saltbr-in 3.2 HRD-in -65.62, -46.05 82.26, -52.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.96 APE8-rot-na 42.57 APE67-dihe-in -71.92, -1.3 -56.97, -50.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 G656R None None XRAY 3.1 0.183 0.21 A 305 274 19 0 0 19 [[633, 892]] 1.0 7eec TYR_EPHA7_HUMAN TYR 2.1e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
TYR EPHA8 EPHA8_HUMAN 3KULA P29322 627 900 1005.0 No_ligand No_ligand None DFGin 6.33 13.426 BLAminus DFGAsp-rot-in -132.25, 178.69 63.32, 84.46 202.12, -17.61 -103.71, 28.05 296.17, 106.15 -76.22, -31.33 in-in in 8.865 Saltbr-in 2.319 HRD-in -84.23, -53.19 81.45, -9.81 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.1 APE8-dihe-in -72.66, 90.4 APE8-rot-na 22.79 APE67-dihe-in -74.46, -16.08 -47.23, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.844 None None None XRAY 2.15 0.19 0.244 A 325 267 7 0 0 7 [[635, 894]] 1.0 3kul TYR_EPHA8_HUMAN TYR 1.3e-102 348.6 1 260 260 777 778 779 781 783 667 684 688 757 759 758 760 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
TYR EPHB1 EPHB1_HUMAN 3ZFXB P54762 611 892 984.0 No_ligand No_ligand None DFGin 5.817 14.513 BLAminus DFGAsp-rot-in -140.84, 175.74 70.16, 66.52 225.27, -65.4 -88.36, 22.51 296.61, 82.06 -65.86, -37.4 in-in in 8.361 Saltbr-in 2.745 HRD-in -73.6, -53.87 82.61, -12.27 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -68.46, -4.35 999.0, -41.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 B 298 254 28 0 0 18 [[619, 880]] 1.0 3zfx TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 3ZFXC P54762 614 892 984.0 No_ligand No_ligand None DFGin 5.738 14.561 BLAminus DFGAsp-rot-in -137.69, 173.75 69.1, 70.2 221.46, -51.65 -91.34, 24.03 296.14, 85.79 -69.43, -30.67 in-none in 8.387 Saltbr-none 999.0 HRD-in -72.86, -47.73 75.93, -10.98 none-in-none SNCnin in-none ActLoopNT-in 3.003 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 119.99 APE8-rot-na 23.72 APE67-dihe-in -76.29, 1.22 -135.32, -30.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 C 298 248 31 0 0 19 [[619, 880]] 1.0 3zfx TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 3ZFXF P54762 612 893 984.0 No_ligand No_ligand None DFGin 5.751 14.45 BLAminus DFGAsp-rot-in -141.17, 174.54 70.47, 73.51 215.14, -60.33 -96.07, 25.2 298.87, 86.22 -68.13, -33.68 in-none in 8.262 Saltbr-none 999.0 HRD-in -76.22, -51.77 80.7, -11.45 none-in-none SNCnin in-none ActLoopNT-in 2.908 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -75.22, -1.35 999.0, -38.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 F 298 254 28 0 0 18 [[619, 880]] 1.0 3zfx TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 3ZFXG P54762 611 892 984.0 No_ligand No_ligand None DFGin 5.718 14.52 BLAminus DFGAsp-rot-in -137.41, 174.48 70.94, 70.55 222.75, -46.96 -95.84, 25.71 297.3, 82.59 -71.73, -27.91 in-in in 8.36 Saltbr-in 2.761 HRD-in -75.32, -55.18 83.83, -8.92 in-in-none SNCiin in-none ActLoopNT-in 2.97 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -75.69, 3.79 999.0, -41.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 G 298 253 29 0 0 18 [[619, 880]] 1.0 3zfx TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 5MJAA P54762 609 892 984.0 7O3:901 Type1.5_Back None DFGin 5.88 13.902 BLAminus DFGAsp-rot-in -139.99, -175.99 56.55, 73.99 214.91, -63.63 -90.49, 10.93 298.25, 99.95 -50.92, -47.24 in-in in 7.881 Saltbr-in 2.793 HRD-in -76.83, -50.44 72.7, -6.85 in-in-none SNCiin in-none ActLoopNT-in 2.864 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.53 APE8-rot-na 25.39 APE67-dihe-in -70.7, -7.58 -41.98, -56.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR647,PTR778 PTR647,PTR778 XRAY 2.14 0.202 0.236 A 305 273 11 0 0 11 [[619, 880]] 1.0 5mja TYR_EPHB1_HUMAN TYR 5.5e-109 369.5 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB4 EPHB4_HUMAN 6FNLA P54760 607 888 987.0 No_ligand No_ligand None DFGin 5.878 15.674 BLAminus DFGAsp-rot-in -131.81, -173.59 71.94, 76.75 186.39, 27.63 -109.07, -10.52 295.76, 100.61 -115.48, 999.0 in-in in 8.17 Saltbr-in 3.201 HRD-in -75.8, -47.92 75.96, -12.97 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 41.74 APE9-dihe-in -75.1, 127.77 APE8-dihe-in -74.57, 87.67 APE8-rot-na 29.53 APE67-dihe-in -73.26, -6.87 -55.8, -49.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.634 Y774E,A803V,V870I None None XRAY 1.269 0.197 0.213 A 297 262 20 0 0 20 [[615, 876]] 1.0 6fnl TYR_EPHB4_HUMAN TYR 4.4e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWA P54760 609 888 987.0 STU:1889 Type1 None DFGin 6.122 14.359 BLAminus DFGAsp-rot-in -139.16, 174.72 57.83, 79.91 208.66, 1.0 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.796 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.292 APE9-dist-na 6.071 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298 270 10 0 0 6 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.7e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWB P54760 609 887 987.0 STU:1888 Type1 None DFGin 6.6 14.69 BLAminus DFGAsp-rot-in -136.46, 179.33 65.25, 57.03 196.98, -0.09 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.554 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298 252 27 0 0 21 [[615, 876]] 1.0 3zew TYR_EPHB4_HUMAN TYR 2.7e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FES FES_HUMAN 4E93A P07332 448 822 822.0 GUI:60901 Type1 None DFGin 7.239 15.206 BLAminus DFGAsp-rot-in -147.07, -173.8 68.79, 70.92 213.96, 0.15 -92.31, 15.15 286.08, 92.67 -61.32, -36.23 in-in in 8.156 Saltbr-in 2.815 HRD-in -75.42, -47.46 72.8, -15.51 in-in-none SNCiin in-none ActLoopNT-in 2.899 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -46.55 APE8-dihe-in -81.8, 74.32 APE8-rot-na 28.54 APE67-dihe-in -65.5, -10.65 -48.91, -48.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.576 None None None XRAY 1.84 0.189 0.238 A 377 359 14 0 0 14 [[561, 816]] 1.0 4e93 TYR_FES_HUMAN TYR 6.8e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR IGF1R IGF1R_HUMAN 3LVPD P08069 986 1285 1367.0 PDR:4 Type1 None DFGin 6.306 14.427 BLAminus DFGAsp-rot-in -106.91, 166.93 53.44, 123.0 177.8, -70.73 -131.84, 26.68 301.24, 78.21 -46.25, -39.95 in-in in 9.275 Saltbr-in 3.129 HRD-in -65.98, -38.21 59.59, -1.0 in-in-none SNCiin in-none ActLoopNT-in 2.829 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 78.94 APE8-dihe-in -74.27, 72.81 APE8-rot-na 31.79 APE67-dihe-in -58.26, -9.17 -42.05, -56.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.259 None None None XRAY 3.0 0.226 0.279 D 336 282 18 0 0 3 [[999, 1268]] 1.0 3lvp TYR_IGF1R_HUMAN TYR 2.7e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR ITK ITK_HUMAN 3QGYB Q08881 357 616 620.0 L7O:60001 Type1 None DFGin 6.848 14.057 BLAminus DFGAsp-rot-in -138.24, -166.58 61.2, 71.7 209.66, -57.09 -99.64, 31.78 306.13, 96.16 -71.38, 20.95 in-in in 8.191 Saltbr-in 2.851 HRD-in -62.69, -53.89 75.14, -0.93 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.56 APE8-rot-na 999.0 APE67-dihe-in -67.28, -16.11 -66.33, -15.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.208 0.247 B 286 244 16 0 0 16 [[363, 614]] 1.0 3qgy TYR_ITK_HUMAN TYR 1.4e-92 315.7 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK2-2 JAK2_HUMAN 4D1SA O60674 842 1130 1132.0 BJG:1141 Type1 None DFGin 6.153 14.03 BLAminus DFGAsp-rot-in -124.84, -163.04 46.78, 76.68 203.66, -23.61 -90.28, 22.64 295.97, 91.18 -59.77, -25.09 in-in in 8.462 Saltbr-in 2.749 HRD-in -72.78, -44.48 72.51, -0.35 in-in-none SNCiin in-none ActLoopNT-in 2.776 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.85 APE8-dihe-in -79.29, 70.09 APE8-rot-na 33.83 APE67-dihe-in -78.27, -2.32 -57.11, -28.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.736 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.66 0.205 0.231 A 298 282 7 0 0 5 [[545, 807], [849, 1125]] 2.0 4d1s TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5USYA O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.298 14.188 BLAminus DFGAsp-rot-in -130.23, -164.34 47.33, 79.32 181.61, 40.22 -93.1, 20.71 291.84, 98.58 -62.97, -21.55 in-in in 8.613 Saltbr-in 2.803 HRD-in -71.47, -46.11 68.35, -0.6 in-in-none SNCiin in-none ActLoopNT-in 2.735 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.57 APE8-dihe-in -78.81, 76.11 APE8-rot-na 30.98 APE67-dihe-in -83.0, 0.49 -61.55, -24.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.265 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 A 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5USYB O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.309 14.253 BLAminus DFGAsp-rot-in -121.96, -156.65 31.13, 87.35 219.52, -45.37 -93.3, 22.45 292.93, 84.2 -66.48, -18.97 in-in in 8.443 Saltbr-in 2.973 HRD-in -70.92, -45.61 67.52, 2.98 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.82 APE8-dihe-in -82.14, 78.44 APE8-rot-na 33.08 APE67-dihe-in -81.92, -0.91 -60.29, -26.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.406 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 B 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK3-2 JAK3_HUMAN 6HZVA P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.429 14.257 BLAminus DFGAsp-rot-in -133.87, 178.6 61.51, 90.4 201.64, -2.64 -109.85, 28.17 289.99, 77.52 -67.6, -31.52 in-in in 8.324 Saltbr-in 2.931 HRD-in -62.66, -43.13 71.32, -8.68 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 119.68 APE8-rot-na 14.07 APE67-dihe-in -79.55, -1.3 -80.03, -13.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 A 285 266 18 0 0 5 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6HZVB P52333 815 1099 1124.0 GYW:1101 Type1 None DFGin 6.194 14.214 BLAminus DFGAsp-rot-in -135.38, 176.48 64.47, 86.88 197.48, -16.4 -105.43, 20.89 286.69, 85.17 -66.35, -29.51 in-in in 8.149 Saltbr-in 2.826 HRD-in -61.18, -44.44 71.7, 4.93 in-in-none SNCiin in-none ActLoopNT-in 2.691 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 129.11 APE8-rot-na 330.57 APE67-dihe-in -79.98, -2.63 -77.74, -18.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 B 285 269 16 0 0 6 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6HZVC P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.477 14.272 BLAminus DFGAsp-rot-in -130.86, 179.06 58.44, 90.28 202.3, -19.99 -109.09, 23.07 290.05, 84.12 -62.59, -33.96 in-in in 8.091 Saltbr-in 2.809 HRD-in -69.82, -48.24 78.15, -8.29 in-in-none SNCiin in-none ActLoopNT-in 2.689 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -41.25 APE8-dihe-in -66.72, 131.5 APE8-rot-na 341.69 APE67-dihe-in -75.5, -7.29 -73.63, -18.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.346 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 C 285 265 19 0 0 5 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6HZVD P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.418 14.152 BLAminus DFGAsp-rot-in -133.07, -178.12 58.66, 85.08 198.36, -19.73 -104.02, 25.84 292.67, 81.24 -61.98, -32.78 in-in in 8.14 Saltbr-in 2.77 HRD-in -71.74, -43.92 75.22, -14.51 in-in-none SNCiin in-none ActLoopNT-in 2.708 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -35.5 APE8-dihe-in -66.27, 131.93 APE8-rot-na 340.52 APE67-dihe-in -79.97, 1.1 -77.2, -17.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.634 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 D 285 259 25 0 0 5 [[521, 779], [822, 1097]] 2.0 6hzv TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86A P52333 814 1098 1124.0 9YV:4000 Type1 None DFGin 6.508 14.233 BLAminus DFGAsp-rot-in -130.78, -178.04 55.33, 86.29 180.24, 75.51 -99.45, 24.99 285.64, 80.91 -59.45, -36.09 in-in in 8.361 Saltbr-in 2.72 HRD-in -61.74, -49.91 79.02, -19.05 in-in-none SNCiin in-none ActLoopNT-in 2.834 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -62.63 APE8-dihe-in -73.09, 69.06 APE8-rot-na 28.5 APE67-dihe-in -76.22, -6.14 -68.16, -24.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.326 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 A 287 271 14 0 0 5 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86B P52333 816 1098 1124.0 9YV:4000 Type1 None DFGin 6.572 14.126 BLAminus DFGAsp-rot-in -130.89, -177.7 55.33, 86.59 179.18, 76.38 -98.74, 23.53 285.65, 80.73 -58.36, -36.34 in-in in 8.175 Saltbr-in 2.781 HRD-in -61.09, -43.56 75.39, -22.05 in-in-none SNCiin in-none ActLoopNT-in 2.827 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-in -98.06, 144.28 APE8-rot-na 28.22 APE67-dihe-in -84.46, -5.87 -122.29, -17.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.756 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 B 287 269 14 0 0 5 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86C P52333 814 1099 1124.0 9YV:4000 Type1 None DFGin 6.507 14.111 BLAminus DFGAsp-rot-in -131.5, -178.51 55.57, 86.1 179.55, 76.28 -97.59, 23.31 285.7, 80.13 -57.67, -36.43 in-in in 8.165 Saltbr-in 2.94 HRD-in -62.63, -48.44 77.31, -20.33 in-in-none SNCiin in-none ActLoopNT-in 2.822 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -67.29 APE8-rot-na 15.79 APE67-dihe-in -70.13, -18.29 -58.03, -20.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 C 287 275 11 0 0 6 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86D P52333 814 1099 1124.0 9YV:4000 Type1 None DFGin 6.561 14.255 BLAminus DFGAsp-rot-in -130.88, -178.77 56.18, 85.97 180.61, 75.87 -99.02, 25.19 285.73, 80.24 -59.91, -34.36 in-in in 8.183 Saltbr-in 2.757 HRD-in -62.59, -49.55 78.85, -19.41 in-in-none SNCiin in-none ActLoopNT-in 2.814 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -64.08 APE8-dihe-in -73.59, 57.74 APE8-rot-na 27.09 APE67-dihe-in -73.08, -10.82 -59.31, -28.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.241 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 D 287 274 12 0 0 5 [[521, 779], [822, 1097]] 2.0 5w86 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6AAKD P52333 814 1098 1124.0 9T6:1201 Type1 None DFGin 6.331 14.138 BLAminus DFGAsp-rot-in -145.03, 168.99 56.55, 97.11 206.83, -32.59 -103.75, 32.24 293.47, 81.71 -62.01, -33.71 in-in in 8.018 Saltbr-in 2.856 HRD-in -76.49, -42.81 76.74, -36.27 in-in-none SNCiin in-none ActLoopNT-in 2.766 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 72.65 APE8-dihe-in -50.29, 134.06 APE8-rot-na 332.19 APE67-dihe-in -63.85, -16.03 -70.13, -20.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.384 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 D 287 268 17 0 0 5 [[521, 779], [822, 1097]] 2.0 6aak TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZC6B P52333 813 1100 1124.0 VFC:2103 Type1 None DFGin 6.218 14.046 BLAminus DFGAsp-rot-in -128.88, -176.96 59.69, 81.97 196.63, 0.21 -99.61, 22.0 289.18, 82.46 -63.53, -20.72 in-in in 8.209 Saltbr-in 2.799 HRD-in -71.31, -49.71 79.31, 3.34 in-in-none SNCiin in-none ActLoopNT-in 2.748 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 25.15 APE9-dihe-in -99.95, 171.81 APE8-dihe-in -50.02, 112.29 APE8-rot-na 325.04 APE67-dihe-in -73.29, -4.3 -58.87, -25.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.482 APE9-dist-na 6.84 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 B 288 278 10 0 0 4 [[521, 779], [822, 1097]] 2.0 3zc6 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZC6C P52333 814 1100 1124.0 VFC:2103 Type1 None DFGin 6.281 14.003 BLAminus DFGAsp-rot-in -123.64, -177.74 61.16, 80.91 190.44, 6.73 -97.9, 27.04 288.23, 77.53 -66.72, -26.1 in-in in 8.191 Saltbr-in 2.684 HRD-in -72.21, -46.31 77.05, -24.4 in-in-none SNCiin in-none ActLoopNT-in 2.761 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.85 APE8-dihe-in -77.18, 80.1 APE8-rot-na 33.09 APE67-dihe-in -76.9, -10.93 -67.13, -29.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.177 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 C 288 277 10 0 0 4 [[521, 779], [822, 1097]] 2.0 3zc6 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZC6D P52333 814 1100 1124.0 VFC:2103 Type1 None DFGin 6.315 14.132 BLAminus DFGAsp-rot-in -134.59, -176.68 59.2, 81.95 187.75, 9.76 -97.58, 24.75 285.45, 76.49 -66.73, -25.04 in-in in 8.057 Saltbr-in 2.742 HRD-in -74.86, -52.02 77.99, -12.75 in-in-none SNCiin in-none ActLoopNT-in 2.73 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.2 APE8-rot-na 32.25 APE67-dihe-in -80.63, -5.09 -78.85, -21.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 D 288 269 18 0 0 5 [[521, 779], [822, 1097]] 2.0 3zc6 TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZEPB P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.353 14.222 BLAminus DFGAsp-rot-in -142.2, 177.46 62.39, 84.45 191.4, 16.92 -101.38, 32.38 292.96, 77.07 -73.1, -37.75 in-in in 8.241 Saltbr-in 2.735 HRD-in -71.3, -45.86 73.98, -5.89 in-in-none SNCiin in-none ActLoopNT-in 2.769 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 174.81 APE8-dihe-in -59.17, 141.04 APE8-rot-na 332.8 APE67-dihe-in -80.76, -5.98 -67.68, -15.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.477 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 B 288 270 17 0 0 4 [[521, 779], [822, 1097]] 2.0 3zep TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZEPC P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.267 14.284 BLAminus DFGAsp-rot-in -143.3, 179.56 63.59, 86.35 197.11, -5.24 -106.32, 31.56 290.45, 75.82 -68.82, -32.0 in-in in 8.174 Saltbr-in 2.755 HRD-in -76.43, -48.0 76.34, -21.16 in-in-none SNCiin in-none ActLoopNT-in 2.714 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 45.01 APE9-dihe-in -93.38, 161.79 APE8-dihe-in -56.5, 116.98 APE8-rot-na 326.42 APE67-dihe-in -74.98, -4.7 -72.25, -13.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.729 APE9-dist-na 6.85 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 C 288 278 9 0 0 2 [[521, 779], [822, 1097]] 2.0 3zep TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZEPD P52333 814 1099 1124.0 1NX:2100 Type1 None DFGin 6.575 14.572 BLAminus DFGAsp-rot-in -134.12, 176.57 59.25, 80.73 193.6, 18.77 -100.38, 28.57 291.24, 76.13 -63.83, -42.01 in-in in 8.361 Saltbr-in 2.672 HRD-in -72.39, -47.07 79.2, -13.88 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 161.47 APE8-dihe-in -52.69, 138.76 APE8-rot-na 329.47 APE67-dihe-in -77.9, -7.22 -77.25, -13.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.556 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 D 288 274 12 0 0 3 [[521, 779], [822, 1097]] 2.0 3zep TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVD P52333 814 1100 1124.0 OV5:1201 Type1 None DFGin 6.421 14.258 BLAminus DFGAsp-rot-in -133.29, -179.06 58.4, 83.86 197.68, -4.58 -99.71, 22.65 285.23, 81.71 -62.49, -28.09 in-in in 8.298 Saltbr-in 2.672 HRD-in -64.99, -48.29 76.96, -0.25 in-in-none SNCiin in-none ActLoopNT-in 2.746 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.98 APE8-dihe-in -58.27, 129.89 APE8-rot-na 335.93 APE67-dihe-in -80.69, -3.3 -71.81, -12.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.468 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 D 291 272 15 0 0 5 [[521, 779], [822, 1097]] 2.0 7uyv TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5VO6A P52333 815 1099 1124.0 9J4:4000 Type1 None DFGin 6.559 13.748 BLAminus DFGAsp-rot-in -128.78, -173.97 61.05, 89.09 187.1, 11.21 -107.4, 19.66 285.17, 86.8 -68.24, -28.8 in-in in 7.512 Saltbr-in 2.911 HRD-in -75.3, -50.06 76.72, -16.95 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 135.66 APE8-rot-na 332.57 APE67-dihe-in -81.44, -5.82 -70.82, -9.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C1040S,C1048S None None XRAY 2.65 0.215 0.284 A 293 271 14 0 0 6 [[521, 779], [822, 1097]] 2.0 5vo6 TYR_JAK3-2_HUMAN TYR 2.2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6NY4A P52333 815 1099 1124.0 Z3A:4000 Type1 None DFGin 6.432 13.752 BLAminus DFGAsp-rot-in -130.0, -166.41 50.15, 85.44 190.23, 14.44 -100.28, 21.12 284.91, 84.56 -64.41, -23.36 in-in in 7.69 Saltbr-in 2.777 HRD-in -74.4, -47.07 70.71, -6.14 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -0.08 APE9-dihe-in -95.23, 160.07 APE8-dihe-in -49.81, 129.43 APE8-rot-na 333.86 APE67-dihe-in -73.45, 2.08 -64.08, -16.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.706 APE9-dist-na 7.095 C811S,C1040S,C1048S None None XRAY 2.33 0.216 0.241 A 293 277 8 0 0 4 [[521, 779], [822, 1097]] 2.0 6ny4 TYR_JAK3-2_HUMAN TYR 2.2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4V0GB P52333 816 1098 1124.0 G9B:2099 Type1 None DFGin 6.202 14.633 BLAminus DFGAsp-rot-in -137.8, -174.69 52.03, 76.68 199.98, -45.81 -96.09, 37.57 296.46, 78.81 -70.34, -40.16 in-in in 8.7 Saltbr-in 2.629 HRD-in -75.76, -37.0 67.95, -17.09 in-in-none SNCiin in-none ActLoopNT-in 2.824 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.69 APE8-rot-na 331.57 APE67-dihe-in -77.98, -0.68 -62.56, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 B 283 274 9 0 0 5 [[521, 779], [822, 1097]] 2.0 4v0g TYR_JAK3-2_HUMAN TYR 2.4e-81 278.9 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4V0GA P52333 817 1098 1124.0 G9B:2099 Type1 None DFGin 6.198 14.717 BLAminus DFGAsp-rot-in -144.75, -176.45 39.25, 85.88 184.86, 64.91 -90.52, 22.25 286.27, 74.42 -61.38, -18.98 in-in in 8.352 Saltbr-in 2.707 HRD-in -65.46, -44.14 69.1, 4.41 in-in-none SNCiin in-none ActLoopNT-in 2.85 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -33.75 APE8-rot-na 330.77 APE67-dihe-in -73.45, -1.83 -68.02, -39.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 A 283 269 13 0 0 4 [[521, 779], [822, 1097]] 2.0 4v0g TYR_JAK3-2_HUMAN TYR 2.4e-81 278.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4Z16A P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.693 14.535 BLAminus DFGAsp-rot-in -125.11, -170.67 46.31, 83.09 186.88, 60.08 -100.98, 26.25 290.17, 83.28 -67.99, -29.42 in-in in 8.347 Saltbr-in 2.834 HRD-in -67.29, -45.59 73.41, -19.17 in-in-none SNCiin in-none ActLoopNT-in 2.829 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 77.57 APE8-rot-na 328.09 APE67-dihe-in -74.64, -13.67 -80.93, -12.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 A 316 273 17 0 0 5 [[521, 779], [822, 1097]] 2.0 4z16 TYR_JAK3-2_HUMAN TYR 7.7e-81 277.2 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4Z16C P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.724 14.541 BLAminus DFGAsp-rot-in -124.89, -171.04 46.95, 83.36 186.69, 60.11 -101.0, 25.74 290.21, 83.17 -68.15, -28.94 in-in in 8.372 Saltbr-in 2.84 HRD-in -67.03, -45.78 73.53, -19.66 in-in-none SNCiin in-none ActLoopNT-in 2.788 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 38.92 APE8-rot-na 335.43 APE67-dihe-in -76.63, -13.6 -68.45, -18.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 C 316 273 17 0 0 5 [[521, 779], [822, 1097]] 2.0 4z16 TYR_JAK3-2_HUMAN TYR 7.7e-81 277.2 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4Z16D P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.688 14.567 BLAminus DFGAsp-rot-in -124.04, -170.5 45.94, 82.68 187.13, 61.58 -99.35, 24.89 290.17, 82.54 -66.47, -27.42 in-in in 8.393 Saltbr-in 2.875 HRD-in -67.23, -45.45 73.09, -20.62 in-in-none SNCiin in-none ActLoopNT-in 2.794 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 52.48 APE8-rot-na 345.61 APE67-dihe-in -77.91, -13.97 -72.79, -6.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 D 316 273 17 0 0 5 [[521, 779], [822, 1097]] 2.0 4z16 TYR_JAK3-2_HUMAN TYR 7.7e-81 277.2 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4QPSA P52333 814 1100 1124.0 37Q:1201 Type1 None DFGin 6.896 14.091 BLAminus DFGAsp-rot-in -130.94, -174.49 64.52, 86.82 194.65, 2.33 -104.86, 15.71 281.27, 81.21 -57.28, -32.23 in-in in 8.588 Saltbr-in 2.864 HRD-in -78.56, -46.33 74.55, -53.21 in-in-none SNCiin in-none ActLoopNT-in 2.801 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 149.07 APE8-rot-na 18.94 APE67-dihe-in -69.31, -9.6 -100.11, -5.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 A 293 270 17 0 0 6 [[521, 779], [822, 1097]] 2.0 4qps TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4QPSC P52333 814 1102 1124.0 37Q:1201 Type1 None DFGin 6.775 14.2 BLAminus DFGAsp-rot-in -137.32, -176.14 60.46, 91.64 189.65, 10.8 -108.44, 19.09 284.35, 76.96 -56.92, -26.19 in-in in 8.502 Saltbr-in 2.803 HRD-in -82.86, -44.58 73.92, -46.68 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.79 APE8-dihe-in -74.25, 110.88 APE8-rot-na 352.69 APE67-dihe-in -70.61, -6.19 -68.78, -23.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.991 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 C 293 276 13 0 0 5 [[521, 779], [822, 1097]] 2.0 4qps TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLAA P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.125 14.066 BLAminus DFGAsp-rot-in -126.69, -163.69 45.61, 84.37 192.89, 5.66 -97.16, 18.74 276.14, 73.33 -60.39, -30.05 in-in in 7.833 Saltbr-in 2.674 HRD-in -80.36, -50.35 74.06, -4.7 in-in-none SNCiin in-none ActLoopNT-in 2.749 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 115.39 APE9-dihe-in -100.65, 143.31 APE8-dihe-in -75.22, 92.35 APE8-rot-na 30.49 APE67-dihe-in -81.25, -0.82 -60.88, -31.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.679 APE9-dist-na 7.001 None None None XRAY 1.92 0.228 0.273 A 294 288 3 0 0 3 [[521, 779], [822, 1097]] 2.0 6gla TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLAB P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.135 14.037 BLAminus DFGAsp-rot-in -126.98, -166.17 47.87, 84.06 194.36, 7.9 -100.26, 19.16 275.64, 73.52 -60.46, -30.51 in-in in 7.831 Saltbr-in 2.67 HRD-in -83.39, -49.56 74.28, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.775 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 114.52 APE9-dihe-in -101.31, 145.02 APE8-dihe-in -77.95, 91.55 APE8-rot-na 29.11 APE67-dihe-in -79.72, -1.04 -62.76, -29.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.745 APE9-dist-na 6.966 None None None XRAY 1.92 0.228 0.273 B 294 286 5 0 0 3 [[521, 779], [822, 1097]] 2.0 6gla TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLBA P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.087 14.005 BLAminus DFGAsp-rot-in -127.29, -165.11 42.2, 80.94 195.48, 4.55 -98.99, 18.18 281.6, 72.22 -46.91, -40.63 in-in in 7.576 Saltbr-in 2.712 HRD-in -78.7, -52.76 77.75, 9.6 in-in-none SNCiin in-none ActLoopNT-in 2.734 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 129.22 APE9-dihe-in -106.96, 151.72 APE8-dihe-in -79.63, 91.52 APE8-rot-na 32.17 APE67-dihe-in -74.91, -5.23 -62.01, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.734 APE9-dist-na 6.727 None None None XRAY 2.0 0.236 0.29 A 294 288 3 0 0 3 [[521, 779], [822, 1097]] 2.0 6glb TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLBB P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.117 14.025 BLAminus DFGAsp-rot-in -125.81, -165.95 42.86, 80.87 197.67, 1.05 -97.87, 18.6 282.22, 74.99 -51.1, -37.8 in-in in 7.545 Saltbr-in 2.708 HRD-in -76.97, -51.62 77.21, 8.56 in-in-none SNCiin in-none ActLoopNT-in 2.757 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 130.97 APE9-dihe-in -105.16, 150.45 APE8-dihe-in -79.13, 89.35 APE8-rot-na 33.14 APE67-dihe-in -76.14, -3.82 -57.76, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.629 APE9-dist-na 6.704 None None None XRAY 2.0 0.236 0.29 B 294 288 3 0 0 3 [[521, 779], [822, 1097]] 2.0 6glb TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 9R5ZA P52333 822 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.132 14.001 BLAminus DFGAsp-rot-in -127.52, -161.85 48.17, 81.61 188.21, 1.17 -92.0, 24.85 277.91, 73.75 -73.44, -23.7 in-in in 7.668 Saltbr-in 2.768 HRD-in -79.16, -47.46 79.61, -35.13 in-in-none SNCiin in-none ActLoopNT-in 2.88 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.63 APE8-rot-na 20.77 APE67-dihe-in -76.47, -3.83 -62.4, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.8 0.239 0.289 A 294 258 22 0 0 5 [[521, 779], [822, 1097]] 2.0 9r5z TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 9R5ZB P52333 816 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.226 14.13 BLAminus DFGAsp-rot-in -127.35, -164.41 49.32, 77.12 194.05, 3.35 -91.09, 23.07 281.2, 72.28 -62.52, -23.26 in-in in 7.882 Saltbr-in 2.819 HRD-in -86.18, -46.89 79.27, -42.6 in-in-none SNCiin in-none ActLoopNT-in 2.875 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.25 APE8-rot-na 31.77 APE67-dihe-in -82.31, -0.99 -65.94, -24.16 APE12-dist-na 11.045 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.8 0.239 0.289 B 294 275 11 0 0 3 [[521, 779], [822, 1097]] 2.0 9r5z TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR KIT KIT_HUMAN 1PKGB P10721 566 929 976.0 ADP:1486 ATPlike None DFGin 6.537 13.819 BLAminus DFGAsp-rot-in -133.94, -165.75 57.9, 93.59 198.24, -19.36 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.934 Saltbr-in 2.915 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.888 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.765 APE9-dist-na 6.494 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329 279 27 0 0 13 [[589, 926]] 1.0 1pkg TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8PQBA P10721 567 931 976.0 9XO:61001 Type1 None DFGin 7.065 13.907 BLAminus DFGAsp-rot-in -125.03, 178.92 57.85, 86.74 200.5, -26.57 -99.85, 27.47 283.64, 67.72 -68.32, -23.51 in-in in 7.946 Saltbr-in 2.834 HRD-in -88.64, -44.33 73.75, -0.94 in-in-none SNCiin in-none ActLoopNT-in 2.88 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -36.37 APE9-dihe-in -123.05, 142.81 APE8-dihe-in -78.63, 73.9 APE8-rot-na 33.79 APE67-dihe-in -70.48, -9.16 -54.85, -42.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.094 APE9-dist-na 7.446 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.87 0.2 0.234 A 327 270 17 0 0 11 [[589, 926]] 1.0 8pqb TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8PQEB P10721 566 930 976.0 9WU:61001 Type1 None DFGin 7.234 14.115 BLAminus DFGAsp-rot-in -126.18, 173.65 61.69, 86.72 202.25, -9.26 -98.88, 21.32 288.15, 71.07 -45.22, -42.17 in-in in 8.62 Saltbr-in 3.312 HRD-in -77.31, -50.57 76.99, -5.36 in-in-none SNCiin in-none ActLoopNT-in 2.779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 124.75 APE9-dihe-in -123.1, 151.69 APE8-dihe-in -82.48, 77.97 APE8-rot-na 31.45 APE67-dihe-in -69.72, -10.62 -57.01, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.159 APE9-dist-na 7.513 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.216 0.256 B 327 274 13 0 0 13 [[589, 926]] 1.0 8pqe TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR PTK2 FAK1_HUMAN 6YVYB Q05397 415 686 1052.0 P1E:701 Type1 None DFGin 6.76 16.154 BLAminus DFGAsp-rot-in -125.37, -159.56 46.15, 75.22 187.83, 86.46 -98.8, 22.63 289.45, 61.98 -103.7, -1.46 in-in in 8.082 Saltbr-in 2.884 HRD-in -68.13, -50.71 78.23, -5.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.05 APE8-dihe-in -81.82, 62.53 APE8-rot-na 30.96 APE67-dihe-in -65.78, -13.58 -48.49, -45.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.28 None None None XRAY 1.918 0.215 0.235 B 282 257 15 0 0 15 [[422, 678]] 1.0 6yvy TYR_PTK2_HUMAN TYR 3.7e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SRC SRC_HUMAN 6E6EH P12931 261 536 536.0 HVY:601 Type1 None DFGin 7.029 15.265 BLAminus DFGAsp-rot-in -131.86, -170.63 59.19, 79.74 193.14, 11.06 -107.54, 18.21 299.51, 108.05 -63.79, -34.15 in-in in 8.533 Saltbr-in 2.729 HRD-in -94.19, -44.57 77.57, -18.69 in-in-none SNCiin in-none ActLoopNT-in 3.395 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.64 APE8-dihe-in -69.1, 125.41 APE8-rot-na 27.89 APE67-dihe-in -65.46, -25.99 -62.37, -38.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.112 None None None XRAY 2.15 0.252 0.285 H 276 264 12 0 0 12 [[270, 521]] 1.0 6e6e TYR_SRC_HUMAN TYR 1.5e-94 322.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOA P12931 260 536 536.0 DB8:60601 Type1 None DFGin 6.485 14.992 BLAminus DFGAsp-rot-in -136.89, -177.13 60.13, 67.22 210.35, -70.32 -88.08, 17.88 299.37, 80.4 -39.41, -49.93 in-in in 8.209 Saltbr-in 3.007 HRD-in -88.6, -49.05 78.24, -0.79 in-in-none SNCiin in-none ActLoopNT-in 2.923 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.4 APE8-dihe-in -68.65, 109.43 APE8-rot-na 30.28 APE67-dihe-in -65.46, -35.11 -60.6, -22.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.961 None None None XRAY 2.105 0.212 0.254 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxo TYR_SRC_HUMAN TYR 1.7e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOB P12931 261 536 536.0 DB8:60601 Type1 None DFGin 6.117 14.771 BLAminus DFGAsp-rot-in -143.71, -172.1 53.51, 74.85 217.28, -77.55 -94.55, 12.21 299.33, 86.01 -48.26, -39.95 in-in in 7.978 Saltbr-in 3.027 HRD-in -94.91, -49.82 82.99, -7.9 in-in-none SNCiin in-none ActLoopNT-in 2.965 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.53 APE8-dihe-in -48.6, 109.34 APE8-rot-na 16.54 APE67-dihe-in -71.78, -28.01 -62.09, -30.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.732 None None None XRAY 2.105 0.212 0.254 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxo TYR_SRC_HUMAN TYR 1.7e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 6ATEA P12931 260 536 536.0 6H3:601 Type1 None DFGin 7.041 15.169 BLAminus DFGAsp-rot-in -135.65, -168.07 66.14, 79.15 191.72, 15.79 -116.32, 24.48 292.22, 93.52 -64.92, -24.87 in-in in 7.679 Saltbr-in 3.4 HRD-in -88.24, -48.16 78.13, -11.21 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 49.92 APE8-rot-na 24.35 APE67-dihe-in -67.09, -18.78 -61.23, -36.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.402 0.195 0.228 A 286 255 22 0 0 14 [[270, 521]] 1.0 6ate TYR_SRC_HUMAN TYR 1.7e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SYK KSYK_HUMAN 1XBBA P43405 363 635 635.0 STI:60001 Type1 None DFGin 6.664 14.623 BLAminus DFGAsp-rot-in -128.05, 176.75 68.38, 79.08 204.6, -30.64 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.236 Saltbr-in 3.032 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.126 APE9-dist-na 7.2 None None None XRAY 1.57 0.191 0.221 A 291 264 9 0 0 4 [[370, 628]] 1.0 1xbb TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3FQHB P43405 363 633 635.0 057:2 Type1 None DFGin 6.512 14.384 BLAminus DFGAsp-rot-in -135.61, -177.0 61.05, 83.05 203.68, -27.77 -100.81, 28.19 289.97, 93.91 -68.13, -27.21 in-in in 7.95 Saltbr-in 2.929 HRD-in -70.78, -57.98 73.35, 4.27 in-in-none SNCiin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 140.44 APE9-dihe-in -122.67, 149.45 APE8-dihe-in -71.04, 64.02 APE8-rot-na 27.55 APE67-dihe-in -70.95, -10.14 -42.56, -38.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.931 APE9-dist-na 7.058 None None None XRAY 2.26 0.216 0.259 B 291 258 13 0 0 4 [[370, 628]] 1.0 3fqh TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3FQSA P43405 363 635 635.0 585:60001 Type1 None DFGin 6.671 15.119 BLAminus DFGAsp-rot-in -130.1, -168.06 51.07, 81.04 201.27, -8.08 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.251 Saltbr-in 2.89 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.716 APE9-dist-na 7.49 None None None XRAY 2.1 0.218 0.253 A 291 264 9 0 0 4 [[370, 628]] 1.0 3fqs TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FYNA P43405 363 635 635.0 0VE:60701 Type1 None DFGin 6.322 14.552 BLAminus DFGAsp-rot-in -125.05, -173.65 56.58, 84.17 192.6, 0.66 -104.44, 22.0 295.83, 84.03 -64.28, -16.7 in-in in 8.168 Saltbr-in 2.747 HRD-in -77.65, -54.89 74.1, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 150.74 APE9-dihe-in -119.38, 130.75 APE8-dihe-in -71.21, 75.44 APE8-rot-na 25.91 APE67-dihe-in -62.88, -14.32 -62.84, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.751 APE9-dist-na 7.34 None None None XRAY 2.318 0.228 0.269 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyn TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FZ6A P43405 363 635 635.0 0VG:60701 Type1 None DFGin 6.317 14.691 BLAminus DFGAsp-rot-in -133.65, -169.74 58.51, 78.15 191.33, -6.29 -100.44, 26.78 291.45, 90.91 -64.04, -31.24 in-in in 8.443 Saltbr-in 3.006 HRD-in -75.46, -52.97 71.45, 4.73 in-in-none SNCiin in-none ActLoopNT-in 2.901 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 139.2 APE9-dihe-in -115.79, 143.14 APE8-dihe-in -76.09, 69.74 APE8-rot-na 28.85 APE67-dihe-in -66.47, -14.43 -53.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.466 APE9-dist-na 7.234 None None None XRAY 1.85 0.23 0.253 A 291 262 11 0 0 4 [[370, 628]] 1.0 4fz6 TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4I0RA P43405 363 635 635.0 1B4:60701 Type1 None DFGin 6.303 14.472 BLAminus DFGAsp-rot-in -120.7, -175.74 66.13, 76.03 192.36, -6.54 -99.52, 27.66 293.49, 90.9 -68.19, -27.87 in-in in 8.079 Saltbr-in 2.795 HRD-in -77.52, -55.13 72.71, 3.63 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 132.26 APE9-dihe-in -103.47, 139.74 APE8-dihe-in -70.94, 75.19 APE8-rot-na 28.76 APE67-dihe-in -61.34, -17.47 -59.11, -38.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.727 APE9-dist-na 7.158 None None None XRAY 2.1 0.237 0.272 A 291 260 13 0 0 4 [[370, 628]] 1.0 4i0r TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4I0SA P43405 363 635 635.0 1B5:60701 Type1 None DFGin 6.348 14.318 BLAminus DFGAsp-rot-in -129.27, -175.27 55.43, 83.6 204.86, -24.79 -98.08, 24.19 289.58, 86.12 -61.12, -27.32 in-in in 8.034 Saltbr-in 2.589 HRD-in -71.15, -52.29 70.43, 7.1 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 126.23 APE9-dihe-in -113.12, 145.51 APE8-dihe-in -74.21, 66.56 APE8-rot-na 27.25 APE67-dihe-in -64.4, -15.49 -48.66, -38.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.673 APE9-dist-na 7.239 None None None XRAY 1.98 0.218 0.236 A 291 263 10 0 0 4 [[370, 628]] 1.0 4i0s TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4I0TA P43405 363 635 635.0 1B6:60701 Type1 None DFGin 6.448 14.275 BLAminus DFGAsp-rot-in -133.28, -166.54 54.17, 83.04 203.23, -16.65 -99.17, 23.72 289.92, 92.88 -54.78, -30.8 in-in in 8.482 Saltbr-in 2.757 HRD-in -78.62, -52.01 75.91, 3.75 in-in-none SNCiin in-none ActLoopNT-in 3.005 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.47 APE8-dihe-in -63.58, 54.66 APE8-rot-na 27.19 APE67-dihe-in -65.32, -17.31 -39.09, -36.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.562 None None None XRAY 1.7 0.236 0.268 A 291 262 11 0 0 5 [[370, 628]] 1.0 4i0t TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5T68A P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.399 14.233 BLAminus DFGAsp-rot-in -118.2, -175.03 55.02, 90.22 214.09, -22.65 -105.11, 31.93 294.35, 102.52 -80.93, -22.27 in-in in 7.864 Saltbr-in 2.767 HRD-in -79.38, -47.76 69.54, -3.58 in-in-none SNCiin in-none ActLoopNT-in 3.07 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -53.8 APE9-dihe-in -121.95, 75.31 APE8-dihe-in -77.88, 51.45 APE8-rot-na 19.76 APE67-dihe-in -78.2, -26.54 -39.48, -21.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.291 APE9-dist-na 7.587 None None None XRAY 2.93 0.188 0.281 A 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5T68B P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.335 14.549 BLAminus DFGAsp-rot-in -125.81, -173.18 53.62, 72.36 200.55, -14.17 -90.46, 31.38 289.78, 97.36 -69.64, -47.12 in-in in 7.859 Saltbr-in 2.795 HRD-in -56.8, -40.48 64.3, -8.06 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -66.53 APE9-dihe-in -122.76, 73.0 APE8-dihe-in -76.02, 70.05 APE8-rot-na 29.83 APE67-dihe-in -58.48, -8.81 -36.73, -49.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.244 APE9-dist-na 6.86 None None None XRAY 2.93 0.188 0.281 B 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5Y5UB P43405 363 629 635.0 8OU:701 Type1 None DFGin 6.322 13.999 BLAminus DFGAsp-rot-in -136.83, 172.48 60.12, 69.06 200.21, -19.72 -76.3, 17.06 301.14, 79.7 -45.71, -46.86 in-in in 7.647 Saltbr-in 2.798 HRD-in -72.89, -51.34 74.65, -2.0 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.91 APE8-rot-na 27.44 APE67-dihe-in -59.42, -23.8 -55.69, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.14 0.239 0.26 B 293 257 10 0 0 6 [[370, 628]] 1.0 5y5u TYR_SYK_HUMAN TYR 5.8e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3VF8A P43405 363 635 635.0 0JE:701 Type1 None DFGin 6.303 14.274 BLAminus DFGAsp-rot-in -127.47, -170.59 55.16, 83.49 191.7, 10.26 -101.53, 21.98 288.96, 89.41 -58.75, -35.76 in-none in 8.043 Saltbr-none 999.0 HRD-in -73.27, -51.41 67.21, 6.99 none-in-in SNCnii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.14, 90.57 APE9-dihe-in -105.62, 138.03 APE8-dihe-in -81.27, 73.81 APE8-rot-na 26.23 APE67-dihe-in -66.47, -16.98 -51.38, -34.52 APE12-dist-na 13.257 APE11-dist-na 10.092 APE10-dist-na 10.007 APE9-dist-na 6.796 None None None XRAY 2.08 0.217 0.241 A 299 265 8 0 0 0 [[370, 628]] 1.0 3vf8 TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3VF9A P43405 364 635 635.0 477:701 Type1 None DFGin 6.396 14.64 BLAminus DFGAsp-rot-in -128.07, -174.94 57.37, 81.54 194.35, 12.97 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.207 APE11-dist-na 10.508 APE10-dist-na 9.877 APE9-dist-na 6.696 None None None XRAY 2.3 0.255 0.267 A 299 265 7 0 0 0 [[370, 628]] 1.0 3vf9 TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6ZCRA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus DFGAsp-rot-in -131.25, -174.99 58.52, 82.29 194.43, -8.77 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcr TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6ZCUA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus DFGAsp-rot-in -131.25, -174.99 58.52, 82.29 194.43, -8.77 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcu TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR TNK2 ACK1_HUMAN 1U4DA Q07912 117 389 1038.0 DBQ:398 Type1 None DFGin 6.5 13.536 BLAminus DFGAsp-rot-in -127.17, -169.67 54.12, 72.77 205.32, -17.94 -87.16, 24.56 310.51, 109.17 -62.52, -20.25 in-in in 8.735 Saltbr-in 3.176 HRD-in -80.08, -48.95 65.72, 7.9 in-in-none SNCiin in-none ActLoopNT-in 3.172 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -41.24 APE8-dihe-in -76.48, 82.61 APE8-rot-na 31.13 APE67-dihe-in -69.93, -17.0 -48.99, -48.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.562 None None None XRAY 2.1 0.205 0.248 A 291 258 15 0 0 7 [[126, 387]] 1.0 1u4d TYR_TNK2_HUMAN TYR 9.3e-86 293.3 1 259 259 269 270 271 273 275 158 177 181 249 251 250 252 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TYK2-2 TYK2_HUMAN 7UYSA P29597 890 1177 1187.0 OVC:1201 Type1 None DFGin 6.822 13.649 BLAminus DFGAsp-rot-in -114.45, -171.35 44.56, 84.78 206.53, -7.12 -101.1, 35.58 297.8, 80.57 -68.2, -34.51 in-in in 8.175 Saltbr-in 2.706 HRD-in -81.8, -57.11 76.46, 1.75 in-in-none SNCiin in-none ActLoopNT-in 2.909 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -43.18 APE9-dihe-in -68.5, 119.8 APE8-dihe-in -75.42, 76.63 APE8-rot-na 32.55 APE67-dihe-in -73.48, -8.09 -58.48, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.841 APE9-dist-na 6.505 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.15 0.232 0.272 A 289 282 6 0 0 4 [[589, 868], [897, 1171]] 2.0 7uys TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 7UYUA P29597 889 1177 1187.0 OV0:1201 Type1 None DFGin 6.732 13.693 BLAminus DFGAsp-rot-in -116.0, -173.86 46.69, 88.81 204.6, -11.04 -102.3, 31.38 294.59, 76.31 -71.39, -32.91 in-in in 7.837 Saltbr-in 3.038 HRD-in -86.52, -53.34 77.94, 2.86 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.29 APE8-dihe-in -82.32, 79.72 APE8-rot-na 31.91 APE67-dihe-in -72.66, -7.56 -62.66, -28.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.58 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.05 0.227 0.257 A 289 269 20 0 0 7 [[589, 868], [897, 1171]] 2.0 7uyu TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 6AAMA P29597 888 1178 1187.0 9T6:1201 Type1 None DFGin 6.808 13.614 BLAminus DFGAsp-rot-in -114.96, -166.83 46.97, 77.56 198.31, -12.49 -91.7, 20.81 290.41, 78.57 -55.84, -27.39 in-in in 7.95 Saltbr-in 2.732 HRD-in -93.28, -50.85 70.68, 8.06 in-in-none SNCiin in-none ActLoopNT-in 2.803 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 25.87 APE8-rot-na 15.0 APE67-dihe-in -73.41, -4.27 -60.18, -33.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A None None XRAY 1.98 0.204 0.238 A 298 269 22 0 0 14 [[589, 868], [897, 1171]] 2.0 6aam TYR_TYK2-2_HUMAN TYR 3.5e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Activity: None (unassigned)

Total number of chains: 412
Active chains: 0
Total number of genes: 76
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 412 100.0% 5NTJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL FERONIA FERON_ARATH 9UBIB Q9SCZ4 521 816 895.0 OT5:901 Type1 None DFGin 6.782 15.892 BLAminus DFGAsp-rot-in -126.95, 177.64 72.17, 75.0 196.1, 6.81 -97.07, 12.88 279.92, 75.65 -57.81, -31.55 in-in in 8.98 Saltbr-in 2.654 HRD-in -66.15, -44.35 78.97, -8.69 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.59 APE8-dihe-in -127.69, 126.66 APE8-rot-in 307.15 APE67-dihe-inflip 94.57, -22.8 -51.35, 136.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.69 None None None XRAY 1.9 0.172 0.203 B 327 282 14 0 0 14 [[535, 809]] 1.0 9ubi Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2.4e-57 200.5 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA A0A6H0TJ16 1 862 872.0 ATP:60902 ATPlike None DFGin 6.64 14.881 BLAminus DFGAsp-rot-in -119.81, 176.45 65.16, 86.81 194.33, 0.5 -107.13, 32.95 280.75, 71.48 -74.73, -19.84 in-in in 7.41 Saltbr-in 2.775 HRD-na-- -76.54, -26.64 101.12, -25.28 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 A 904 845 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.5e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAOD A0A6H0TJ16 4 862 872.0 No_ligand No_ligand None DFGin 6.279 14.693 BLAminus DFGAsp-rot-in -127.01, -175.75 60.9, 110.51 197.96, -17.24 -134.43, 28.25 273.89, 91.9 -76.89, -10.35 in-in in 7.91 Saltbr-in 2.986 HRD-na-- -74.11, -15.09 88.71, -29.49 in-in-none SNCiin in-none ActLoopNT-in 2.822 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.502 0.249 0.307 D 859 845 0 0 0 0 [[228, 410]] 1.0 8sao Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.4 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
AGC PRKACA KAPCA_BOVIN 9DW8G P00517 15 329 351.0 ANP:403 ATPlike None DFGin 6.07 14.235 BLAminus DFGAsp-rot-in -131.43, -174.72 59.27, 66.66 212.77, -31.96 -86.28, 33.46 293.19, 93.28 -61.23, -49.05 in-none in 9.911 Saltbr-none 999.0 HRD-in -98.32, -49.71 57.42, 11.15 none-in-in SNCnii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.06, 160.73 APE9-dihe-na 123.3, -175.7 APE8-dihe-in -89.52, 132.72 APE8-rot-in 298.44 APE67-dihe-in -69.93, -27.98 -56.75, -38.6 APE12-dist-in 8.7 APE11-dist-in 11.593 APE10-dist-in 6.411 APE9-dist-in 4.803 None TPO198 TPO198 EM 3.5 999.0 999.0 G 351 309 0 0 0 0 [[44, 298]] 1.0 9dw8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EH2A P25321 1 351 351.0 AMP:60401 ATPlike None DFGin 6.764 14.919 BLAminus DFGAsp-rot-in -126.18, 164.33 76.56, 92.11 196.17, -17.64 -105.87, 26.81 282.23, 79.7 -66.18, -22.24 in-none in 9.226 Saltbr-none 999.0 HRD-in -87.75, -53.65 70.54, 10.24 none-in-in SNCnii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.34, 158.08 APE9-dihe-na 131.59, -168.87 APE8-dihe-in -114.41, 135.93 APE8-rot-in 298.36 APE67-dihe-in -58.8, -22.41 -48.5, -50.6 APE12-dist-in 8.204 APE11-dist-in 11.426 APE10-dist-in 5.845 APE9-dist-in 3.719 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.76 0.177 0.21 A 353 343 3 0 0 0 [[44, 298]] 1.0 6eh2 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5NTJA P25321 1 351 351.0 No_ligand No_ligand None DFGin 6.758 15.589 BLAminus DFGAsp-rot-in -126.6, 164.17 70.8, 88.44 204.78, -18.34 -97.34, 22.68 279.05, 78.65 -62.01, -27.43 in-none in 9.318 Saltbr-none 999.0 HRD-in -87.71, -52.99 72.74, 12.02 none-in-in SNCnii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.35, 157.73 APE9-dihe-na 127.06, -161.94 APE8-dihe-in -121.61, 135.07 APE8-rot-in 297.67 APE67-dihe-in -60.56, -23.81 -48.81, -50.06 APE12-dist-in 8.184 APE11-dist-in 11.508 APE10-dist-in 5.834 APE9-dist-in 3.661 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.56 0.142 0.177 A 353 348 0 0 0 0 [[44, 298]] 1.0 5ntj Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERUA P25321 1 351 351.0 No_ligand No_ligand None DFGin 6.708 15.352 BLAminus DFGAsp-rot-in -122.01, 161.76 78.09, 83.83 205.12, -24.69 -91.35, 27.07 283.0, 77.27 -61.22, -29.16 in-none in 9.324 Saltbr-none 999.0 HRD-in -85.44, -56.28 74.88, 7.63 none-in-in SNCnii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.17, 161.42 APE9-dihe-na 121.37, -170.91 APE8-dihe-in -112.44, 135.97 APE8-rot-in 301.67 APE67-dihe-in -61.32, -23.67 -50.09, -48.07 APE12-dist-in 8.242 APE11-dist-in 11.514 APE10-dist-in 5.856 APE9-dist-in 3.626 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.15 0.207 0.245 A 353 348 1 0 0 0 [[44, 298]] 1.0 6eru Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERVA P25321 1 351 351.0 No_ligand No_ligand None DFGin 6.715 15.392 BLAminus DFGAsp-rot-in -125.08, 156.65 78.53, 86.88 200.46, -21.71 -92.73, 25.79 280.28, 78.54 -65.37, -20.87 in-none in 9.234 Saltbr-none 999.0 HRD-in -86.89, -53.48 76.44, 7.72 none-in-in SNCnii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.6, 158.99 APE9-dihe-na 121.28, -168.45 APE8-dihe-in -116.16, 134.01 APE8-rot-in 298.45 APE67-dihe-in -57.32, -26.83 -47.6, -49.92 APE12-dist-in 8.235 APE11-dist-in 11.488 APE10-dist-in 5.94 APE9-dist-in 3.644 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.06 0.181 0.217 A 353 341 0 0 0 0 [[44, 298]] 1.0 6erv Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y2OA P25321 1 351 351.0 O72:60406 Type1 None DFGin 6.423 14.135 BLAminus DFGAsp-rot-in -118.81, 164.94 68.54, 89.57 196.17, -4.16 -98.17, 23.6 280.79, 62.09 -51.58, -34.71 in-none in 8.664 Saltbr-none 999.0 HRD-in -99.33, -52.87 71.55, 6.25 none-in-in SNCnii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.56, 161.43 APE9-dihe-na 131.48, -155.68 APE8-dihe-in -122.0, 132.63 APE8-rot-in 297.96 APE67-dihe-in -62.6, -21.6 -48.71, -46.53 APE12-dist-in 8.147 APE11-dist-in 11.473 APE10-dist-in 5.973 APE9-dist-in 3.649 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.01 0.223 0.254 A 353 351 0 0 0 0 [[44, 298]] 1.0 6y2o Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 2OIQB P00523 258 533 533.0 No_ligand No_ligand None DFGin 6.913 15.576 BLAminus DFGAsp-rot-in -142.56, -175.83 61.81, 70.38 187.08, -62.72 -92.15, 20.71 278.09, 99.28 -54.55, -32.91 in-in in 8.301 Saltbr-in 3.439 HRD-in -88.35, -51.81 77.34, -5.91 in-in-none SNCiin in-none ActLoopNT-in 2.902 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.21 APE8-dihe-in -58.92, 99.35 APE8-rot-na 30.44 APE67-dihe-in -64.06, -24.16 -53.88, -29.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.765 None None None XRAY 2.07 0.232 0.263 B 286 265 11 0 0 11 [[267, 518]] 1.0 2oiq Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EL8B P00523 256 533 533.0 No_ligand No_ligand None DFGin 6.812 15.286 BLAminus DFGAsp-rot-in -135.13, -174.74 50.6, 76.63 195.75, 3.16 -94.45, 27.76 283.26, 100.84 -52.25, -33.62 in-in in 8.385 Saltbr-in 2.842 HRD-in -86.68, -50.91 78.07, -6.49 in-in-none SNCiin in-none ActLoopNT-in 2.809 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.84 APE8-dihe-in -59.36, 97.16 APE8-rot-na 33.19 APE67-dihe-in -70.48, -20.47 -51.02, -25.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.719 None None None XRAY 2.3 0.218 0.262 B 286 259 19 0 0 13 [[267, 518]] 1.0 3el8 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 6HVEA P00523 256 533 533.0 GUW:601 Type1 None DFGin 6.556 13.854 BLAminus DFGAsp-rot-in -130.43, -171.9 51.09, 81.04 202.44, -29.7 -93.96, 22.87 297.19, 88.85 -57.14, -30.42 in-in in 7.625 Saltbr-in 2.575 HRD-in -94.1, -50.52 77.55, 0.96 in-in-none SNCiin in-none ActLoopNT-in 2.966 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.61 APE8-dihe-in -71.31, 110.91 APE8-rot-na 28.27 APE67-dihe-in -67.95, -34.2 -60.25, -23.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.096 T338M,S345C None None XRAY 1.9 0.178 0.203 A 286 267 11 0 0 11 [[267, 518]] 1.0 6hve Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XA P00523 255 533 533.0 IHH:1 Type1 None DFGin 6.455 14.068 BLAminus DFGAsp-rot-in -145.58, -171.22 50.93, 84.46 185.15, -60.61 -103.71, 27.02 296.31, 84.62 -56.44, -32.19 in-in in 7.775 Saltbr-in 2.792 HRD-in -87.12, -53.49 80.13, -9.7 in-in-none SNCiin in-none ActLoopNT-in 2.947 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 137.19 APE9-dihe-in -75.66, 152.05 APE8-dihe-in -49.31, 94.84 APE8-rot-na 28.47 APE67-dihe-in -60.1, -19.69 -50.76, -42.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.676 APE9-dist-na 6.248 None None None XRAY 2.35 0.234 0.266 A 286 264 15 0 0 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XD P00523 257 533 533.0 IHH:1 Type1 None DFGin 6.391 14.772 BLAminus DFGAsp-rot-in -139.04, 173.47 61.43, 85.17 192.55, -14.26 -101.0, 30.99 295.99, 108.16 -61.08, -19.89 in-in in 8.602 Saltbr-in 2.872 HRD-in -82.85, -51.65 79.89, -0.15 in-in-none SNCiin in-none ActLoopNT-in 2.966 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 70.66 APE9-dihe-in -69.9, 165.23 APE8-dihe-in -59.79, 102.15 APE8-rot-na 28.02 APE67-dihe-in -64.62, -18.4 -51.92, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.772 APE9-dist-na 6.301 None None None XRAY 2.35 0.234 0.266 D 286 267 10 0 0 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4O2PB P00523 256 533 533.0 11V:601 Type1 None DFGin 6.534 14.364 BLAminus DFGAsp-rot-in -130.18, -167.75 45.02, 75.41 198.01, -19.41 -89.8, 19.65 297.38, 91.22 -55.38, -19.97 in-in in 8.19 Saltbr-in 3.223 HRD-in -85.06, -50.51 80.17, -8.96 in-in-none SNCiin in-none ActLoopNT-in 2.9 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.91 APE8-dihe-in -66.46, 102.48 APE8-rot-na 28.3 APE67-dihe-in -66.72, -24.63 -58.29, -29.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.712 None None None XRAY 2.1 0.197 0.238 B 286 265 13 0 0 12 [[267, 518]] 1.0 4o2p Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5XP7B P00523 256 533 533.0 8C6:601 Type1 None DFGin 6.645 14.268 BLAminus DFGAsp-rot-in -134.44, -176.16 50.89, 76.48 191.19, 5.98 -90.12, 24.26 289.46, 88.6 -62.66, -19.97 in-in in 8.286 Saltbr-in 3.224 HRD-in -90.41, -49.69 74.77, 0.35 in-in-none SNCiin in-none ActLoopNT-in 2.978 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.58 APE8-dihe-in -67.72, 110.71 APE8-rot-na 25.27 APE67-dihe-in -70.91, -25.72 -56.94, -25.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.069 None None None XRAY 2.012 0.169 0.198 B 286 267 11 0 0 11 [[267, 518]] 1.0 5xp7 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4MCVA P00523 256 533 533.0 29K:601 Type1 None DFGin 6.255 14.18 BLAminus DFGAsp-rot-in -139.77, -175.96 57.49, 90.62 189.12, -88.18 -111.94, 64.22 308.36, 94.27 -85.67, 117.17 in-in in 7.676 Saltbr-in 3.59 HRD-in -94.67, -38.67 68.11, -0.39 in-in-none SNCiin in-none ActLoopNT-in 3.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 102.41 APE8-dihe-in -74.67, 65.8 APE8-rot-na 28.47 APE67-dihe-in -64.37, -31.73 -64.06, -34.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.578 T338G None None XRAY 2.73 0.243 0.29 A 278 267 11 0 0 11 [[267, 518]] 1.0 4mcv Gallus gallus TYR_SRC_CHICK TYR 2.6e-93 318.0 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3G5DA P00523 257 533 533.0 1N1:1 Type1.5_Back None DFGin 6.719 14.175 BLAminus DFGAsp-rot-in -122.29, -173.62 52.53, 77.9 199.96, -25.62 -96.14, 20.03 300.27, 89.98 -55.15, -32.52 in-in in 8.226 Saltbr-in 3.471 HRD-in -89.79, -51.87 81.03, -11.33 in-in-none SNCiin in-none ActLoopNT-in 3.185 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.62 APE8-dihe-in -62.24, 114.12 APE8-rot-na 23.22 APE67-dihe-in -69.68, -25.09 -60.39, -25.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.756 S345C None None XRAY 2.2 0.207 0.257 A 286 256 21 0 0 13 [[267, 518]] 1.0 3g5d Gallus gallus TYR_SRC_CHICK TYR 4.6e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.602 14.979 BLAminus DFGAsp-rot-in -141.71, -172.51 72.43, 72.08 198.45, 9.85 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.146 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.357 APE11-dist-in 10.489 APE10-dist-in 5.018 APE9-dist-in 3.48 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311 284 0 0 0 0 [[82, 342]] 1.0 4ct1 Homo sapiens AGC_PDPK1_HUMAN AGC 9.8e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD0A O15530 73 358 556.0 3Q4:370 Type1.5_Front None DFGin 6.584 14.791 BLAminus DFGAsp-rot-in -135.89, -173.14 73.55, 73.02 182.88, 14.17 -106.35, 12.12 281.49, 88.39 -54.84, -35.9 in-in in 8.526 Saltbr-in 2.573 HRD-in -72.98, -50.98 74.13, -9.69 in-in-none SNCiin in-none ActLoopNT-in 2.851 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.13 APE8-dihe-in -74.4, 123.75 APE8-rot-in 309.46 APE67-dihe-in -59.36, -28.41 -43.01, -50.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.765 None SEP241 SEP241 XRAY 1.99 0.191 0.231 A 312 274 12 0 0 12 [[82, 342]] 1.0 3qd0 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3QD4A O15530 71 358 556.0 3Q6:360 Type1.5_Front None DFGin 6.403 14.626 BLAminus DFGAsp-rot-in -137.72, -173.39 72.99, 75.84 178.14, 13.4 -110.69, 10.4 285.12, 91.81 -64.41, -29.28 in-in in 8.558 Saltbr-in 2.79 HRD-in -69.09, -51.69 76.33, -7.4 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.49 APE8-dihe-in -83.46, 122.24 APE8-rot-in 298.92 APE67-dihe-in -62.96, -22.94 -34.73, -56.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.12 None SEP241 SEP241 XRAY 2.3 0.199 0.244 A 312 276 12 0 0 12 [[82, 342]] 1.0 3qd4 Homo sapiens AGC_PDPK1_HUMAN AGC 1.3e-84 289.3 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2 12.865 BLAminus DFGAsp-rot-in -142.99, -166.55 58.77, 70.37 191.3, 11.27 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.166 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.152 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.603 APE11-dist-in 12.253 APE10-dist-in 6.595 APE9-dist-in 3.928 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596 322 9 0 0 0 [[254, 522]] 1.0 9ejm Homo sapiens AGC_PRKCI_HUMAN AGC 5.3e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZC P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.35 12.565 BLAminus DFGAsp-rot-in -139.32, -164.03 47.55, 59.28 216.71, 4.72 -80.83, 61.9 308.74, 123.06 -106.89, -43.16 in-none in 9.109 Saltbr-none 999.0 HRD-in -73.5, -52.72 54.13, -0.86 none-in-in SNCnii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -173.36, 149.93 APE9-dihe-na 148.31, -160.27 APE8-dihe-in -114.43, 136.89 APE8-rot-in 309.46 APE67-dihe-in -57.11, -55.6 -58.53, -45.22 APE12-dist-in 9.055 APE11-dist-in 10.952 APE10-dist-in 5.478 APE9-dist-in 4.001 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 C 345 317 15 0 0 0 [[254, 522]] 1.0 6ilz Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZE P41743 255 587 596.0 AFU:601 Type1 None DFGin 6.957 12.846 BLAminus DFGAsp-rot-in -133.5, 178.86 66.81, 59.27 191.09, -13.89 -86.16, 63.15 305.7, 112.11 -113.68, -42.34 in-none in 8.722 Saltbr-none 999.0 HRD-in -57.41, -56.51 65.78, 5.3 none-in-in SNCnii in-in ActLoopNT-in 3.206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.18, 118.96 APE9-dihe-na -158.88, 157.43 APE8-dihe-in -112.73, 131.93 APE8-rot-in 318.3 APE67-dihe-in -62.09, -40.72 -61.87, -47.3 APE12-dist-in 9.305 APE11-dist-in 10.843 APE10-dist-in 5.436 APE9-dist-in 4.947 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 E 345 316 16 0 0 0 [[254, 522]] 1.0 6ilz Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 6ILZG P41743 254 587 596.0 AFU:601 Type1 None DFGin 6.208 12.257 BLAminus DFGAsp-rot-in -148.76, -174.16 47.03, 68.4 201.65, 19.07 -82.07, 61.51 312.36, 107.63 -107.63, -40.38 in-none in 8.922 Saltbr-none 999.0 HRD-in -68.38, -50.26 58.54, -1.28 none-in-in SNCnii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.9, 131.51 APE9-dihe-na -176.4, 176.09 APE8-dihe-in -116.21, 141.66 APE8-rot-in 312.23 APE67-dihe-in -65.11, -53.96 -57.73, -45.37 APE12-dist-in 8.827 APE11-dist-in 10.598 APE10-dist-in 4.936 APE9-dist-in 4.581 None TPO412,TPO564 TPO412,TPO564 XRAY 3.261 0.31 0.348 G 345 315 14 0 0 0 [[254, 522]] 1.0 6ilz Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 6BDLB Q13976 337 671 671.0 No_ligand No_ligand None DFGin 5.757 14.658 BLAminus DFGAsp-rot-in -124.78, 164.72 65.46, 95.48 191.95, 8.91 -109.07, 28.23 278.78, 64.61 -59.31, -33.14 in-in in 9.337 Saltbr-in 2.902 HRD-in -92.19, -47.19 78.26, -40.54 in-in-none SNCiin in-none ActLoopNT-in 2.877 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -122.13, 167.41 APE9-dihe-na 91.21, 161.43 APE8-dihe-in -67.63, 145.68 APE8-rot-none 999.0 APE67-dihe-in -70.27, -17.78 -60.28, -30.02 APE12-dist-in 7.598 APE11-dist-in 11.396 APE10-dist-in 5.795 APE9-dist-in 5.468 None TPO517 TPO517 XRAY 1.96 0.209 0.222 B 347 335 0 0 0 0 [[360, 619]] 1.0 6bdl Homo sapiens AGC_PRKG1_HUMAN AGC 2.7e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S26B Q13464 6 402 1354.0 86K:60502 Type1 None DFGin 5.894 13.466 BLAminus DFGAsp-rot-in -142.81, 170.64 62.27, 84.33 180.92, 6.5 -99.22, -25.13 305.67, 98.88 -149.72, 999.0 in-in in 8.694 Saltbr-in 2.732 HRD-in -65.9, -38.81 79.64, -62.78 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.9, -32.72 999.0, -32.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.744 0.247 0.269 B 398 372 19 0 0 19 [[76, 338]] 1.0 7s26 Homo sapiens AGC_ROCK1_HUMAN AGC 3.2e-94 320.9 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 5WNEB Q13464 6 402 1354.0 B4J:60900 Type1.5_Front None DFGin 6.158 13.429 BLAminus DFGAsp-rot-in -143.39, 177.51 52.52, 73.92 190.34, 63.29 -94.42, 17.67 303.21, 98.37 -69.6, 5.07 in-in in 8.386 Saltbr-in 2.849 HRD-in -60.97, -51.26 69.54, -7.09 in-in-none SNCiin in-none ActLoopNT-in 3.235 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -78.48, -24.9 999.0, -22.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.229 0.246 B 415 351 34 0 0 9 [[76, 338]] 1.0 5wne Homo sapiens AGC_ROCK1_HUMAN AGC 3.6e-94 320.7 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 7JOVB O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.272 13.248 BLAminus DFGAsp-rot-in -142.1, 173.55 61.9, 71.69 203.02, 2.17 -93.43, 17.34 301.23, 105.57 -59.73, -16.68 in-in in 8.529 Saltbr-in 2.63 HRD-in -62.93, -47.02 69.4, -4.67 in-in-none SNCiin in-none ActLoopNT-in 3.098 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -66.0, -25.51 999.0, -48.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 B 395 378 11 0 0 8 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVD O75116 25 417 1388.0 VFS:501 Type1 None DFGin 6.243 13.357 BLAminus DFGAsp-rot-in -142.23, 173.1 61.78, 71.13 202.33, 1.42 -91.99, 20.3 301.3, 105.37 -69.47, 5.8 in-in in 8.671 Saltbr-in 2.701 HRD-in -54.87, -50.75 69.64, -5.46 in-in-none SNCiin in-none ActLoopNT-in 3.181 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -32.28 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 D 395 361 26 0 0 15 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JOVE O75116 23 417 1388.0 VFS:501 Type1 None DFGin 6.298 13.257 BLAminus DFGAsp-rot-in -140.47, 172.73 62.89, 72.53 202.72, 4.17 -94.4, 16.26 301.6, 106.26 -62.28, -16.19 in-in in 8.454 Saltbr-in 2.74 HRD-in -64.4, -46.2 69.9, -8.61 in-in-none SNCiin in-none ActLoopNT-in 3.126 ActLoopCT-none nonTYR APEdihe_aanii APEdist_innn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 132.7 APE8-rot-in 314.77 APE67-dihe-in -47.56, -31.02 -61.45, -35.46 APE12-dist-in 8.281 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.586 0.185 0.217 E 395 385 4 0 0 3 [[92, 354]] 1.0 7jov Homo sapiens AGC_ROCK2_HUMAN AGC 2.3e-93 318.1 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTB O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.165 13.121 BLAminus DFGAsp-rot-in -141.64, 172.76 58.92, 82.45 190.78, 5.59 -101.4, 24.85 302.94, 103.08 -64.88, -17.44 in-in in 8.698 Saltbr-in 2.739 HRD-in -62.47, -54.27 74.29, -0.05 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.99, -27.47 999.0, -54.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 B 399 376 13 0 0 8 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTD O75116 25 417 1388.0 VFA:501 Type1 None DFGin 6.159 13.16 BLAminus DFGAsp-rot-in -143.53, 169.89 61.25, 83.67 196.73, -7.36 -103.29, 25.02 302.97, 101.79 -66.66, -17.12 in-in in 8.73 Saltbr-in 2.74 HRD-in -61.61, -54.54 74.16, -0.65 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.7 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 D 399 360 27 0 0 15 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7JNTE O75116 23 417 1388.0 VFA:501 Type1 None DFGin 6.214 13.058 BLAminus DFGAsp-rot-in -142.23, 169.06 60.85, 86.77 193.22, -6.74 -104.6, 25.19 302.23, 103.83 -66.31, -19.22 in-in in 8.573 Saltbr-in 2.668 HRD-in -56.89, -52.9 74.38, -3.32 in-in-none SNCiin in-none ActLoopNT-in 3.044 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 73.83 APE8-rot-in 306.93 APE67-dihe-in -51.63, -28.56 -78.96, -16.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.214 0.211 0.249 E 399 384 5 0 0 4 [[92, 354]] 1.0 7jnt Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NC O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.934 12.92 BLAminus DFGAsp-rot-in -146.55, 173.64 55.03, 95.19 187.78, -1.64 -112.85, 21.67 306.28, 93.38 -46.66, -30.29 in-in in 8.672 Saltbr-in 2.845 HRD-in -68.54, -48.47 75.35, -77.76 in-in-none SNCiin in-none ActLoopNT-in 3.188 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -54.16, -41.45 999.0, -46.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 C 399 378 12 0 0 6 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NE O75116 23 417 1388.0 5YS:501 Type1 None DFGin 5.955 12.867 BLAminus DFGAsp-rot-in -145.98, 174.14 54.43, 95.4 188.02, -2.13 -112.52, 20.29 306.04, 93.17 -47.1, -30.89 in-in in 8.6 Saltbr-in 2.849 HRD-in -68.77, -48.13 75.51, -77.25 in-in-none SNCiin in-none ActLoopNT-in 3.194 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.16, -41.37 999.0, -45.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 E 399 385 6 0 0 6 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6NH O75116 25 417 1388.0 5YS:501 Type1 None DFGin 5.924 12.987 BLAminus DFGAsp-rot-in -147.12, 173.74 54.77, 95.23 188.53, -1.37 -112.35, 21.15 305.58, 93.62 -44.02, -31.78 in-in in 8.754 Saltbr-in 2.84 HRD-in -68.48, -48.35 74.56, -77.19 in-in-none SNCiin in-none ActLoopNT-in 3.194 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.65, -39.86 999.0, -45.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.186 0.288 H 399 366 23 0 0 15 [[92, 354]] 1.0 7p6n Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OC O75116 22 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.02 13.098 BLAminus DFGAsp-rot-in -129.77, 174.02 63.85, 83.94 193.25, 3.03 -107.22, 35.66 304.43, 101.43 -71.69, -46.2 in-in in 8.669 Saltbr-in 2.758 HRD-in -67.24, -41.54 67.86, 2.47 in-in-none SNCiin in-none ActLoopNT-in 3.222 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.0, -37.44 999.0, -18.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 C 399 377 13 0 0 7 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 7P6OH O75116 24 417 1388.0 5YK:501 Type1.5_Front None DFGin 6.031 13.142 BLAminus DFGAsp-rot-in -130.18, 173.86 63.9, 84.23 193.08, 2.31 -107.39, 35.65 304.66, 101.19 -71.86, -45.96 in-in in 8.685 Saltbr-in 2.757 HRD-in -67.2, -41.51 67.93, 2.34 in-in-none SNCiin in-none ActLoopNT-in 3.218 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.17, -36.5 999.0, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.241 0.286 H 399 369 19 0 0 14 [[92, 354]] 1.0 7p6o Homo sapiens AGC_ROCK2_HUMAN AGC 2.4e-93 318.0 1 260 260 231 232 233 235 237 121 140 144 211 213 212 214 276 260 255 254 253 252 251 250 249 170 Rho-associated protein kinase 2
CAMK CAMK1 KCC1A_HUMAN 4FG7A Q14012 9 277 370.0 ATP:301 ATPlike None DFGin 6.733 14.558 BLAminus DFGAsp-rot-in -139.66, 179.97 56.25, 83.23 190.46, 14.91 -95.06, 23.76 286.93, 75.78 -57.64, -10.34 in-in in 9.756 Saltbr-in 2.988 HRD-in -66.62, -51.56 76.61, -3.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.43 APE8-dihe-in -71.0, 118.39 APE8-rot-in 317.82 APE67-dihe-inflip 114.74, -42.57 -57.89, 141.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.149 None None None XRAY 2.7 0.221 0.246 A 293 250 19 0 0 8 [[20, 276]] 1.0 4fg7 Homo sapiens CAMK_CAMK1_HUMAN CAMK 6.9e-97 329.7 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK2B KCC2B_HUMAN 3BHHC Q13554 11 300 666.0 No_ligand No_ligand None DFGin 6.71 15.561 BLAminus DFGAsp-rot-in -127.39, 170.7 56.71, 87.91 197.17, -0.16 -95.68, 30.86 287.9, 73.89 -64.42, -32.77 in-none in 9.882 Saltbr-none 999.0 HRD-in -64.65, -47.9 68.02, -0.98 none-in-in SNCnii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.86, 139.41 APE9-dihe-na 123.37, 177.52 APE8-dihe-in -97.47, 130.93 APE8-rot-in 302.95 APE67-dihe-in -58.71, -19.0 -38.4, -58.17 APE12-dist-in 10.568 APE11-dist-in 10.982 APE10-dist-in 5.56 APE9-dist-in 3.711 None None None XRAY 2.4 0.225 0.275 C 295 284 6 0 0 0 [[14, 272]] 1.0 3bhh Homo sapiens CAMK_CAMK2B_HUMAN CAMK 5.8e-96 326.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMK2B KCC2B_HUMAN 3BHHD Q13554 11 301 666.0 No_ligand No_ligand None DFGin 6.802 15.453 BLAminus DFGAsp-rot-in -126.24, 168.25 59.1, 86.86 200.92, -5.41 -95.28, 32.57 287.44, 73.92 -63.1, -40.24 in-none in 9.844 Saltbr-none 999.0 HRD-in -65.87, -48.06 64.84, 3.78 none-in-in SNCnii in-in ActLoopNT-in 2.879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.3, 137.4 APE9-dihe-na 124.14, 176.51 APE8-dihe-in -95.73, 129.7 APE8-rot-in 303.56 APE67-dihe-in -55.16, -23.5 -37.91, -59.42 APE12-dist-in 10.424 APE11-dist-in 11.055 APE10-dist-in 5.636 APE9-dist-in 3.692 None None None XRAY 2.4 0.225 0.275 D 295 285 6 0 0 0 [[14, 272]] 1.0 3bhh Homo sapiens CAMK_CAMK2B_HUMAN CAMK 5.8e-96 326.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMK2B KCC2B_HUMAN 3BHHA Q13554 11 301 666.0 5CP:60600 Type1 None DFGin 6.941 14.261 BLAminus DFGAsp-rot-in -119.83, 171.12 57.42, 88.31 200.23, 0.16 -100.0, 29.89 288.66, 72.13 -58.77, -42.96 in-none in 8.614 Saltbr-none 999.0 HRD-in -62.89, -50.32 68.63, 3.81 none-in-in SNCnii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -169.08, 140.79 APE9-dihe-na 120.18, 176.33 APE8-dihe-in -99.01, 129.74 APE8-rot-in 301.95 APE67-dihe-in -59.35, -19.21 -38.64, -57.08 APE12-dist-in 10.452 APE11-dist-in 11.057 APE10-dist-in 5.631 APE9-dist-in 3.668 None None None XRAY 2.4 0.225 0.275 A 295 287 4 0 0 0 [[14, 272]] 1.0 3bhh Homo sapiens CAMK_CAMK2B_HUMAN CAMK 5.8e-96 326.8 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II subunit beta
CAMK CAMKK2 KKCC2_HUMAN 6BRCA Q96RR4 161 448 588.0 E5J:60501 Type1 None DFGin 6.926 15.179 BLAminus DFGAsp-rot-in -120.53, 171.08 63.24, 80.67 194.7, -7.93 -89.54, 24.54 291.35, 76.67 -66.53, -18.07 in-none in 9.862 Saltbr-none 999.0 HRD-in -61.64, -52.23 71.81, 8.67 none-in-in SNCnii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.08, 165.18 APE9-dihe-na 110.63, -166.81 APE8-dihe-in -91.91, 115.92 APE8-rot-in 307.72 APE67-dihe-in -63.99, -23.41 -49.22, -36.7 APE12-dist-in 9.729 APE11-dist-in 11.45 APE10-dist-in 5.523 APE9-dist-in 3.785 None None None XRAY 2.2 0.216 0.265 A 291 263 25 0 0 0 [[165, 446]] 1.0 6brc Homo sapiens CAMK_CAMKK2_HUMAN CAMK 1.2e-73 253.6 1 256 256 329 330 331 333 335 194 236 240 309 311 310 312 372 357 352 351 350 349 348 347 346 268 Calcium/calmodulin-dependent protein kinase kinase 2
CAMK DAPK1 DAPK1_HUMAN 3ZXTB P53355 7 276 1430.0 ACP:1279 ATPlike None DFGin 6.575 14.067 BLAminus DFGAsp-rot-in -121.46, -170.78 56.12, 80.76 194.67, -0.01 -103.93, 17.27 282.46, 79.2 -56.39, -19.56 in-in in 8.68 Saltbr-in 2.544 HRD-in -82.72, -41.2 65.14, 3.07 in-in-none SNCiin in-none ActLoopNT-in 2.949 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -71.62 APE8-rot-none 999.0 APE67-dihe-in -62.85, -24.88 -49.25, -41.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 B 285 253 17 0 0 10 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.6e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTC P53355 5 276 1430.0 ACP:1278 ATPlike None DFGin 6.764 14.238 BLAminus DFGAsp-rot-in -125.03, -178.44 64.54, 79.35 189.71, -29.05 -91.9, 24.57 287.83, 76.0 -66.08, -19.72 in-in in 9.392 Saltbr-in 2.719 HRD-in -72.23, -37.44 57.47, 4.52 in-in-none SNCiin in-none ActLoopNT-in 3.097 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -39.65, -42.12 999.0, -61.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 C 285 259 13 0 0 11 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.6e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3ZXTD P53355 7 276 1430.0 ACP:1277 ATPlike None DFGin 6.866 14.645 BLAminus DFGAsp-rot-in -115.85, 173.32 73.06, 78.3 182.49, 8.53 -92.76, 17.5 283.87, 68.26 -68.46, 25.44 in-in in 9.306 Saltbr-in 2.651 HRD-in -83.16, -46.35 65.92, 13.4 in-in-none SNCiin in-none ActLoopNT-in 3.108 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -20.61 APE8-rot-none 999.0 APE67-dihe-in -90.53, -15.22 -91.11, -7.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.65 0.219 0.285 D 285 245 25 0 0 10 [[13, 275]] 1.0 3zxt Homo sapiens CAMK_DAPK1_HUMAN CAMK 5.6e-95 323.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BC P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.699 13.755 BLAminus DFGAsp-rot-in -145.08, 171.25 61.11, 107.16 194.76, -23.02 -112.51, 31.96 284.23, 68.66 -61.45, -37.77 in-in in 8.935 Saltbr-in 2.757 HRD-in -69.97, -44.39 78.89, -25.31 in-in-none SNCiin in-none ActLoopNT-in 3.064 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.67, -20.62 999.0, 173.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 C 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BD P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.711 13.906 BLAminus DFGAsp-rot-in -145.79, 167.53 68.59, 102.7 191.4, 22.7 -108.4, 30.91 282.62, 68.72 -66.3, -36.77 in-in in 8.983 Saltbr-in 3.408 HRD-in -69.48, -46.19 68.3, 18.38 in-in-none SNCiin in-none ActLoopNT-in 3.29 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -107.53, -10.82 999.0, -167.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 D 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BE P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.837 13.766 BLAminus DFGAsp-rot-in -139.59, 169.54 69.21, 97.38 197.7, -11.64 -104.17, 34.32 282.85, 67.94 -62.67, -38.94 in-in in 8.985 Saltbr-in 2.679 HRD-in -71.5, -45.64 70.77, 10.18 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -99.43, -1.37 999.0, -172.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 E 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BF P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.621 13.688 BLAminus DFGAsp-rot-in -142.07, 170.01 64.83, 98.1 194.23, -8.39 -101.81, 30.72 282.18, 71.32 -65.73, -35.15 in-in in 8.992 Saltbr-in 2.702 HRD-in -80.67, -40.94 69.92, -1.27 in-in-none SNCiin in-none ActLoopNT-in 3.032 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -101.55, -20.21 999.0, -176.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 F 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BG P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.714 14.011 BLAminus DFGAsp-rot-in -137.77, 173.07 72.09, 96.81 198.76, -11.58 -108.03, 29.22 281.02, 70.25 -63.92, -39.04 in-in in 9.1 Saltbr-in 2.657 HRD-in -83.07, -38.78 69.53, -15.76 in-in-none SNCiin in-none ActLoopNT-in 2.998 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -92.27, -2.06 999.0, -177.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 G 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BH P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.783 13.684 BLAminus DFGAsp-rot-in -141.56, 171.1 67.42, 98.81 196.01, -12.12 -106.45, 32.94 281.72, 69.09 -63.41, -39.6 in-in in 8.81 Saltbr-in 2.638 HRD-in -69.99, -38.96 66.77, 4.24 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -98.5, -19.42 999.0, -171.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 H 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BI P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.832 13.615 BLAminus DFGAsp-rot-in -144.83, 172.47 66.99, 98.69 195.79, -5.56 -105.77, 31.32 281.48, 70.34 -64.97, -40.42 in-none in 8.902 Saltbr-none 999.0 HRD-in -71.72, -44.4 66.46, 8.73 none-in-none SNCnin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -89.48, -16.84 999.0, -178.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 I 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BJ P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.585 13.726 BLAminus DFGAsp-rot-in -139.73, 172.93 64.33, 98.73 210.5, -37.24 -104.15, 24.81 279.87, 69.77 -58.59, -39.13 in-in in 8.829 Saltbr-in 2.742 HRD-in -76.49, -44.95 70.08, 8.99 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -95.9, -9.71 999.0, -177.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 J 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BK P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.649 13.886 BLAminus DFGAsp-rot-in -142.88, 173.31 64.15, 96.21 196.33, -13.36 -100.21, 30.51 279.28, 69.33 -63.22, -35.24 in-in in 8.951 Saltbr-in 2.645 HRD-in -75.63, -40.1 74.89, -28.49 in-in-none SNCiin in-none ActLoopNT-in 3.055 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -102.3, -6.38 999.0, -170.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 K 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BL P49137 47 345 400.0 No_ligand No_ligand None DFGin 4.754 13.811 BLAminus DFGAsp-rot-in -149.62, 172.88 62.04, 95.8 192.5, -6.91 -100.2, 29.15 282.37, 69.48 -62.27, -33.8 in-in in 8.809 Saltbr-in 2.54 HRD-in -71.4, -42.73 71.32, 3.36 in-in-none SNCiin in-none ActLoopNT-in 3.086 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -93.48, -10.45 999.0, 179.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 L 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3G P49137 43 342 400.0 No_ligand No_ligand None DFGin 4.403 12.831 BLAminus DFGAsp-rot-in -153.55, -179.38 55.29, 116.19 195.59, -21.19 -117.23, 10.89 291.13, 75.69 -43.5, -24.71 in-in in 8.551 Saltbr-in 3.076 HRD-in -68.58, -34.89 71.69, -26.95 in-in-none SNCiin in-none ActLoopNT-in 3.413 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 G 324 276 24 0 0 14 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPJ P49137 48 328 400.0 No_ligand No_ligand None DFGin 4.458 13.647 BLAminus DFGAsp-rot-in -143.07, -174.18 50.09, 100.81 203.32, 0.75 -101.05, 31.78 269.94, 23.78 -83.21, -13.12 in-in in 8.094 Saltbr-in 3.175 HRD-in -63.4, -41.75 72.41, 26.69 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 J 326 225 56 0 0 18 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 8XX1A P49137 47 364 400.0 No_ligand No_ligand None DFGin 4.495 14.22 BLAminus DFGAsp-rot-in -125.96, 176.04 66.8, 91.73 198.72, -13.37 -96.65, 23.36 281.49, 65.79 -64.79, -14.16 in-in in 9.722 Saltbr-in 2.918 HRD-in -77.76, -52.02 68.77, 17.81 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.55 0.17 0.245 A 318 293 25 0 0 17 [[63, 325]] 1.0 8xx1 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BA P49137 47 345 400.0 05B:1000 Type1 None DFGin 4.793 14.039 BLAminus DFGAsp-rot-in -133.6, 172.77 62.95, 100.31 194.37, 5.15 -104.2, 34.41 278.04, 66.12 -71.39, -34.54 in-in in 9.008 Saltbr-in 2.409 HRD-in -83.09, -47.43 74.93, -6.02 in-in-none SNCiin in-none ActLoopNT-in 3.112 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.52, -24.55 999.0, -179.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 A 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2BB P49137 47 345 400.0 05B:1000 Type1 None DFGin 4.54 13.845 BLAminus DFGAsp-rot-in -142.13, 174.13 65.41, 93.56 196.46, -15.74 -99.51, 29.64 280.69, 67.08 -63.86, -41.52 in-in in 9.102 Saltbr-in 2.593 HRD-in -69.44, -43.13 63.83, 12.28 in-in-none SNCiin in-none ActLoopNT-in 3.017 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -97.51, -10.75 999.0, -173.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.279 0.316 B 318 272 27 0 0 11 [[63, 325]] 1.0 3r2b Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R2YA P49137 46 345 400.0 P4O:3 Type1 None DFGin 4.51 13.529 BLAminus DFGAsp-rot-in -139.75, 177.52 74.44, 98.73 186.53, -3.11 -113.49, 19.9 276.17, 64.33 -51.78, -25.44 in-in in 8.652 Saltbr-in 2.551 HRD-in -79.45, -34.37 67.58, -79.89 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.294 0.334 A 319 259 41 0 0 18 [[63, 325]] 1.0 3r2y Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3R30A P49137 46 345 400.0 CD2:1 Type1 None DFGin 4.276 13.617 BLAminus DFGAsp-rot-in -134.32, 174.77 70.14, 102.44 200.71, -21.75 -110.03, 21.6 275.81, 65.59 -62.22, -28.91 in-in in 8.733 Saltbr-in 2.951 HRD-in -89.69, -43.87 75.38, -83.52 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.284 0.332 A 319 264 36 0 0 16 [[63, 325]] 1.0 3r30 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.3e-80 275.1 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYA P49137 42 346 400.0 B18:1 Type1 None DFGin 4.58 13.976 BLAminus DFGAsp-rot-in -104.95, 167.84 71.31, 102.38 206.14, -43.02 -102.76, 24.4 284.1, 63.71 -59.24, -43.49 in-in in 8.6 Saltbr-in 2.624 HRD-in -76.66, -46.66 68.5, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.747 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -117.11, -34.75 999.0, -126.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 A 324 291 14 0 0 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYB P49137 44 345 400.0 B18:2 Type1 None DFGin 4.541 13.833 BLAminus DFGAsp-rot-in -135.83, 172.16 61.22, 108.34 200.82, -16.15 -113.0, 27.32 291.58, 57.74 -68.8, -9.66 in-in in 8.917 Saltbr-in 2.953 HRD-in -74.89, -51.86 41.3, 40.89 in-in-none SNCiin in-none ActLoopNT-in 2.826 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -68.0, -7.36 999.0, 151.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 B 324 283 19 0 0 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2PZYC P49137 42 359 400.0 STU:3 Type1 None DFGin 4.742 13.584 BLAminus DFGAsp-rot-in -137.32, 155.33 89.76, 83.85 211.43, -10.5 -93.67, 22.39 287.9, 52.26 -71.67, 3.21 in-in in 8.899 Saltbr-in 2.479 HRD-in -82.26, -44.82 71.63, -15.61 in-in-none SNCiin in-none ActLoopNT-in 2.823 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -81.01, -7.47 999.0, -140.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.251 0.313 C 324 307 11 0 0 11 [[63, 325]] 1.0 2pzy Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3A P49137 43 347 400.0 MK2:500 Type1 None DFGin 4.557 13.885 BLAminus DFGAsp-rot-in -135.8, -176.83 67.41, 90.4 187.55, 4.03 -94.59, 16.73 291.73, 73.07 -43.87, -36.09 in-in in 9.109 Saltbr-in 2.597 HRD-in -79.47, -55.59 75.47, 16.47 in-in-none SNCiin in-none ActLoopNT-in 3.09 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.87, 1.13 999.0, 124.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 A 324 288 17 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3B P49137 44 349 400.0 MK2:500 Type1 None DFGin 4.882 13.792 BLAminus DFGAsp-rot-in -132.93, 176.5 69.16, 89.86 190.89, -22.22 -95.19, 24.7 286.31, 75.82 -62.52, -14.87 in-in in 8.556 Saltbr-in 2.527 HRD-in -84.62, -39.61 65.84, 1.69 in-in-none SNCiin in-none ActLoopNT-in 3.033 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -67.96, -17.69 999.0, 172.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 B 324 290 16 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3C P49137 41 345 400.0 MK2:500 Type1 None DFGin 4.718 13.596 BLAminus DFGAsp-rot-in -138.58, -178.81 60.4, 102.94 204.15, -13.59 -104.46, 17.28 285.49, 73.29 -64.82, -5.96 in-in in 8.931 Saltbr-in 2.774 HRD-in -72.28, -46.2 69.4, 2.58 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.35, -6.27 999.0, 125.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 C 324 281 24 0 0 12 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3D P49137 46 342 400.0 MK2:500 Type1 None DFGin 4.505 13.916 BLAminus DFGAsp-rot-in -137.86, 175.26 61.96, 98.93 179.47, -53.85 -99.81, 17.41 286.59, 67.21 -44.85, -25.56 in-in in 8.851 Saltbr-in 2.546 HRD-in -66.46, -43.69 66.23, -1.99 in-in-none SNCiin in-none ActLoopNT-in 2.83 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 D 324 269 28 0 0 15 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3E P49137 44 345 400.0 MK2:500 Type1 None DFGin 4.773 13.965 BLAminus DFGAsp-rot-in -128.92, -178.83 60.96, 110.53 187.18, -6.66 -118.06, 18.13 288.23, 69.3 -53.96, -31.23 in-in in 9.094 Saltbr-in 2.496 HRD-in -67.96, -46.81 65.87, -10.72 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -176.66, -15.58 999.0, -104.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 E 324 287 15 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3F P49137 44 350 400.0 MK2:500 Type1 None DFGin 4.917 13.869 BLAminus DFGAsp-rot-in -134.88, 179.04 76.75, 94.93 197.35, -7.71 -104.84, 22.2 282.85, 74.6 -64.74, -17.47 in-in in 8.995 Saltbr-in 2.731 HRD-in -79.49, -56.77 86.68, 2.72 in-in-none SNCiin in-none ActLoopNT-in 2.94 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.34, 144.53 999.0, 179.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 F 324 293 14 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3H P49137 44 350 400.0 MK2:500 Type1 None DFGin 4.607 13.429 BLAminus DFGAsp-rot-in -138.19, -172.17 57.05, 102.0 200.03, -23.56 -106.68, 27.15 292.81, 72.2 -57.13, -29.31 in-in in 8.726 Saltbr-in 2.696 HRD-in -74.06, -45.37 69.29, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.761 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.73, -8.44 999.0, 98.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 H 324 290 17 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3I P49137 45 356 400.0 MK2:500 Type1 None DFGin 4.689 13.646 BLAminus DFGAsp-rot-in -127.79, 171.26 71.85, 103.11 196.04, -23.06 -106.85, 28.41 284.17, 74.69 -57.35, -27.49 in-in in 8.555 Saltbr-in 2.402 HRD-in -93.72, -30.87 60.32, -1.04 in-in-none SNCiin in-none ActLoopNT-in 2.894 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 I 324 295 17 0 0 13 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3J P49137 43 348 400.0 MK2:500 Type1 None DFGin 4.718 13.802 BLAminus DFGAsp-rot-in -125.72, -175.9 62.46, 84.05 189.07, 7.48 -88.35, 25.1 281.01, 81.77 -82.54, 2.25 in-in in 9.128 Saltbr-in 3.314 HRD-in -78.38, -40.95 69.7, 4.74 in-in-none SNCiin in-none ActLoopNT-in 3.075 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -55.62, -14.39 999.0, 120.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 J 324 288 18 0 0 9 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3K P49137 44 345 400.0 MK2:500 Type1 None DFGin 4.468 13.615 BLAminus DFGAsp-rot-in -140.04, -177.82 52.3, 117.47 196.4, -0.26 -116.32, 11.78 277.13, 82.36 -69.91, 0.72 in-in in 8.958 Saltbr-in 2.78 HRD-in -74.88, -50.37 73.49, 9.77 in-in-none SNCiin in-none ActLoopNT-in 3.333 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 K 324 280 22 0 0 14 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KC3L P49137 42 348 400.0 MK2:500 Type1 None DFGin 4.821 13.855 BLAminus DFGAsp-rot-in -130.63, 174.42 78.71, 90.78 191.84, -0.03 -100.08, 26.64 282.13, 65.04 -59.13, -39.73 in-in in 9.255 Saltbr-in 2.663 HRD-in -90.63, -50.0 65.8, 13.75 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.39, -28.9 999.0, 127.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.233 0.298 L 324 291 16 0 0 11 [[63, 325]] 1.0 3kc3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.5e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPA P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.478 13.85 BLAminus DFGAsp-rot-in -133.98, 174.95 70.89, 89.1 203.2, 12.57 -93.56, 24.83 287.0, 65.27 -55.43, -29.01 in-in in 8.726 Saltbr-in 2.604 HRD-in -85.33, -35.83 65.16, 16.45 in-in-none SNCiin in-none ActLoopNT-in 3.057 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 A 326 283 22 0 0 15 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPB P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.579 13.852 BLAminus DFGAsp-rot-in -138.34, 174.48 73.85, 84.83 201.46, 8.48 -88.84, 30.16 284.72, 60.62 -64.51, -26.86 in-in in 8.707 Saltbr-in 2.535 HRD-in -85.86, -36.04 69.02, 7.05 in-in-none SNCiin in-none ActLoopNT-in 3.061 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -40.26, -29.78 999.0, 121.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 B 326 290 15 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPC P49137 46 350 400.0 P4O:1351 Type1 None DFGin 4.503 13.831 BLAminus DFGAsp-rot-in -133.29, -179.58 64.71, 93.56 209.31, 8.58 -95.15, 25.62 283.97, 64.1 -59.22, -26.85 in-in in 8.767 Saltbr-in 2.926 HRD-in -80.25, -42.98 69.55, 17.83 in-in-none SNCiin in-none ActLoopNT-in 3.088 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -72.2, -7.86 999.0, 175.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 C 326 284 21 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPD P49137 47 350 400.0 P4O:1351 Type1 None DFGin 4.523 13.952 BLAminus DFGAsp-rot-in -137.03, -179.33 64.04, 94.44 196.98, 8.9 -97.23, 21.04 282.65, 66.88 -48.31, -30.44 in-in in 8.832 Saltbr-in 2.714 HRD-in -81.64, -32.5 57.25, 21.38 in-in-none SNCiin in-none ActLoopNT-in 2.967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -148.58, -26.73 999.0, -145.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 D 326 286 18 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPE P49137 44 345 400.0 P4O:1345 Type1 None DFGin 4.724 13.859 BLAminus DFGAsp-rot-in -136.12, 175.35 73.31, 80.12 194.89, 60.07 -82.5, 33.85 283.92, 48.58 -62.96, -45.19 in-in in 8.59 Saltbr-in 2.959 HRD-in -104.14, -29.02 60.75, 18.27 in-in-none SNCiin in-none ActLoopNT-in 2.994 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.62, -21.91 999.0, -152.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 E 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPF P49137 45 350 400.0 P4O:1350 Type1 None DFGin 4.595 13.837 BLAminus DFGAsp-rot-in -132.13, 175.04 70.48, 88.46 202.39, 12.31 -92.2, 24.44 284.08, 67.86 -58.09, -29.79 in-in in 8.685 Saltbr-in 2.569 HRD-in -92.78, -39.0 72.25, 8.97 in-in-none SNCiin in-none ActLoopNT-in 3.082 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -131.16, 4.71 999.0, 165.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 F 326 288 18 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPG P49137 45 350 400.0 P4O:1350 Type1 None DFGin 4.58 13.726 BLAminus DFGAsp-rot-in -138.34, 174.28 71.04, 87.0 198.5, 16.68 -92.84, 24.64 284.29, 71.24 -62.44, -18.91 in-in in 8.739 Saltbr-in 2.523 HRD-in -84.59, -34.64 66.84, 14.57 in-in-none SNCiin in-none ActLoopNT-in 3.05 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.82, -9.25 999.0, -129.44 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 G 326 288 18 0 0 10 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPH P49137 46 347 400.0 P4O:1347 Type1 None DFGin 4.207 13.746 BLAminus DFGAsp-rot-in -134.88, 173.26 70.14, 89.63 202.03, 14.96 -96.59, 27.77 281.47, 58.87 -55.42, -35.35 in-in in 8.808 Saltbr-in 2.548 HRD-in -90.46, -32.76 68.86, 13.14 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 H 326 283 19 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPI P49137 45 350 400.0 P4O:1351 Type1 None DFGin 4.558 13.813 BLAminus DFGAsp-rot-in -140.96, 171.77 69.8, 89.64 196.66, 15.72 -96.08, 24.27 287.29, 67.6 -46.64, -33.04 in-in in 8.736 Saltbr-in 2.735 HRD-in -89.03, -36.29 66.61, 16.32 in-in-none SNCiin in-none ActLoopNT-in 3.06 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -162.11, 79.7 999.0, -145.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 I 326 289 17 0 0 11 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 2JBPK P49137 47 345 400.0 P4O:1345 Type1 None DFGin 4.452 13.779 BLAminus DFGAsp-rot-in -134.43, 174.45 70.58, 87.87 201.71, 8.43 -93.92, 23.8 282.34, 69.99 -55.95, -30.42 in-in in 8.751 Saltbr-in 2.364 HRD-in -80.27, -34.62 66.03, 15.08 in-in-none SNCiin in-none ActLoopNT-in 3.168 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.31 0.215 0.279 K 326 265 34 0 0 19 [[63, 325]] 1.0 2jbp Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.6e-80 275.0 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKA P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.589 13.771 BLAminus DFGAsp-rot-in -126.65, 173.47 71.0, 100.22 207.09, -22.33 -103.09, 25.12 288.21, 68.89 -63.74, -22.07 in-in in 8.808 Saltbr-in 2.833 HRD-in -83.14, -45.68 70.24, 10.29 in-in-none SNCiin in-none ActLoopNT-in 2.999 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 A 334 285 20 0 0 13 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKB P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.574 13.71 BLAminus DFGAsp-rot-in -126.17, 171.53 76.59, 101.21 207.82, -25.8 -106.82, 28.17 283.51, 70.31 -69.3, -20.78 in-in in 8.8 Saltbr-in 2.767 HRD-in -83.32, -42.01 66.8, 9.77 in-in-none SNCiin in-none ActLoopNT-in 2.956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -76.35, -4.83 999.0, -139.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 B 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKC P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.542 13.708 BLAminus DFGAsp-rot-in -127.95, 171.63 72.32, 100.54 205.09, -21.63 -105.36, 27.99 284.77, 68.66 -70.12, -18.04 in-in in 8.818 Saltbr-in 2.76 HRD-in -83.09, -44.86 72.76, 6.72 in-in-none SNCiin in-none ActLoopNT-in 3.021 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -151.92, 3.8 999.0, -64.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 C 334 285 20 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKD P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.552 13.762 BLAminus DFGAsp-rot-in -126.6, 170.16 75.93, 99.4 204.42, -25.6 -106.12, 27.5 286.71, 67.62 -64.49, -22.4 in-in in 8.826 Saltbr-in 2.7 HRD-in -78.53, -45.63 70.0, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.964 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 D 334 283 22 0 0 15 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKE P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.694 BLAminus DFGAsp-rot-in -126.73, 170.86 73.31, 97.65 204.84, -21.04 -100.72, 25.15 284.53, 70.5 -65.36, -19.29 in-in in 8.823 Saltbr-in 2.816 HRD-in -80.98, -44.08 70.38, 5.75 in-in-none SNCiin in-none ActLoopNT-in 3.006 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -110.91, 12.45 999.0, 143.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 E 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKF P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.474 13.706 BLAminus DFGAsp-rot-in -127.85, 174.17 70.83, 96.56 205.6, -21.22 -99.93, 26.89 286.07, 67.62 -67.09, -18.68 in-in in 8.833 Saltbr-in 2.795 HRD-in -80.56, -45.1 72.92, 6.47 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -140.44, 23.91 999.0, -39.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 F 334 284 21 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKG P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.723 BLAminus DFGAsp-rot-in -127.83, 169.9 76.58, 97.3 205.32, -22.33 -103.07, 31.55 285.98, 70.31 -69.86, -24.12 in-in in 8.832 Saltbr-in 2.773 HRD-in -83.6, -42.88 70.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.958 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -35.46 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 G 334 286 19 0 0 12 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKH P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.511 13.701 BLAminus DFGAsp-rot-in -127.46, 173.5 71.38, 99.68 202.17, -21.32 -106.67, 28.02 284.54, 69.36 -65.15, -20.54 in-in in 8.87 Saltbr-in 2.758 HRD-in -82.45, -44.8 70.18, 5.58 in-in-none SNCiin in-none ActLoopNT-in 2.987 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -85.35, 40.25 999.0, -116.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 H 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKI P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.446 13.686 BLAminus DFGAsp-rot-in -127.75, 172.18 73.28, 98.61 204.04, -24.2 -103.78, 25.37 284.35, 71.35 -64.93, -20.35 in-in in 8.771 Saltbr-in 2.738 HRD-in -82.7, -44.15 67.61, 9.58 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -120.54, 0.33 999.0, -77.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 I 334 284 21 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKJ P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.516 13.696 BLAminus DFGAsp-rot-in -125.94, 171.03 73.59, 99.21 206.78, -25.19 -101.22, 24.36 288.17, 72.78 -63.96, -20.62 in-in in 8.837 Saltbr-in 2.841 HRD-in -84.33, -42.62 69.41, 8.71 in-in-none SNCiin in-none ActLoopNT-in 3.076 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 J 334 283 22 0 0 15 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKK P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.495 13.74 BLAminus DFGAsp-rot-in -127.59, 167.14 77.13, 99.42 204.63, -20.86 -103.98, 27.43 284.8, 74.73 -67.14, -17.07 in-in in 8.865 Saltbr-in 2.825 HRD-in -83.96, -44.73 69.47, 7.73 in-in-none SNCiin in-none ActLoopNT-in 3.043 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -86.78, -37.53 999.0, -135.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 K 334 290 15 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3GOKL P49137 46 350 400.0 P4O:1 Type1 None DFGin 4.548 13.687 BLAminus DFGAsp-rot-in -128.35, 173.4 71.1, 97.91 205.12, -19.81 -103.12, 25.34 286.16, 67.54 -60.79, -25.02 in-in in 8.821 Saltbr-in 2.744 HRD-in -84.04, -41.11 66.0, 8.07 in-in-none SNCiin in-none ActLoopNT-in 3.03 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -106.57, 23.19 999.0, 177.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.239 0.258 L 334 284 21 0 0 11 [[63, 325]] 1.0 3gok Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 3.9e-80 274.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KA0A P49137 47 364 400.0 MK3:500 Type1 None DFGin 4.835 13.747 BLAminus DFGAsp-rot-in -134.09, 176.23 64.42, 97.77 191.49, -18.84 -108.27, 26.09 291.3, 65.21 -54.85, -29.31 in-in in 9.224 Saltbr-in 2.84 HRD-in -80.5, -45.65 65.5, 4.98 in-in-none SNCiin in-none ActLoopNT-in 2.817 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E None None XRAY 2.9 0.232 0.265 A 320 279 39 0 0 19 [[63, 325]] 1.0 3ka0 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.9e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKA P49137 42 345 400.0 STU:401 Type1 None DFGin 4.829 13.428 BLAminus DFGAsp-rot-in -122.05, -170.73 42.15, 101.84 213.94, -26.7 -103.58, 19.28 282.18, 65.24 -58.03, -23.15 in-in in 8.716 Saltbr-in 2.473 HRD-in -79.4, -39.47 62.13, 0.83 in-in-none SNCiin in-none ActLoopNT-in 2.683 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.16, 3.04 999.0, 148.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 A 400 290 14 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.9e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKB P49137 44 345 400.0 STU:403 Type1 None DFGin 4.577 13.822 BLAminus DFGAsp-rot-in -128.27, 177.79 53.09, 103.0 212.26, -27.79 -104.87, 20.3 276.49, 67.38 -57.0, -14.43 in-in in 8.647 Saltbr-in 2.563 HRD-in -64.22, -46.2 66.47, 1.25 in-in-none SNCiin in-none ActLoopNT-in 2.82 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.0, -19.87 999.0, 111.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 B 400 283 19 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.9e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 1NXKC P49137 41 357 400.0 STU:401 Type1 None DFGin 4.963 13.774 BLAminus DFGAsp-rot-in -132.89, 178.15 57.47, 93.76 215.49, -32.36 -100.34, 25.49 283.43, 65.32 -70.88, 11.4 in-in in 8.684 Saltbr-in 2.34 HRD-in -75.36, -47.72 65.17, 8.17 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.28, 2.34 999.0, 115.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None MSE94,MSE138,MSE167,MSE246,MSE253,MSE275,MSE281,MSE300,MSE314,MSE320,MSE326,MSE356 XRAY 2.7 0.241 0.274 C 400 306 11 0 0 11 [[63, 325]] 1.0 1nxk Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.9e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3KGAA P49137 47 364 400.0 LX9:365 Type1 None DFGin 4.446 13.678 BLAminus DFGAsp-rot-in -124.87, 174.18 69.13, 92.77 202.49, -31.06 -95.92, 21.23 282.6, 67.95 -62.32, -18.3 in-in in 8.84 Saltbr-in 2.692 HRD-in -73.16, -55.01 73.82, 13.46 in-in-none SNCiin in-none ActLoopNT-in 3.001 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.55 0.183 0.235 A 299 290 7 0 0 0 [[63, 325]] 1.0 3kga Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 2e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3M2WA P49137 47 364 400.0 L8I:1 Type1 None DFGin 4.422 13.673 BLAminus DFGAsp-rot-in -122.16, 170.83 75.18, 88.88 204.51, -16.96 -90.88, 16.66 279.1, 67.47 -57.47, -17.13 in-in in 8.951 Saltbr-in 2.544 HRD-in -74.98, -51.41 69.8, 12.51 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.41 0.187 0.227 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m2w Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 2e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A P49137 47 364 400.0 HGF:365 Type1 None DFGin 4.265 13.765 BLAminus DFGAsp-rot-in -127.28, 170.7 71.87, 101.44 197.54, -33.53 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.26 Saltbr-in 3.091 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m42 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 2e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 6T8XB P49137 45 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.499 13.631 BLAminus DFGAsp-rot-in -129.76, 174.11 63.68, 95.47 216.99, -29.23 -98.99, 32.39 289.86, 73.64 -62.73, -29.4 in-in in 8.644 Saltbr-in 2.799 HRD-in -70.3, -40.77 63.38, 5.93 in-in-none SNCiin in-none ActLoopNT-in 2.983 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.94 APE8-rot-in 320.74 APE67-dihe-in -57.79, -34.07 -54.58, -48.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 B 319 276 9 0 0 9 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.8e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK2 MAPK2_HUMAN 6T8XC P49137 44 329 400.0 B97:401,MW8:403 Type1,Allosteric None DFGin 4.542 13.623 BLAminus DFGAsp-rot-in -130.94, 173.46 63.89, 94.6 218.75, -29.08 -98.12, 31.68 290.58, 73.54 -62.98, -29.52 in-in in 8.608 Saltbr-in 2.836 HRD-in -74.07, -44.94 68.64, 5.14 in-in-none SNCiin in-none ActLoopNT-in 2.985 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 123.58 APE8-rot-in 319.09 APE67-dihe-in -57.21, -34.86 -54.2, -47.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T222E,T334E None None XRAY 2.81 0.229 0.247 C 319 276 10 0 0 10 [[63, 325]] 1.0 6t8x Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 7.8e-80 273.9 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK MAPKAPK3 MAPK3_HUMAN 3R1NA Q16644 33 348 382.0 05B:1 Type1 None DFGin 4.896 13.723 BLAminus DFGAsp-rot-in -136.67, 172.77 78.51, 90.83 198.42, -17.05 -101.61, 24.05 288.26, 79.22 -63.01, -24.62 in-in in 8.725 Saltbr-in 2.828 HRD-in -78.68, -50.93 70.53, 6.79 in-in-none SNCiin in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.09 0.216 0.258 A 317 274 42 0 0 17 [[43, 304]] 1.0 3r1n Homo sapiens CAMK_MAPKAPK3_HUMAN CAMK 6.4e-79 270.9 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 3SHEA Q16644 33 348 382.0 I85:350 Type1 None DFGin 5.064 13.713 BLAminus DFGAsp-rot-in -121.04, 179.13 78.75, 86.24 204.72, -17.65 -103.12, 28.39 293.82, 81.07 -68.69, -16.03 in-in in 8.803 Saltbr-in 2.712 HRD-in -78.85, -52.74 72.19, 13.35 in-in-none SNCiin in-none ActLoopNT-in 2.961 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.248 0.271 A 317 270 46 0 0 18 [[43, 304]] 1.0 3she Homo sapiens CAMK_MAPKAPK3_HUMAN CAMK 6.4e-79 270.9 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 3FHRA Q16644 33 349 382.0 P4O:1 Type1 None DFGin 4.699 13.823 BLAminus DFGAsp-rot-in -141.35, -177.59 72.02, 91.12 192.61, -9.61 -99.99, 27.14 290.18, 82.64 -72.4, -18.76 in-in in 8.535 Saltbr-in 2.724 HRD-in -82.05, -51.65 76.12, 7.07 in-in-none SNCiin in-none ActLoopNT-in 2.908 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.228 0.267 A 336 273 44 0 0 18 [[43, 304]] 1.0 3fhr Homo sapiens CAMK_MAPKAPK3_HUMAN CAMK 7.8e-79 270.6 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 3FXWA Q16644 33 349 382.0 F10:1 Type1 None DFGin 4.695 13.736 BLAminus DFGAsp-rot-in -136.8, -179.26 78.7, 91.06 188.52, -6.3 -98.97, 26.29 291.45, 74.65 -64.27, -27.51 in-in in 8.569 Saltbr-in 2.597 HRD-in -87.39, -52.65 79.46, 4.69 in-in-none SNCiin in-none ActLoopNT-in 2.842 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.235 0.277 A 336 271 46 0 0 19 [[43, 304]] 1.0 3fxw Homo sapiens CAMK_MAPKAPK3_HUMAN CAMK 7.8e-79 270.6 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MAPKAPK3 MAPK3_HUMAN 7NRBA Q16644 33 349 382.0 P4O:401 Type1 None DFGin 4.627 13.783 BLAminus DFGAsp-rot-in -148.65, -177.31 69.63, 94.52 195.71, -16.78 -103.08, 30.24 293.93, 81.96 -68.85, -25.17 in-in in 8.511 Saltbr-in 2.629 HRD-in -79.95, -52.31 74.88, 5.61 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.214 0.235 A 336 273 44 0 0 18 [[43, 304]] 1.0 7nrb Homo sapiens CAMK_MAPKAPK3_HUMAN CAMK 7.8e-79 270.6 1 256 256 186 187 188 190 192 73 84 88 163 165 164 166 224 212 207 206 205 204 203 202 201 119 MAP kinase-activated protein kinase 3
CAMK MELK MELK_HUMAN 5IH8A Q14680 3 327 651.0 6BJ:60401 Type1 None DFGin 6.899 15.015 BLAminus DFGAsp-rot-in -123.97, 176.03 57.35, 81.53 200.37, -10.26 -98.01, 22.13 281.32, 75.72 -67.27, -27.19 in-in in 8.68 Saltbr-in 2.708 HRD-in -68.78, -51.48 74.83, -1.98 in-in-none SNCiin in-none ActLoopNT-in 2.925 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -5.67 APE8-rot-in 289.51 APE67-dihe-in -61.1, -22.21 -55.23, -38.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.178 0.2 A 335 305 20 0 0 14 [[11, 263]] 1.0 5ih8 Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.939 15.146 BLAminus DFGAsp-rot-in -123.48, 176.08 58.26, 79.91 204.43, -22.81 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.72 Saltbr-in 2.587 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335 307 18 0 0 14 [[11, 263]] 1.0 5ih9 Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 5IHAA Q14680 3 327 651.0 6BE:60401 Type1 None DFGin 6.829 15.042 BLAminus DFGAsp-rot-in -120.87, 177.4 55.95, 85.64 206.84, -17.74 -102.14, 23.45 281.65, 80.18 -67.54, -28.51 in-in in 8.842 Saltbr-in 2.632 HRD-in -71.43, -49.46 70.45, 4.23 in-in-none SNCiin in-none ActLoopNT-in 3.034 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.72 APE8-rot-in 296.55 APE67-dihe-in -57.19, -26.87 -59.91, -43.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.175 0.202 A 335 302 23 0 0 14 [[11, 263]] 1.0 5iha Homo sapiens CAMK_MELK_HUMAN CAMK 1e-88 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 6GVXA Q14680 1 333 651.0 TAK:60402 Type1 None DFGin 6.711 15.26 BLAminus DFGAsp-rot-in -125.4, 178.58 58.73, 78.31 202.87, -15.61 -98.95, 27.88 285.76, 76.62 -69.49, -24.6 in-in in 9.004 Saltbr-in 2.908 HRD-in -62.31, -45.72 65.24, 14.32 in-in-none SNCiin in-none ActLoopNT-in 2.869 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -86.88 APE9-dihe-na -85.92, -154.54 APE8-dihe-in -73.43, 134.24 APE8-rot-in 297.0 APE67-dihe-in -62.55, -20.46 -61.75, -38.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.519 APE9-dist-in 4.486 None None None XRAY 2.24 0.205 0.24 A 344 311 15 0 0 7 [[11, 263]] 1.0 6gvx Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4BKYA Q14680 3 333 651.0 82B:1334 Type1 None DFGin 6.861 14.789 BLAminus DFGAsp-rot-in -126.95, 173.05 62.71, 72.79 206.89, -23.31 -92.87, 16.6 286.13, 76.41 -58.61, -28.78 in-in in 8.592 Saltbr-in 2.597 HRD-in -70.13, -52.15 72.52, 2.08 in-in-none SNCiin in-none ActLoopNT-in 3.012 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -30.73 APE8-rot-in 283.32 APE67-dihe-in -55.55, -24.59 -55.8, -42.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.83 0.204 0.223 A 347 311 20 0 0 15 [[11, 263]] 1.0 4bky Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2TB Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.517 15.482 BLAminus DFGAsp-rot-in -134.63, -178.27 55.46, 74.9 201.32, 12.32 -94.29, 23.67 286.62, 83.25 -66.74, -35.72 in-in in 9.149 Saltbr-in 2.788 HRD-in -58.96, -48.62 71.55, 4.62 in-in-none SNCiin in-none ActLoopNT-in 2.809 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -118.25 APE9-dihe-na 126.7, -132.88 APE8-dihe-in -115.61, 136.66 APE8-rot-none 999.0 APE67-dihe-in -51.25, -29.04 -60.65, -47.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.181 APE9-dist-in 3.724 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 B 356 322 11 0 0 6 [[11, 263]] 1.0 4d2t Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2TC Q14680 1 333 651.0 3I7:61334 Type1 None DFGin 6.63 15.594 BLAminus DFGAsp-rot-in -134.25, 179.33 57.66, 74.82 201.0, 12.54 -93.87, 24.92 285.83, 82.78 -70.22, -25.26 in-in in 9.153 Saltbr-in 2.796 HRD-in -57.46, -50.13 71.26, 4.63 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -131.47 APE8-dihe-in -117.46, 135.5 APE8-rot-none 999.0 APE67-dihe-in -52.13, -27.45 -60.57, -47.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.685 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 C 356 313 20 0 0 13 [[11, 263]] 1.0 4d2t Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2TD Q14680 3 333 651.0 3I7:61334 Type1 None DFGin 6.495 15.537 BLAminus DFGAsp-rot-in -130.9, 164.85 58.81, 83.3 212.3, -5.47 -99.74, 25.07 285.57, 83.05 -62.72, -39.18 in-in in 9.267 Saltbr-in 2.798 HRD-in -58.57, -49.69 71.95, 4.52 in-in-none SNCiin in-none ActLoopNT-in 2.797 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -132.43 APE8-dihe-in -116.12, 138.43 APE8-rot-none 999.0 APE67-dihe-in -52.16, -28.22 -60.64, -47.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.733 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.7 0.273 0.34 D 356 319 8 0 0 8 [[11, 263]] 1.0 4d2t Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2VA Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.792 15.704 BLAminus DFGAsp-rot-in -128.16, -178.54 46.67, 81.9 183.92, 40.77 -94.66, 26.37 289.35, 79.84 -48.93, -31.86 in-in in 9.388 Saltbr-in 2.87 HRD-in -64.57, -46.97 77.06, -5.55 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.0 APE8-dihe-in -89.53, 134.8 APE8-rot-none 999.0 APE67-dihe-in -53.64, -18.08 -71.01, -44.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.591 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 A 356 312 21 0 0 15 [[11, 263]] 1.0 4d2v Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2VC Q14680 1 333 651.0 45R:61334 Type1 None DFGin 6.773 15.768 BLAminus DFGAsp-rot-in -127.7, -179.29 47.99, 81.71 183.86, 42.38 -95.83, 24.05 288.88, 80.0 -69.4, -23.25 in-in in 9.391 Saltbr-in 2.866 HRD-in -64.65, -48.16 76.02, -3.72 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -147.18 APE8-dihe-in -89.76, 137.08 APE8-rot-none 999.0 APE67-dihe-in -54.65, -16.89 -71.35, -44.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.61 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 C 356 316 17 0 0 13 [[11, 263]] 1.0 4d2v Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2VD Q14680 3 333 651.0 45R:61334 Type1 None DFGin 6.757 15.657 BLAminus DFGAsp-rot-in -128.1, -177.36 48.27, 80.83 184.73, 41.85 -95.04, 26.93 289.26, 79.87 -56.22, -36.0 in-in in 9.438 Saltbr-in 2.847 HRD-in -64.33, -48.39 77.06, -3.92 in-in-none SNCiin in-none ActLoopNT-in 3.383 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -146.49 APE8-dihe-in -88.59, 137.31 APE8-rot-none 999.0 APE67-dihe-in -54.66, -16.96 -72.15, -45.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.648 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.45 0.294 0.357 D 356 318 8 0 0 8 [[11, 263]] 1.0 4d2v Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2WC Q14680 1 333 651.0 NF5:1334 Type1 None DFGin 6.857 15.642 BLAminus DFGAsp-rot-in -123.79, 178.59 60.65, 71.55 200.51, -15.56 -90.39, 19.57 282.34, 80.84 -69.3, -20.74 in-in in 8.998 Saltbr-in 2.743 HRD-in -74.38, -48.87 73.02, -0.95 in-in-none SNCiin in-none ActLoopNT-in 3.019 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.96 APE8-dihe-in -49.29, 128.09 APE8-rot-none 999.0 APE67-dihe-in -59.65, -22.66 -56.52, -44.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.747 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 1.92 0.203 0.247 C 356 313 20 0 0 13 [[11, 263]] 1.0 4d2w Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMPD Q14680 2 333 651.0 5QM:1334 Type1 None DFGin 6.868 15.538 BLAminus DFGAsp-rot-in -128.98, 172.85 60.45, 81.99 201.17, -28.33 -100.97, 13.83 278.54, 87.38 -58.85, -32.32 in-in in 9.123 Saltbr-in 2.758 HRD-in -66.2, -47.15 69.3, -6.44 in-in-none SNCiin in-none ActLoopNT-in 2.885 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -155.38 APE8-dihe-in -63.2, 133.11 APE8-rot-none 999.0 APE67-dihe-in -59.09, -26.16 -63.77, -40.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.238 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 D 356 321 7 0 0 7 [[11, 263]] 1.0 4ump Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PA Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.767 15.436 BLAminus DFGAsp-rot-in -121.57, -178.43 43.06, 87.01 184.42, 58.42 -96.75, 36.15 287.09, 78.41 -62.79, -28.68 in-in in 9.863 Saltbr-in 3.489 HRD-in -65.09, -43.36 70.33, -2.48 in-in-none SNCiin in-none ActLoopNT-in 3.474 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.47 APE8-dihe-in -63.07, 132.76 APE8-rot-none 999.0 APE67-dihe-in -56.46, -25.28 -62.72, -43.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.13 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 A 356 313 20 0 0 14 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PB Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.804 15.267 BLAminus DFGAsp-rot-in -116.15, -179.55 42.83, 87.18 181.89, 58.54 -95.49, 33.61 286.93, 77.41 -73.57, -28.71 in-in in 9.691 Saltbr-in 3.386 HRD-in -66.38, -43.95 69.75, -0.06 in-in-none SNCiin in-none ActLoopNT-in 3.155 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnii APE10-dihe-na 999.0, -89.14 APE9-dihe-na 110.05, -162.04 APE8-dihe-in -67.8, 135.44 APE8-rot-none 999.0 APE67-dihe-in -55.82, -25.74 -63.48, -45.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.356 APE9-dist-in 4.242 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 B 356 323 10 0 0 6 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PC Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.77 15.235 BLAminus DFGAsp-rot-in -121.44, -178.21 43.87, 86.48 182.86, 59.76 -97.16, 31.68 287.92, 77.16 -71.21, -25.62 in-in in 9.58 Saltbr-in 3.254 HRD-in -64.88, -44.62 70.79, 0.06 in-in-none SNCiin in-none ActLoopNT-in 2.868 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.51 APE8-dihe-in -65.31, 136.43 APE8-rot-none 999.0 APE67-dihe-in -56.72, -24.92 -63.56, -46.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 C 356 315 18 0 0 13 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4D2PD Q14680 1 333 651.0 6Z7:61334 Type1.5_Back None DFGin 6.778 15.262 BLAminus DFGAsp-rot-in -121.01, -179.74 44.13, 87.06 183.13, 57.86 -96.7, 34.13 287.58, 76.33 -72.88, -28.13 in-in in 9.882 Saltbr-in 3.47 HRD-in -66.46, -43.59 69.94, 0.8 in-in-none SNCiin in-none ActLoopNT-in 3.091 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.68 APE8-dihe-in -65.17, 134.89 APE8-rot-none 999.0 APE67-dihe-in -55.96, -25.2 -65.21, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.206 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.55 0.237 0.312 D 356 317 7 0 0 7 [[11, 263]] 1.0 4d2p Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMPA Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.778 15.294 BLAminus DFGAsp-rot-in -116.7, -176.8 54.54, 81.11 206.62, -29.43 -105.57, 22.84 278.1, 82.0 -64.7, -26.81 in-in in 9.187 Saltbr-in 2.741 HRD-in -68.68, -33.57 59.29, 16.14 in-in-none SNCiin in-none ActLoopNT-in 3.404 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.18 APE8-dihe-in -64.9, 131.94 APE8-rot-none 999.0 APE67-dihe-in -58.2, -28.41 -61.43, -40.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.989 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 A 356 313 20 0 0 14 [[11, 263]] 1.0 4ump Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMPC Q14680 1 333 651.0 5QM:1334 Type1.5_Back None DFGin 6.803 15.543 BLAminus DFGAsp-rot-in -123.91, -179.28 56.39, 85.45 196.81, -31.0 -103.47, 13.92 280.5, 85.56 -60.17, -35.76 in-in in 9.051 Saltbr-in 2.737 HRD-in -71.35, -45.77 70.39, -10.7 in-in-none SNCiin in-none ActLoopNT-in 2.907 ActLoopCT-none nonTYR APEdihe_aaini APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.15 APE8-dihe-in -66.96, 131.15 APE8-rot-none 999.0 APE67-dihe-in -60.1, -27.83 -60.42, -43.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.587 T167A,S171A,N213T,V214A,M215A,Y218V,K219A None None XRAY 2.3 0.238 0.291 C 356 311 22 0 0 13 [[11, 263]] 1.0 4ump Homo sapiens CAMK_MELK_HUMAN CAMK 4.7e-87 297.7 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM2 PIM2_HUMAN 2IWIA Q9P1W9 32 288 311.0 HB1:1289 Type1 None DFGin 6.219 14.218 BLAminus DFGAsp-rot-in -110.81, 164.83 68.74, 90.42 191.03, -13.99 -99.66, 29.13 287.09, 66.88 -61.46, -39.74 in-none in 8.56 Saltbr-none 999.0 HRD-na-T -76.62, -35.93 58.51, 10.21 none-in-in SNCnii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -92.36, -16.65 APE9-dihe-na -63.74, 173.12 APE8-dihe-in -77.0, 156.24 APE8-rot-in 263.75 APE67-dihe-in -52.18, -29.37 -50.11, -60.45 APE12-dist-in 9.015 APE11-dist-in 9.245 APE10-dist-in 4.898 APE9-dist-in 5.68 None None None XRAY 2.8 0.244 0.289 A 312 244 13 0 0 0 [[32, 286]] 1.0 2iwi Homo sapiens CAMK_PIM2_HUMAN CAMK 5.7e-61 212.0 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK PIM2 PIM2_HUMAN 2IWIB Q9P1W9 22 287 311.0 HB1:1288 Type1 None DFGin 6.13 13.843 BLAminus DFGAsp-rot-in -118.57, 161.53 68.46, 93.4 199.54, -29.82 -100.16, 25.47 292.3, 69.44 -61.98, -35.07 in-none in 8.602 Saltbr-none 999.0 HRD-na-T -73.52, -38.58 59.85, 10.52 none-in-in SNCnii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -94.66, -16.48 APE9-dihe-na -63.71, 174.13 APE8-dihe-in -79.54, 156.69 APE8-rot-in 292.9 APE67-dihe-in -51.11, -31.79 -54.32, -53.14 APE12-dist-in 8.851 APE11-dist-in 9.327 APE10-dist-in 4.895 APE9-dist-in 5.671 None None None XRAY 2.8 0.244 0.289 B 312 249 17 0 0 0 [[32, 286]] 1.0 2iwi Homo sapiens CAMK_PIM2_HUMAN CAMK 5.7e-61 212.0 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK PIM2 PIM2_HUMAN 4X7QA Q9P1W9 32 287 311.0 3YR:401 Type1 None DFGin 6.467 14.664 BLAminus DFGAsp-rot-in -126.1, 165.99 65.04, 79.85 197.65, 17.52 -95.42, 6.54 281.8, 81.22 -72.84, 17.13 in-in in 8.3 Saltbr-in 2.568 HRD-na-T -75.97, -46.2 69.29, -4.22 in-in-none SNCiin in-none ActLoopNT-in 3.014 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 21.71 APE9-dihe-na -87.64, 176.68 APE8-dihe-in -77.74, 129.43 APE8-rot-in 298.56 APE67-dihe-in -70.69, -7.37 -67.84, -36.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.25 APE9-dist-in 4.16 None None None XRAY 2.33 0.199 0.258 A 312 217 39 0 0 10 [[32, 286]] 1.0 4x7q Homo sapiens CAMK_PIM2_HUMAN CAMK 5.7e-61 212.0 1 256 256 181 182 183 185 187 61 83 87 160 162 161 163 220 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase pim-2
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.469 14.143 BLAminus DFGAsp-rot-in -120.9, 173.77 65.89, 86.51 190.94, 16.64 -96.46, 22.04 287.59, 69.84 -51.57, -39.89 in-in in 8.867 Saltbr-in 2.809 HRD-in -86.24, -52.51 73.21, 10.94 in-in-none SNCiin in-none ActLoopNT-in 2.989 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 A 325 282 33 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.769 14.211 BLAminus DFGAsp-rot-in -127.01, 177.83 61.12, 80.37 199.4, -13.68 -96.03, 24.29 287.04, 69.05 -65.01, -20.75 in-in in 8.872 Saltbr-in 2.738 HRD-in -80.02, -49.37 72.67, 1.66 in-in-none SNCiin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 B 325 289 26 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN6A O75582 415 729 802.0 No_ligand No_ligand None DFGin 5.611 14.26 BLAminus DFGAsp-rot-in -118.28, 175.46 61.9, 79.38 196.64, -1.73 -91.95, 22.39 287.08, 72.16 -57.81, -30.08 in-in in 8.55 Saltbr-in 2.631 HRD-in -82.27, -48.41 76.43, -4.89 in-in-none SNCiin in-none ActLoopNT-in 2.9 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.219 0.263 A 325 282 33 0 0 18 [[49, 318], [423, 687]] 2.0 3kn6 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN6B O75582 415 729 802.0 No_ligand No_ligand None DFGin 5.71 14.3 BLAminus DFGAsp-rot-in -116.55, 177.27 57.59, 82.82 198.62, -5.64 -93.95, 22.75 286.03, 67.47 -63.56, -27.92 in-in in 8.613 Saltbr-in 2.634 HRD-in -79.95, -51.48 73.92, -1.2 in-in-none SNCiin in-none ActLoopNT-in 2.946 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.219 0.263 B 325 288 27 0 0 18 [[49, 318], [423, 687]] 2.0 3kn6 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP4A O75582 415 723 802.0 O1K:60900 Type1 None DFGin 5.474 14.593 BLAminus DFGAsp-rot-in -122.74, 179.98 59.98, 77.55 205.02, -32.94 -82.97, 36.44 285.0, 70.28 -65.72, -47.91 in-in in 8.387 Saltbr-in 2.923 HRD-in -87.02, -45.05 64.57, 8.0 in-in-none SNCiin in-none ActLoopNT-in 3.071 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.198 0.271 A 306 273 16 0 0 0 [[49, 318], [423, 687]] 2.0 7up4 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP4B O75582 415 728 802.0 O1K:60900 Type1 None DFGin 5.701 14.66 BLAminus DFGAsp-rot-in -127.03, -172.02 45.7, 88.1 195.42, 16.34 -96.74, 28.49 286.1, 79.63 -64.65, -32.76 in-in in 8.434 Saltbr-in 2.835 HRD-in -85.31, -45.96 68.72, 10.44 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.198 0.271 B 306 286 8 0 0 0 [[49, 318], [423, 687]] 2.0 7up4 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP5A O75582 415 723 802.0 O1R:60901 Type1 None DFGin 5.664 14.714 BLAminus DFGAsp-rot-in -122.63, -178.53 60.51, 88.42 188.78, 66.22 -101.56, 29.57 282.99, 77.86 -68.32, -33.69 in-in in 8.538 Saltbr-in 3.114 HRD-in -71.92, -47.31 60.46, 18.29 in-in-none SNCiin in-none ActLoopNT-in 2.798 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.208 0.268 A 306 275 14 0 0 0 [[49, 318], [423, 687]] 2.0 7up5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP5B O75582 415 728 802.0 O1R:60901 Type1 None DFGin 5.781 14.616 BLAminus DFGAsp-rot-in -124.33, -175.52 59.67, 87.86 192.53, 10.39 -104.08, 30.8 286.5, 78.36 -71.29, -27.63 in-in in 8.485 Saltbr-in 2.974 HRD-in -73.09, -49.84 65.25, 16.76 in-in-none SNCiin in-none ActLoopNT-in 2.978 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.208 0.268 B 306 286 8 0 0 0 [[49, 318], [423, 687]] 2.0 7up5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP7A O75582 415 725 802.0 1LE:60900 Type1 None DFGin 5.591 14.211 BLAminus DFGAsp-rot-in -125.22, 177.51 60.32, 85.8 198.11, 5.63 -95.44, 29.21 285.45, 74.04 -73.73, -22.53 in-in in 8.422 Saltbr-in 2.746 HRD-in -73.08, -52.28 71.87, 3.1 in-in-none SNCiin in-none ActLoopNT-in 3.141 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.188 0.244 A 306 277 11 0 0 0 [[49, 318], [423, 687]] 2.0 7up7 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP7B O75582 416 728 802.0 1LE:60900 Type1 None DFGin 5.652 14.149 BLAminus DFGAsp-rot-in -125.82, 177.98 60.43, 85.41 197.06, 5.16 -97.8, 28.34 286.39, 74.01 -73.9, -22.32 in-in in 8.511 Saltbr-in 2.727 HRD-in -73.39, -51.12 72.22, 2.73 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.188 0.244 B 306 280 10 0 0 0 [[49, 318], [423, 687]] 2.0 7up7 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP8A O75582 415 723 802.0 O10:60900 Type1 None DFGin 5.47 14.555 BLAminus DFGAsp-rot-in -126.38, -176.54 57.89, 82.8 195.96, -2.69 -93.17, 31.16 285.14, 65.13 -71.78, -14.66 in-in in 8.658 Saltbr-in 3.008 HRD-in -69.8, -58.15 74.74, 5.63 in-in-none SNCiin in-none ActLoopNT-in 3.121 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.194 0.263 A 306 273 16 0 0 0 [[49, 318], [423, 687]] 2.0 7up8 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP8B O75582 415 727 802.0 O10:60900 Type1 None DFGin 5.691 14.48 BLAminus DFGAsp-rot-in -127.35, -177.88 56.29, 83.72 198.2, -2.2 -95.23, 31.38 286.27, 65.22 -70.45, -14.23 in-in in 8.552 Saltbr-in 2.901 HRD-in -70.46, -59.48 76.49, 5.89 in-in-none SNCiin in-none ActLoopNT-in 3.08 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.194 0.263 B 306 280 13 0 0 0 [[49, 318], [423, 687]] 2.0 7up8 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 7UP6A O75582 416 707 802.0 SUU:60900,OXM:60901,OXM:60902 Type1,Allosteric,Allosteric None DFGin 5.591 13.8 BLAminus DFGAsp-rot-in -126.35, 175.79 57.79, 81.54 203.23, -3.48 -83.37, 27.18 291.21, 78.77 -62.37, -28.83 in-in in 8.371 Saltbr-in 2.52 HRD-in -72.11, -52.65 71.73, 7.94 in-in-none SNCiin in-none ActLoopNT-in 2.853 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.17 0.209 A 306 256 13 0 0 0 [[49, 318], [423, 687]] 2.0 7up6 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 3.1e-47 252.0 5 149 229 564 565 566 568 570 455 468 472 541 543 542 544 604 0 0 0 0 0 0 0 0 499 Ribosomal protein S6 kinase alpha-5
CAMK STK17B ST17B_HUMAN 7Q7CA O94768 25 297 372.0 ADP:60402 ATPlike None DFGin 5.672 13.983 BLAminus DFGAsp-rot-in -146.28, 174.77 69.66, 80.54 200.88, -18.05 -103.01, 24.61 291.62, 86.01 -65.04, -13.43 in-in in 9.403 Saltbr-in 3.35 HRD-in -84.64, -49.74 76.32, -16.47 in-in-none SNCiin in-none ActLoopNT-in 3.297 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.13 APE8-rot-in 309.53 APE67-dihe-in -65.37, -16.14 -54.33, -43.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.21 0.238 A 327 265 8 0 0 8 [[32, 293]] 1.0 7q7c Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 CSNK1A1 KC1A_HUMAN 8G66F P48729 10 303 337.0 No_ligand No_ligand None DFGin 6.691 14.706 BLAminus DFGAsp-rot-in -136.03, -174.06 61.85, 69.19 185.42, -2.63 -78.04, 10.68 292.24, 95.4 -51.34, -23.46 in-in in 7.682 Saltbr-in 3.377 HRD-in -83.58, -49.33 62.86, 12.64 in-in-none SNCiin in-none ActLoopNT-in 2.983 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -102.78, 114.36 APE9-dihe-na 120.82, 175.64 APE8-dihe-in -62.9, 131.79 APE8-rot-none 999.0 APE67-dihe-in -50.33, -44.66 -60.52, -40.89 APE12-dist-in 12.958 APE11-dist-in 11.933 APE10-dist-in 6.404 APE9-dist-in 3.831 None None None XRAY 3.45 0.215 0.272 F 341 294 0 0 0 0 [[17, 283]] 1.0 8g66 Homo sapiens CK1_CSNK1A1_HUMAN CK1 2.8e-121 409.9 1 261 261 156 157 158 160 162 46 60 64 133 135 134 136 203 191 186 185 184 183 182 181 180 91 Casein kinase I isoform alpha
CK1 CSNK1D KC1D_HUMAN 6RU6B P48730 3 294 415.0 ACP:60301 ATPlike None DFGin 6.59 15.156 BLAminus DFGAsp-rot-in -129.63, 177.25 73.9, 71.28 198.6, 0.34 -92.31, 21.27 283.76, 74.29 -58.84, -31.38 in-in in 7.818 Saltbr-in 2.796 HRD-in -76.32, -55.32 74.02, 14.82 in-in-none SNCiin in-none ActLoopNT-in 2.86 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -126.17 APE8-dihe-in -104.51, 127.76 APE8-rot-in 311.88 APE67-dihe-in -57.59, -35.09 -58.93, -44.33 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.941 None None None XRAY 2.05 0.213 0.257 B 296 278 14 0 0 8 [[9, 275]] 1.0 6ru6 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 3UYTD P48730 4 294 415.0 0CK:295 Type1 None DFGin 6.058 14.902 BLAminus DFGAsp-rot-in -125.11, 171.89 69.6, 107.56 220.41, -55.79 -115.59, 22.0 279.81, 112.96 -71.13, -36.34 in-in in 8.444 Saltbr-in 3.03 HRD-in -87.06, -44.31 72.64, -9.74 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 157.15 APE9-dihe-na 110.54, 179.72 APE8-dihe-in -77.04, 125.8 APE8-rot-in 336.84 APE67-dihe-in -54.65, -24.61 -55.67, -34.73 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.132 APE9-dist-in 4.59 None None None XRAY 2.0 0.244 0.264 D 296 268 23 0 0 16 [[9, 275]] 1.0 3uyt Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 5OKTB P48730 4 294 415.0 9XK:301 Type1 None DFGin 6.127 14.635 BLAminus DFGAsp-rot-in -133.48, 170.79 70.83, 88.65 206.05, -38.56 -98.93, 18.4 294.6, 95.75 -62.62, -31.39 in-in in 7.966 Saltbr-in 2.832 HRD-in -78.04, -48.78 74.52, -0.37 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -70.45 APE9-dihe-na -87.34, -162.07 APE8-dihe-in -74.91, 135.72 APE8-rot-in 311.98 APE67-dihe-in -57.97, -40.98 -67.96, -35.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.351 APE9-dist-in 3.835 None TPO220 TPO220 XRAY 2.13 0.194 0.221 B 314 282 9 0 0 9 [[9, 275]] 1.0 5okt Homo sapiens CK1_CSNK1D_HUMAN CK1 2e-122 413.6 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 7NZYB P48730 2 294 415.0 UX2:301 Type1 None DFGin 6.558 14.882 BLAminus DFGAsp-rot-in -133.2, 168.2 69.93, 96.11 199.68, -46.4 -104.78, 25.32 292.5, 81.62 -64.88, -24.78 in-in in 8.136 Saltbr-in 2.965 HRD-in -79.22, -50.76 76.11, 7.31 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.52, -73.6 APE9-dihe-na -68.02, -150.38 APE8-dihe-in -91.32, 139.07 APE8-rot-in 311.34 APE67-dihe-in -57.14, -39.91 -68.37, -36.29 APE12-dist-none 999.0 APE11-dist-in 11.813 APE10-dist-in 6.872 APE9-dist-in 3.731 None TPO220 TPO220 XRAY 1.85 0.205 0.229 B 314 286 7 0 0 7 [[9, 275]] 1.0 7nzy Homo sapiens CK1_CSNK1D_HUMAN CK1 2e-122 413.6 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 4KB8A P48730 3 293 415.0 1QN:401 Type1 None DFGin 5.98 14.795 BLAminus DFGAsp-rot-in -126.76, 172.83 67.65, 98.79 214.37, -58.5 -108.65, 18.05 291.14, 100.67 -60.78, -33.86 in-in in 8.264 Saltbr-in 2.885 HRD-in -74.47, -48.24 76.4, -6.59 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -159.46 APE8-dihe-in -103.07, 128.56 APE8-rot-in 304.05 APE67-dihe-in -56.21, -39.45 -54.48, -41.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.597 None None None XRAY 1.95 0.207 0.232 A 331 265 26 0 0 18 [[9, 275]] 1.0 4kb8 Homo sapiens CK1_CSNK1D_HUMAN CK1 2.4e-122 413.4 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 4KBAA P48730 3 293 415.0 1QM:401 Type1 None DFGin 5.942 14.713 BLAminus DFGAsp-rot-in -128.03, 172.49 65.02, 105.13 210.65, -54.47 -114.85, 19.06 291.3, 105.5 -62.25, -33.76 in-in in 8.12 Saltbr-in 2.814 HRD-in -73.17, -51.42 78.43, -6.31 in-in-none SNCiin in-none ActLoopNT-in 2.918 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.81 APE8-dihe-in -100.61, 126.43 APE8-rot-in 305.06 APE67-dihe-in -59.74, -39.86 -55.88, -36.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.561 None None None XRAY 1.98 0.21 0.237 A 331 263 28 0 0 18 [[9, 275]] 1.0 4kba Homo sapiens CK1_CSNK1D_HUMAN CK1 2.4e-122 413.4 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1G1 KC1G1_HUMAN 2CMWA Q9HCP0 44 339 422.0 OLP:1340,OLP:1341,OLP:1342 Type1,Allosteric,Allosteric None DFGin 6.558 15.115 BLAminus DFGAsp-rot-in -129.0, 174.5 61.96, 82.76 201.36, -13.18 -97.59, 18.98 283.72, 87.15 -61.89, -30.48 in-in in 8.066 Saltbr-in 2.906 HRD-in -90.51, -54.07 69.36, 14.57 in-in-none SNCiin in-none ActLoopNT-in 2.798 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_iini APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -134.67 APE8-dihe-in -110.11, 125.22 APE8-rot-in 302.19 APE67-dihe-in -61.62, -37.34 -60.6, -34.55 APE12-dist-in 10.447 APE11-dist-in 12.341 APE10-dist-none 999.0 APE9-dist-in 3.806 None None SCS110 XRAY 1.75 0.167 0.204 A 310 295 1 0 0 1 [[44, 313]] 1.0 2cmw Homo sapiens CK1_CSNK1G1_HUMAN CK1 3.2e-116 393.3 2 261 260 186 187 188 190 192 73 87 91 161 163 162 164 233 221 216 215 214 213 212 211 210 119 Casein kinase I isoform gamma-1
CK1 CSNK1G2 KC1G2_HUMAN 2C47C P78368 46 337 415.0 5ID:61300 Type1 None DFGin 6.356 14.596 BLAminus DFGAsp-rot-in -130.46, 170.19 65.55, 88.27 199.65, -7.68 -102.77, 30.7 296.19, 90.63 -63.02, -30.33 in-none in 7.865 Saltbr-none 999.0 HRD-in -98.28, -49.29 66.18, 13.24 none-in-in SNCnii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.54, 145.79 APE9-dihe-na 130.26, 167.92 APE8-dihe-in -84.31, 112.7 APE8-rot-in 299.01 APE67-dihe-in -60.37, -38.22 -52.73, -35.19 APE12-dist-in 13.224 APE11-dist-in 12.469 APE10-dist-in 7.664 APE9-dist-in 5.033 None None CSD111 XRAY 2.4 0.211 0.257 C 313 283 9 0 0 0 [[46, 314]] 1.0 2c47 Homo sapiens CK1_CSNK1G2_HUMAN CK1 1.5e-117 397.6 1 261 261 187 188 189 191 193 75 89 93 162 164 163 165 234 222 217 216 215 214 213 212 211 120 Casein kinase I isoform gamma-2
CK1 TTBK1 TTBK1_HUMAN 4NFMA Q5TCY1 22 314 1321.0 No_ligand No_ligand None DFGin 5.273 12.877 BLAminus DFGAsp-rot-in -120.48, 172.2 50.57, 99.12 203.37, -22.97 -99.16, 15.76 304.55, 118.22 -58.69, -37.53 in-none in 7.29 Saltbr-none 999.0 HRD-in -72.88, -53.79 71.04, -1.8 none-in-in SNCnii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.78, 8.91 APE9-dihe-na -84.35, -161.43 APE8-dihe-in -79.51, 135.82 APE8-rot-in 299.35 APE67-dihe-in -48.61, -43.6 -70.15, -45.53 APE12-dist-in 11.801 APE11-dist-in 10.662 APE10-dist-in 7.491 APE9-dist-in 4.743 None None None XRAY 2.12 0.206 0.241 A 332 293 0 0 0 0 [[34, 295]] 1.0 4nfm Homo sapiens CK1_TTBK1_HUMAN CK1 5.5e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CK1 TTBK1 TTBK1_HUMAN 7JXYB Q5TCY1 20 312 1321.0 VSY:401 Type1.5_Back None DFGin 5.037 12.821 BLAminus DFGAsp-rot-in -128.48, 167.02 61.02, 73.97 205.29, -16.17 -81.31, 25.0 308.05, 139.51 -71.44, -25.56 in-in in 7.518 Saltbr-in 2.808 HRD-in -80.36, -54.74 76.29, -0.77 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_iini APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -77.25 APE8-dihe-in -84.51, 130.82 APE8-rot-in 316.52 APE67-dihe-in -60.95, -38.13 -60.87, -44.59 APE12-dist-in 11.627 APE11-dist-in 11.179 APE10-dist-none 999.0 APE9-dist-in 4.228 None None None XRAY 2.15 0.202 0.241 B 332 288 5 0 0 5 [[34, 295]] 1.0 7jxy Homo sapiens CK1_TTBK1_HUMAN CK1 5.5e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CMGC CDK2 CDK2_HUMAN 3EIDC P24941 1 296 298.0 No_ligand No_ligand None DFGin 6.489 15.863 BLAminus DFGAsp-rot-in -134.04, 176.12 56.38, 81.46 180.44, 9.14 -98.21, 27.52 280.67, 71.27 -62.82, -36.83 in-in in 8.955 Saltbr-in 2.698 HRD-in -81.37, -49.78 74.95, -21.85 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 125.0 APE8-dihe-in -62.75, 132.6 APE8-rot-in 299.6 APE67-dihe-in -57.24, -38.19 -61.24, -41.52 APE12-dist-in 13.922 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.564 None None None XRAY 3.15 0.207 0.261 C 298 290 6 0 0 2 [[4, 286]] 1.0 3eid Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3EIDA P24941 1 297 298.0 PO5:299 Type1 None DFGin 6.59 15.583 BLAminus DFGAsp-rot-in -132.85, -177.52 48.93, 84.46 181.58, 16.22 -100.76, 28.79 277.88, 66.9 -65.0, -34.5 in-in in 8.664 Saltbr-in 2.841 HRD-in -79.0, -48.15 75.16, -17.88 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -96.83 APE9-dihe-na -46.53, 147.39 APE8-dihe-in -64.52, 140.51 APE8-rot-in 326.76 APE67-dihe-in -65.78, -38.63 -57.31, -43.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.918 APE9-dist-in 4.475 None None None XRAY 3.15 0.207 0.261 A 298 292 5 0 0 2 [[4, 286]] 1.0 3eid Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9GOPA P24941 1 298 298.0 A1IOI:60301 Type1 None DFGin 7.359 15.214 BLAminus DFGAsp-rot-in -127.3, 173.02 54.03, 84.28 209.79, -4.1 -99.69, 32.25 282.59, 81.45 -70.11, -42.44 in-in in 8.723 Saltbr-in 2.939 HRD-in -74.49, -42.35 70.77, -14.6 in-in-none SNCiin in-none ActLoopNT-in 2.913 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.86 APE8-dihe-in -65.97, 133.38 APE8-rot-in 277.05 APE67-dihe-in -57.91, -32.79 -19.7, -52.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.633 None None None XRAY 2.158 0.232 0.271 A 298 291 7 0 0 7 [[4, 286]] 1.0 9gop Homo sapiens CMGC_CDK2_HUMAN CMGC 6.5e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDKL1 CDKL1_HUMAN 4AGUA Q00532 2 291 357.0 D15:500 Type1 None DFGin 6.926 15.225 BLAminus DFGAsp-rot-in -125.36, -173.19 61.0, 84.36 187.74, 30.96 -106.79, 0.32 274.19, 82.71 -54.94, -33.89 in-in in 8.329 Saltbr-in 2.668 HRD-in -62.63, -48.4 73.42, -8.74 in-in-none SNCiin in-none ActLoopNT-in 2.806 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.22 APE8-rot-in 301.17 APE67-dihe-in -58.09, -27.23 -56.92, -32.3 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T159D,Y161E None None XRAY 2.4 0.189 0.226 A 311 277 13 0 0 12 [[4, 287]] 1.0 4agu Homo sapiens CMGC_CDKL1_HUMAN CMGC 3e-80 275.7 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 1
CMGC CDKL1 CDKL1_HUMAN 4AGUB Q00532 3 292 357.0 D15:500 Type1 None DFGin 6.911 15.242 BLAminus DFGAsp-rot-in -123.13, -174.59 61.67, 77.11 206.36, 39.27 -99.83, 8.36 278.04, 80.77 -62.15, -31.07 in-in in 8.312 Saltbr-in 2.668 HRD-in -65.94, -47.41 70.79, -7.65 in-in-none SNCiin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.96 APE8-rot-in 300.0 APE67-dihe-in -56.83, -27.96 -64.83, -28.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T159D,Y161E None None XRAY 2.4 0.189 0.226 B 311 276 14 0 0 12 [[4, 287]] 1.0 4agu Homo sapiens CMGC_CDKL1_HUMAN CMGC 3e-80 275.7 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 1
CMGC CDKL1 CDKL1_HUMAN 4AGUC Q00532 2 291 357.0 D15:500 Type1 None DFGin 7.076 15.076 BLAminus DFGAsp-rot-in -126.2, -170.17 57.04, 81.0 185.68, 32.36 -105.59, 6.66 281.53, 85.88 -54.99, -37.13 in-in in 8.283 Saltbr-in 2.658 HRD-in -56.25, -49.02 74.36, -3.78 in-in-none SNCiin in-none ActLoopNT-in 2.791 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.06 APE8-rot-in 293.41 APE67-dihe-in -52.47, -36.63 -43.96, -43.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T159D,Y161E None None XRAY 2.4 0.189 0.226 C 311 278 12 0 0 12 [[4, 287]] 1.0 4agu Homo sapiens CMGC_CDKL1_HUMAN CMGC 3e-80 275.7 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase-like 1
CMGC CLK1 CLK1_HUMAN 6Q8PA P49759 148 482 484.0 HQB:60501 Type1 None DFGin 7.111 14.533 BLAminus DFGAsp-rot-in -124.47, -177.12 56.99, 94.11 192.42, 29.18 -115.67, 29.05 294.23, 87.9 -80.98, -10.13 in-in in 9.013 Saltbr-in 3.418 HRD-in -77.51, -42.79 69.43, -19.47 in-in-none SNCiin in-none ActLoopNT-in 3.131 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -135.51, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.79 APE8-rot-in 323.11 APE67-dihe-in -68.72, -18.82 -64.59, -40.03 APE12-dist-in 13.204 APE11-dist-in 11.201 APE10-dist-in 7.288 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 A 339 334 1 0 0 1 [[161, 477]] 1.0 6q8p Homo sapiens CMGC_CLK1_HUMAN CMGC 2.6e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC CLK1 CLK1_HUMAN 6Q8PC P49759 148 483 484.0 HQB:60501 Type1 None DFGin 7.261 13.945 BLAminus DFGAsp-rot-in -128.5, 178.53 59.41, 97.23 198.8, -47.44 -121.71, 37.79 304.27, 105.41 -86.72, -22.18 in-in in 8.676 Saltbr-in 3.006 HRD-in -68.24, -39.01 69.57, -23.21 in-in-none SNCiin in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aanii APEdist_iiin APE10-dihe-na -136.11, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.77 APE8-rot-in 314.52 APE67-dihe-in -61.24, -29.44 -57.39, -46.95 APE12-dist-in 13.763 APE11-dist-in 11.126 APE10-dist-in 7.295 APE9-dist-none 999.0 None None None XRAY 3.0 0.201 0.244 C 339 333 3 0 0 1 [[161, 477]] 1.0 6q8p Homo sapiens CMGC_CLK1_HUMAN CMGC 2.6e-93 318.5 1 301 301 324 325 326 328 330 191 206 210 285 287 286 288 361 349 344 343 342 341 340 339 338 242 Dual specificity protein kinase CLK1
CMGC DYRK1A DYR1A_HUMAN 6S11B Q13627 136 480 763.0 KQE:501 Type1 None DFGin 7.321 14.74 BLAminus DFGAsp-rot-in -122.66, 164.68 70.6, 90.6 194.98, -15.02 -105.94, 27.83 286.74, 77.35 -71.95, -23.72 in-in in 8.564 Saltbr-in 3.103 HRD-in -69.08, -43.23 70.93, 5.16 in-in-none SNCiin in-none ActLoopNT-in 2.871 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -126.36, 176.02 APE9-dihe-na 69.06, 141.8 APE8-dihe-in -64.1, 141.34 APE8-rot-in 291.06 APE67-dihe-in -52.52, -31.33 -58.27, -46.65 APE12-dist-none 999.0 APE11-dist-in 11.465 APE10-dist-in 7.262 APE9-dist-in 3.159 None PTR321 PTR321 XRAY 2.445 0.173 0.21 B 361 330 15 0 0 3 [[159, 479]] 1.0 6s11 Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.7e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7Z5NH Q13627 135 480 763.0 3NG:501 Type1 None DFGin 6.679 14.847 BLAminus DFGAsp-rot-in -128.66, -179.58 53.82, 77.25 203.79, -10.14 -93.05, 20.83 280.85, 75.88 -63.97, -13.6 in-in in 9.075 Saltbr-in 3.001 HRD-in -63.15, -47.83 74.92, 6.9 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none nonTYR APEdihe_aaini APEdist_niii APE10-dihe-na -156.21, 166.85 APE9-dihe-na 64.29, 161.67 APE8-dihe-in -89.72, 140.84 APE8-rot-none 999.0 APE67-dihe-in -54.39, -32.97 -48.02, -56.25 APE12-dist-none 999.0 APE11-dist-in 10.614 APE10-dist-in 7.767 APE9-dist-in 3.208 None PTR321 PTR321 XRAY 2.77 0.207 0.252 H 370 307 39 0 0 4 [[159, 479]] 1.0 7z5n Homo sapiens CMGC_DYRK1A_HUMAN CMGC 9.5e-91 310.1 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 4DITA P49841 35 387 420.0 0KD:501 Type1 None DFGin 6.805 13.948 BLAminus DFGAsp-rot-in -145.37, 179.76 65.92, 81.37 185.26, 44.88 -105.97, 22.54 288.96, 82.14 -68.29, -17.95 in-in in 8.825 Saltbr-in 2.717 HRD-in -69.87, -50.6 73.87, 5.2 in-in-none SNCiin in-none ActLoopNT-in 2.939 ActLoopCT-none nonTYR APEdihe_aannn APEdist_iinn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 14.5 999.0, 999.0 APE12-dist-in 13.489 APE11-dist-in 10.385 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR216 PTR216 XRAY 2.6 0.243 0.304 A 382 329 24 0 0 4 [[56, 340]] 1.0 4dit Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.3 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4FV4A P28482 9 357 360.0 EK7:60401 Type1 None DFGin 6.926 15.489 BLAminus DFGAsp-rot-in -127.76, 178.3 63.88, 86.85 205.38, -23.99 -108.47, 28.84 281.36, 73.37 -69.43, -40.09 in-in in 9.642 Saltbr-in 2.648 HRD-in -75.2, -46.77 73.02, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.837 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -41.0 APE9-dihe-na -73.39, 169.26 APE8-dihe-in -71.16, 102.82 APE8-rot-in 309.16 APE67-dihe-in -58.85, -32.49 -29.11, -51.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.377 APE9-dist-in 4.371 None None CME161 XRAY 2.5 0.219 0.253 A 360 330 19 0 0 12 [[25, 313]] 1.0 4fv4 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV5A P28482 9 357 360.0 EK9:60401 Type1 None DFGin 6.911 15.436 BLAminus DFGAsp-rot-in -125.94, 174.49 65.85, 87.03 191.9, -3.89 -106.87, 28.63 280.66, 75.44 -65.59, -45.85 in-in in 9.354 Saltbr-in 2.71 HRD-in -72.18, -50.7 73.7, -7.14 in-in-none SNCiin in-none ActLoopNT-in 2.767 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 177.89 APE8-dihe-in -70.68, 121.16 APE8-rot-in 311.58 APE67-dihe-in -59.32, -29.75 -54.36, -44.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.642 None None CME161 XRAY 2.4 0.206 0.248 A 360 331 18 0 0 14 [[25, 313]] 1.0 4fv5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV6A P28482 9 357 360.0 E57:60401 Type1 None DFGin 6.952 14.813 BLAminus DFGAsp-rot-in -126.85, -179.36 58.14, 87.74 187.91, 14.77 -105.16, 32.96 280.54, 72.76 -66.83, -48.49 in-in in 9.119 Saltbr-in 2.728 HRD-in -73.71, -49.52 71.01, 1.58 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 164.79 APE8-dihe-in -71.11, 129.52 APE8-rot-in 305.06 APE67-dihe-in -62.14, -26.42 -57.08, -45.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.348 None None None XRAY 2.5 0.222 0.249 A 360 332 17 0 0 14 [[25, 313]] 1.0 4fv6 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV8A P28482 8 357 360.0 E63:60401 Type1 None DFGin 7.006 15.497 BLAminus DFGAsp-rot-in -127.0, -178.27 61.48, 83.09 215.8, -43.43 -106.04, 21.77 282.14, 67.68 -61.35, -37.24 in-in in 9.531 Saltbr-in 2.852 HRD-in -71.05, -46.98 70.21, -0.53 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -57.07 APE9-dihe-na -109.25, -165.95 APE8-dihe-in -76.52, 120.67 APE8-rot-in 315.06 APE67-dihe-in -62.49, -24.63 -55.08, -35.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.536 APE9-dist-in 4.721 None None CME161 XRAY 2.0 0.188 0.227 A 360 334 16 0 0 13 [[25, 313]] 1.0 4fv8 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FV9A P28482 8 357 360.0 E71:60401 Type1 None DFGin 6.928 15.636 BLAminus DFGAsp-rot-in -132.32, -178.13 60.98, 82.89 199.61, -17.9 -105.46, 23.11 283.0, 73.52 -62.53, -38.05 in-in in 9.598 Saltbr-in 3.038 HRD-in -72.61, -49.16 72.56, -1.28 in-in-none SNCiin in-none ActLoopNT-in 2.743 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 179.68 APE8-dihe-in -79.93, 120.69 APE8-rot-in 307.61 APE67-dihe-in -59.23, -20.77 -43.94, -53.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.569 None None CME161 XRAY 2.11 0.201 0.238 A 360 332 18 0 0 14 [[25, 313]] 1.0 4fv9 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.4e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BUEA P28482 11 358 360.0 4V8:60401 Type1 None DFGin 6.9 15.224 BLAminus DFGAsp-rot-in -122.39, -177.08 63.38, 82.69 187.93, 6.91 -105.24, 21.84 282.5, 70.9 -61.62, -35.58 in-in in 9.256 Saltbr-in 2.813 HRD-in -71.44, -49.4 73.74, -0.74 in-in-none SNCiin in-none ActLoopNT-in 2.793 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.04 APE8-rot-in 329.09 APE67-dihe-in -60.95, -23.57 -107.06, -4.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.185 0.23 A 361 329 19 0 0 15 [[25, 313]] 1.0 5bue Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BUIA P28482 11 358 360.0 4V9:60402 Type1 None DFGin 6.991 15.3 BLAminus DFGAsp-rot-in -130.19, 179.53 65.05, 80.02 197.0, -9.11 -99.3, 20.21 283.96, 66.32 -59.55, -33.7 in-in in 9.549 Saltbr-in 2.722 HRD-in -68.56, -51.77 75.84, -7.59 in-in-none SNCiin in-none ActLoopNT-in 2.846 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -130.01 APE8-rot-in 334.62 APE67-dihe-in -56.78, -27.08 -106.13, -3.49 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.12 0.172 0.222 A 361 338 10 0 0 10 [[25, 313]] 1.0 5bui Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BUJA P28482 9 358 360.0 4VB:60401 Type1 None DFGin 6.999 15.405 BLAminus DFGAsp-rot-in -125.43, -179.58 67.11, 82.68 208.93, -35.9 -104.4, 22.22 283.46, 67.98 -61.34, -32.84 in-in in 9.526 Saltbr-in 2.694 HRD-in -77.84, -46.67 74.74, -8.15 in-in-none SNCiin in-none ActLoopNT-in 2.787 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.23 APE8-rot-in 314.32 APE67-dihe-in -58.67, -24.13 -104.72, -0.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.85 0.173 0.206 A 361 331 19 0 0 15 [[25, 313]] 1.0 5buj Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BVDA P28482 9 358 360.0 4VF:60401 Type1 None DFGin 7.012 14.82 BLAminus DFGAsp-rot-in -120.88, -174.96 58.49, 83.25 189.57, 7.38 -99.87, 23.43 283.53, 71.8 -56.85, -34.73 in-in in 9.264 Saltbr-in 2.627 HRD-in -80.64, -49.81 78.16, -6.37 in-in-none SNCiin in-none ActLoopNT-in 2.72 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.19 APE8-rot-in 306.38 APE67-dihe-in -62.44, -24.22 -51.26, -49.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.172 0.207 A 361 330 20 0 0 16 [[25, 313]] 1.0 5bvd Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BVEA P28482 9 358 360.0 4VG:60401 Type1 None DFGin 6.995 14.775 BLAminus DFGAsp-rot-in -125.12, -174.29 54.55, 82.42 191.52, 7.85 -96.55, 21.3 282.29, 70.85 -61.67, -24.38 in-in in 9.139 Saltbr-in 2.729 HRD-in -80.4, -49.72 75.16, -2.3 in-in-none SNCiin in-none ActLoopNT-in 2.781 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.36 APE8-rot-in 307.25 APE67-dihe-in -61.28, -26.45 -50.74, -47.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.175 0.22 A 361 330 20 0 0 16 [[25, 313]] 1.0 5bve Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 5BVFA P28482 9 358 360.0 4VJ:60401 Type1 None DFGin 6.801 14.714 BLAminus DFGAsp-rot-in -123.98, -172.37 55.64, 78.56 188.66, 15.06 -97.05, 25.41 283.39, 68.26 -60.16, -26.7 in-in in 9.262 Saltbr-in 2.69 HRD-in -79.7, -47.41 71.71, 1.48 in-in-none SNCiin in-none ActLoopNT-in 2.691 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.62, -24.81 999.0, -48.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.183 0.221 A 361 327 23 0 0 17 [[25, 313]] 1.0 5bvf Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3I5ZA P28482 8 357 360.0 Z48:60401 Type1 None DFGin 6.917 15.249 BLAminus DFGAsp-rot-in -127.32, 174.22 70.2, 66.73 192.31, -4.91 -83.95, 23.54 288.3, 68.12 -65.3, -33.09 in-in in 9.313 Saltbr-in 2.715 HRD-in -75.44, -48.03 71.03, -6.74 in-in-none SNCiin in-none ActLoopNT-in 2.717 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -13.55 APE9-dihe-na -121.16, 175.77 APE8-dihe-in -61.26, 116.09 APE8-rot-in 314.5 APE67-dihe-in -57.72, -29.32 -61.25, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.812 APE9-dist-in 4.954 None None None XRAY 2.2 0.217 0.258 A 380 331 19 0 0 14 [[25, 313]] 1.0 3i5z Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.1e-85 293.5 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3I60A P28482 8 358 360.0 E86:60401 Type1 None DFGin 6.968 15.153 BLAminus DFGAsp-rot-in -121.98, 176.49 63.3, 79.85 194.72, -9.39 -98.81, 21.48 280.47, 70.03 -59.78, -40.19 in-in in 9.289 Saltbr-in 3.111 HRD-in -73.88, -46.85 79.23, -3.42 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.19 APE8-dihe-in -93.47, 121.54 APE8-rot-in 308.65 APE67-dihe-in -68.68, -19.01 -43.75, -44.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.496 None None None XRAY 2.5 0.211 0.248 A 380 335 16 0 0 13 [[25, 313]] 1.0 3i60 Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.1e-85 293.5 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPIA P28482 10 356 360.0 N0V:60401 Type1.5_Front None DFGin 6.816 16.494 BLAminus DFGAsp-rot-in -135.48, 169.13 71.03, 93.69 199.93, -40.15 -111.04, 34.22 293.24, 78.08 -67.49, -29.15 in-in in 9.892 Saltbr-in 3.054 HRD-in -72.72, -50.31 76.41, -2.79 in-in-none SNCiin in-none ActLoopNT-in 2.808 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.69 APE8-rot-in 306.85 APE67-dihe-in -62.81, -15.96 -67.99, -45.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None TPO185,PTR187 TPO185,PTR187 XRAY 3.0 0.189 0.26 A 354 326 17 0 0 12 [[25, 313]] 1.0 6opi Homo sapiens CMGC_MAPK1_HUMAN CMGC 8.9e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.87 13.865 BLAminus DFGAsp-rot-in -125.0, 176.56 71.88, 86.33 191.14, -10.66 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.793 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361 312 42 0 0 20 [[58, 569]] 1.0 4f99 Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.759 13.936 BLAminus DFGAsp-rot-in -128.61, 175.54 70.41, 87.99 191.32, -8.92 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.757 Saltbr-in 3.408 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361 315 41 0 0 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.913 14.207 BLAminus DFGAsp-rot-in -118.89, -178.58 68.69, 81.33 193.06, -3.59 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.846 Saltbr-in 2.634 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.643 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361 317 41 0 0 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.888 14.044 BLAminus DFGAsp-rot-in -126.02, 169.07 75.11, 84.03 194.62, -1.51 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.937 Saltbr-in 2.775 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.714 None None None XRAY 1.67 0.158 0.185 A 358 345 5 0 0 5 [[58, 569]] 1.0 6ya7 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus DFGAsp-rot-in -118.93, 173.08 76.34, 83.66 188.96, -2.47 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BA O00311 39 572 574.0 0SY:601 Type1 None DFGin 5.763 14.014 BLAminus DFGAsp-rot-in -127.87, 167.58 73.15, 98.39 210.16, -36.47 -107.19, 18.49 295.91, 97.29 -66.44, -7.97 in-in in 9.088 Saltbr-in 2.963 HRD-in -56.22, -51.45 80.31, -5.48 in-in-none SNCiin in-none ActLoopNT-in 2.827 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -71.45, 117.57 APE8-rot-in 316.95 APE67-dihe-in -71.7, -9.89 -46.76, -40.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 A 361 318 38 0 0 17 [[58, 569]] 1.0 4f9b Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9BC O00311 37 572 574.0 0SY:601 Type1 None DFGin 5.596 14.137 BLAminus DFGAsp-rot-in -121.21, 173.13 67.81, 82.77 213.16, -38.5 -85.78, 14.03 293.34, 97.94 -53.73, -27.05 in-in in 8.886 Saltbr-in 2.749 HRD-in -63.82, -49.28 75.73, -3.37 in-in-none SNCiin in-none ActLoopNT-in 2.786 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -74.89, 119.22 APE8-rot-in 309.91 APE67-dihe-in -59.77, -15.79 -42.06, -45.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.19 0.239 C 361 316 42 0 0 21 [[58, 569]] 1.0 4f9b Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9CA O00311 41 572 574.0 0SX:601 Type1 None DFGin 5.868 14.2 BLAminus DFGAsp-rot-in -130.13, 163.69 79.42, 87.08 198.91, -9.59 -94.29, 18.63 289.91, 100.22 -72.97, -7.76 in-in in 8.945 Saltbr-in 2.697 HRD-in -63.65, -50.25 73.79, -1.33 in-in-none SNCiin in-none ActLoopNT-in 2.78 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -72.81, 123.96 APE8-rot-in 305.35 APE67-dihe-in -59.52, -17.81 -47.91, -44.67 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.08 0.206 0.249 A 361 306 48 0 0 26 [[58, 569]] 1.0 4f9c Homo sapiens OTHER_CDC7_HUMAN CMGC 2.1e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA6A O00311 38 573 574.0 0SX:60601,BO3:60604 Type1,Type1 None DFGin 5.683 14.123 BLAminus DFGAsp-rot-in -124.62, 164.87 81.15, 86.75 201.51, -13.15 -92.84, 17.97 293.82, 101.75 -74.2, -7.34 in-in in 8.984 Saltbr-in 2.653 HRD-in -67.91, -46.07 79.98, -17.89 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 166.27, -149.55 APE8-dihe-in -136.79, 136.61 APE8-rot-in 295.13 APE67-dihe-inflip 96.71, -11.03 -52.89, 131.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.586 None None None XRAY 1.44 0.168 0.193 A 359 340 12 0 0 12 [[58, 569]] 1.0 6ya6 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER ERN1 ERN1_HUMAN 4YZCA O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.54 13.598 BLAminus DFGAsp-rot-in -149.66, -173.45 57.49, 66.53 201.33, -9.38 -77.65, -2.16 287.89, 65.87 -48.01, -38.7 in-none in 9.363 Saltbr-none 999.0 HRD-in -69.99, -44.37 70.23, -12.54 none-in-in SNCnii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -68.95, 160.8 APE9-dihe-na 106.7, 168.85 APE8-dihe-in -105.56, 142.33 APE8-rot-in 309.63 APE67-dihe-inflip 90.78, -21.58 -55.3, 131.97 APE12-dist-in 10.401 APE11-dist-in 11.328 APE10-dist-in 5.406 APE9-dist-in 3.601 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 A 405 385 17 0 0 1 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZCB O75460 562 963 977.0 STU:1001 Type1 None DFGin 4.362 13.613 BLAminus DFGAsp-rot-in -140.88, -173.22 59.3, 72.64 207.2, -16.91 -84.99, 5.45 286.37, 62.28 -53.44, -38.69 in-none in 9.608 Saltbr-none 999.0 HRD-in -70.83, -44.64 74.46, -16.49 none-in-in SNCnii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.48, 164.52 APE9-dihe-na 106.87, 177.31 APE8-dihe-in -111.04, 139.81 APE8-rot-in 310.36 APE67-dihe-inflip 90.66, -20.76 -52.98, 131.15 APE12-dist-in 10.836 APE11-dist-in 11.233 APE10-dist-in 5.394 APE9-dist-in 3.693 None SEP724,SEP726,SEP729 SEP724,SEP726,SEP729 XRAY 2.494 0.249 0.289 B 405 384 18 0 0 2 [[571, 832]] 1.0 4yzc Homo sapiens OTHER_ERN1_HUMAN CAMK 2.9e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 6W3KA O75460 562 963 977.0 SJS:1001 Type1 None DFGin 5.733 14.486 BLAminus DFGAsp-rot-in -136.61, -178.37 67.07, 78.89 204.21, -11.93 -100.93, 17.07 281.07, 41.19 -67.11, -27.01 in-in in 8.204 Saltbr-in 2.756 HRD-in -74.42, -52.27 75.94, 0.0 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 69.85 APE9-dihe-na 125.22, -177.52 APE8-dihe-in -111.61, 120.85 APE8-rot-in 306.38 APE67-dihe-inflip 105.25, -16.79 -50.22, 133.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.729 APE9-dist-in 3.977 None None None XRAY 2.08 0.192 0.217 A 434 398 4 0 0 4 [[571, 832]] 1.0 6w3k Homo sapiens OTHER_ERN1_HUMAN CAMK 3.5e-35 127.8 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER GAK GAK_HUMAN 4Y8DA O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.562 13.518 BLAminus DFGAsp-rot-in -138.4, -164.21 74.62, 66.04 199.54, -60.61 -93.04, 16.88 304.79, 110.01 -68.29, -18.06 in-in in 8.973 Saltbr-in 2.822 HRD-in -78.84, -52.81 74.15, 0.63 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 A 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4Y8DB O14976 27 333 1311.0 49J:401 Type1 None DFGin 5.558 13.438 BLAminus DFGAsp-rot-in -140.66, -164.98 74.22, 67.3 200.82, -62.27 -94.1, 19.71 305.39, 110.44 -72.07, -18.1 in-in in 8.927 Saltbr-in 2.81 HRD-in -76.85, -53.12 74.48, -1.34 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.194 0.232 B 340 262 45 0 0 28 [[40, 313]] 1.0 4y8d Homo sapiens OTHER_GAK_HUMAN CAMK 5.5e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER ULK2 ULK2_HUMAN 6QAUB Q8IYT8 1 274 1036.0 1FV:60301 Type1 None DFGin 6.69 14.941 BLAminus DFGAsp-rot-in -136.25, 168.35 65.98, 84.31 191.46, -2.27 -99.13, 17.87 284.11, 83.42 -56.69, -27.27 in-in in 9.16 Saltbr-in 2.803 HRD-in -82.01, -52.27 83.93, -11.12 in-in-none SNCiin in-none ActLoopNT-in 3.005 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -75.13, -14.46 999.0, 14.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.48 0.198 0.237 B 280 264 10 0 0 10 [[7, 271]] 1.0 6qau Homo sapiens OTHER_ULK2_HUMAN ULK 6.5e-132 444.6 1 256 256 157 158 159 161 163 39 56 60 128 130 129 131 196 184 179 178 177 176 175 174 173 86 Serine/threonine-protein kinase ULK2
OTHER WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.965 14.31 BLAminus DFGAsp-rot-in -123.5, -167.41 55.36, 79.67 189.86, 15.66 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 na-na na 15.412 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.014 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279 260 14 0 0 9 [[220, 479]] 1.0 5wdy Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
STE MAP2K7 MP2K7_HUMAN 5Z1DA O14733 103 403 419.0 95U:60501 Type1 None DFGin 5.857 14.585 BLAminus DFGAsp-rot-in -132.64, 165.55 65.51, 87.28 188.49, -3.46 -111.34, 26.51 319.06, 84.39 -58.48, -30.36 na-na na 8.357 Saltbr-na 4.043 HRD-in -83.1, -42.1 68.08, 4.78 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiai APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.65 APE8-dihe-in -8.48, 107.0 APE8-rot-na 193.18 APE67-dihe-in -53.9, -37.87 -45.41, -42.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.998 None None None XRAY 2.28 0.195 0.258 A 324 274 27 0 0 13 [[120, 380]] 1.0 5z1d Homo sapiens STE_MAP2K7_HUMAN STE 1e-79 273.6 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.195 14.549 BLAminus DFGAsp-rot-in -146.55, 178.23 54.3, 83.97 192.46, -3.23 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 na-na na 8.345 Saltbr-na 3.36 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307 265 33 0 0 19 [[120, 380]] 1.0 6yg3 Homo sapiens STE_MAP2K7_HUMAN STE 2.5e-80 275.5 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP3K14 M3K14_HUMAN 4G3DD Q99558 338 657 947.0 No_ligand No_ligand None DFGin 5.247 13.197 BLAminus DFGAsp-rot-in -139.97, -172.27 56.52, 77.31 194.92, -10.61 -95.91, 22.53 297.92, 87.23 -51.62, -29.6 in-in in 8.447 Saltbr-in 3.513 HRD-in -79.01, -53.56 97.41, -27.23 in-in-none SNCiin in-none ActLoopNT-in 2.89 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 88.51 APE9-dihe-na -78.1, -164.4 APE8-dihe-in -58.77, 132.43 APE8-rot-in 301.85 APE67-dihe-in -63.25, -43.05 -56.52, -49.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.409 APE9-dist-in 3.602 None None None XRAY 2.9 0.206 0.266 D 371 290 17 0 0 13 [[399, 652]] 1.0 4g3d Homo sapiens STE_MAP3K14_HUMAN STE 1.4e-62 217.5 4 252 249 533 534 535 537 539 429 440 444 512 514 513 515 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4G3DE Q99558 332 663 947.0 No_ligand No_ligand None DFGin 5.283 12.998 BLAminus DFGAsp-rot-in -137.41, -171.56 53.74, 79.67 199.21, -15.84 -98.49, 16.37 295.95, 82.21 -51.27, -29.34 in-in in 8.088 Saltbr-in 3.275 HRD-in -56.22, -43.54 79.99, -16.43 in-in-none SNCiin in-none ActLoopNT-in 3.058 ActLoopCT-none nonTYR APEdihe_aanin APEdist_nnii APE10-dihe-na 999.0, 175.31 APE9-dihe-na -160.21, -138.78 APE8-dihe-none -77.0, 999.0 APE8-rot-in 301.74 APE67-dihe-none 999.0, -37.88 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.602 APE9-dist-in 4.079 None None None XRAY 2.9 0.206 0.266 E 371 283 36 0 0 15 [[399, 652]] 1.0 4g3d Homo sapiens STE_MAP3K14_HUMAN STE 1.4e-62 217.5 4 252 249 533 534 535 537 539 429 440 444 512 514 513 515 578 566 561 560 559 558 557 556 555 470 Mitogen-activated protein kinase kinase kinase 14
STE MAP3K5 M3K5_HUMAN 6OYTA Q99683 667 939 1374.0 NJV:61001 Type1 None DFGin 5.681 13.351 BLAminus DFGAsp-rot-in -125.18, 173.88 59.78, 86.22 201.94, -12.35 -94.31, 25.78 300.06, 101.7 -62.97, -32.35 in-in in 8.832 Saltbr-in 2.26 HRD-in -73.98, -49.46 76.75, 0.8 in-in-none SNCiin in-none ActLoopNT-in 2.979 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 A 280 221 52 0 0 20 [[678, 938]] 1.0 6oyt Homo sapiens STE_MAP3K5_HUMAN STE 5.2e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTC Q99683 671 938 1374.0 NJV:61001 Type1 None DFGin 6.079 13.489 BLAminus DFGAsp-rot-in -119.54, 172.14 56.5, 86.88 205.51, -12.35 -93.47, 25.36 302.99, 99.79 -64.69, -32.12 in-in in 8.321 Saltbr-in 2.529 HRD-in -71.89, -48.46 74.08, 0.71 in-in-none SNCiin in-none ActLoopNT-in 3.275 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.69, -21.53 999.0, -119.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.824 0.235 0.29 C 280 236 32 0 0 13 [[678, 938]] 1.0 6oyt Homo sapiens STE_MAP3K5_HUMAN STE 5.2e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6OYTD Q99683 667 939 1374.0 NJV:61002 Type1 None DFGin 5.873 13.601 BLAminus DFGAsp-rot-in -124.35, 174.62 60.77, 86.25 201.7, -14.23 -96.47, 25.37 301.41, 82.49 -61.64, -30.64 in-in in 9.067 Saltbr-in 2.509 HRD-in -72.35, -49.7 75.51, 0.65 in-in-none SNCiin in-none ActLoopNT-in 2.818 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -134.49 APE8-dihe-in -107.42, 132.24 APE8-rot-in 319.21 APE67-dihe-in -73.68, -28.35 -46.85, -37.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.788 None None None XRAY 2.824 0.235 0.29 D 280 250 23 0 0 10 [[678, 938]] 1.0 6oyt Homo sapiens STE_MAP3K5_HUMAN STE 5.2e-81 277.8 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 5UP3B Q99683 671 939 1374.0 8GS:1000 Type1 None DFGin 6.404 13.522 BLAminus DFGAsp-rot-in -145.21, 155.75 74.64, 95.67 202.94, -9.78 -108.04, 14.34 302.59, 105.08 -64.34, -17.97 in-in in 8.566 Saltbr-in 2.91 HRD-in -87.24, -40.99 75.36, -9.84 in-in-none SNCiin in-none ActLoopNT-in 3.023 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.91 APE8-dihe-in -57.21, 126.4 APE8-rot-in 314.64 APE67-dihe-in -121.68, -3.36 -59.97, -11.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.493 None None None XRAY 2.95 0.244 0.289 B 271 243 26 0 0 11 [[678, 938]] 1.0 5up3 Homo sapiens STE_MAP3K5_HUMAN STE 4.6e-81 278.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 6E2NB Q99683 670 939 1374.0 KK8:1001 Type1 None DFGin 6.543 13.925 BLAminus DFGAsp-rot-in -124.43, -172.06 45.44, 94.03 201.32, -28.65 -100.49, 19.41 297.14, 84.65 -62.68, -39.36 in-in in 8.526 Saltbr-in 2.317 HRD-in -77.48, -52.13 80.81, -2.87 in-in-none SNCiin in-none ActLoopNT-in 3.176 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -34.96 APE9-dihe-na 147.14, -170.88 APE8-dihe-in -105.95, 128.57 APE8-rot-in 300.89 APE67-dihe-in -77.71, -0.68 -49.6, -53.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.857 APE9-dist-in 3.588 None TPO838 TPO838 XRAY 2.098 0.217 0.257 B 295 250 20 0 0 10 [[678, 938]] 1.0 6e2n Homo sapiens STE_MAP3K5_HUMAN STE 6.3e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 7MU6B Q99683 671 940 1374.0 A1AWT:1001 Type1 None DFGin 6.472 13.842 BLAminus DFGAsp-rot-in -137.24, 175.06 55.73, 97.84 197.32, -22.26 -102.69, 23.8 295.93, 95.1 -68.36, -28.7 in-in in 8.476 Saltbr-in 2.441 HRD-in -80.7, -46.25 77.78, 2.33 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 66.13 APE9-dihe-na -85.74, -166.57 APE8-dihe-in -87.23, 138.03 APE8-rot-in 306.07 APE67-dihe-in -71.64, -12.66 -62.6, -45.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.317 APE9-dist-in 3.356 None None None XRAY 2.165 0.191 0.214 B 334 261 9 0 0 9 [[678, 938]] 1.0 7mu6 Homo sapiens STE_MAP3K5_HUMAN STE 1.9e-80 276.0 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 6NFZA Q92918 7 292 833.0 B49:401 Type1 None DFGin 6.284 14.02 BLAminus DFGAsp-rot-in -132.74, -179.97 58.53, 80.12 190.95, 31.78 -96.32, 31.7 293.92, 71.67 -62.29, -28.15 in-none in 8.634 Saltbr-none 999.0 HRD-in -77.39, -48.16 72.34, -9.45 none-in-in SNCnii in-in ActLoopNT-in 2.838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.28, 161.74 APE9-dihe-na 145.04, -157.57 APE8-dihe-in -127.09, 102.67 APE8-rot-in 298.6 APE67-dihe-in -54.23, -29.76 -34.34, -51.63 APE12-dist-in 8.241 APE11-dist-in 11.626 APE10-dist-in 6.178 APE9-dist-in 3.916 None TPO165,SEP171 TPO165,SEP171 XRAY 2.966 0.209 0.251 A 309 270 16 0 0 0 [[17, 274]] 1.0 6nfz Homo sapiens STE_MAP4K1_HUMAN STE 1.8e-92 315.3 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE PAK1 PAK1_HUMAN 4DAWA Q13153 249 542 545.0 0H2:601 Type1 None DFGin 6.003 15.555 BLAminus DFGAsp-rot-in -145.17, -172.18 68.39, 87.65 203.02, -20.16 -98.45, 24.44 292.06, 86.63 -67.73, -11.03 in-none in 9.893 Saltbr-none 999.0 HRD-in -68.43, -51.96 75.51, -0.37 none-in-in SNCnii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.04, -25.02 APE9-dihe-na -71.13, 167.89 APE8-dihe-in -72.39, 123.36 APE8-rot-in 310.01 APE67-dihe-in -62.64, -23.02 -43.95, -50.55 APE12-dist-in 8.844 APE11-dist-in 10.963 APE10-dist-in 4.954 APE9-dist-in 3.225 K299R TPO423 TPO423 XRAY 2.0 0.203 0.238 A 297 294 0 0 0 0 [[270, 521]] 1.0 4daw Homo sapiens STE_PAK1_HUMAN STE 7.5e-95 323.1 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK1 PAK1_HUMAN 2HY81 Q13153 249 541 545.0 1ST:201 Type1 None DFGin 6.311 15.646 BLAminus DFGAsp-rot-in -141.81, -175.39 62.15, 82.56 195.53, -11.86 -97.27, 31.86 287.16, 72.33 -72.78, -7.5 in-none in 9.972 Saltbr-none 999.0 HRD-in -69.86, -49.3 75.07, -4.86 none-in-in SNCnii in-in ActLoopNT-in 2.806 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.75, -18.53 APE9-dihe-na -69.92, -171.39 APE8-dihe-in -100.69, 123.46 APE8-rot-in 301.63 APE67-dihe-in -57.72, -21.79 -25.33, -67.16 APE12-dist-in 8.906 APE11-dist-in 11.053 APE10-dist-in 5.133 APE9-dist-in 3.348 K299R,T423E None None XRAY 2.0 0.208 0.234 1 297 293 0 0 0 0 [[270, 521]] 1.0 2hy8 Homo sapiens STE_PAK1_HUMAN STE 3.1e-94 321.1 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE STK4 STK4_HUMAN 6YATB Q13043 29 307 487.0 OJ5:401 Type1 None DFGin 6.466 13.854 BLAminus DFGAsp-rot-in -122.05, 162.57 77.71, 80.56 202.03, -18.93 -97.31, 25.12 292.31, 85.07 -58.76, -37.95 in-none in 8.684 Saltbr-none 999.0 HRD-in -73.27, -56.52 82.91, -0.91 none-in-in SNCnii in-in ActLoopNT-in 2.751 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.95, 157.18 APE9-dihe-na 132.69, -166.17 APE8-dihe-in -108.9, 116.74 APE8-rot-in 312.41 APE67-dihe-in -55.33, -29.29 -39.0, -55.77 APE12-dist-in 8.432 APE11-dist-in 11.492 APE10-dist-in 5.789 APE9-dist-in 3.286 None TPO177,TPO183 TPO177,TPO183 XRAY 2.58 0.227 0.259 B 314 276 3 0 0 0 [[30, 281]] 1.0 6yat Homo sapiens STE_STK4_HUMAN STE 4.4e-102 346.9 2 257 256 166 167 168 170 172 59 73 77 146 148 147 149 206 194 189 188 187 186 185 184 183 103 Serine/threonine-protein kinase 4
STE TNIK TNIK_HUMAN 6RA5B Q9UKE5 14 310 1360.0 No_ligand No_ligand None DFGin 5.788 14.265 BLAminus DFGAsp-rot-in -136.76, 172.1 63.28, 95.48 196.41, 51.45 -100.13, 6.47 275.29, 87.87 -57.63, -20.13 in-none in 8.566 Saltbr-none 999.0 HRD-in -68.06, -48.15 74.67, 0.64 none-in-in SNCnii in-in ActLoopNT-in 2.799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.41, 141.46 APE9-dihe-na 147.76, -160.31 APE8-dihe-in -111.74, 117.5 APE8-rot-in 316.28 APE67-dihe-in -47.73, -42.39 -30.97, -64.12 APE12-dist-in 8.838 APE11-dist-in 11.283 APE10-dist-in 5.559 APE9-dist-in 3.461 None TPO181,TPO187 TPO181,TPO187 XRAY 2.9 999.0 999.0 B 306 283 14 0 0 7 [[25, 289]] 1.0 6ra5 Homo sapiens STE_TNIK_HUMAN STE 3.1e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 2X7FD Q9UKE5 17 306 1360.0 824:500 Type1 None DFGin 6.647 15.046 BLAminus DFGAsp-rot-in -124.52, 178.85 56.71, 102.04 191.82, 48.12 -114.11, 22.87 287.2, 83.98 -65.42, -48.91 in-none in 9.444 Saltbr-none 999.0 HRD-in -66.67, -40.26 66.21, -2.06 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 119.49 APE8-rot-none 999.0 APE67-dihe-in -52.92, -32.7 -93.58, 2.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.21 0.229 D 326 236 51 0 0 15 [[25, 289]] 1.0 2x7f Homo sapiens STE_TNIK_HUMAN STE 3.8e-105 356.8 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 8R7GC Q04771 206 498 509.0 YEE:501 Type1 None DFGin 7.86 12.623 BLAminus DFGAsp-rot-in -132.3, 171.44 65.89, 83.48 198.87, -13.1 -96.38, 20.1 305.34, 173.35 -63.32, -22.24 in-in in 8.155 Saltbr-in 3.027 HRD-in -79.84, -56.85 80.44, 0.82 in-in-none SNCiin in-none ActLoopNT-in 2.792 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -50.52 APE9-dihe-na -69.1, 173.0 APE8-dihe-in -60.22, 124.79 APE8-rot-in 310.22 APE67-dihe-in -65.34, -27.73 -64.05, -29.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.082 APE9-dist-in 3.578 Q207D None None XRAY 2.09 0.228 0.253 C 301 280 13 0 0 12 [[207, 497]] 1.0 8r7g Homo sapiens TKL_ACVR1_HUMAN TKL 2e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BMPR2 BMPR2_HUMAN 6UNPA Q13873 199 509 1038.0 ADP:601,ADP:602 ATPlike,Allosteric None DFGin 7.015 14.066 BLAminus DFGAsp-rot-in -140.5, 177.86 62.51, 75.21 192.46, -3.44 -94.82, 26.77 301.08, 104.11 -62.66, -20.97 in-in in 7.983 Saltbr-in 2.832 HRD-in -73.31, -49.03 80.8, -8.07 in-in-none SNCiin in-none ActLoopNT-in 2.92 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -134.35, -10.44 APE9-dihe-na -70.57, -158.87 APE8-dihe-in -91.29, 127.64 APE8-rot-in 299.54 APE67-dihe-in -49.77, -33.71 -61.84, -45.11 APE12-dist-none 999.0 APE11-dist-in 12.741 APE10-dist-in 7.284 APE9-dist-in 4.093 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 A 363 302 9 0 0 9 [[202, 503]] 1.0 6unp Homo sapiens TKL_BMPR2_HUMAN TKL 1.2e-74 257.3 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BRAF BRAF_HUMAN 4MNFA P15056 449 720 766.0 29L:801 Type1 None DFGin 6.831 14.084 BLAminus DFGAsp-rot-in -138.14, -173.65 64.87, 78.28 205.18, -20.03 -102.21, 29.93 290.33, 73.26 -66.38, -51.46 in-in in 8.582 Saltbr-in 2.768 HRD-in -70.14, -50.01 76.68, -10.07 in-in-none SNCiin in-none ActLoopNT-in 2.834 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 142.76 APE8-rot-in 296.87 APE67-dihe-in -62.48, -28.21 -57.0, -49.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 V600E None None XRAY 2.802 0.215 0.275 A 329 257 15 0 0 15 [[457, 716]] 1.0 4mnf Homo sapiens TKL_BRAF_HUMAN TKL 1.5e-81 279.9 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 2OICC Q9NWZ3 161 458 460.0 STU:3 Type1 None DFGin 7.642 14.512 BLAminus DFGAsp-rot-in -134.38, -175.33 55.45, 88.83 204.91, -7.02 -103.9, 2.57 299.42, 100.27 -42.77, 999.0 in-in in 9.176 Saltbr-in 3.297 HRD-in -70.98, -49.49 84.28, -16.44 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -109.35, 145.04 APE9-dihe-na 142.04, -179.34 APE8-dihe-in -123.52, 118.39 APE8-rot-in 307.07 APE67-dihe-in -69.67, -21.31 -65.38, -24.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.567 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.4 0.226 0.278 C 301 280 18 0 0 10 [[183, 456]] 1.0 2oic Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K72B Q9NWZ3 165 458 460.0 6QY:504 Type1 None DFGin 6.918 14.797 BLAminus DFGAsp-rot-in -126.83, 172.54 63.1, 86.46 237.93, -47.45 -103.47, 19.92 308.93, 101.56 -64.92, -35.48 in-in in 8.872 Saltbr-in 3.087 HRD-in -67.63, -51.12 79.83, -9.89 in-in-none SNCiin in-none ActLoopNT-in 2.869 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 146.4 APE9-dihe-na 138.09, -173.14 APE8-dihe-in -106.76, 111.81 APE8-rot-in 311.41 APE67-dihe-in -65.66, -17.88 -41.88, -47.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.406 APE9-dist-in 4.084 None TPO345,SEP346 TPO345,SEP346 XRAY 2.22 0.215 0.225 B 301 267 27 0 0 14 [[183, 456]] 1.0 5k72 Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 5K7GB Q9NWZ3 165 458 460.0 6R0:503 Type1 None DFGin 6.983 14.576 BLAminus DFGAsp-rot-in -125.44, 169.29 65.46, 85.11 239.35, -39.15 -103.67, 20.54 309.11, 102.13 -65.88, -35.43 in-in in 8.895 Saltbr-in 3.133 HRD-in -66.71, -50.75 79.24, -11.2 in-in-none SNCiin in-none ActLoopNT-in 2.855 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 145.13 APE9-dihe-na 139.01, -174.96 APE8-dihe-in -106.13, 110.24 APE8-rot-in 312.27 APE67-dihe-in -64.1, -19.47 -39.24, -50.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.428 APE9-dist-in 4.132 None TPO345,SEP346 TPO345,SEP346 XRAY 2.23 0.207 0.227 B 301 275 19 0 0 14 [[183, 456]] 1.0 5k7g Homo sapiens TKL_IRAK4_HUMAN TKL 4.2e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.973 14.137 BLAminus DFGAsp-rot-in -129.45, 177.84 61.74, 86.54 214.43, -46.52 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.098 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.189 APE11-dist-in 11.686 APE10-dist-in 6.444 APE9-dist-in 4.332 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305 297 0 0 0 0 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.4e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGDA Q9NWZ3 165 458 460.0 J87:60501 Type1 None DFGin 6.848 14.184 BLAminus DFGAsp-rot-in -141.24, -173.92 62.73, 75.05 193.7, 8.25 -96.24, 8.11 294.89, 87.75 -42.03, -35.64 in-in in 8.834 Saltbr-in 3.375 HRD-in -75.12, -50.55 72.64, 0.08 in-in-none SNCiin in-none ActLoopNT-in 2.678 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.37, -20.6 999.0, -46.07 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.184 0.23 A 302 268 26 0 0 16 [[183, 456]] 1.0 6egd Homo sapiens TKL_IRAK4_HUMAN TKL 2.7e-83 285.5 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U97A Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.218 14.495 BLAminus DFGAsp-rot-in -133.4, -177.52 44.45, 65.76 191.08, -3.01 -75.86, 30.58 295.34, 78.33 -61.24, -17.68 in-in in 9.111 Saltbr-in 2.796 HRD-in -81.28, -51.43 74.22, 0.69 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.32, 150.98 APE9-dihe-na 154.49, -177.45 APE8-dihe-in -96.07, 115.4 APE8-rot-in 303.66 APE67-dihe-in -67.54, -17.85 -61.65, -28.02 APE12-dist-in 9.909 APE11-dist-in 11.839 APE10-dist-in 7.032 APE9-dist-in 3.824 D311N None None XRAY 2.65 0.206 0.251 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u97 Homo sapiens TKL_IRAK4_HUMAN TKL 3.1e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4U9AA Q9NWZ3 166 458 460.0 STU:501 Type1 None DFGin 7.045 14.907 BLAminus DFGAsp-rot-in -101.08, -157.39 29.3, 88.18 197.77, -8.47 -95.05, 25.51 282.71, 82.79 -64.14, 4.87 in-in in 8.998 Saltbr-in 3.226 HRD-in -68.43, -44.05 62.5, 13.64 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.36, 146.03 APE9-dihe-na 162.68, -156.1 APE8-dihe-in -121.4, 112.37 APE8-rot-in 316.45 APE67-dihe-in -59.48, -18.83 -58.3, -38.15 APE12-dist-in 9.983 APE11-dist-in 11.951 APE10-dist-in 7.219 APE9-dist-in 3.878 D311N None None XRAY 2.8 0.185 0.24 A 312 272 21 0 0 8 [[183, 456]] 1.0 4u9a Homo sapiens TKL_IRAK4_HUMAN TKL 3.1e-83 285.4 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL RIPK3 RIPK3_HUMAN 7MX3A Q9Y572 12 314 518.0 ZOV:401 Type1.5_Back None DFGin 6.222 13.909 BLAminus DFGAsp-rot-in -152.35, -176.12 58.98, 65.68 186.81, 73.74 -88.59, 21.74 285.92, 83.22 -75.2, -29.2 in-in in 7.967 Saltbr-in 2.917 HRD-in -70.69, -48.21 67.95, 8.04 in-in-none SNCiin in-none ActLoopNT-in 3.202 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.66, -25.03 999.0, -33.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 A 319 292 11 0 0 10 [[21, 285]] 1.0 7mx3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.6e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_HUMAN 7MX3C Q9Y572 9 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.324 14.409 BLAminus DFGAsp-rot-in -144.06, -179.33 56.59, 66.53 185.77, 1.86 -89.63, 30.65 289.6, 92.66 -94.37, -38.42 in-in in 7.368 Saltbr-in 3.19 HRD-in -62.63, -60.0 65.83, 13.04 in-in-none SNCiin in-none ActLoopNT-in 3.154 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.63, -27.61 999.0, -44.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 C 319 285 18 0 0 10 [[21, 285]] 1.0 7mx3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.6e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_HUMAN 7MX3D Q9Y572 12 311 518.0 ZOV:401 Type1.5_Back None DFGin 6.158 13.934 BLAminus DFGAsp-rot-in -152.67, -168.91 60.99, 69.08 190.06, -0.83 -93.05, 21.87 286.54, 121.22 -73.96, -39.13 in-in in 8.115 Saltbr-in 3.229 HRD-in -81.46, -31.71 66.32, -56.05 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.09 APE8-rot-in 303.22 APE67-dihe-in -61.12, -38.55 -55.88, -51.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C3S,C110A None None XRAY 3.23 0.244 0.285 D 319 280 19 0 0 14 [[21, 285]] 1.0 7mx3 Homo sapiens TKL_RIPK3_HUMAN TKL 7.6e-66 228.4 1 265 265 159 160 161 163 165 50 60 64 139 141 140 142 203 189 184 183 182 181 180 179 178 95 Receptor-interacting serine/threonine-protein kinase 3
TKL TGFBR1 TGFR1_HUMAN 3HMMA P36897 201 498 503.0 855:60857 Type1 None DFGin 6.119 13.049 BLAminus DFGAsp-rot-in -127.07, -168.91 53.99, 65.82 202.78, 18.02 -94.96, 13.15 305.68, 3.69 -60.53, -23.27 in-in in 8.024 Saltbr-in 2.812 HRD-in -74.05, -51.32 76.01, -1.97 in-in-none SNCiin in-none ActLoopNT-in 2.934 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.63 APE8-dihe-in -79.78, 120.6 APE8-rot-in 300.84 APE67-dihe-in -55.11, -37.41 -48.22, -47.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.917 None None None XRAY 1.7 0.223 0.241 A 303 293 5 0 0 5 [[205, 494]] 1.0 3hmm Homo sapiens TKL_TGFBR1_HUMAN TKL 3.2e-85 291.8 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3TZMA P36897 200 496 503.0 085:1 Type1 None DFGin 6.065 13.106 BLAminus DFGAsp-rot-in -122.58, -169.81 59.22, 59.29 189.29, 30.76 -91.38, 11.48 304.6, 5.41 -64.05, -23.93 in-in in 7.963 Saltbr-in 2.833 HRD-in -81.31, -50.79 80.1, -5.96 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -87.36, 160.54 APE9-dihe-na 102.22, -177.2 APE8-dihe-in -87.37, 126.2 APE8-rot-in 298.62 APE67-dihe-in -59.36, -31.96 -58.47, -41.28 APE12-dist-none 999.0 APE11-dist-in 12.238 APE10-dist-in 6.184 APE9-dist-in 3.825 None None None XRAY 1.7 0.172 0.205 A 309 295 2 0 0 2 [[205, 494]] 1.0 3tzm Homo sapiens TKL_TGFBR1_HUMAN TKL 3.5e-85 291.7 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 5QINA P37173 240 541 567.0 J2V:601 Type1 None DFGin 7.432 13.692 BLAminus DFGAsp-rot-in -160.38, -171.51 70.13, 63.56 200.22, 32.43 -97.31, 22.31 300.17, 115.61 -64.51, -28.45 in-in in 7.753 Saltbr-in 2.968 HRD-in -64.72, -51.48 70.07, 3.51 in-in-none SNCiin in-none ActLoopNT-in 2.945 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -105.98, 157.24 APE9-dihe-na 110.69, -170.54 APE8-dihe-in -92.43, 119.77 APE8-rot-in 303.14 APE67-dihe-in -57.21, -32.74 -53.66, -41.1 APE12-dist-none 999.0 APE11-dist-in 12.194 APE10-dist-in 6.1 APE9-dist-in 3.918 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 1.57 0.188 0.203 A 316 295 7 0 0 2 [[244, 540]] 1.0 5qin Homo sapiens TKL_TGFBR2_HUMAN TKL 2e-77 266.3 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TKL TNNI3K TNI3K_HUMAN 4YFFA Q59H18 445 726 835.0 4CV:801 Type1 None DFGin 6.896 13.887 BLAminus DFGAsp-rot-in -127.46, 175.49 57.0, 94.25 200.01, -8.09 -101.84, 21.43 285.11, 76.86 -67.58, -12.19 in-in in 8.305 Saltbr-in 2.573 HRD-in -72.29, -48.61 68.2, 11.99 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.81 APE8-rot-na 181.89 APE67-dihe-in -64.26, -21.67 -83.98, -17.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.07 0.211 0.251 A 311 264 18 0 0 11 [[463, 721]] 1.0 4yff Homo sapiens TKL_TNNI3K_HUMAN TKL 1.6e-77 266.7 1 267 267 605 606 607 609 611 490 509 513 585 587 586 588 647 634 629 628 627 626 625 624 623 540 Serine/threonine-protein kinase TNNI3K
TKL TNNI3K TNI3K_HUMAN 4YFFB Q59H18 445 726 835.0 4CV:801 Type1 None DFGin 6.848 13.882 BLAminus DFGAsp-rot-in -128.82, 174.1 57.67, 94.34 197.25, -9.76 -100.02, 21.13 285.48, 77.01 -67.5, -10.8 in-in in 8.358 Saltbr-in 2.603 HRD-in -72.09, -48.38 68.6, 12.37 in-in-none SNCiin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 137.74 APE8-rot-none 999.0 APE67-dihe-in -59.76, -26.5 -86.26, -18.43 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.07 0.211 0.251 B 311 264 18 0 0 12 [[463, 721]] 1.0 4yff Homo sapiens TKL_TNNI3K_HUMAN TKL 1.6e-77 266.7 1 267 267 605 606 607 609 611 490 509 513 585 587 586 588 647 634 629 628 627 626 625 624 623 540 Serine/threonine-protein kinase TNNI3K
TKL TNNI3K TNI3K_HUMAN 6B5JB Q59H18 445 726 835.0 CV4:801 Type1 None DFGin 6.776 13.884 BLAminus DFGAsp-rot-in -127.39, 170.23 63.58, 89.42 196.19, -2.98 -96.67, 32.19 290.95, 72.96 -66.8, -26.81 in-in in 8.616 Saltbr-in 3.049 HRD-in -67.53, -48.98 70.48, -12.85 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none nonTYR APEdihe_aanai APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.15 APE8-rot-na 200.19 APE67-dihe-in -61.72, -25.21 -84.18, -18.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.97 0.204 0.258 B 311 264 18 0 0 12 [[463, 721]] 1.0 6b5j Homo sapiens TKL_TNNI3K_HUMAN TKL 1.6e-77 266.7 1 267 267 605 606 607 609 611 490 509 513 585 587 586 588 647 634 629 628 627 626 625 624 623 540 Serine/threonine-protein kinase TNNI3K
TYR CSK CSK_HUMAN 3D7UA P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.024 13.117 BLAminus DFGAsp-rot-in -139.73, -167.84 53.51, 74.77 198.83, -39.22 -92.77, 23.91 306.2, 90.91 -52.72, -52.05 in-in in 8.261 Saltbr-in 2.543 HRD-in -75.91, -39.41 59.37, 3.93 in-in-none SNCiin in-none ActLoopNT-in 2.903 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 146.18 APE9-dihe-in -90.57, 133.68 APE8-dihe-in -63.86, 107.61 APE8-rot-na 30.93 APE67-dihe-in -66.76, -13.54 -46.29, -47.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.896 APE9-dist-na 4.945 None None None XRAY 4.111 0.294 0.302 A 263 257 6 0 0 6 [[195, 442]] 1.0 3d7u Homo sapiens TYR_CSK_HUMAN TYR 9.9e-88 299.8 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR CSK CSK_HUMAN 3D7UC P41240 188 450 450.0 No_ligand No_ligand None DFGin 7.024 13.118 BLAminus DFGAsp-rot-in -139.69, -167.9 53.63, 74.8 198.79, -39.14 -92.81, 23.87 306.29, 90.94 -52.77, -51.99 in-in in 8.262 Saltbr-in 2.543 HRD-in -75.91, -39.47 59.39, 4.04 in-in-none SNCiin in-none ActLoopNT-in 2.905 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 146.11 APE9-dihe-in -90.53, 133.8 APE8-dihe-in -64.03, 107.64 APE8-rot-na 30.96 APE67-dihe-in -66.6, -13.57 -46.35, -47.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.897 APE9-dist-na 4.945 None None None XRAY 4.111 0.294 0.302 C 263 257 6 0 0 6 [[195, 442]] 1.0 3d7u Homo sapiens TYR_CSK_HUMAN TYR 9.9e-88 299.8 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR EGFR EGFR_HUMAN 2ITNA P00533 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.283 15.235 BLAminus DFGAsp-rot-in -127.19, -173.38 63.95, 79.84 214.57, -37.08 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.274 Saltbr-in 3.408 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.674 G719S None None XRAY 2.47 0.201 0.267 A 327 304 9 0 0 9 [[712, 970]] 1.0 2itn Homo sapiens TYR_EGFR_HUMAN TYR 9.9e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITVA P00533 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.216 15.481 BLAminus DFGAsp-rot-in -132.41, -173.63 61.69, 81.35 197.88, 4.24 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.584 Saltbr-in 3.462 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.569 L858R None None XRAY 2.47 0.197 0.242 A 327 303 9 0 0 9 [[712, 970]] 1.0 2itv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6JX4A P00533 696 1018 1210.0 YY3:1101 Type1 None DFGin 6.538 15.295 BLAminus DFGAsp-rot-in -153.26, -174.41 59.27, 71.1 210.89, 73.12 -94.69, 11.38 288.28, 101.84 -61.51, -40.3 in-in in 8.089 Saltbr-in 3.167 HRD-in -72.1, -56.13 75.51, 1.81 in-in-none SNCiin in-none ActLoopNT-in 2.76 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 44.4 APE9-dihe-in -64.43, 143.52 APE8-dihe-in -93.62, 106.36 APE8-rot-na 34.75 APE67-dihe-in -65.07, -25.73 -81.11, -32.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.137 APE9-dist-na 7.793 T790M None None XRAY 2.531 0.213 0.245 A 331 315 8 0 0 8 [[712, 970]] 1.0 6jx4 Homo sapiens TYR_EGFR_HUMAN TYR 8.6e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7VRAA P00533 696 1018 1210.0 I0A:1101 Type1 None DFGin 6.329 14.98 BLAminus DFGAsp-rot-in -141.39, -166.19 53.63, 67.86 201.93, -31.44 -86.81, 26.91 290.4, 77.76 -61.4, -34.62 in-in in 8.262 Saltbr-in 2.7 HRD-in -73.36, -43.6 68.83, -12.22 in-in-none SNCiin in-none ActLoopNT-in 2.816 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 128.24 APE9-dihe-in -138.53, 146.25 APE8-dihe-in -81.73, 106.37 APE8-rot-na 16.59 APE67-dihe-in -71.3, -8.33 -70.5, -37.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.507 APE9-dist-na 6.955 T790M,C797S None None XRAY 2.41 0.221 0.245 A 331 289 15 0 0 11 [[712, 970]] 1.0 7vra Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7VREA P00533 696 1018 1210.0 7VH:1101 Type1 None DFGin 6.536 14.855 BLAminus DFGAsp-rot-in -135.27, -171.61 56.81, 74.8 201.97, -34.69 -92.4, 15.96 289.99, 73.74 -54.73, -16.72 in-in in 8.209 Saltbr-in 2.854 HRD-in -71.51, -50.16 76.97, -3.83 in-in-none SNCiin in-none ActLoopNT-in 2.785 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 43.94 APE9-dihe-in -79.86, 134.45 APE8-dihe-in -82.74, 99.99 APE8-rot-na 32.04 APE67-dihe-in -80.29, -2.71 -71.55, -29.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.336 APE9-dist-na 7.113 T790M,C797S None None XRAY 2.507 0.203 0.242 A 331 312 11 0 0 8 [[712, 970]] 1.0 7vre Homo sapiens TYR_EGFR_HUMAN TYR 3.5e-87 298.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9KLWA P00533 696 1019 1210.0 A1L53:61101 Type1 None DFGin 5.36 15.016 BLAminus DFGAsp-rot-in -137.92, -173.21 68.95, 86.53 203.41, -65.45 -103.04, 23.39 302.9, 100.52 -66.02, -20.59 in-in in 8.729 Saltbr-in 3.41 HRD-in -69.44, -47.22 66.72, 12.67 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 149.08 APE8-dihe-in -82.92, 74.1 APE8-rot-na 34.98 APE67-dihe-in -75.3, -8.48 -60.53, -40.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.69 T790M,L858R None None XRAY 2.67 0.2 0.257 A 330 298 14 0 0 13 [[712, 970]] 1.0 9klw Homo sapiens TYR_EGFR_HUMAN TYR 8.9e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2J5FA P00533 696 1020 1210.0 DJK:3021 Type1 None DFGin 5.657 14.384 BLAminus DFGAsp-rot-in -144.79, -170.55 64.0, 79.04 230.57, -89.08 -97.73, 24.0 296.97, 99.2 -43.96, -47.9 in-in in 8.267 Saltbr-in 2.813 HRD-in -61.54, -44.58 69.15, -3.0 in-in-none SNCiin in-none ActLoopNT-in 2.636 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 173.56 APE9-dihe-in -112.83, 120.26 APE8-dihe-in -93.5, 101.2 APE8-rot-na 33.0 APE67-dihe-in -64.88, -16.77 -72.19, -43.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.227 APE9-dist-na 7.146 None None None XRAY 3.0 0.194 0.246 A 327 309 8 0 0 8 [[712, 970]] 1.0 2j5f Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6VHNA P00533 696 1019 1210.0 QQJ:1101 Type1 None DFGin 6.268 15.406 BLAminus DFGAsp-rot-in -137.01, -168.66 62.81, 80.02 205.49, -45.16 -103.64, 23.1 296.88, 98.97 -61.22, -32.89 in-in in 8.718 Saltbr-in 2.854 HRD-in -76.27, -52.37 76.32, -0.98 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.2 APE8-dihe-in -87.73, 89.87 APE8-rot-na 30.35 APE67-dihe-in -72.35, -2.54 -65.87, -41.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.437 None None None XRAY 2.4 0.199 0.2 A 327 286 18 0 0 13 [[712, 970]] 1.0 6vhn Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6VHPA P00533 696 1019 1210.0 QP1:1101 Type1 None DFGin 6.015 15.357 BLAminus DFGAsp-rot-in -142.26, -172.24 60.71, 82.75 208.07, -49.09 -104.59, 30.45 301.25, 87.72 -60.33, -51.94 in-in in 8.978 Saltbr-in 2.908 HRD-in -76.89, -42.36 67.95, -9.7 in-in-none SNCiin in-none ActLoopNT-in 3.083 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 114.68 APE9-dihe-in -145.42, 154.51 APE8-dihe-in -84.79, 102.47 APE8-rot-na 20.66 APE67-dihe-in -73.32, -7.85 -65.47, -47.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.969 APE9-dist-na 6.918 None None None XRAY 3.6 0.184 0.218 A 327 308 5 0 0 5 [[712, 970]] 1.0 6vhp Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8G63A P00533 696 1017 1210.0 YXT:1101 Type1 None DFGin 5.529 14.747 BLAminus DFGAsp-rot-in -143.24, -159.19 52.58, 83.43 188.6, 54.71 -103.22, 21.32 305.76, 90.64 -45.28, -71.59 in-in in 8.933 Saltbr-in 2.765 HRD-in -81.87, -48.78 71.13, -4.89 in-in-none SNCiin in-none ActLoopNT-in 2.615 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 172.53 APE8-dihe-in -91.35, 75.86 APE8-rot-na 29.34 APE67-dihe-in -73.76, 1.1 -57.31, -35.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.515 None None None XRAY 2.5 0.21 0.257 A 327 280 21 0 0 14 [[712, 970]] 1.0 8g63 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9DM8A P00533 696 1017 1210.0 A1A6K:1101 Type1 None DFGin 6.251 14.38 BLAminus DFGAsp-rot-in -129.4794, -169.6864 63.6629, 84.7768 196.5704, -11.0134 -102.6451, 27.7661 289.3356, 94.5342 -67.8271, -26.1337 in-in in 8.144 Saltbr-in 2.785 HRD-in -78.3814, -49.5717 72.7609, 1.2004 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 120.6585 APE9-dihe-in -135.8511, 150.669 APE8-dihe-in -78.3741, 83.2772 APE8-rot-na 33.5804 APE67-dihe-in -74.2341, -7.8324 -57.956, -39.3058 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.668 APE9-dist-na 6.851 None None None XRAY 2.13 0.21 0.214 A 327 287 15 0 0 9 [[712, 970]] 1.0 9dm8 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NGPA P00533 698 1018 1210.0 A1BX7:1101 Type1 None DFGin 6.167 14.553 BLAminus DFGAsp-rot-in -137.6061, -165.7411 59.368, 87.1237 201.0371, -20.9971 -103.844, 20.2902 290.0017, 98.7291 -66.9504, -6.6198 in-in in 8.088 Saltbr-in 2.592 HRD-in -79.9827, -46.422 69.693, 0.9105 in-in-none SNCiin in-none ActLoopNT-in 2.87 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 101.389 APE8-rot-na 32.6074 APE67-dihe-in -79.6247, -5.3085 -66.9439, -33.3886 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.4 0.209 0.238 A 327 281 18 0 0 14 [[712, 970]] 1.0 9ngp Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NHWA P00533 698 1017 1210.0 A1BYD:1101 Type1 None DFGin 6.053 15.233 BLAminus DFGAsp-rot-in -144.87, -175.31 63.29, 77.05 198.65, -34.83 -97.54, 24.54 296.32, 92.45 -60.8, -21.57 in-in in 8.651 Saltbr-in 2.717 HRD-in -72.16, -41.92 62.16, 7.57 in-in-none SNCiin in-none ActLoopNT-in 2.897 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.95 APE8-dihe-in -67.02, 107.82 APE8-rot-na 338.68 APE67-dihe-in -78.27, -0.53 -71.56, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.576 None None None XRAY 2.73 0.239 0.268 A 327 280 18 0 0 8 [[712, 970]] 1.0 9nhw Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NISA P00533 696 1016 1210.0 A1BYK:1101 Type1 None DFGin 6.187 15.633 BLAminus DFGAsp-rot-in -132.6, -171.59 61.46, 82.06 204.14, -41.31 -102.11, 30.13 293.65, 92.81 -70.22, -9.04 in-in in 8.824 Saltbr-in 2.777 HRD-in -74.0, -46.82 70.75, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.962 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 151.12 APE8-dihe-in -77.06, 100.01 APE8-rot-na 28.66 APE67-dihe-in -74.77, -0.45 -66.74, -40.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.61 None None None XRAY 2.23 0.235 0.262 A 327 281 17 0 0 10 [[712, 970]] 1.0 9nis Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NJ7A P00533 698 1017 1210.0 A1BYL:1201 Type1 None DFGin 6.064 15.618 BLAminus DFGAsp-rot-in -139.58, -169.66 55.85, 84.13 202.41, -38.11 -103.94, 33.72 294.22, 89.03 -68.52, -21.81 in-in in 8.785 Saltbr-in 2.695 HRD-in -73.41, -43.75 67.32, 4.02 in-in-none SNCiin in-none ActLoopNT-in 2.833 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.66 APE8-dihe-in -73.6, 99.04 APE8-rot-na 28.02 APE67-dihe-in -69.1, -11.18 -63.58, -37.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.492 None None None XRAY 2.53 0.233 0.281 A 327 266 30 0 0 15 [[712, 970]] 1.0 9nj7 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NJNA P00533 698 1017 1210.0 A1BYS:1101 Type1 None DFGin 6.052 15.492 BLAminus DFGAsp-rot-in -138.03, -171.71 61.23, 82.93 202.08, -36.03 -102.84, 28.68 295.04, 92.18 -66.73, -16.96 in-in in 8.924 Saltbr-in 3.498 HRD-in -75.24, -45.9 66.95, 7.02 in-in-none SNCiin in-none ActLoopNT-in 2.929 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.33 APE8-dihe-in -71.72, 99.92 APE8-rot-na 26.75 APE67-dihe-in -76.44, 0.7 -63.78, -39.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.484 None None None XRAY 2.24 0.242 0.275 A 327 268 28 0 0 13 [[712, 970]] 1.0 9njn Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9NM0A P00533 697 1018 1210.0 VO7:1101 Type1 None DFGin 6.308 15.402 BLAminus DFGAsp-rot-in -140.17, -167.49 58.79, 90.01 221.52, -35.01 -111.11, 22.07 294.08, 94.65 -58.39, -24.66 in-in in 8.079 Saltbr-in 3.12 HRD-in -72.56, -49.62 74.29, -11.19 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 98.9 APE8-rot-na 32.89 APE67-dihe-in -82.2, -4.65 -68.26, -37.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.59 0.209 0.247 A 327 273 27 0 0 16 [[712, 970]] 1.0 9nm0 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9OS6A P00533 697 1017 1210.0 A1CEA:1101 Type1 None DFGin 5.787 14.723 BLAminus DFGAsp-rot-in -149.68, -169.55 59.63, 82.89 203.29, -45.37 -107.09, 37.79 302.53, 107.91 -67.77, -19.45 in-in in 8.65 Saltbr-in 2.864 HRD-in -73.22, -47.28 69.98, 3.7 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.25 APE8-dihe-in -84.48, 84.59 APE8-rot-na 30.42 APE67-dihe-in -71.55, 6.59 -60.52, -46.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.437 None None None XRAY 2.75 0.211 0.255 A 327 277 22 0 0 14 [[712, 970]] 1.0 9os6 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9H46A P00533 696 1019 1210.0 A1ISA:1101 Type1 None DFGin 6.363 15.169 BLAminus DFGAsp-rot-in -149.47, -177.58 62.62, 58.11 238.48, 62.72 -90.1, 3.13 314.38, 111.86 -47.48, -44.04 in-in in 8.743 Saltbr-in 3.221 HRD-in -63.57, -45.69 65.43, -1.15 in-in-none SNCiin in-none ActLoopNT-in 2.657 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.98 APE8-dihe-in -85.78, 71.07 APE8-rot-na 35.5 APE67-dihe-in -68.16, -32.18 -60.78, -38.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.139 None None None XRAY 3.163 0.214 0.256 A 328 305 11 0 0 11 [[712, 970]] 1.0 9h46 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7UKVA P00533 696 1018 1210.0 ZRT:1101 Type1 None DFGin 5.936 15.094 BLAminus DFGAsp-rot-in -138.2, -168.81 62.37, 83.02 221.86, -42.63 -103.85, 24.26 298.25, 88.25 -61.11, -23.87 in-in in 8.689 Saltbr-in 2.994 HRD-in -78.76, -49.38 70.66, 2.89 in-in-none SNCiin in-none ActLoopNT-in 2.973 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 127.73 APE9-dihe-in -144.8, 152.44 APE8-dihe-in -81.13, 94.3 APE8-rot-na 29.19 APE67-dihe-in -72.65, 4.24 -61.82, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.234 APE9-dist-na 6.419 None None None XRAY 2.4 0.213 0.243 A 328 290 13 0 0 6 [[712, 970]] 1.0 7ukv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZAUA P00533 698 1017 1210.0 YY3:1101 Type1 None DFGin 6.017 15.47 BLAminus DFGAsp-rot-in -144.79, -170.19 56.78, 87.23 210.08, -37.44 -105.06, 22.23 291.67, 100.52 -61.25, -22.95 in-in in 9.092 Saltbr-in 3.506 HRD-in -80.01, -54.39 75.7, 11.54 in-in-none SNCiin in-none ActLoopNT-in 2.891 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 172.16 APE9-dihe-in -149.48, 142.85 APE8-dihe-in -76.13, 94.93 APE8-rot-na 357.17 APE67-dihe-in -79.77, -9.04 -61.73, -40.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.194 APE9-dist-na 6.955 None None None XRAY 2.8 0.196 0.244 A 330 283 14 0 0 5 [[712, 970]] 1.0 4zau Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7B85A P00533 697 1020 1210.0 R28:1101 Type1 None DFGin 5.854 14.557 BLAminus DFGAsp-rot-in -137.84, -174.1 60.63, 85.07 202.25, -7.73 -103.17, 26.09 294.86, 88.23 -63.8, -24.92 in-in in 7.92 Saltbr-in 2.748 HRD-in -73.34, -48.14 69.22, 2.13 in-in-none SNCiin in-none ActLoopNT-in 3.018 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 121.75 APE9-dihe-in -146.0, 163.38 APE8-dihe-in -89.43, 103.15 APE8-rot-na 22.0 APE67-dihe-in -71.22, -17.13 -66.77, -37.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.554 APE9-dist-na 6.798 None None None XRAY 2.5 0.216 0.244 A 333 312 6 0 0 2 [[712, 970]] 1.0 7b85 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6S9BA P00533 697 1019 1210.0 L1H:1101 Type1 None DFGin 6.118 15.018 BLAminus DFGAsp-rot-in -148.24, -172.87 65.26, 88.24 211.07, -49.65 -111.59, 23.4 302.91, 91.25 -69.84, -29.04 in-in in 8.68 Saltbr-in 2.766 HRD-in -77.95, -44.62 67.36, 12.41 in-in-none SNCiin in-none ActLoopNT-in 2.789 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 130.6 APE9-dihe-in -136.99, 149.82 APE8-dihe-in -88.88, 86.38 APE8-rot-na 33.73 APE67-dihe-in -72.04, -14.11 -61.18, -35.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.083 APE9-dist-na 7.2 T790M,L858R,E865A,E866A,K867A None None XRAY 3.25 0.186 0.232 A 326 291 15 0 0 12 [[712, 970]] 1.0 6s9b Homo sapiens TYR_EGFR_HUMAN TYR 4.5e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6S9CA P00533 696 1019 1210.0 L1K:61101 Type1 None DFGin 5.825 14.722 BLAminus DFGAsp-rot-in -137.24, -177.45 69.22, 83.47 201.5, -39.64 -102.5, 27.64 296.66, 90.76 -71.56, -8.94 in-in in 8.526 Saltbr-in 2.833 HRD-in -60.53, -44.79 71.19, 1.46 in-in-none SNCiin in-none ActLoopNT-in 2.756 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 105.07 APE9-dihe-in -124.15, 154.71 APE8-dihe-in -82.6, 76.59 APE8-rot-na 34.11 APE67-dihe-in -73.9, -13.53 -58.44, -39.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.508 APE9-dist-na 7.756 T790M,L858R,E865A,E866A,K867A None None XRAY 2.73 0.202 0.225 A 329 299 14 0 0 12 [[712, 970]] 1.0 6s9c Homo sapiens TYR_EGFR_HUMAN TYR 4.7e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ4A P00533 697 1018 1210.0 3QW:1101 Type1 None DFGin 5.642 14.869 BLAminus DFGAsp-rot-in -140.69, -172.61 68.51, 86.31 198.63, -70.82 -99.76, 22.2 296.02, 102.47 -65.67, -16.31 in-in in 8.584 Saltbr-in 2.803 HRD-in -56.37, -48.84 66.69, -1.93 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.29 APE8-dihe-in -86.76, 81.28 APE8-rot-na 21.53 APE67-dihe-in -69.94, -5.61 -53.89, -50.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.202 T790M,L858R,E865A,E866A,K867A None None XRAY 2.78 0.19 0.226 A 331 299 17 0 0 14 [[712, 970]] 1.0 4rj4 Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ7A P00533 697 1018 1210.0 3R1:1102 Type1 None DFGin 6.017 14.69 BLAminus DFGAsp-rot-in -136.51, -172.32 66.59, 81.87 198.8, 17.58 -97.51, 17.72 294.15, 102.13 -65.84, -16.96 in-in in 8.348 Saltbr-in 3.238 HRD-in -60.19, -50.96 69.31, -0.58 in-in-none SNCiin in-none ActLoopNT-in 2.741 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.16 APE8-dihe-in -78.25, 70.95 APE8-rot-na 29.95 APE67-dihe-in -67.71, -3.19 -45.43, -49.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.219 T790M,L858R,E865A,E866A,K867A None None XRAY 2.55 0.207 0.234 A 331 295 19 0 0 14 [[712, 970]] 1.0 4rj7 Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ8A P00533 697 1018 1210.0 3QS:1102 Type1 None DFGin 5.739 14.839 BLAminus DFGAsp-rot-in -139.18, -167.47 68.29, 77.56 215.62, -58.37 -89.12, 10.26 294.1, 106.72 -54.86, -20.91 in-in in 8.396 Saltbr-in 2.794 HRD-in -60.49, -55.01 73.42, -2.13 in-in-none SNCiin in-none ActLoopNT-in 2.781 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.62 APE8-dihe-in -86.58, 81.4 APE8-rot-na 26.4 APE67-dihe-in -68.07, -3.17 -48.59, -54.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.12 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.197 0.226 A 331 298 18 0 0 14 [[712, 970]] 1.0 4rj8 Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5C8KA P00533 697 1018 1210.0 4YV:1101 Type1 None DFGin 5.618 14.865 BLAminus DFGAsp-rot-in -142.56, -168.74 65.75, 82.14 215.39, -72.66 -97.63, 22.27 300.75, 101.92 -60.4, -26.09 in-in in 8.741 Saltbr-in 2.765 HRD-in -67.41, -39.79 60.89, -7.73 in-in-none SNCiin in-none ActLoopNT-in 2.986 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.8 APE8-dihe-in -95.26, 73.85 APE8-rot-na 27.78 APE67-dihe-in -64.32, -5.28 -41.93, -56.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.159 T790M,L858R,E865A,E866A,K867A None None XRAY 3.0 0.202 0.251 A 331 300 17 0 0 15 [[712, 970]] 1.0 5c8k Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5C8MA P00533 697 1019 1210.0 4YW:1101 Type1 None DFGin 6.03 15.137 BLAminus DFGAsp-rot-in -139.93, -166.43 62.51, 82.79 209.75, -82.54 -104.18, 35.15 303.24, 104.63 -71.47, -7.58 in-in in 8.656 Saltbr-in 2.802 HRD-in -63.0, -55.16 74.91, -5.77 in-in-none SNCiin in-none ActLoopNT-in 3.092 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.92 APE8-dihe-in -91.72, 83.46 APE8-rot-na 23.85 APE67-dihe-in -63.98, -6.63 -55.14, -47.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.308 T790M,L858R,E865A,E866A,K867A None None XRAY 2.9 0.21 0.252 A 331 302 16 0 0 14 [[712, 970]] 1.0 5c8m Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5C8NA P00533 696 1019 1210.0 4YX:1102 Type1 None DFGin 5.55 14.849 BLAminus DFGAsp-rot-in -130.09, -164.08 61.96, 83.03 194.52, -13.47 -95.79, 18.7 301.11, 101.32 -62.83, -10.09 in-in in 8.554 Saltbr-in 2.837 HRD-in -74.54, -49.37 73.34, -0.43 in-in-none SNCiin in-none ActLoopNT-in 2.861 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.63 APE8-dihe-in -90.67, 83.94 APE8-rot-na 35.45 APE67-dihe-in -71.85, 0.66 -67.76, -45.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.237 T790M,L858R,E865A,E866A,K867A None None XRAY 2.401 0.204 0.258 A 331 300 17 0 0 14 [[712, 970]] 1.0 5c8n Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CALA P00533 697 1018 1210.0 4Z8:1101 Type1 None DFGin 5.497 14.495 BLAminus DFGAsp-rot-in -137.41, -172.89 65.78, 89.63 194.85, 14.87 -103.26, 18.8 297.84, 103.35 -65.07, -18.88 in-in in 8.735 Saltbr-in 2.949 HRD-in -63.06, -53.55 70.57, -1.46 in-in-none SNCiin in-none ActLoopNT-in 3.026 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.13 APE8-dihe-in -87.57, 76.27 APE8-rot-na 28.21 APE67-dihe-in -69.94, -3.46 -48.77, -46.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.071 T790M,L858R,E865A,E866A,K867A None None XRAY 2.7 0.206 0.227 A 331 300 17 0 0 15 [[712, 970]] 1.0 5cal Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CANA P00533 696 1019 1210.0 4ZB:1102 Type1 None DFGin 5.619 14.735 BLAminus DFGAsp-rot-in -142.73, -174.9 68.91, 93.29 192.6, -65.49 -106.76, 21.14 296.79, 103.43 -65.99, -14.88 in-in in 8.569 Saltbr-in 2.838 HRD-in -62.3, -49.88 68.9, -1.6 in-in-none SNCiin in-none ActLoopNT-in 2.799 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.26 APE8-dihe-in -87.26, 78.01 APE8-rot-na 20.78 APE67-dihe-in -67.65, -1.03 -49.32, -53.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.199 T790M,L858R,E865A,E866A,K867A None None XRAY 2.8 0.198 0.232 A 331 301 16 0 0 14 [[712, 970]] 1.0 5can Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAOA P00533 697 1019 1210.0 4ZG:1101 Type1 None DFGin 5.726 14.535 BLAminus DFGAsp-rot-in -132.0, -172.67 65.56, 80.31 197.46, 1.18 -104.95, 26.76 323.84, 105.62 -77.97, 14.2 in-in in 8.772 Saltbr-in 3.033 HRD-in -58.9, -58.41 76.18, -10.46 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.94 APE8-dihe-in -90.41, 73.41 APE8-rot-na 26.26 APE67-dihe-in -60.83, -6.66 -44.66, -55.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.42 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.203 0.231 A 331 300 19 0 0 16 [[712, 970]] 1.0 5cao Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAPA P00533 697 1019 1210.0 4ZH:1103 Type1 None DFGin 5.965 15.081 BLAminus DFGAsp-rot-in -134.45, -171.01 71.99, 88.37 206.45, 13.22 -110.44, 24.81 303.88, 121.07 -72.28, -6.86 in-in in 8.389 Saltbr-in 2.786 HRD-in -63.56, -57.8 76.6, -10.03 in-in-none SNCiin in-none ActLoopNT-in 3.14 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.82 APE8-dihe-in -83.94, 76.0 APE8-rot-na 26.21 APE67-dihe-in -67.04, -0.42 -50.69, -48.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.483 T790M,L858R,E865A,E866A,K867A None None XRAY 2.4 0.191 0.213 A 331 303 15 0 0 15 [[712, 970]] 1.0 5cap Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5EM7A P00533 696 1019 1210.0 5Q4:1102 Type1 None DFGin 6.063 14.737 BLAminus DFGAsp-rot-in -135.51, -175.43 63.24, 90.16 193.12, -71.34 -107.26, 25.15 291.83, 97.24 -73.87, -13.09 in-in in 8.193 Saltbr-in 2.807 HRD-in -60.94, -47.98 66.46, -2.63 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 140.59 APE8-dihe-in -87.95, 81.76 APE8-rot-na 24.14 APE67-dihe-in -66.12, -4.01 -54.22, -49.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.23 T790M,L858R,E865A,E866A,K867A None None XRAY 2.81 0.19 0.216 A 331 300 17 0 0 14 [[712, 970]] 1.0 5em7 Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HCXA P00533 696 1018 1210.0 60B:1102 Type1 None DFGin 5.679 14.34 BLAminus DFGAsp-rot-in -134.75, -168.37 67.26, 84.11 208.87, -44.81 -97.03, 11.58 292.78, 109.41 -56.16, -12.04 in-in in 8.197 Saltbr-in 3.182 HRD-in -55.82, -53.35 72.1, 1.2 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.91 APE8-dihe-in -89.45, 69.04 APE8-rot-na 28.83 APE67-dihe-in -67.35, -11.16 -46.21, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.3 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.194 0.223 A 331 298 17 0 0 14 [[712, 970]] 1.0 5hcx Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HCZA P00533 696 1019 1210.0 60E:1102 Type1 None DFGin 5.51 14.126 BLAminus DFGAsp-rot-in -138.48, -168.94 67.59, 84.64 207.01, -18.01 -98.68, 22.07 297.97, 107.23 -59.74, -32.24 in-in in 8.208 Saltbr-in 2.979 HRD-in -55.25, -49.19 68.73, 4.6 in-in-none SNCiin in-none ActLoopNT-in 2.777 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.77 APE8-dihe-in -87.19, 65.54 APE8-rot-na 27.65 APE67-dihe-in -64.96, -12.37 -40.06, -51.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.324 T790M,L858R,E865A,E866A,K867A None None XRAY 2.62 0.196 0.227 A 331 300 17 0 0 14 [[712, 970]] 1.0 5hcz Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITTA P00533 697 1019 1210.0 AEE:2020 Type1 None DFGin 5.936 14.965 BLAminus DFGAsp-rot-in -130.73, -162.83 54.09, 78.3 217.4, -56.39 -90.96, 8.6 295.86, 89.36 -44.57, 3.1 in-in in 8.368 Saltbr-in 2.867 HRD-in -70.65, -43.73 65.16, 6.34 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 122.78 APE8-dihe-in -88.12, 98.9 APE8-rot-na 27.6 APE67-dihe-in -72.01, -6.18 -71.82, -40.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.493 L858R None None XRAY 2.73 0.212 0.262 A 327 302 9 0 0 9 [[712, 970]] 1.0 2itt Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X26A P00533 697 1020 1210.0 7XO:1101 Type1 None DFGin 6.188 14.935 BLAminus DFGAsp-rot-in -153.57, -170.14 58.63, 70.59 228.77, 80.67 -94.54, 18.38 292.51, 110.93 -60.72, -39.59 in-in in 8.548 Saltbr-in 3.317 HRD-in -64.24, -45.47 69.82, 6.31 in-in-none SNCiin in-none ActLoopNT-in 2.835 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.99 APE8-dihe-in -94.19, 95.15 APE8-rot-na 32.94 APE67-dihe-in -63.12, -36.92 -65.94, -42.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.448 L858R None None XRAY 2.951 0.197 0.222 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x26 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X27A P00533 697 1020 1210.0 7XR:1101 Type1 None DFGin 6.089 14.567 BLAminus DFGAsp-rot-in -142.52, -171.15 59.08, 68.89 229.26, -83.61 -91.56, 16.87 296.22, 103.35 -59.61, -40.88 in-in in 8.476 Saltbr-in 3.407 HRD-in -67.74, -41.55 62.13, 9.32 in-in-none SNCiin in-none ActLoopNT-in 2.795 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 108.75 APE8-dihe-in -94.41, 99.92 APE8-rot-na 33.71 APE67-dihe-in -62.5, -41.39 -64.95, -42.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.156 L858R None None XRAY 2.952 0.205 0.238 A 327 302 9 0 0 9 [[712, 970]] 1.0 5x27 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X28A P00533 697 1020 1210.0 7XU:1101 Type1 None DFGin 6.242 14.981 BLAminus DFGAsp-rot-in -155.25, -168.54 56.92, 67.25 226.27, -88.21 -92.6, 16.38 291.1, 113.77 -60.0, -38.56 in-in in 8.766 Saltbr-in 2.872 HRD-in -64.09, -44.41 72.37, 3.05 in-in-none SNCiin in-none ActLoopNT-in 2.907 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.7 APE8-dihe-in -90.21, 91.04 APE8-rot-na 33.64 APE67-dihe-in -63.4, -43.04 -64.77, -43.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.502 L858R None None XRAY 2.952 0.211 0.25 A 327 310 9 0 0 9 [[712, 970]] 1.0 5x28 Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5XDLA P00533 696 1018 1210.0 8JC:1101 Type1 None DFGin 6.15 14.871 BLAminus DFGAsp-rot-in -146.3, -172.59 64.93, 71.28 209.97, -63.36 -94.1, 9.83 302.09, 99.18 -52.93, -42.05 in-in in 8.394 Saltbr-in 3.228 HRD-in -74.03, -53.77 76.73, 1.67 in-in-none SNCiin in-none ActLoopNT-in 3.156 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 59.31 APE8-rot-na 32.98 APE67-dihe-in -74.19, -13.64 -84.48, -30.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L858R None None XRAY 2.7 0.212 0.256 A 331 292 17 0 0 15 [[712, 970]] 1.0 5xdl Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9U8CD P00533 696 987 1210.0 A1L8T:61101 Type1 None DFGin 5.518 14.842 BLAminus DFGAsp-rot-in -152.89, -164.88 57.37, 59.02 209.68, -58.73 -76.65, 17.66 286.7, 98.09 -55.38, -41.88 in-in in 8.871 Saltbr-in 3.187 HRD-in -114.09, -29.54 63.53, -55.66 in-in-none SNCiin in-none ActLoopNT-in 3.462 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 146.4 APE8-dihe-in -82.7, 101.15 APE8-rot-na 29.1 APE67-dihe-in -63.15, -43.97 -69.62, -36.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.518 None None None XRAY 3.5 0.275 0.3 D 338 285 7 0 0 4 [[712, 970]] 1.0 9u8c Homo sapiens TYR_EGFR_HUMAN TYR 1.8e-85 292.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6D8EA P00533 696 1019 1210.0 FZP:1101 Type1.5_Back None DFGin 6.042 15.059 BLAminus DFGAsp-rot-in -138.11, -172.24 64.79, 63.43 232.55, 89.87 -86.6, 14.58 312.63, 81.25 -43.94, -59.79 in-in in 8.652 Saltbr-in 2.645 HRD-in -72.15, -45.77 63.05, 4.69 in-in-none SNCiin in-none ActLoopNT-in 3.016 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 112.81 APE9-dihe-in -139.79, 164.58 APE8-dihe-in -99.25, 105.5 APE8-rot-na 28.33 APE67-dihe-in -68.5, -6.69 -82.32, -41.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.866 APE9-dist-na 7.175 None None None XRAY 2.537 0.212 0.243 A 327 304 9 0 0 5 [[712, 970]] 1.0 6d8e Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RJ5A P00533 697 1019 1210.0 3QY:1101 Type1.5_Back None DFGin 6.144 15.305 BLAminus DFGAsp-rot-in -139.13, -172.0 64.67, 84.34 208.92, 83.41 -102.51, 37.37 294.94, 103.28 -69.92, -22.45 in-in in 8.602 Saltbr-in 2.803 HRD-in -64.72, -40.04 62.76, -16.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.1 APE8-dihe-in -84.86, 78.78 APE8-rot-na 27.08 APE67-dihe-in -69.19, -9.72 -53.68, -42.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.385 T790M,L858R,E865A,E866A,K867A None None XRAY 3.1 0.195 0.229 A 331 296 20 0 0 16 [[712, 970]] 1.0 4rj5 Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAQA P00533 697 1018 1210.0 4ZJ:1102 Type1.5_Back None DFGin 5.668 14.915 BLAminus DFGAsp-rot-in -137.02, -170.07 67.33, 79.05 213.24, -44.82 -91.72, 13.18 294.21, 102.26 -60.56, -10.03 in-in in 8.672 Saltbr-in 2.802 HRD-in -60.07, -52.9 72.53, 1.36 in-in-none SNCiin in-none ActLoopNT-in 2.794 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.08 APE8-dihe-in -79.35, 76.04 APE8-rot-na 30.69 APE67-dihe-in -65.52, -10.47 -45.15, -52.46 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.989 T790M,L858R,E865A,E866A,K867A None None XRAY 2.5 0.185 0.224 A 331 301 16 0 0 14 [[712, 970]] 1.0 5caq Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CASA P00533 696 1019 1210.0 4ZQ:1102 Type1.5_Back None DFGin 5.648 14.99 BLAminus DFGAsp-rot-in -138.57, -167.77 68.04, 80.06 206.64, -33.13 -91.6, 15.8 296.16, 107.26 -57.65, -21.97 in-in in 8.912 Saltbr-in 2.832 HRD-in -67.55, -52.18 71.84, 1.99 in-in-none SNCiin in-none ActLoopNT-in 2.788 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.6 APE8-dihe-in -82.22, 70.93 APE8-rot-na 30.15 APE67-dihe-in -66.03, -7.47 -43.73, -55.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.053 T790M,L858R,E865A,E866A,K867A None None XRAY 2.1 0.184 0.209 A 331 299 17 0 0 13 [[712, 970]] 1.0 5cas Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CAUA P00533 696 1018 1210.0 4ZR:1102 Type1.5_Back None DFGin 5.613 14.906 BLAminus DFGAsp-rot-in -141.53, -166.31 67.78, 77.4 210.44, -43.04 -89.35, 12.82 295.09, 107.73 -56.63, -14.57 in-in in 8.802 Saltbr-in 2.786 HRD-in -63.68, -54.38 71.77, 1.7 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.07 APE8-dihe-in -84.23, 76.34 APE8-rot-na 31.68 APE67-dihe-in -64.39, -7.38 -48.76, -54.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.158 T790M,L858R,E865A,E866A,K867A None None XRAY 2.25 0.188 0.211 A 331 297 18 0 0 14 [[712, 970]] 1.0 5cau Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HCYA P00533 696 1019 1210.0 60D:1102 Type1.5_Back None DFGin 5.564 14.343 BLAminus DFGAsp-rot-in -135.17, -165.75 65.93, 78.25 202.31, -25.32 -91.02, 13.27 295.4, 107.72 -55.11, -21.47 in-in in 8.422 Saltbr-in 2.796 HRD-in -60.52, -51.07 73.09, 1.44 in-in-none SNCiin in-none ActLoopNT-in 2.793 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.03 APE8-dihe-in -85.54, 71.02 APE8-rot-na 32.48 APE67-dihe-in -70.08, -5.63 -50.19, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.509 T790M,L858R,E865A,E866A,K867A None None XRAY 2.46 0.178 0.221 A 331 302 15 0 0 13 [[712, 970]] 1.0 5hcy Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5HICA P00533 697 1019 1210.0 63N:1102 Type1.5_Back None DFGin 5.647 14.297 BLAminus DFGAsp-rot-in -139.13, -164.08 62.52, 78.14 206.43, -34.52 -92.5, 16.36 295.34, 105.72 -61.37, -14.82 in-in in 8.313 Saltbr-in 3.06 HRD-in -60.28, -47.26 67.03, 5.82 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.05 APE8-dihe-in -87.68, 72.67 APE8-rot-na 27.72 APE67-dihe-in -63.88, -10.28 -48.63, -51.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.353 T790M,L858R,E865A,E866A,K867A None None XRAY 2.6 0.191 0.233 A 331 302 16 0 0 14 [[712, 970]] 1.0 5hic Homo sapiens TYR_EGFR_HUMAN TYR 4.8e-86 294.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 5I9VA P29317 605 896 976.0 AGS:1001 ATPlike None DFGin 5.797 14.921 BLAminus DFGAsp-rot-in -141.81, -171.65 57.06, 75.11 198.09, -10.46 -93.17, 20.3 299.55, 97.8 -61.14, -30.9 in-in in 8.619 Saltbr-in 2.822 HRD-in -77.85, -47.75 76.63, -12.15 in-in-none SNCiin in-none ActLoopNT-in 2.918 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 136.3 APE9-dihe-in -111.36, 131.85 APE8-dihe-in -64.26, 123.12 APE8-rot-na 332.19 APE67-dihe-in -77.38, -2.66 -54.41, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.712 APE9-dist-na 5.342 None None None XRAY 1.458 0.164 0.191 A 306 279 13 0 0 13 [[613, 873]] 1.0 5i9v Homo sapiens TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 1MQBB P29317 602 883 976.0 ANP:1001 ATPlike None DFGin 5.691 14.889 BLAminus DFGAsp-rot-in -139.65, -173.77 51.28, 81.33 200.75, -3.37 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.273 Saltbr-in 2.64 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.328 APE9-dist-na 6.633 None None None XRAY 2.3 0.237 0.288 B 333 265 17 0 0 13 [[613, 873]] 1.0 1mqb Homo sapiens TYR_EPHA2_HUMAN TYR 7.7e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 7KJAB P29317 590 965 976.0 ACP:61003 ATPlike None DFGin 5.95 15.319 BLAminus DFGAsp-rot-in -132.83, -173.32 70.39, 83.56 194.46, 9.79 -118.78, 24.56 302.85, 98.09 -89.22, 999.0 in-in in 8.607 Saltbr-in 3.165 HRD-in -76.56, -48.38 78.92, -16.95 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.75 APE8-rot-na 32.08 APE67-dihe-in -69.28, -11.58 -65.6, -29.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.75 0.19 0.217 B 390 349 22 0 0 20 [[613, 873]] 1.0 7kja Homo sapiens TYR_EPHA2_HUMAN TYR 1.3e-107 365.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5IA0A P29317 604 889 976.0 A5B:1001 Type1 None DFGin 5.75 15.225 BLAminus DFGAsp-rot-in -131.01, -155.76 61.65, 69.41 182.46, 57.88 -104.69, 91.97 299.22, 100.6 -172.83, 999.0 in-in in 7.988 Saltbr-in 3.057 HRD-in -80.45, -46.02 73.5, -13.13 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 103.13 APE8-dihe-in -95.39, 103.1 APE8-rot-na 22.72 APE67-dihe-in -72.64, -3.49 -61.44, -50.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.638 None None None XRAY 1.948 0.194 0.225 A 306 263 23 0 0 19 [[613, 873]] 1.0 5ia0 Homo sapiens TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5NKAA P29317 605 895 976.0 91H:1001 Type1 None DFGin 5.817 15.43 BLAminus DFGAsp-rot-in -138.05, -167.81 59.6, 76.5 218.06, -52.73 -90.38, 23.3 298.3, 92.95 -114.03, 999.0 in-in in 8.742 Saltbr-in 3.565 HRD-in -74.33, -47.29 74.19, -12.19 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -56.83 APE9-dihe-in -63.62, 121.18 APE8-dihe-in -54.7, 111.87 APE8-rot-na 330.09 APE67-dihe-in -75.86, -5.14 -47.88, -45.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.701 None None None XRAY 1.377 0.161 0.182 A 306 271 18 0 0 18 [[613, 873]] 1.0 5nka Homo sapiens TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 6FNHC P29317 600 890 976.0 DXK:1001 Type1 None DFGin 6.1 15.078 BLAminus DFGAsp-rot-in -136.98, -166.98 54.47, 77.28 196.09, -36.67 -106.75, 37.52 303.15, 87.48 -109.85, 171.74 in-in in 8.523 Saltbr-in 2.973 HRD-in -71.56, -48.37 75.35, -10.7 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 34.12 APE8-rot-na 34.55 APE67-dihe-in -53.44, -22.38 -49.0, -43.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.379 0.206 0.221 C 306 270 21 0 0 19 [[613, 873]] 1.0 6fnh Homo sapiens TYR_EPHA2_HUMAN TYR 5.7e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOQA P29320 595 906 983.0 ANP:948 ATPlike None DFGin 5.36 15.575 BLAminus DFGAsp-rot-in -132.4, -170.9 64.35, 72.55 182.94, 46.73 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.635 Saltbr-in 2.727 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.743 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373 285 18 0 0 18 [[621, 880]] 1.0 2qoq Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2GSFA P29320 595 904 983.0 No_ligand No_ligand None DFGin 5.349 15.927 BLAminus DFGAsp-rot-in -131.51, -172.61 60.33, 76.56 199.71, -17.47 -88.59, 16.43 293.13, 100.05 -68.35, -25.64 in-in in 8.866 Saltbr-in 2.652 HRD-in -71.12, -50.16 76.26, -12.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 86.12 APE8-rot-na 32.33 APE67-dihe-in -59.76, -26.04 -51.66, -46.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 A608T None None XRAY 1.77 0.16 0.195 A 373 281 16 0 0 16 [[621, 880]] 1.0 2gsf Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOKA P29320 595 904 983.0 No_ligand No_ligand None DFGin 5.347 15.982 BLAminus DFGAsp-rot-in -129.42, -174.51 59.36, 78.84 203.91, -30.91 -100.22, 55.36 291.83, 96.7 -103.96, -34.04 in-in in 8.81 Saltbr-in 2.76 HRD-in -71.78, -47.74 73.73, -11.15 in-in-none SNCiin in-none ActLoopNT-in 3.035 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 55.48 APE8-dihe-in -87.96, 87.99 APE8-rot-na 33.99 APE67-dihe-in -60.98, -24.84 -56.01, -43.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.629 Y596F,Y602F,S768A None None XRAY 1.2 0.192 0.212 A 373 281 15 0 0 15 [[621, 880]] 1.0 2qok Homo sapiens TYR_EPHA3_HUMAN TYR 1.2e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4GK3A P29320 609 903 983.0 L87:1001 Type1 None DFGin 5.139 14.807 BLAminus DFGAsp-rot-in -128.6, -167.12 48.3, 97.81 196.16, -22.72 -109.44, 24.03 294.5, 89.74 -59.07, -35.31 in-in in 8.501 Saltbr-in 2.722 HRD-in -73.64, -49.53 73.8, -7.65 in-in-none SNCiin in-none ActLoopNT-in 3.009 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.11 APE8-dihe-in -78.03, 100.04 APE8-rot-na 30.24 APE67-dihe-in -60.07, -23.79 -51.41, -46.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.718 None None None XRAY 1.898 0.18 0.213 A 361 275 14 0 0 14 [[621, 880]] 1.0 4gk3 Homo sapiens TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4P5QA P29320 609 904 983.0 Q0B:1001 Type1 None DFGin 5.364 15.215 BLAminus DFGAsp-rot-in -132.21, -177.08 65.28, 76.17 177.61, 38.05 -99.61, 30.73 291.45, 96.46 -83.91, -18.12 in-in in 8.287 Saltbr-in 3.266 HRD-in -71.43, -46.81 71.58, -8.33 in-in-none SNCiin in-none ActLoopNT-in 3.015 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.01 APE8-dihe-in -79.2, 95.75 APE8-rot-na 30.23 APE67-dihe-in -60.52, -25.3 -53.27, -46.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.974 None None None XRAY 1.35 0.158 0.182 A 361 275 16 0 0 16 [[621, 880]] 1.0 4p5q Homo sapiens TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4TWOA P29320 609 906 983.0 37W:1001 Type1 None DFGin 5.261 14.863 BLAminus DFGAsp-rot-in -137.23, -171.69 56.38, 84.7 201.36, -86.31 -101.99, 32.13 298.62, 95.53 -60.78, -52.61 in-in in 8.171 Saltbr-in 3.147 HRD-in -68.52, -51.72 76.5, -11.58 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 87.71 APE8-rot-na 30.54 APE67-dihe-in -57.89, -27.69 -50.33, -47.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.047 0.165 0.201 A 361 278 15 0 0 15 [[621, 880]] 1.0 4two Homo sapiens TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4G2FA P29320 609 903 983.0 C07:1001 Type1.5_Back None DFGin 5.45 14.73 BLAminus DFGAsp-rot-in -131.64, -174.37 59.7, 79.41 182.01, 50.07 -98.99, 31.81 296.97, 96.01 -73.91, -33.0 in-in in 8.217 Saltbr-in 2.799 HRD-in -73.48, -46.44 72.16, -6.7 in-in-none SNCiin in-none ActLoopNT-in 3.029 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 96.83 APE8-rot-na 28.88 APE67-dihe-in -63.99, -23.43 -56.19, -41.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.699 0.18 0.208 A 361 275 15 0 0 15 [[621, 880]] 1.0 4g2f Homo sapiens TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4GK2A P29320 609 903 983.0 L66:1001 Type1.5_Back None DFGin 5.393 14.345 BLAminus DFGAsp-rot-in -141.54, -172.14 65.23, 79.03 185.39, -84.84 -100.69, 30.27 304.12, 98.46 -69.06, -39.74 in-in in 7.956 Saltbr-in 2.511 HRD-in -70.13, -49.29 72.76, -10.27 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 71.91 APE8-rot-na 28.95 APE67-dihe-in -60.83, -25.11 -56.53, -45.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.195 0.193 0.236 A 361 265 19 0 0 19 [[621, 880]] 1.0 4gk2 Homo sapiens TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4GK4A P29320 609 903 983.0 L90:1001 Type1.5_Back None DFGin 5.006 14.462 BLAminus DFGAsp-rot-in -141.92, -169.06 54.42, 84.57 192.84, -13.37 -99.59, 22.26 304.42, 95.75 -54.8, -38.22 in-in in 8.552 Saltbr-in 3.151 HRD-in -68.01, -52.25 74.92, -3.22 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -110.32 APE9-dihe-in -98.4, 140.84 APE8-dihe-in -76.92, 99.05 APE8-rot-na 30.32 APE67-dihe-in -60.09, -27.75 -52.08, -44.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.922 APE9-dist-na 5.745 None None None XRAY 2.1 0.176 0.226 A 361 275 13 0 0 13 [[621, 880]] 1.0 4gk4 Homo sapiens TYR_EPHA3_HUMAN TYR 1e-110 375.2 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA7 EPHA7_HUMAN 7EEDA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 5.615 15.231 BLAminus DFGAsp-rot-in -160.14, -166.28 43.23, 89.72 202.64, -81.96 -111.48, -20.96 267.38, 102.35 -54.62, 166.76 in-in in 7.54 Saltbr-in 2.797 HRD-in -78.26, -42.61 76.57, -37.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.25 APE8-rot-na 338.3 APE67-dihe-in -74.18, -6.71 -44.02, -59.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D751H None None XRAY 3.05 0.201 0.247 A 304 275 18 0 0 18 [[633, 892]] 1.0 7eed Homo sapiens TYR_EPHA7_HUMAN TYR 2.4e-109 370.6 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
TYR EPHA7 EPHA7_HUMAN 2REIA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 5.726 14.648 BLAminus DFGAsp-rot-in -132.78, -176.46 70.06, 80.71 178.47, 48.35 -109.81, 15.52 296.72, 101.1 -73.37, 178.43 in-in in 7.787 Saltbr-in 2.792 HRD-in -77.06, -49.41 79.73, -27.49 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -43.44 APE8-rot-na 327.54 APE67-dihe-in -71.85, -8.27 -50.21, -50.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.6 0.164 0.187 A 318 274 19 0 0 19 [[633, 892]] 1.0 2rei Homo sapiens TYR_EPHA7_HUMAN TYR 2.1e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
TYR EPHA7 EPHA7_HUMAN 7EECA Q15375 607 899 998.0 No_ligand No_ligand None DFGin 4.921 14.381 BLAminus DFGAsp-rot-in -139.59, -159.42 45.62, 100.81 165.98, 66.24 -122.34, 29.16 288.48, 121.6 -110.62, -128.85 in-in in 7.604 Saltbr-in 3.2 HRD-in -65.62, -46.05 82.26, -52.23 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.96 APE8-rot-na 42.57 APE67-dihe-in -71.92, -1.3 -56.97, -50.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 G656R None None XRAY 3.1 0.183 0.21 A 305 274 19 0 0 19 [[633, 892]] 1.0 7eec Homo sapiens TYR_EPHA7_HUMAN TYR 2.1e-109 370.8 1 260 260 775 776 777 779 781 665 682 686 755 757 756 758 818 806 801 800 799 798 797 796 795 712 Ephrin type-A receptor 7
TYR EPHA8 EPHA8_HUMAN 3KULA P29322 627 900 1005.0 No_ligand No_ligand None DFGin 6.33 13.426 BLAminus DFGAsp-rot-in -132.25, 178.69 63.32, 84.46 202.12, -17.61 -103.71, 28.05 296.17, 106.15 -76.22, -31.33 in-in in 8.865 Saltbr-in 2.319 HRD-in -84.23, -53.19 81.45, -9.81 in-in-none SNCiin in-none ActLoopNT-in 2.881 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 148.1 APE8-dihe-in -72.66, 90.4 APE8-rot-na 22.79 APE67-dihe-in -74.46, -16.08 -47.23, -40.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.844 None None None XRAY 2.15 0.19 0.244 A 325 267 7 0 0 7 [[635, 894]] 1.0 3kul Homo sapiens TYR_EPHA8_HUMAN TYR 1.3e-102 348.6 1 260 260 777 778 779 781 783 667 684 688 757 759 758 760 820 808 803 802 801 800 799 798 797 714 Ephrin type-A receptor 8
TYR EPHB1 EPHB1_HUMAN 3ZFXB P54762 611 892 984.0 No_ligand No_ligand None DFGin 5.817 14.513 BLAminus DFGAsp-rot-in -140.84, 175.74 70.16, 66.52 225.27, -65.4 -88.36, 22.51 296.61, 82.06 -65.86, -37.4 in-in in 8.361 Saltbr-in 2.745 HRD-in -73.6, -53.87 82.61, -12.27 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -68.46, -4.35 999.0, -41.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 B 298 254 28 0 0 18 [[619, 880]] 1.0 3zfx Homo sapiens TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 3ZFXC P54762 614 892 984.0 No_ligand No_ligand None DFGin 5.738 14.561 BLAminus DFGAsp-rot-in -137.69, 173.75 69.1, 70.2 221.46, -51.65 -91.34, 24.03 296.14, 85.79 -69.43, -30.67 in-none in 8.387 Saltbr-none 999.0 HRD-in -72.86, -47.73 75.93, -10.98 none-in-none SNCnin in-none ActLoopNT-in 3.003 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 119.99 APE8-rot-na 23.72 APE67-dihe-in -76.29, 1.22 -135.32, -30.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 C 298 248 31 0 0 19 [[619, 880]] 1.0 3zfx Homo sapiens TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 3ZFXF P54762 612 893 984.0 No_ligand No_ligand None DFGin 5.751 14.45 BLAminus DFGAsp-rot-in -141.17, 174.54 70.47, 73.51 215.14, -60.33 -96.07, 25.2 298.87, 86.22 -68.13, -33.68 in-none in 8.262 Saltbr-none 999.0 HRD-in -76.22, -51.77 80.7, -11.45 none-in-none SNCnin in-none ActLoopNT-in 2.908 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -75.22, -1.35 999.0, -38.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 F 298 254 28 0 0 18 [[619, 880]] 1.0 3zfx Homo sapiens TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 3ZFXG P54762 611 892 984.0 No_ligand No_ligand None DFGin 5.718 14.52 BLAminus DFGAsp-rot-in -137.41, 174.48 70.94, 70.55 222.75, -46.96 -95.84, 25.71 297.3, 82.59 -71.73, -27.91 in-in in 8.36 Saltbr-in 2.761 HRD-in -75.32, -55.18 83.83, -8.92 in-in-none SNCiin in-none ActLoopNT-in 2.97 ActLoopCT-none TYR APEdihe_nnnan APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-na 999.0 APE67-dihe-none -75.69, 3.79 999.0, -41.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.5 0.19 0.217 G 298 253 29 0 0 18 [[619, 880]] 1.0 3zfx Homo sapiens TYR_EPHB1_HUMAN TYR 3e-109 370.3 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB1 EPHB1_HUMAN 5MJAA P54762 609 892 984.0 7O3:901 Type1.5_Back None DFGin 5.88 13.902 BLAminus DFGAsp-rot-in -139.99, -175.99 56.55, 73.99 214.91, -63.63 -90.49, 10.93 298.25, 99.95 -50.92, -47.24 in-in in 7.881 Saltbr-in 2.793 HRD-in -76.83, -50.44 72.7, -6.85 in-in-none SNCiin in-none ActLoopNT-in 2.864 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 37.53 APE8-rot-na 25.39 APE67-dihe-in -70.7, -7.58 -41.98, -56.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR647,PTR778 PTR647,PTR778 XRAY 2.14 0.202 0.236 A 305 273 11 0 0 11 [[619, 880]] 1.0 5mja Homo sapiens TYR_EPHB1_HUMAN TYR 5.5e-109 369.5 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR EPHB4 EPHB4_HUMAN 6FNLA P54760 607 888 987.0 No_ligand No_ligand None DFGin 5.878 15.674 BLAminus DFGAsp-rot-in -131.81, -173.59 71.94, 76.75 186.39, 27.63 -109.07, -10.52 295.76, 100.61 -115.48, 999.0 in-in in 8.17 Saltbr-in 3.201 HRD-in -75.8, -47.92 75.96, -12.97 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 41.74 APE9-dihe-in -75.1, 127.77 APE8-dihe-in -74.57, 87.67 APE8-rot-na 29.53 APE67-dihe-in -73.26, -6.87 -55.8, -49.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.634 Y774E,A803V,V870I None None XRAY 1.269 0.197 0.213 A 297 262 20 0 0 20 [[615, 876]] 1.0 6fnl Homo sapiens TYR_EPHB4_HUMAN TYR 4.4e-105 356.7 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWA P54760 609 888 987.0 STU:1889 Type1 None DFGin 6.122 14.359 BLAminus DFGAsp-rot-in -139.16, 174.72 57.83, 79.91 208.66, 1.0 -97.95, 22.7 299.52, 94.02 -63.4, -45.19 in-in in 8.066 Saltbr-in 2.796 HRD-in -71.2, -51.67 69.26, -8.65 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 56.2 APE9-dihe-in -113.28, 124.67 APE8-dihe-in -75.39, 88.73 APE8-rot-na 23.8 APE67-dihe-in -74.18, -2.68 -39.84, -58.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.292 APE9-dist-na 6.071 None PTR774 PTR774 XRAY 2.5 0.24 0.282 A 298 270 10 0 0 6 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.7e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR EPHB4 EPHB4_HUMAN 3ZEWB P54760 609 887 987.0 STU:1888 Type1 None DFGin 6.6 14.69 BLAminus DFGAsp-rot-in -136.46, 179.33 65.25, 57.03 196.98, -0.09 -88.32, 123.85 306.76, 101.31 132.26, 999.0 in-none in 7.638 Saltbr-none 999.0 HRD-in -68.01, -45.09 76.33, -22.89 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 147.88 APE8-dihe-in -93.06, 95.29 APE8-rot-na 27.85 APE67-dihe-in -68.25, -2.97 -47.06, -56.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.554 None PTR774 PTR774 XRAY 2.5 0.24 0.282 B 298 252 27 0 0 21 [[615, 876]] 1.0 3zew Homo sapiens TYR_EPHB4_HUMAN TYR 2.7e-104 354.1 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FES FES_HUMAN 4E93A P07332 448 822 822.0 GUI:60901 Type1 None DFGin 7.239 15.206 BLAminus DFGAsp-rot-in -147.07, -173.8 68.79, 70.92 213.96, 0.15 -92.31, 15.15 286.08, 92.67 -61.32, -36.23 in-in in 8.156 Saltbr-in 2.815 HRD-in -75.42, -47.46 72.8, -15.51 in-in-none SNCiin in-none ActLoopNT-in 2.899 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -46.55 APE8-dihe-in -81.8, 74.32 APE8-rot-na 28.54 APE67-dihe-in -65.5, -10.65 -48.91, -48.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.576 None None None XRAY 1.84 0.189 0.238 A 377 359 14 0 0 14 [[561, 816]] 1.0 4e93 Homo sapiens TYR_FES_HUMAN TYR 6.8e-94 320.0 1 260 260 700 701 702 704 706 590 607 611 680 682 681 683 742 730 725 724 723 722 721 720 719 637 Tyrosine-protein kinase Fes/Fps
TYR IGF1R IGF1R_HUMAN 3LVPD P08069 986 1285 1367.0 PDR:4 Type1 None DFGin 6.306 14.427 BLAminus DFGAsp-rot-in -106.91, 166.93 53.44, 123.0 177.8, -70.73 -131.84, 26.68 301.24, 78.21 -46.25, -39.95 in-in in 9.275 Saltbr-in 3.129 HRD-in -65.98, -38.21 59.59, -1.0 in-in-none SNCiin in-none ActLoopNT-in 2.829 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 78.94 APE8-dihe-in -74.27, 72.81 APE8-rot-na 31.79 APE67-dihe-in -58.26, -9.17 -42.05, -56.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.259 None None None XRAY 3.0 0.226 0.279 D 336 282 18 0 0 3 [[999, 1268]] 1.0 3lvp Homo sapiens TYR_IGF1R_HUMAN TYR 2.7e-95 324.6 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR ITK ITK_HUMAN 3QGYB Q08881 357 616 620.0 L7O:60001 Type1 None DFGin 6.848 14.057 BLAminus DFGAsp-rot-in -138.24, -166.58 61.2, 71.7 209.66, -57.09 -99.64, 31.78 306.13, 96.16 -71.38, 20.95 in-in in 8.191 Saltbr-in 2.851 HRD-in -62.69, -53.89 75.14, -0.93 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 61.56 APE8-rot-na 999.0 APE67-dihe-in -67.28, -16.11 -66.33, -15.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.208 0.247 B 286 244 16 0 0 16 [[363, 614]] 1.0 3qgy Homo sapiens TYR_ITK_HUMAN TYR 1.4e-92 315.7 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK2-2 JAK2_HUMAN 4D1SA O60674 842 1130 1132.0 BJG:1141 Type1 None DFGin 6.153 14.03 BLAminus DFGAsp-rot-in -124.84, -163.04 46.78, 76.68 203.66, -23.61 -90.28, 22.64 295.97, 91.18 -59.77, -25.09 in-in in 8.462 Saltbr-in 2.749 HRD-in -72.78, -44.48 72.51, -0.35 in-in-none SNCiin in-none ActLoopNT-in 2.776 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.85 APE8-dihe-in -79.29, 70.09 APE8-rot-na 33.83 APE67-dihe-in -78.27, -2.32 -57.11, -28.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.736 None PTR1007,PTR1008 PTR1007,PTR1008 XRAY 1.66 0.205 0.231 A 298 282 7 0 0 5 [[545, 807], [849, 1125]] 2.0 4d1s Homo sapiens TYR_JAK2-2_HUMAN TYR 2.6e-87 298.4 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5USYA O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.298 14.188 BLAminus DFGAsp-rot-in -130.23, -164.34 47.33, 79.32 181.61, 40.22 -93.1, 20.71 291.84, 98.58 -62.97, -21.55 in-in in 8.613 Saltbr-in 2.803 HRD-in -71.47, -46.11 68.35, -0.6 in-in-none SNCiin in-none ActLoopNT-in 2.735 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.57 APE8-dihe-in -78.81, 76.11 APE8-rot-na 30.98 APE67-dihe-in -83.0, 0.49 -61.55, -24.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.265 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 A 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy Homo sapiens TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK2-2 JAK2_HUMAN 5USYB O60674 840 1130 1132.0 SKE:1201 Type1 None DFGin 6.309 14.253 BLAminus DFGAsp-rot-in -121.96, -156.65 31.13, 87.35 219.52, -45.37 -93.3, 22.45 292.93, 84.2 -66.48, -18.97 in-in in 8.443 Saltbr-in 2.973 HRD-in -70.92, -45.61 67.52, 2.98 in-in-none SNCiin in-none ActLoopNT-in 2.725 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.82 APE8-dihe-in -82.14, 78.44 APE8-rot-na 33.08 APE67-dihe-in -81.92, -0.91 -60.29, -26.19 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.406 None PTR1007 PTR1007 XRAY 2.0 0.178 0.216 B 316 288 3 0 0 3 [[545, 807], [849, 1125]] 2.0 5usy Homo sapiens TYR_JAK2-2_HUMAN TYR 3.3e-87 298.1 1 260 260 993 994 995 997 999 882 898 902 973 975 974 976 1036 1024 1019 1018 1017 1016 1015 1014 1013 930 Tyrosine-protein kinase JAK2
TYR JAK3-2 JAK3_HUMAN 6HZVA P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.429 14.257 BLAminus DFGAsp-rot-in -133.87, 178.6 61.51, 90.4 201.64, -2.64 -109.85, 28.17 289.99, 77.52 -67.6, -31.52 in-in in 8.324 Saltbr-in 2.931 HRD-in -62.66, -43.13 71.32, -8.68 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 119.68 APE8-rot-na 14.07 APE67-dihe-in -79.55, -1.3 -80.03, -13.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 A 285 266 18 0 0 5 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6HZVB P52333 815 1099 1124.0 GYW:1101 Type1 None DFGin 6.194 14.214 BLAminus DFGAsp-rot-in -135.38, 176.48 64.47, 86.88 197.48, -16.4 -105.43, 20.89 286.69, 85.17 -66.35, -29.51 in-in in 8.149 Saltbr-in 2.826 HRD-in -61.18, -44.44 71.7, 4.93 in-in-none SNCiin in-none ActLoopNT-in 2.691 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 129.11 APE8-rot-na 330.57 APE67-dihe-in -79.98, -2.63 -77.74, -18.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 B 285 269 16 0 0 6 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6HZVC P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.477 14.272 BLAminus DFGAsp-rot-in -130.86, 179.06 58.44, 90.28 202.3, -19.99 -109.09, 23.07 290.05, 84.12 -62.59, -33.96 in-in in 8.091 Saltbr-in 2.809 HRD-in -69.82, -48.24 78.15, -8.29 in-in-none SNCiin in-none ActLoopNT-in 2.689 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -41.25 APE8-dihe-in -66.72, 131.5 APE8-rot-na 341.69 APE67-dihe-in -75.5, -7.29 -73.63, -18.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.346 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 C 285 265 19 0 0 5 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6HZVD P52333 815 1098 1124.0 GYW:1101 Type1 None DFGin 6.418 14.152 BLAminus DFGAsp-rot-in -133.07, -178.12 58.66, 85.08 198.36, -19.73 -104.02, 25.84 292.67, 81.24 -61.98, -32.78 in-in in 8.14 Saltbr-in 2.77 HRD-in -71.74, -43.92 75.22, -14.51 in-in-none SNCiin in-none ActLoopNT-in 2.708 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -35.5 APE8-dihe-in -66.27, 131.93 APE8-rot-na 340.52 APE67-dihe-in -79.97, 1.1 -77.2, -17.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.634 None PTR980,PTR981 PTR980,PTR981 XRAY 2.46 0.224 0.275 D 285 259 25 0 0 5 [[521, 779], [822, 1097]] 2.0 6hzv Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86A P52333 814 1098 1124.0 9YV:4000 Type1 None DFGin 6.508 14.233 BLAminus DFGAsp-rot-in -130.78, -178.04 55.33, 86.29 180.24, 75.51 -99.45, 24.99 285.64, 80.91 -59.45, -36.09 in-in in 8.361 Saltbr-in 2.72 HRD-in -61.74, -49.91 79.02, -19.05 in-in-none SNCiin in-none ActLoopNT-in 2.834 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -62.63 APE8-dihe-in -73.09, 69.06 APE8-rot-na 28.5 APE67-dihe-in -76.22, -6.14 -68.16, -24.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.326 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 A 287 271 14 0 0 5 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86B P52333 816 1098 1124.0 9YV:4000 Type1 None DFGin 6.572 14.126 BLAminus DFGAsp-rot-in -130.89, -177.7 55.33, 86.59 179.18, 76.38 -98.74, 23.53 285.65, 80.73 -58.36, -36.34 in-in in 8.175 Saltbr-in 2.781 HRD-in -61.09, -43.56 75.39, -22.05 in-in-none SNCiin in-none ActLoopNT-in 2.827 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-in -98.06, 144.28 APE8-rot-na 28.22 APE67-dihe-in -84.46, -5.87 -122.29, -17.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.756 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 B 287 269 14 0 0 5 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86C P52333 814 1099 1124.0 9YV:4000 Type1 None DFGin 6.507 14.111 BLAminus DFGAsp-rot-in -131.5, -178.51 55.57, 86.1 179.55, 76.28 -97.59, 23.31 285.7, 80.13 -57.67, -36.43 in-in in 8.165 Saltbr-in 2.94 HRD-in -62.63, -48.44 77.31, -20.33 in-in-none SNCiin in-none ActLoopNT-in 2.822 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -67.29 APE8-rot-na 15.79 APE67-dihe-in -70.13, -18.29 -58.03, -20.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 C 287 275 11 0 0 6 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5W86D P52333 814 1099 1124.0 9YV:4000 Type1 None DFGin 6.561 14.255 BLAminus DFGAsp-rot-in -130.88, -178.77 56.18, 85.97 180.61, 75.87 -99.02, 25.19 285.73, 80.24 -59.91, -34.36 in-in in 8.183 Saltbr-in 2.757 HRD-in -62.59, -49.55 78.85, -19.41 in-in-none SNCiin in-none ActLoopNT-in 2.814 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -64.08 APE8-dihe-in -73.59, 57.74 APE8-rot-na 27.09 APE67-dihe-in -73.08, -10.82 -59.31, -28.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.241 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.61 0.211 0.264 D 287 274 12 0 0 5 [[521, 779], [822, 1097]] 2.0 5w86 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6AAKD P52333 814 1098 1124.0 9T6:1201 Type1 None DFGin 6.331 14.138 BLAminus DFGAsp-rot-in -145.03, 168.99 56.55, 97.11 206.83, -32.59 -103.75, 32.24 293.47, 81.71 -62.01, -33.71 in-in in 8.018 Saltbr-in 2.856 HRD-in -76.49, -42.81 76.74, -36.27 in-in-none SNCiin in-none ActLoopNT-in 2.766 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 72.65 APE8-dihe-in -50.29, 134.06 APE8-rot-na 332.19 APE67-dihe-in -63.85, -16.03 -70.13, -20.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.384 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.67 0.269 0.326 D 287 268 17 0 0 5 [[521, 779], [822, 1097]] 2.0 6aak Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZC6B P52333 813 1100 1124.0 VFC:2103 Type1 None DFGin 6.218 14.046 BLAminus DFGAsp-rot-in -128.88, -176.96 59.69, 81.97 196.63, 0.21 -99.61, 22.0 289.18, 82.46 -63.53, -20.72 in-in in 8.209 Saltbr-in 2.799 HRD-in -71.31, -49.71 79.31, 3.34 in-in-none SNCiin in-none ActLoopNT-in 2.748 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 25.15 APE9-dihe-in -99.95, 171.81 APE8-dihe-in -50.02, 112.29 APE8-rot-na 325.04 APE67-dihe-in -73.29, -4.3 -58.87, -25.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.482 APE9-dist-na 6.84 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 B 288 278 10 0 0 4 [[521, 779], [822, 1097]] 2.0 3zc6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZC6C P52333 814 1100 1124.0 VFC:2103 Type1 None DFGin 6.281 14.003 BLAminus DFGAsp-rot-in -123.64, -177.74 61.16, 80.91 190.44, 6.73 -97.9, 27.04 288.23, 77.53 -66.72, -26.1 in-in in 8.191 Saltbr-in 2.684 HRD-in -72.21, -46.31 77.05, -24.4 in-in-none SNCiin in-none ActLoopNT-in 2.761 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -54.85 APE8-dihe-in -77.18, 80.1 APE8-rot-na 33.09 APE67-dihe-in -76.9, -10.93 -67.13, -29.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.177 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 C 288 277 10 0 0 4 [[521, 779], [822, 1097]] 2.0 3zc6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZC6D P52333 814 1100 1124.0 VFC:2103 Type1 None DFGin 6.315 14.132 BLAminus DFGAsp-rot-in -134.59, -176.68 59.2, 81.95 187.75, 9.76 -97.58, 24.75 285.45, 76.49 -66.73, -25.04 in-in in 8.057 Saltbr-in 2.742 HRD-in -74.86, -52.02 77.99, -12.75 in-in-none SNCiin in-none ActLoopNT-in 2.73 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.2 APE8-rot-na 32.25 APE67-dihe-in -80.63, -5.09 -78.85, -21.32 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.42 0.193 0.254 D 288 269 18 0 0 5 [[521, 779], [822, 1097]] 2.0 3zc6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZEPB P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.353 14.222 BLAminus DFGAsp-rot-in -142.2, 177.46 62.39, 84.45 191.4, 16.92 -101.38, 32.38 292.96, 77.07 -73.1, -37.75 in-in in 8.241 Saltbr-in 2.735 HRD-in -71.3, -45.86 73.98, -5.89 in-in-none SNCiin in-none ActLoopNT-in 2.769 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 174.81 APE8-dihe-in -59.17, 141.04 APE8-rot-na 332.8 APE67-dihe-in -80.76, -5.98 -67.68, -15.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.477 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 B 288 270 17 0 0 4 [[521, 779], [822, 1097]] 2.0 3zep Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZEPC P52333 814 1100 1124.0 1NX:2101 Type1 None DFGin 6.267 14.284 BLAminus DFGAsp-rot-in -143.3, 179.56 63.59, 86.35 197.11, -5.24 -106.32, 31.56 290.45, 75.82 -68.82, -32.0 in-in in 8.174 Saltbr-in 2.755 HRD-in -76.43, -48.0 76.34, -21.16 in-in-none SNCiin in-none ActLoopNT-in 2.714 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 45.01 APE9-dihe-in -93.38, 161.79 APE8-dihe-in -56.5, 116.98 APE8-rot-na 326.42 APE67-dihe-in -74.98, -4.7 -72.25, -13.12 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.729 APE9-dist-na 6.85 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 C 288 278 9 0 0 2 [[521, 779], [822, 1097]] 2.0 3zep Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 3ZEPD P52333 814 1099 1124.0 1NX:2100 Type1 None DFGin 6.575 14.572 BLAminus DFGAsp-rot-in -134.12, 176.57 59.25, 80.73 193.6, 18.77 -100.38, 28.57 291.24, 76.13 -63.83, -42.01 in-in in 8.361 Saltbr-in 2.672 HRD-in -72.39, -47.07 79.2, -13.88 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 161.47 APE8-dihe-in -52.69, 138.76 APE8-rot-na 329.47 APE67-dihe-in -77.9, -7.22 -77.25, -13.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.556 C1040S,C1048S PTR980,PTR981 PTR980,PTR981 XRAY 2.35 0.226 0.265 D 288 274 12 0 0 3 [[521, 779], [822, 1097]] 2.0 3zep Homo sapiens TYR_JAK3-2_HUMAN TYR 2e-81 279.1 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 7UYVD P52333 814 1100 1124.0 OV5:1201 Type1 None DFGin 6.421 14.258 BLAminus DFGAsp-rot-in -133.29, -179.06 58.4, 83.86 197.68, -4.58 -99.71, 22.65 285.23, 81.71 -62.49, -28.09 in-in in 8.298 Saltbr-in 2.672 HRD-in -64.99, -48.29 76.96, -0.25 in-in-none SNCiin in-none ActLoopNT-in 2.746 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 163.98 APE8-dihe-in -58.27, 129.89 APE8-rot-na 335.93 APE67-dihe-in -80.69, -3.3 -71.81, -12.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.468 None PTR980,PTR981 PTR980,PTR981 XRAY 2.15 0.222 0.263 D 291 272 15 0 0 5 [[521, 779], [822, 1097]] 2.0 7uyv Homo sapiens TYR_JAK3-2_HUMAN TYR 2.1e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 5VO6A P52333 815 1099 1124.0 9J4:4000 Type1 None DFGin 6.559 13.748 BLAminus DFGAsp-rot-in -128.78, -173.97 61.05, 89.09 187.1, 11.21 -107.4, 19.66 285.17, 86.8 -68.24, -28.8 in-in in 7.512 Saltbr-in 2.911 HRD-in -75.3, -50.06 76.72, -16.95 in-in-none SNCiin in-none ActLoopNT-in 2.982 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 135.66 APE8-rot-na 332.57 APE67-dihe-in -81.44, -5.82 -70.82, -9.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C1040S,C1048S None None XRAY 2.65 0.215 0.284 A 293 271 14 0 0 6 [[521, 779], [822, 1097]] 2.0 5vo6 Homo sapiens TYR_JAK3-2_HUMAN TYR 2.2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6NY4A P52333 815 1099 1124.0 Z3A:4000 Type1 None DFGin 6.432 13.752 BLAminus DFGAsp-rot-in -130.0, -166.41 50.15, 85.44 190.23, 14.44 -100.28, 21.12 284.91, 84.56 -64.41, -23.36 in-in in 7.69 Saltbr-in 2.777 HRD-in -74.4, -47.07 70.71, -6.14 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -0.08 APE9-dihe-in -95.23, 160.07 APE8-dihe-in -49.81, 129.43 APE8-rot-na 333.86 APE67-dihe-in -73.45, 2.08 -64.08, -16.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.706 APE9-dist-na 7.095 C811S,C1040S,C1048S None None XRAY 2.33 0.216 0.241 A 293 277 8 0 0 4 [[521, 779], [822, 1097]] 2.0 6ny4 Homo sapiens TYR_JAK3-2_HUMAN TYR 2.2e-81 279.0 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4V0GB P52333 816 1098 1124.0 G9B:2099 Type1 None DFGin 6.202 14.633 BLAminus DFGAsp-rot-in -137.8, -174.69 52.03, 76.68 199.98, -45.81 -96.09, 37.57 296.46, 78.81 -70.34, -40.16 in-in in 8.7 Saltbr-in 2.629 HRD-in -75.76, -37.0 67.95, -17.09 in-in-none SNCiin in-none ActLoopNT-in 2.824 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -54.69 APE8-rot-na 331.57 APE67-dihe-in -77.98, -0.68 -62.56, -42.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 B 283 274 9 0 0 5 [[521, 779], [822, 1097]] 2.0 4v0g Homo sapiens TYR_JAK3-2_HUMAN TYR 2.4e-81 278.9 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4V0GA P52333 817 1098 1124.0 G9B:2099 Type1 None DFGin 6.198 14.717 BLAminus DFGAsp-rot-in -144.75, -176.45 39.25, 85.88 184.86, 64.91 -90.52, 22.25 286.27, 74.42 -61.38, -18.98 in-in in 8.352 Saltbr-in 2.707 HRD-in -65.46, -44.14 69.1, 4.41 in-in-none SNCiin in-none ActLoopNT-in 2.85 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -33.75 APE8-rot-na 330.77 APE67-dihe-in -73.45, -1.83 -68.02, -39.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 3.0 0.254 0.295 A 283 269 13 0 0 4 [[521, 779], [822, 1097]] 2.0 4v0g Homo sapiens TYR_JAK3-2_HUMAN TYR 2.4e-81 278.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4Z16A P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.693 14.535 BLAminus DFGAsp-rot-in -125.11, -170.67 46.31, 83.09 186.88, 60.08 -100.98, 26.25 290.17, 83.28 -67.99, -29.42 in-in in 8.347 Saltbr-in 2.834 HRD-in -67.29, -45.59 73.41, -19.17 in-in-none SNCiin in-none ActLoopNT-in 2.829 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 77.57 APE8-rot-na 328.09 APE67-dihe-in -74.64, -13.67 -80.93, -12.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 A 316 273 17 0 0 5 [[521, 779], [822, 1097]] 2.0 4z16 Homo sapiens TYR_JAK3-2_HUMAN TYR 7.7e-81 277.2 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4Z16C P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.724 14.541 BLAminus DFGAsp-rot-in -124.89, -171.04 46.95, 83.36 186.69, 60.11 -101.0, 25.74 290.21, 83.17 -68.15, -28.94 in-in in 8.372 Saltbr-in 2.84 HRD-in -67.03, -45.78 73.53, -19.66 in-in-none SNCiin in-none ActLoopNT-in 2.788 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 38.92 APE8-rot-na 335.43 APE67-dihe-in -76.63, -13.6 -68.45, -18.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 C 316 273 17 0 0 5 [[521, 779], [822, 1097]] 2.0 4z16 Homo sapiens TYR_JAK3-2_HUMAN TYR 7.7e-81 277.2 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4Z16D P52333 814 1103 1124.0 4LH:2000 Type1 None DFGin 6.688 14.567 BLAminus DFGAsp-rot-in -124.04, -170.5 45.94, 82.68 187.13, 61.58 -99.35, 24.89 290.17, 82.54 -66.47, -27.42 in-in in 8.393 Saltbr-in 2.875 HRD-in -67.23, -45.45 73.09, -20.62 in-in-none SNCiin in-none ActLoopNT-in 2.794 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 52.48 APE8-rot-na 345.61 APE67-dihe-in -77.91, -13.97 -72.79, -6.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None PTR980,PTR981 PTR980,PTR981 XRAY 2.9 0.204 0.24 D 316 273 17 0 0 5 [[521, 779], [822, 1097]] 2.0 4z16 Homo sapiens TYR_JAK3-2_HUMAN TYR 7.7e-81 277.2 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4QPSA P52333 814 1100 1124.0 37Q:1201 Type1 None DFGin 6.896 14.091 BLAminus DFGAsp-rot-in -130.94, -174.49 64.52, 86.82 194.65, 2.33 -104.86, 15.71 281.27, 81.21 -57.28, -32.23 in-in in 8.588 Saltbr-in 2.864 HRD-in -78.56, -46.33 74.55, -53.21 in-in-none SNCiin in-none ActLoopNT-in 2.801 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 149.07 APE8-rot-na 18.94 APE67-dihe-in -69.31, -9.6 -100.11, -5.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 A 293 270 17 0 0 6 [[521, 779], [822, 1097]] 2.0 4qps Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 4QPSC P52333 814 1102 1124.0 37Q:1201 Type1 None DFGin 6.775 14.2 BLAminus DFGAsp-rot-in -137.32, -176.14 60.46, 91.64 189.65, 10.8 -108.44, 19.09 284.35, 76.96 -56.92, -26.19 in-in in 8.502 Saltbr-in 2.803 HRD-in -82.86, -44.58 73.92, -46.68 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.79 APE8-dihe-in -74.25, 110.88 APE8-rot-na 352.69 APE67-dihe-in -70.61, -6.19 -68.78, -23.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.991 D949A,C1040S,C1048S None None XRAY 1.8 0.21 0.251 C 293 276 13 0 0 5 [[521, 779], [822, 1097]] 2.0 4qps Homo sapiens TYR_JAK3-2_HUMAN TYR 4e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLAA P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.125 14.066 BLAminus DFGAsp-rot-in -126.69, -163.69 45.61, 84.37 192.89, 5.66 -97.16, 18.74 276.14, 73.33 -60.39, -30.05 in-in in 7.833 Saltbr-in 2.674 HRD-in -80.36, -50.35 74.06, -4.7 in-in-none SNCiin in-none ActLoopNT-in 2.749 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 115.39 APE9-dihe-in -100.65, 143.31 APE8-dihe-in -75.22, 92.35 APE8-rot-na 30.49 APE67-dihe-in -81.25, -0.82 -60.88, -31.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.679 APE9-dist-na 7.001 None None None XRAY 1.92 0.228 0.273 A 294 288 3 0 0 3 [[521, 779], [822, 1097]] 2.0 6gla Homo sapiens TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLAB P52333 813 1103 1124.0 F4B:1201 Type1 None DFGin 6.135 14.037 BLAminus DFGAsp-rot-in -126.98, -166.17 47.87, 84.06 194.36, 7.9 -100.26, 19.16 275.64, 73.52 -60.46, -30.51 in-in in 7.831 Saltbr-in 2.67 HRD-in -83.39, -49.56 74.28, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.775 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 114.52 APE9-dihe-in -101.31, 145.02 APE8-dihe-in -77.95, 91.55 APE8-rot-na 29.11 APE67-dihe-in -79.72, -1.04 -62.76, -29.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.745 APE9-dist-na 6.966 None None None XRAY 1.92 0.228 0.273 B 294 286 5 0 0 3 [[521, 779], [822, 1097]] 2.0 6gla Homo sapiens TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLBA P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.087 14.005 BLAminus DFGAsp-rot-in -127.29, -165.11 42.2, 80.94 195.48, 4.55 -98.99, 18.18 281.6, 72.22 -46.91, -40.63 in-in in 7.576 Saltbr-in 2.712 HRD-in -78.7, -52.76 77.75, 9.6 in-in-none SNCiin in-none ActLoopNT-in 2.734 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 129.22 APE9-dihe-in -106.96, 151.72 APE8-dihe-in -79.63, 91.52 APE8-rot-na 32.17 APE67-dihe-in -74.91, -5.23 -62.01, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.734 APE9-dist-na 6.727 None None None XRAY 2.0 0.236 0.29 A 294 288 3 0 0 3 [[521, 779], [822, 1097]] 2.0 6glb Homo sapiens TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 6GLBB P52333 813 1103 1124.0 F48:1201 Type1 None DFGin 6.117 14.025 BLAminus DFGAsp-rot-in -125.81, -165.95 42.86, 80.87 197.67, 1.05 -97.87, 18.6 282.22, 74.99 -51.1, -37.8 in-in in 7.545 Saltbr-in 2.708 HRD-in -76.97, -51.62 77.21, 8.56 in-in-none SNCiin in-none ActLoopNT-in 2.757 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 130.97 APE9-dihe-in -105.16, 150.45 APE8-dihe-in -79.13, 89.35 APE8-rot-na 33.14 APE67-dihe-in -76.14, -3.82 -57.76, -35.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.629 APE9-dist-na 6.704 None None None XRAY 2.0 0.236 0.29 B 294 288 3 0 0 3 [[521, 779], [822, 1097]] 2.0 6glb Homo sapiens TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 9R5ZA P52333 822 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.132 14.001 BLAminus DFGAsp-rot-in -127.52, -161.85 48.17, 81.61 188.21, 1.17 -92.0, 24.85 277.91, 73.75 -73.44, -23.7 in-in in 7.668 Saltbr-in 2.768 HRD-in -79.16, -47.46 79.61, -35.13 in-in-none SNCiin in-none ActLoopNT-in 2.88 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.63 APE8-rot-na 20.77 APE67-dihe-in -76.47, -3.83 -62.4, -34.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.8 0.239 0.289 A 294 258 22 0 0 5 [[521, 779], [822, 1097]] 2.0 9r5z Homo sapiens TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR JAK3-2 JAK3_HUMAN 9R5ZB P52333 816 1101 1124.0 A1JJU:60301 Type1 None DFGin 6.226 14.13 BLAminus DFGAsp-rot-in -127.35, -164.41 49.32, 77.12 194.05, 3.35 -91.09, 23.07 281.2, 72.28 -62.52, -23.26 in-in in 7.882 Saltbr-in 2.819 HRD-in -86.18, -46.89 79.27, -42.6 in-in-none SNCiin in-none ActLoopNT-in 2.875 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 79.25 APE8-rot-na 31.77 APE67-dihe-in -82.31, -0.99 -65.94, -24.16 APE12-dist-na 11.045 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 1.8 0.239 0.289 B 294 275 11 0 0 3 [[521, 779], [822, 1097]] 2.0 9r5z Homo sapiens TYR_JAK3-2_HUMAN TYR 4.1e-80 274.8 1 260 260 966 967 968 970 972 855 871 875 946 948 947 949 1009 997 992 991 990 989 988 987 986 903 Tyrosine-protein kinase JAK3
TYR KIT KIT_HUMAN 1PKGB P10721 566 929 976.0 ADP:1486 ATPlike None DFGin 6.537 13.819 BLAminus DFGAsp-rot-in -133.94, -165.75 57.9, 93.59 198.24, -19.36 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.934 Saltbr-in 2.915 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.888 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.765 APE9-dist-na 6.494 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329 279 27 0 0 13 [[589, 926]] 1.0 1pkg Homo sapiens TYR_KIT_HUMAN TYR 4.6e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8PQBA P10721 567 931 976.0 9XO:61001 Type1 None DFGin 7.065 13.907 BLAminus DFGAsp-rot-in -125.03, 178.92 57.85, 86.74 200.5, -26.57 -99.85, 27.47 283.64, 67.72 -68.32, -23.51 in-in in 7.946 Saltbr-in 2.834 HRD-in -88.64, -44.33 73.75, -0.94 in-in-none SNCiin in-none ActLoopNT-in 2.88 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -36.37 APE9-dihe-in -123.05, 142.81 APE8-dihe-in -78.63, 73.9 APE8-rot-na 33.79 APE67-dihe-in -70.48, -9.16 -54.85, -42.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.094 APE9-dist-na 7.446 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 1.87 0.2 0.234 A 327 270 17 0 0 11 [[589, 926]] 1.0 8pqb Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8PQEB P10721 566 930 976.0 9WU:61001 Type1 None DFGin 7.234 14.115 BLAminus DFGAsp-rot-in -126.18, 173.65 61.69, 86.72 202.25, -9.26 -98.88, 21.32 288.15, 71.07 -45.22, -42.17 in-in in 8.62 Saltbr-in 3.312 HRD-in -77.31, -50.57 76.99, -5.36 in-in-none SNCiin in-none ActLoopNT-in 2.779 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 124.75 APE9-dihe-in -123.1, 151.69 APE8-dihe-in -82.48, 77.97 APE8-rot-na 31.45 APE67-dihe-in -69.72, -10.62 -57.01, -43.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.159 APE9-dist-na 7.513 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None None XRAY 2.0 0.216 0.256 B 327 274 13 0 0 13 [[589, 926]] 1.0 8pqe Homo sapiens TYR_KIT_HUMAN TYR 2.4e-104 354.3 1 261 261 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR PTK2 FAK1_HUMAN 6YVYB Q05397 415 686 1052.0 P1E:701 Type1 None DFGin 6.76 16.154 BLAminus DFGAsp-rot-in -125.37, -159.56 46.15, 75.22 187.83, 86.46 -98.8, 22.63 289.45, 61.98 -103.7, -1.46 in-in in 8.082 Saltbr-in 2.884 HRD-in -68.13, -50.71 78.23, -5.43 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.05 APE8-dihe-in -81.82, 62.53 APE8-rot-na 30.96 APE67-dihe-in -65.78, -13.58 -48.49, -45.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.28 None None None XRAY 1.918 0.215 0.235 B 282 257 15 0 0 15 [[422, 678]] 1.0 6yvy Homo sapiens TYR_PTK2_HUMAN TYR 3.7e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SRC SRC_HUMAN 6E6EH P12931 261 536 536.0 HVY:601 Type1 None DFGin 7.029 15.265 BLAminus DFGAsp-rot-in -131.86, -170.63 59.19, 79.74 193.14, 11.06 -107.54, 18.21 299.51, 108.05 -63.79, -34.15 in-in in 8.533 Saltbr-in 2.729 HRD-in -94.19, -44.57 77.57, -18.69 in-in-none SNCiin in-none ActLoopNT-in 3.395 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.64 APE8-dihe-in -69.1, 125.41 APE8-rot-na 27.89 APE67-dihe-in -65.46, -25.99 -62.37, -38.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.112 None None None XRAY 2.15 0.252 0.285 H 276 264 12 0 0 12 [[270, 521]] 1.0 6e6e Homo sapiens TYR_SRC_HUMAN TYR 1.5e-94 322.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOA P12931 260 536 536.0 DB8:60601 Type1 None DFGin 6.485 14.992 BLAminus DFGAsp-rot-in -136.89, -177.13 60.13, 67.22 210.35, -70.32 -88.08, 17.88 299.37, 80.4 -39.41, -49.93 in-in in 8.209 Saltbr-in 3.007 HRD-in -88.6, -49.05 78.24, -0.79 in-in-none SNCiin in-none ActLoopNT-in 2.923 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.4 APE8-dihe-in -68.65, 109.43 APE8-rot-na 30.28 APE67-dihe-in -65.46, -35.11 -60.6, -22.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.961 None None None XRAY 2.105 0.212 0.254 A 286 266 11 0 0 11 [[270, 521]] 1.0 4mxo Homo sapiens TYR_SRC_HUMAN TYR 1.7e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 4MXOB P12931 261 536 536.0 DB8:60601 Type1 None DFGin 6.117 14.771 BLAminus DFGAsp-rot-in -143.71, -172.1 53.51, 74.85 217.28, -77.55 -94.55, 12.21 299.33, 86.01 -48.26, -39.95 in-in in 7.978 Saltbr-in 3.027 HRD-in -94.91, -49.82 82.99, -7.9 in-in-none SNCiin in-none ActLoopNT-in 2.965 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.53 APE8-dihe-in -48.6, 109.34 APE8-rot-na 16.54 APE67-dihe-in -71.78, -28.01 -62.09, -30.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.732 None None None XRAY 2.105 0.212 0.254 B 286 264 12 0 0 12 [[270, 521]] 1.0 4mxo Homo sapiens TYR_SRC_HUMAN TYR 1.7e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_HUMAN 6ATEA P12931 260 536 536.0 6H3:601 Type1 None DFGin 7.041 15.169 BLAminus DFGAsp-rot-in -135.65, -168.07 66.14, 79.15 191.72, 15.79 -116.32, 24.48 292.22, 93.52 -64.92, -24.87 in-in in 7.679 Saltbr-in 3.4 HRD-in -88.24, -48.16 78.13, -11.21 in-in-none SNCiin in-none ActLoopNT-in 2.938 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 49.92 APE8-rot-na 24.35 APE67-dihe-in -67.09, -18.78 -61.23, -36.71 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.402 0.195 0.228 A 286 255 22 0 0 14 [[270, 521]] 1.0 6ate Homo sapiens TYR_SRC_HUMAN TYR 1.7e-94 322.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SYK KSYK_HUMAN 1XBBA P43405 363 635 635.0 STI:60001 Type1 None DFGin 6.664 14.623 BLAminus DFGAsp-rot-in -128.05, 176.75 68.38, 79.08 204.6, -30.64 -100.61, 19.15 290.6, 90.35 -58.48, -28.27 in-in in 8.236 Saltbr-in 3.032 HRD-in -76.13, -51.62 74.69, 4.56 in-in-none SNCiin in-none ActLoopNT-in 2.878 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 178.76 APE9-dihe-in -111.48, 137.0 APE8-dihe-in -74.08, 70.57 APE8-rot-na 29.87 APE67-dihe-in -65.65, -14.73 -52.2, -36.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.126 APE9-dist-na 7.2 None None None XRAY 1.57 0.191 0.221 A 291 264 9 0 0 4 [[370, 628]] 1.0 1xbb Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3FQHB P43405 363 633 635.0 057:2 Type1 None DFGin 6.512 14.384 BLAminus DFGAsp-rot-in -135.61, -177.0 61.05, 83.05 203.68, -27.77 -100.81, 28.19 289.97, 93.91 -68.13, -27.21 in-in in 7.95 Saltbr-in 2.929 HRD-in -70.78, -57.98 73.35, 4.27 in-in-none SNCiin in-none ActLoopNT-in 2.946 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 140.44 APE9-dihe-in -122.67, 149.45 APE8-dihe-in -71.04, 64.02 APE8-rot-na 27.55 APE67-dihe-in -70.95, -10.14 -42.56, -38.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.931 APE9-dist-na 7.058 None None None XRAY 2.26 0.216 0.259 B 291 258 13 0 0 4 [[370, 628]] 1.0 3fqh Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3FQSA P43405 363 635 635.0 585:60001 Type1 None DFGin 6.671 15.119 BLAminus DFGAsp-rot-in -130.1, -168.06 51.07, 81.04 201.27, -8.08 -99.05, 21.72 287.94, 89.19 -65.06, -25.56 in-in in 8.251 Saltbr-in 2.89 HRD-in -73.57, -53.38 73.0, 6.23 in-in-none SNCiin in-none ActLoopNT-in 2.927 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 124.94 APE9-dihe-in -106.74, 133.78 APE8-dihe-in -71.17, 66.53 APE8-rot-na 27.84 APE67-dihe-in -63.27, -16.28 -46.11, -40.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.716 APE9-dist-na 7.49 None None None XRAY 2.1 0.218 0.253 A 291 264 9 0 0 4 [[370, 628]] 1.0 3fqs Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FYNA P43405 363 635 635.0 0VE:60701 Type1 None DFGin 6.322 14.552 BLAminus DFGAsp-rot-in -125.05, -173.65 56.58, 84.17 192.6, 0.66 -104.44, 22.0 295.83, 84.03 -64.28, -16.7 in-in in 8.168 Saltbr-in 2.747 HRD-in -77.65, -54.89 74.1, 7.86 in-in-none SNCiin in-none ActLoopNT-in 2.924 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 150.74 APE9-dihe-in -119.38, 130.75 APE8-dihe-in -71.21, 75.44 APE8-rot-na 25.91 APE67-dihe-in -62.88, -14.32 -62.84, -38.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.751 APE9-dist-na 7.34 None None None XRAY 2.318 0.228 0.269 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyn Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FZ6A P43405 363 635 635.0 0VG:60701 Type1 None DFGin 6.317 14.691 BLAminus DFGAsp-rot-in -133.65, -169.74 58.51, 78.15 191.33, -6.29 -100.44, 26.78 291.45, 90.91 -64.04, -31.24 in-in in 8.443 Saltbr-in 3.006 HRD-in -75.46, -52.97 71.45, 4.73 in-in-none SNCiin in-none ActLoopNT-in 2.901 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 139.2 APE9-dihe-in -115.79, 143.14 APE8-dihe-in -76.09, 69.74 APE8-rot-na 28.85 APE67-dihe-in -66.47, -14.43 -53.02, -38.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.466 APE9-dist-na 7.234 None None None XRAY 1.85 0.23 0.253 A 291 262 11 0 0 4 [[370, 628]] 1.0 4fz6 Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4I0RA P43405 363 635 635.0 1B4:60701 Type1 None DFGin 6.303 14.472 BLAminus DFGAsp-rot-in -120.7, -175.74 66.13, 76.03 192.36, -6.54 -99.52, 27.66 293.49, 90.9 -68.19, -27.87 in-in in 8.079 Saltbr-in 2.795 HRD-in -77.52, -55.13 72.71, 3.63 in-in-none SNCiin in-none ActLoopNT-in 2.856 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 132.26 APE9-dihe-in -103.47, 139.74 APE8-dihe-in -70.94, 75.19 APE8-rot-na 28.76 APE67-dihe-in -61.34, -17.47 -59.11, -38.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.727 APE9-dist-na 7.158 None None None XRAY 2.1 0.237 0.272 A 291 260 13 0 0 4 [[370, 628]] 1.0 4i0r Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4I0SA P43405 363 635 635.0 1B5:60701 Type1 None DFGin 6.348 14.318 BLAminus DFGAsp-rot-in -129.27, -175.27 55.43, 83.6 204.86, -24.79 -98.08, 24.19 289.58, 86.12 -61.12, -27.32 in-in in 8.034 Saltbr-in 2.589 HRD-in -71.15, -52.29 70.43, 7.1 in-in-none SNCiin in-none ActLoopNT-in 2.926 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 126.23 APE9-dihe-in -113.12, 145.51 APE8-dihe-in -74.21, 66.56 APE8-rot-na 27.25 APE67-dihe-in -64.4, -15.49 -48.66, -38.26 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.673 APE9-dist-na 7.239 None None None XRAY 1.98 0.218 0.236 A 291 263 10 0 0 4 [[370, 628]] 1.0 4i0s Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4I0TA P43405 363 635 635.0 1B6:60701 Type1 None DFGin 6.448 14.275 BLAminus DFGAsp-rot-in -133.28, -166.54 54.17, 83.04 203.23, -16.65 -99.17, 23.72 289.92, 92.88 -54.78, -30.8 in-in in 8.482 Saltbr-in 2.757 HRD-in -78.62, -52.01 75.91, 3.75 in-in-none SNCiin in-none ActLoopNT-in 3.005 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.47 APE8-dihe-in -63.58, 54.66 APE8-rot-na 27.19 APE67-dihe-in -65.32, -17.31 -39.09, -36.25 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.562 None None None XRAY 1.7 0.236 0.268 A 291 262 11 0 0 5 [[370, 628]] 1.0 4i0t Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5T68A P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.399 14.233 BLAminus DFGAsp-rot-in -118.2, -175.03 55.02, 90.22 214.09, -22.65 -105.11, 31.93 294.35, 102.52 -80.93, -22.27 in-in in 7.864 Saltbr-in 2.767 HRD-in -79.38, -47.76 69.54, -3.58 in-in-none SNCiin in-none ActLoopNT-in 3.07 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -53.8 APE9-dihe-in -121.95, 75.31 APE8-dihe-in -77.88, 51.45 APE8-rot-na 19.76 APE67-dihe-in -78.2, -26.54 -39.48, -21.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.291 APE9-dist-na 7.587 None None None XRAY 2.93 0.188 0.281 A 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5T68B P43405 363 635 635.0 77V:60701 Type1 None DFGin 6.335 14.549 BLAminus DFGAsp-rot-in -125.81, -173.18 53.62, 72.36 200.55, -14.17 -90.46, 31.38 289.78, 97.36 -69.64, -47.12 in-in in 7.859 Saltbr-in 2.795 HRD-in -56.8, -40.48 64.3, -8.06 in-in-none SNCiin in-none ActLoopNT-in 2.996 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -66.53 APE9-dihe-in -122.76, 73.0 APE8-dihe-in -76.02, 70.05 APE8-rot-na 29.83 APE67-dihe-in -58.48, -8.81 -36.73, -49.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.244 APE9-dist-na 6.86 None None None XRAY 2.93 0.188 0.281 B 291 264 9 0 0 4 [[370, 628]] 1.0 5t68 Homo sapiens TYR_SYK_HUMAN TYR 5.7e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5Y5UB P43405 363 629 635.0 8OU:701 Type1 None DFGin 6.322 13.999 BLAminus DFGAsp-rot-in -136.83, 172.48 60.12, 69.06 200.21, -19.72 -76.3, 17.06 301.14, 79.7 -45.71, -46.86 in-in in 7.647 Saltbr-in 2.798 HRD-in -72.89, -51.34 74.65, -2.0 in-in-none SNCiin in-none ActLoopNT-in 2.821 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 45.91 APE8-rot-na 27.44 APE67-dihe-in -59.42, -23.8 -55.69, -38.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.14 0.239 0.26 B 293 257 10 0 0 6 [[370, 628]] 1.0 5y5u Homo sapiens TYR_SYK_HUMAN TYR 5.8e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3VF8A P43405 363 635 635.0 0JE:701 Type1 None DFGin 6.303 14.274 BLAminus DFGAsp-rot-in -127.47, -170.59 55.16, 83.49 191.7, 10.26 -101.53, 21.98 288.96, 89.41 -58.75, -35.76 in-none in 8.043 Saltbr-none 999.0 HRD-in -73.27, -51.41 67.21, 6.99 none-in-in SNCnii in-in ActLoopNT-in 2.985 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -67.14, 90.57 APE9-dihe-in -105.62, 138.03 APE8-dihe-in -81.27, 73.81 APE8-rot-na 26.23 APE67-dihe-in -66.47, -16.98 -51.38, -34.52 APE12-dist-na 13.257 APE11-dist-na 10.092 APE10-dist-na 10.007 APE9-dist-na 6.796 None None None XRAY 2.08 0.217 0.241 A 299 265 8 0 0 0 [[370, 628]] 1.0 3vf8 Homo sapiens TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 3VF9A P43405 364 635 635.0 477:701 Type1 None DFGin 6.396 14.64 BLAminus DFGAsp-rot-in -128.07, -174.94 57.37, 81.54 194.35, 12.97 -100.98, 31.05 291.59, 91.29 -68.94, -37.68 in-none in 7.996 Saltbr-none 999.0 HRD-in -72.91, -49.87 65.85, 9.08 none-in-in SNCnii in-in ActLoopNT-in 3.023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -64.57, 94.78 APE9-dihe-in -116.96, 141.01 APE8-dihe-in -83.94, 81.53 APE8-rot-na 20.28 APE67-dihe-in -58.58, -19.75 -44.92, -48.84 APE12-dist-na 13.207 APE11-dist-na 10.508 APE10-dist-na 9.877 APE9-dist-na 6.696 None None None XRAY 2.3 0.255 0.267 A 299 265 7 0 0 0 [[370, 628]] 1.0 3vf9 Homo sapiens TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6ZCRA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus DFGAsp-rot-in -131.25, -174.99 58.52, 82.29 194.43, -8.77 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcr Homo sapiens TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 6ZCUA P43405 363 635 635.0 5JG:60701 Type1 None DFGin 6.691 14.616 BLAminus DFGAsp-rot-in -131.25, -174.99 58.52, 82.29 194.43, -8.77 -98.4, 23.45 287.56, 81.54 -60.43, -25.78 in-in in 8.005 Saltbr-in 2.921 HRD-in -78.76, -53.73 70.25, 7.39 in-in-none SNCiin in-none ActLoopNT-in 2.804 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.61 APE8-dihe-in -81.67, 70.3 APE8-rot-na 33.8 APE67-dihe-in -65.02, -14.57 -49.04, -40.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.715 None None None XRAY 1.73 0.189 0.218 A 299 264 9 0 0 4 [[370, 628]] 1.0 6zcu Homo sapiens TYR_SYK_HUMAN TYR 6.3e-90 307.0 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR TNK2 ACK1_HUMAN 1U4DA Q07912 117 389 1038.0 DBQ:398 Type1 None DFGin 6.5 13.536 BLAminus DFGAsp-rot-in -127.17, -169.67 54.12, 72.77 205.32, -17.94 -87.16, 24.56 310.51, 109.17 -62.52, -20.25 in-in in 8.735 Saltbr-in 3.176 HRD-in -80.08, -48.95 65.72, 7.9 in-in-none SNCiin in-none ActLoopNT-in 3.172 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -41.24 APE8-dihe-in -76.48, 82.61 APE8-rot-na 31.13 APE67-dihe-in -69.93, -17.0 -48.99, -48.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.562 None None None XRAY 2.1 0.205 0.248 A 291 258 15 0 0 7 [[126, 387]] 1.0 1u4d Homo sapiens TYR_TNK2_HUMAN TYR 9.3e-86 293.3 1 259 259 269 270 271 273 275 158 177 181 249 251 250 252 312 300 295 294 293 292 291 290 289 206 Activated CDC42 kinase 1
TYR TYK2-2 TYK2_HUMAN 7UYSA P29597 890 1177 1187.0 OVC:1201 Type1 None DFGin 6.822 13.649 BLAminus DFGAsp-rot-in -114.45, -171.35 44.56, 84.78 206.53, -7.12 -101.1, 35.58 297.8, 80.57 -68.2, -34.51 in-in in 8.175 Saltbr-in 2.706 HRD-in -81.8, -57.11 76.46, 1.75 in-in-none SNCiin in-none ActLoopNT-in 2.909 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -43.18 APE9-dihe-in -68.5, 119.8 APE8-dihe-in -75.42, 76.63 APE8-rot-na 32.55 APE67-dihe-in -73.48, -8.09 -58.48, -34.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.841 APE9-dist-na 6.505 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.15 0.232 0.272 A 289 282 6 0 0 4 [[589, 868], [897, 1171]] 2.0 7uys Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 7UYUA P29597 889 1177 1187.0 OV0:1201 Type1 None DFGin 6.732 13.693 BLAminus DFGAsp-rot-in -116.0, -173.86 46.69, 88.81 204.6, -11.04 -102.3, 31.38 294.59, 76.31 -71.39, -32.91 in-in in 7.837 Saltbr-in 3.038 HRD-in -86.52, -53.34 77.94, 2.86 in-in-none SNCiin in-none ActLoopNT-in 2.911 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.29 APE8-dihe-in -82.32, 79.72 APE8-rot-na 31.91 APE67-dihe-in -72.66, -7.56 -62.66, -28.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.58 None PTR1054,PTR1055 PTR1054,PTR1055 XRAY 2.05 0.227 0.257 A 289 269 20 0 0 7 [[589, 868], [897, 1171]] 2.0 7uyu Homo sapiens TYR_TYK2-2_HUMAN TYR 1.1e-81 279.9 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-2 TYK2_HUMAN 6AAMA P29597 888 1178 1187.0 9T6:1201 Type1 None DFGin 6.808 13.614 BLAminus DFGAsp-rot-in -114.96, -166.83 46.97, 77.56 198.31, -12.49 -91.7, 20.81 290.41, 78.57 -55.84, -27.39 in-in in 7.95 Saltbr-in 2.732 HRD-in -93.28, -50.85 70.68, 8.06 in-in-none SNCiin in-none ActLoopNT-in 2.803 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 25.87 APE8-rot-na 15.0 APE67-dihe-in -73.41, -4.27 -60.18, -33.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 C936A,Q969A,E971A,K972A,D1023N,I1114L,C1142A None None XRAY 1.98 0.204 0.238 A 298 269 22 0 0 14 [[589, 868], [897, 1171]] 2.0 6aam Homo sapiens TYR_TYK2-2_HUMAN TYR 3.5e-81 278.3 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
AGC PRKCI KPCI_MOUSE 4DC2A Q62074 248 586 595.0 ADE:60601 Type1 None DFGin 5.514 11.595 BLAminus DFGAsp-rot-in -116.21, -173.67 60.87, 97.17 203.3, -17.4 -103.56, 4.24 303.35, 138.78 -42.92, -43.52 in-none in 9.099 Saltbr-none 999.0 HRD-in -77.29, -48.77 70.59, -5.86 none-in-in SNCnii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.58, 165.79 APE9-dihe-na 134.32, -165.14 APE8-dihe-in -104.82, 125.13 APE8-rot-in 306.69 APE67-dihe-in -51.64, -27.58 -50.63, -43.23 APE12-dist-in 8.611 APE11-dist-in 11.606 APE10-dist-in 6.22 APE9-dist-in 3.688 None TPO563 TPO563 XRAY 2.4 0.176 0.241 A 396 329 10 0 0 0 [[253, 521]] 1.0 4dc2 Mus musculus AGC_PRKCI_MOUSE AGC 1.2e-94 322.3 1 260 260 394 395 396 398 400 282 301 305 374 376 375 377 434 422 417 416 415 414 413 412 411 332 Protein kinase C iota type
CAMK MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.712 14.57 BLAminus DFGAsp-rot-in -130.6, -176.06 61.21, 74.64 210.74, 7.94 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.847 Saltbr-in 2.958 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.443 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334 308 17 0 0 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.4e-88 301.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_MOUSE 4CQGA Q61846 2 326 643.0 OT5:61332 Type1 None DFGin 6.312 14.194 BLAminus DFGAsp-rot-in -132.87, 178.1 63.59, 73.65 223.43, -34.48 -97.71, 18.69 288.44, 92.66 -66.54, -24.22 in-in in 9.21 Saltbr-in 3.071 HRD-in -69.96, -53.3 76.88, 4.58 in-in-none SNCiin in-none ActLoopNT-in 2.962 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 156.81 APE9-dihe-na 87.85, 175.2 APE8-dihe-in -57.99, 138.67 APE8-rot-in 288.02 APE67-dihe-in -62.14, -25.5 -62.1, -43.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.7 APE9-dist-in 3.91 T167E None None XRAY 2.57 0.207 0.251 A 331 308 17 0 0 12 [[11, 263]] 1.0 4cqg Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CMGC MAPK14 MK14_MOUSE 5NZZH P47811 5 352 360.0 AGS:60500 ATPlike None DFGin 6.52 14.912 BLAminus DFGAsp-rot-in -107.76, 173.34 60.28, 95.29 194.35, -27.89 -107.52, 29.84 280.25, 79.55 -61.87, -24.37 in-none in 9.249 Saltbr-none 999.0 HRD-in -88.17, -55.8 88.26, -17.82 none-in-in SNCnii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.4, 153.2 APE9-dihe-na 72.78, 157.17 APE8-dihe-in -63.99, 158.8 APE8-rot-in 301.47 APE67-dihe-in -70.1, -20.58 -71.77, -51.25 APE12-dist-in 12.048 APE11-dist-in 11.371 APE10-dist-in 7.651 APE9-dist-in 3.35 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 H 360 337 9 0 0 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TKL RIPK3 RIPK3_MOUSE 4M66B Q9QZL0 14 313 486.0 No_ligand No_ligand None DFGin 6.257 13.906 BLAminus DFGAsp-rot-in -131.04, 173.42 61.1, 97.0 189.32, 12.92 -115.48, 32.44 299.35, 93.88 -64.23, -38.27 in-in in 8.429 Saltbr-in 2.396 HRD-in -76.55, -48.31 73.84, -8.87 in-in-none SNCiin in-none ActLoopNT-in 2.49 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.87, -4.86 999.0, -21.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C111A None None XRAY 2.401 0.217 0.258 B 325 265 35 0 0 19 [[20, 290]] 1.0 4m66 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX2B Q9QZL0 13 313 486.0 No_ligand No_ligand None DFGin 6.33 13.859 BLAminus DFGAsp-rot-in -148.46, -178.51 60.6, 72.26 194.1, 4.98 -92.16, 23.07 300.89, 97.28 -69.06, -26.68 in-in in 8.252 Saltbr-in 2.687 HRD-in -69.09, -48.01 69.12, -1.67 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.27 APE8-rot-in 299.69 APE67-dihe-in -70.84, -21.22 -92.23, 4.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.23 0.276 B 325 264 37 0 0 19 [[20, 290]] 1.0 9ix2 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX0A Q9QZL0 15 312 486.0 A1D99:401 Type1 None DFGin 6.175 14.031 BLAminus DFGAsp-rot-in -143.29, 171.72 60.25, 76.29 197.6, -6.62 -91.31, 27.47 299.18, 101.06 -70.53, -25.92 in-in in 8.508 Saltbr-in 2.757 HRD-in -63.18, -53.03 70.09, 0.01 in-in-none SNCiin in-none ActLoopNT-in 2.729 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.23 APE8-dihe-in -50.23, 128.69 APE8-rot-in 297.82 APE67-dihe-in -60.6, -26.4 -69.61, -32.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.583 None None None XRAY 2.1 0.205 0.243 A 325 269 29 0 0 17 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX0B Q9QZL0 13 311 486.0 A1D99:401 Type1 None DFGin 6.254 13.905 BLAminus DFGAsp-rot-in -148.35, -179.19 58.25, 77.83 194.68, -1.84 -96.97, 28.2 308.45, 66.53 -68.51, -30.59 in-in in 8.662 Saltbr-in 3.043 HRD-in -69.9, -51.03 76.13, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.728 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -72.8 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.86 -71.87, -10.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.205 0.243 B 325 255 44 0 0 19 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX1A Q9QZL0 15 313 486.0 PP2:60401 Type1 None DFGin 5.913 14.386 BLAminus DFGAsp-rot-in -149.4, 179.25 53.78, 84.76 202.16, -25.4 -98.68, 28.86 296.35, 93.86 -68.88, -29.86 in-in in 8.49 Saltbr-in 2.82 HRD-in -73.45, -52.59 70.92, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.862 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -23.19 999.0, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 A 325 268 31 0 0 19 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVGA Q9QZL0 14 312 486.0 LKR:401 Type1 None DFGin 5.994 13.863 BLAminus DFGAsp-rot-in -143.57, 178.7 54.72, 82.38 196.27, -9.99 -98.67, 31.08 302.44, 93.08 -71.32, -23.61 in-in in 8.503 Saltbr-in 2.534 HRD-in -71.75, -46.38 68.0, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.84 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.4 APE8-rot-none 999.0 APE67-dihe-in -65.94, -24.52 -63.59, -34.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 A 325 268 31 0 0 18 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVGB Q9QZL0 14 311 486.0 LKR:401 Type1 None DFGin 6.084 13.882 BLAminus DFGAsp-rot-in -141.96, 177.06 54.0, 89.88 198.27, -8.41 -106.67, 29.11 304.14, 81.96 -69.4, -38.51 in-in in 8.544 Saltbr-in 2.772 HRD-in -66.91, -46.81 64.26, 6.52 in-in-none SNCiin in-none ActLoopNT-in 2.685 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.66, -18.61 999.0, 5.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 B 325 250 48 0 0 19 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.25 14.259 BLAminus DFGAsp-rot-in -136.98, 168.96 62.75, 89.32 198.72, 4.07 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.376 Saltbr-in 2.879 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325 263 37 0 0 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.144 14.058 BLAminus DFGAsp-rot-in -139.36, 174.01 57.76, 83.37 192.45, 4.04 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.581 Saltbr-in 2.817 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325 266 34 0 0 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IWWA Q9QZL0 13 312 486.0 A1D96:401 Type1.5_Back None DFGin 5.986 13.437 BLAminus DFGAsp-rot-in -144.16, 173.05 63.98, 84.62 200.57, -26.53 -101.11, 24.14 300.74, 93.26 -71.71, -26.9 in-in in 8.088 Saltbr-in 2.888 HRD-in -71.21, -48.68 73.29, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.715 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -153.01 APE9-dihe-na 106.36, 163.97 APE8-dihe-in -82.15, 128.32 APE8-rot-in 297.93 APE67-dihe-in -63.89, -25.3 -71.15, -26.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.411 APE9-dist-in 5.408 None None None XRAY 1.93 0.183 0.209 A 325 284 16 0 0 16 [[20, 290]] 1.0 9iww Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IWZA Q9QZL0 13 312 486.0 ZOV:401 Type1.5_Back None DFGin 6.167 13.332 BLAminus DFGAsp-rot-in -140.79, 171.83 65.16, 90.29 193.53, -12.4 -104.26, 18.26 298.04, 95.08 -65.53, -28.75 in-in in 7.87 Saltbr-in 2.858 HRD-in -70.03, -51.19 78.93, -3.69 in-in-none SNCiin in-none ActLoopNT-in 2.767 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -29.88 APE9-dihe-na 105.08, -174.88 APE8-dihe-in -93.5, 124.97 APE8-rot-in 297.04 APE67-dihe-in -65.66, -19.22 -68.64, -29.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.387 APE9-dist-in 5.623 None None None XRAY 1.82 0.178 0.211 A 325 285 15 0 0 15 [[20, 290]] 1.0 9iwz Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IWXA Q9QZL0 14 311 486.0 A1D96:401 Type1.5_Back None DFGin 6.485 13.836 BLAminus DFGAsp-rot-in -139.34, 174.94 62.89, 84.12 206.04, -33.2 -98.91, 17.96 292.01, 88.18 -69.55, -33.91 in-in in 8.085 Saltbr-in 2.79 HRD-in -70.26, -48.65 73.87, -6.66 in-in-none SNCiin in-none ActLoopNT-in 2.711 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.28 APE8-rot-in 301.73 APE67-dihe-in -62.28, -24.57 -68.16, -31.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R69H None None XRAY 1.99 0.189 0.236 A 325 280 18 0 0 18 [[20, 290]] 1.0 9iwx Mus musculus TKL_RIPK3_MOUSE TKL 8e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHB2 EPHB2_MOUSE 2HENA P54763 614 893 986.0 ADP:60400 ATPlike None DFGin 5.333 15.674 BLAminus DFGAsp-rot-in -133.74, -165.91 59.29, 70.83 179.59, 55.25 -103.82, 9.51 292.63, 82.7 -87.21, 999.0 in-in in 8.023 Saltbr-in 2.786 HRD-in -62.88, -49.36 74.49, -21.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.77 APE8-rot-na 327.53 APE67-dihe-in -57.52, -8.41 -44.64, -64.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 A 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENB P54763 614 893 986.0 ADP:60401 ATPlike None DFGin 4.876 14.888 BLAminus DFGAsp-rot-in -140.27, -169.83 69.21, 92.69 197.67, -65.34 -125.5, 35.8 302.49, 84.21 -59.5, 999.0 in-in in 8.267 Saltbr-in 2.839 HRD-in -71.96, -52.85 76.51, -19.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.95 APE8-rot-na 35.68 APE67-dihe-in -63.04, 8.29 -53.0, -58.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 B 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENC P54763 614 893 986.0 ADP:60402 ATPlike None DFGin 5.167 15.787 BLAminus DFGAsp-rot-in -136.6, -161.63 61.14, 70.93 183.58, 55.66 -108.31, 8.65 286.35, 98.46 -79.82, 999.0 in-in in 8.074 Saltbr-in 2.876 HRD-in -60.04, -43.18 71.33, -24.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.37 APE8-rot-na 329.62 APE67-dihe-in -67.84, -7.2 -58.96, -40.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 C 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HEND P54763 614 893 986.0 ADP:60403 ATPlike None DFGin 4.79 14.772 BLAminus DFGAsp-rot-in -150.33, -176.71 75.96, 94.04 193.06, -64.19 -126.18, 89.85 307.58, 79.07 -67.67, 999.0 in-in in 8.322 Saltbr-in 3.409 HRD-in -71.43, -49.79 75.74, -24.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.49 APE8-rot-na 333.13 APE67-dihe-in -68.61, 6.13 -48.05, -54.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 D 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
OTHER PKNB PKNB_MYCTU 1O6YA P9WI81 3 278 626.0 ACP:1279 ATPlike None DFGin 5.309 14.78 BLAminus DFGAsp-rot-in -139.04, -177.54 67.82, 83.57 189.66, -2.53 -97.92, 24.81 285.65, 79.79 -51.43, -35.15 in-in in 8.242 Saltbr-in 2.792 HRD-in -70.46, -52.6 71.79, -5.94 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.25, -16.6 999.0, -48.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.193 0.23 A 299 260 16 0 0 16 [[11, 273]] 1.0 1o6y Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.6e-46 162.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
CMGC MAPK1 MK01_RAT 3C9WA P63086 6 354 358.0 HMY:1 Type1 None DFGin 6.999 15.702 BLAminus DFGAsp-rot-in -123.81, 173.38 50.82, 89.77 192.89, 14.29 -103.35, 17.03 287.88, 69.21 -57.05, -26.18 in-in in 9.643 Saltbr-in 2.694 HRD-in -68.6, -50.76 75.06, -2.41 in-in-none SNCiin in-none ActLoopNT-in 2.74 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.03 APE8-rot-in 303.8 APE67-dihe-in -65.62, -21.36 -55.58, -26.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.197 0.274 A 357 336 13 0 0 13 [[23, 311]] 1.0 3c9w Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.2 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
TYR CSK CSK_RAT 1K9AA P32577 6 450 450.0 No_ligand No_ligand None DFGin 7.025 13.118 BLAminus DFGAsp-rot-in -139.67, -167.82 53.56, 74.8 198.77, -39.15 -92.76, 23.85 306.26, 90.9 -52.74, -52.0 in-in in 8.261 Saltbr-in 2.543 HRD-in -75.98, -39.34 59.35, 3.94 in-in-none SNCiin in-none ActLoopNT-in 2.904 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 146.13 APE9-dihe-in -90.54, 133.78 APE8-dihe-in -64.01, 107.63 APE8-rot-na 30.9 APE67-dihe-in -66.63, -13.65 -46.3, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.896 APE9-dist-na 4.946 None None None XRAY 2.5 0.246 0.288 A 450 439 6 0 0 6 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 8.1e-87 297.0 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CK1 HRR25 HRR25_YEAST 5CYZA P29295 1 388 494.0 No_ligand No_ligand None DFGin 6.229 15.334 BLAminus DFGAsp-rot-in -128.54, 179.51 66.19, 80.02 198.72, -10.94 -99.63, 19.66 287.65, 84.23 -59.34, -31.87 in-none in 8.328 Saltbr-none 999.0 HRD-in -79.26, -49.66 70.34, 12.02 none-in-in SNCnii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.13, -20.75 APE9-dihe-na -89.87, -152.56 APE8-dihe-in -86.32, 132.66 APE8-rot-in 308.22 APE67-dihe-in -57.09, -35.6 -67.98, -36.78 APE12-dist-in 11.78 APE11-dist-in 11.968 APE10-dist-in 6.445 APE9-dist-in 4.264 K38R None MLY8,MLY14,MLY130,MLY154,MLY155,MLY171,MLY222,MLY231,MLY256,MLY263,MLY274,MLY279,MLY335,MLY337,MLY352,MLY365 XRAY 1.841 0.165 0.192 A 395 368 0 0 0 0 [[9, 275]] 1.0 5cyz Saccharomyces cerevisiae CK1_HRR25_YEAST CK1 9.8e-102 346.0 1 261 261 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I homolog HRR25
CMGC FUS3 FUS3_YEAST 2F9GA P16892 1 353 353.0 ADP:500 ATPlike None DFGin 6.607 14.033 BLAminus DFGAsp-rot-in -131.87, -173.96 62.19, 67.37 224.02, -8.11 -94.01, 7.54 292.42, 102.61 -61.43, -28.32 in-in in 8.738 Saltbr-in 2.766 HRD-in -77.05, -50.83 75.67, -3.23 in-in-none SNCiin in-none ActLoopNT-in 2.955 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.43 APE8-rot-in 296.4 APE67-dihe-in -62.22, -26.66 -58.62, -16.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR182 PTR182 XRAY 2.1 0.211 0.26 A 353 332 21 0 0 21 [[13, 309]] 1.0 2f9g Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.3e-75 258.5 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
OTHER BUD32 BUD32_YEAST 4WWAA P53323 4 253 261.0 No_ligand No_ligand None DFGin 6.819 15.236 BLAminus DFGAsp-rot-in -144.51, 174.66 32.61, 87.29 185.86, 52.44 -96.28, 31.48 285.55, 91.16 -60.3, -51.25 in-none in 7.46 Saltbr-none 999.0 HRD-in -77.93, -56.43 73.9, 41.54 none-in-na SNCnia in-na ActLoopNT-in 2.562 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -65.7, -37.17 APE9-dihe-na -68.09, -40.47 APE8-dihe-na -61.67, -53.02 APE8-rot-na 213.04 APE67-dihe-na -52.82, -48.51 -50.09, -51.8 APE12-dist-na 16.267 APE11-dist-na 11.778 APE10-dist-na 15.171 APE9-dist-na 12.257 None None None XRAY 2.953 0.221 0.296 A 261 224 34 0 0 0 [[17, 261]] 1.0 4wwa Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5.2e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER IRE1 IRE1_YEAST 2RIOA P32361 665 1115 1115.0 ADP:61101 ATPlike None DFGin 5.032 14.666 BLAminus DFGAsp-rot-in -125.01, -166.82 59.91, 72.41 199.47, -11.39 -79.74, 13.1 278.94, 57.84 -50.86, -29.29 out-in out 10.36 Saltbr-in 3.544 HRD-in -69.38, -55.95 80.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.684 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.77 APE8-rot-in 240.38 APE67-dihe-in -59.81, -10.2 -102.36, 14.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 A 434 396 26 0 0 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0A P32361 665 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.657 14.52 BLAminus DFGAsp-rot-in -127.75, -159.8 55.73, 76.2 196.46, -18.32 -100.97, 26.65 278.19, 55.54 -68.42, -38.12 in-in in 9.315 Saltbr-in 3.043 HRD-in -75.54, -40.03 69.65, -11.03 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.99 APE8-rot-none 999.0 APE67-dihe-in -81.59, -8.09 -104.48, 18.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 A 434 407 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0B P32361 670 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.639 14.529 BLAminus DFGAsp-rot-in -127.76, -160.17 56.44, 75.29 195.96, -17.67 -99.49, 26.48 278.86, 54.86 -67.91, -37.63 in-in in 9.332 Saltbr-in 3.088 HRD-in -76.48, -40.82 70.18, -10.34 in-in-none SNCiin in-none ActLoopNT-in 2.864 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.45 APE8-rot-in 292.53 APE67-dihe-in -81.7, -8.3 -104.03, 18.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 B 434 402 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ1A P32361 665 1115 1115.0 DKI:1 Type1 None DFGin 5.549 14.198 BLAminus DFGAsp-rot-in -134.05, -172.29 64.43, 86.72 195.45, -16.5 -105.73, 31.33 281.55, 58.87 -71.4, -43.5 in-in in 9.069 Saltbr-in 2.771 HRD-in -75.98, -46.34 75.54, -5.83 in-in-none SNCiin in-none ActLoopNT-in 2.858 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.95 APE8-rot-none 999.0 APE67-dihe-in -76.17, -21.3 -105.55, 30.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.264 0.284 A 434 407 20 0 0 7 [[672, 977]] 1.0 3lj1 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ1B P32361 665 1115 1115.0 DKI:1 Type1 None DFGin 5.566 14.194 BLAminus DFGAsp-rot-in -134.95, -174.09 65.23, 87.06 196.07, -14.43 -105.31, 31.78 281.4, 59.08 -71.99, -43.07 in-in in 9.066 Saltbr-in 2.849 HRD-in -76.02, -48.57 76.62, -4.7 in-in-none SNCiin in-none ActLoopNT-in 2.883 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.69 APE8-rot-none 999.0 APE67-dihe-in -76.4, -21.31 -105.99, 30.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.264 0.284 B 434 407 20 0 0 7 [[672, 977]] 1.0 3lj1 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ROP18 ROP18_TOXGO 4JRNA Q2PAY2 187 548 554.0 ANP:601 Allosteric None DFGin 8.982 15.869 BLAminus DFGAsp-rot-in -128.68, -167.44 58.76, 57.13 201.11, 49.38 -87.53, 25.8 281.08, 82.06 -67.92, -21.93 in-in in 8.183 Saltbr-in 2.992 HRD-in -70.13, -31.0 63.02, -2.32 in-in-none SNCiin in-none ActLoopNT-in 2.384 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.51 APE8-dihe-in -78.23, 127.04 APE8-rot-in 289.7 APE67-dihe-inflip 110.21, -8.27 -63.71, 127.69 APE12-dist-in 10.007 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None None None XRAY 2.71 0.235 0.289 A 372 349 6 0 0 2 [[253, 531]] 1.0 4jrn Toxoplasma gondii OTHER_ROP18_TOXGO CAMK 0.041 76.6 5 55 197 426 427 428 430 432 281 300 304 406 408 407 409 465 450 445 444 443 442 441 440 439 0 Serine/threonine-protein kinase ROP18

Activity: None (unassigned)

Total number of chains: 50
Active chains: 0
Total number of genes: 17
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 50 100.0% 5NTJA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL FERONIA FERON_ARATH 9UBIB Q9SCZ4 521 816 895.0 OT5:901 Type1 None DFGin 6.782 15.892 BLAminus DFGAsp-rot-in -126.95, 177.64 72.17, 75.0 196.1, 6.81 -97.07, 12.88 279.92, 75.65 -57.81, -31.55 in-in in 8.98 Saltbr-in 2.654 HRD-in -66.15, -44.35 78.97, -8.69 in-in-none SNCiin in-none ActLoopNT-in 2.796 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.59 APE8-dihe-in -127.69, 126.66 APE8-rot-in 307.15 APE67-dihe-inflip 94.57, -22.8 -51.35, 136.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.69 None None None XRAY 1.9 0.172 0.203 B 327 282 14 0 0 14 [[535, 809]] 1.0 9ubi Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2.4e-57 200.5 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA A0A6H0TJ16 1 862 872.0 ATP:60902 ATPlike None DFGin 6.64 14.881 BLAminus DFGAsp-rot-in -119.81, 176.45 65.16, 86.81 194.33, 0.5 -107.13, 32.95 280.75, 71.48 -74.73, -19.84 in-in in 7.41 Saltbr-in 2.775 HRD-na-- -76.54, -26.64 101.12, -25.28 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 A 904 845 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.5e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAOD A0A6H0TJ16 4 862 872.0 No_ligand No_ligand None DFGin 6.279 14.693 BLAminus DFGAsp-rot-in -127.01, -175.75 60.9, 110.51 197.96, -17.24 -134.43, 28.25 273.89, 91.9 -76.89, -10.35 in-in in 7.91 Saltbr-in 2.986 HRD-na-- -74.11, -15.09 88.71, -29.49 in-in-none SNCiin in-none ActLoopNT-in 2.822 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.502 0.249 0.307 D 859 845 0 0 0 0 [[228, 410]] 1.0 8sao Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.4 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
AGC PRKACA KAPCA_BOVIN 9DW8G P00517 15 329 351.0 ANP:403 ATPlike None DFGin 6.07 14.235 BLAminus DFGAsp-rot-in -131.43, -174.72 59.27, 66.66 212.77, -31.96 -86.28, 33.46 293.19, 93.28 -61.23, -49.05 in-none in 9.911 Saltbr-none 999.0 HRD-in -98.32, -49.71 57.42, 11.15 none-in-in SNCnii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.06, 160.73 APE9-dihe-na 123.3, -175.7 APE8-dihe-in -89.52, 132.72 APE8-rot-in 298.44 APE67-dihe-in -69.93, -27.98 -56.75, -38.6 APE12-dist-in 8.7 APE11-dist-in 11.593 APE10-dist-in 6.411 APE9-dist-in 4.803 None TPO198 TPO198 EM 3.5 999.0 999.0 G 351 309 0 0 0 0 [[44, 298]] 1.0 9dw8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EH2A P25321 1 351 351.0 AMP:60401 ATPlike None DFGin 6.764 14.919 BLAminus DFGAsp-rot-in -126.18, 164.33 76.56, 92.11 196.17, -17.64 -105.87, 26.81 282.23, 79.7 -66.18, -22.24 in-none in 9.226 Saltbr-none 999.0 HRD-in -87.75, -53.65 70.54, 10.24 none-in-in SNCnii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.34, 158.08 APE9-dihe-na 131.59, -168.87 APE8-dihe-in -114.41, 135.93 APE8-rot-in 298.36 APE67-dihe-in -58.8, -22.41 -48.5, -50.6 APE12-dist-in 8.204 APE11-dist-in 11.426 APE10-dist-in 5.845 APE9-dist-in 3.719 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.76 0.177 0.21 A 353 343 3 0 0 0 [[44, 298]] 1.0 6eh2 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 5NTJA P25321 1 351 351.0 No_ligand No_ligand None DFGin 6.758 15.589 BLAminus DFGAsp-rot-in -126.6, 164.17 70.8, 88.44 204.78, -18.34 -97.34, 22.68 279.05, 78.65 -62.01, -27.43 in-none in 9.318 Saltbr-none 999.0 HRD-in -87.71, -52.99 72.74, 12.02 none-in-in SNCnii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.35, 157.73 APE9-dihe-na 127.06, -161.94 APE8-dihe-in -121.61, 135.07 APE8-rot-in 297.67 APE67-dihe-in -60.56, -23.81 -48.81, -50.06 APE12-dist-in 8.184 APE11-dist-in 11.508 APE10-dist-in 5.834 APE9-dist-in 3.661 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.56 0.142 0.177 A 353 348 0 0 0 0 [[44, 298]] 1.0 5ntj Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERUA P25321 1 351 351.0 No_ligand No_ligand None DFGin 6.708 15.352 BLAminus DFGAsp-rot-in -122.01, 161.76 78.09, 83.83 205.12, -24.69 -91.35, 27.07 283.0, 77.27 -61.22, -29.16 in-none in 9.324 Saltbr-none 999.0 HRD-in -85.44, -56.28 74.88, 7.63 none-in-in SNCnii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.17, 161.42 APE9-dihe-na 121.37, -170.91 APE8-dihe-in -112.44, 135.97 APE8-rot-in 301.67 APE67-dihe-in -61.32, -23.67 -50.09, -48.07 APE12-dist-in 8.242 APE11-dist-in 11.514 APE10-dist-in 5.856 APE9-dist-in 3.626 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.15 0.207 0.245 A 353 348 1 0 0 0 [[44, 298]] 1.0 6eru Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6ERVA P25321 1 351 351.0 No_ligand No_ligand None DFGin 6.715 15.392 BLAminus DFGAsp-rot-in -125.08, 156.65 78.53, 86.88 200.46, -21.71 -92.73, 25.79 280.28, 78.54 -65.37, -20.87 in-none in 9.234 Saltbr-none 999.0 HRD-in -86.89, -53.48 76.44, 7.72 none-in-in SNCnii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.6, 158.99 APE9-dihe-na 121.28, -168.45 APE8-dihe-in -116.16, 134.01 APE8-rot-in 298.45 APE67-dihe-in -57.32, -26.83 -47.6, -49.92 APE12-dist-in 8.235 APE11-dist-in 11.488 APE10-dist-in 5.94 APE9-dist-in 3.644 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.06 0.181 0.217 A 353 341 0 0 0 0 [[44, 298]] 1.0 6erv Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y2OA P25321 1 351 351.0 O72:60406 Type1 None DFGin 6.423 14.135 BLAminus DFGAsp-rot-in -118.81, 164.94 68.54, 89.57 196.17, -4.16 -98.17, 23.6 280.79, 62.09 -51.58, -34.71 in-none in 8.664 Saltbr-none 999.0 HRD-in -99.33, -52.87 71.55, 6.25 none-in-in SNCnii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.56, 161.43 APE9-dihe-na 131.48, -155.68 APE8-dihe-in -122.0, 132.63 APE8-rot-in 297.96 APE67-dihe-in -62.6, -21.6 -48.71, -46.53 APE12-dist-in 8.147 APE11-dist-in 11.473 APE10-dist-in 5.973 APE9-dist-in 3.649 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.01 0.223 0.254 A 353 351 0 0 0 0 [[44, 298]] 1.0 6y2o Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.8e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 2OIQB P00523 258 533 533.0 No_ligand No_ligand None DFGin 6.913 15.576 BLAminus DFGAsp-rot-in -142.56, -175.83 61.81, 70.38 187.08, -62.72 -92.15, 20.71 278.09, 99.28 -54.55, -32.91 in-in in 8.301 Saltbr-in 3.439 HRD-in -88.35, -51.81 77.34, -5.91 in-in-none SNCiin in-none ActLoopNT-in 2.902 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 135.21 APE8-dihe-in -58.92, 99.35 APE8-rot-na 30.44 APE67-dihe-in -64.06, -24.16 -53.88, -29.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.765 None None None XRAY 2.07 0.232 0.263 B 286 265 11 0 0 11 [[267, 518]] 1.0 2oiq Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3EL8B P00523 256 533 533.0 No_ligand No_ligand None DFGin 6.812 15.286 BLAminus DFGAsp-rot-in -135.13, -174.74 50.6, 76.63 195.75, 3.16 -94.45, 27.76 283.26, 100.84 -52.25, -33.62 in-in in 8.385 Saltbr-in 2.842 HRD-in -86.68, -50.91 78.07, -6.49 in-in-none SNCiin in-none ActLoopNT-in 2.809 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 141.84 APE8-dihe-in -59.36, 97.16 APE8-rot-na 33.19 APE67-dihe-in -70.48, -20.47 -51.02, -25.87 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.719 None None None XRAY 2.3 0.218 0.262 B 286 259 19 0 0 13 [[267, 518]] 1.0 3el8 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 6HVEA P00523 256 533 533.0 GUW:601 Type1 None DFGin 6.556 13.854 BLAminus DFGAsp-rot-in -130.43, -171.9 51.09, 81.04 202.44, -29.7 -93.96, 22.87 297.19, 88.85 -57.14, -30.42 in-in in 7.625 Saltbr-in 2.575 HRD-in -94.1, -50.52 77.55, 0.96 in-in-none SNCiin in-none ActLoopNT-in 2.966 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 137.61 APE8-dihe-in -71.31, 110.91 APE8-rot-na 28.27 APE67-dihe-in -67.95, -34.2 -60.25, -23.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.096 T338M,S345C None None XRAY 1.9 0.178 0.203 A 286 267 11 0 0 11 [[267, 518]] 1.0 6hve Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XA P00523 255 533 533.0 IHH:1 Type1 None DFGin 6.455 14.068 BLAminus DFGAsp-rot-in -145.58, -171.22 50.93, 84.46 185.15, -60.61 -103.71, 27.02 296.31, 84.62 -56.44, -32.19 in-in in 7.775 Saltbr-in 2.792 HRD-in -87.12, -53.49 80.13, -9.7 in-in-none SNCiin in-none ActLoopNT-in 2.947 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 137.19 APE9-dihe-in -75.66, 152.05 APE8-dihe-in -49.31, 94.84 APE8-rot-na 28.47 APE67-dihe-in -60.1, -19.69 -50.76, -42.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.676 APE9-dist-na 6.248 None None None XRAY 2.35 0.234 0.266 A 286 264 15 0 0 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3F6XD P00523 257 533 533.0 IHH:1 Type1 None DFGin 6.391 14.772 BLAminus DFGAsp-rot-in -139.04, 173.47 61.43, 85.17 192.55, -14.26 -101.0, 30.99 295.99, 108.16 -61.08, -19.89 in-in in 8.602 Saltbr-in 2.872 HRD-in -82.85, -51.65 79.89, -0.15 in-in-none SNCiin in-none ActLoopNT-in 2.966 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 70.66 APE9-dihe-in -69.9, 165.23 APE8-dihe-in -59.79, 102.15 APE8-rot-na 28.02 APE67-dihe-in -64.62, -18.4 -51.92, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.772 APE9-dist-na 6.301 None None None XRAY 2.35 0.234 0.266 D 286 267 10 0 0 10 [[267, 518]] 1.0 3f6x Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4O2PB P00523 256 533 533.0 11V:601 Type1 None DFGin 6.534 14.364 BLAminus DFGAsp-rot-in -130.18, -167.75 45.02, 75.41 198.01, -19.41 -89.8, 19.65 297.38, 91.22 -55.38, -19.97 in-in in 8.19 Saltbr-in 3.223 HRD-in -85.06, -50.51 80.17, -8.96 in-in-none SNCiin in-none ActLoopNT-in 2.9 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.91 APE8-dihe-in -66.46, 102.48 APE8-rot-na 28.3 APE67-dihe-in -66.72, -24.63 -58.29, -29.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.712 None None None XRAY 2.1 0.197 0.238 B 286 265 13 0 0 12 [[267, 518]] 1.0 4o2p Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5XP7B P00523 256 533 533.0 8C6:601 Type1 None DFGin 6.645 14.268 BLAminus DFGAsp-rot-in -134.44, -176.16 50.89, 76.48 191.19, 5.98 -90.12, 24.26 289.46, 88.6 -62.66, -19.97 in-in in 8.286 Saltbr-in 3.224 HRD-in -90.41, -49.69 74.77, 0.35 in-in-none SNCiin in-none ActLoopNT-in 2.978 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.58 APE8-dihe-in -67.72, 110.71 APE8-rot-na 25.27 APE67-dihe-in -70.91, -25.72 -56.94, -25.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.069 None None None XRAY 2.012 0.169 0.198 B 286 267 11 0 0 11 [[267, 518]] 1.0 5xp7 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 4MCVA P00523 256 533 533.0 29K:601 Type1 None DFGin 6.255 14.18 BLAminus DFGAsp-rot-in -139.77, -175.96 57.49, 90.62 189.12, -88.18 -111.94, 64.22 308.36, 94.27 -85.67, 117.17 in-in in 7.676 Saltbr-in 3.59 HRD-in -94.67, -38.67 68.11, -0.39 in-in-none SNCiin in-none ActLoopNT-in 3.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 102.41 APE8-dihe-in -74.67, 65.8 APE8-rot-na 28.47 APE67-dihe-in -64.37, -31.73 -64.06, -34.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.578 T338G None None XRAY 2.73 0.243 0.29 A 278 267 11 0 0 11 [[267, 518]] 1.0 4mcv Gallus gallus TYR_SRC_CHICK TYR 2.6e-93 318.0 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3G5DA P00523 257 533 533.0 1N1:1 Type1.5_Back None DFGin 6.719 14.175 BLAminus DFGAsp-rot-in -122.29, -173.62 52.53, 77.9 199.96, -25.62 -96.14, 20.03 300.27, 89.98 -55.15, -32.52 in-in in 8.226 Saltbr-in 3.471 HRD-in -89.79, -51.87 81.03, -11.33 in-in-none SNCiin in-none ActLoopNT-in 3.185 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.62 APE8-dihe-in -62.24, 114.12 APE8-rot-na 23.22 APE67-dihe-in -69.68, -25.09 -60.39, -25.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.756 S345C None None XRAY 2.2 0.207 0.257 A 286 256 21 0 0 13 [[267, 518]] 1.0 3g5d Gallus gallus TYR_SRC_CHICK TYR 4.6e-94 320.5 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC PRKCI KPCI_MOUSE 4DC2A Q62074 248 586 595.0 ADE:60601 Type1 None DFGin 5.514 11.595 BLAminus DFGAsp-rot-in -116.21, -173.67 60.87, 97.17 203.3, -17.4 -103.56, 4.24 303.35, 138.78 -42.92, -43.52 in-none in 9.099 Saltbr-none 999.0 HRD-in -77.29, -48.77 70.59, -5.86 none-in-in SNCnii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.58, 165.79 APE9-dihe-na 134.32, -165.14 APE8-dihe-in -104.82, 125.13 APE8-rot-in 306.69 APE67-dihe-in -51.64, -27.58 -50.63, -43.23 APE12-dist-in 8.611 APE11-dist-in 11.606 APE10-dist-in 6.22 APE9-dist-in 3.688 None TPO563 TPO563 XRAY 2.4 0.176 0.241 A 396 329 10 0 0 0 [[253, 521]] 1.0 4dc2 Mus musculus AGC_PRKCI_MOUSE AGC 1.2e-94 322.3 1 260 260 394 395 396 398 400 282 301 305 374 376 375 377 434 422 417 416 415 414 413 412 411 332 Protein kinase C iota type
CAMK MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.712 14.57 BLAminus DFGAsp-rot-in -130.6, -176.06 61.21, 74.64 210.74, 7.94 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.847 Saltbr-in 2.958 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.443 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334 308 17 0 0 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.4e-88 301.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_MOUSE 4CQGA Q61846 2 326 643.0 OT5:61332 Type1 None DFGin 6.312 14.194 BLAminus DFGAsp-rot-in -132.87, 178.1 63.59, 73.65 223.43, -34.48 -97.71, 18.69 288.44, 92.66 -66.54, -24.22 in-in in 9.21 Saltbr-in 3.071 HRD-in -69.96, -53.3 76.88, 4.58 in-in-none SNCiin in-none ActLoopNT-in 2.962 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 156.81 APE9-dihe-na 87.85, 175.2 APE8-dihe-in -57.99, 138.67 APE8-rot-in 288.02 APE67-dihe-in -62.14, -25.5 -62.1, -43.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 5.7 APE9-dist-in 3.91 T167E None None XRAY 2.57 0.207 0.251 A 331 308 17 0 0 12 [[11, 263]] 1.0 4cqg Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CMGC MAPK14 MK14_MOUSE 5NZZH P47811 5 352 360.0 AGS:60500 ATPlike None DFGin 6.52 14.912 BLAminus DFGAsp-rot-in -107.76, 173.34 60.28, 95.29 194.35, -27.89 -107.52, 29.84 280.25, 79.55 -61.87, -24.37 in-none in 9.249 Saltbr-none 999.0 HRD-in -88.17, -55.8 88.26, -17.82 none-in-in SNCnii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.4, 153.2 APE9-dihe-na 72.78, 157.17 APE8-dihe-in -63.99, 158.8 APE8-rot-in 301.47 APE67-dihe-in -70.1, -20.58 -71.77, -51.25 APE12-dist-in 12.048 APE11-dist-in 11.371 APE10-dist-in 7.651 APE9-dist-in 3.35 None TPO180,PTR182 TPO180,PTR182 XRAY 2.6 0.221 0.271 H 360 337 9 0 0 0 [[24, 308]] 1.0 5nzz Mus musculus CMGC_MAPK14_MOUSE CMGC 2e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TKL RIPK3 RIPK3_MOUSE 4M66B Q9QZL0 14 313 486.0 No_ligand No_ligand None DFGin 6.257 13.906 BLAminus DFGAsp-rot-in -131.04, 173.42 61.1, 97.0 189.32, 12.92 -115.48, 32.44 299.35, 93.88 -64.23, -38.27 in-in in 8.429 Saltbr-in 2.396 HRD-in -76.55, -48.31 73.84, -8.87 in-in-none SNCiin in-none ActLoopNT-in 2.49 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -70.87, -4.86 999.0, -21.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C111A None None XRAY 2.401 0.217 0.258 B 325 265 35 0 0 19 [[20, 290]] 1.0 4m66 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX2B Q9QZL0 13 313 486.0 No_ligand No_ligand None DFGin 6.33 13.859 BLAminus DFGAsp-rot-in -148.46, -178.51 60.6, 72.26 194.1, 4.98 -92.16, 23.07 300.89, 97.28 -69.06, -26.68 in-in in 8.252 Saltbr-in 2.687 HRD-in -69.09, -48.01 69.12, -1.67 in-in-none SNCiin in-none ActLoopNT-in 2.774 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.27 APE8-rot-in 299.69 APE67-dihe-in -70.84, -21.22 -92.23, 4.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.39 0.23 0.276 B 325 264 37 0 0 19 [[20, 290]] 1.0 9ix2 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX0A Q9QZL0 15 312 486.0 A1D99:401 Type1 None DFGin 6.175 14.031 BLAminus DFGAsp-rot-in -143.29, 171.72 60.25, 76.29 197.6, -6.62 -91.31, 27.47 299.18, 101.06 -70.53, -25.92 in-in in 8.508 Saltbr-in 2.757 HRD-in -63.18, -53.03 70.09, 0.01 in-in-none SNCiin in-none ActLoopNT-in 2.729 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -148.23 APE8-dihe-in -50.23, 128.69 APE8-rot-in 297.82 APE67-dihe-in -60.6, -26.4 -69.61, -32.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.583 None None None XRAY 2.1 0.205 0.243 A 325 269 29 0 0 17 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX0B Q9QZL0 13 311 486.0 A1D99:401 Type1 None DFGin 6.254 13.905 BLAminus DFGAsp-rot-in -148.35, -179.19 58.25, 77.83 194.68, -1.84 -96.97, 28.2 308.45, 66.53 -68.51, -30.59 in-in in 8.662 Saltbr-in 3.043 HRD-in -69.9, -51.03 76.13, -3.93 in-in-none SNCiin in-none ActLoopNT-in 2.728 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -72.8 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.86 -71.87, -10.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.1 0.205 0.243 B 325 255 44 0 0 19 [[20, 290]] 1.0 9ix0 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IX1A Q9QZL0 15 313 486.0 PP2:60401 Type1 None DFGin 5.913 14.386 BLAminus DFGAsp-rot-in -149.4, 179.25 53.78, 84.76 202.16, -25.4 -98.68, 28.86 296.35, 93.86 -68.88, -29.86 in-in in 8.49 Saltbr-in 2.82 HRD-in -73.45, -52.59 70.92, 5.37 in-in-none SNCiin in-none ActLoopNT-in 2.862 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.32, -23.19 999.0, 1.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.31 0.221 0.255 A 325 268 31 0 0 19 [[20, 290]] 1.0 9ix1 Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVGA Q9QZL0 14 312 486.0 LKR:401 Type1 None DFGin 5.994 13.863 BLAminus DFGAsp-rot-in -143.57, 178.7 54.72, 82.38 196.27, -9.99 -98.67, 31.08 302.44, 93.08 -71.32, -23.61 in-in in 8.503 Saltbr-in 2.534 HRD-in -71.75, -46.38 68.0, 5.54 in-in-none SNCiin in-none ActLoopNT-in 2.84 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.4 APE8-rot-none 999.0 APE67-dihe-in -65.94, -24.52 -63.59, -34.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 A 325 268 31 0 0 18 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVGB Q9QZL0 14 311 486.0 LKR:401 Type1 None DFGin 6.084 13.882 BLAminus DFGAsp-rot-in -141.96, 177.06 54.0, 89.88 198.27, -8.41 -106.67, 29.11 304.14, 81.96 -69.4, -38.51 in-in in 8.544 Saltbr-in 2.772 HRD-in -66.91, -46.81 64.26, 6.52 in-in-none SNCiin in-none ActLoopNT-in 2.685 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.66, -18.61 999.0, 5.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.03 0.218 0.236 B 325 250 48 0 0 19 [[20, 290]] 1.0 9lvg Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.25 14.259 BLAminus DFGAsp-rot-in -136.98, 168.96 62.75, 89.32 198.72, 4.07 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.376 Saltbr-in 2.879 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325 263 37 0 0 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.144 14.058 BLAminus DFGAsp-rot-in -139.36, 174.01 57.76, 83.37 192.45, 4.04 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.581 Saltbr-in 2.817 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325 266 34 0 0 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IWWA Q9QZL0 13 312 486.0 A1D96:401 Type1.5_Back None DFGin 5.986 13.437 BLAminus DFGAsp-rot-in -144.16, 173.05 63.98, 84.62 200.57, -26.53 -101.11, 24.14 300.74, 93.26 -71.71, -26.9 in-in in 8.088 Saltbr-in 2.888 HRD-in -71.21, -48.68 73.29, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.715 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -153.01 APE9-dihe-na 106.36, 163.97 APE8-dihe-in -82.15, 128.32 APE8-rot-in 297.93 APE67-dihe-in -63.89, -25.3 -71.15, -26.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.411 APE9-dist-in 5.408 None None None XRAY 1.93 0.183 0.209 A 325 284 16 0 0 16 [[20, 290]] 1.0 9iww Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IWZA Q9QZL0 13 312 486.0 ZOV:401 Type1.5_Back None DFGin 6.167 13.332 BLAminus DFGAsp-rot-in -140.79, 171.83 65.16, 90.29 193.53, -12.4 -104.26, 18.26 298.04, 95.08 -65.53, -28.75 in-in in 7.87 Saltbr-in 2.858 HRD-in -70.03, -51.19 78.93, -3.69 in-in-none SNCiin in-none ActLoopNT-in 2.767 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, -29.88 APE9-dihe-na 105.08, -174.88 APE8-dihe-in -93.5, 124.97 APE8-rot-in 297.04 APE67-dihe-in -65.66, -19.22 -68.64, -29.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.387 APE9-dist-in 5.623 None None None XRAY 1.82 0.178 0.211 A 325 285 15 0 0 15 [[20, 290]] 1.0 9iwz Mus musculus TKL_RIPK3_MOUSE TKL 5.1e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9IWXA Q9QZL0 14 311 486.0 A1D96:401 Type1.5_Back None DFGin 6.485 13.836 BLAminus DFGAsp-rot-in -139.34, 174.94 62.89, 84.12 206.04, -33.2 -98.91, 17.96 292.01, 88.18 -69.55, -33.91 in-in in 8.085 Saltbr-in 2.79 HRD-in -70.26, -48.65 73.87, -6.66 in-in-none SNCiin in-none ActLoopNT-in 2.711 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 126.28 APE8-rot-in 301.73 APE67-dihe-in -62.28, -24.57 -68.16, -31.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R69H None None XRAY 1.99 0.189 0.236 A 325 280 18 0 0 18 [[20, 290]] 1.0 9iwx Mus musculus TKL_RIPK3_MOUSE TKL 8e-60 208.6 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHB2 EPHB2_MOUSE 2HENA P54763 614 893 986.0 ADP:60400 ATPlike None DFGin 5.333 15.674 BLAminus DFGAsp-rot-in -133.74, -165.91 59.29, 70.83 179.59, 55.25 -103.82, 9.51 292.63, 82.7 -87.21, 999.0 in-in in 8.023 Saltbr-in 2.786 HRD-in -62.88, -49.36 74.49, -21.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.77 APE8-rot-na 327.53 APE67-dihe-in -57.52, -8.41 -44.64, -64.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 A 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENB P54763 614 893 986.0 ADP:60401 ATPlike None DFGin 4.876 14.888 BLAminus DFGAsp-rot-in -140.27, -169.83 69.21, 92.69 197.67, -65.34 -125.5, 35.8 302.49, 84.21 -59.5, 999.0 in-in in 8.267 Saltbr-in 2.839 HRD-in -71.96, -52.85 76.51, -19.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.95 APE8-rot-na 35.68 APE67-dihe-in -63.04, 8.29 -53.0, -58.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 B 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENC P54763 614 893 986.0 ADP:60402 ATPlike None DFGin 5.167 15.787 BLAminus DFGAsp-rot-in -136.6, -161.63 61.14, 70.93 183.58, 55.66 -108.31, 8.65 286.35, 98.46 -79.82, 999.0 in-in in 8.074 Saltbr-in 2.876 HRD-in -60.04, -43.18 71.33, -24.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.37 APE8-rot-na 329.62 APE67-dihe-in -67.84, -7.2 -58.96, -40.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 C 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HEND P54763 614 893 986.0 ADP:60403 ATPlike None DFGin 4.79 14.772 BLAminus DFGAsp-rot-in -150.33, -176.71 75.96, 94.04 193.06, -64.19 -126.18, 89.85 307.58, 79.07 -67.67, 999.0 in-in in 8.322 Saltbr-in 3.409 HRD-in -71.43, -49.79 75.74, -24.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.49 APE8-rot-na 333.13 APE67-dihe-in -68.61, 6.13 -48.05, -54.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 D746A None None XRAY 2.6 0.205 0.26 D 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7.2e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
OTHER PKNB PKNB_MYCTU 1O6YA P9WI81 3 278 626.0 ACP:1279 ATPlike None DFGin 5.309 14.78 BLAminus DFGAsp-rot-in -139.04, -177.54 67.82, 83.57 189.66, -2.53 -97.92, 24.81 285.65, 79.79 -51.43, -35.15 in-in in 8.242 Saltbr-in 2.792 HRD-in -70.46, -52.6 71.79, -5.94 in-in-none SNCiin in-none ActLoopNT-in 2.752 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -69.25, -16.6 999.0, -48.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.193 0.23 A 299 260 16 0 0 16 [[11, 273]] 1.0 1o6y Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 6.6e-46 162.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
CMGC MAPK1 MK01_RAT 3C9WA P63086 6 354 358.0 HMY:1 Type1 None DFGin 6.999 15.702 BLAminus DFGAsp-rot-in -123.81, 173.38 50.82, 89.77 192.89, 14.29 -103.35, 17.03 287.88, 69.21 -57.05, -26.18 in-in in 9.643 Saltbr-in 2.694 HRD-in -68.6, -50.76 75.06, -2.41 in-in-none SNCiin in-none ActLoopNT-in 2.74 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.03 APE8-rot-in 303.8 APE67-dihe-in -65.62, -21.36 -55.58, -26.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.5 0.197 0.274 A 357 336 13 0 0 13 [[23, 311]] 1.0 3c9w Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.2 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
TYR CSK CSK_RAT 1K9AA P32577 6 450 450.0 No_ligand No_ligand None DFGin 7.025 13.118 BLAminus DFGAsp-rot-in -139.67, -167.82 53.56, 74.8 198.77, -39.15 -92.76, 23.85 306.26, 90.9 -52.74, -52.0 in-in in 8.261 Saltbr-in 2.543 HRD-in -75.98, -39.34 59.35, 3.94 in-in-none SNCiin in-none ActLoopNT-in 2.904 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 146.13 APE9-dihe-in -90.54, 133.78 APE8-dihe-in -64.01, 107.63 APE8-rot-na 30.9 APE67-dihe-in -66.63, -13.65 -46.3, -47.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.896 APE9-dist-na 4.946 None None None XRAY 2.5 0.246 0.288 A 450 439 6 0 0 6 [[195, 442]] 1.0 1k9a Rattus norvegicus TYR_CSK_RAT TYR 8.1e-87 297.0 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
CK1 HRR25 HRR25_YEAST 5CYZA P29295 1 388 494.0 No_ligand No_ligand None DFGin 6.229 15.334 BLAminus DFGAsp-rot-in -128.54, 179.51 66.19, 80.02 198.72, -10.94 -99.63, 19.66 287.65, 84.23 -59.34, -31.87 in-none in 8.328 Saltbr-none 999.0 HRD-in -79.26, -49.66 70.34, 12.02 none-in-in SNCnii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.13, -20.75 APE9-dihe-na -89.87, -152.56 APE8-dihe-in -86.32, 132.66 APE8-rot-in 308.22 APE67-dihe-in -57.09, -35.6 -67.98, -36.78 APE12-dist-in 11.78 APE11-dist-in 11.968 APE10-dist-in 6.445 APE9-dist-in 4.264 K38R None MLY8,MLY14,MLY130,MLY154,MLY155,MLY171,MLY222,MLY231,MLY256,MLY263,MLY274,MLY279,MLY335,MLY337,MLY352,MLY365 XRAY 1.841 0.165 0.192 A 395 368 0 0 0 0 [[9, 275]] 1.0 5cyz Saccharomyces cerevisiae CK1_HRR25_YEAST CK1 9.8e-102 346.0 1 261 261 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I homolog HRR25
CMGC FUS3 FUS3_YEAST 2F9GA P16892 1 353 353.0 ADP:500 ATPlike None DFGin 6.607 14.033 BLAminus DFGAsp-rot-in -131.87, -173.96 62.19, 67.37 224.02, -8.11 -94.01, 7.54 292.42, 102.61 -61.43, -28.32 in-in in 8.738 Saltbr-in 2.766 HRD-in -77.05, -50.83 75.67, -3.23 in-in-none SNCiin in-none ActLoopNT-in 2.955 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.43 APE8-rot-in 296.4 APE67-dihe-in -62.22, -26.66 -58.62, -16.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR182 PTR182 XRAY 2.1 0.211 0.26 A 353 332 21 0 0 21 [[13, 309]] 1.0 2f9g Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.3e-75 258.5 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
OTHER BUD32 BUD32_YEAST 4WWAA P53323 4 253 261.0 No_ligand No_ligand None DFGin 6.819 15.236 BLAminus DFGAsp-rot-in -144.51, 174.66 32.61, 87.29 185.86, 52.44 -96.28, 31.48 285.55, 91.16 -60.3, -51.25 in-none in 7.46 Saltbr-none 999.0 HRD-in -77.93, -56.43 73.9, 41.54 none-in-na SNCnia in-na ActLoopNT-in 2.562 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -65.7, -37.17 APE9-dihe-na -68.09, -40.47 APE8-dihe-na -61.67, -53.02 APE8-rot-na 213.04 APE67-dihe-na -52.82, -48.51 -50.09, -51.8 APE12-dist-na 16.267 APE11-dist-na 11.778 APE10-dist-na 15.171 APE9-dist-na 12.257 None None None XRAY 2.953 0.221 0.296 A 261 224 34 0 0 0 [[17, 261]] 1.0 4wwa Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5.2e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER IRE1 IRE1_YEAST 2RIOA P32361 665 1115 1115.0 ADP:61101 ATPlike None DFGin 5.032 14.666 BLAminus DFGAsp-rot-in -125.01, -166.82 59.91, 72.41 199.47, -11.39 -79.74, 13.1 278.94, 57.84 -50.86, -29.29 out-in out 10.36 Saltbr-in 3.544 HRD-in -69.38, -55.95 80.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.684 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.77 APE8-rot-in 240.38 APE67-dihe-in -59.81, -10.2 -102.36, 14.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 A 434 396 26 0 0 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0A P32361 665 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.657 14.52 BLAminus DFGAsp-rot-in -127.75, -159.8 55.73, 76.2 196.46, -18.32 -100.97, 26.65 278.19, 55.54 -68.42, -38.12 in-in in 9.315 Saltbr-in 3.043 HRD-in -75.54, -40.03 69.65, -11.03 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.99 APE8-rot-none 999.0 APE67-dihe-in -81.59, -8.09 -104.48, 18.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 A 434 407 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0B P32361 670 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.639 14.529 BLAminus DFGAsp-rot-in -127.76, -160.17 56.44, 75.29 195.96, -17.67 -99.49, 26.48 278.86, 54.86 -67.91, -37.63 in-in in 9.332 Saltbr-in 3.088 HRD-in -76.48, -40.82 70.18, -10.34 in-in-none SNCiin in-none ActLoopNT-in 2.864 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.45 APE8-rot-in 292.53 APE67-dihe-in -81.7, -8.3 -104.03, 18.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 B 434 402 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ1A P32361 665 1115 1115.0 DKI:1 Type1 None DFGin 5.549 14.198 BLAminus DFGAsp-rot-in -134.05, -172.29 64.43, 86.72 195.45, -16.5 -105.73, 31.33 281.55, 58.87 -71.4, -43.5 in-in in 9.069 Saltbr-in 2.771 HRD-in -75.98, -46.34 75.54, -5.83 in-in-none SNCiin in-none ActLoopNT-in 2.858 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -47.95 APE8-rot-none 999.0 APE67-dihe-in -76.17, -21.3 -105.55, 30.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.264 0.284 A 434 407 20 0 0 7 [[672, 977]] 1.0 3lj1 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ1B P32361 665 1115 1115.0 DKI:1 Type1 None DFGin 5.566 14.194 BLAminus DFGAsp-rot-in -134.95, -174.09 65.23, 87.06 196.07, -14.43 -105.31, 31.78 281.4, 59.08 -71.99, -43.07 in-in in 9.066 Saltbr-in 2.849 HRD-in -76.02, -48.57 76.62, -4.7 in-in-none SNCiin in-none ActLoopNT-in 2.883 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -48.69 APE8-rot-none 999.0 APE67-dihe-in -76.4, -21.31 -105.99, 30.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.33 0.264 0.284 B 434 407 20 0 0 7 [[672, 977]] 1.0 3lj1 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1.1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ROP18 ROP18_TOXGO 4JRNA Q2PAY2 187 548 554.0 ANP:601 Allosteric None DFGin 8.982 15.869 BLAminus DFGAsp-rot-in -128.68, -167.44 58.76, 57.13 201.11, 49.38 -87.53, 25.8 281.08, 82.06 -67.92, -21.93 in-in in 8.183 Saltbr-in 2.992 HRD-in -70.13, -31.0 63.02, -2.32 in-in-none SNCiin in-none ActLoopNT-in 2.384 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.51 APE8-dihe-in -78.23, 127.04 APE8-rot-in 289.7 APE67-dihe-inflip 110.21, -8.27 -63.71, 127.69 APE12-dist-in 10.007 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None None None XRAY 2.71 0.235 0.289 A 372 349 6 0 0 2 [[253, 531]] 1.0 4jrn Toxoplasma gondii OTHER_ROP18_TOXGO CAMK 0.041 76.6 5 55 197 426 427 428 430 432 281 300 304 406 408 407 409 465 450 445 444 443 442 441 440 439 0 Serine/threonine-protein kinase ROP18