4M69

MLKL (Mixed lineage kinase domain-like protein)
RIPK3 (Receptor-interacting serine/threonine-protein kinase 3)
Pseudokinase
Group: OTHER TKL
Uniprot: RIPK3_MOUSE MLKL_MOUSE
Organism: Mus musculus
Domain boundary: 22 - 290 190 - 455
Resolution: 2.497

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A TKL RIPK3 RIPK3_MOUSE Receptor-interacting serine/threonine-protein kinase 3 Mus musculus Inactive DFGin BLBplus out-out out-out ANP Type1 12 - 312 14
B OTHER MLKL MLKL_MOUSE Mixed lineage kinase domain-like protein Mus musculus Inactive None None out-out out-out No_ligand No_ligand 182 - 466 13
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
       191        201        211        221 
QIKEIPKEHL GPPWTKLKTS KMSTIYRGEY HRSPVTIKVF 
       231        241        251        261 
NNPQAESVGI VRFTFNDEIK TMKKFDSPNI LRIFGICIDQ 
       271        281        291        301 
TVKPPEFSIV MEYCELGTLR ELLDREKDLT MSVRSLLVLR 
       311        321        331        341 
AARGLYRLHH SETLHRNISS SSFLVAGGYQ VKLAGFELSK 
       351        361        371        381 
TQNsisrtak stkaerSSST IYVSPERLKN PFCLYDIKAE 
       391        401        411        421 
IYSFGIVLWE IATGKIPFEG CDSKKIRELV AEDKKQEPVG 
       431        441        459        469 
QDCPELLREI INECRAHEPS QRPSVDGILE RLSAVEEstd 

kkv
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None