3K3I

MAPK14 (Mitogen-activated protein kinase 14)
Group: CMGC
Uniprot: MK14_HUMAN
Organism: Homo sapiens
Domain boundary: 24 - 308
Resolu: 1.7

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGout BBAminus in-in none-out JZJ I46 I46 Type3 Allosteric Allosteric 5 - 352 12
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain A
        12         22         32         42 
gsRPTFYRQE LNKTIWEVPE RYQNLSPVGS GAYGSVCAAF 
        52         62         72         82 
DTKTGLRVAV KKLSRPFQSI IHAKRTYREL RLLKHMKHEN 
        92        102        112        122 
VIGLLDVFTP ARSLEEFNDV YLVTHLMGAD LNNIvkcqKL 
       132        142        152        162 
TDDHVQFLIY QILRGLKYIH SADIIHRDLK PSNLAVNEDC 
       172        182        192        202 
ELKILDFGla rhtddemtgy VATRWYRAPE IMLNWMHYNQ 
       212        222        232        242 
TVDIWSVGCI MAELLTGRTL FPGTDHIDQL KLILRLVGTP 
       252        262        272        282 
GAELLKKISS ESARNYIQSL TQMPKMNFAN VFIGANPLAV 
       292        302        312        322 
DLLEKMLVLD SDKRITAAQA LAHAYFAQYH DPDDEPVADP 
       332        342        352 
YDQSFESRDL LIDEWKSLTY DEVISFVPPP
Lower-case residues are disordered in structure.
Mutations: None
Phosphorylation: None