PLK1 (Serine/threonine-protein kinase PLK1)

Group: CAMK
Uniprot: PLK1_HUMAN
Domain boundary: 53 - 305


Total number of chains: 18
Spatial Dihedral Chains Representative
DFGin BLAminus 18 AF-P53350-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P53350-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 45 - 313 None None 0
2V5QA 2.3 Inactive DFGin BLAminus out-in in-out No_ligand No_ligand 39 - 323 None None 0
2V5QB 2.3 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 39 - 323 None None 0
2YACA 2.2 Inactive DFGin BLAminus in-in in-out 937 Type1 39 - 329 None None 0
3KB7A 2.5 Inactive DFGin BLAminus in-in in-out 071 Type1 39 - 328 None None 0
4A4LA 2.35 Inactive DFGin BLAminus in-in in-out 939 Type1 39 - 329 None None 0
4A4OA 2.7 Inactive DFGin BLAminus in-in in-out 664 Type1 39 - 329 None None 0
4J52A 2.3 Inactive DFGin BLAminus in-in in-out 1J3 Type1 38 - 330 T210V None 0
4J53A 2.5 Inactive DFGin BLAminus in-in in-out 1J4 Type1 38 - 330 T210V None 0
2RKUA 1.95 Inactive DFGin BLAminus in-in in-out R78 Type1 37 - 330 T210V None 0
8BJTA 2.188 Inactive DFGin BLAminus in-in in-out 8X7 Type1 39 - 330 None None 0
3THBA 2.5 Inactive DFGin BLAminus in-in in-out 3TA Type1 42 - 328 T210V None 0
8X72A 2.2 Inactive DFGin BLAminus out-in in-out ANP Type1 37 - 330 None None 0
2OU7A 2.4 Inactive DFGin BLAminus out-in in-out ANP Type1 37 - 328 T210V None 0
2OWBA 2.1 Inactive DFGin BLAminus in-in in-out 626 Type1 37 - 330 T210V None 0
3FC2A 2.45 Inactive DFGin BLAminus in-in in-out IBI Type1 37 - 329 T210V None 0
5TA6A 2.5 Inactive DFGin BLAminus in-in in-out 79D Type1 37 - 330 None None 0
5TA8A 2.6 Inactive DFGin BLAminus in-in in-out 79C Type1 37 - 330 None None 0

PLK1 (Serine/threonine-protein kinase PLK1)

Group: CAMK
Total number of chains: 30
Spatial Dihedral Chains Representative
DFGin BLAminus 29 AF-P53350-K1A
DFGin ABAminus 1 4J7BD
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Danio rerio Q6DRK7_DANRE 4J7BD 2.3 Inactive DFGin ABAminus out-in in-out No_ligand No_ligand 20 - 311 D162N,E192F None 11
Danio rerio Q6DRK7_DANRE 3D5UA 2.8 Inactive DFGin BLAminus out-out in-out No_ligand No_ligand 23 - 310 None None 0
Danio rerio Q6DRK7_DANRE 3D5VA 2.4 None DFGin BLAminus out-in in-none No_ligand No_ligand 25 - 312 T196D None 19
Danio rerio Q6DRK7_DANRE 4J7BA 2.3 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 18 - 311 D162N,E192F None 10
Danio rerio Q4KMI8_DANRE 3D5WA 2.6 Inactive DFGin BLAminus out-out in-in ADP Type1 24 - 310 None X196 0
Danio rerio Q4KMI8_DANRE 3D5XA 2.8 None DFGin BLAminus out-out in-none KWT Type1 24 - 309 T196D None 7
Danio rerio Q4KMI8_DANRE 3DBEA 3.32 None DFGin BLAminus out-out in-none 4FR Type1 24 - 310 T196D None 3
Danio rerio Q4KMI8_DANRE 3DBFA 3.2 None DFGin BLAminus in-out in-none 5FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DB8A 3.15 None DFGin BLAminus in-out in-none 1FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DBCA 3.35 None DFGin BLAminus in-out in-none 2FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DBDA 3.05 None DFGin BLAminus out-out in-none 3FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DB6A 2.85 Inactive DFGin BLAminus out-out in-out FRS Type1.5_Front 24 - 310 T196D None 0
Homo sapiens PLK1_HUMAN AF-P53350-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 45 - 313 None None 0
Homo sapiens PLK1_HUMAN 2V5QA 2.3 Inactive DFGin BLAminus out-in in-out No_ligand No_ligand 39 - 323 None None 0
Homo sapiens PLK1_HUMAN 2V5QB 2.3 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 39 - 323 None None 0
Homo sapiens PLK1_HUMAN 2YACA 2.2 Inactive DFGin BLAminus in-in in-out 937 Type1 39 - 329 None None 0
Homo sapiens PLK1_HUMAN 3KB7A 2.5 Inactive DFGin BLAminus in-in in-out 071 Type1 39 - 328 None None 0
Homo sapiens PLK1_HUMAN 4A4LA 2.35 Inactive DFGin BLAminus in-in in-out 939 Type1 39 - 329 None None 0
Homo sapiens PLK1_HUMAN 4A4OA 2.7 Inactive DFGin BLAminus in-in in-out 664 Type1 39 - 329 None None 0
Homo sapiens PLK1_HUMAN 4J52A 2.3 Inactive DFGin BLAminus in-in in-out 1J3 Type1 38 - 330 T210V None 0
Homo sapiens PLK1_HUMAN 4J53A 2.5 Inactive DFGin BLAminus in-in in-out 1J4 Type1 38 - 330 T210V None 0
Homo sapiens PLK1_HUMAN 2RKUA 1.95 Inactive DFGin BLAminus in-in in-out R78 Type1 37 - 330 T210V None 0
Homo sapiens PLK1_HUMAN 8BJTA 2.188 Inactive DFGin BLAminus in-in in-out 8X7 Type1 39 - 330 None None 0
Homo sapiens PLK1_HUMAN 3THBA 2.5 Inactive DFGin BLAminus in-in in-out 3TA Type1 42 - 328 T210V None 0
Homo sapiens PLK1_HUMAN 8X72A 2.2 Inactive DFGin BLAminus out-in in-out ANP Type1 37 - 330 None None 0
Homo sapiens PLK1_HUMAN 2OU7A 2.4 Inactive DFGin BLAminus out-in in-out ANP Type1 37 - 328 T210V None 0
Homo sapiens PLK1_HUMAN 2OWBA 2.1 Inactive DFGin BLAminus in-in in-out 626 Type1 37 - 330 T210V None 0
Homo sapiens PLK1_HUMAN 3FC2A 2.45 Inactive DFGin BLAminus in-in in-out IBI Type1 37 - 329 T210V None 0
Homo sapiens PLK1_HUMAN 5TA6A 2.5 Inactive DFGin BLAminus in-in in-out 79D Type1 37 - 330 None None 0
Homo sapiens PLK1_HUMAN 5TA8A 2.6 Inactive DFGin BLAminus in-in in-out 79C Type1 37 - 330 None None 0

PLK1 (Serine/threonine-protein kinase PLK1)

Group: CAMK
Total number of chains: 12
Spatial Dihedral Chains Representative
DFGin BLAminus 11 3D5UA
DFGin ABAminus 1 4J7BD
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Danio rerio Q6DRK7_DANRE 4J7BD 2.3 Inactive DFGin ABAminus out-in in-out No_ligand No_ligand 20 - 311 D162N,E192F None 11
Danio rerio Q6DRK7_DANRE 3D5UA 2.8 Inactive DFGin BLAminus out-out in-out No_ligand No_ligand 23 - 310 None None 0
Danio rerio Q6DRK7_DANRE 3D5VA 2.4 None DFGin BLAminus out-in in-none No_ligand No_ligand 25 - 312 T196D None 19
Danio rerio Q6DRK7_DANRE 4J7BA 2.3 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 18 - 311 D162N,E192F None 10
Danio rerio Q4KMI8_DANRE 3D5WA 2.6 Inactive DFGin BLAminus out-out in-in ADP Type1 24 - 310 None X196 0
Danio rerio Q4KMI8_DANRE 3D5XA 2.8 None DFGin BLAminus out-out in-none KWT Type1 24 - 309 T196D None 7
Danio rerio Q4KMI8_DANRE 3DBEA 3.32 None DFGin BLAminus out-out in-none 4FR Type1 24 - 310 T196D None 3
Danio rerio Q4KMI8_DANRE 3DBFA 3.2 None DFGin BLAminus in-out in-none 5FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DB8A 3.15 None DFGin BLAminus in-out in-none 1FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DBCA 3.35 None DFGin BLAminus in-out in-none 2FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DBDA 3.05 None DFGin BLAminus out-out in-none 3FR Type1 24 - 310 T196D None 20
Danio rerio Q4KMI8_DANRE 3DB6A 2.85 Inactive DFGin BLAminus out-out in-out FRS Type1.5_Front 24 - 310 T196D None 0