NEK2 (Serine/threonine-protein kinase Nek2)

Group: NEK
Uniprot: NEK2_HUMAN
Domain boundary: 8 - 271


Total number of chains: 30
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P51955-K1A
DFGin BLBminus 1 5M53A
DFGin None 5 5M51A
DFGinter None 2 2W5BA
DFGout None 6 2XNPA
None None 15 2W5AA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P51955-K1A -1.0 Active DFGin BLAminus out-in in-in No_ligand No_ligand 1 - 279 None None 0
5M53A 1.9 Inactive DFGin BLBminus out-out none-out 7GJ Type1 7 - 271 None None 14
2XKDA 1.96 Inactive DFGin None out-out none-none T3M Type1 3 - 271 None None 14
2XKEA 2.203 Inactive DFGin None out-out none-none WI2 Type1 3 - 271 None None 18
2XKFA 2.35 Inactive DFGin None out-out none-out BX1 Type1 3 - 271 None None 15
5M51A 1.899 Inactive DFGin None out-none none-out NU6 Type1 3 - 271 None None 16
5M57A 2.3 Inactive DFGin None out-none none-out 4SP Type1 3 - 271 None None 16
2W5HA 2.33 Inactive DFGinter None out-none none-out No_ligand No_ligand 3 - 271 T175A None 3
2W5BA 2.4 Inactive DFGinter None out-out out-out AGS Type1 3 - 271 T175A None 0
2XK3A 2.2 Inactive DFGout None out-out none-out XK3 Type1 3 - 271 None None 15
2XK4A 2.1 Inactive DFGout None out-out none-out OL2 Type1 3 - 271 None None 13
2XK8A 2.001 Inactive DFGout None out-out none-out 5R1 Type1 3 - 271 None None 15
2XNPA 1.98 Inactive DFGout None out-out none-out WCX Type1 3 - 271 None None 13
4AFEA 2.597 Inactive DFGout None out-out none-out GGY Type1 3 - 271 None None 14
4A4XA 2.4 Inactive DFGout None out-out none-out JUP Type1 3 - 271 T170E,S171D,T175E None 14
2W5AA 1.55 Inactive None None out-out out-out ADP Type1 3 - 271 None None 3
2WQOA 2.167 Inactive None None out-out none-none VGK Type1 3 - 271 None None 18
2XK6A 2.2 Inactive None None out-out none-out EQH Type1 4 - 271 None None 17
2XK7A 1.992 Inactive None None out-out none-out 30E Type1 3 - 271 None None 16
2XKCA 2.5 Inactive None None out-none none-none 4VQ Type1 3 - 271 None None 18
2XNMA 1.85 Inactive None None out-out none-out WGZ Type1 3 - 271 None None 9
2XNNA 2.5 Inactive None None out-none none-out 430 Type1 3 - 271 None None 14
2XNOA 1.98 Inactive None None out-out none-out ED8 Type1 3 - 271 None None 15
5M55A 2.4 Inactive None None out-none none-none 7GG Type1 3 - 271 None None 19
6SGDA 2.0 Inactive None None out-none none-none LD5 Type1 3 - 271 None None 17
6SGHA 3.0 Inactive None None out-none none-none LCW Type1 3 - 271 None None 21
6SGIA 2.3 Inactive None None out-out none-out LCB Type1 3 - 271 None None 16
6SGKA 2.0 Inactive None None out-none none-none LCQ Type1 3 - 271 None None 16
6SK9A 2.0 Inactive None None out-none none-none F9N Type1 4 - 271 None None 17
2JAVA 2.2 Inactive None None out-out none-none 5Z5 Type1 3 - 271 T175A None 11

NEK2 (Serine/threonine-protein kinase Nek2)

Group: NEK
Total number of chains: 30
Spatial Dihedral Chains Representative
DFGin BLAminus 1 AF-P51955-K1A
DFGin BLBminus 1 5M53A
DFGin None 5 5M51A
DFGinter None 2 2W5BA
DFGout None 6 2XNPA
None None 15 2W5AA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens NEK2_HUMAN AF-P51955-K1A -1.0 Active DFGin BLAminus out-in in-in No_ligand No_ligand 1 - 279 None None 0
Homo sapiens NEK2_HUMAN 5M53A 1.9 Inactive DFGin BLBminus out-out none-out 7GJ Type1 7 - 271 None None 14
Homo sapiens NEK2_HUMAN 2XKDA 1.96 Inactive DFGin None out-out none-none T3M Type1 3 - 271 None None 14
Homo sapiens NEK2_HUMAN 2XKEA 2.203 Inactive DFGin None out-out none-none WI2 Type1 3 - 271 None None 18
Homo sapiens NEK2_HUMAN 2XKFA 2.35 Inactive DFGin None out-out none-out BX1 Type1 3 - 271 None None 15
Homo sapiens NEK2_HUMAN 5M51A 1.899 Inactive DFGin None out-none none-out NU6 Type1 3 - 271 None None 16
Homo sapiens NEK2_HUMAN 5M57A 2.3 Inactive DFGin None out-none none-out 4SP Type1 3 - 271 None None 16
Homo sapiens NEK2_HUMAN 2W5HA 2.33 Inactive DFGinter None out-none none-out No_ligand No_ligand 3 - 271 T175A None 3
Homo sapiens NEK2_HUMAN 2W5BA 2.4 Inactive DFGinter None out-out out-out AGS Type1 3 - 271 T175A None 0
Homo sapiens NEK2_HUMAN 2XK3A 2.2 Inactive DFGout None out-out none-out XK3 Type1 3 - 271 None None 15
Homo sapiens NEK2_HUMAN 2XK4A 2.1 Inactive DFGout None out-out none-out OL2 Type1 3 - 271 None None 13
Homo sapiens NEK2_HUMAN 2XK8A 2.001 Inactive DFGout None out-out none-out 5R1 Type1 3 - 271 None None 15
Homo sapiens NEK2_HUMAN 2XNPA 1.98 Inactive DFGout None out-out none-out WCX Type1 3 - 271 None None 13
Homo sapiens NEK2_HUMAN 4AFEA 2.597 Inactive DFGout None out-out none-out GGY Type1 3 - 271 None None 14
Homo sapiens NEK2_HUMAN 4A4XA 2.4 Inactive DFGout None out-out none-out JUP Type1 3 - 271 T170E,S171D,T175E None 14
Homo sapiens NEK2_HUMAN 2W5AA 1.55 Inactive None None out-out out-out ADP Type1 3 - 271 None None 3
Homo sapiens NEK2_HUMAN 2WQOA 2.167 Inactive None None out-out none-none VGK Type1 3 - 271 None None 18
Homo sapiens NEK2_HUMAN 2XK6A 2.2 Inactive None None out-out none-out EQH Type1 4 - 271 None None 17
Homo sapiens NEK2_HUMAN 2XK7A 1.992 Inactive None None out-out none-out 30E Type1 3 - 271 None None 16
Homo sapiens NEK2_HUMAN 2XKCA 2.5 Inactive None None out-none none-none 4VQ Type1 3 - 271 None None 18
Homo sapiens NEK2_HUMAN 2XNMA 1.85 Inactive None None out-out none-out WGZ Type1 3 - 271 None None 9
Homo sapiens NEK2_HUMAN 2XNNA 2.5 Inactive None None out-none none-out 430 Type1 3 - 271 None None 14
Homo sapiens NEK2_HUMAN 2XNOA 1.98 Inactive None None out-out none-out ED8 Type1 3 - 271 None None 15
Homo sapiens NEK2_HUMAN 5M55A 2.4 Inactive None None out-none none-none 7GG Type1 3 - 271 None None 19
Homo sapiens NEK2_HUMAN 6SGDA 2.0 Inactive None None out-none none-none LD5 Type1 3 - 271 None None 17
Homo sapiens NEK2_HUMAN 6SGHA 3.0 Inactive None None out-none none-none LCW Type1 3 - 271 None None 21
Homo sapiens NEK2_HUMAN 6SGIA 2.3 Inactive None None out-out none-out LCB Type1 3 - 271 None None 16
Homo sapiens NEK2_HUMAN 6SGKA 2.0 Inactive None None out-none none-none LCQ Type1 3 - 271 None None 16
Homo sapiens NEK2_HUMAN 6SK9A 2.0 Inactive None None out-none none-none F9N Type1 4 - 271 None None 17
Homo sapiens NEK2_HUMAN 2JAVA 2.2 Inactive None None out-out none-none 5Z5 Type1 3 - 271 T175A None 11

NEK2 (Serine/threonine-protein kinase Nek2)

No non-human structures known.