MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Group: STE
Uniprot: M4K1_HUMAN
Domain boundary: 17 - 274


Total number of chains: 62
Spatial Dihedral Chains Representative
DFGin BLAminus 33 AF-Q92918-K1A
DFGin ABAminus 2 6NFYB
DFGin None 12 7SIUA
DFGout BBAminus 9 7M0KA
DFGout None 2 8CDWA
None None 4 6CQEB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
6NFYA 2.17 Inactive DFGin ABAminus out-out out-in B49 Type1 10 - 292 None None 0
6NFYB 2.17 Inactive DFGin ABAminus out-out out-in B49 Type1 10 - 292 None None 0
AF-Q92918-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 9 - 282 None None 0
7KACB 1.85 Inactive DFGin BLAminus in-out out-out W9D Type1 7 - 294 L221D,F225E None 0
7M0MA 1.93 Inactive DFGin BLAminus in-in out-out YK1 Type1 2 - 294 None None 0
7M0MB 1.93 Inactive DFGin BLAminus in-in out-out YK1 Type1 3 - 293 None None 0
6CQDA 2.12 Inactive DFGin BLAminus in-in out-out ANP Type1 2 - 293 None None 0
6CQDB 2.12 Inactive DFGin BLAminus in-in out-out ANP Type1 4 - 293 None None 0
7R9NA 1.5 Inactive DFGin BLAminus in-in out-out F97 Type1 3 - 293 None None 0
7R9NB 1.5 Inactive DFGin BLAminus in-out out-out F97 Type1 4 - 293 None None 0
7R9PA 2.27 Inactive DFGin BLAminus in-out out-out 2WI Type1 5 - 293 None None 0
7R9PB 2.27 Inactive DFGin BLAminus in-out out-out 2WI Type1 3 - 293 None None 0
7R9TA 2.0 Inactive DFGin BLAminus in-out out-out 2TR Type1 3 - 293 None None 0
7R9TB 2.0 Inactive DFGin BLAminus out-out out-out 2TR Type1 4 - 293 None None 0
6NFZA 2.966 None DFGin BLAminus in-none in-in B49 Type1 7 - 292 None X165,X171 0
6NFZB 2.966 Active DFGin BLAminus in-in in-in B49 Type1 5 - 292 None X165,X171 3
8FH4A 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 4 - 293 T165E,S171E None 0
8FH4B 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 6 - 302 T165E,S171E None 0
8FH4C 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 1 - 292 T165E,S171E None 0
8FH4D 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 8 - 292 T165E,S171E None 4
8FJZA 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 3 - 292 T165E,S171E None 0
8FJZB 1.897 None DFGin BLAminus in-in out-none Y3I Type1 5 - 292 T165E,S171E None 4
8FJZC 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 5 - 292 T165E,S171E None 0
8FJZD 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 5 - 292 T165E,S171E None 5
8FJZE 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 6 - 292 T165E,S171E None 0
8FJZF 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 9 - 292 T165E,S171E None 0
8FKOA 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 4 - 292 T165E,S171E None 0
8FKOB 2.104 None DFGin BLAminus in-in out-none Y3O Type1 5 - 292 T165E,S171E None 7
8FKOC 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 5 - 292 T165E,S171E None 0
8FKOD 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 5 - 292 T165E,S171E None 5
8FKOE 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 9 - 292 T165E,S171E None 0
7L24A 2.68 None DFGin BLAminus in-in out-none XHV Type1 7 - 293 S171A,G191C None 4
7L24B 2.68 Inactive DFGin BLAminus in-in out-out XHV Type1 7 - 293 S171A,G191C None 11
7L24C 2.68 None DFGin BLAminus in-in out-none XHV Type1 8 - 293 S171A,G191C None 3
7L24D 2.68 Inactive DFGin BLAminus in-in out-out XHV Type1 8 - 292 S171A,G191C None 0
7KACA 1.85 Inactive DFGin None out-out none-out W9D Type1 7 - 304 L221D,F225E None 15
6NG0A 2.05 Inactive DFGin None out-out out-out B49 Type1 6 - 302 T165E,S171E None 5
6CQFA 2.246 Inactive DFGin None out-out out-out F97 Type1 6 - 293 None None 6
7R9LA 2.332 Inactive DFGin None out-out out-out 2YE Type1 7 - 293 None None 6
7L26A 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 3
7L26B 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 7
7L26C 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 3
7L26D 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 7
7L25A 1.85 Inactive DFGin None out-out out-out XHS Type1 7 - 294 S171A,G191C None 0
7L25B 1.85 Inactive DFGin None out-out out-out XHS Type1 6 - 293 S171A,G191C None 0
7SIUA 1.786 Inactive DFGin None out-out out-out 9ID Type1.5_Back 5 - 294 None None 0
7SIUB 1.786 Inactive DFGin None out-out out-out 9ID Type1.5_Back 16 - 294 None None 0
7M0KA 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 6 - 294 None None 0
7M0KB 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 8 - 294 None None 0
7M0KC 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 8 - 294 None None 0
7M0KD 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 6 - 294 None None 0
7M0LA 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 6 - 294 None None 0
7M0LB 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 7 - 291 None None 0
7M0LC 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 5 - 293 None None 0
7M0LD 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 6 - 294 None None 0
6NG0B 2.05 Inactive DFGout BBAminus out-out out-out B49 Type1 7 - 293 T165E,S171E None 0
8CDWA 1.941 Inactive DFGout None out-out out-out UES Type1 7 - 294 None None 3
8CIJA 2.821 Inactive DFGout None out-out none-in USF Type1 14 - 294 None None 12
8FKOF 2.104 Inactive None None none-none out-out No_ligand No_ligand 57 - 292 T165E,S171E None 0
6CQEA 1.886 Inactive None None out-out out-out No_ligand No_ligand 4 - 293 S171A None 0
6CQEB 1.886 Inactive None None out-out out-out No_ligand No_ligand 5 - 293 S171A None 0
8CDWB 1.941 Inactive None None out-out none-out UES Type1 9 - 294 None None 9

MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

Group: STE
Total number of chains: 62
Spatial Dihedral Chains Representative
DFGin BLAminus 33 AF-Q92918-K1A
DFGin ABAminus 2 6NFYB
DFGin None 12 7SIUA
DFGout BBAminus 9 7M0KA
DFGout None 2 8CDWA
None None 4 6CQEB
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens M4K1_HUMAN 6NFYA 2.17 Inactive DFGin ABAminus out-out out-in B49 Type1 10 - 292 None None 0
Homo sapiens M4K1_HUMAN 6NFYB 2.17 Inactive DFGin ABAminus out-out out-in B49 Type1 10 - 292 None None 0
Homo sapiens M4K1_HUMAN AF-Q92918-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 9 - 282 None None 0
Homo sapiens M4K1_HUMAN 7KACB 1.85 Inactive DFGin BLAminus in-out out-out W9D Type1 7 - 294 L221D,F225E None 0
Homo sapiens M4K1_HUMAN 7M0MA 1.93 Inactive DFGin BLAminus in-in out-out YK1 Type1 2 - 294 None None 0
Homo sapiens M4K1_HUMAN 7M0MB 1.93 Inactive DFGin BLAminus in-in out-out YK1 Type1 3 - 293 None None 0
Homo sapiens M4K1_HUMAN 6CQDA 2.12 Inactive DFGin BLAminus in-in out-out ANP Type1 2 - 293 None None 0
Homo sapiens M4K1_HUMAN 6CQDB 2.12 Inactive DFGin BLAminus in-in out-out ANP Type1 4 - 293 None None 0
Homo sapiens M4K1_HUMAN 7R9NA 1.5 Inactive DFGin BLAminus in-in out-out F97 Type1 3 - 293 None None 0
Homo sapiens M4K1_HUMAN 7R9NB 1.5 Inactive DFGin BLAminus in-out out-out F97 Type1 4 - 293 None None 0
Homo sapiens M4K1_HUMAN 7R9PA 2.27 Inactive DFGin BLAminus in-out out-out 2WI Type1 5 - 293 None None 0
Homo sapiens M4K1_HUMAN 7R9PB 2.27 Inactive DFGin BLAminus in-out out-out 2WI Type1 3 - 293 None None 0
Homo sapiens M4K1_HUMAN 7R9TA 2.0 Inactive DFGin BLAminus in-out out-out 2TR Type1 3 - 293 None None 0
Homo sapiens M4K1_HUMAN 7R9TB 2.0 Inactive DFGin BLAminus out-out out-out 2TR Type1 4 - 293 None None 0
Homo sapiens M4K1_HUMAN 6NFZA 2.966 None DFGin BLAminus in-none in-in B49 Type1 7 - 292 None X165,X171 0
Homo sapiens M4K1_HUMAN 6NFZB 2.966 Active DFGin BLAminus in-in in-in B49 Type1 5 - 292 None X165,X171 3
Homo sapiens M4K1_HUMAN 8FH4A 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 4 - 293 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FH4B 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 6 - 302 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FH4C 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 1 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FH4D 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1 8 - 292 T165E,S171E None 4
Homo sapiens M4K1_HUMAN 8FJZA 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 3 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FJZB 1.897 None DFGin BLAminus in-in out-none Y3I Type1 5 - 292 T165E,S171E None 4
Homo sapiens M4K1_HUMAN 8FJZC 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 5 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FJZD 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 5 - 292 T165E,S171E None 5
Homo sapiens M4K1_HUMAN 8FJZE 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 6 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FJZF 1.897 Inactive DFGin BLAminus in-in out-out Y3I Type1 9 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FKOA 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 4 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FKOB 2.104 None DFGin BLAminus in-in out-none Y3O Type1 5 - 292 T165E,S171E None 7
Homo sapiens M4K1_HUMAN 8FKOC 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 5 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8FKOD 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 5 - 292 T165E,S171E None 5
Homo sapiens M4K1_HUMAN 8FKOE 2.104 Inactive DFGin BLAminus in-in out-out Y3O Type1 9 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 7L24A 2.68 None DFGin BLAminus in-in out-none XHV Type1 7 - 293 S171A,G191C None 4
Homo sapiens M4K1_HUMAN 7L24B 2.68 Inactive DFGin BLAminus in-in out-out XHV Type1 7 - 293 S171A,G191C None 11
Homo sapiens M4K1_HUMAN 7L24C 2.68 None DFGin BLAminus in-in out-none XHV Type1 8 - 293 S171A,G191C None 3
Homo sapiens M4K1_HUMAN 7L24D 2.68 Inactive DFGin BLAminus in-in out-out XHV Type1 8 - 292 S171A,G191C None 0
Homo sapiens M4K1_HUMAN 7KACA 1.85 Inactive DFGin None out-out none-out W9D Type1 7 - 304 L221D,F225E None 15
Homo sapiens M4K1_HUMAN 6NG0A 2.05 Inactive DFGin None out-out out-out B49 Type1 6 - 302 T165E,S171E None 5
Homo sapiens M4K1_HUMAN 6CQFA 2.246 Inactive DFGin None out-out out-out F97 Type1 6 - 293 None None 6
Homo sapiens M4K1_HUMAN 7R9LA 2.332 Inactive DFGin None out-out out-out 2YE Type1 7 - 293 None None 6
Homo sapiens M4K1_HUMAN 7L26A 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 3
Homo sapiens M4K1_HUMAN 7L26B 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 7
Homo sapiens M4K1_HUMAN 7L26C 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 3
Homo sapiens M4K1_HUMAN 7L26D 2.3 Inactive DFGin None out-out out-out XHM Type1 8 - 294 S171A,G191C None 7
Homo sapiens M4K1_HUMAN 7L25A 1.85 Inactive DFGin None out-out out-out XHS Type1 7 - 294 S171A,G191C None 0
Homo sapiens M4K1_HUMAN 7L25B 1.85 Inactive DFGin None out-out out-out XHS Type1 6 - 293 S171A,G191C None 0
Homo sapiens M4K1_HUMAN 7SIUA 1.786 Inactive DFGin None out-out out-out 9ID Type1.5_Back 5 - 294 None None 0
Homo sapiens M4K1_HUMAN 7SIUB 1.786 Inactive DFGin None out-out out-out 9ID Type1.5_Back 16 - 294 None None 0
Homo sapiens M4K1_HUMAN 7M0KA 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 6 - 294 None None 0
Homo sapiens M4K1_HUMAN 7M0KB 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 8 - 294 None None 0
Homo sapiens M4K1_HUMAN 7M0KC 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 8 - 294 None None 0
Homo sapiens M4K1_HUMAN 7M0KD 2.01 Inactive DFGout BBAminus out-out out-out YK7 Type1 6 - 294 None None 0
Homo sapiens M4K1_HUMAN 7M0LA 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 6 - 294 None None 0
Homo sapiens M4K1_HUMAN 7M0LB 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 7 - 291 None None 0
Homo sapiens M4K1_HUMAN 7M0LC 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 5 - 293 None None 0
Homo sapiens M4K1_HUMAN 7M0LD 2.43 Inactive DFGout BBAminus out-out out-out YK4 Type1 6 - 294 None None 0
Homo sapiens M4K1_HUMAN 6NG0B 2.05 Inactive DFGout BBAminus out-out out-out B49 Type1 7 - 293 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 8CDWA 1.941 Inactive DFGout None out-out out-out UES Type1 7 - 294 None None 3
Homo sapiens M4K1_HUMAN 8CIJA 2.821 Inactive DFGout None out-out none-in USF Type1 14 - 294 None None 12
Homo sapiens M4K1_HUMAN 8FKOF 2.104 Inactive None None none-none out-out No_ligand No_ligand 57 - 292 T165E,S171E None 0
Homo sapiens M4K1_HUMAN 6CQEA 1.886 Inactive None None out-out out-out No_ligand No_ligand 4 - 293 S171A None 0
Homo sapiens M4K1_HUMAN 6CQEB 1.886 Inactive None None out-out out-out No_ligand No_ligand 5 - 293 S171A None 0
Homo sapiens M4K1_HUMAN 8CDWB 1.941 Inactive None None out-out none-out UES Type1 9 - 294 None None 9

MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)

No non-human structures known.