8FKO

MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)
Group: STE
Uniprot: M4K1_HUMAN
Organism: Homo sapiens
Domain boundary: 17 - 274
Resolu: 2.104

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-in out-out Y3O Type1 4 - 292 0
B None DFGin BLAminus in-in out-none Y3O Type1 5 - 292 7
C Inactive DFGin BLAminus in-in out-out Y3O Type1 5 - 292 0
D Inactive DFGin BLAminus in-in out-out Y3O Type1 5 - 292 5
E Inactive DFGin BLAminus in-in out-out Y3O Type1 9 - 292 0
F Inactive None None none-none out-out No_ligand No_ligand 57 - 292 0
Representative sequence - Chain F
- - 6 16
mashhhhhhd ydgattenly fqgsmdvvdp difnrdprdh
26 36 46 56
ydllqrlggg tygevfkard kvsgdlvalk mvkmepdddv
66 76 86 96
STLQKEILIL KTCRHANIVA YHGsylwlqk lwiCMEFCGA
106 116 126 136
GSLQDIYQVT GSLSELQISY VCREVLQGLA YLHSQKKIHR
146 156 166 176
DIKGANILIN DAGEVRLADF GISAQIGAEL ARRLEFIGTP
186 196 206 216
YWMAPEVAAV ALKGGYNELC DIWSLGITAI ELAELQPPLF
226 236 246 256
DVHPLRVLFL MTKSGYQPPR LKEkgKWSAA FHNFIKVTLT
266 276 286 296
KSPKKRPSAT KMLSHQLVSQ PGLNRGLILD LLDKLKnpgk
306
gpsigdiede e
Lower-case residues are disordered in structure.
Mutations: T165E,S171E
Phosphorylation: None