7L25

MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)
Group: STE
Uniprot: M4K1_HUMAN
Organism: Homo sapiens
Domain boundary: 17 - 274
Resolu: 1.85

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None out-out out-out XHS Type1 7 - 294 0
B Inactive DFGin None out-out out-out XHS Type1 6 - 293 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
        15         25         35         45 
PDIFNRDPRD HYDLLQRLGG GTYGEVFKAR DKVSGDLVAL 
        55         65         75         85 
KMVKMEPDDD VSTLQKEILI LKTCRHANIV AYHGSYLWLQ 
        95        105        115        125 
KLWICMEFCG AGSLQDIYQV TGSLSELQIS YVCREVLQGL 
       135        145        155        165 
AYLHSQKKIH RDIKGANILI NDAGEVRLAD FGISAQIGAT 
       175        185        195        205 
LARRLAFIGT PYWMAPEVAA VALKGCYNEL CDIWSLGITA 
       215        225        235        245 
IELAELQPPL FDVHPLRVLF LMTKSGYQPP RLKEKGKWSA 
       255        265        275        285 
AFHNFIKVTL TKSPKKRPSA TKMLSHQLVS QPGLNRGLIL 

DLLDKLKNp
Lower-case residues are disordered in structure.
Mutations: S171A,G191C
Phosphorylation: None