GRK2 (Beta-adrenergic receptor kinase 1)

Group: AGC
Uniprot: ARBK1_HUMAN
Domain boundary: 191 - 453


Total number of chains: 20
Spatial Dihedral Chains Representative
DFGin BLAminus 16 AF-P25098-K1A
DFGin None 4 7PWDA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P25098-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 183 - 461 None None 0
5UVCA 2.65 Active DFGin BLAminus in-in in-in 8PV Type1 30 - 536 None None 0
5UKLA 2.15 Active DFGin BLAminus in-in in-in SIX Type1 31 - 671 S670A None 0
5HE1A 3.15 Active DFGin BLAminus in-in in-in ZS2 Type1 29 - 668 S670A None 0
6C2YA 2.74 Active DFGin BLAminus in-in in-in EJS Type1 30 - 668 S670A None 0
4MK0A 2.4 Active DFGin BLAminus in-in in-in 29X Type1 30 - 668 None None 0
7K7LA 2.539 Active DFGin BLAminus in-in in-in W4D Type1 30 - 668 None None 0
7K7ZA 2.606 Active DFGin BLAminus in-in in-in W4G Type1 30 - 668 None None 0
3V5WA 2.07 Active DFGin BLAminus in-in in-in 8PR Type1 30 - 668 None None 0
4PNKA 2.56 Active DFGin BLAminus in-in in-in KZQ Type1 30 - 668 None None 0
5WG3A 2.896 Active DFGin BLAminus in-in in-in AFM Type1 30 - 668 None None 0
5WG4A 2.31 Active DFGin BLAminus in-in in-in AFV Type1 31 - 668 None None 0
5WG5A 3.1 Active DFGin BLAminus in-in in-in ZSO Type1 30 - 668 None None 0
5UUUA 2.7 Active DFGin BLAminus in-in in-in QRW Type1.5_Front 31 - 538 None None 0
5UKKA 2.6 Active DFGin BLAminus in-in in-in 8DJ Type1.5_Front 30 - 667 S670A None 0
6U7CA 2.44 Active DFGin BLAminus in-in in-in Q1Y Type1.5_Front 30 - 669 None None 0
3CIKA 2.75 Inactive DFGin None in-in in-in No_ligand No_ligand 29 - 669 None None 0
7PWDA 2.6 Inactive DFGin None in-in in-in 8DS Type1 27 - 668 S670A None 0
3KRWA 2.9 Inactive DFGin None in-in in-in BA1 Type1 30 - 671 None None 0
3KRXA 3.1 Inactive DFGin None in-in in-in BA1 Type1 30 - 671 None None 0

GRK2 (Beta-adrenergic receptor kinase 1)

Group: AGC
Total number of chains: 38
Spatial Dihedral Chains Representative
DFGin BLAminus 20 AF-P25098-K1A
DFGin ABAminus 4 8JPDG
DFGin None 14 3PVUA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Bos taurus ARBK1_BOVIN 1YM7B 4.5 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 8JPBG 3.07 Inactive DFGin ABAminus in-out in-in STU Type1 2 - 659 A292P,R295I,S455D None 0
Bos taurus ARBK1_BOVIN 8JPCG 3.07 Inactive DFGin ABAminus in-out in-in STU Type1 2 - 659 A292P,R295I,S455D None 0
Bos taurus ARBK1_BOVIN 8JPDG 2.81 Inactive DFGin ABAminus in-out in-in STU Type1 2 - 659 A292P,R295I,S455D None 0
Bos taurus ARBK1_BOVIN 5HE0A 2.56 Active DFGin BLAminus in-in in-in 453 Type1 30 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 5HE2A 2.79 Active DFGin BLAminus in-in in-in F0S Type1 30 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 5HE3A 2.74 Active DFGin BLAminus in-in in-in FF1 Type1 30 - 670 None None 0
Bos taurus ARBK1_BOVIN 5UKMA 3.03 Active DFGin BLAminus in-in in-in T0E Type1 31 - 669 S670A None 0
Bos taurus ARBK1_BOVIN 1OMWA 2.5 Inactive DFGin None in-in in-in No_ligand No_ligand 29 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 1YM7A 4.5 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 1YM7C 4.5 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 1YM7D 4.5 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 2BCJA 3.061 Inactive DFGin None in-in in-in No_ligand No_ligand 28 - 667 S670A None 0
Bos taurus ARBK1_BOVIN 3UZSA 4.52 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 671 S670A None 0
Bos taurus ARBK1_BOVIN 3UZTA 3.51 Inactive DFGin None in-out in-in No_ligand No_ligand 30 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 3PSCA 2.67 Inactive DFGin None in-in in-in No_ligand No_ligand 29 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 3PVUA 2.48 Inactive DFGin None in-in in-in QRW Type1 30 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 3PVWA 2.49 Inactive DFGin None in-in in-in QRX Type1 29 - 668 S670A None 0
Homo sapiens ARBK1_HUMAN AF-P25098-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 183 - 461 None None 0
Homo sapiens ARBK1_HUMAN 5UVCA 2.65 Active DFGin BLAminus in-in in-in 8PV Type1 30 - 536 None None 0
Homo sapiens ARBK1_HUMAN 5UKLA 2.15 Active DFGin BLAminus in-in in-in SIX Type1 31 - 671 S670A None 0
Homo sapiens ARBK1_HUMAN 5HE1A 3.15 Active DFGin BLAminus in-in in-in ZS2 Type1 29 - 668 S670A None 0
Homo sapiens ARBK1_HUMAN 6C2YA 2.74 Active DFGin BLAminus in-in in-in EJS Type1 30 - 668 S670A None 0
Homo sapiens ARBK1_HUMAN 4MK0A 2.4 Active DFGin BLAminus in-in in-in 29X Type1 30 - 668 None None 0
Homo sapiens ARBK1_HUMAN 7K7LA 2.539 Active DFGin BLAminus in-in in-in W4D Type1 30 - 668 None None 0
Homo sapiens ARBK1_HUMAN 7K7ZA 2.606 Active DFGin BLAminus in-in in-in W4G Type1 30 - 668 None None 0
Homo sapiens ARBK1_HUMAN 3V5WA 2.07 Active DFGin BLAminus in-in in-in 8PR Type1 30 - 668 None None 0
Homo sapiens ARBK1_HUMAN 4PNKA 2.56 Active DFGin BLAminus in-in in-in KZQ Type1 30 - 668 None None 0
Homo sapiens ARBK1_HUMAN 5WG3A 2.896 Active DFGin BLAminus in-in in-in AFM Type1 30 - 668 None None 0
Homo sapiens ARBK1_HUMAN 5WG4A 2.31 Active DFGin BLAminus in-in in-in AFV Type1 31 - 668 None None 0
Homo sapiens ARBK1_HUMAN 5WG5A 3.1 Active DFGin BLAminus in-in in-in ZSO Type1 30 - 668 None None 0
Homo sapiens ARBK1_HUMAN 5UUUA 2.7 Active DFGin BLAminus in-in in-in QRW Type1.5_Front 31 - 538 None None 0
Homo sapiens ARBK1_HUMAN 5UKKA 2.6 Active DFGin BLAminus in-in in-in 8DJ Type1.5_Front 30 - 667 S670A None 0
Homo sapiens ARBK1_HUMAN 6U7CA 2.44 Active DFGin BLAminus in-in in-in Q1Y Type1.5_Front 30 - 669 None None 0
Homo sapiens ARBK1_HUMAN 3CIKA 2.75 Inactive DFGin None in-in in-in No_ligand No_ligand 29 - 669 None None 0
Homo sapiens ARBK1_HUMAN 7PWDA 2.6 Inactive DFGin None in-in in-in 8DS Type1 27 - 668 S670A None 0
Homo sapiens ARBK1_HUMAN 3KRWA 2.9 Inactive DFGin None in-in in-in BA1 Type1 30 - 671 None None 0
Homo sapiens ARBK1_HUMAN 3KRXA 3.1 Inactive DFGin None in-in in-in BA1 Type1 30 - 671 None None 0

GRK2 (Beta-adrenergic receptor kinase 1)

Group: AGC
Total number of chains: 18
Spatial Dihedral Chains Representative
DFGin BLAminus 4 5HE0A
DFGin ABAminus 4 8JPDG
DFGin None 10 3PVUA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Bos taurus ARBK1_BOVIN 1YM7B 4.5 Inactive DFGin ABAminus in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 8JPBG 3.07 Inactive DFGin ABAminus in-out in-in STU Type1 2 - 659 A292P,R295I,S455D None 0
Bos taurus ARBK1_BOVIN 8JPCG 3.07 Inactive DFGin ABAminus in-out in-in STU Type1 2 - 659 A292P,R295I,S455D None 0
Bos taurus ARBK1_BOVIN 8JPDG 2.81 Inactive DFGin ABAminus in-out in-in STU Type1 2 - 659 A292P,R295I,S455D None 0
Bos taurus ARBK1_BOVIN 5HE0A 2.56 Active DFGin BLAminus in-in in-in 453 Type1 30 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 5HE2A 2.79 Active DFGin BLAminus in-in in-in F0S Type1 30 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 5HE3A 2.74 Active DFGin BLAminus in-in in-in FF1 Type1 30 - 670 None None 0
Bos taurus ARBK1_BOVIN 5UKMA 3.03 Active DFGin BLAminus in-in in-in T0E Type1 31 - 669 S670A None 0
Bos taurus ARBK1_BOVIN 1OMWA 2.5 Inactive DFGin None in-in in-in No_ligand No_ligand 29 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 1YM7A 4.5 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 1YM7C 4.5 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 1YM7D 4.5 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 2BCJA 3.061 Inactive DFGin None in-in in-in No_ligand No_ligand 28 - 667 S670A None 0
Bos taurus ARBK1_BOVIN 3UZSA 4.52 Inactive DFGin None in-out in-in No_ligand No_ligand 29 - 671 S670A None 0
Bos taurus ARBK1_BOVIN 3UZTA 3.51 Inactive DFGin None in-out in-in No_ligand No_ligand 30 - 656 S670A None 0
Bos taurus ARBK1_BOVIN 3PSCA 2.67 Inactive DFGin None in-in in-in No_ligand No_ligand 29 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 3PVUA 2.48 Inactive DFGin None in-in in-in QRW Type1 30 - 668 S670A None 0
Bos taurus ARBK1_BOVIN 3PVWA 2.49 Inactive DFGin None in-in in-in QRX Type1 29 - 668 S670A None 0