EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Group: OTHER

Uniprot: E2AK2_HUMAN

Domain boundary: 267 - 538

Total number of chains: 11

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	AF-P19525-K1A
DFGin	ABAminus	4	8QELB
DFGin	None	3	3UIUA

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
2A1AB	2.8	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	258 - 541	H412N,C551A	X446	0
8QELB	2.451	Inactive	DFGin	ABAminus	in-in	in-out	UH3	Type1	258 - 541	None	X446	0
2A19B	2.5	Inactive	DFGin	ABAminus	in-in	in-out	ANP	Type1	258 - 541	H412N,C551A	X446	0
2A19C	2.5	Inactive	DFGin	ABAminus	in-in	none-none	ANP	Type1	258 - 541	H412N,C551A	X446	22
AF-P19525-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	259 - 546	None	None	0
6D3KA	2.6	None	DFGin	BLAminus	in-in	in-none	ADP	Type1	256 - 544	None	None	10
6D3KB	2.6	None	DFGin	BLAminus	in-in	in-none	ADP	Type1	255 - 541	None	None	11
6D3KC	2.6	Inactive	DFGin	BLAminus	in-in	in-out	ADP	Type1	257 - 541	None	None	3
6D3LA	3.1	Inactive	DFGin	None	in-out	in-none	No_ligand	No_ligand	258 - 541	None	None	17
3UIUA	2.903	Inactive	DFGin	None	in-none	in-none	No_ligand	No_ligand	254 - 541	None	None	11
3UIUB	2.903	Inactive	DFGin	None	in-none	in-none	No_ligand	No_ligand	254 - 541	None	None	11

EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

Group: OTHER

Total number of chains: 11

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	AF-P19525-K1A
DFGin	ABAminus	4	8QELB
DFGin	None	3	3UIUA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Homo sapiens	E2AK2_HUMAN	2A1AB	2.8	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	258 - 541	H412N,C551A	X446	0
Homo sapiens	E2AK2_HUMAN	8QELB	2.451	Inactive	DFGin	ABAminus	in-in	in-out	UH3	Type1	258 - 541	None	X446	0
Homo sapiens	E2AK2_HUMAN	2A19B	2.5	Inactive	DFGin	ABAminus	in-in	in-out	ANP	Type1	258 - 541	H412N,C551A	X446	0
Homo sapiens	E2AK2_HUMAN	2A19C	2.5	Inactive	DFGin	ABAminus	in-in	none-none	ANP	Type1	258 - 541	H412N,C551A	X446	22
Homo sapiens	E2AK2_HUMAN	AF-P19525-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	259 - 546	None	None	0
Homo sapiens	E2AK2_HUMAN	6D3KA	2.6	None	DFGin	BLAminus	in-in	in-none	ADP	Type1	256 - 544	None	None	10
Homo sapiens	E2AK2_HUMAN	6D3KB	2.6	None	DFGin	BLAminus	in-in	in-none	ADP	Type1	255 - 541	None	None	11
Homo sapiens	E2AK2_HUMAN	6D3KC	2.6	Inactive	DFGin	BLAminus	in-in	in-out	ADP	Type1	257 - 541	None	None	3
Homo sapiens	E2AK2_HUMAN	6D3LA	3.1	Inactive	DFGin	None	in-out	in-none	No_ligand	No_ligand	258 - 541	None	None	17
Homo sapiens	E2AK2_HUMAN	3UIUA	2.903	Inactive	DFGin	None	in-none	in-none	No_ligand	No_ligand	254 - 541	None	None	11
Homo sapiens	E2AK2_HUMAN	3UIUB	2.903	Inactive	DFGin	None	in-none	in-none	No_ligand	No_ligand	254 - 541	None	None	11

EIF2AK2 (Interferon-induced, double-stranded RNA-activated protein kinase)

No non-human structures known.