PDB: 4H58 — TKL BRAF_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 4H58B
DFGin None 1 33.3% 4H58A
DFGout BBAminus 1 33.3% 4H58C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 4H58B P15056 448 722 766.0 No_ligand No_ligand Inactive DFGin 6.8397 14.8241 ABAminus -98.82, -88.13 -93.34, 121.12 -119.32, 28.65 302.28, 124.2 -55.88, -57.22 in-in in 8.2695 Saltbr-in 3.3923 HRD-in -67.57, -56.11 87.58, -17.44 in-in-out SNCiio in-out ActLoopNT-in 3.0197 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 58.08, 30.11 APE9-dihe-na 109.46, 38.41 APE8-dihe-out -130.74, 22.57 APE8-rot-in 295.42 APE67-dihe-in -65.56, -25.13 -73.36, -24.11 APE12-dist-none 999.0 APE11-dist-out 14.0431 APE10-dist-out 13.4628 APE9-dist-out 11.1085 None None None XRAY 3.1 0.224 0.272 B 275.0 262.0 13 30 17 13 [[457, 716]] 1.0 4h58 TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4H58A P15056 448 722 766.0 10Z:60801 Type1 Inactive DFGin 5.9602 13.7224 None -110.59, -118.32 -39.31, 108.26 -95.89, 11.56 277.46, 88.25 -35.77, -74.73 in-in in 8.3024 Saltbr-in 2.7643 HRD-in -69.13, -43.65 65.49, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8347 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 79.67 APE9-dihe-na -70.74, 22.44 APE8-dihe-in -101.01, 94.21 APE8-rot-in 260.42 APE67-dihe-in -50.49, -22.55 -89.83, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.5653 APE9-dist-out 10.3075 None None None XRAY 3.1 0.224 0.272 A 275.0 263.0 12 30 18 12 [[457, 716]] 1.0 4h58 TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4H58C P15056 449 722 766.0 No_ligand No_ligand Inactive DFGout 12.3142 12.2286 BBAminus -160.6, -162.0 -123.7, 93.43 -89.2, -0.33 292.68, 81.74 36.99, -133.77 in-in in 7.705 Saltbr-in 2.6471 HRD-in -62.88, -49.99 78.35, 6.93 in-out-out SNCioo out-out ActLoopNT-out 18.5049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -120.11, -16.47 APE9-dihe-na -80.65, -129.6 APE8-dihe-in -116.99, 109.87 APE8-rot-in 290.33 APE67-dihe-in -66.58, -13.25 -83.92, -32.56 APE12-dist-out 20.8269 APE11-dist-out 17.5816 APE10-dist-out 13.4093 APE9-dist-out 9.2583 None None None XRAY 3.1 0.224 0.272 C 275.0 272.0 2 30 30 0 [[457, 716]] 1.0 4h58 TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

PDB: 4H58 — TKL BRAF_HUMAN

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 33.3% 4H58B
DFGin None 1 33.3% 4H58A
DFGout BBAminus 1 33.3% 4H58C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRAF BRAF_HUMAN 4H58B P15056 448 722 766.0 No_ligand No_ligand Inactive DFGin 6.8397 14.8241 ABAminus -98.82, -88.13 -93.34, 121.12 -119.32, 28.65 302.28, 124.2 -55.88, -57.22 in-in in 8.2695 Saltbr-in 3.3923 HRD-in -67.57, -56.11 87.58, -17.44 in-in-out SNCiio in-out ActLoopNT-in 3.0197 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na 58.08, 30.11 APE9-dihe-na 109.46, 38.41 APE8-dihe-out -130.74, 22.57 APE8-rot-in 295.42 APE67-dihe-in -65.56, -25.13 -73.36, -24.11 APE12-dist-none 999.0 APE11-dist-out 14.0431 APE10-dist-out 13.4628 APE9-dist-out 11.1085 None None None XRAY 3.1 0.224 0.272 B 275.0 262.0 13 30 17 13 [[457, 716]] 1.0 4h58 Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4H58A P15056 448 722 766.0 10Z:60801 Type1 Inactive DFGin 5.9602 13.7224 None -110.59, -118.32 -39.31, 108.26 -95.89, 11.56 277.46, 88.25 -35.77, -74.73 in-in in 8.3024 Saltbr-in 2.7643 HRD-in -69.13, -43.65 65.49, 6.98 in-in-out SNCiio in-out ActLoopNT-in 2.8347 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnio APE10-dihe-na 999.0, 79.67 APE9-dihe-na -70.74, 22.44 APE8-dihe-in -101.01, 94.21 APE8-rot-in 260.42 APE67-dihe-in -50.49, -22.55 -89.83, -41.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.5653 APE9-dist-out 10.3075 None None None XRAY 3.1 0.224 0.272 A 275.0 263.0 12 30 18 12 [[457, 716]] 1.0 4h58 Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4H58C P15056 449 722 766.0 No_ligand No_ligand Inactive DFGout 12.3142 12.2286 BBAminus -160.6, -162.0 -123.7, 93.43 -89.2, -0.33 292.68, 81.74 36.99, -133.77 in-in in 7.705 Saltbr-in 2.6471 HRD-in -62.88, -49.99 78.35, 6.93 in-out-out SNCioo out-out ActLoopNT-out 18.5049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -120.11, -16.47 APE9-dihe-na -80.65, -129.6 APE8-dihe-in -116.99, 109.87 APE8-rot-in 290.33 APE67-dihe-in -66.58, -13.25 -83.92, -32.56 APE12-dist-out 20.8269 APE11-dist-out 17.5816 APE10-dist-out 13.4093 APE9-dist-out 9.2583 None None None XRAY 3.1 0.224 0.272 C 275.0 272.0 2 30 30 0 [[457, 716]] 1.0 4h58 Homo sapiens TKL_BRAF_HUMAN TKL 7.3e-82 280.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf

PDB: 4H58 — TKL BRAF_HUMAN

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name