Ligand: SGV

Total number of chains: 7
Active chains: 4
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% 4TNBA
DFGin ABAminus 1 14.3% 9CKOA
DFGin None 1 14.3% 6PJXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC GRK5 GRK5_HUMAN 9CKOA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None None G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 4TNBA 2.113 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 15 - 543 0 None None G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKPA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9MX2A 3.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 6PJXA 1.96 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None E104K,R304H,G438E G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 3NYNA 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 2 - 557 0 None None G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 3NYNB 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 2 - 557 0 None None G protein-coupled receptor kinase 6

Ligand: SGV

Total number of chains: 11
Active chains: 5
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 9 81.8% 4TNBA
DFGin ABAminus 1 9.1% 9CKOA
DFGin None 1 9.1% 6PJXA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC GRK1 GRK1_BOVIN 7MT9G 7.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iiio SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 7MT8G 5.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None S5E,S488E,T489E Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 7MTAG 4.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None S5E,S488E,T489E Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 7MTBG 4.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None S5E,S488E,T489E Rhodopsin kinase GRK1 Bos taurus
AGC GRK5 GRK5_HUMAN 9CKOA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None None G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 4TNBA 2.113 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 15 - 543 0 None None G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 9CKPA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 9MX2A 3.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 6PJXA 1.96 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 1 - 542 0 None E104K,R304H,G438E G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK6 GRK6_HUMAN 3NYNA 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 2 - 557 0 None None G protein-coupled receptor kinase 6 Homo sapiens
AGC GRK6 GRK6_HUMAN 3NYNB 2.72 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV Type1 2 - 557 0 None None G protein-coupled receptor kinase 6 Homo sapiens

Ligand: SGV

Total number of chains: 4
Active chains: 1
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 100.0% 7MTBG
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC GRK1 GRK1_BOVIN 7MT9G 7.0 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iiio SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None None Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 7MT8G 5.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None S5E,S488E,T489E Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 7MTAG 4.1 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None S5E,S488E,T489E Rhodopsin kinase GRK1 Bos taurus
AGC GRK1 GRK1_BOVIN 7MTBG 4.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii SGV, SGV, SGV, SGV, SGV, SGV Type1, Type1, Type1, Type1, Type1, Type1 6 - 508 0 None S5E,S488E,T489E Rhodopsin kinase GRK1 Bos taurus