Ligand: MM8

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 6T6DB
DFGin BLAminus 1 25.0% 6T6DD
DFGin None 1 25.0% 6T6DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL ACVR1 ACVR1_HUMAN 6T6DB Q04771 203 499 509.0 MM8:501 Type1 Inactive DFGin 8.0254 13.4567 ABAminus -113.12, -72.46 -79.26, 114.59 -109.76, 17.95 287.15, 78.17 -59.58, -33.57 in-out in 8.2224 Saltbr-out 4.0229 HRD-in -73.05, -64.25 87.23, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.9735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.53, 156.31 APE9-dihe-na -60.36, 167.63 APE8-dihe-in -59.61, 127.94 APE8-rot-in 305.34 APE67-dihe-in -62.73, -26.34 -66.57, -31.38 APE12-dist-in 10.8218 APE11-dist-out 6.6985 APE10-dist-out 8.8674 APE9-dist-in 3.8838 Q207D None None XRAY 2.56 0.224 0.272 B 301.0 297.0 0 32 32 0 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DC Q04771 205 498 509.0 MM8:501 Type1 Inactive DFGin 7.8708 12.5933 ABAminus -116.62, -62.87 -95.88, 111.8 -114.2, 22.29 305.51, 0.83 -66.78, -30.11 in-out in 8.0654 Saltbr-out 3.8085 HRD-in -69.93, -68.13 91.02, -5.92 out-in-in SNCoii in-in ActLoopNT-in 2.8283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.68, 140.63 APE9-dihe-na 133.68, 172.6 APE8-dihe-in -72.52, 124.22 APE8-rot-in 299.66 APE67-dihe-in -70.69, -22.05 -69.0, -25.51 APE12-dist-in 11.262 APE11-dist-in 12.3598 APE10-dist-in 6.6305 APE9-dist-in 4.2181 Q207D None None XRAY 2.56 0.224 0.272 C 301.0 278.0 16 32 21 11 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DD Q04771 203 498 509.0 MM8:501 Type1 Inactive DFGin 7.6173 12.5987 BLAminus -126.5, 165.83 73.29, 84.55 -98.79, 17.26 305.85, 171.23 -61.04, -35.17 in-out in 8.1392 Saltbr-out 5.2205 HRD-in -66.75, -60.44 83.42, 7.04 out-in-none SNCoin in-none ActLoopNT-in 2.7289 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -100.75, 149.74 APE9-dihe-na 135.34, 156.1 APE8-dihe-in -58.61, 125.21 APE8-rot-in 305.55 APE67-dihe-in -57.51, -24.77 -65.16, -37.29 APE12-dist-none 999.0 APE11-dist-in 10.2677 APE10-dist-in 6.7967 APE9-dist-in 4.1818 Q207D None None XRAY 2.56 0.224 0.272 D 301.0 285.0 11 32 21 11 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DA Q04771 204 499 509.0 MM8:501 Type1 Inactive DFGin 8.3091 13.2837 None -109.51, -81.12 -73.5, 111.71 -110.98, 17.65 271.3, 88.6 -66.37, -17.62 in-in in 8.1368 Saltbr-in 3.4958 HRD-in -71.72, -59.58 84.73, 1.24 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.15, 12.06 APE9-dihe-na -92.9, 178.87 APE8-dihe-in -69.31, 121.79 APE8-rot-in 306.54 APE67-dihe-in -58.18, -27.15 -60.78, -34.02 APE12-dist-in 12.1633 APE11-dist-in 11.7611 APE10-dist-in 6.6141 APE9-dist-in 3.7745 Q207D None None XRAY 2.56 0.224 0.272 A 301.0 292.0 4 32 28 4 [[207, 497]] 1.0 6t6d TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: MM8

Total number of chains: 4
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 6T6DB
DFGin BLAminus 1 25.0% 6T6DD
DFGin None 1 25.0% 6T6DA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL ACVR1 ACVR1_HUMAN 6T6DB Q04771 203 499 509.0 MM8:501 Type1 Inactive DFGin 8.0254 13.4567 ABAminus -113.12, -72.46 -79.26, 114.59 -109.76, 17.95 287.15, 78.17 -59.58, -33.57 in-out in 8.2224 Saltbr-out 4.0229 HRD-in -73.05, -64.25 87.23, -2.54 out-in-out SNCoio in-out ActLoopNT-in 2.9735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -123.53, 156.31 APE9-dihe-na -60.36, 167.63 APE8-dihe-in -59.61, 127.94 APE8-rot-in 305.34 APE67-dihe-in -62.73, -26.34 -66.57, -31.38 APE12-dist-in 10.8218 APE11-dist-out 6.6985 APE10-dist-out 8.8674 APE9-dist-in 3.8838 Q207D None None XRAY 2.56 0.224 0.272 B 301.0 297.0 0 32 32 0 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DC Q04771 205 498 509.0 MM8:501 Type1 Inactive DFGin 7.8708 12.5933 ABAminus -116.62, -62.87 -95.88, 111.8 -114.2, 22.29 305.51, 0.83 -66.78, -30.11 in-out in 8.0654 Saltbr-out 3.8085 HRD-in -69.93, -68.13 91.02, -5.92 out-in-in SNCoii in-in ActLoopNT-in 2.8283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.68, 140.63 APE9-dihe-na 133.68, 172.6 APE8-dihe-in -72.52, 124.22 APE8-rot-in 299.66 APE67-dihe-in -70.69, -22.05 -69.0, -25.51 APE12-dist-in 11.262 APE11-dist-in 12.3598 APE10-dist-in 6.6305 APE9-dist-in 4.2181 Q207D None None XRAY 2.56 0.224 0.272 C 301.0 278.0 16 32 21 11 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DD Q04771 203 498 509.0 MM8:501 Type1 Inactive DFGin 7.6173 12.5987 BLAminus -126.5, 165.83 73.29, 84.55 -98.79, 17.26 305.85, 171.23 -61.04, -35.17 in-out in 8.1392 Saltbr-out 5.2205 HRD-in -66.75, -60.44 83.42, 7.04 out-in-none SNCoin in-none ActLoopNT-in 2.7289 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -100.75, 149.74 APE9-dihe-na 135.34, 156.1 APE8-dihe-in -58.61, 125.21 APE8-rot-in 305.55 APE67-dihe-in -57.51, -24.77 -65.16, -37.29 APE12-dist-none 999.0 APE11-dist-in 10.2677 APE10-dist-in 6.7967 APE9-dist-in 4.1818 Q207D None None XRAY 2.56 0.224 0.272 D 301.0 285.0 11 32 21 11 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6T6DA Q04771 204 499 509.0 MM8:501 Type1 Inactive DFGin 8.3091 13.2837 None -109.51, -81.12 -73.5, 111.71 -110.98, 17.65 271.3, 88.6 -66.37, -17.62 in-in in 8.1368 Saltbr-in 3.4958 HRD-in -71.72, -59.58 84.73, 1.24 in-in-in SNCiii in-in ActLoopNT-in 2.8829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.15, 12.06 APE9-dihe-na -92.9, 178.87 APE8-dihe-in -69.31, 121.79 APE8-rot-in 306.54 APE67-dihe-in -58.18, -27.15 -60.78, -34.02 APE12-dist-in 12.1633 APE11-dist-in 11.7611 APE10-dist-in 6.6141 APE9-dist-in 3.7745 Q207D None None XRAY 2.56 0.224 0.272 A 301.0 292.0 4 32 28 4 [[207, 497]] 1.0 6t6d Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1

Ligand: MM8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name