Ligand: LHL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 3KMMA
DFGin BLAplus 1 50.0% 3PJ1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 3PJ1A Q06187 391 659 659.0 LHL:1,LHL:2 Type1,Allosteric Inactive DFGin 4.6315 13.9108 BLAplus -125.24, -177.97 47.53, 37.44 -91.22, -16.21 57.77, 94.29 -84.9, -7.73 in-in in 8.2391 Saltbr-in 3.0498 HRD-in -71.17, -51.36 76.56, -15.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.95 APE8-dihe-in -68.38, 60.28 APE8-rot-na 27.48 APE67-dihe-in -69.28, -12.51 -52.55, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1998 None None None XRAY 2.0 0.223 0.257 A 274.0 241.0 28 29 13 16 [[402, 653]] 1.0 3pj1 TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR LCK LCK_HUMAN 3KMMA P06239 231 501 509.0 LHL:1 Type1.5_Back Active DFGin 6.8628 14.8299 BLAminus -127.6, -179.98 60.86, 89.79 -112.67, 27.22 299.87, 93.25 -61.87, -31.32 in-in in 8.6985 Saltbr-in 3.0559 HRD-in -91.14, -53.45 82.64, -3.08 in-in-in SNCiii in-in ActLoopNT-in 2.8642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.65, 152.15 APE9-dihe-in -136.18, 157.7 APE8-dihe-in -58.05, 115.06 APE8-rot-na 339.75 APE67-dihe-in -80.51, -24.68 -64.53, -28.52 APE12-dist-na 14.1508 APE11-dist-na 9.7097 APE10-dist-na 12.3903 APE9-dist-in 6.6287 Y505F PTR394 PTR394 XRAY 2.8 0.167 0.223 A 288.0 271.0 0 29 29 0 [[245, 496]] 1.0 3kmm TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck

Ligand: LHL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 3KMMA
DFGin BLAplus 1 50.0% 3PJ1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR BTK BTK_HUMAN 3PJ1A Q06187 391 659 659.0 LHL:1,LHL:2 Type1,Allosteric Inactive DFGin 4.6315 13.9108 BLAplus -125.24, -177.97 47.53, 37.44 -91.22, -16.21 57.77, 94.29 -84.9, -7.73 in-in in 8.2391 Saltbr-in 3.0498 HRD-in -71.17, -51.36 76.56, -15.56 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.95 APE8-dihe-in -68.38, 60.28 APE8-rot-na 27.48 APE67-dihe-in -69.28, -12.51 -52.55, -45.17 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1998 None None None XRAY 2.0 0.223 0.257 A 274.0 241.0 28 29 13 16 [[402, 653]] 1.0 3pj1 Homo sapiens TYR_BTK_HUMAN TYR 6.3e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR LCK LCK_HUMAN 3KMMA P06239 231 501 509.0 LHL:1 Type1.5_Back Active DFGin 6.8628 14.8299 BLAminus -127.6, -179.98 60.86, 89.79 -112.67, 27.22 299.87, 93.25 -61.87, -31.32 in-in in 8.6985 Saltbr-in 3.0559 HRD-in -91.14, -53.45 82.64, -3.08 in-in-in SNCiii in-in ActLoopNT-in 2.8642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -119.65, 152.15 APE9-dihe-in -136.18, 157.7 APE8-dihe-in -58.05, 115.06 APE8-rot-na 339.75 APE67-dihe-in -80.51, -24.68 -64.53, -28.52 APE12-dist-na 14.1508 APE11-dist-na 9.7097 APE10-dist-na 12.3903 APE9-dist-in 6.6287 Y505F PTR394 PTR394 XRAY 2.8 0.167 0.223 A 288.0 271.0 0 29 29 0 [[245, 496]] 1.0 3kmm Homo sapiens TYR_LCK_HUMAN TYR 1.6e-94 322.0 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck

Ligand: LHL

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name