Ligand: IE0

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 9FQSA
DFGout None 1 50.0% 8PYLAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 9FQSA P00533 701 1019 1210.0 A1IE0:61103 Type1.5_Back Active DFGin 6.1344 14.1921 BLAminus -132.91, -178.24 67.27, 86.84 -99.9, 25.54 296.52, 82.26 -59.0, -36.29 in-in in 8.6173 Saltbr-in 2.8903 HRD-in -69.4, -45.72 68.58, -3.7 in-in-in SNCiii in-in ActLoopNT-in 2.8593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 137.92 APE9-dihe-in -140.19, 151.4 APE8-dihe-in -80.21, 88.89 APE8-rot-na 33.48 APE67-dihe-in -69.87, -7.88 -52.66, -46.03 APE12-dist-na 12.1902 APE11-dist-na 9.3155 APE10-dist-na 9.9402 APE9-dist-in 6.3998 V948R None None XRAY 1.783 0.199 0.237 A 338.0 302.0 5 30 30 0 [[712, 970]] 1.0 9fqs TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR IGF1R IGF1R_HUMAN 8PYLAAA P08069 986 1270 1367.0 IE0:1301 Type2 Inactive DFGout 17.4898 8.8022 None -135.7, -153.05 -170.07, 104.78 -81.37, -21.74 213.38, 146.3 99.88, -176.88 out-out out 10.2584 Saltbr-out 5.0221 HRD-in -75.5, -46.79 77.95, -4.93 out-out-in SNCooi out-in ActLoopNT-out 18.1937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.72, 135.11 APE9-dihe-in -129.69, 131.01 APE8-dihe-in -77.6, 68.98 APE8-rot-na 32.9 APE67-dihe-in -67.64, -16.63 -60.37, -36.74 APE12-dist-na 13.7691 APE11-dist-na 9.55 APE10-dist-na 5.5807 APE9-dist-in 7.3672 None None None XRAY 2.93 0.191 0.249 AAA 321.0 277.0 8 30 30 0 [[999, 1268]] 1.0 8pyl TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor

Ligand: IE0

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 9FQSA
DFGout None 1 50.0% 8PYLAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TYR EGFR EGFR_HUMAN 9FQSA P00533 701 1019 1210.0 A1IE0:61103 Type1.5_Back Active DFGin 6.1344 14.1921 BLAminus -132.91, -178.24 67.27, 86.84 -99.9, 25.54 296.52, 82.26 -59.0, -36.29 in-in in 8.6173 Saltbr-in 2.8903 HRD-in -69.4, -45.72 68.58, -3.7 in-in-in SNCiii in-in ActLoopNT-in 2.8593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -71.39, 137.92 APE9-dihe-in -140.19, 151.4 APE8-dihe-in -80.21, 88.89 APE8-rot-na 33.48 APE67-dihe-in -69.87, -7.88 -52.66, -46.03 APE12-dist-na 12.1902 APE11-dist-na 9.3155 APE10-dist-na 9.9402 APE9-dist-in 6.3998 V948R None None XRAY 1.783 0.199 0.237 A 338.0 302.0 5 30 30 0 [[712, 970]] 1.0 9fqs Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-85 292.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR IGF1R IGF1R_HUMAN 8PYLAAA P08069 986 1270 1367.0 IE0:1301 Type2 Inactive DFGout 17.4898 8.8022 None -135.7, -153.05 -170.07, 104.78 -81.37, -21.74 213.38, 146.3 99.88, -176.88 out-out out 10.2584 Saltbr-out 5.0221 HRD-in -75.5, -46.79 77.95, -4.93 out-out-in SNCooi out-in ActLoopNT-out 18.1937 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -61.72, 135.11 APE9-dihe-in -129.69, 131.01 APE8-dihe-in -77.6, 68.98 APE8-rot-na 32.9 APE67-dihe-in -67.64, -16.63 -60.37, -36.74 APE12-dist-na 13.7691 APE11-dist-na 9.55 APE10-dist-na 5.5807 APE9-dist-in 7.3672 None None None XRAY 2.93 0.191 0.249 AAA 321.0 277.0 8 30 30 0 [[999, 1268]] 1.0 8pyl Homo sapiens TYR_IGF1R_HUMAN TYR 2.3e-95 324.8 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor

Ligand: IE0

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name