Ligand: 6ZV (Abemaciclib, Verzenio)

Total number of chains: 5
Active chains: 0
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% 7O7KA
DFGin ABAminus 1 20.0% 7O7JA
DFGin BLBplus 1 20.0% 5L2SA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC CDK4 CDK4_HUMAN 7SJ3A 2.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV Type1 2 - 295 0 TPO172 None Cyclin-dependent kinase 4
CMGC CDK6 CDK6_HUMAN 5L2SA 2.27 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 6ZV Type1 11 - 301 0 None None Cyclin-dependent kinase 6
CMGC DYRK1A DYR1A_HUMAN 7O7KA 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV, LI Type1, Allosteric 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7O7KB 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioi 6ZV, LI Type1, Allosteric 133 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC HIPK3 HIPK3_HUMAN 7O7JA 2.81 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV Type1 184 - 551 0 PTR359 None Homeodomain-interacting protein kinase 3

Ligand: 6ZV (Abemaciclib, Verzenio)

Total number of chains: 5
Active chains: 0
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% 7O7KA
DFGin ABAminus 1 20.0% 7O7JA
DFGin BLBplus 1 20.0% 5L2SA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK4 CDK4_HUMAN 7SJ3A 2.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV Type1 2 - 295 0 TPO172 None Cyclin-dependent kinase 4 Homo sapiens
CMGC CDK6 CDK6_HUMAN 5L2SA 2.27 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno 6ZV Type1 11 - 301 0 None None Cyclin-dependent kinase 6 Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 7O7KA 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV, LI Type1, Allosteric 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 7O7KB 1.82 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioi 6ZV, LI Type1, Allosteric 133 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC HIPK3 HIPK3_HUMAN 7O7JA 2.81 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii 6ZV Type1 184 - 551 0 PTR359 None Homeodomain-interacting protein kinase 3 Homo sapiens

Ligand: 6ZV (Abemaciclib, Verzenio)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Hover over column headers for tooltip help

Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism