KinCore

Ligand: 6ZV

Total number of chains: 5

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLAminus	3	7O7KA
DFGin	ABAminus	1	7O7JA
DFGin	BLBplus	1	5L2SA

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein
CMGC	CDK4	CDK4_HUMAN	7SJ3	2.51	Inactive	DFGin‑BLAminus	in-in	in-out	6ZV	Type1	2 - 295	0	X172	None	Cyclin-dependent kinase 4
CMGC	CDK6	CDK6_HUMAN	5L2S	2.27	Inactive	DFGin‑BLBplus	out-out	none-out	6ZV	Type1	11 - 301	13	None	None	Cyclin-dependent kinase 6
CMGC	DYRK1A	DYR1A_HUMAN	7O7K	1.82	Inactive	DFGin‑BLAminus	in-in	in-out	6ZV, LI	Type1, Allosteric	134 - 480	0	X321	None	Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC	DYRK1A	DYR1A_HUMAN	7O7K	1.82	Inactive	DFGin‑BLAminus	in-in	in-out	6ZV, LI	Type1, Allosteric	133 - 480	0	X321	None	Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC	HIPK3	HIPK3_HUMAN	7O7J	2.81	Inactive	DFGin‑ABAminus	in-in	in-out	6ZV	Type1	184 - 551	0	X359	None	Homeodomain-interacting protein kinase 3

Ligand: 6ZV

Total number of chains: 5

Spatial label	Dihedral label	Number of Chains	Representative
DFGin	BLAminus	3	7O7KA
DFGin	ABAminus	1	7O7JA
DFGin	BLBplus	1	5L2SA

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism
CMGC	CDK4	CDK4_HUMAN	7SJ3	2.51	Inactive	DFGin‑BLAminus	in-in	in-out	6ZV	Type1	2 - 295	0	X172	None	Cyclin-dependent kinase 4	Homo sapiens
CMGC	CDK6	CDK6_HUMAN	5L2S	2.27	Inactive	DFGin‑BLBplus	out-out	none-out	6ZV	Type1	11 - 301	13	None	None	Cyclin-dependent kinase 6	Homo sapiens
CMGC	DYRK1A	DYR1A_HUMAN	7O7K	1.82	Inactive	DFGin‑BLAminus	in-in	in-out	6ZV, LI	Type1, Allosteric	134 - 480	0	X321	None	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens
CMGC	DYRK1A	DYR1A_HUMAN	7O7K	1.82	Inactive	DFGin‑BLAminus	in-in	in-out	6ZV, LI	Type1, Allosteric	133 - 480	0	X321	None	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens
CMGC	HIPK3	HIPK3_HUMAN	7O7J	2.81	Inactive	DFGin‑ABAminus	in-in	in-out	6ZV	Type1	184 - 551	0	X359	None	Homeodomain-interacting protein kinase 3	Homo sapiens

Ligand: 6ZV

Total number of chains: 0

Spatial label	Dihedral label	Number of Chains	Representative

Database table as tsv

Family	Gene	UniprotID	PDB	Resolution	Activity	Spatial-Dihedral	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Unresolved residues in A-loop	Phosphorylation	Mutation	Protein	Organism