Ligand: 6HL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 6QG7A
DFGin BLAminus 1 50.0% 5J9YA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K7 MP2K7_HUMAN 6QG7A O14733 102 401 419.0 6HL:60501 Type1 Inactive DFGin 5.911 15.232 ABAminus -123.01, -51.98 -107.12, 111.08 -111.71, 38.94 316.9, 98.78 -70.4, -27.38 na-na na 8.997 Saltbr-na 5.576 HRD-in -77.58, -50.11 69.18, 12.05 na-in-out SNCaio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 133.85 APE9-dihe-na -74.73, -170.49 APE8-dihe-in -66.48, 132.0 APE8-rot-na 174.14 APE67-dihe-in -67.76, -29.49 -64.52, -21.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.864 APE9-dist-in 3.537 None None None XRAY 2.1 0.236 0.268 A 318 282 18 0 0 9 [[120, 380]] 1.0 6qg7 STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
TYR EGFR EGFR_HUMAN 5J9YA P00533 697 1019 1210.0 6HL:1101 Type1 Active DFGin 6.024 15.621 BLAminus -143.43, -160.74 49.91, 84.26 -101.22, 18.94 291.9, 123.66 -49.61, -50.61 in-in in 8.437 Saltbr-in 3.447 HRD-in -67.06, -45.86 64.69, -10.5 in-in-in SNCiii in-in ActLoopNT-in 3.061 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.4, 148.12 APE9-dihe-in -143.13, 151.2 APE8-dihe-in -85.49, 83.09 APE8-rot-na 35.02 APE67-dihe-in -71.5, -10.87 -57.34, -38.25 APE12-dist-na 11.356 APE11-dist-na 10.476 APE10-dist-na 10.43 APE9-dist-in 6.959 None None None XRAY 2.8 0.185 0.237 A 323 300 3 0 0 3 [[712, 970]] 1.0 5j9y TYR_EGFR_HUMAN TYR 7.7e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 6HL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 6QG7A
DFGin BLAminus 1 50.0% 5J9YA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
STE MAP2K7 MP2K7_HUMAN 6QG7A O14733 102 401 419.0 6HL:60501 Type1 Inactive DFGin 5.911 15.232 ABAminus -123.01, -51.98 -107.12, 111.08 -111.71, 38.94 316.9, 98.78 -70.4, -27.38 na-na na 8.997 Saltbr-na 5.576 HRD-in -77.58, -50.11 69.18, 12.05 na-in-out SNCaio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_nnoi APE10-dihe-na 999.0, 133.85 APE9-dihe-na -74.73, -170.49 APE8-dihe-in -66.48, 132.0 APE8-rot-na 174.14 APE67-dihe-in -67.76, -29.49 -64.52, -21.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.864 APE9-dist-in 3.537 None None None XRAY 2.1 0.236 0.268 A 318 282 18 0 0 9 [[120, 380]] 1.0 6qg7 Homo sapiens STE_MAP2K7_HUMAN STE 2.7e-80 275.4 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
TYR EGFR EGFR_HUMAN 5J9YA P00533 697 1019 1210.0 6HL:1101 Type1 Active DFGin 6.024 15.621 BLAminus -143.43, -160.74 49.91, 84.26 -101.22, 18.94 291.9, 123.66 -49.61, -50.61 in-in in 8.437 Saltbr-in 3.447 HRD-in -67.06, -45.86 64.69, -10.5 in-in-in SNCiii in-in ActLoopNT-in 3.061 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.4, 148.12 APE9-dihe-in -143.13, 151.2 APE8-dihe-in -85.49, 83.09 APE8-rot-na 35.02 APE67-dihe-in -71.5, -10.87 -57.34, -38.25 APE12-dist-na 11.356 APE11-dist-na 10.476 APE10-dist-na 10.43 APE9-dist-in 6.959 None None None XRAY 2.8 0.185 0.237 A 323 300 3 0 0 3 [[712, 970]] 1.0 5j9y Homo sapiens TYR_EGFR_HUMAN TYR 7.7e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor

Ligand: 6HL

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name