Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TKL | BRAF | BRAF_HUMAN | 4WO5A | P15056 | 448 | 721 | 766.0 | 324:801 | Type1.5_Back | Inactive | DFGin | 6.197 | 12.471 | BLAplus | -113.39, 171.89 | 60.4, 25.87 | -88.62, -20.81 | 62.14, 83.22 | -76.85, 162.27 | out-out | out | 11.855 | Saltbr-out | 10.947 | HRD-in | -61.99, -45.91 | 75.82, -24.69 | out-out-out | SNCooo | out-out | ActLoopNT-out | 6.802 | ActLoopCT-out | nonTYR | APEdihe_aaooo | APEdist_iooo | APE10-dihe-na | -106.86, 132.67 | APE9-dihe-na | -94.97, 98.91 | APE8-dihe-out | -154.69, -103.68 | APE8-rot-out | 172.98 | APE67-dihe-out | -59.88, -33.44 | 59.76, -29.06 | APE12-dist-in | 13.661 | APE11-dist-out | 17.614 | APE10-dist-out | 20.645 | APE9-dist-out | 12.338 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G | None | None | XRAY | 2.83 | 0.196 | 0.26 | A | 300 | 266 | 8 | 0 | 0 | 4 | [[457, 716]] | 1.0 | 4wo5 | TKL_BRAF_HUMAN | TKL | 5.9e-84 | 287.7 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 4WO5B | P15056 | 450 | 721 | 766.0 | 324:801 | Type1.5_Back | Inactive | DFGin | 6.888 | 12.867 | BLAplus | -140.91, 168.85 | 84.0, 47.56 | -114.71, 82.32 | 38.72, 99.17 | -44.17, -77.3 | out-none | out | 11.966 | Saltbr-none | 999.0 | HRD-in | -57.15, -60.67 | 87.46, -19.9 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 9.245 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -63.37 | APE8-dihe-in | -130.43, 79.93 | APE8-rot-in | 273.2 | APE67-dihe-in | -55.15, -30.0 | -52.46, -34.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.189 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G | None | None | XRAY | 2.83 | 0.196 | 0.26 | B | 300 | 257 | 15 | 0 | 0 | 15 | [[457, 716]] | 1.0 | 4wo5 | TKL_BRAF_HUMAN | TKL | 5.9e-84 | 287.7 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 3C4CA | P15056 | 448 | 721 | 766.0 | 324:60002 | Type1.5_Back | Inactive | DFGin | 5.638 | 13.547 | BLBplus | -139.33, -169.83 | 64.62, 39.85 | -103.64, 171.83 | 60.3, 95.42 | 83.99, 999.0 | out-out | out | 11.62 | Saltbr-out | 8.693 | HRD-in | -73.87, -57.97 | 102.26, -19.82 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, -163.04 | APE9-dihe-na | -121.17, -138.04 | APE8-dihe-in | -92.13, 91.4 | APE8-rot-out | 47.35 | APE67-dihe-in | -63.77, -25.31 | -68.49, -17.72 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.55 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E | None | None | XRAY | 2.57 | 0.261 | 0.303 | A | 280 | 257 | 17 | 0 | 0 | 17 | [[457, 716]] | 1.0 | 3c4c | TKL_BRAF_HUMAN | TKL | 4.5e-84 | 288.0 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 3C4CB | P15056 | 448 | 721 | 766.0 | 324:60003 | Type1.5_Back | Inactive | DFGout | 17.121 | 11.474 | None | -158.07, 167.38 | -86.45, 172.73 | 27.7, 999.0 | 226.78, 93.67 | 999.0, 999.0 | in-out | in | 9.671 | Saltbr-out | 7.076 | HRD-in | -64.15, -34.82 | 70.63, -1.96 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnno | APE10-dihe-na | 999.0, 56.1 | APE9-dihe-na | 175.12, 83.72 | APE8-dihe-in | -104.65, 152.29 | APE8-rot-in | 256.49 | APE67-dihe-in | -58.95, -27.9 | -70.54, -27.24 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 8.729 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E | None | None | XRAY | 2.57 | 0.261 | 0.303 | B | 280 | 256 | 18 | 0 | 0 | 18 | [[457, 716]] | 1.0 | 3c4c | TKL_BRAF_HUMAN | TKL | 4.5e-84 | 288.0 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | RAF1 | RAF1_HUMAN | 9O0UG | P04049 | 341 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.643 | 14.536 | BLAminus | -137.03, -164.72 | 64.05, 59.07 | -91.31, 23.03 | 298.27, 111.42 | -70.02, -22.85 | in-in | in | 8.466 | Saltbr-in | 2.793 | HRD-in | -67.69, -46.18 | 73.87, -6.26 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.408 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | -147.61, -172.9 | APE9-dihe-na | 96.11, -111.47 | APE8-dihe-in | -121.52, 159.07 | APE8-rot-out | 179.33 | APE67-dihe-in | -61.77, -27.13 | -108.62, -7.48 | APE12-dist-in | 9.328 | APE11-dist-in | 9.035 | APE10-dist-out | 10.478 | APE9-dist-out | 9.744 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | G | 280 | 265 | 9 | 0 | 0 | 9 | [[349, 608]] | 1.0 | 9o0u | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VG | P04049 | 341 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.652 | 14.526 | BLAminus | -136.91, -164.75 | 63.88, 58.79 | -91.51, 23.22 | 298.64, 111.76 | -69.75, -22.63 | in-in | in | 8.529 | Saltbr-in | 2.827 | HRD-in | -68.13, -46.19 | 73.7, -5.88 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.362 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | -144.93, -171.41 | APE9-dihe-na | 95.72, -110.34 | APE8-dihe-in | -121.89, 159.4 | APE8-rot-out | 179.42 | APE67-dihe-in | -62.17, -27.08 | -108.22, -7.65 | APE12-dist-in | 9.379 | APE11-dist-in | 8.988 | APE10-dist-out | 10.404 | APE9-dist-out | 9.661 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | G | 280 | 265 | 9 | 0 | 0 | 9 | [[349, 608]] | 1.0 | 9o0v | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0UE | P04049 | 339 | 613 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.955 | 13.419 | BLAplus | -138.96, -169.14 | 62.02, 34.27 | -105.27, 31.97 | 55.75, 93.21 | -64.59, -47.5 | out-none | out | 11.632 | Saltbr-none | 999.0 | HRD-in | -66.55, -46.99 | 72.02, -8.83 | none-none-out | SNCnno | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -79.43 | APE8-dihe-in | -132.83, 160.57 | APE8-rot-out | 180.68 | APE67-dihe-in | -62.16, -27.71 | -107.14, -6.5 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.74 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | E | 280 | 258 | 17 | 0 | 0 | 17 | [[349, 608]] | 1.0 | 9o0u | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VE | P04049 | 339 | 613 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.802 | 13.34 | BLAplus | -138.88, -169.03 | 61.87, 34.79 | -104.64, 32.35 | 56.09, 93.36 | -64.43, -47.67 | out-none | out | 11.585 | Saltbr-none | 999.0 | HRD-in | -66.6, -47.0 | 72.05, -8.97 | none-none-out | SNCnno | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | 56.8, 24.32 | APE9-dihe-na | -101.33, -80.31 | APE8-dihe-in | -132.61, 160.7 | APE8-rot-out | 180.75 | APE67-dihe-in | -62.26, -27.57 | -106.96, -6.66 | APE12-dist-in | 11.262 | APE11-dist-in | 9.041 | APE10-dist-out | 12.024 | APE9-dist-out | 9.452 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | E | 280 | 261 | 14 | 0 | 0 | 14 | [[349, 608]] | 1.0 | 9o0v | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0UC | P04049 | 339 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.412 | 14.92 | BLBminus | -135.2, -162.93 | 65.39, 47.79 | -89.17, 153.49 | 305.13, 119.24 | 148.83, -36.3 | in-in | in | 8.112 | Saltbr-in | 3.108 | HRD-in | -65.51, -42.52 | 74.23, -8.63 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.274 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnoo | APE10-dihe-na | 999.0, -140.95 | APE9-dihe-na | 87.04, -108.57 | APE8-dihe-in | -126.35, 163.82 | APE8-rot-out | 179.91 | APE67-dihe-in | -66.05, -28.24 | -108.28, -15.46 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-out | 9.537 | APE9-dist-out | 7.844 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | C | 280 | 264 | 12 | 0 | 0 | 12 | [[349, 608]] | 1.0 | 9o0u | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VC | P04049 | 339 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.507 | 14.848 | BLBminus | -135.62, -163.14 | 65.12, 48.02 | -88.94, 153.23 | 304.77, 118.58 | 148.73, -35.99 | in-in | in | 8.164 | Saltbr-in | 3.344 | HRD-in | -65.49, -42.82 | 73.84, -8.92 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.343 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnoo | APE10-dihe-na | 999.0, -150.01 | APE9-dihe-na | 93.34, -107.4 | APE8-dihe-in | -126.38, 163.35 | APE8-rot-out | 180.01 | APE67-dihe-in | -65.89, -28.16 | -108.44, -15.01 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-out | 9.402 | APE9-dist-out | 7.912 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | C | 280 | 264 | 12 | 0 | 0 | 12 | [[349, 608]] | 1.0 | 9o0v | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0UA | P04049 | 339 | 612 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.49 | 13.425 | BLBplus | -137.77, -168.21 | 60.54, 23.67 | -97.39, 164.85 | 62.85, 94.03 | 74.33, 173.3 | out-none | out | 11.636 | Saltbr-none | 999.0 | HRD-in | -67.32, -47.26 | 72.53, -10.19 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 8.521 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_oooo | APE10-dihe-na | -79.91, 164.26 | APE9-dihe-na | 133.94, -179.25 | APE8-dihe-in | -151.13, 161.47 | APE8-rot-out | 181.14 | APE67-dihe-in | -63.28, -28.75 | -107.76, -7.41 | APE12-dist-out | 21.288 | APE11-dist-out | 15.359 | APE10-dist-out | 15.218 | APE9-dist-out | 10.016 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | A | 280 | 267 | 7 | 0 | 0 | 7 | [[349, 608]] | 1.0 | 9o0u | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VA | P04049 | 339 | 612 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.612 | 13.541 | BLBplus | -137.53, -168.14 | 60.68, 23.81 | -97.37, 165.11 | 62.5, 93.91 | 74.63, 173.9 | out-none | out | 11.518 | Saltbr-none | 999.0 | HRD-in | -67.23, -47.12 | 72.36, -10.39 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 8.582 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_oioo | APE10-dihe-na | -121.31, 23.23 | APE9-dihe-na | -94.2, -61.86 | APE8-dihe-in | -150.39, 162.26 | APE8-rot-out | 181.1 | APE67-dihe-in | -63.35, -28.52 | -106.79, -7.22 | APE12-dist-out | 14.056 | APE11-dist-in | 11.333 | APE10-dist-out | 13.018 | APE9-dist-out | 9.521 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | A | 280 | 266 | 8 | 0 | 0 | 8 | [[349, 608]] | 1.0 | 9o0v | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| TKL | BRAF | BRAF_HUMAN | 4WO5A | P15056 | 448 | 721 | 766.0 | 324:801 | Type1.5_Back | Inactive | DFGin | 6.197 | 12.471 | BLAplus | -113.39, 171.89 | 60.4, 25.87 | -88.62, -20.81 | 62.14, 83.22 | -76.85, 162.27 | out-out | out | 11.855 | Saltbr-out | 10.947 | HRD-in | -61.99, -45.91 | 75.82, -24.69 | out-out-out | SNCooo | out-out | ActLoopNT-out | 6.802 | ActLoopCT-out | nonTYR | APEdihe_aaooo | APEdist_iooo | APE10-dihe-na | -106.86, 132.67 | APE9-dihe-na | -94.97, 98.91 | APE8-dihe-out | -154.69, -103.68 | APE8-rot-out | 172.98 | APE67-dihe-out | -59.88, -33.44 | 59.76, -29.06 | APE12-dist-in | 13.661 | APE11-dist-out | 17.614 | APE10-dist-out | 20.645 | APE9-dist-out | 12.338 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G | None | None | XRAY | 2.83 | 0.196 | 0.26 | A | 300 | 266 | 8 | 0 | 0 | 4 | [[457, 716]] | 1.0 | 4wo5 | Homo sapiens | TKL_BRAF_HUMAN | TKL | 5.9e-84 | 287.7 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 4WO5B | P15056 | 450 | 721 | 766.0 | 324:801 | Type1.5_Back | Inactive | DFGin | 6.888 | 12.867 | BLAplus | -140.91, 168.85 | 84.0, 47.56 | -114.71, 82.32 | 38.72, 99.17 | -44.17, -77.3 | out-none | out | 11.966 | Saltbr-none | 999.0 | HRD-in | -57.15, -60.67 | 87.46, -19.9 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 9.245 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -63.37 | APE8-dihe-in | -130.43, 79.93 | APE8-rot-in | 273.2 | APE67-dihe-in | -55.15, -30.0 | -52.46, -34.18 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.189 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G | None | None | XRAY | 2.83 | 0.196 | 0.26 | B | 300 | 257 | 15 | 0 | 0 | 15 | [[457, 716]] | 1.0 | 4wo5 | Homo sapiens | TKL_BRAF_HUMAN | TKL | 5.9e-84 | 287.7 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 3C4CA | P15056 | 448 | 721 | 766.0 | 324:60002 | Type1.5_Back | Inactive | DFGin | 5.638 | 13.547 | BLBplus | -139.33, -169.83 | 64.62, 39.85 | -103.64, 171.83 | 60.3, 95.42 | 83.99, 999.0 | out-out | out | 11.62 | Saltbr-out | 8.693 | HRD-in | -73.87, -57.97 | 102.26, -19.82 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, -163.04 | APE9-dihe-na | -121.17, -138.04 | APE8-dihe-in | -92.13, 91.4 | APE8-rot-out | 47.35 | APE67-dihe-in | -63.77, -25.31 | -68.49, -17.72 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.55 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E | None | None | XRAY | 2.57 | 0.261 | 0.303 | A | 280 | 257 | 17 | 0 | 0 | 17 | [[457, 716]] | 1.0 | 3c4c | Homo sapiens | TKL_BRAF_HUMAN | TKL | 4.5e-84 | 288.0 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | BRAF | BRAF_HUMAN | 3C4CB | P15056 | 448 | 721 | 766.0 | 324:60003 | Type1.5_Back | Inactive | DFGout | 17.121 | 11.474 | None | -158.07, 167.38 | -86.45, 172.73 | 27.7, 999.0 | 226.78, 93.67 | 999.0, 999.0 | in-out | in | 9.671 | Saltbr-out | 7.076 | HRD-in | -64.15, -34.82 | 70.63, -1.96 | out-none-out | SNCono | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaiii | APEdist_nnno | APE10-dihe-na | 999.0, 56.1 | APE9-dihe-na | 175.12, 83.72 | APE8-dihe-in | -104.65, 152.29 | APE8-rot-in | 256.49 | APE67-dihe-in | -58.95, -27.9 | -70.54, -27.24 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 8.729 | I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E | None | None | XRAY | 2.57 | 0.261 | 0.303 | B | 280 | 256 | 18 | 0 | 0 | 18 | [[457, 716]] | 1.0 | 3c4c | Homo sapiens | TKL_BRAF_HUMAN | TKL | 4.5e-84 | 288.0 | 4 | 267 | 264 | 593 | 594 | 595 | 597 | 599 | 483 | 501 | 505 | 573 | 575 | 574 | 576 | 638 | 623 | 618 | 617 | 616 | 615 | 614 | 613 | 612 | 530 | Serine/threonine-protein kinase B-raf |
| TKL | RAF1 | RAF1_HUMAN | 9O0UG | P04049 | 341 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.643 | 14.536 | BLAminus | -137.03, -164.72 | 64.05, 59.07 | -91.31, 23.03 | 298.27, 111.42 | -70.02, -22.85 | in-in | in | 8.466 | Saltbr-in | 2.793 | HRD-in | -67.69, -46.18 | 73.87, -6.26 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.408 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | -147.61, -172.9 | APE9-dihe-na | 96.11, -111.47 | APE8-dihe-in | -121.52, 159.07 | APE8-rot-out | 179.33 | APE67-dihe-in | -61.77, -27.13 | -108.62, -7.48 | APE12-dist-in | 9.328 | APE11-dist-in | 9.035 | APE10-dist-out | 10.478 | APE9-dist-out | 9.744 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | G | 280 | 265 | 9 | 0 | 0 | 9 | [[349, 608]] | 1.0 | 9o0u | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VG | P04049 | 341 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.652 | 14.526 | BLAminus | -136.91, -164.75 | 63.88, 58.79 | -91.51, 23.22 | 298.64, 111.76 | -69.75, -22.63 | in-in | in | 8.529 | Saltbr-in | 2.827 | HRD-in | -68.13, -46.19 | 73.7, -5.88 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.362 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | -144.93, -171.41 | APE9-dihe-na | 95.72, -110.34 | APE8-dihe-in | -121.89, 159.4 | APE8-rot-out | 179.42 | APE67-dihe-in | -62.17, -27.08 | -108.22, -7.65 | APE12-dist-in | 9.379 | APE11-dist-in | 8.988 | APE10-dist-out | 10.404 | APE9-dist-out | 9.661 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | G | 280 | 265 | 9 | 0 | 0 | 9 | [[349, 608]] | 1.0 | 9o0v | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0UE | P04049 | 339 | 613 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.955 | 13.419 | BLAplus | -138.96, -169.14 | 62.02, 34.27 | -105.27, 31.97 | 55.75, 93.21 | -64.59, -47.5 | out-none | out | 11.632 | Saltbr-none | 999.0 | HRD-in | -66.55, -46.99 | 72.02, -8.83 | none-none-out | SNCnno | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnno | APE10-dihe-na | 999.0, 999.0 | APE9-dihe-na | 999.0, -79.43 | APE8-dihe-in | -132.83, 160.57 | APE8-rot-out | 180.68 | APE67-dihe-in | -62.16, -27.71 | -107.14, -6.5 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-none | 999.0 | APE9-dist-out | 9.74 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | E | 280 | 258 | 17 | 0 | 0 | 17 | [[349, 608]] | 1.0 | 9o0u | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VE | P04049 | 339 | 613 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.802 | 13.34 | BLAplus | -138.88, -169.03 | 61.87, 34.79 | -104.64, 32.35 | 56.09, 93.36 | -64.43, -47.67 | out-none | out | 11.585 | Saltbr-none | 999.0 | HRD-in | -66.6, -47.0 | 72.05, -8.97 | none-none-out | SNCnno | none-out | ActLoopNT-none | 999.0 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_iioo | APE10-dihe-na | 56.8, 24.32 | APE9-dihe-na | -101.33, -80.31 | APE8-dihe-in | -132.61, 160.7 | APE8-rot-out | 180.75 | APE67-dihe-in | -62.26, -27.57 | -106.96, -6.66 | APE12-dist-in | 11.262 | APE11-dist-in | 9.041 | APE10-dist-out | 12.024 | APE9-dist-out | 9.452 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | E | 280 | 261 | 14 | 0 | 0 | 14 | [[349, 608]] | 1.0 | 9o0v | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0UC | P04049 | 339 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.412 | 14.92 | BLBminus | -135.2, -162.93 | 65.39, 47.79 | -89.17, 153.49 | 305.13, 119.24 | 148.83, -36.3 | in-in | in | 8.112 | Saltbr-in | 3.108 | HRD-in | -65.51, -42.52 | 74.23, -8.63 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.274 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnoo | APE10-dihe-na | 999.0, -140.95 | APE9-dihe-na | 87.04, -108.57 | APE8-dihe-in | -126.35, 163.82 | APE8-rot-out | 179.91 | APE67-dihe-in | -66.05, -28.24 | -108.28, -15.46 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-out | 9.537 | APE9-dist-out | 7.844 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | C | 280 | 264 | 12 | 0 | 0 | 12 | [[349, 608]] | 1.0 | 9o0u | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VC | P04049 | 339 | 614 | 648.0 | 324:701 | Type1 | Inactive | DFGin | 6.507 | 14.848 | BLBminus | -135.62, -163.14 | 65.12, 48.02 | -88.94, 153.23 | 304.77, 118.58 | 148.73, -35.99 | in-in | in | 8.164 | Saltbr-in | 3.344 | HRD-in | -65.49, -42.82 | 73.84, -8.92 | in-in-out | SNCiio | in-out | ActLoopNT-in | 3.343 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_nnoo | APE10-dihe-na | 999.0, -150.01 | APE9-dihe-na | 93.34, -107.4 | APE8-dihe-in | -126.38, 163.35 | APE8-rot-out | 180.01 | APE67-dihe-in | -65.89, -28.16 | -108.44, -15.01 | APE12-dist-none | 999.0 | APE11-dist-none | 999.0 | APE10-dist-out | 9.402 | APE9-dist-out | 7.912 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | C | 280 | 264 | 12 | 0 | 0 | 12 | [[349, 608]] | 1.0 | 9o0v | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0UA | P04049 | 339 | 612 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.49 | 13.425 | BLBplus | -137.77, -168.21 | 60.54, 23.67 | -97.39, 164.85 | 62.85, 94.03 | 74.33, 173.3 | out-none | out | 11.636 | Saltbr-none | 999.0 | HRD-in | -67.32, -47.26 | 72.53, -10.19 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 8.521 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_oooo | APE10-dihe-na | -79.91, 164.26 | APE9-dihe-na | 133.94, -179.25 | APE8-dihe-in | -151.13, 161.47 | APE8-rot-out | 181.14 | APE67-dihe-in | -63.28, -28.75 | -107.76, -7.41 | APE12-dist-out | 21.288 | APE11-dist-out | 15.359 | APE10-dist-out | 15.218 | APE9-dist-out | 10.016 | Y340D,Y341D | None | None | XRAY | 2.91 | 0.232 | 0.264 | A | 280 | 267 | 7 | 0 | 0 | 7 | [[349, 608]] | 1.0 | 9o0u | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| TKL | RAF1 | RAF1_HUMAN | 9O0VA | P04049 | 339 | 612 | 648.0 | 324:701 | Type1.5_Back | Inactive | DFGin | 5.612 | 13.541 | BLBplus | -137.53, -168.14 | 60.68, 23.81 | -97.37, 165.11 | 62.5, 93.91 | 74.63, 173.9 | out-none | out | 11.518 | Saltbr-none | 999.0 | HRD-in | -67.23, -47.12 | 72.36, -10.39 | none-out-out | SNCnoo | out-out | ActLoopNT-out | 8.582 | ActLoopCT-out | nonTYR | APEdihe_aaioi | APEdist_oioo | APE10-dihe-na | -121.31, 23.23 | APE9-dihe-na | -94.2, -61.86 | APE8-dihe-in | -150.39, 162.26 | APE8-rot-out | 181.1 | APE67-dihe-in | -63.35, -28.52 | -106.79, -7.22 | APE12-dist-out | 14.056 | APE11-dist-in | 11.333 | APE10-dist-out | 13.018 | APE9-dist-out | 9.521 | Y340D,Y341D | None | None | XRAY | 3.5 | 0.208 | 0.254 | A | 280 | 266 | 8 | 0 | 0 | 8 | [[349, 608]] | 1.0 | 9o0v | Homo sapiens | TKL_RAF1_HUMAN | TKL | 2.6e-81 | 279.0 | 3 | 266 | 264 | 485 | 486 | 487 | 489 | 491 | 375 | 393 | 397 | 465 | 467 | 466 | 468 | 530 | 515 | 510 | 509 | 508 | 507 | 506 | 505 | 504 | 422 | RAF proto-oncogene serine/threonine-protein kinase |
| Spatial label | Dihedral label | Number of Chains | Percent | Representative |
|---|
Hover over column headers for tooltip help
| Group | Gene | SwissprotID | PDB | UniprotID | First_obs_res | Last_obs_res | Length_Unp | Ligand | Ligand_type | Activity_label | Spatial_label | Phe_Glu4_dis | Phe_Lys_dis | Dihedral_label | XDFG φ,ψ |
DFG-Asp φ,ψ |
DFG-Phe φ,ψ |
DFG-Phe χ1,χ2 |
DFG-Gly φ,ψ |
ChelixSaltbr_label | Chelix_label | Lys_Glu_dis | Saltbr_label | LysNZ_GluOE_dis | HRD_label | His φ,ψ | Arg φ,ψ | SNC_label | SNCpymol_label | ActLoop_label | ActLoopNT_label | DFG6_XHRD_dis | ActLoopCT_label | APEtype | APEdihe_label | APEdist_label | APE10_dihe_label | APE10 φ,ψ | APE9_dihe_label | APE9 φ,ψ | APE8_dihe_label | APE8 φ,ψ | APE8_rotamer_label | APE8 χ1 | APE67_label | APE6 φ,ψ | APE7 φ,ψ | APE12_dist_label | APE12_DFG4_dis | APE11_dist_label | APE11_DFG4_dis | APE10_dist_label | APE10_DFG4_dis | APE9_dist_label | APE9_Arg_dis | Chain_mut | Chain_phos | Modified_aa | Method | Resolution | Rvalue | FreeRvalue | Chain_id | ChainLen | Ordered_residues | DomainBreak | ActLoopLength | ActLoopResolvedResidues | ActLoopDisorderedResidues | Kinase_domains_Unp | N_Kinase_domains_Unp | pdb | Species | Kincore_name | hmm | Evalue | Score | hmmbeg | hmmend | hmmlen | XDFGnum | DFGnum | PHEnum | DFG4num | DFG6num | LYSnum | GLUnum | GLU4num | XHRDnum | ARGnum | HRDnum | HRDaspnum | aFaspnum | APEnum | APE6num | APE7num | APE8num | APE9num | APE10num | APE11num | APE12num | Hinge1num | Protein_name |
|---|