TKL_TGFBR1 (TGF-beta receptor type-1)

Total number of chains: 59
Active chains: 46
Uniprot: TGFR1_HUMAN
Kinase Domain Residues: 205 - 494
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 59 100.0% AF-P36897-K1A

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Gene PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TGFBR1 5E8UA P36897 200 502 503.0 No_ligand No_ligand Active DFGin 7.2504 14.2389 BLAminus -134.62, -172.63 56.13, 81.95 -101.29, 16.47 292.48, 105.22 -57.91, -29.22 in-in in 7.8868 Saltbr-in 2.9459 HRD-in -72.05, -48.87 69.51, 7.62 in-in-in SNCiii in-in ActLoopNT-in 2.9688 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.25, 153.37 APE9-dihe-na 113.03, -170.78 APE8-dihe-in -89.61, 116.01 APE8-rot-in 305.95 APE67-dihe-in -56.91, -33.28 -47.65, -46.01 APE12-dist-in 13.1407 APE11-dist-in 12.5219 APE10-dist-in 6.4804 APE9-dist-in 3.9582 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 2.03 0.181 0.223 A 307.0 303.0 0 32 32 0 [[205, 494]] 1.0 5e8u TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 4X2NA P36897 200 501 503.0 No_ligand No_ligand Active DFGin 6.1503 13.2 BLAminus -127.58, -171.48 51.56, 55.64 -81.72, 7.99 306.47, 9.87 -57.69, -30.68 in-in in 7.7458 Saltbr-in 3.1369 HRD-in -73.45, -50.82 74.64, -6.69 in-in-in SNCiii in-in ActLoopNT-in 2.9883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.64, 175.91 APE9-dihe-na 96.93, 176.28 APE8-dihe-in -81.13, 124.7 APE8-rot-in 305.67 APE67-dihe-in -55.99, -35.77 -56.51, -42.26 APE12-dist-in 11.7879 APE11-dist-in 11.8763 APE10-dist-in 6.1938 APE9-dist-in 3.7123 None None None XRAY 1.8 0.163 0.201 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2n TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5E8SA P36897 200 498 503.0 No_ligand No_ligand Active DFGin 6.227 13.3447 BLAminus -130.71, -170.38 50.26, 56.29 -81.51, 7.19 302.58, 10.42 -59.69, -25.71 in-in in 7.7497 Saltbr-in 3.0983 HRD-in -75.18, -50.46 75.3, -6.11 in-in-in SNCiii in-in ActLoopNT-in 2.9421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.12, 158.63 APE9-dihe-na 109.47, 177.89 APE8-dihe-in -83.28, 125.6 APE8-rot-in 301.61 APE67-dihe-in -57.6, -32.67 -59.04, -39.92 APE12-dist-in 13.3842 APE11-dist-in 12.4174 APE10-dist-in 6.3031 APE9-dist-in 3.6774 None None None XRAY 1.45 0.172 0.188 A 306.0 299.0 0 32 32 0 [[205, 494]] 1.0 5e8s TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 AF-P36897-K1A P36897 197 502 503.0 No_ligand No_ligand Active DFGin 6.0972 12.6974 BLAminus -127.47, -177.39 59.98, 50.67 -75.64, 9.99 303.25, 0.83 -67.03, -14.65 in-in in 7.7504 Saltbr-in 2.6308 HRD-in -79.18, -43.89 66.79, -8.16 in-in-in SNCiii in-in ActLoopNT-in 3.0147 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.74, 159.13 APE9-dihe-na 99.19, -175.01 APE8-dihe-in -81.52, 117.2 APE8-rot-in 304.32 APE67-dihe-in -58.11, -28.29 -49.21, -42.7 APE12-dist-in 13.0338 APE11-dist-in 12.4755 APE10-dist-in 6.3484 APE9-dist-in 3.7811 None None None AF2 -1.0 1.0 1.0 A 306.0 306.0 0 32 32 0 [[205, 494]] 1.0 AF-P36897-K1 TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 AF-P36897-K3A P36897 197 502 503.0 No_ligand No_ligand Active DFGin 6.3884 12.8818 BLAminus -127.89, -179.35 58.97, 55.86 -76.18, 6.96 301.47, 0.09 -63.41, -19.74 in-in in 8.0954 Saltbr-in 2.6745 HRD-in -77.05, -40.27 65.4, -16.45 in-in-in SNCiii in-in ActLoopNT-in 2.8499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.36, 158.96 APE9-dihe-na 107.71, -175.1 APE8-dihe-in -94.3, 114.61 APE8-rot-in 303.53 APE67-dihe-in -61.67, -24.01 -41.02, -46.98 APE12-dist-in 11.2123 APE11-dist-in 11.8142 APE10-dist-in 5.9249 APE9-dist-in 3.7002 None None None AF2 -1.0 1.0 1.0 A 306.0 306.0 0 32 32 0 [[205, 494]] 1.0 AF-P36897-K3 TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5E8TA P36897 200 499 503.0 No_ligand No_ligand Active DFGin 6.1295 13.1171 BLAminus -129.7, -170.36 54.3, 58.56 -85.47, 9.03 309.14, 5.15 -56.74, -27.28 in-in in 7.8399 Saltbr-in 2.9399 HRD-in -72.25, -51.54 76.95, -4.64 in-in-in SNCiii in-in ActLoopNT-in 2.9687 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.56, -31.05 APE9-dihe-na -81.1, -159.38 APE8-dihe-in -84.33, 122.67 APE8-rot-in 299.0 APE67-dihe-in -55.04, -35.69 -53.58, -44.7 APE12-dist-in 13.0667 APE11-dist-in 12.2817 APE10-dist-in 6.2375 APE9-dist-in 3.7905 T204D None None XRAY 1.7 0.17 0.19 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e8t TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1IASA P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.7211 12.7225 BLAminus -151.41, 164.95 71.98, 88.97 -106.86, 22.49 311.89, 1.41 -60.78, -26.26 in-in in 8.2398 Saltbr-in 2.7897 HRD-in -63.37, -49.76 71.64, 8.78 in-in-in SNCiii in-in ActLoopNT-in 2.9738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.42, 172.85 APE9-dihe-na 97.41, 166.83 APE8-dihe-in -62.29, 121.18 APE8-rot-in 307.67 APE67-dihe-in -45.67, -30.78 -49.33, -54.47 APE12-dist-in 11.4524 APE11-dist-in 11.6294 APE10-dist-in 6.1724 APE9-dist-in 4.1313 None None None XRAY 2.9 0.255 0.284 A 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1IASB P36897 171 501 503.0 No_ligand No_ligand Active DFGin 6.6521 12.7075 BLAminus -150.79, 165.66 71.53, 88.91 -106.55, 22.01 312.14, 1.23 -60.97, -25.51 in-in in 8.2406 Saltbr-in 2.7993 HRD-in -64.38, -48.85 71.21, 7.9 in-in-in SNCiii in-in ActLoopNT-in 3.0054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.79, 173.68 APE9-dihe-na 99.72, 167.49 APE8-dihe-in -63.26, 121.22 APE8-rot-in 308.35 APE67-dihe-in -44.49, -32.42 -49.46, -55.33 APE12-dist-in 10.321 APE11-dist-in 11.6277 APE10-dist-in 6.2406 APE9-dist-in 4.0495 None None None XRAY 2.9 0.255 0.284 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 1ias TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1IASC P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.5902 12.7106 BLAminus -150.31, 164.7 71.4, 89.07 -106.94, 23.22 312.6, 1.77 -61.3, -25.67 in-in in 8.1971 Saltbr-in 2.7993 HRD-in -63.0, -50.37 71.83, 9.79 in-in-in SNCiii in-in ActLoopNT-in 3.0126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.75, 170.21 APE9-dihe-na 100.55, 167.25 APE8-dihe-in -63.65, 121.53 APE8-rot-in 308.64 APE67-dihe-in -44.33, -30.7 -49.24, -56.44 APE12-dist-in 11.3487 APE11-dist-in 11.7592 APE10-dist-in 6.2222 APE9-dist-in 4.1504 None None None XRAY 2.9 0.255 0.284 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1IASD P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.5942 12.7426 BLAminus -152.15, 165.79 70.83, 87.83 -105.27, 21.55 312.92, 0.98 -60.27, -25.54 in-in in 8.1886 Saltbr-in 2.7745 HRD-in -64.51, -48.18 71.39, 8.63 in-in-in SNCiii in-in ActLoopNT-in 2.9927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.69, 169.96 APE9-dihe-na 98.27, 166.26 APE8-dihe-in -61.5, 120.34 APE8-rot-in 308.37 APE67-dihe-in -44.16, -31.51 -48.36, -56.13 APE12-dist-in 10.7317 APE11-dist-in 11.7841 APE10-dist-in 6.1802 APE9-dist-in 4.0397 None None None XRAY 2.9 0.255 0.284 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1IASE P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.6847 12.7375 BLAminus -151.39, 165.15 70.82, 89.42 -106.94, 21.97 311.98, 2.05 -61.66, -24.41 in-in in 8.2265 Saltbr-in 2.8032 HRD-in -61.95, -50.33 72.19, 7.85 in-in-in SNCiii in-in ActLoopNT-in 3.0078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.31, 173.9 APE9-dihe-na 98.05, 167.39 APE8-dihe-in -64.1, 121.3 APE8-rot-in 308.19 APE67-dihe-in -45.93, -31.42 -49.14, -54.62 APE12-dist-in 11.6357 APE11-dist-in 11.5052 APE10-dist-in 6.1489 APE9-dist-in 4.002 None None None XRAY 2.9 0.255 0.284 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5E8XA P36897 200 503 503.0 STU:601 Type1 Active DFGin 7.4008 13.7714 BLAminus -132.02, 177.79 68.95, 84.86 -101.89, 20.89 298.69, 99.78 -60.9, -22.78 in-in in 7.6457 Saltbr-in 3.3162 HRD-in -78.83, -50.32 78.23, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.9268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 171.93 APE9-dihe-na 104.3, 177.57 APE8-dihe-in -80.96, 119.4 APE8-rot-in 304.53 APE67-dihe-in -55.33, -34.35 -53.44, -41.29 APE12-dist-in 11.7091 APE11-dist-in 11.9272 APE10-dist-in 6.2584 APE9-dist-in 3.9463 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 1.45 0.191 0.21 A 307.0 304.0 0 32 32 0 [[205, 494]] 1.0 5e8x TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5E90A P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 7.0329 13.9683 BLAminus -132.44, -170.95 59.07, 73.91 -100.08, 11.67 293.12, 109.78 -58.9, -27.5 in-in in 7.7319 Saltbr-in 2.8651 HRD-in -62.69, -55.46 77.29, -2.06 in-in-in SNCiii in-in ActLoopNT-in 2.8722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.74, -31.43 APE9-dihe-na -82.55, -164.68 APE8-dihe-in -74.68, 122.19 APE8-rot-in 303.81 APE67-dihe-in -54.67, -36.7 -55.17, -42.7 APE12-dist-in 12.5936 APE11-dist-in 11.8996 APE10-dist-in 5.8869 APE9-dist-in 3.841 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 2.05 0.178 0.218 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e90 TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5USQA P36897 200 498 503.0 8LY:500 Type1 Active DFGin 6.294 13.4506 BLAminus -128.65, -178.48 58.74, 56.74 -84.73, 2.3 308.58, 3.38 -59.48, -22.95 in-in in 7.7524 Saltbr-in 3.1908 HRD-in -74.99, -53.41 77.78, -10.32 in-in-in SNCiii in-in ActLoopNT-in 2.9203 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.34, -32.16 APE9-dihe-na -75.45, -164.79 APE8-dihe-in -80.15, 126.14 APE8-rot-in 305.26 APE67-dihe-in -52.52, -34.72 -59.83, -43.81 APE12-dist-in 13.0242 APE11-dist-in 12.0079 APE10-dist-in 6.1582 APE9-dist-in 3.5574 None None None XRAY 2.55 0.182 0.231 A 299.0 299.0 0 32 32 0 [[205, 494]] 1.0 5usq TKL_TGFBR1_HUMAN TKL 3e-85 291.9 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5FRIA P36897 200 498 503.0 ZUQ:61501 Type1 Active DFGin 5.986 12.349 BLAminus -129.47, -173.22 60.99, 71.38 -101.21, 12.39 307.22, 5.28 -67.89, -22.52 in-in in 7.7579 Saltbr-in 2.8572 HRD-in -78.14, -52.35 77.86, -1.93 in-in-in SNCiii in-in ActLoopNT-in 2.9265 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.89, -25.51 APE9-dihe-na -92.81, -153.48 APE8-dihe-in -86.34, 123.11 APE8-rot-in 303.21 APE67-dihe-in -53.0, -34.54 -57.92, -43.35 APE12-dist-in 12.8362 APE11-dist-in 11.987 APE10-dist-in 6.0501 APE9-dist-in 3.9447 None None None XRAY 2.0 0.164 0.193 A 301.0 299.0 0 32 32 0 [[205, 494]] 1.0 5fri TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 9F6XA P36897 200 500 503.0 A1IAZ:60401 Type1 Active DFGin 6.1352 13.3759 BLAminus -110.91, -175.59 63.64, 55.87 -85.09, 3.96 315.03, 1.12 -62.09, -27.8 in-in in 8.172 Saltbr-in 2.7303 HRD-in -72.7, -49.45 76.37, -0.74 in-in-in SNCiii in-in ActLoopNT-in 3.0083 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.61, -34.29 APE9-dihe-na -78.73, -165.12 APE8-dihe-in -74.89, 126.22 APE8-rot-in 295.38 APE67-dihe-in -52.17, -40.21 -62.21, -41.17 APE12-dist-in 13.4771 APE11-dist-in 12.2322 APE10-dist-in 6.1031 APE9-dist-in 3.6045 None None None XRAY 2.68 0.214 0.248 A 303.0 301.0 0 32 32 0 [[205, 494]] 1.0 9f6x TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 4X0MA P36897 200 501 503.0 3WA:60601 Type1 Active DFGin 6.2527 12.8838 BLAminus -128.27, -179.8 55.38, 57.51 -85.94, 12.49 298.0, 10.23 -63.66, -28.1 in-in in 7.3435 Saltbr-in 3.1528 HRD-in -62.49, -53.22 74.03, -11.67 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.83, 167.91 APE9-dihe-na 99.86, -179.25 APE8-dihe-in -77.31, 123.46 APE8-rot-in 305.82 APE67-dihe-in -54.73, -39.98 -54.51, -42.68 APE12-dist-in 11.6893 APE11-dist-in 11.8721 APE10-dist-in 6.2103 APE9-dist-in 3.8227 None None None XRAY 1.68 0.21 0.239 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x0m TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 4X2FA P36897 200 501 503.0 3WJ:60601 Type1 Active DFGin 6.1979 12.989 BLAminus -129.57, -169.63 49.35, 56.72 -81.87, 7.01 303.23, 9.49 -60.29, -24.32 in-in in 7.5569 Saltbr-in 2.9392 HRD-in -74.24, -48.95 76.58, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.9426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.03, 171.99 APE9-dihe-na 101.85, 179.14 APE8-dihe-in -82.12, 123.51 APE8-rot-in 300.96 APE67-dihe-in -58.79, -32.2 -58.45, -40.31 APE12-dist-in 11.8046 APE11-dist-in 11.9059 APE10-dist-in 6.1965 APE9-dist-in 3.807 None None None XRAY 1.49 0.165 0.191 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2f TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 4X2GA P36897 200 501 503.0 3WK:60601 Type1 Active DFGin 6.1606 12.9952 BLAminus -126.43, -164.75 48.26, 54.97 -83.24, 5.58 306.41, 9.37 -59.31, -23.57 in-in in 7.5596 Saltbr-in 3.0628 HRD-in -73.4, -50.72 76.5, -5.82 in-in-in SNCiii in-in ActLoopNT-in 2.9053 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.4, 173.04 APE9-dihe-na 101.04, 176.44 APE8-dihe-in -79.69, 125.01 APE8-rot-in 303.47 APE67-dihe-in -59.43, -31.39 -61.05, -38.4 APE12-dist-in 11.8525 APE11-dist-in 11.9254 APE10-dist-in 6.2206 APE9-dist-in 3.7931 None None None XRAY 1.51 0.166 0.185 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2g TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 2WOTA P36897 200 500 503.0 ZZG:61500 Type1 Active DFGin 6.1003 13.0307 BLAminus -130.27, -169.46 60.16, 61.47 -92.46, 8.2 303.12, 6.85 -64.56, -24.36 in-in in 7.6632 Saltbr-in 3.0739 HRD-in -80.51, -53.82 76.92, 0.39 in-in-in SNCiii in-in ActLoopNT-in 2.9504 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.42, -22.62 APE9-dihe-na -94.01, -157.41 APE8-dihe-in -80.51, 121.5 APE8-rot-in 307.33 APE67-dihe-in -52.87, -38.64 -55.17, -43.39 APE12-dist-in 13.1307 APE11-dist-in 12.2875 APE10-dist-in 6.3377 APE9-dist-in 3.7701 None None None XRAY 1.85 0.181 0.221 A 306.0 301.0 0 32 32 0 [[205, 494]] 1.0 2wot TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 2WOUA P36897 200 496 503.0 ZZF:61500 Type1 Active DFGin 6.1243 13.0393 BLAminus -133.49, -169.53 51.05, 62.4 -92.04, 13.34 298.31, 178.69 -62.77, -27.98 in-in in 7.5857 Saltbr-in 2.7517 HRD-in -65.52, -56.03 81.95, -3.97 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.77, -22.31 APE9-dihe-na -79.77, -172.15 APE8-dihe-in -73.94, 125.36 APE8-rot-in 306.35 APE67-dihe-in -52.11, -29.79 -56.64, -45.19 APE12-dist-in 13.0776 APE11-dist-in 11.9354 APE10-dist-in 6.0414 APE9-dist-in 3.6288 None None None XRAY 2.3 0.229 0.302 A 306.0 297.0 0 32 32 0 [[205, 494]] 1.0 2wou TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 8YHLA P36897 200 501 503.0 A1D6I:60601 Type1 Active DFGin 6.0207 13.0482 BLAminus -124.89, -169.46 42.91, 75.25 -91.67, 10.82 300.67, 10.41 -67.27, -22.16 in-in in 7.6986 Saltbr-in 2.9646 HRD-in -79.41, -52.59 75.07, -1.34 in-in-in SNCiii in-in ActLoopNT-in 2.9317 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.3, 155.92 APE9-dihe-na 107.61, -172.07 APE8-dihe-in -88.21, 123.34 APE8-rot-in 304.18 APE67-dihe-in -56.11, -38.82 -61.94, -38.97 APE12-dist-in 13.3426 APE11-dist-in 12.5182 APE10-dist-in 6.3143 APE9-dist-in 3.8164 None None None XRAY 1.47 0.165 0.193 A 306.0 302.0 0 32 32 0 [[205, 494]] 1.0 8yhl TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5E8WA P36897 200 501 503.0 STU:60601 Type1 Active DFGin 6.2162 12.9909 BLAminus -115.91, -168.56 48.03, 66.8 -87.81, 6.99 303.66, 6.47 -53.89, -34.67 in-in in 7.5613 Saltbr-in 2.815 HRD-in -71.33, -51.46 73.08, -1.55 in-in-in SNCiii in-in ActLoopNT-in 2.9924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.36, -32.83 APE9-dihe-na -81.66, -157.24 APE8-dihe-in -82.54, 122.58 APE8-rot-in 299.35 APE67-dihe-in -53.78, -37.25 -53.32, -45.52 APE12-dist-in 13.0541 APE11-dist-in 12.4184 APE10-dist-in 6.2997 APE9-dist-in 3.7378 T204D None None XRAY 1.86 0.168 0.186 A 307.0 302.0 0 32 32 0 [[205, 494]] 1.0 5e8w TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5E8ZA P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 5.9379 12.7418 BLAminus -131.72, -172.47 57.21, 65.07 -93.0, 9.47 305.33, 7.41 -62.65, -21.83 in-in in 7.8695 Saltbr-in 2.9396 HRD-in -73.84, -51.69 76.4, -3.34 in-in-in SNCiii in-in ActLoopNT-in 2.9146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.19, -27.35 APE9-dihe-na -88.81, -157.37 APE8-dihe-in -81.17, 121.36 APE8-rot-in 303.09 APE67-dihe-in -55.51, -33.19 -54.0, -44.23 APE12-dist-in 13.1171 APE11-dist-in 12.1808 APE10-dist-in 6.1394 APE9-dist-in 3.7752 T204D None None XRAY 1.51 0.183 0.207 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e8z TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5QIKA P36897 200 499 503.0 J2M:60601 Type1 Active DFGin 6.1343 12.8218 BLAminus -129.19, -176.86 54.93, 67.17 -89.45, 12.6 307.08, 5.45 -57.51, -28.59 in-in in 8.0373 Saltbr-in 2.8535 HRD-in -74.13, -49.19 76.47, -1.78 in-in-in SNCiii in-in ActLoopNT-in 2.9436 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.77, -28.33 APE9-dihe-na -83.38, -158.15 APE8-dihe-in -83.03, 121.9 APE8-rot-in 297.41 APE67-dihe-in -57.88, -31.82 -55.17, -43.49 APE12-dist-in 13.2243 APE11-dist-in 12.4103 APE10-dist-in 6.3932 APE9-dist-in 3.8354 T204D None None XRAY 1.58 0.166 0.19 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qik TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5QILA P36897 200 499 503.0 J2V:60601 Type1 Active DFGin 6.1235 12.8928 BLAminus -133.55, -173.28 54.13, 68.92 -94.29, 10.19 306.15, 4.81 -59.56, -26.12 in-in in 7.7817 Saltbr-in 3.0119 HRD-in -72.26, -48.55 71.72, 0.05 in-in-in SNCiii in-in ActLoopNT-in 2.9767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.42, -32.81 APE9-dihe-na -79.5, -152.05 APE8-dihe-in -86.88, 119.67 APE8-rot-in 305.45 APE67-dihe-in -55.45, -33.57 -52.15, -44.93 APE12-dist-in 12.8387 APE11-dist-in 12.2774 APE10-dist-in 6.1526 APE9-dist-in 3.7916 T204D None None XRAY 1.98 0.171 0.21 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qil TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5QTZA P36897 200 499 503.0 QMY:60601 Type1 Active DFGin 6.1735 13.3501 BLAminus -138.39, -173.58 55.38, 56.92 -82.72, 7.96 301.94, 5.0 -56.41, -28.87 in-in in 8.1475 Saltbr-in 2.8985 HRD-in -70.33, -51.13 74.03, -4.37 in-in-in SNCiii in-in ActLoopNT-in 3.0249 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.52, -26.25 APE9-dihe-na -81.63, -163.74 APE8-dihe-in -76.85, 122.93 APE8-rot-in 300.9 APE67-dihe-in -53.47, -35.21 -52.57, -45.07 APE12-dist-in 12.9828 APE11-dist-in 12.1763 APE10-dist-in 6.1682 APE9-dist-in 3.6578 T204D None None XRAY 1.83 0.171 0.2 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qtz TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5QU0A P36897 200 502 503.0 QMV:60601 Type1 Active DFGin 6.2257 13.4933 BLAminus -131.41, -169.26 50.76, 57.03 -82.09, 5.13 306.24, 2.05 -53.78, -29.06 in-in in 7.858 Saltbr-in 2.9235 HRD-in -72.09, -52.96 76.9, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.9609 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -85.59, 161.83 APE9-dihe-na 106.22, 171.28 APE8-dihe-in -76.79, 124.94 APE8-rot-in 300.79 APE67-dihe-in -53.51, -36.09 -55.88, -43.03 APE12-dist-in 13.2806 APE11-dist-in 12.425 APE10-dist-in 6.2542 APE9-dist-in 3.6548 T204D None None XRAY 1.67 0.178 0.206 A 307.0 303.0 0 32 32 0 [[205, 494]] 1.0 5qu0 TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 2X7OA P36897 171 500 503.0 ZOP:600 Type1 Active DFGin 6.8319 13.7743 BLAminus -128.16, 169.92 59.52, 88.44 -108.37, 28.14 289.28, 149.08 -69.29, -30.37 in-in in 8.0878 Saltbr-in 3.5322 HRD-in -65.4, -40.58 69.2, -25.74 in-in-in SNCiii in-in ActLoopNT-in 3.0569 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 149.39 APE9-dihe-na 96.51, -171.18 APE8-dihe-in -74.29, 131.0 APE8-rot-in 315.1 APE67-dihe-in -64.94, -34.48 -61.98, -32.57 APE12-dist-in 11.8201 APE11-dist-in 11.797 APE10-dist-in 5.9727 APE9-dist-in 4.7389 None None None XRAY 3.7 0.267 0.273 A 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3FAAA P36897 171 500 503.0 55F:601 Type1 Active DFGin 5.9037 13.0472 BLAminus -165.74, 163.41 74.29, 54.12 -79.67, 24.05 317.06, 176.62 -56.68, -51.28 in-in in 8.0011 Saltbr-in 2.9364 HRD-in -45.11, -27.8 52.25, 11.68 in-in-in SNCiii in-in ActLoopNT-in 3.1109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, -171.19 APE9-dihe-na 80.03, 171.79 APE8-dihe-in -67.98, 121.11 APE8-rot-in 302.91 APE67-dihe-in -99.71, -73.49 -46.09, -5.99 APE12-dist-in 11.6243 APE11-dist-in 11.9673 APE10-dist-in 6.0149 APE9-dist-in 4.0613 None None None XRAY 3.35 0.228 0.271 A 342.0 328.0 2 32 30 2 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3FAAB P36897 171 501 503.0 55F:601 Type1 Active DFGin 6.0174 13.3063 BLAminus -136.45, -176.24 60.04, 54.86 -81.47, 12.98 307.95, 5.19 -52.57, -45.29 in-in in 8.0996 Saltbr-in 3.0373 HRD-in -75.89, -39.75 60.74, 14.93 in-in-in SNCiii in-in ActLoopNT-in 3.1146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.32, 175.24 APE9-dihe-na 101.52, 166.7 APE8-dihe-in -70.87, 127.35 APE8-rot-in 315.28 APE67-dihe-in -36.34, -44.33 -43.95, -69.54 APE12-dist-in 11.9404 APE11-dist-in 11.9996 APE10-dist-in 6.3733 APE9-dist-in 4.0844 None None None XRAY 3.35 0.228 0.271 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3FAAD P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.2595 13.1679 BLAminus -151.5, 176.63 62.94, 64.2 -90.99, 26.98 302.19, 4.38 -66.56, -19.34 in-in in 7.8095 Saltbr-in 2.7451 HRD-in -63.44, -55.82 78.14, 1.44 in-in-in SNCiii in-in ActLoopNT-in 2.8034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.86, 174.28 APE9-dihe-na 87.09, 173.14 APE8-dihe-in -66.87, 116.28 APE8-rot-in 325.42 APE67-dihe-in -60.47, -38.15 -48.63, -36.35 APE12-dist-in 11.7136 APE11-dist-in 11.8944 APE10-dist-in 6.3705 APE9-dist-in 4.2294 None None None XRAY 3.35 0.228 0.271 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3FAAE P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.355 13.3659 BLAminus -131.48, -168.05 37.37, 86.28 -107.7, 26.02 296.92, 176.17 -65.92, -19.56 in-in in 7.7814 Saltbr-in 3.0945 HRD-in -66.77, -57.93 79.95, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.13, 169.87 APE9-dihe-na 90.72, 172.5 APE8-dihe-in -64.72, 129.04 APE8-rot-in 310.98 APE67-dihe-in -56.46, -40.64 -59.57, -42.14 APE12-dist-in 11.9901 APE11-dist-in 12.0559 APE10-dist-in 6.5703 APE9-dist-in 3.9816 None None None XRAY 3.35 0.228 0.271 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 8YHFA P36897 201 498 503.0 A1D6I:601 Type1 Active DFGin 6.0367 13.1516 BLAminus -127.63, -168.18 39.33, 73.78 -89.91, 13.29 302.44, 7.93 -62.86, -27.56 in-in in 7.7993 Saltbr-in 3.0294 HRD-in -79.9, -54.99 79.42, -3.09 in-in-in SNCiii in-in ActLoopNT-in 2.9537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.79, -23.11 APE9-dihe-na -96.35, -152.57 APE8-dihe-in -84.18, 124.71 APE8-rot-in 302.64 APE67-dihe-in -56.72, -32.39 -61.45, -41.11 APE12-dist-in 13.1782 APE11-dist-in 12.22 APE10-dist-in 6.2179 APE9-dist-in 3.8345 None None None XRAY 1.4 0.167 0.192 A 343.0 298.0 0 32 32 0 [[205, 494]] 1.0 8yhf TKL_TGFBR1_HUMAN TKL 5e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 4X2JA P36897 200 501 503.0 3WN:60601 Type1.5_Back Active DFGin 6.2455 13.0815 BLAminus -129.47, -176.48 54.06, 62.42 -89.1, 7.12 300.54, 6.95 -58.75, -23.34 in-in in 7.5948 Saltbr-in 2.782 HRD-in -70.93, -49.34 73.15, -2.13 in-in-in SNCiii in-in ActLoopNT-in 2.9177 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.13, 172.46 APE9-dihe-na 95.45, -178.89 APE8-dihe-in -79.7, 121.22 APE8-rot-in 304.99 APE67-dihe-in -57.38, -35.27 -55.84, -42.14 APE12-dist-in 11.7897 APE11-dist-in 11.8977 APE10-dist-in 6.1985 APE9-dist-in 3.7642 None None None XRAY 1.69 0.167 0.184 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2j TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 4X2KA P36897 200 501 503.0 3WO:60601 Type1.5_Back Active DFGin 6.2455 13.0815 BLAminus -129.47, -176.48 54.06, 62.42 -89.1, 7.12 300.54, 6.95 -58.75, -23.34 in-in in 7.5948 Saltbr-in 2.782 HRD-in -70.93, -49.34 73.15, -2.13 in-in-in SNCiii in-in ActLoopNT-in 2.9177 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.13, 172.46 APE9-dihe-na 95.45, -178.89 APE8-dihe-in -79.7, 121.22 APE8-rot-in 304.99 APE67-dihe-in -57.38, -35.27 -55.84, -42.14 APE12-dist-in 11.7897 APE11-dist-in 11.8977 APE10-dist-in 6.1985 APE9-dist-in 3.7642 None None None XRAY 1.69 0.167 0.184 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2k TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 5QIMA P36897 200 501 503.0 J2Y:60601 Type1.5_Back Active DFGin 6.3236 13.3216 BLAminus -128.33, -166.59 51.25, 57.82 -86.79, 6.35 301.95, 6.09 -60.92, -25.47 in-in in 7.8472 Saltbr-in 2.81 HRD-in -73.31, -54.57 78.67, -3.84 in-in-in SNCiii in-in ActLoopNT-in 2.9307 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.1, -24.0 APE9-dihe-na -84.65, -159.21 APE8-dihe-in -83.03, 124.26 APE8-rot-in 298.64 APE67-dihe-in -57.08, -33.68 -53.72, -43.01 APE12-dist-in 13.141 APE11-dist-in 12.3244 APE10-dist-in 6.2586 APE9-dist-in 3.636 None None None XRAY 1.75 0.169 0.188 A 306.0 302.0 0 32 32 0 [[205, 494]] 1.0 5qim TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 6B8YA P36897 200 502 503.0 D0A:60601 Type1.5_Back Active DFGin 6.0545 13.0759 BLAminus -131.41, -174.19 61.19, 66.23 -95.1, 10.56 300.15, 7.66 -60.38, -25.6 in-in in 7.7706 Saltbr-in 2.9079 HRD-in -74.58, -53.37 74.48, -1.06 in-in-in SNCiii in-in ActLoopNT-in 2.9591 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.69, -30.19 APE9-dihe-na -79.71, -163.36 APE8-dihe-in -78.33, 124.12 APE8-rot-in 302.16 APE67-dihe-in -55.15, -33.95 -56.38, -43.01 APE12-dist-in 12.8956 APE11-dist-in 12.272 APE10-dist-in 6.1925 APE9-dist-in 3.665 T204D None None XRAY 1.65 0.18 0.208 A 307.0 303.0 0 32 32 0 [[205, 494]] 1.0 6b8y TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 2X7OC P36897 171 500 503.0 ZOP:600 Type1.5_Back Active DFGin 6.8533 13.7407 BLAminus -128.05, 170.08 59.35, 88.53 -108.53, 28.35 289.5, 149.12 -69.05, -31.39 in-in in 8.0731 Saltbr-in 3.511 HRD-in -65.39, -40.6 69.36, -25.98 in-in-in SNCiii in-in ActLoopNT-in 3.0597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.94, 148.96 APE9-dihe-na 97.31, -171.76 APE8-dihe-in -74.42, 131.23 APE8-rot-in 314.85 APE67-dihe-in -65.62, -33.63 -61.56, -33.26 APE12-dist-in 11.7848 APE11-dist-in 11.7925 APE10-dist-in 5.9672 APE9-dist-in 4.7319 None None None XRAY 3.7 0.267 0.273 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 2X7OD P36897 171 500 503.0 ZOP:600 Type1.5_Back Active DFGin 6.8515 13.7705 BLAminus -128.04, 169.94 59.4, 88.47 -108.43, 28.21 289.11, 149.16 -69.32, -30.88 in-in in 8.0909 Saltbr-in 3.5347 HRD-in -65.64, -40.65 69.2, -26.08 in-in-in SNCiii in-in ActLoopNT-in 3.0568 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.87, 149.08 APE9-dihe-na 96.88, -171.59 APE8-dihe-in -74.3, 131.16 APE8-rot-in 314.89 APE67-dihe-in -64.63, -35.86 -61.66, -32.82 APE12-dist-in 11.7959 APE11-dist-in 11.8009 APE10-dist-in 5.9723 APE9-dist-in 4.735 None None None XRAY 3.7 0.267 0.273 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 2X7OE P36897 171 500 503.0 ZOP:600 Type1.5_Back Active DFGin 6.8561 13.7287 BLAminus -128.08, 169.89 59.79, 88.24 -108.3, 28.24 289.35, 149.2 -69.25, -30.86 in-in in 8.09 Saltbr-in 3.5516 HRD-in -65.48, -40.48 69.3, -25.97 in-in-in SNCiii in-in ActLoopNT-in 3.0589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.31, 151.21 APE9-dihe-na 97.11, -171.6 APE8-dihe-in -74.4, 131.12 APE8-rot-in 315.09 APE67-dihe-in -65.13, -34.5 -61.63, -32.52 APE12-dist-in 11.7792 APE11-dist-in 11.735 APE10-dist-in 5.956 APE9-dist-in 4.7312 None None None XRAY 3.7 0.267 0.273 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3KCFA P36897 171 500 503.0 JZO:1 Type1.5_Back Active DFGin 6.1932 12.9048 BLAminus -150.7, 165.18 67.92, 79.43 -90.06, 14.08 309.25, 11.69 -44.14, -39.87 in-in in 8.1956 Saltbr-in 2.8368 HRD-in -56.75, -49.06 70.7, 0.3 in-in-in SNCiii in-in ActLoopNT-in 2.9397 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.99, 164.53 APE9-dihe-na 104.66, 167.11 APE8-dihe-in -69.97, 124.0 APE8-rot-in 297.54 APE67-dihe-in -37.23, -57.4 -40.07, -69.34 APE12-dist-in 11.4628 APE11-dist-in 12.1707 APE10-dist-in 6.1624 APE9-dist-in 3.7623 None None None XRAY 2.8 0.237 0.278 A 342.0 328.0 2 32 30 2 [[205, 494]] 1.0 3kcf TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3KCFB P36897 171 501 503.0 JZO:2 Type1.5_Back Active DFGin 6.0248 12.6274 BLAminus -135.28, -176.57 58.41, 88.07 -103.95, 28.48 315.03, 7.91 -62.87, -35.81 in-in in 8.1446 Saltbr-in 2.6009 HRD-in -81.18, -54.27 77.68, -8.36 in-in-in SNCiii in-in ActLoopNT-in 2.9703 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.7, -176.11 APE9-dihe-na 95.21, 172.61 APE8-dihe-in -76.23, 133.32 APE8-rot-in 308.48 APE67-dihe-in -45.62, -25.89 -46.72, -68.47 APE12-dist-in 11.5191 APE11-dist-in 11.4129 APE10-dist-in 5.9541 APE9-dist-in 3.7322 None None None XRAY 2.8 0.237 0.278 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 3kcf TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3KCFC P36897 171 500 503.0 JZO:3 Type1.5_Back Active DFGin 6.6922 12.959 BLAminus -135.28, 165.04 69.33, 88.35 -106.61, 31.51 302.0, 1.76 -58.82, -55.68 in-in in 8.0361 Saltbr-in 2.3791 HRD-in -81.96, -30.19 61.27, -12.68 in-in-in SNCiii in-in ActLoopNT-in 2.8972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.43, -160.74 APE9-dihe-na 83.32, -178.05 APE8-dihe-in -94.01, 131.52 APE8-rot-in 317.12 APE67-dihe-in -41.44, -18.99 -53.51, -67.7 APE12-dist-in 10.7421 APE11-dist-in 11.8422 APE10-dist-in 6.2245 APE9-dist-in 3.8557 None None None XRAY 2.8 0.237 0.278 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3kcf TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3KCFD P36897 171 500 503.0 JZO:4 Type1.5_Back Active DFGin 6.8886 12.9989 BLAminus -135.85, -173.78 57.12, 75.33 -93.52, 22.15 298.91, 178.96 -63.23, -14.31 in-in in 8.2643 Saltbr-in 2.8937 HRD-in -62.47, -52.01 74.47, -2.58 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.66, 172.34 APE9-dihe-na 99.39, 173.59 APE8-dihe-in -80.33, 105.05 APE8-rot-in 316.25 APE67-dihe-in -46.61, -41.72 -34.28, -49.6 APE12-dist-in 12.0425 APE11-dist-in 12.0502 APE10-dist-in 6.3267 APE9-dist-in 4.0441 None None None XRAY 2.8 0.237 0.278 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3kcf TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3KCFE P36897 171 500 503.0 JZO:5 Type1.5_Back Active DFGin 6.468 12.9815 BLAminus -143.17, -179.95 57.87, 88.27 -108.02, 21.93 307.67, 3.89 -69.37, -7.25 in-in in 8.0283 Saltbr-in 2.8557 HRD-in -68.17, -50.18 73.66, 3.11 in-in-in SNCiii in-in ActLoopNT-in 2.9023 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.74, 177.4 APE9-dihe-na 104.24, -175.74 APE8-dihe-in -89.11, 123.84 APE8-rot-in 292.33 APE67-dihe-in -50.81, -36.21 -50.11, -48.46 APE12-dist-in 9.931 APE11-dist-in 12.0011 APE10-dist-in 6.2167 APE9-dist-in 3.7965 None None None XRAY 2.8 0.237 0.278 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3kcf TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1B6CB P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.8508 13.3938 BLAminus -130.85, -177.18 52.69, 80.31 -95.42, 25.6 300.29, 176.12 -64.72, -15.76 in-out in 8.6028 Saltbr-out 4.1145 HRD-in -69.56, -62.44 85.43, -5.19 out-in-out SNCoio in-out ActLoopNT-in 2.9563 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.23, 170.19 APE9-dihe-na -45.35, 160.71 APE8-dihe-in -68.99, 127.88 APE8-rot-in 301.39 APE67-dihe-in -71.24, -15.17 -60.4, -35.84 APE12-dist-in 11.4529 APE11-dist-out 7.3149 APE10-dist-out 8.4482 APE9-dist-in 3.7304 None None None XRAY 2.6 0.249 0.269 B 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1B6CD P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.9628 13.3173 BLAminus -130.99, -177.26 52.75, 80.27 -95.41, 25.6 300.53, 176.04 -64.6, -15.85 in-out in 8.6001 Saltbr-out 4.1147 HRD-in -69.77, -62.44 85.53, -5.06 out-in-out SNCoio in-out ActLoopNT-in 2.9575 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.35, 170.01 APE9-dihe-na -45.12, 160.61 APE8-dihe-in -69.1, 128.03 APE8-rot-in 301.09 APE67-dihe-in -71.13, -15.35 -60.35, -36.04 APE12-dist-in 11.4533 APE11-dist-out 7.3138 APE10-dist-out 8.445 APE9-dist-in 3.7254 None None None XRAY 2.6 0.249 0.269 D 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1B6CF P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.9976 13.8141 BLAminus -130.93, -177.22 52.78, 80.13 -95.35, 25.63 300.41, 176.19 -64.73, -15.73 in-out in 8.6018 Saltbr-out 4.1142 HRD-in -69.45, -62.52 85.59, -5.04 out-in-out SNCoio in-out ActLoopNT-in 2.9568 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.38, 170.18 APE9-dihe-na -45.27, 160.69 APE8-dihe-in -69.12, 128.05 APE8-rot-in 301.08 APE67-dihe-in -71.24, -15.27 -60.51, -35.82 APE12-dist-in 11.4545 APE11-dist-out 7.3138 APE10-dist-out 8.4448 APE9-dist-in 3.7272 None None None XRAY 2.6 0.249 0.269 F 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1B6CH P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.933 13.3732 BLAminus -131.03, -177.2 52.83, 80.24 -95.22, 25.39 300.35, 176.04 -64.71, -15.81 in-out in 8.6014 Saltbr-out 4.1131 HRD-in -69.67, -62.6 85.56, -5.13 out-in-out SNCoio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.24, 170.15 APE9-dihe-na -45.32, 160.68 APE8-dihe-in -69.01, 127.87 APE8-rot-in 301.38 APE67-dihe-in -71.25, -15.25 -60.38, -35.9 APE12-dist-in 11.451 APE11-dist-out 7.3115 APE10-dist-out 8.4461 APE9-dist-in 3.7295 None None None XRAY 2.6 0.249 0.269 H 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1RW8A P36897 200 500 503.0 580:501 Type1 Inactive DFGin 6.0226 12.8451 BLAminus -123.87, -176.48 52.01, 78.57 -101.69, 16.55 307.13, 6.03 -62.1, -24.92 in-in in 7.8414 Saltbr-in 3.4673 HRD-in -69.23, -61.02 80.12, 4.14 in-in-out SNCiio in-out ActLoopNT-in 2.9024 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -83.25, -151.65 APE9-dihe-na -88.81, -163.17 APE8-dihe-in -80.66, 118.18 APE8-rot-in 309.35 APE67-dihe-in -55.07, -38.39 -52.69, -43.2 APE12-dist-in 11.4864 APE11-dist-in 8.8535 APE10-dist-out 8.6198 APE9-dist-in 4.1068 None None None XRAY 2.4 0.26 0.291 A 301.0 301.0 0 32 32 0 [[205, 494]] 1.0 1rw8 TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1PY5A P36897 200 500 503.0 PY1:700 Type1 Inactive DFGin 6.3254 13.0957 BLAminus -139.22, -176.23 51.49, 62.68 -91.32, 17.81 306.9, 168.43 -57.65, -31.73 in-in in 7.8314 Saltbr-in 2.8966 HRD-in -74.07, -48.58 75.5, -7.56 in-in-out SNCiio in-out ActLoopNT-in 2.8618 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.55, -147.04 APE9-dihe-na -97.21, -166.02 APE8-dihe-in -77.65, 124.21 APE8-rot-in 307.07 APE67-dihe-in -64.31, -27.94 -63.63, -30.26 APE12-dist-in 11.444 APE11-dist-in 8.66 APE10-dist-out 8.5722 APE9-dist-in 4.1185 None None None XRAY 2.3 0.26 0.292 A 326.0 301.0 0 32 32 0 [[205, 494]] 1.0 1py5 TKL_TGFBR1_HUMAN TKL 4.1e-85 291.4 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 2X7OB P36897 171 500 503.0 ZOP:600 Type1 Inactive DFGin 6.8577 13.7456 BLAminus -128.22, 169.83 59.7, 88.26 -108.23, 28.26 289.27, 149.16 -69.33, -30.83 in-out in 8.1184 Saltbr-out 3.8328 HRD-in -65.55, -40.47 69.31, -25.99 out-in-in SNCoii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.06, 149.04 APE9-dihe-na 97.27, -171.94 APE8-dihe-in -74.39, 131.11 APE8-rot-in 314.97 APE67-dihe-in -65.1, -35.09 -61.66, -32.49 APE12-dist-in 11.7932 APE11-dist-in 11.7932 APE10-dist-in 5.9674 APE9-dist-in 4.7272 None None None XRAY 3.7 0.267 0.273 B 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3FAAC P36897 171 500 503.0 55F:601 Type1 Inactive DFGin 6.142 13.1414 BLAminus -126.27, 176.42 50.71, 78.49 -102.58, 30.06 320.3, 19.34 -66.31, -17.95 in-in in 7.9903 Saltbr-in 2.6623 HRD-in -67.56, -21.99 46.1, 19.37 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -120.66, 131.05 APE9-dihe-na 148.7, 175.0 APE8-dihe-in -102.93, 87.73 APE8-rot-in 305.5 APE67-dihe-out -28.83, -55.82 5.18, -84.04 APE12-dist-in 11.4809 APE11-dist-in 12.1489 APE10-dist-in 6.2467 APE9-dist-in 4.208 None None None XRAY 3.35 0.228 0.271 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 1VJYA P36897 201 503 503.0 460:999 Type1 None DFGin 6.0948 12.7955 BLAminus -131.96, -168.3 46.73, 72.17 -95.27, 7.02 307.89, 4.49 -49.86, -32.3 in-in in 7.7255 Saltbr-in 2.7526 HRD-in -71.95, -49.94 73.94, 4.16 in-in-none SNCiin in-none ActLoopNT-in 2.8478 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -108.72, 178.34 APE9-dihe-na 100.08, -177.16 APE8-dihe-in -88.48, 114.15 APE8-rot-in 304.07 APE67-dihe-in -56.76, -36.75 -44.55, -45.61 APE12-dist-none 999.0 APE11-dist-in 11.5573 APE10-dist-in 6.5127 APE9-dist-in 3.8649 None None None XRAY 2.0 0.223 0.275 A 303.0 299.0 4 32 28 4 [[205, 494]] 1.0 1vjy TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3GXLA P36897 201 498 503.0 QIG:60999 Type1 None DFGin 5.986 13.1617 BLAminus -117.01, -170.6 33.6, 86.88 -102.63, 15.85 311.96, 176.51 -62.1, -23.52 in-in in 8.2229 Saltbr-in 2.9297 HRD-in -71.35, -53.37 77.01, 1.76 in-in-none SNCiin in-none ActLoopNT-in 2.9585 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -62.74, 167.86 APE9-dihe-na 117.67, 172.21 APE8-dihe-in -83.62, 118.05 APE8-rot-in 304.44 APE67-dihe-in -50.23, -35.35 -45.35, -55.49 APE12-dist-none 999.0 APE11-dist-in 12.1584 APE10-dist-in 6.7392 APE9-dist-in 4.1731 None None None XRAY 1.8 0.228 0.263 A 303.0 285.0 13 32 27 5 [[205, 494]] 1.0 3gxl TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3HMMA P36897 201 498 503.0 855:60857 Type1 None DFGin 6.1186 13.0492 BLAminus -127.07, -168.91 53.99, 65.82 -94.96, 13.15 305.68, 3.69 -60.53, -23.27 in-in in 8.024 Saltbr-in 2.8121 HRD-in -74.05, -51.32 76.01, -1.97 in-in-none SNCiin in-none ActLoopNT-in 2.9341 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.63 APE8-dihe-in -79.78, 120.6 APE8-rot-in 300.84 APE67-dihe-in -55.11, -37.41 -48.22, -47.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.917 None None None XRAY 1.7 0.223 0.241 A 303.0 293.0 5 32 27 5 [[205, 494]] 1.0 3hmm TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 9J9DA P36897 202 502 503.0 A1L30:701 Type1 None DFGin 5.9671 12.4549 BLAminus -128.65, -173.5 51.95, 67.83 -91.44, 10.62 307.73, 2.77 -64.11, -26.42 in-in in 8.0195 Saltbr-in 2.8069 HRD-in -76.64, -51.57 79.18, -0.61 in-in-none SNCiin in-none ActLoopNT-in 2.9198 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -92.35, -34.47 APE9-dihe-na -89.02, -159.15 APE8-dihe-in -77.18, 122.97 APE8-rot-in 307.18 APE67-dihe-in -57.12, -34.57 -60.97, -41.48 APE12-dist-none 999.0 APE11-dist-in 12.1448 APE10-dist-in 6.1626 APE9-dist-in 4.0669 None None None XRAY 1.337 0.191 0.209 A 306.0 296.0 5 32 30 2 [[205, 494]] 1.0 9j9d TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 3TZMA P36897 200 496 503.0 085:1 Type1 None DFGin 6.0654 13.1056 BLAminus -122.58, -169.81 59.22, 59.29 -91.38, 11.48 304.6, 5.41 -64.05, -23.93 in-in in 7.9635 Saltbr-in 2.8335 HRD-in -81.31, -50.79 80.1, -5.96 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -87.36, 160.54 APE9-dihe-na 102.22, -177.2 APE8-dihe-in -87.37, 126.2 APE8-rot-in 298.62 APE67-dihe-in -59.36, -31.96 -58.47, -41.28 APE12-dist-none 999.0 APE11-dist-in 12.2382 APE10-dist-in 6.1835 APE9-dist-in 3.825 None None None XRAY 1.7 0.172 0.205 A 309.0 295.0 2 32 30 2 [[205, 494]] 1.0 3tzm TKL_TGFBR1_HUMAN TKL 3.4e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1

TKL_TGFBR1 (TGF-beta receptor type-1)

Total number of chains: 59
Active chains: 46
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 59 100.0% AF-P36897-K1A

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TGFBR1 TGFR1_HUMAN 5E8UA P36897 200 502 503.0 No_ligand No_ligand Active DFGin 7.2504 14.2389 BLAminus -134.62, -172.63 56.13, 81.95 -101.29, 16.47 292.48, 105.22 -57.91, -29.22 in-in in 7.8868 Saltbr-in 2.9459 HRD-in -72.05, -48.87 69.51, 7.62 in-in-in SNCiii in-in ActLoopNT-in 2.9688 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.25, 153.37 APE9-dihe-na 113.03, -170.78 APE8-dihe-in -89.61, 116.01 APE8-rot-in 305.95 APE67-dihe-in -56.91, -33.28 -47.65, -46.01 APE12-dist-in 13.1407 APE11-dist-in 12.5219 APE10-dist-in 6.4804 APE9-dist-in 3.9582 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 2.03 0.181 0.223 A 307.0 303.0 0 32 32 0 [[205, 494]] 1.0 5e8u Homo sapiens TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 4X2NA P36897 200 501 503.0 No_ligand No_ligand Active DFGin 6.1503 13.2 BLAminus -127.58, -171.48 51.56, 55.64 -81.72, 7.99 306.47, 9.87 -57.69, -30.68 in-in in 7.7458 Saltbr-in 3.1369 HRD-in -73.45, -50.82 74.64, -6.69 in-in-in SNCiii in-in ActLoopNT-in 2.9883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.64, 175.91 APE9-dihe-na 96.93, 176.28 APE8-dihe-in -81.13, 124.7 APE8-rot-in 305.67 APE67-dihe-in -55.99, -35.77 -56.51, -42.26 APE12-dist-in 11.7879 APE11-dist-in 11.8763 APE10-dist-in 6.1938 APE9-dist-in 3.7123 None None None XRAY 1.8 0.163 0.201 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2n Homo sapiens TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5E8SA P36897 200 498 503.0 No_ligand No_ligand Active DFGin 6.227 13.3447 BLAminus -130.71, -170.38 50.26, 56.29 -81.51, 7.19 302.58, 10.42 -59.69, -25.71 in-in in 7.7497 Saltbr-in 3.0983 HRD-in -75.18, -50.46 75.3, -6.11 in-in-in SNCiii in-in ActLoopNT-in 2.9421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.12, 158.63 APE9-dihe-na 109.47, 177.89 APE8-dihe-in -83.28, 125.6 APE8-rot-in 301.61 APE67-dihe-in -57.6, -32.67 -59.04, -39.92 APE12-dist-in 13.3842 APE11-dist-in 12.4174 APE10-dist-in 6.3031 APE9-dist-in 3.6774 None None None XRAY 1.45 0.172 0.188 A 306.0 299.0 0 32 32 0 [[205, 494]] 1.0 5e8s Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN AF-P36897-K1A P36897 197 502 503.0 No_ligand No_ligand Active DFGin 6.0972 12.6974 BLAminus -127.47, -177.39 59.98, 50.67 -75.64, 9.99 303.25, 0.83 -67.03, -14.65 in-in in 7.7504 Saltbr-in 2.6308 HRD-in -79.18, -43.89 66.79, -8.16 in-in-in SNCiii in-in ActLoopNT-in 3.0147 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.74, 159.13 APE9-dihe-na 99.19, -175.01 APE8-dihe-in -81.52, 117.2 APE8-rot-in 304.32 APE67-dihe-in -58.11, -28.29 -49.21, -42.7 APE12-dist-in 13.0338 APE11-dist-in 12.4755 APE10-dist-in 6.3484 APE9-dist-in 3.7811 None None None AF2 -1.0 1.0 1.0 A 306.0 306.0 0 32 32 0 [[205, 494]] 1.0 AF-P36897-K1 Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN AF-P36897-K3A P36897 197 502 503.0 No_ligand No_ligand Active DFGin 6.3884 12.8818 BLAminus -127.89, -179.35 58.97, 55.86 -76.18, 6.96 301.47, 0.09 -63.41, -19.74 in-in in 8.0954 Saltbr-in 2.6745 HRD-in -77.05, -40.27 65.4, -16.45 in-in-in SNCiii in-in ActLoopNT-in 2.8499 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.36, 158.96 APE9-dihe-na 107.71, -175.1 APE8-dihe-in -94.3, 114.61 APE8-rot-in 303.53 APE67-dihe-in -61.67, -24.01 -41.02, -46.98 APE12-dist-in 11.2123 APE11-dist-in 11.8142 APE10-dist-in 5.9249 APE9-dist-in 3.7002 None None None AF2 -1.0 1.0 1.0 A 306.0 306.0 0 32 32 0 [[205, 494]] 1.0 AF-P36897-K3 Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5E8TA P36897 200 499 503.0 No_ligand No_ligand Active DFGin 6.1295 13.1171 BLAminus -129.7, -170.36 54.3, 58.56 -85.47, 9.03 309.14, 5.15 -56.74, -27.28 in-in in 7.8399 Saltbr-in 2.9399 HRD-in -72.25, -51.54 76.95, -4.64 in-in-in SNCiii in-in ActLoopNT-in 2.9687 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -78.56, -31.05 APE9-dihe-na -81.1, -159.38 APE8-dihe-in -84.33, 122.67 APE8-rot-in 299.0 APE67-dihe-in -55.04, -35.69 -53.58, -44.7 APE12-dist-in 13.0667 APE11-dist-in 12.2817 APE10-dist-in 6.2375 APE9-dist-in 3.7905 T204D None None XRAY 1.7 0.17 0.19 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e8t Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1IASA P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.7211 12.7225 BLAminus -151.41, 164.95 71.98, 88.97 -106.86, 22.49 311.89, 1.41 -60.78, -26.26 in-in in 8.2398 Saltbr-in 2.7897 HRD-in -63.37, -49.76 71.64, 8.78 in-in-in SNCiii in-in ActLoopNT-in 2.9738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.42, 172.85 APE9-dihe-na 97.41, 166.83 APE8-dihe-in -62.29, 121.18 APE8-rot-in 307.67 APE67-dihe-in -45.67, -30.78 -49.33, -54.47 APE12-dist-in 11.4524 APE11-dist-in 11.6294 APE10-dist-in 6.1724 APE9-dist-in 4.1313 None None None XRAY 2.9 0.255 0.284 A 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1IASB P36897 171 501 503.0 No_ligand No_ligand Active DFGin 6.6521 12.7075 BLAminus -150.79, 165.66 71.53, 88.91 -106.55, 22.01 312.14, 1.23 -60.97, -25.51 in-in in 8.2406 Saltbr-in 2.7993 HRD-in -64.38, -48.85 71.21, 7.9 in-in-in SNCiii in-in ActLoopNT-in 3.0054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.79, 173.68 APE9-dihe-na 99.72, 167.49 APE8-dihe-in -63.26, 121.22 APE8-rot-in 308.35 APE67-dihe-in -44.49, -32.42 -49.46, -55.33 APE12-dist-in 10.321 APE11-dist-in 11.6277 APE10-dist-in 6.2406 APE9-dist-in 4.0495 None None None XRAY 2.9 0.255 0.284 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 1ias Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1IASC P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.5902 12.7106 BLAminus -150.31, 164.7 71.4, 89.07 -106.94, 23.22 312.6, 1.77 -61.3, -25.67 in-in in 8.1971 Saltbr-in 2.7993 HRD-in -63.0, -50.37 71.83, 9.79 in-in-in SNCiii in-in ActLoopNT-in 3.0126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.75, 170.21 APE9-dihe-na 100.55, 167.25 APE8-dihe-in -63.65, 121.53 APE8-rot-in 308.64 APE67-dihe-in -44.33, -30.7 -49.24, -56.44 APE12-dist-in 11.3487 APE11-dist-in 11.7592 APE10-dist-in 6.2222 APE9-dist-in 4.1504 None None None XRAY 2.9 0.255 0.284 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1IASD P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.5942 12.7426 BLAminus -152.15, 165.79 70.83, 87.83 -105.27, 21.55 312.92, 0.98 -60.27, -25.54 in-in in 8.1886 Saltbr-in 2.7745 HRD-in -64.51, -48.18 71.39, 8.63 in-in-in SNCiii in-in ActLoopNT-in 2.9927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.69, 169.96 APE9-dihe-na 98.27, 166.26 APE8-dihe-in -61.5, 120.34 APE8-rot-in 308.37 APE67-dihe-in -44.16, -31.51 -48.36, -56.13 APE12-dist-in 10.7317 APE11-dist-in 11.7841 APE10-dist-in 6.1802 APE9-dist-in 4.0397 None None None XRAY 2.9 0.255 0.284 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1IASE P36897 171 500 503.0 No_ligand No_ligand Active DFGin 6.6847 12.7375 BLAminus -151.39, 165.15 70.82, 89.42 -106.94, 21.97 311.98, 2.05 -61.66, -24.41 in-in in 8.2265 Saltbr-in 2.8032 HRD-in -61.95, -50.33 72.19, 7.85 in-in-in SNCiii in-in ActLoopNT-in 3.0078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.31, 173.9 APE9-dihe-na 98.05, 167.39 APE8-dihe-in -64.1, 121.3 APE8-rot-in 308.19 APE67-dihe-in -45.93, -31.42 -49.14, -54.62 APE12-dist-in 11.6357 APE11-dist-in 11.5052 APE10-dist-in 6.1489 APE9-dist-in 4.002 None None None XRAY 2.9 0.255 0.284 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 1ias Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5E8XA P36897 200 503 503.0 STU:601 Type1 Active DFGin 7.4008 13.7714 BLAminus -132.02, 177.79 68.95, 84.86 -101.89, 20.89 298.69, 99.78 -60.9, -22.78 in-in in 7.6457 Saltbr-in 3.3162 HRD-in -78.83, -50.32 78.23, -2.28 in-in-in SNCiii in-in ActLoopNT-in 2.9268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.2, 171.93 APE9-dihe-na 104.3, 177.57 APE8-dihe-in -80.96, 119.4 APE8-rot-in 304.53 APE67-dihe-in -55.33, -34.35 -53.44, -41.29 APE12-dist-in 11.7091 APE11-dist-in 11.9272 APE10-dist-in 6.2584 APE9-dist-in 3.9463 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 1.45 0.191 0.21 A 307.0 304.0 0 32 32 0 [[205, 494]] 1.0 5e8x Homo sapiens TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5E90A P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 7.0329 13.9683 BLAminus -132.44, -170.95 59.07, 73.91 -100.08, 11.67 293.12, 109.78 -58.9, -27.5 in-in in 7.7319 Saltbr-in 2.8651 HRD-in -62.69, -55.46 77.29, -2.06 in-in-in SNCiii in-in ActLoopNT-in 2.8722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.74, -31.43 APE9-dihe-na -82.55, -164.68 APE8-dihe-in -74.68, 122.19 APE8-rot-in 303.81 APE67-dihe-in -54.67, -36.7 -55.17, -42.7 APE12-dist-in 12.5936 APE11-dist-in 11.8996 APE10-dist-in 5.8869 APE9-dist-in 3.841 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None None XRAY 2.05 0.178 0.218 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e90 Homo sapiens TKL_TGFBR1_HUMAN TKL 2.3e-85 292.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5USQA P36897 200 498 503.0 8LY:500 Type1 Active DFGin 6.294 13.4506 BLAminus -128.65, -178.48 58.74, 56.74 -84.73, 2.3 308.58, 3.38 -59.48, -22.95 in-in in 7.7524 Saltbr-in 3.1908 HRD-in -74.99, -53.41 77.78, -10.32 in-in-in SNCiii in-in ActLoopNT-in 2.9203 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.34, -32.16 APE9-dihe-na -75.45, -164.79 APE8-dihe-in -80.15, 126.14 APE8-rot-in 305.26 APE67-dihe-in -52.52, -34.72 -59.83, -43.81 APE12-dist-in 13.0242 APE11-dist-in 12.0079 APE10-dist-in 6.1582 APE9-dist-in 3.5574 None None None XRAY 2.55 0.182 0.231 A 299.0 299.0 0 32 32 0 [[205, 494]] 1.0 5usq Homo sapiens TKL_TGFBR1_HUMAN TKL 3e-85 291.9 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5FRIA P36897 200 498 503.0 ZUQ:61501 Type1 Active DFGin 5.986 12.349 BLAminus -129.47, -173.22 60.99, 71.38 -101.21, 12.39 307.22, 5.28 -67.89, -22.52 in-in in 7.7579 Saltbr-in 2.8572 HRD-in -78.14, -52.35 77.86, -1.93 in-in-in SNCiii in-in ActLoopNT-in 2.9265 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.89, -25.51 APE9-dihe-na -92.81, -153.48 APE8-dihe-in -86.34, 123.11 APE8-rot-in 303.21 APE67-dihe-in -53.0, -34.54 -57.92, -43.35 APE12-dist-in 12.8362 APE11-dist-in 11.987 APE10-dist-in 6.0501 APE9-dist-in 3.9447 None None None XRAY 2.0 0.164 0.193 A 301.0 299.0 0 32 32 0 [[205, 494]] 1.0 5fri Homo sapiens TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 9F6XA P36897 200 500 503.0 A1IAZ:60401 Type1 Active DFGin 6.1352 13.3759 BLAminus -110.91, -175.59 63.64, 55.87 -85.09, 3.96 315.03, 1.12 -62.09, -27.8 in-in in 8.172 Saltbr-in 2.7303 HRD-in -72.7, -49.45 76.37, -0.74 in-in-in SNCiii in-in ActLoopNT-in 3.0083 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.61, -34.29 APE9-dihe-na -78.73, -165.12 APE8-dihe-in -74.89, 126.22 APE8-rot-in 295.38 APE67-dihe-in -52.17, -40.21 -62.21, -41.17 APE12-dist-in 13.4771 APE11-dist-in 12.2322 APE10-dist-in 6.1031 APE9-dist-in 3.6045 None None None XRAY 2.68 0.214 0.248 A 303.0 301.0 0 32 32 0 [[205, 494]] 1.0 9f6x Homo sapiens TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 4X0MA P36897 200 501 503.0 3WA:60601 Type1 Active DFGin 6.2527 12.8838 BLAminus -128.27, -179.8 55.38, 57.51 -85.94, 12.49 298.0, 10.23 -63.66, -28.1 in-in in 7.3435 Saltbr-in 3.1528 HRD-in -62.49, -53.22 74.03, -11.67 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.83, 167.91 APE9-dihe-na 99.86, -179.25 APE8-dihe-in -77.31, 123.46 APE8-rot-in 305.82 APE67-dihe-in -54.73, -39.98 -54.51, -42.68 APE12-dist-in 11.6893 APE11-dist-in 11.8721 APE10-dist-in 6.2103 APE9-dist-in 3.8227 None None None XRAY 1.68 0.21 0.239 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x0m Homo sapiens TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 4X2FA P36897 200 501 503.0 3WJ:60601 Type1 Active DFGin 6.1979 12.989 BLAminus -129.57, -169.63 49.35, 56.72 -81.87, 7.01 303.23, 9.49 -60.29, -24.32 in-in in 7.5569 Saltbr-in 2.9392 HRD-in -74.24, -48.95 76.58, -5.05 in-in-in SNCiii in-in ActLoopNT-in 2.9426 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.03, 171.99 APE9-dihe-na 101.85, 179.14 APE8-dihe-in -82.12, 123.51 APE8-rot-in 300.96 APE67-dihe-in -58.79, -32.2 -58.45, -40.31 APE12-dist-in 11.8046 APE11-dist-in 11.9059 APE10-dist-in 6.1965 APE9-dist-in 3.807 None None None XRAY 1.49 0.165 0.191 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2f Homo sapiens TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 4X2GA P36897 200 501 503.0 3WK:60601 Type1 Active DFGin 6.1606 12.9952 BLAminus -126.43, -164.75 48.26, 54.97 -83.24, 5.58 306.41, 9.37 -59.31, -23.57 in-in in 7.5596 Saltbr-in 3.0628 HRD-in -73.4, -50.72 76.5, -5.82 in-in-in SNCiii in-in ActLoopNT-in 2.9053 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.4, 173.04 APE9-dihe-na 101.04, 176.44 APE8-dihe-in -79.69, 125.01 APE8-rot-in 303.47 APE67-dihe-in -59.43, -31.39 -61.05, -38.4 APE12-dist-in 11.8525 APE11-dist-in 11.9254 APE10-dist-in 6.2206 APE9-dist-in 3.7931 None None None XRAY 1.51 0.166 0.185 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2g Homo sapiens TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 2WOTA P36897 200 500 503.0 ZZG:61500 Type1 Active DFGin 6.1003 13.0307 BLAminus -130.27, -169.46 60.16, 61.47 -92.46, 8.2 303.12, 6.85 -64.56, -24.36 in-in in 7.6632 Saltbr-in 3.0739 HRD-in -80.51, -53.82 76.92, 0.39 in-in-in SNCiii in-in ActLoopNT-in 2.9504 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.42, -22.62 APE9-dihe-na -94.01, -157.41 APE8-dihe-in -80.51, 121.5 APE8-rot-in 307.33 APE67-dihe-in -52.87, -38.64 -55.17, -43.39 APE12-dist-in 13.1307 APE11-dist-in 12.2875 APE10-dist-in 6.3377 APE9-dist-in 3.7701 None None None XRAY 1.85 0.181 0.221 A 306.0 301.0 0 32 32 0 [[205, 494]] 1.0 2wot Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 2WOUA P36897 200 496 503.0 ZZF:61500 Type1 Active DFGin 6.1243 13.0393 BLAminus -133.49, -169.53 51.05, 62.4 -92.04, 13.34 298.31, 178.69 -62.77, -27.98 in-in in 7.5857 Saltbr-in 2.7517 HRD-in -65.52, -56.03 81.95, -3.97 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.77, -22.31 APE9-dihe-na -79.77, -172.15 APE8-dihe-in -73.94, 125.36 APE8-rot-in 306.35 APE67-dihe-in -52.11, -29.79 -56.64, -45.19 APE12-dist-in 13.0776 APE11-dist-in 11.9354 APE10-dist-in 6.0414 APE9-dist-in 3.6288 None None None XRAY 2.3 0.229 0.302 A 306.0 297.0 0 32 32 0 [[205, 494]] 1.0 2wou Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 8YHLA P36897 200 501 503.0 A1D6I:60601 Type1 Active DFGin 6.0207 13.0482 BLAminus -124.89, -169.46 42.91, 75.25 -91.67, 10.82 300.67, 10.41 -67.27, -22.16 in-in in 7.6986 Saltbr-in 2.9646 HRD-in -79.41, -52.59 75.07, -1.34 in-in-in SNCiii in-in ActLoopNT-in 2.9317 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -72.3, 155.92 APE9-dihe-na 107.61, -172.07 APE8-dihe-in -88.21, 123.34 APE8-rot-in 304.18 APE67-dihe-in -56.11, -38.82 -61.94, -38.97 APE12-dist-in 13.3426 APE11-dist-in 12.5182 APE10-dist-in 6.3143 APE9-dist-in 3.8164 None None None XRAY 1.47 0.165 0.193 A 306.0 302.0 0 32 32 0 [[205, 494]] 1.0 8yhl Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5E8WA P36897 200 501 503.0 STU:60601 Type1 Active DFGin 6.2162 12.9909 BLAminus -115.91, -168.56 48.03, 66.8 -87.81, 6.99 303.66, 6.47 -53.89, -34.67 in-in in 7.5613 Saltbr-in 2.815 HRD-in -71.33, -51.46 73.08, -1.55 in-in-in SNCiii in-in ActLoopNT-in 2.9924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -81.36, -32.83 APE9-dihe-na -81.66, -157.24 APE8-dihe-in -82.54, 122.58 APE8-rot-in 299.35 APE67-dihe-in -53.78, -37.25 -53.32, -45.52 APE12-dist-in 13.0541 APE11-dist-in 12.4184 APE10-dist-in 6.2997 APE9-dist-in 3.7378 T204D None None XRAY 1.86 0.168 0.186 A 307.0 302.0 0 32 32 0 [[205, 494]] 1.0 5e8w Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5E8ZA P36897 200 499 503.0 5L4:60601 Type1 Active DFGin 5.9379 12.7418 BLAminus -131.72, -172.47 57.21, 65.07 -93.0, 9.47 305.33, 7.41 -62.65, -21.83 in-in in 7.8695 Saltbr-in 2.9396 HRD-in -73.84, -51.69 76.4, -3.34 in-in-in SNCiii in-in ActLoopNT-in 2.9146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.19, -27.35 APE9-dihe-na -88.81, -157.37 APE8-dihe-in -81.17, 121.36 APE8-rot-in 303.09 APE67-dihe-in -55.51, -33.19 -54.0, -44.23 APE12-dist-in 13.1171 APE11-dist-in 12.1808 APE10-dist-in 6.1394 APE9-dist-in 3.7752 T204D None None XRAY 1.51 0.183 0.207 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5e8z Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5QIKA P36897 200 499 503.0 J2M:60601 Type1 Active DFGin 6.1343 12.8218 BLAminus -129.19, -176.86 54.93, 67.17 -89.45, 12.6 307.08, 5.45 -57.51, -28.59 in-in in 8.0373 Saltbr-in 2.8535 HRD-in -74.13, -49.19 76.47, -1.78 in-in-in SNCiii in-in ActLoopNT-in 2.9436 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -82.77, -28.33 APE9-dihe-na -83.38, -158.15 APE8-dihe-in -83.03, 121.9 APE8-rot-in 297.41 APE67-dihe-in -57.88, -31.82 -55.17, -43.49 APE12-dist-in 13.2243 APE11-dist-in 12.4103 APE10-dist-in 6.3932 APE9-dist-in 3.8354 T204D None None XRAY 1.58 0.166 0.19 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qik Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5QILA P36897 200 499 503.0 J2V:60601 Type1 Active DFGin 6.1235 12.8928 BLAminus -133.55, -173.28 54.13, 68.92 -94.29, 10.19 306.15, 4.81 -59.56, -26.12 in-in in 7.7817 Saltbr-in 3.0119 HRD-in -72.26, -48.55 71.72, 0.05 in-in-in SNCiii in-in ActLoopNT-in 2.9767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.42, -32.81 APE9-dihe-na -79.5, -152.05 APE8-dihe-in -86.88, 119.67 APE8-rot-in 305.45 APE67-dihe-in -55.45, -33.57 -52.15, -44.93 APE12-dist-in 12.8387 APE11-dist-in 12.2774 APE10-dist-in 6.1526 APE9-dist-in 3.7916 T204D None None XRAY 1.98 0.171 0.21 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qil Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5QTZA P36897 200 499 503.0 QMY:60601 Type1 Active DFGin 6.1735 13.3501 BLAminus -138.39, -173.58 55.38, 56.92 -82.72, 7.96 301.94, 5.0 -56.41, -28.87 in-in in 8.1475 Saltbr-in 2.8985 HRD-in -70.33, -51.13 74.03, -4.37 in-in-in SNCiii in-in ActLoopNT-in 3.0249 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.52, -26.25 APE9-dihe-na -81.63, -163.74 APE8-dihe-in -76.85, 122.93 APE8-rot-in 300.9 APE67-dihe-in -53.47, -35.21 -52.57, -45.07 APE12-dist-in 12.9828 APE11-dist-in 12.1763 APE10-dist-in 6.1682 APE9-dist-in 3.6578 T204D None None XRAY 1.83 0.171 0.2 A 307.0 300.0 0 32 32 0 [[205, 494]] 1.0 5qtz Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5QU0A P36897 200 502 503.0 QMV:60601 Type1 Active DFGin 6.2257 13.4933 BLAminus -131.41, -169.26 50.76, 57.03 -82.09, 5.13 306.24, 2.05 -53.78, -29.06 in-in in 7.858 Saltbr-in 2.9235 HRD-in -72.09, -52.96 76.9, -5.53 in-in-in SNCiii in-in ActLoopNT-in 2.9609 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -85.59, 161.83 APE9-dihe-na 106.22, 171.28 APE8-dihe-in -76.79, 124.94 APE8-rot-in 300.79 APE67-dihe-in -53.51, -36.09 -55.88, -43.03 APE12-dist-in 13.2806 APE11-dist-in 12.425 APE10-dist-in 6.2542 APE9-dist-in 3.6548 T204D None None XRAY 1.67 0.178 0.206 A 307.0 303.0 0 32 32 0 [[205, 494]] 1.0 5qu0 Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 2X7OA P36897 171 500 503.0 ZOP:600 Type1 Active DFGin 6.8319 13.7743 BLAminus -128.16, 169.92 59.52, 88.44 -108.37, 28.14 289.28, 149.08 -69.29, -30.37 in-in in 8.0878 Saltbr-in 3.5322 HRD-in -65.4, -40.58 69.2, -25.74 in-in-in SNCiii in-in ActLoopNT-in 3.0569 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 149.39 APE9-dihe-na 96.51, -171.18 APE8-dihe-in -74.29, 131.0 APE8-rot-in 315.1 APE67-dihe-in -64.94, -34.48 -61.98, -32.57 APE12-dist-in 11.8201 APE11-dist-in 11.797 APE10-dist-in 5.9727 APE9-dist-in 4.7389 None None None XRAY 3.7 0.267 0.273 A 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3FAAA P36897 171 500 503.0 55F:601 Type1 Active DFGin 5.9037 13.0472 BLAminus -165.74, 163.41 74.29, 54.12 -79.67, 24.05 317.06, 176.62 -56.68, -51.28 in-in in 8.0011 Saltbr-in 2.9364 HRD-in -45.11, -27.8 52.25, 11.68 in-in-in SNCiii in-in ActLoopNT-in 3.1109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, -171.19 APE9-dihe-na 80.03, 171.79 APE8-dihe-in -67.98, 121.11 APE8-rot-in 302.91 APE67-dihe-in -99.71, -73.49 -46.09, -5.99 APE12-dist-in 11.6243 APE11-dist-in 11.9673 APE10-dist-in 6.0149 APE9-dist-in 4.0613 None None None XRAY 3.35 0.228 0.271 A 342.0 328.0 2 32 30 2 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3FAAB P36897 171 501 503.0 55F:601 Type1 Active DFGin 6.0174 13.3063 BLAminus -136.45, -176.24 60.04, 54.86 -81.47, 12.98 307.95, 5.19 -52.57, -45.29 in-in in 8.0996 Saltbr-in 3.0373 HRD-in -75.89, -39.75 60.74, 14.93 in-in-in SNCiii in-in ActLoopNT-in 3.1146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.32, 175.24 APE9-dihe-na 101.52, 166.7 APE8-dihe-in -70.87, 127.35 APE8-rot-in 315.28 APE67-dihe-in -36.34, -44.33 -43.95, -69.54 APE12-dist-in 11.9404 APE11-dist-in 11.9996 APE10-dist-in 6.3733 APE9-dist-in 4.0844 None None None XRAY 3.35 0.228 0.271 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3FAAD P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.2595 13.1679 BLAminus -151.5, 176.63 62.94, 64.2 -90.99, 26.98 302.19, 4.38 -66.56, -19.34 in-in in 7.8095 Saltbr-in 2.7451 HRD-in -63.44, -55.82 78.14, 1.44 in-in-in SNCiii in-in ActLoopNT-in 2.8034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.86, 174.28 APE9-dihe-na 87.09, 173.14 APE8-dihe-in -66.87, 116.28 APE8-rot-in 325.42 APE67-dihe-in -60.47, -38.15 -48.63, -36.35 APE12-dist-in 11.7136 APE11-dist-in 11.8944 APE10-dist-in 6.3705 APE9-dist-in 4.2294 None None None XRAY 3.35 0.228 0.271 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3FAAE P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.355 13.3659 BLAminus -131.48, -168.05 37.37, 86.28 -107.7, 26.02 296.92, 176.17 -65.92, -19.56 in-in in 7.7814 Saltbr-in 3.0945 HRD-in -66.77, -57.93 79.95, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.13, 169.87 APE9-dihe-na 90.72, 172.5 APE8-dihe-in -64.72, 129.04 APE8-rot-in 310.98 APE67-dihe-in -56.46, -40.64 -59.57, -42.14 APE12-dist-in 11.9901 APE11-dist-in 12.0559 APE10-dist-in 6.5703 APE9-dist-in 3.9816 None None None XRAY 3.35 0.228 0.271 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 8YHFA P36897 201 498 503.0 A1D6I:601 Type1 Active DFGin 6.0367 13.1516 BLAminus -127.63, -168.18 39.33, 73.78 -89.91, 13.29 302.44, 7.93 -62.86, -27.56 in-in in 7.7993 Saltbr-in 3.0294 HRD-in -79.9, -54.99 79.42, -3.09 in-in-in SNCiii in-in ActLoopNT-in 2.9537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.79, -23.11 APE9-dihe-na -96.35, -152.57 APE8-dihe-in -84.18, 124.71 APE8-rot-in 302.64 APE67-dihe-in -56.72, -32.39 -61.45, -41.11 APE12-dist-in 13.1782 APE11-dist-in 12.22 APE10-dist-in 6.2179 APE9-dist-in 3.8345 None None None XRAY 1.4 0.167 0.192 A 343.0 298.0 0 32 32 0 [[205, 494]] 1.0 8yhf Homo sapiens TKL_TGFBR1_HUMAN TKL 5e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 4X2JA P36897 200 501 503.0 3WN:60601 Type1.5_Back Active DFGin 6.2455 13.0815 BLAminus -129.47, -176.48 54.06, 62.42 -89.1, 7.12 300.54, 6.95 -58.75, -23.34 in-in in 7.5948 Saltbr-in 2.782 HRD-in -70.93, -49.34 73.15, -2.13 in-in-in SNCiii in-in ActLoopNT-in 2.9177 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.13, 172.46 APE9-dihe-na 95.45, -178.89 APE8-dihe-in -79.7, 121.22 APE8-rot-in 304.99 APE67-dihe-in -57.38, -35.27 -55.84, -42.14 APE12-dist-in 11.7897 APE11-dist-in 11.8977 APE10-dist-in 6.1985 APE9-dist-in 3.7642 None None None XRAY 1.69 0.167 0.184 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2j Homo sapiens TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 4X2KA P36897 200 501 503.0 3WO:60601 Type1.5_Back Active DFGin 6.2455 13.0815 BLAminus -129.47, -176.48 54.06, 62.42 -89.1, 7.12 300.54, 6.95 -58.75, -23.34 in-in in 7.5948 Saltbr-in 2.782 HRD-in -70.93, -49.34 73.15, -2.13 in-in-in SNCiii in-in ActLoopNT-in 2.9177 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.13, 172.46 APE9-dihe-na 95.45, -178.89 APE8-dihe-in -79.7, 121.22 APE8-rot-in 304.99 APE67-dihe-in -57.38, -35.27 -55.84, -42.14 APE12-dist-in 11.7897 APE11-dist-in 11.8977 APE10-dist-in 6.1985 APE9-dist-in 3.7642 None None None XRAY 1.69 0.167 0.184 A 305.0 302.0 0 32 32 0 [[205, 494]] 1.0 4x2k Homo sapiens TKL_TGFBR1_HUMAN TKL 3.2e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 5QIMA P36897 200 501 503.0 J2Y:60601 Type1.5_Back Active DFGin 6.3236 13.3216 BLAminus -128.33, -166.59 51.25, 57.82 -86.79, 6.35 301.95, 6.09 -60.92, -25.47 in-in in 7.8472 Saltbr-in 2.81 HRD-in -73.31, -54.57 78.67, -3.84 in-in-in SNCiii in-in ActLoopNT-in 2.9307 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.1, -24.0 APE9-dihe-na -84.65, -159.21 APE8-dihe-in -83.03, 124.26 APE8-rot-in 298.64 APE67-dihe-in -57.08, -33.68 -53.72, -43.01 APE12-dist-in 13.141 APE11-dist-in 12.3244 APE10-dist-in 6.2586 APE9-dist-in 3.636 None None None XRAY 1.75 0.169 0.188 A 306.0 302.0 0 32 32 0 [[205, 494]] 1.0 5qim Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 6B8YA P36897 200 502 503.0 D0A:60601 Type1.5_Back Active DFGin 6.0545 13.0759 BLAminus -131.41, -174.19 61.19, 66.23 -95.1, 10.56 300.15, 7.66 -60.38, -25.6 in-in in 7.7706 Saltbr-in 2.9079 HRD-in -74.58, -53.37 74.48, -1.06 in-in-in SNCiii in-in ActLoopNT-in 2.9591 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -84.69, -30.19 APE9-dihe-na -79.71, -163.36 APE8-dihe-in -78.33, 124.12 APE8-rot-in 302.16 APE67-dihe-in -55.15, -33.95 -56.38, -43.01 APE12-dist-in 12.8956 APE11-dist-in 12.272 APE10-dist-in 6.1925 APE9-dist-in 3.665 T204D None None XRAY 1.65 0.18 0.208 A 307.0 303.0 0 32 32 0 [[205, 494]] 1.0 6b8y Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 2X7OC P36897 171 500 503.0 ZOP:600 Type1.5_Back Active DFGin 6.8533 13.7407 BLAminus -128.05, 170.08 59.35, 88.53 -108.53, 28.35 289.5, 149.12 -69.05, -31.39 in-in in 8.0731 Saltbr-in 3.511 HRD-in -65.39, -40.6 69.36, -25.98 in-in-in SNCiii in-in ActLoopNT-in 3.0597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.94, 148.96 APE9-dihe-na 97.31, -171.76 APE8-dihe-in -74.42, 131.23 APE8-rot-in 314.85 APE67-dihe-in -65.62, -33.63 -61.56, -33.26 APE12-dist-in 11.7848 APE11-dist-in 11.7925 APE10-dist-in 5.9672 APE9-dist-in 4.7319 None None None XRAY 3.7 0.267 0.273 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 2X7OD P36897 171 500 503.0 ZOP:600 Type1.5_Back Active DFGin 6.8515 13.7705 BLAminus -128.04, 169.94 59.4, 88.47 -108.43, 28.21 289.11, 149.16 -69.32, -30.88 in-in in 8.0909 Saltbr-in 3.5347 HRD-in -65.64, -40.65 69.2, -26.08 in-in-in SNCiii in-in ActLoopNT-in 3.0568 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.87, 149.08 APE9-dihe-na 96.88, -171.59 APE8-dihe-in -74.3, 131.16 APE8-rot-in 314.89 APE67-dihe-in -64.63, -35.86 -61.66, -32.82 APE12-dist-in 11.7959 APE11-dist-in 11.8009 APE10-dist-in 5.9723 APE9-dist-in 4.735 None None None XRAY 3.7 0.267 0.273 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 2X7OE P36897 171 500 503.0 ZOP:600 Type1.5_Back Active DFGin 6.8561 13.7287 BLAminus -128.08, 169.89 59.79, 88.24 -108.3, 28.24 289.35, 149.2 -69.25, -30.86 in-in in 8.09 Saltbr-in 3.5516 HRD-in -65.48, -40.48 69.3, -25.97 in-in-in SNCiii in-in ActLoopNT-in 3.0589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.31, 151.21 APE9-dihe-na 97.11, -171.6 APE8-dihe-in -74.4, 131.12 APE8-rot-in 315.09 APE67-dihe-in -65.13, -34.5 -61.63, -32.52 APE12-dist-in 11.7792 APE11-dist-in 11.735 APE10-dist-in 5.956 APE9-dist-in 4.7312 None None None XRAY 3.7 0.267 0.273 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3KCFA P36897 171 500 503.0 JZO:1 Type1.5_Back Active DFGin 6.1932 12.9048 BLAminus -150.7, 165.18 67.92, 79.43 -90.06, 14.08 309.25, 11.69 -44.14, -39.87 in-in in 8.1956 Saltbr-in 2.8368 HRD-in -56.75, -49.06 70.7, 0.3 in-in-in SNCiii in-in ActLoopNT-in 2.9397 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -96.99, 164.53 APE9-dihe-na 104.66, 167.11 APE8-dihe-in -69.97, 124.0 APE8-rot-in 297.54 APE67-dihe-in -37.23, -57.4 -40.07, -69.34 APE12-dist-in 11.4628 APE11-dist-in 12.1707 APE10-dist-in 6.1624 APE9-dist-in 3.7623 None None None XRAY 2.8 0.237 0.278 A 342.0 328.0 2 32 30 2 [[205, 494]] 1.0 3kcf Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3KCFB P36897 171 501 503.0 JZO:2 Type1.5_Back Active DFGin 6.0248 12.6274 BLAminus -135.28, -176.57 58.41, 88.07 -103.95, 28.48 315.03, 7.91 -62.87, -35.81 in-in in 8.1446 Saltbr-in 2.6009 HRD-in -81.18, -54.27 77.68, -8.36 in-in-in SNCiii in-in ActLoopNT-in 2.9703 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.7, -176.11 APE9-dihe-na 95.21, 172.61 APE8-dihe-in -76.23, 133.32 APE8-rot-in 308.48 APE67-dihe-in -45.62, -25.89 -46.72, -68.47 APE12-dist-in 11.5191 APE11-dist-in 11.4129 APE10-dist-in 5.9541 APE9-dist-in 3.7322 None None None XRAY 2.8 0.237 0.278 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 3kcf Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3KCFC P36897 171 500 503.0 JZO:3 Type1.5_Back Active DFGin 6.6922 12.959 BLAminus -135.28, 165.04 69.33, 88.35 -106.61, 31.51 302.0, 1.76 -58.82, -55.68 in-in in 8.0361 Saltbr-in 2.3791 HRD-in -81.96, -30.19 61.27, -12.68 in-in-in SNCiii in-in ActLoopNT-in 2.8972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.43, -160.74 APE9-dihe-na 83.32, -178.05 APE8-dihe-in -94.01, 131.52 APE8-rot-in 317.12 APE67-dihe-in -41.44, -18.99 -53.51, -67.7 APE12-dist-in 10.7421 APE11-dist-in 11.8422 APE10-dist-in 6.2245 APE9-dist-in 3.8557 None None None XRAY 2.8 0.237 0.278 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3kcf Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3KCFD P36897 171 500 503.0 JZO:4 Type1.5_Back Active DFGin 6.8886 12.9989 BLAminus -135.85, -173.78 57.12, 75.33 -93.52, 22.15 298.91, 178.96 -63.23, -14.31 in-in in 8.2643 Saltbr-in 2.8937 HRD-in -62.47, -52.01 74.47, -2.58 in-in-in SNCiii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.66, 172.34 APE9-dihe-na 99.39, 173.59 APE8-dihe-in -80.33, 105.05 APE8-rot-in 316.25 APE67-dihe-in -46.61, -41.72 -34.28, -49.6 APE12-dist-in 12.0425 APE11-dist-in 12.0502 APE10-dist-in 6.3267 APE9-dist-in 4.0441 None None None XRAY 2.8 0.237 0.278 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3kcf Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3KCFE P36897 171 500 503.0 JZO:5 Type1.5_Back Active DFGin 6.468 12.9815 BLAminus -143.17, -179.95 57.87, 88.27 -108.02, 21.93 307.67, 3.89 -69.37, -7.25 in-in in 8.0283 Saltbr-in 2.8557 HRD-in -68.17, -50.18 73.66, 3.11 in-in-in SNCiii in-in ActLoopNT-in 2.9023 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.74, 177.4 APE9-dihe-na 104.24, -175.74 APE8-dihe-in -89.11, 123.84 APE8-rot-in 292.33 APE67-dihe-in -50.81, -36.21 -50.11, -48.46 APE12-dist-in 9.931 APE11-dist-in 12.0011 APE10-dist-in 6.2167 APE9-dist-in 3.7965 None None None XRAY 2.8 0.237 0.278 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3kcf Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1B6CB P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.8508 13.3938 BLAminus -130.85, -177.18 52.69, 80.31 -95.42, 25.6 300.29, 176.12 -64.72, -15.76 in-out in 8.6028 Saltbr-out 4.1145 HRD-in -69.56, -62.44 85.43, -5.19 out-in-out SNCoio in-out ActLoopNT-in 2.9563 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.23, 170.19 APE9-dihe-na -45.35, 160.71 APE8-dihe-in -68.99, 127.88 APE8-rot-in 301.39 APE67-dihe-in -71.24, -15.17 -60.4, -35.84 APE12-dist-in 11.4529 APE11-dist-out 7.3149 APE10-dist-out 8.4482 APE9-dist-in 3.7304 None None None XRAY 2.6 0.249 0.269 B 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1B6CD P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.9628 13.3173 BLAminus -130.99, -177.26 52.75, 80.27 -95.41, 25.6 300.53, 176.04 -64.6, -15.85 in-out in 8.6001 Saltbr-out 4.1147 HRD-in -69.77, -62.44 85.53, -5.06 out-in-out SNCoio in-out ActLoopNT-in 2.9575 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.35, 170.01 APE9-dihe-na -45.12, 160.61 APE8-dihe-in -69.1, 128.03 APE8-rot-in 301.09 APE67-dihe-in -71.13, -15.35 -60.35, -36.04 APE12-dist-in 11.4533 APE11-dist-out 7.3138 APE10-dist-out 8.445 APE9-dist-in 3.7254 None None None XRAY 2.6 0.249 0.269 D 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1B6CF P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.9976 13.8141 BLAminus -130.93, -177.22 52.78, 80.13 -95.35, 25.63 300.41, 176.19 -64.73, -15.73 in-out in 8.6018 Saltbr-out 4.1142 HRD-in -69.45, -62.52 85.59, -5.04 out-in-out SNCoio in-out ActLoopNT-in 2.9568 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.38, 170.18 APE9-dihe-na -45.27, 160.69 APE8-dihe-in -69.12, 128.05 APE8-rot-in 301.08 APE67-dihe-in -71.24, -15.27 -60.51, -35.82 APE12-dist-in 11.4545 APE11-dist-out 7.3138 APE10-dist-out 8.4448 APE9-dist-in 3.7272 None None None XRAY 2.6 0.249 0.269 F 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1B6CH P36897 175 500 503.0 No_ligand No_ligand Inactive DFGin 6.933 13.3732 BLAminus -131.03, -177.2 52.83, 80.24 -95.22, 25.39 300.35, 176.04 -64.71, -15.81 in-out in 8.6014 Saltbr-out 4.1131 HRD-in -69.67, -62.6 85.56, -5.13 out-in-out SNCoio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -139.24, 170.15 APE9-dihe-na -45.32, 160.68 APE8-dihe-in -69.01, 127.87 APE8-rot-in 301.38 APE67-dihe-in -71.25, -15.25 -60.38, -35.9 APE12-dist-in 11.451 APE11-dist-out 7.3115 APE10-dist-out 8.4461 APE9-dist-in 3.7295 None None None XRAY 2.6 0.249 0.269 H 342.0 326.0 0 32 32 0 [[205, 494]] 1.0 1b6c Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1RW8A P36897 200 500 503.0 580:501 Type1 Inactive DFGin 6.0226 12.8451 BLAminus -123.87, -176.48 52.01, 78.57 -101.69, 16.55 307.13, 6.03 -62.1, -24.92 in-in in 7.8414 Saltbr-in 3.4673 HRD-in -69.23, -61.02 80.12, 4.14 in-in-out SNCiio in-out ActLoopNT-in 2.9024 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -83.25, -151.65 APE9-dihe-na -88.81, -163.17 APE8-dihe-in -80.66, 118.18 APE8-rot-in 309.35 APE67-dihe-in -55.07, -38.39 -52.69, -43.2 APE12-dist-in 11.4864 APE11-dist-in 8.8535 APE10-dist-out 8.6198 APE9-dist-in 4.1068 None None None XRAY 2.4 0.26 0.291 A 301.0 301.0 0 32 32 0 [[205, 494]] 1.0 1rw8 Homo sapiens TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1PY5A P36897 200 500 503.0 PY1:700 Type1 Inactive DFGin 6.3254 13.0957 BLAminus -139.22, -176.23 51.49, 62.68 -91.32, 17.81 306.9, 168.43 -57.65, -31.73 in-in in 7.8314 Saltbr-in 2.8966 HRD-in -74.07, -48.58 75.5, -7.56 in-in-out SNCiio in-out ActLoopNT-in 2.8618 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.55, -147.04 APE9-dihe-na -97.21, -166.02 APE8-dihe-in -77.65, 124.21 APE8-rot-in 307.07 APE67-dihe-in -64.31, -27.94 -63.63, -30.26 APE12-dist-in 11.444 APE11-dist-in 8.66 APE10-dist-out 8.5722 APE9-dist-in 4.1185 None None None XRAY 2.3 0.26 0.292 A 326.0 301.0 0 32 32 0 [[205, 494]] 1.0 1py5 Homo sapiens TKL_TGFBR1_HUMAN TKL 4.1e-85 291.4 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 2X7OB P36897 171 500 503.0 ZOP:600 Type1 Inactive DFGin 6.8577 13.7456 BLAminus -128.22, 169.83 59.7, 88.26 -108.23, 28.26 289.27, 149.16 -69.33, -30.83 in-out in 8.1184 Saltbr-out 3.8328 HRD-in -65.55, -40.47 69.31, -25.99 out-in-in SNCoii in-in ActLoopNT-in 3.059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.06, 149.04 APE9-dihe-na 97.27, -171.94 APE8-dihe-in -74.39, 131.11 APE8-rot-in 314.97 APE67-dihe-in -65.1, -35.09 -61.66, -32.49 APE12-dist-in 11.7932 APE11-dist-in 11.7932 APE10-dist-in 5.9674 APE9-dist-in 4.7272 None None None XRAY 3.7 0.267 0.273 B 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 2x7o Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3FAAC P36897 171 500 503.0 55F:601 Type1 Inactive DFGin 6.142 13.1414 BLAminus -126.27, 176.42 50.71, 78.49 -102.58, 30.06 320.3, 19.34 -66.31, -17.95 in-in in 7.9903 Saltbr-in 2.6623 HRD-in -67.56, -21.99 46.1, 19.37 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -120.66, 131.05 APE9-dihe-na 148.7, 175.0 APE8-dihe-in -102.93, 87.73 APE8-rot-in 305.5 APE67-dihe-out -28.83, -55.82 5.18, -84.04 APE12-dist-in 11.4809 APE11-dist-in 12.1489 APE10-dist-in 6.2467 APE9-dist-in 4.208 None None None XRAY 3.35 0.228 0.271 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 1VJYA P36897 201 503 503.0 460:999 Type1 None DFGin 6.0948 12.7955 BLAminus -131.96, -168.3 46.73, 72.17 -95.27, 7.02 307.89, 4.49 -49.86, -32.3 in-in in 7.7255 Saltbr-in 2.7526 HRD-in -71.95, -49.94 73.94, 4.16 in-in-none SNCiin in-none ActLoopNT-in 2.8478 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -108.72, 178.34 APE9-dihe-na 100.08, -177.16 APE8-dihe-in -88.48, 114.15 APE8-rot-in 304.07 APE67-dihe-in -56.76, -36.75 -44.55, -45.61 APE12-dist-none 999.0 APE11-dist-in 11.5573 APE10-dist-in 6.5127 APE9-dist-in 3.8649 None None None XRAY 2.0 0.223 0.275 A 303.0 299.0 4 32 28 4 [[205, 494]] 1.0 1vjy Homo sapiens TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3GXLA P36897 201 498 503.0 QIG:60999 Type1 None DFGin 5.986 13.1617 BLAminus -117.01, -170.6 33.6, 86.88 -102.63, 15.85 311.96, 176.51 -62.1, -23.52 in-in in 8.2229 Saltbr-in 2.9297 HRD-in -71.35, -53.37 77.01, 1.76 in-in-none SNCiin in-none ActLoopNT-in 2.9585 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -62.74, 167.86 APE9-dihe-na 117.67, 172.21 APE8-dihe-in -83.62, 118.05 APE8-rot-in 304.44 APE67-dihe-in -50.23, -35.35 -45.35, -55.49 APE12-dist-none 999.0 APE11-dist-in 12.1584 APE10-dist-in 6.7392 APE9-dist-in 4.1731 None None None XRAY 1.8 0.228 0.263 A 303.0 285.0 13 32 27 5 [[205, 494]] 1.0 3gxl Homo sapiens TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3HMMA P36897 201 498 503.0 855:60857 Type1 None DFGin 6.1186 13.0492 BLAminus -127.07, -168.91 53.99, 65.82 -94.96, 13.15 305.68, 3.69 -60.53, -23.27 in-in in 8.024 Saltbr-in 2.8121 HRD-in -74.05, -51.32 76.01, -1.97 in-in-none SNCiin in-none ActLoopNT-in 2.9341 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -160.63 APE8-dihe-in -79.78, 120.6 APE8-rot-in 300.84 APE67-dihe-in -55.11, -37.41 -48.22, -47.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.917 None None None XRAY 1.7 0.223 0.241 A 303.0 293.0 5 32 27 5 [[205, 494]] 1.0 3hmm Homo sapiens TKL_TGFBR1_HUMAN TKL 3.1e-85 291.8 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 9J9DA P36897 202 502 503.0 A1L30:701 Type1 None DFGin 5.9671 12.4549 BLAminus -128.65, -173.5 51.95, 67.83 -91.44, 10.62 307.73, 2.77 -64.11, -26.42 in-in in 8.0195 Saltbr-in 2.8069 HRD-in -76.64, -51.57 79.18, -0.61 in-in-none SNCiin in-none ActLoopNT-in 2.9198 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -92.35, -34.47 APE9-dihe-na -89.02, -159.15 APE8-dihe-in -77.18, 122.97 APE8-rot-in 307.18 APE67-dihe-in -57.12, -34.57 -60.97, -41.48 APE12-dist-none 999.0 APE11-dist-in 12.1448 APE10-dist-in 6.1626 APE9-dist-in 4.0669 None None None XRAY 1.337 0.191 0.209 A 306.0 296.0 5 32 30 2 [[205, 494]] 1.0 9j9d Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TGFBR1 TGFR1_HUMAN 3TZMA P36897 200 496 503.0 085:1 Type1 None DFGin 6.0654 13.1056 BLAminus -122.58, -169.81 59.22, 59.29 -91.38, 11.48 304.6, 5.41 -64.05, -23.93 in-in in 7.9635 Saltbr-in 2.8335 HRD-in -81.31, -50.79 80.1, -5.96 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -87.36, 160.54 APE9-dihe-na 102.22, -177.2 APE8-dihe-in -87.37, 126.2 APE8-rot-in 298.62 APE67-dihe-in -59.36, -31.96 -58.47, -41.28 APE12-dist-none 999.0 APE11-dist-in 12.2382 APE10-dist-in 6.1835 APE9-dist-in 3.825 None None None XRAY 1.7 0.172 0.205 A 309.0 295.0 2 32 30 2 [[205, 494]] 1.0 3tzm Homo sapiens TKL_TGFBR1_HUMAN TKL 3.4e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1

TKL_TGFBR1 (TGF-beta receptor type-1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name